30827-99-7 | 4-(2-Aminoethyl)benzenesulfonyl fluoride, HCl

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$15.00	$10.00
100mg	95%	in stock	$59.00	$41.00
250mg	95%	in stock	$102.00	$71.00
1g	95%	in stock	$113.00	$79.00
5g	95%	in stock	$401.00	$281.00
10g	95%	in stock	$634.00	$444.00
25g	95%	in stock	$1,255.00	$879.00

Description

• Catalog Number: AB41617
• Chemical Name: 4-(2-Aminoethyl)benzenesulfonyl fluoride, HCl
• CAS Number: 30827-99-7
• Molecular Formula: C8H11ClFNO2S
• Molecular Weight: 239.6948
• MDL Number: MFCD00132962
• SMILES: NCCc1ccc(cc1)S(=O)(=O)F.Cl
• NSC Number: 727364

Computed Properties

• Complexity: 239
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3

Literature

• Amyloid β induces NLRP3 inflammasome activation in retinal pigment epithelial cells via NADPH oxidase- and mitochondria-dependent ROS production.

  Journal of biochemical and molecular toxicology 20170601

• Crystal structures of BapA complexes with β-lactam-derived inhibitors illustrate substrate specificity and enantioselectivity of β-aminopeptidases.

  Chembiochem : a European journal of chemical biology 20120924

• Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase.

  Journal of medicinal chemistry 20120913

• Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction.

  Free radical biology & medicine 20120901

• Androgen deprivation causes truncation of the C-terminal region of androgen receptor in human prostate cancer LNCaP cells.

  Cancer science 20120601

• Doxycycline indirectly inhibits proteolytic activation of tryptic kallikrein-related peptidases and activation of cathelicidin.

  The Journal of investigative dermatology 20120501

• Pitfalls in the determination of human acylated ghrelin plasma concentrations using a double antibody enzyme immunometric assay.

  Clinical biochemistry 20120101

• A model to evaluate toxic factors influencing islets during collagenase digestion: the role of serine protease inhibitor in the protection of islets.

  Cell transplantation 20120101

• Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease.

  PloS one 20120101

• Serine protease inhibitor, 4-(2-aminoethyl)-benzene sulfonyl fluoride, impairs IL-12-induced activation of pSTAT4β, NFκB, and select pro-inflammatory mediators from estrogen-treated mice.

  Immunobiology 20111201

• Serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) inhibits the rat embryo implantation in vivo and interferes with cell adhesion in vitro.

  Contraception 20111201

• Development of a fluorescence resonance energy transfer peptide library technology for detection of protease contaminants in protein-based raw materials used in diagnostic assays.

  Assay and drug development technologies 20111001

• Fluoride does not inhibit enamel protease activity.

  Journal of dental research 20110401

• A practical guide for the stabilization of acylghrelin in human blood collections.

  Clinical endocrinology 20110301

• Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization.

  The Journal of biological chemistry 20110121

• A trypsin-like serine protease is involved in pseudorabies virus invasion through the basement membrane barrier of porcine nasal respiratory mucosa.

  Veterinary research 20110101

• Peptidases of pinworms Syphacia muris and Passalurus ambiguus.

  Experimental parasitology 20101001

• Comparative pharmacology of chemically distinct NADPH oxidase inhibitors.

  British journal of pharmacology 20101001

• Serine proteases in histone deacetylase inhibitor-induced apoptosis.

  Molecular cancer therapeutics 20100801

• Multiple protective functions of catalase against intercellular apoptosis-inducing ROS signaling of human tumor cells.

  Biological chemistry 20100601

• Ontogeny of acylated ghrelin degradation in the rat.

  Peptides 20100201

• Carboxymethyl-starch excipients for gastrointestinal stable oral protein formulations containing protease inhibitors.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20100101

• Serine protease inhibitors suppress pancreatic endogenous proteases and modulate bacterial neutral proteases.

  Islets 20100101

• HIV-1 integrase-hydrolyzing antibodies from sera of HIV-infected patients.

  Biochimie 20090901

• Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes.

  Molecular and cellular endocrinology 20090813

• Tumour necrosis factor-alpha processing in interstitial lung disease: a potential role for exogenous proteinase-3.

  Clinical and experimental immunology 20090501

• Shedding of gACE from residual body membrane of rat sperm.

  Legal medicine (Tokyo, Japan) 20090401

• The effect of bafilomycin A1 and protease inhibitors on the degradation and recycling of a Class 5-mutant LDLR.

  Acta biochimica et biophysica Sinica 20090301

• Comparison of trypsin inhibitors in preservation solution for islet isolation.

  Cell transplantation 20090101

• Potential role of proprotein convertase SKI-1 in the mineralization of primary bone.

  Cells, tissues, organs 20081201

• Modification of amyloid-beta(1-40) by a protease inhibitor creates risk of error in mass spectrometric quantitation of amyloid-beta(1-42).

  Analytical biochemistry 20081115

• Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis and sensitizes prostate cancer cells to TRAIL-mediated apoptosis.

  Cell death and differentiation 20081101

• A method for quantifying melanosome transfer efficacy from melanocytes to keratinocytes in vitro.

  Pigment cell & melanoma research 20081001

• Treatment of cells with n-alpha-tosyl-L-phenylalanine-chloromethyl ketone induces the proteolytic loss of STAT6 transcription factor.

  Molecular immunology 20080901

• Novel phospholipolytic activities associated with electronegative low-density lipoprotein are involved in increased self-aggregation.

  Biochemistry 20080805

• Human laminin-332 degradation by Candida proteinases.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20080701

• GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis.

  Journal of cellular physiology 20080601

• Sulphur and nitrogen regulation of the protease-encoding ACP1 gene in the fungus Botrytis cinerea: correlation with a phospholipase D activity.

  Microbiology (Reading, England) 20080501

• Protease activity of allergenic pollen of cedar, cypress, juniper, birch and ragweed.

  Allergology international : official journal of the Japanese Society of Allergology 20080301

• Endogenous pancreatic protease activity and methods for impeding their function.

  Transplantation proceedings 20080301

• Relationship between carbachol hyperstimulation-induced pancreatic intracellular trypsinogen and NF-kappa B activation in rats in vitro.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20080201

• Proinflammatory impact of Staphylococcus epidermidis on the nasal epithelium quantified by IL-8 and GRO-alpha responses in primary human nasal epithelial cells.

  International archives of allergy and immunology 20080101

• Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells.

  Neurotoxicology 20071101

• Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis.

  Journal of lipid research 20071101

• The role of fungal proteinases in pathophysiology of Stachybotrys chartarum.

  Mycopathologia 20071001

• Association of specific proteolytic processing of bone sialoprotein and bone acidic glycoprotein-75 with mineralization within biomineralization foci.

  The Journal of biological chemistry 20070907

• A single intrauterine injection of the serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride reversibly inhibits embryo implantation in mice.

  Contraception 20070901

• A novel 51-kDa fragment of the large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase formed in the stroma of chloroplasts in dark-induced senescing wheat leaves.

  Physiologia plantarum 20070901

• PAR-2 activation regulates IL-8 and GRO-alpha synthesis by NF-kappaB, but not RANTES, IL-6, eotaxin or TARC expression in nasal epithelium.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20070701

• Potential effects of PKC or protease inhibitors on acute pancreatitis-induced tissue injury in rats.

  Vascular pharmacology 20070601

• Endoplasmic reticulum stress-induced cell death mediated by the proteasome.

  Cell death and differentiation 20070601

• A Bax/Bak-independent mechanism of cytochrome c release.

  The Journal of biological chemistry 20070601

• Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease.

  Cell research 20070201

• Adjustment of digestion enzyme composition improves islet isolation outcome from marginal grade human donor pancreata.

  Cell and tissue banking 20070101

• Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2.

  The international journal of biochemistry & cell biology 20070101

• Characterization of the de novo biosynthetic enzyme of platelet activating factor, DDT-insensitive cholinephosphotransferase, of human mesangial cells.

  Mediators of inflammation 20070101

• Cleavage of misfolded nuclear receptor corepressor confers resistance to unfolded protein response-induced apoptosis.

  Cancer research 20061015

• Nitric oxide-induced down-regulation of beta-catenin in colon cancer cells by a proteasome-independent specific pathway.

  Gastroenterology 20061001

• Induction of CXC chemokines in A549 airway epithelial cells by trypsin and staphylococcal proteases - a possible route for neutrophilic inflammation in chronic rhinosinusitis.

  Clinical and experimental immunology 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• The influence of fibrin polymerization and platelet-mediated contractile forces on citrated whole blood thromboelastography profile.

  Thrombosis and haemostasis 20060501

• Platelet-activating factor-acetylhydrolase can monodeacylate and inactivate lipoteichoic acid.

  Clinical and vaccine immunology : CVI 20060401

• Cleavage of epidermal growth factor receptor by caspase during apoptosis is independent of its internalization.

  Oncogene 20060309

• Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.

  Journal of molecular biology 20060127

• Coronary microvascular endothelial cell growth regulates expression of the gene encoding p22-phox.

  Free radical biology & medicine 20051115

• Shedding of the germinal angiotensin I-converting enzyme (gACE) involves a serine protease and is activated by epididymal fluid.

  Biology of reproduction 20051101

• Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition.

  Clinical and experimental immunology 20051101

• Cleavage of p21/WAF1/CIP1 by proteinase 3 modulates differentiation of a monocytic cell line. Molecular analysis of the cleavage site.

  The Journal of biological chemistry 20050826

• Reactive oxygen species-linked regulation of the multidrug resistance transporter P-glycoprotein in Nox-1 overexpressing prostate tumor spheroids.

  FEBS letters 20050815

• Coupling of size-exclusion chromatography to a continuous assay for subtilisin using a fluorescence resonance energy transfer peptide substrate: testing of two standard inhibitors.

  Journal of chromatography. A 20050722

• Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes.

  The Journal of biological chemistry 20050610

• The interaction of human tryptase-beta with small molecule inhibitors provides new insights into the unusual functional instability and quaternary structure of the protease.

  Biochemistry 20050308

• Antioxidants inhibit human endothelial cell functions through down-regulation of endothelial nitric oxide synthase activity.

  European journal of pharmacology 20050307

• c-Src and hydrogen peroxide mediate transforming growth factor-beta1-induced smooth muscle cell-gene expression in 10T1/2 cells.

  Arteriosclerosis, thrombosis, and vascular biology 20050201

• Pro- and anti-apoptotic effects of an inhibitor of chymotrypsin-like serine proteases.

  Cell cycle (Georgetown, Tex.) 20041201

• Proteasome proteolytic activity in hematopoietic cells from patients with chronic myeloid leukemia and multiple myeloma.

  Haematologica 20041201

• The N-terminal extension of plant mitochondrial carrier proteins is removed by two-step processing: the first cleavage is by the mitochondrial processing peptidase.

  Journal of molecular biology 20041119

• NADPH oxidase-dependent acid production in airway epithelial cells.

  The Journal of biological chemistry 20040827

• Aminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac-VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme-1.

  FEBS letters 20040827

• Antioxidants inhibit angiogenesis in vivo through down-regulation of nitric oxide synthase expression and activity.

  Free radical research 20040501

• Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor.

  Biological chemistry 20031201

• Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions.

  Cell death and differentiation 20031001

• A serine protease is involved in the initiation of DNA damage-induced apoptosis.

  Cell death and differentiation 20031001

• A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.

  The Journal of biological chemistry 20030815

• Reelin promotes peripheral synapse elimination and maturation.

  Science (New York, N.Y.) 20030801

• Identification and partial characterization of two inducible gelatin-cleavage activities localized to the sea urchin extraembryonic matrix, the hyaline layer.

  Biochimica et biophysica acta 20030407

• Characterization of a serine protease activity in Sarcocystis neurona merozoites.

  The Journal of parasitology 20030401

• Evaluation of Pefabloc as a serine protease inhibitor during human-islet isolation.

  Transplantation 20030227

• CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals.

  Genes & development 20030201

• Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor.

  Molecular pharmacology 20030101

• Improved islet yields from Macaca nemestrina and marginal human pancreata after two-layer method preservation and endogenous trypsin inhibition.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20030101

• Gibberellin-mediated proteasome-dependent degradation of the barley DELLA protein SLN1 repressor.

  The Plant cell 20021201

• Effect of pefabloc on islet isolation from cold preserved rat pancreas.

  Transplantation proceedings 20021101

• Platelet phagocytosis and processing of beta-amyloid precursor protein as a mechanism of macrophage activation in atherosclerosis.

  Circulation research 20020614

• Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis.

  The Journal of antimicrobial chemotherapy 20020501

• Oxidative stress increased respiration and generation of reactive oxygen species, resulting in ATP depletion, opening of mitochondrial permeability transition, and programmed cell death.

  Plant physiology 20020401

• Phospholipase D contributes to transmural pressure control of prorenin processing in juxtaglomerular cell.

  Hypertension (Dallas, Tex. : 1979) 20020201

• Inhibition of NADH/NADPH oxidase affects signal transduction by growth factor receptors in normal fibroblasts.

  Archives of biochemistry and biophysics 20020115

• The central role of thromboxane and platelet activating factor receptors in ex vivo regulation of endotoxin-induced monocyte tissue factor activity in human whole blood.

  Journal of endotoxin research 20020101

• Induction of IkappaB-kinase by cholecystokinin is mediated by trypsinogen activation in rat pancreatic lobules.

  Digestion 20020101

• Inhibition of lipoprotein-associated phospholipase A2 diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages.

  FEBS letters 20010921

• Islet isolation: simple modifications can still yield big improvements.

  Transplantation 20010827

• Serine-protease inhibition during islet isolation increases islet yield from human pancreases with prolonged ischemia.

  Transplantation 20010827

• Tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis is dependent on activation of cysteine and serine proteases.

  Cytokine 20010807

• Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib.

  The Journal of biological chemistry 20010615

• Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid.

  Oncogene 20010607

• Serine protease inhibitor causes F-actin redistribution and inhibition of calcium-mediated secretion in pancreatic acini.

  Gastroenterology 20010601

• Protein kinase C activation by PMA rapidly induces apoptosis through caspase-3/CPP32 and serine protease(s) in a gastric cancer cell line.

  International journal of oncology 20010501

• Characterization of a protease responsible for truncated actin increase in neutrophils of patients with Behçet's disease.

  Biological & pharmaceutical bulletin 20010201

• Studies on digestive proteases from midgut glands of a shrimp, Penaeus indicus, and a lobster, Nephrops norvegicus: Part 1. Proteolytic activity.

  Applied biochemistry and biotechnology 20010201

• Inhibitors of trypsin-like serine proteases prevent DNA damage-induced neuronal death by acting upstream of the mitochondrial checkpoint and of p53 induction.

  Neuroscience 20010101

• A role for serine proteases in mediating phorbol ester-induced differentiation of HL-60 cells.

  Experimental cell research 20000410