312-84-5 | D-Serine

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$6.00	$4.00
5g	95%	in stock	$7.00	$5.00
10g	95%	in stock	$9.00	$6.00
25g	95%	in stock	$11.00	$8.00
100g	95%	in stock	$13.00	$9.00
500g	98%	in stock	$42.00	$29.00

Description

• Catalog Number: AI47189
• Chemical Name: D-Serine
• CAS Number: 312-84-5
• Molecular Formula: C3H7NO3
• Molecular Weight: 105.0926
• MDL Number: MFCD00004269
• SMILES: OC[C@H](C(=O)O)N

Computed Properties

• Complexity: 72.6
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 7
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 2
• XLogP3: -3.1

Literature

• Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice.

  Drug metabolism and disposition: the biological fate of chemicals 20121101

• Functional roles of endogenous D-serine in the chronic pain-induced plasticity of NMDAR-mediated synaptic transmission in the central amygdala of mice.

  Neuroscience letters 20120627

• An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors.

  PloS one 20120101

• Development of a high-throughput method for the determination of pharmacological levels of plasma D-serine.

  Analytical biochemistry 20111215

• The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport.

  British journal of pharmacology 20111201

• N-methyl-D-aspartate receptor-mediated modulations of the anti-allodynic effects of 5-HT1B/1D receptor stimulation in a rat model of trigeminal neuropathic pain.

  European journal of pain (London, England) 20110501

• D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO).

  Journal of neuroscience research 20100601

• Total synthesis of the large non-ribosomal peptide polytheonamide B.

  Nature chemistry 20100401

• [Interaction between gabapentin and D-serin in the formalin orofacial test].

  Investigacion clinica 20091201

• Crystallization and preliminary X-ray analysis of a D-Ala:D-Ser ligase associated with VanG-type vancomycin resistance.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20091001

• Drug design, in vitro pharmacology, and structure-activity relationships of 3-acylamino-2-aminopropionic acid derivatives, a novel class of partial agonists at the glycine site on the N-methyl-D-aspartate (NMDA) receptor complex.

  Journal of medicinal chemistry 20090827

• AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis.

  Nature chemical biology 20090301

• EAAT1 and D-serine expression are early features of human retinal development.

  Experimental eye research 20070501

• D1 dopamine receptor hyperphosphorylation in renal proximal tubules in hypertension.

  Kidney international 20060901

• Neurotransmitter transporters and their impact on the development of psychopharmacology.

  British journal of pharmacology 20060101

• Biochemical characterization of biocontrol agents used for control of root pathogens.

  Communications in agricultural and applied biological sciences 20060101

• Preferred stereoselective brain uptake of d-serine--a modulator of glutamatergic neurotransmission.

  Nuclear medicine and biology 20051101

• The vanG glycopeptide resistance operon from Enterococcus faecalis revisited.

  Molecular microbiology 20031101

• Distribution and pharmacology of alanine-serine-cysteine transporter 1 (asc-1) in rodent brain.

  The European journal of neuroscience 20031001

• Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core.

  The EMBO journal 20030616

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Transport of D-serine via the amino acid transporter ATB(0,+) expressed in the colon.

  Biochemical and biophysical research communications 20020222

• Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.

  The Journal of biological chemistry 20010518

• Resistance to D-cycloserine in the tubercle bacilli: mutation rate and transport of alanine in parental cells and drug-resistant mutants.

  Applied microbiology 19710501