304462-19-9 | Ave 0991

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$66.00	$46.00
5mg	98%	in stock	$278.00	$195.00
10mg	98%	in stock	$489.00	$342.00

Description

• Catalog Number: AF32536
• Chemical Name: Ave 0991
• CAS Number: 304462-19-9
• Molecular Formula: C29H32N4O5S2
• Molecular Weight: 580.7182
• MDL Number: MFCD27992063
• SMILES: CCNC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(nc(c1C=O)OC)c1ccccc1)CC(C)C

Computed Properties

• Complexity: 931
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 40
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 11
• XLogP3: 5.6

Literature

• Anti-atherosclerotic effect of the angiotensin 1-7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis.

  British journal of pharmacology 20171101

• Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor.

  Blood 20150122

• Possible mechanism of the cardio-renal protective effects of AVE-0991, a non-peptide Mas-receptor agonist, in diabetic rats.

  Journal of the renin-angiotensin-aldosterone system : JRAAS 20120901

• Angiotensin-(1-7) receptor Mas agonist ameliorates progress of atherosclerosis in apoE-knockout mice.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20120201

• The effect of AVE 0991, nebivolol and doxycycline on inflammatory mediators in an apoE-knockout mouse model of atherosclerosis.

  Medical science monitor : international medical journal of experimental and clinical research 20120101

• The angiotensin-(1-7) receptor agonist AVE0991 is cardioprotective in diabetic rats.

  European journal of pharmacology 20080820

• Evidence for Mas-mediated bradykinin potentiation by the angiotensin-(1-7) nonpeptide mimic AVE 0991 in normotensive rats.

  Hypertension (Dallas, Tex. : 1979) 20071001

• Isoproterenol-induced impairment of heart function and remodeling are attenuated by the nonpeptide angiotensin-(1-7) analogue AVE 0991.

  Life sciences 20070823

• Short-term angiotensin(1-7) receptor MAS stimulation improves endothelial function in normotensive rats.

  Hypertension (Dallas, Tex. : 1979) 20051001

• The endothelium-dependent vasodilator effect of the nonpeptide Ang(1-7) mimic AVE 0991 is abolished in the aorta of mas-knockout mice.

  Journal of cardiovascular pharmacology 20050901

• Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney.

  Hypertension (Dallas, Tex. : 1979) 20041001

• 14C-labeled and large-scale synthesis of the angiotensin-(1-7)-receptor agonist AVE 0991 by cross-coupling reactions.

  The Journal of organic chemistry 20030627