315-22-0 | Monocrotaline

Packsize	Purity	Availability	Price	Discounted Price
50mg	≥98%	in stock	$80.00	$56.00
100mg	≥98%	in stock	$148.00	$104.00
250mg	98%	in stock	$183.00	$128.00
500mg	≥98%	in stock	$308.00	$216.00
1g	98%	in stock	$405.00	$283.00

Description

• Catalog Number: AF57471
• Chemical Name: Monocrotaline
• CAS Number: 315-22-0
• Molecular Formula: C16H23NO6
• Molecular Weight: 325.3569
• MDL Number: MFCD00084656
• SMILES: O=C1O[C@@H]2CCN3[C@@H]2C(=CC3)COC(=O)[C@]([C@]([C@H]1C)(C)O)(C)O

Computed Properties

• Complexity: 575
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 5
• Heavy Atom Count: 23
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 2
• XLogP3: -0.7

Literature

• Liquiritigenin and liquiritin alleviated MCT-induced HSOS by activating Nrf2 antioxidative defense system.

  Toxicology and applied pharmacology 20180915

• Integrative analysis of hepatic microRNA and mRNA to identify potential biological pathways associated with monocrotaline-induced liver injury in mice.

  Toxicology and applied pharmacology 20171015

• Serum microRNA-122-3p, microRNA-194-5p and microRNA-5099 are potential toxicological biomarkers for the hepatotoxicity induced by Airpotato yam.

  Toxicology letters 20171005

• Galectin-3 contributes to vascular fibrosis in monocrotaline-induced pulmonary arterial hypertension rat model.

  Journal of biochemical and molecular toxicology 20170501

• Comparative Study of Hepatotoxicity of Pyrrolizidine Alkaloids Retrorsine and Monocrotaline.

  Chemical research in toxicology 20170220

• Comparative gene and protein expression analyses of a panel of cytokines in acute and chronic drug-induced liver injury in rats.

  Toxicology 20141003

• Caveolin-1 is a negative regulator of NADPH oxidase-derived reactive oxygen species.

  Free radical biology & medicine 20140801

• NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling.

  Arteriosclerosis, thrombosis, and vascular biology 20140801

• Metabolomic analysis of arginine metabolism in acute hepatic injury in rats.

  The Journal of toxicological sciences 20140201

• Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action.

  PloS one 20140101

• The flavonoid quercetin reverses pulmonary hypertension in rats.

  PloS one 20140101

• Organic cation transporter 1 mediates the uptake of monocrotaline and plays an important role in its hepatotoxicity.

  Toxicology 20130915

• Tissue factor antisense deoxyoligonucleotide prevents monocrotaline/LPS hepatotoxicity in mice.

  Journal of applied toxicology : JAT 20130801

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• Sorafenib attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats through suppression of JNK and MMP-9.

  Journal of hepatology 20121101

• Bortezomib alleviates experimental pulmonary arterial hypertension.

  American journal of respiratory cell and molecular biology 20121101

• Superiority of desflurane over sevoflurane and isoflurane in the presence of pressure-overload right ventricle hypertrophy in rats.

  Anesthesiology 20121101

• Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension.

  American journal of respiratory and critical care medicine 20121101

• Beneficial effects of γ-aminobutyric acid on right ventricular pressure and pulmonary vascular remodeling in experimental pulmonary hypertension.

  Life sciences 20121015

• Comparison of metabolism-mediated effects of pyrrolizidine alkaloids in a HepG2/C3A cell-S9 co-incubation system and quantification of their glutathione conjugates.

  Xenobiotica; the fate of foreign compounds in biological systems 20121001

• A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents.

  American journal of respiratory and critical care medicine 20121001

• Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension.

  American journal of respiratory and critical care medicine 20121001

• Benzenesulfonamide attenuates monocrotaline-induced pulmonary arterial hypertension in a rat model.

  European journal of pharmacology 20120905

• Cardiac and vascular atrogin-1 mRNA expression is not associated with dexamethasone efficacy in the monocrotaline model of pulmonary hypertension.

  Cardiovascular toxicology 20120901

• Plumbagin reverses proliferation and resistance to apoptosis in experimental PAH.

  The European respiratory journal 20120901

• Atorvastatin prevents dehydromonocrotaline-induced pulmonary hypertension in beagles.

  Experimental lung research 20120901

• Impaired natural killer cell phenotype and function in idiopathic and heritable pulmonary arterial hypertension.

  Circulation 20120828

• Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.

  Circulation research 20120803

• Attenuation of monocrotaline-induced pulmonary arterial hypertension in rats by rosuvastatin.

  Journal of cardiovascular pharmacology 20120801

• Genistein, a soy phytoestrogen, reverses severe pulmonary hypertension and prevents right heart failure in rats.

  Hypertension (Dallas, Tex. : 1979) 20120801

• Caveolin-1 expression during the progression of pulmonary hypertension.

  Experimental biology and medicine (Maywood, N.J.) 20120801

• The flavonoid monoHER prevents monocrotaline-induced hepatic sinusoidal injury in rats.

  Journal of surgical oncology 20120701

• Effects of purple grape juice in the redox-sensitive modulation of right ventricular remodeling in a pulmonary arterial hypertension model.

  Journal of cardiovascular pharmacology 20120701

• The Rho kinase inhibitor azaindole-1 has long-acting vasodilator activity in the pulmonary vascular bed of the intact chest rat.

  Canadian journal of physiology and pharmacology 20120701

• Reverse right ventricular structural and extracellular matrix remodeling by estrogen in severe pulmonary hypertension.

  Journal of applied physiology (Bethesda, Md. : 1985) 20120701

• Effect of chronic sodium nitrite therapy on monocrotaline-induced pulmonary hypertension.

  Nitric oxide : biology and chemistry 20120630

• Haemodynamic and neuroendocrine effects of tezosentan in chronic experimental pulmonary hypertension.

  Intensive care medicine 20120601

• Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension.

  American journal of physiology. Heart and circulatory physiology 20120601

• Role of Src tyrosine kinases in experimental pulmonary hypertension.

  Arteriosclerosis, thrombosis, and vascular biology 20120601

• Changes of gene expression after bone marrow cell transfusion in rats with monocrotaline-induced pulmonary hypertension.

  Journal of Korean medical science 20120601

• [Pathological changes of monocrotaline-induced pulmonary hypertension in miniature pigs].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120601

• Combined effects of the ATP-sensitive potassium channel opener pinacidil and simvastatin on pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension.

  Die Pharmazie 20120601

• Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.

  Circulation research 20120525

• Mechanical load-dependent cardiac ER stress in vitro and in vivo: effects of preload and afterload.

  FEBS letters 20120507

• Implantation of mesenchymal stem cells improves right ventricular impairments caused by experimental pulmonary hypertension.

  The American journal of the medical sciences 20120501

• Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension.

  American journal of physiology. Lung cellular and molecular physiology 20120501

• [Pathophysiological characteristics of rat pulmonary hypertension and cor pulmonale induced by monocrotaline].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20120501

• Oxygen radicals and substance P in perinatal hypoxia-exaggerated, monocrotaline-induced pulmonary hypertension.

  The Chinese journal of physiology 20120430

• Effects of 2-azafluorenones on phosphatidyl-inositol specific phospholipase C activation in c6 glioma cells.

  The Chinese journal of physiology 20120430

• PAR-2 inhibition reverses experimental pulmonary hypertension.

  Circulation research 20120427

• Cardiac-specific genetic inhibition of nuclear factor-κB prevents right ventricular hypertrophy induced by monocrotaline.

  American journal of physiology. Heart and circulatory physiology 20120415

• Dehydropyrrolizidine alkaloids, including monoesters with an unusual esterifying acid, from cultivated Crotalaria juncea (Sunn Hemp cv.'Tropic Sun').

  Journal of agricultural and food chemistry 20120411

• Fluoxetine protects against monocrotaline-induced pulmonary arterial remodeling by inhibition of hypoxia-inducible factor-1α and vascular endothelial growth factor.

  Canadian journal of physiology and pharmacology 20120401

• Angiotensin-converting enzyme 2 activation protects against pulmonary arterial hypertension through improving early endothelial function and mediating cytokines levels.

  Chinese medical journal 20120401

• Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.

  Cardiovascular research 20120315

• Lung ¹⁸F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension.

  American journal of respiratory and critical care medicine 20120315

• Effects of everolimus in combination with sildenafil in monocrotaline-induced pulmonary hypertension in rats.

  Cardiovascular toxicology 20120301

• Mast cell inhibition improves pulmonary vascular remodeling in pulmonary hypertension.

  Chest 20120301

• Attenuation of the extract from Moringa oleifera on monocrotaline-induced pulmonary hypertension in rats.

  The Chinese journal of physiology 20120227

• The monocrotaline model of pulmonary hypertension in perspective.

  American journal of physiology. Lung cellular and molecular physiology 20120215

• Targeted gene delivery of BMPR2 attenuates pulmonary hypertension.

  The European respiratory journal 20120201

• Spontaneous ventricular fibrillation in right ventricular failure secondary to chronic pulmonary hypertension.

  Circulation. Arrhythmia and electrophysiology 20120201

• Sildenafil prevents and reverses transverse-tubule remodeling and Ca(2+) handling dysfunction in right ventricle failure induced by pulmonary artery hypertension.

  Hypertension (Dallas, Tex. : 1979) 20120201

• Year in review in Intensive Care Medicine 2011: I. Nephrology, epidemiology, nutrition and therapeutics, neurology, ethical and legal issues, experimentals.

  Intensive care medicine 20120201

• [Genistein attenuates monocrotaline-induced pulmonary arterial hypertension in rats by up-regulating heme oxygenase-1 expression].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120201

• Factor VIII can be synthesized in hemophilia A mice liver by bone marrow progenitor cell-derived hepatocytes and sinusoidal endothelial cells.

  Stem cells and development 20120101

• Transgenic expression of human matrix metalloproteinase-1 attenuates pulmonary arterial hypertension in mice.

  Clinical science (London, England : 1979) 20120101

• Fibrosis of pulmonary vascular remodeling in carotid artery-jugular vein shunt pulmonary artery hypertension model of rats.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20120101

• Enhanced store-operated Ca²+ entry and TRPC channel expression in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats.

  American journal of physiology. Cell physiology 20120101

• Development and characterization of an animal model of severe pulmonary arterial hypertension.

  Journal of vascular research 20120101

• Regional skeletal muscle remodeling and mitochondrial dysfunction in right ventricular heart failure.

  American journal of physiology. Heart and circulatory physiology 20120101

• Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle.

  Vascular pharmacology 20120101

• Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension.

  Circulation. Heart failure 20120101

• TGFβ signaling and cardiovascular diseases.

  International journal of biological sciences 20120101

• Effects of autologous bone marrow mononuclear cells implantation in canine model of pulmonary hypertension.

  Circulation journal : official journal of the Japanese Circulation Society 20120101

• New cardiovascular and pulmonary therapeutic strategies based on the Angiotensin-converting enzyme 2/angiotensin-(1-7)/mas receptor axis.

  International journal of hypertension 20120101

• Independent recruitment of a flavin-dependent monooxygenase for safe accumulation of sequestered pyrrolizidine alkaloids in grasshoppers and moths.

  PloS one 20120101

• Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type mice.

  PloS one 20120101

• Comparative potential therapeutic effect of sesame oil and peanut oil against acute monocrotaline (Crotalaria) poisoning in a rat model.

  Journal of veterinary internal medicine 20120101

• Relation of bosentan, iloprost, and sildenafil with growth factor levels in monocrotaline-induced pulmonary hypertension.

  Clinical and experimental hypertension (New York, N.Y. : 1993) 20120101

• Liver disorders in inflammatory bowel disease.

  Gastroenterology research and practice 20120101

• Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension.

  PloS one 20120101

• Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats.

  PloS one 20120101

• Targeting the adventitial microenvironment in pulmonary hypertension: A potential approach to therapy that considers epigenetic change.

  Pulmonary circulation 20120101

• Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension.

  Pulmonary circulation 20120101

• Identification of functional progenitor cells in the pulmonary vasculature.

  Pulmonary circulation 20120101

• Smooth muscle myosin inhibition: a novel therapeutic approach for pulmonary hypertension.

  PloS one 20120101

• Acute effects of vardenafil on pulmonary artery responsiveness in pulmonary hypertension.

  TheScientificWorldJournal 20120101

• Longitudinal in vivo SPECT/CT imaging reveals morphological changes and cardiopulmonary apoptosis in a rodent model of pulmonary arterial hypertension.

  PloS one 20120101

• Activation of the unfolded protein response is associated with pulmonary hypertension.

  Pulmonary circulation 20120101

• The Role of Astrocytes in Metabolism and Neurotoxicity of the Pyrrolizidine Alkaloid Monocrotaline, the Main Toxin of Crotalaria retusa.

  Frontiers in pharmacology 20120101

• Comparison of two experimental models of pulmonary hypertension.

  Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia 20120101

• Nicorandil prevents right ventricular remodeling by inhibiting apoptosis and lowering pressure overload in rats with pulmonary arterial hypertension.

  PloS one 20120101

• Assessment of neurotoxicity of monocrotaline, an alkaloid extracted from Crotalaria retusa in astrocyte/neuron co-culture system.

  Neurotoxicology 20111201

• Association of the time course of pulmonary arterial hypertension with changes in oxidative stress in the left ventricle.

  Clinical and experimental pharmacology & physiology 20111201

• Morphological aspects of neuromuscular junctions and gene expression of nicotinic acetylcholine receptors (nAChRs) in skeletal muscle of rats with heart failure.

  Journal of molecular histology 20111201

• C-122, a novel antagonist of serotonin receptor 5-HT2B, prevents monocrotaline-induced pulmonary arterial hypertension in rats.

  European journal of pharmacology 20111116

• Therapeutic sesamol attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats by inhibiting matrix metalloproteinase-9.

  Cell biochemistry and biophysics 20111101

• ¹H NMR study of monocrotaline and its metabolites in human blood.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111101

• Dehydroepiandrosterone inhibits the Src/STAT3 constitutive activation in pulmonary arterial hypertension.

  American journal of physiology. Heart and circulatory physiology 20111101

• Egr-1 expression during neointimal development in flow-associated pulmonary hypertension.

  The American journal of pathology 20111101

• Evidence of diminished coronary flow in pulmonary hypertension: explaining angina pectoris in this patient group?

  Clinical physiology and functional imaging 20111101

• Stem-cell therapy in an experimental model of pulmonary hypertension and right heart failure: role of paracrine and neurohormonal milieu in the remodeling process.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20111101

• Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease.

  The Journal of clinical investigation 20111101

• Silencing of tissue factor by antisense deoxyoligonucleotide prevents monocrotaline/LPS renal injury in mice.

  Archives of toxicology 20111001

• Matrix metalloproteinase-2 (MMP-2) and membrane-type 1 MMP (MT1-MMP) affect the remodeling of glomerulosclerosis in diabetic OLETF rats.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20111001

• A role for coagulation factor Xa in experimental pulmonary arterial hypertension.

  Cardiovascular research 20111001

• Advances in tenascin-C biology.

  Cellular and molecular life sciences : CMLS 20111001

• Alteration of pulmonary artery integrin levels in chronic hypoxia and monocrotaline-induced pulmonary hypertension.

  Journal of vascular research 20111001

• Simvastatin protects against the development of monocrotaline-induced pulmonary hypertension in rats via a heme oxygenase-1-dependent pathway.

  Experimental lung research 20111001

• The relationship between structurally different pyrrolizidine alkaloids and western flower thrips resistance in F(2) hybrids of Jacobaea vulgaris and Jacobaea aquatica.

  Journal of chemical ecology 20111001

• Influence of estrogen on pulmonary arterial hypertension: role of oxidative stress.

  Cell biochemistry and function 20111001

• [Determination of pulmonary vascular resistance by improved right heart catheter in rat].

  Zhonghua xin xue guan bing za zhi 20111001

• Efficacy of aminaftone in a rat model of monocrotaline-induced pulmonary hypertension.

  European journal of pharmacology 20110930

• Estrogen rescues preexisting severe pulmonary hypertension in rats.

  American journal of respiratory and critical care medicine 20110915

• Oxidized low-density lipoprotein and tissue factor are involved in monocrotaline/lipopolysaccharide-induced hepatotoxicity.

  Archives of toxicology 20110901

• Aspirin attenuates pulmonary arterial hypertension in rats by reducing plasma 5-hydroxytryptamine levels.

  Cell biochemistry and biophysics 20110901

• Rosuvastatin attenuates monocrotaline-induced pulmonary hypertension via regulation of Akt/eNOS signaling and asymmetric dimethylarginine metabolism.

  European journal of pharmacology 20110901

• Intralipid prevents and rescues fatal pulmonary arterial hypertension and right ventricular failure in rats.

  Hypertension (Dallas, Tex. : 1979) 20110901

• Changes of pulmonary pathology and gene expressions after simvastatin treatment in the monocrotaline-induced pulmonary hypertension rat model.

  Korean circulation journal 20110901

• Urantide alleviates monocrotaline induced pulmonary arterial hypertension in Wistar rats.

  Pulmonary pharmacology & therapeutics 20110801

• Rapid quantification of myocardial fibrosis: a new macro-based automated analysis.

  Cellular oncology (Dordrecht) 20110801

• Levosimendan attenuates pulmonary vascular remodeling.

  Intensive care medicine 20110801

• Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase.

  Hypertension (Dallas, Tex. : 1979) 20110801

• Rodent models of pulmonary hypertension: harmonisation with the world health organisation's categorisation of human PH.

  International journal of clinical practice. Supplement 20110801

• Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension.

  Journal of molecular medicine (Berlin, Germany) 20110801

• [Transplantation of marrow mesenchymal stem cells transfected with vascular endothelial growth factor gene for the treatment of pulmonary hypertension in rats].

  Zhonghua yi xue za zhi 20110712

• Perivascular T-cell infiltration leads to sustained pulmonary artery remodeling after endothelial cell damage.

  American journal of respiratory cell and molecular biology 20110701

• Treatment of pulmonary arterial hypertension with circulating angiogenic cells.

  American journal of physiology. Lung cellular and molecular physiology 20110701

• Tissue factor dependent liver injury causes release of retinoid receptors (RXR-α and RAR-α) as lipid droplets.

  Biochemical and biophysical research communications 20110624

• Mast cells promote lung vascular remodelling in pulmonary hypertension.

  The European respiratory journal 20110601

• Arrhythmogenic substrate in hearts of rats with monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy.

  American journal of physiology. Heart and circulatory physiology 20110601

• Downregulation of osteopontin is associated with fluoxetine amelioration of monocrotaline-induced pulmonary inflammation and vascular remodelling.

  Clinical and experimental pharmacology & physiology 20110601

• Dexamethasone attenuates development of monocrotaline-induced pulmonary arterial hypertension.

  Molecular biology reports 20110601

• Differential morphofunctional characteristics and gene expression in fast and slow muscle of rats with monocrotaline-induced heart failure.

  Journal of molecular histology 20110601

• Cytotoxicity of monocrotaline in isolated rat hepatocytes: effects of dithiothreitol and fructose.

  Toxicon : official journal of the International Society on Toxinology 20110601

• Peptide-directed highly selective targeting of pulmonary arterial hypertension.

  The American journal of pathology 20110601

• Diaphragm muscle fiber weakness in pulmonary hypertension.

  American journal of respiratory and critical care medicine 20110515

• Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.

  The European respiratory journal 20110501

• New perspectives for the treatment of pulmonary hypertension.

  British journal of pharmacology 20110501

• Involvement of BMPR2 in the protective effect of fluoxetine against monocrotaline-induced endothelial apoptosis in rats.

  Canadian journal of physiology and pharmacology 20110501

• [Studies on the alkaloids of Senecio scandens growing in Guangdong].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110501

• Impact of pulmonary vascular resistances in heart transplantation for congenital heart disease.

  Current cardiology reviews 20110501

• Dexamethasone reverses monocrotaline-induced pulmonary arterial hypertension in rats.

  The European respiratory journal 20110401

• Suppression of tissue inhibitors of metalloproteinases may reverse severe pulmonary arterial hypertension.

  Cytotherapy 20110401

• Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension.

  Journal of applied physiology (Bethesda, Md. : 1985) 20110401

• Hepatocyte growth factor improves the survival of rats with pulmonary arterial hypertension via the amelioration of pulmonary hemodynamics.

  International journal of molecular medicine 20110401

• Doppler flow spectra of the superior vena cava in a rat model of chronic pulmonary hypertension.

  Laboratory animals 20110401

• Effects of simvastatin on pulmonary C-fiber sensitivity in rats with monocrotaline-induced pulmonary hypertension.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20110301

• Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase activator, BAY 60-2770, are not dependent on endogenous nitric oxide or reduced heme.

  American journal of physiology. Heart and circulatory physiology 20110301

• [Effects of rosuvastatin on monocrotaline-induced pulmonary artery hypertension in rats].

  Zhonghua xin xue guan bing za zhi 20110301

• [Evaluation of vitro hepatotoxicity of monocrotaline by precision-cut liver slice technique].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110301

• [Simultaneous quantitation of adonifoline and senecionine in Senecio herbs by UPLC-MS].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110301

• Right ventricular failure following chronic pressure overload is associated with reduction in left ventricular mass: evidence for atrophic remodeling.

  Journal of the American College of Cardiology 20110222

• Transgenic expression of human matrix metalloproteinase-9 augments monocrotaline-induced pulmonary arterial hypertension in mice.

  Journal of hypertension 20110201

• Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats.

  Acta pharmacologica Sinica 20110201

• Nanoparticle-mediated delivery of pitavastatin into lungs ameliorates the development and induces regression of monocrotaline-induced pulmonary artery hypertension.

  Hypertension (Dallas, Tex. : 1979) 20110201

• Emerging pathogenetic mechanisms of pulmonary arterial hypertension: nitric oxide and more.

  Korean circulation journal 20110201

• Gene expressions of nitric oxide synthase and matrix metalloproteinase-2 in monocrotaline-induced pulmonary hypertension in rats after bosentan treatment.

  Korean circulation journal 20110201

• [Toxicity of monocrotaline on in vitro cultured mouse embryos].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110201

• The effects of antiangiogenic compound SU5416 in a rat model of pulmonary arterial hypertension.

  Respiration; international review of thoracic diseases 20110101

• Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy.

  The American journal of pathology 20110101

• Pressure load: the main factor for altered gene expression in right ventricular hypertrophy in chronic hypoxic rats.

  PloS one 20110101

• Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung.

  Respiratory research 20110101

• The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline.

  International journal of nanomedicine 20110101

• Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model.

  Respiratory research 20110101

• Ang-(1-7) might prevent the development of monocrotaline induced pulmonary arterial hypertension in rats.

  European review for medical and pharmacological sciences 20110101

• Role of the gap junctions in the contractile response to agonists in pulmonary artery from two rat models of pulmonary hypertension.

  Respiratory research 20110101

• Acceleration of Ca2+ waves in monocrotaline-induced right ventricular hypertrophy in the rat.

  Circulation journal : official journal of the Japanese Circulation Society 20110101

• [A sharp increase in the density of pulmonary and pericardial mast cells under monocrotaline-induced pulmonary hypertension in rats].

  Tsitologiia 20110101

• Prospect of vasoactive intestinal peptide therapy for COPD/PAH and asthma: a review.

  Respiratory research 20110101

• Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling.

  PloS one 20110101

• Pulmonary arterial dysfunction in insulin resistant obese Zucker rats.

  Respiratory research 20110101

• Glycogen synthase kinase 3beta contributes to proliferation of arterial smooth muscle cells in pulmonary hypertension.

  PloS one 20110101

• MicroRNA let-7f inhibits tumor invasion and metastasis by targeting MYH9 in human gastric cancer.

  PloS one 20110101

• Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats.

  Respiratory research 20110101

• Recent trends in pulmonary arterial hypertension.

  Lung India : official organ of Indian Chest Society 20110101

• Cell-specific dual role of caveolin-1 in pulmonary hypertension.

  Pulmonary medicine 20110101

• Therapeutic strategies in pulmonary hypertension.

  Frontiers in pharmacology 20110101

• ACE2 improves right ventricular function in a pressure overload model.

  PloS one 20110101

• What is new for an old molecule? Systematic review and recommendations on the use of resveratrol.

  PloS one 20110101

• Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension.

  Respiratory research 20110101

• Novel interventional approaches for ALI/ARDS: cell-based gene therapy.

  Mediators of inflammation 20110101

• Angiogenesis gene expression in murine endothelial cells during post-pneumonectomy lung growth.

  Respiratory research 20110101

• Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling.

  Respiratory research 20110101

• Pulmonary oxidative stress is increased in cyclooxygenase-2 knockdown mice with mild pulmonary hypertension induced by monocrotaline.

  PloS one 20110101

• Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension.

  Respiratory research 20110101

• Krüppel-like factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension.

  Respiratory research 20110101

• Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells.

  Respiratory research 20110101

• VIP and endothelin receptor antagonist: an effective combination against experimental pulmonary arterial hypertension.

  Respiratory research 20110101

• Progenitor cells in pulmonary vascular remodeling.

  Pulmonary circulation 20110101

• Protein trafficking dysfunctions: Role in the pathogenesis of pulmonary arterial hypertension.

  Pulmonary circulation 20110101

• Combination use of sildenafil and simvastatin increases BMPR-II signal transduction in rats with monocrotaline-mediated pulmonary hypertension.

  Pulmonary circulation 20110101

• Transgenic mice over-expressing ET-1 in the endothelial cells develop systemic hypertension with altered vascular reactivity.

  PloS one 20110101

• Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia.

  PloS one 20110101

• The genetics of pulmonary arterial hypertension in the post-BMPR2 era.

  Pulmonary circulation 20110101

• Apelin and pulmonary hypertension.

  Pulmonary circulation 20110101

• Epigenetic mechanisms of pulmonary hypertension.

  Pulmonary circulation 20110101

• MicroRNAs-control of essential genes: Implications for pulmonary vascular disease.

  Pulmonary circulation 20110101

• Pharmacogenomics in pulmonary arterial hypertension: Toward a mechanistic, target-based approach to therapy.

  Pulmonary circulation 20110101

• Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females.

  Respiratory research 20110101

• Treatment with LA-419 prevents monocrotaline-induced pulmonary hypertension and lung injury in the rat.

  Proceedings of the Western Pharmacology Society 20110101

• Reversible or irreversible remodeling in pulmonary arterial hypertension.

  American journal of respiratory cell and molecular biology 20101201

• Gene delivery of cytochrome p450 epoxygenase ameliorates monocrotaline-induced pulmonary artery hypertension in rats.

  American journal of respiratory cell and molecular biology 20101201

• A predictive ligand-based Bayesian model for human drug-induced liver injury.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Urotensin II receptor antagonist attenuates monocrotaline-induced cardiac hypertrophy in rats.

  American journal of physiology. Heart and circulatory physiology 20101201

• [Comparison of the hepatic veno-occlusive disease models induced by gynura segetum, monocrotaline and cyclophosphamide].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20101201

• Simvastatin, sildenafil and their combination in monocrotaline induced pulmonary arterial hypertension.

  Korean circulation journal 20101201

• Innate immunity in the therapeutic actions of endothelial progenitor cells in pulmonary hypertension.

  American journal of respiratory cell and molecular biology 20101101

• Effects of atorvastatin and L-arginine treatments on electrical field stimulation-mediated relaxations in pulmonary arterial rings of monocrotaline-induced pulmonary hypertensive rats.

  Journal of cardiovascular pharmacology 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Synergistic therapeutic effects of 2-methoxyestradiol with either sildenafil or bosentan on amelioration of monocrotaline-induced pulmonary hypertension and vascular remodeling.

  Journal of cardiovascular pharmacology 20101101

• Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in rats.

  Circulation 20101101

• Contribution of oxidative stress to pulmonary arterial hypertension.

  World journal of cardiology 20101026

• The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension.

  American journal of respiratory and critical care medicine 20101015

• Combination of sildenafil and simvastatin ameliorates monocrotaline-induced pulmonary hypertension in rats.

  Pulmonary pharmacology & therapeutics 20101001

• Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil.

  The European respiratory journal 20101001

• Downregulation of oxytocin receptors in right ventricle of rats with monocrotaline-induced pulmonary hypertension.

  Acta physiologica (Oxford, England) 20101001

• Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension.

  The European respiratory journal 20101001

• The effects of atorvastatin on pulmonary arterial hypertension and expression of p38, p27, and Jab1 in rats.

  International journal of molecular medicine 20101001

• Differential cellular responses to protein adducts of naphthoquinone and monocrotaline pyrrole.

  Chemical research in toxicology 20100920

• Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats.

  American journal of respiratory and critical care medicine 20100901

• Analysis of heart rate variability in a rat model of induced pulmonary hypertension.

  Medical engineering & physics 20100901

• Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension.

  American journal of physiology. Lung cellular and molecular physiology 20100901

• Developing and characterizing a mouse model of hepatotoxicity using oral pyrrolizidine alkaloid (monocrotaline) administration, with potentiation of the liver injury by co-administration of LPS.

  Natural product communications 20100901

• Drug off-target effects predicted using structural analysis in the context of a metabolic network model.

  PLoS computational biology 20100901

• Gene expression of endothelin-1 and endothelin receptor a on monocrotaline-induced pulmonary hypertension in rats after bosentan treatment.

  Korean circulation journal 20100901

• Skeletal muscle proteins oxidation in chronic right heart failure in rats: can different beta-blockers prevent it to the same degree?

  International journal of cardiology 20100820

• Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension.

  Science translational medicine 20100811

• PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats.

  The Journal of pharmacology and experimental therapeutics 20100801

• Consistency of predictive signature genes and classifiers generated using different microarray platforms.

  The pharmacogenomics journal 20100801

• Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.

  Circulation research 20100723

• Determination of endothelin-1 in rats using a high-performance liquid chromatography coupled to electrospray tandem mass spectrometry.

  Talanta 20100715

• Analysis of responses to the Rho-kinase inhibitor Y-27632 in the pulmonary and systemic vascular bed of the rat.

  American journal of physiology. Heart and circulatory physiology 20100701

• Early inflammatory response during the development of right ventricular heart failure in a rat model.

  European journal of heart failure 20100701

• Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension.

  Experimental biology and medicine (Maywood, N.J.) 20100701

• A comparison of echocardiography to invasive measurement in the evaluation of pulmonary arterial hypertension in a rat model.

  The international journal of cardiovascular imaging 20100601

• L-arginine restores endothelial nitric oxide synthase-coupled activity and attenuates monocrotaline-induced pulmonary artery hypertension in rats.

  American journal of physiology. Endocrinology and metabolism 20100601

• Sildenafil limits monocrotaline-induced pulmonary hypertension in rats through suppression of pulmonary vascular remodeling.

  Journal of cardiovascular pharmacology 20100601

• The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase.

  British journal of pharmacology 20100601

• KMUP-1 ameliorates monocrotaline-induced pulmonary arterial hypertension through the modulation of Ca2+ sensitization and K+-channel.

  Life sciences 20100508

• Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats.

  Basic research in cardiology 20100501

• Gene expression profile in flow-associated pulmonary arterial hypertension with neointimal lesions.

  American journal of physiology. Lung cellular and molecular physiology 20100401

• Pulmonary hypertension is ameliorated in mice deficient in thrombin-activatable fibrinolysis inhibitor.

  Journal of thrombosis and haemostasis : JTH 20100401

• Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline.

  Arteriosclerosis, thrombosis, and vascular biology 20100401

• Reduced mechanical efficiency of rat papillary muscle related to degree of hypertrophy of cardiomyocytes.

  American journal of physiology. Heart and circulatory physiology 20100401

• Sodium valproate, a histone deacetylase inhibitor, but not captopril, prevents right ventricular hypertrophy in rats.

  Circulation journal : official journal of the Japanese Circulation Society 20100401

• High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of pyrrolizidine alkaloid-derived DNA adducts in vitro and in vivo.

  Chemical research in toxicology 20100315

• Glucuronidation, a new metabolic pathway for pyrrolizidine alkaloids.

  Chemical research in toxicology 20100315

• Cardiomyocyte-specific inactivation of thyroid hormone in pathologic ventricular hypertrophy: an adaptative response or part of the problem?

  Heart failure reviews 20100301

• Antioxidant treatment attenuates pulmonary arterial hypertension-induced heart failure.

  American journal of physiology. Heart and circulatory physiology 20100301

• A high-calorie diet attenuates cachexia and adipose tissue inflammation in monocrotaline-induced pulmonary hypertensive rats.

  Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20100301

• [TRPC6 mediates the enhancements of pulmonary arterial tone and intracellular Ca2+ concentration of pulmonary arterial smooth muscle cells in pulmonary hypertension rats].

  Sheng li xue bao : [Acta physiologica Sinica] 20100225

• Resveratrol inhibits right ventricular hypertrophy induced by monocrotaline in rats.

  Clinical and experimental pharmacology & physiology 20100201

• Impaired vasoconstriction and nitric oxide-mediated relaxation in pulmonary arteries of hypoxia- and monocrotaline-induced pulmonary hypertensive rats.

  The Journal of pharmacology and experimental therapeutics 20100201

• The enzymatic degradation of hyaluronan is associated with disease progression in experimental pulmonary hypertension.

  American journal of physiology. Lung cellular and molecular physiology 20100201

• Progressive endothelial cell damage in an inflammatory model of pulmonary hypertension.

  Experimental lung research 20100201

• Heart failure increases atrogin-1 and MuRF1 gene expression in skeletal muscle with fiber type-specific atrophy.

  Journal of molecular histology 20100201

• Ghrelin and cardiovascular diseases.

  Current cardiology reviews 20100201

• Role of epidermal growth factor inhibition in experimental pulmonary hypertension.

  American journal of respiratory and critical care medicine 20100115

• Retrorsine, but not monocrotaline, is a mechanism-based inactivator of P450 3A4.

  Chemico-biological interactions 20100105

• Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase-dependent nitric oxide generation.

  Circulation 20100105

• The effects and mechanisms of mycophenolate mofetil on pulmonary arterial hypertension in rats.

  Rheumatology international 20100101

• Poisoning of sheep by seeds of Crotalaria retusa: acquired resistance by continuous administration of low doses.

  Toxicon : official journal of the International Society on Toxinology 20100101

• Genotoxicity and morphological changes induced by the alkaloid monocrotaline, extracted from Crotalaria retusa, in a model of glial cells.

  Toxicon : official journal of the International Society on Toxinology 20100101

• Modulation of monocrotaline-induced cor pulmonale by grape juice.

  Journal of cardiovascular pharmacology 20100101

• The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle.

  Journal of molecular medicine (Berlin, Germany) 20100101

• Pulmonary hemodynamic response to acute combination and monotherapy with sildenafil and brain natriuretic peptide in rats with monocrotaline-induced pulmonary hypertension.

  The American journal of the medical sciences 20100101

• The extracellular signal-regulated kinase is involved in the effects of sildenafil on pulmonary vascular remodeling.

  Cardiovascular therapeutics 20100101

• Polyamine regulatory pathways as pharmacologic targets in pulmonary arterial hypertension.

  Advances in experimental medicine and biology 20100101

• The PPARbeta/delta agonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension.

  PloS one 20100101

• Novel approaches to treat experimental pulmonary arterial hypertension: a review.

  Journal of biomedicine & biotechnology 20100101

• Estrogen-induced relaxation of the rat tail artery is attenuated in rats with pulmonary hypertension.

  Pharmacological reports : PR 20100101

• Idiopathic pulmonary arterial hypertension.

  Disease models & mechanisms 20100101

• Flavin-dependent monooxygenases as a detoxification mechanism in insects: new insights from the arctiids (lepidoptera).

  PloS one 20100101

• Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELM alpha) recruits bone marrow-derived cells to the murine pulmonary vasculature.

  PloS one 20100101

• Dose-dependent therapeutic effects of 2-Methoxyestradiol on Monocrotaline-Induced pulmonary hypertension and vascular remodelling.

  Prilozi 20100101

• Involvement of asymmetric dimethylarginine and Rho kinase in the vascular remodeling in monocrotaline-induced pulmonary hypertension.

  Vascular pharmacology 20100101

• KMUP-1 inhibits pulmonary artery proliferation by targeting serotonin receptors/transporter and NO synthase, inactivating RhoA and suppressing AKT/ERK phosphorylation.

  Vascular pharmacology 20100101

• Systemic evaluation of platelet and leukocyte activation and interaction in a rat model of pulmonary arterial hypertension.

  Cardiology 20100101

• Genetics of pulmonary arterial hypertension: do the molecular findings have translational value?

  F1000 biology reports 20100101

• Rapid quantification of myocardial fibrosis: A new macro-based automated analysis.

  Analytical cellular pathology (Amsterdam) 20100101

• Interleukin-6 as a potential therapeutic target for pulmonary arterial hypertension.

  International journal of rheumatology 20100101

• Diesel engine exhaust initiates a sequence of pulmonary and cardiovascular effects in rats.

  Journal of toxicology 20100101

• Transforming growth factor-β inhibition attenuates pulmonary arterial hypertension in rats.

  International journal of clinical and experimental medicine 20100101

• Effects of atorvastatin and losartan on monocrotaline-induced pulmonary artery remodeling in rats.

  Clinical and experimental hypertension (New York, N.Y. : 1993) 20100101

• Biochemistry and occurrence of o-demethylation in plant metabolism.

  Frontiers in physiology 20100101

• Ayurveda and cancer.

  Pharmacognosy research 20100101

• Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure.

  American journal of physiology. Lung cellular and molecular physiology 20091201

• Effects of a pure alpha/beta-adrenergic receptor blocker on monocrotaline-induced pulmonary arterial hypertension with right ventricular hypertrophy in rats.

  Circulation journal : official journal of the Japanese Circulation Society 20091201

• Alterations in dystrophin-related glycoproteins in development of right ventricular failure in rats.

  Journal of pharmacological sciences 20091201

• Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database.

  Toxicology 20091109

• Senescent endothelial progenitor cells from dogs with pulmonary arterial hypertension: a before-after self-controlled study.

  The journal of physiological sciences : JPS 20091101

• Right ventricular pacing improves right heart function in experimental pulmonary arterial hypertension: a study in the isolated heart.

  American journal of physiology. Heart and circulatory physiology 20091101

• Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension.

  American journal of physiology. Heart and circulatory physiology 20091101

• Tadalafil, a long-acting inhibitor of PDE5, improves pulmonary hemodynamics and survival rate of monocrotaline-induced pulmonary artery hypertension in rats.

  Journal of pharmacological sciences 20091101

• [Testosterone therapy improves cardiac function of male rats with right heart failure].

  Zhonghua nan ke xue = National journal of andrology 20091101

• Intracellular glutathione plays important roles in pyrrolizidine alkaloids-induced growth inhibition on hepatocytes.

  Environmental toxicology and pharmacology 20091101

• Evaluation of the simvastatin effects in the treatment of pulmonary hypertension (PH).

  Lijecnicki vjesnik 20091101

• Golgi, trafficking, and mitosis dysfunctions in pulmonary arterial endothelial cells exposed to monocrotaline pyrrole and NO scavenging.

  American journal of physiology. Lung cellular and molecular physiology 20091001

• Effects of telmisartan on right ventricular remodeling induced by monocrotaline in rats.

  Journal of pharmacological sciences 20091001

• Time course and mechanisms of left ventricular systolic and diastolic dysfunction in monocrotaline-induced pulmonary hypertension.

  Basic research in cardiology 20090901

• Cirrhosis ameliorates monocrotaline-induced pulmonary hypertension in rats.

  The European respiratory journal 20090901

• Early combined treatment with cilostazol and bone marrow-derived endothelial progenitor cells markedly attenuates pulmonary arterial hypertension in rats.

  The Journal of pharmacology and experimental therapeutics 20090901

• Is resveratrol the magic bullet for pulmonary hypertension?

  Hypertension (Dallas, Tex. : 1979) 20090901

• Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats.

  Hypertension (Dallas, Tex. : 1979) 20090901

• Propylthiouracil attenuates monocrotaline-induced pulmonary arterial hypertension in rats.

  Circulation journal : official journal of the Japanese Circulation Society 20090901

• Possible involvement of mitochondrial energy-producing ability in the development of right ventricular failure in monocrotaline-induced pulmonary hypertensive rats.

  Journal of pharmacological sciences 20090901

• Feeding deterrence and detrimental effects of pyrrolizidine alkaloids fed to honey bees (Apis mellifera).

  Journal of chemical ecology 20090901

• Monocrotaline-induced pulmonary hypertension in Wistar rats.

  Current protocols in pharmacology 20090901

• [Administrating bone marrow mesenchymal stem cells to treat the experimental pulmonary arterial hypertension in rats].

  Zhonghua yi xue za zhi 20090811

• Fluoxetine protects against monocrotaline-induced pulmonary arterial hypertension: potential roles of induction of apoptosis and upregulation of Kv1.5 channels in rats.

  Clinical and experimental pharmacology & physiology 20090801

• Bone marrow progenitor cells repair rat hepatic sinusoidal endothelial cells after liver injury.

  Gastroenterology 20090801

• Continuous fluoxetine administration prevents recurrence of pulmonary arterial hypertension and prolongs survival in rats.

  Clinical and experimental pharmacology & physiology 20090801

• Change in pharmacological effect of endothelin receptor antagonists in rats with pulmonary hypertension: role of ETB-receptor expression levels.

  Pulmonary pharmacology & therapeutics 20090801

• Prevention of pulmonary hypertension by Angiotensin-converting enzyme 2 gene transfer.

  Hypertension (Dallas, Tex. : 1979) 20090801

• Serial noninvasive assessment of apoptosis during right ventricular disease progression in rats.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090801

• Syngeneic bone marrow mononuclear cells improve pulmonary arterial hypertension through vascular endothelial growth factor upregulation.

  The Annals of thoracic surgery 20090801

• Alterations in pharmacological action of the right ventricle of monocrotaline-induced pulmonary hypertensive rats.

  Biological & pharmaceutical bulletin 20090801

• Retraction. Reliable experimental model of hepatic veno-occlusive disease caused by monocrotaline.

  Hepatobiliary & pancreatic diseases international : HBPD INT 20090801

• Temporal changes of angiopoietins and Tie2 expression in rat lungs after monocrotaline-induced pulmonary hypertension.

  Comparative medicine 20090801

• Discriminating pulmonary hypertension caused by monocrotaline toxicity from chronic hypoxia by near-infrared spectroscopy and multivariate methods of analysis.

  Analytical biochemistry 20090715

• Opposite effects of training in rats with stable and progressive pulmonary hypertension.

  Circulation 20090707

• Dehydromonocrotaline induces cyclosporine A-insensitive mitochondrial permeability transition/cytochrome c release.

  Toxicon : official journal of the International Society on Toxinology 20090701

• Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats.

  Molecular therapy : the journal of the American Society of Gene Therapy 20090701

• Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor.

  The Journal of pharmacology and experimental therapeutics 20090701

• Effects of pyrrolizidine alkaloids on the performance of plant-parasitic and free-living nematodes.

  Pest management science 20090701

• Preventive effects of raloxifene, a selective estrogen receptor modulator, on monocrotaline-induced pulmonary hypertension in intact and ovariectomized female rats.

  European journal of pharmacology 20090701

• Effects of roflumilast, a phosphodiesterase-4 inhibitor, on hypoxia- and monocrotaline-induced pulmonary hypertension in rats.

  The Journal of pharmacology and experimental therapeutics 20090701

• Endothelin receptor blockade combined with phosphodiesterase-5 inhibition increases right ventricular mitochondrial capacity in pulmonary arterial hypertension.

  American journal of physiology. Heart and circulatory physiology 20090701

• Changes in pulmonary blood flow distribution in monocrotaline compared with hypoxia-induced models of pulmonary hypertension: assessed using synchrotron radiation.

  Journal of hypertension 20090701

• Molecular imaging of monocrotaline-induced pulmonary vascular disease with radiolabeled linear adrenomedullin.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090701

• [B-type natriuretic peptide (BNP) levels and the effects of carvedilol on BNP levels in juvenile rats with right heart failure].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20090701

• Progesterone inhibits vascular remodeling and attenuates monocrotaline-induced pulmonary hypertension in estrogen-deficient rats.

  Prilozi 20090701

• Marrow cell infusion attenuates vascular remodeling in a murine model of monocrotaline-induced pulmonary hypertension.

  Stem cells and development 20090601

• Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension.

  American journal of respiratory and critical care medicine 20090601

• Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension.

  American journal of physiology. Heart and circulatory physiology 20090601

• Hepatic regeneration is decreased in a rat model of sinusoidal obstruction syndrome.

  Journal of surgical oncology 20090601

• Cardiac lesions induced by testosterone: protective effects of dexrazoxane and trimetazidine.

  Cardiovascular toxicology 20090601

• A novel therapeutic strategy for liver sinusoidal obstruction syndrome.

  Journal of gastroenterology and hepatology 20090601

• Dai-kenchu-to attenuates rat sinusoidal obstruction syndrome by inhibiting the accumulation of neutrophils in the liver.

  Journal of gastroenterology and hepatology 20090601

• Establishment of rat model of cardiopulmonary bypass in pulmonary hypertension.

  Asian cardiovascular & thoracic annals 20090601

• Simvastatin restores down-regulated GATA-6 expression in pulmonary hypertensive rats.

  Experimental lung research 20090601

• Nanoparticle-mediated delivery of nuclear factor kappaB decoy into lungs ameliorates monocrotaline-induced pulmonary arterial hypertension.

  Hypertension (Dallas, Tex. : 1979) 20090501

• A phosphodiesterase III inhibitor protects rat liver from sinusoidal obstruction syndrome through heme oxygenase-1 induction.

  Annals of surgery 20090501

• Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular remodelling.

  Cardiovascular research 20090401

• [Simvastatin prevents the development of pulmonary hypertension in the rats through reduction of inflammation].

  Zhonghua yi xue za zhi 20090331

• Warning displays may function as honest signals of toxicity.

  Proceedings. Biological sciences 20090307

• Galphaq-protein carboxyl terminus imitation polypeptide (GCIP)-27 inhibits right ventricular hypertrophy induced by monocrotaline in rats.

  Biological & pharmaceutical bulletin 20090301

• Pulmonary hypertension modifies responsiveness of sinoatrial cells of rat hearts to adrenomimetics and activators of ATP-sensitive K+ channels in a gender-dependent way.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090301

• Low doses of monocrotaline in rats cause diminished bone marrow cellularity and compromised nitric oxide production by peritoneal macrophages.

  Journal of immunotoxicology 20090301

• 3-Hydroxy-3-methylglutaryl (HMG)-COA reductase inhibitors and phosphodiesterase type V inhibitors attenuate right ventricular pressure and remodeling in a rat model of pulmonary hypertension.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20090204

• Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease.

  Circulation 20090203

• CPU0213, a non-selective ETA/ETB receptor antagonist, improves pulmonary arteriolar remodeling of monocrotaline-induced pulmonary hypertension in rats.

  Clinical and experimental pharmacology & physiology 20090201

• Molecular and electrical remodeling of L- and T-type Ca(2+) channels in rat right atrium with monocrotaline-induced pulmonary hypertension.

  Circulation journal : official journal of the Japanese Circulation Society 20090201

• Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline.

  The American journal of pathology 20090201

• Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats.

  Journal of hypertension 20090201

• From arginine methylation to ADMA: a novel mechanism with therapeutic potential in chronic lung diseases.

  BMC pulmonary medicine 20090101

• Characterization of erectile function in monocrotaline-treated pulmonary hypertensive rats.

  Journal of andrology 20090101

• The remodeling of connexin in the hypertrophied right ventricular in pulmonary arterial hypertension and the effect of a dual ET receptor antagonist (bosentan).

  Pathology, research and practice 20090101

• Self-medication as adaptive plasticity: increased ingestion of plant toxins by parasitized caterpillars.

  PloS one 20090101

• Simvastatin ameliorates established pulmonary hypertension through a heme oxygenase-1 dependent pathway in rats.

  Respiratory research 20090101

• Serum VEGF levels are related to the presence of pulmonary arterial hypertension in systemic sclerosis.

  BMC pulmonary medicine 20090101

• Inhaled iloprost for the control of pulmonary hypertension.

  Vascular health and risk management 20090101

• Discernment of possible mechanisms of hepatotoxicity via biological processes over-represented by co-expressed genes.

  BMC genomics 20090101

• Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia.

  PloS one 20090101

• Treatment of pediatric pulmonary hypertension.

  Vascular health and risk management 20090101

• Caveolin-1 Expression and Hemodynamics in COPD Patients.

  The open respiratory medicine journal 20090101

• Protective effects of hydroalcoholic extract from rhizomes of Cynodon dactylon (L.) Pers. on compensated right heart failure in rats.

  BMC complementary and alternative medicine 20090101

• RhoA/Rho-kinase signaling: a therapeutic target in pulmonary hypertension.

  Vascular health and risk management 20090101

• Pressure overload-induced right ventricular failure is associated with re-expression of myocardial tenascin-C and elevated plasma tenascin-C levels.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101

• Update on pulmonary hypertension complicating chronic obstructive pulmonary disease.

  International journal of chronic obstructive pulmonary disease 20090101

• Inhibition of SOC/Ca2+/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells.

  Respiratory research 20090101

• Anti-TNF treatment reduces rat skeletal muscle wasting in monocrotaline-induced cardiac cachexia.

  Journal of applied physiology (Bethesda, Md. : 1985) 20081201

• Upregulation of GLUT-4 in right ventricle of rats with monocrotaline-induced pulmonary hypertension.

  Medical science monitor : international medical journal of experimental and clinical research 20081201

• Captopril attenuates matrix metalloproteinase-2 and -9 in monocrotaline-induced right ventricular hypertrophy in rats.

  Journal of pharmacological sciences 20081201

• Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling.

  Circulation 20081111

• Effects of monocrotaline on energy metabolism in the rat liver.

  Toxicology letters 20081110

• Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat.

  American journal of physiology. Lung cellular and molecular physiology 20081101

• Endothelin-3-dependent pulmonary vasoconstriction in monocrotaline-induced pulmonary arterial hypertension.

  Peptides 20081101

• Depletion of the ATPase NSF from Golgi membranes with hypo-S-nitrosylation of vasorelevant proteins in endothelial cells exposed to monocrotaline pyrrole.

  American journal of physiology. Heart and circulatory physiology 20081101

• Hemin treatment abrogates monocrotaline-induced pulmonary hypertension.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20081101

• Novel approach with intratracheal administration of microgelatin hydrogel microspheres incorporating basic fibroblast growth factor for rescue of rats with monocrotaline-induced pulmonary hypertension.

  The Journal of thoracic and cardiovascular surgery 20081101

• Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension.

  British journal of pharmacology 20081001

• Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension.

  The European respiratory journal 20081001

• Effects of endogenous sulfur dioxide on monocrotaline-induced pulmonary hypertension in rats.

  Acta pharmacologica Sinica 20081001

• m-Nisoldipine attenuates monocrotaline-induced pulmonary hypertension by suppressing 5-HT/ERK MAPK pathway.

  Yao xue xue bao = Acta pharmaceutica Sinica 20081001

• Involvement of Bcl-xL degradation and mitochondrial-mediated apoptotic pathway in pyrrolizidine alkaloids-induced apoptosis in hepatocytes.

  Toxicology and applied pharmacology 20080915

• Thymulin inhibits monocrotaline-induced pulmonary hypertension modulating interleukin-6 expression and suppressing p38 pathway.

  Endocrinology 20080901

• Celecoxib but not the combination of celecoxib+atorvastatin prevents the development of monocrotaline-induced pulmonary hypertension in the rat.

  Naunyn-Schmiedeberg's archives of pharmacology 20080901

• A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses of its active form, {4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic acid (MRE-269), on rat pulmonary artery.

  The Journal of pharmacology and experimental therapeutics 20080901

• Effects of a chronic exercise training protocol on oxidative stress and right ventricular hypertrophy in monocrotaline-treated rats.

  Clinical and experimental pharmacology & physiology 20080801

• Monocrotaline pyrrol is cytotoxic and alters the patterns of GFAP expression on astrocyte primary cultures.

  Toxicology in vitro : an international journal published in association with BIBRA 20080801

• Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice.

  American journal of physiology. Heart and circulatory physiology 20080801

• Total ginsenosides inhibit the right ventricular hypertrophy induced by monocrotaline in rats.

  Biological & pharmaceutical bulletin 20080801

• Reliable experimental model of hepatic veno-occlusive disease caused by monocrotaline.

  Hepatobiliary & pancreatic diseases international : HBPD INT 20080801

• Final report on carcinogens background document for riddelliine.

  Report on carcinogens background document for [substance name] 20080801

• Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension.

  American journal of respiratory and critical care medicine 20080715

• Reduced number and activity of circulating endothelial progenitor cells in patients with idiopathic pulmonary arterial hypertension.

  Respiratory medicine 20080701

• Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone.

  American journal of physiology. Lung cellular and molecular physiology 20080701

• Pyrrolidine dithiocarbamate restores endothelial cell membrane integrity and attenuates monocrotaline-induced pulmonary artery hypertension.

  American journal of physiology. Lung cellular and molecular physiology 20080601

• Down-regulation of MyoD gene expression in rat diaphragm muscle with heart failure.

  International journal of experimental pathology 20080601

• Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine.

  Toxicology letters 20080505

• Skeletal muscle myofibrillar protein oxidation and exercise capacity in heart failure.

  Basic research in cardiology 20080501

• Cilostazol therapy attenuates monocrotaline-induced pulmonary arterial hypertension in rat model.

  Circulation journal : official journal of the Japanese Circulation Society 20080501

• [Contribution of circulating platelet and leukocyte activation to primary pulmonary hypertension in rats].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20080501

• [Quantitative and functional changes of circulating endothelial progenitor cells in dogs with dehydromonocrotaline-induced pulmonary artery hypertension].

  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20080501

• [Expression of connective tissue growth factor and its down-regulation by simvastatin administration in pulmonary hypertensive rats].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20080501

• Role of the TGF-beta/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertension.

  American journal of respiratory and critical care medicine 20080415

• Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080401

• Metabolic activation of retronecine and retronecine N-oxide - formation of DHP-derived DNA adducts.

  Toxicology and industrial health 20080401

• Carnitine-mediated improved response to erythropoietin involves induction of haem oxygenase-1: studies in humans and in an animal model.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080301

• Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition.

  The European respiratory journal 20080301

• Cytoplasmic provenance of STAT3 and PY-STAT3 in the endolysosomal compartments in pulmonary arterial endothelial and smooth muscle cells: implications in pulmonary arterial hypertension.

  American journal of physiology. Lung cellular and molecular physiology 20080301

• Autologous transplantation of bone marrow-derived endothelial progenitor cells attenuates monocrotaline-induced pulmonary arterial hypertension in rats.

  Critical care medicine 20080301

• Pulmonary hypertension associated with COPD.

  International journal of chronic obstructive pulmonary disease 20080301

• Effects of TNF-alpha blockade in monocrotaline-induced pulmonary hypertension.

  Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20080301

• A refined radio-telemetry technique to monitor right ventricle or pulmonary artery pressures in rats: a useful tool in pulmonary hypertension research.

  Pflugers Archiv : European journal of physiology 20080201

• Rosuvastatin provides pleiotropic protection against pulmonary hypertension, right ventricular hypertrophy, and coronary endothelial dysfunction in rats.

  American journal of physiology. Heart and circulatory physiology 20080201

• Smad signaling in the rat model of monocrotaline pulmonary hypertension.

  Toxicologic pathology 20080201

• Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats.

  American journal of respiratory and critical care medicine 20080115

• Single injection of a sustained-release prostacyclin analog improves pulmonary hypertension in rats.

  American journal of respiratory and critical care medicine 20080115

• Effects of erythropoietin on advanced pulmonary vascular remodelling.

  The European respiratory journal 20080101

• Hepatocyte transplantation and drug-induced perturbations in liver cell compartments.

  Hepatology (Baltimore, Md.) 20080101

• Evaluation of olmesartan medoxomil in the rat monocrotaline model of pulmonary hypertension.

  Journal of cardiovascular pharmacology 20080101

• 2-Ethoxyestradiol is antimitogenic and attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling.

  Vascular pharmacology 20080101

• Rho kinase-mediated vasoconstriction in rat models of pulmonary hypertension.

  Methods in enzymology 20080101

• CD45RB is a novel molecular therapeutic target to inhibit Abeta peptide-induced microglial MAPK activation.

  PloS one 20080101

• Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants.

  BMC genomics 20080101

• Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype.

  Genome biology 20080101

• Effects of selective and unselective endothelin-receptor antagonists on prostacyclin synthase gene expression in experimental pulmonary hypertension.

  Scandinavian journal of clinical and laboratory investigation 20080101

• Biomarkers for ragwort poisoning in horses: identification of protein targets.

  BMC veterinary research 20080101

• Gene set enrichment analysis for non-monotone association and multiple experimental categories.

  BMC bioinformatics 20080101

• Use of bioluminescent imaging to assay the transplantation of immortalized human fetal hepatocytes into mice.

  Cell transplantation 20080101

• Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury.

  BMC pulmonary medicine 20080101

• [Comparative characteristics of some pharmacological models of chronic heart failure].

  Eksperimental'naia i klinicheskaia farmakologiia 20080101

• In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors.

  Drug metabolism and disposition: the biological fate of chemicals 20071001

• Dehydromonocrotaline inhibits mitochondrial complex I. A potential mechanism accounting for hepatotoxicity of monocrotaline.

  Toxicon : official journal of the International Society on Toxinology 20071001

• Oral sildenafil prevents and reverses the development of pulmonary hypertension in monocrotaline-treated rats.

  Interactive cardiovascular and thoracic surgery 20071001

• Statin therapy, alone or with rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin study.

  American journal of physiology. Lung cellular and molecular physiology 20071001

• The antiproliferative effect of sildenafil on pulmonary artery smooth muscle cells is mediated via upregulation of mitogen-activated protein kinase phosphatase-1 and degradation of extracellular signal-regulated kinase 1/2 phosphorylation.

  Anesthesia and analgesia 20071001

• A nuclear factor-kappaB inhibitor pyrrolidine dithiocarbamate ameliorates pulmonary hypertension in rats.

  Chest 20071001

• [Effect of triptolide on the expression of matrix metalloproteinases 2 and 9 in lungs of experimental pulmonary hypertension].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20071001

• Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats.

  Circulation research 20070928

• Serotonin transporter protein in pulmonary hypertensive rats treated with atorvastatin.

  American journal of physiology. Lung cellular and molecular physiology 20070901

• Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species.

  Cardiovascular research 20070901

• Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension.

  American journal of physiology. Lung cellular and molecular physiology 20070901

• Preservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in rats.

  American journal of physiology. Heart and circulatory physiology 20070901

• Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats.

  Hypertension (Dallas, Tex. : 1979) 20070901

• Rodent models of PAH: are we there yet?

  American journal of physiology. Lung cellular and molecular physiology 20070901

• Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1.

  PLoS medicine 20070901

• [Effect of triptolide on the development of monocrotaline-induced pulmonary hypertension in pneumonectomized rat].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20070901

• Protective effect of Adhatoda vascia Nees against radiation-induced damage at cellular, biochemical and chromosomal levels in Swiss albino mice.

  Evidence-based complementary and alternative medicine : eCAM 20070901

• Early changes in rat hearts with developing pulmonary arterial hypertension can be detected with three-dimensional electrocardiography.

  American journal of physiology. Heart and circulatory physiology 20070801

• Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats.

  Journal of cardiovascular pharmacology 20070801

• Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium.

  The Journal of physiology 20070715

• Dysfunctional intracellular trafficking in the pathobiology of pulmonary arterial hypertension.

  American journal of respiratory cell and molecular biology 20070701

• Decreased left ventricular function, myocarditis, and coronary arteriolar medial thickening following monocrotaline administration in adult rats.

  Journal of applied physiology (Bethesda, Md. : 1985) 20070701

• Pulmonary arterial hypertension: a disease of tethers, SNAREs and SNAPs?

  American journal of physiology. Heart and circulatory physiology 20070701

• Amlodipine prevents monocrotaline-induced pulmonary arterial hypertension and prolongs survival in rats independent of blood pressure lowering.

  Clinical and experimental pharmacology & physiology 20070701

• Comparison of lung proteome profiles in two rodent models of pulmonary arterial hypertension.

  Proteomics 20070701

• Cardiac sympathetic rejuvenation: a link between nerve function and cardiac hypertrophy.

  Circulation research 20070622

• Impaired NO-mediated vasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats.

  American journal of physiology. Heart and circulatory physiology 20070601

• Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats.

  American journal of physiology. Lung cellular and molecular physiology 20070601

• Monocrotaline pyrrole induces Smad nuclear accumulation and altered signaling expression in human pulmonary arterial endothelial cells.

  Vascular pharmacology 20070601

• Dysfunction of Golgi tethers, SNAREs, and SNAPs in monocrotaline-induced pulmonary hypertension.

  American journal of physiology. Lung cellular and molecular physiology 20070601

• The transforming growth factor-beta/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension.

  The European respiratory journal 20070601

• [Changes of pulmonary artery protein kinase C activity in rats with chronic inflammatory pulmonary hypertension].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070601

• [Effect of simvastatin on rat pulmonary hypertension induced by high pulmonary blood flow and injected monocrotaline].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20070601

• Inhibitory effect of ginsenoside Rb1 on cardiac hypertrophy induced by monocrotaline in rat.

  Journal of ethnopharmacology 20070522

• Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension.

  Arteriosclerosis, thrombosis, and vascular biology 20070501

• [Expression and activity of RhoA/Rho kinase in remodeling of high blood flow pulmonary vessels.].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20070501

• Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension.

  American journal of physiology. Lung cellular and molecular physiology 20070401

• Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling.

  American journal of physiology. Lung cellular and molecular physiology 20070401

• Recent progress in the treatment of pulmonary arterial hypertension: expectation for rho-kinase inhibitors.

  The Tohoku journal of experimental medicine 20070401

• [Animal models of pulmonary arterial hypertension].

  Revue des maladies respiratoires 20070401

• [Changes of thrombomodulin in rats with pulmonary hypertension induced by monocrotaline].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20070401

• Aberrant cytoplasmic sequestration of eNOS in endothelial cells after monocrotaline, hypoxia, and senescence: live-cell caveolar and cytoplasmic NO imaging.

  American journal of physiology. Heart and circulatory physiology 20070301

• Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension.

  The European respiratory journal 20070301

• Internalization and dephosphorylation of connexin43 in hypertrophied right ventricles of rats with pulmonary hypertension.

  Circulation journal : official journal of the Japanese Circulation Society 20070301

• Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration.

  Gastroenterology 20070301

• [Pulmonary hypertension treatment: future prospects].

  Archivos de bronconeumologia 20070301

• Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction.

  American journal of physiology. Heart and circulatory physiology 20070201

• Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats.

  Journal of cardiovascular pharmacology 20070201

• Diverse contribution of bone marrow-derived cells to vascular remodeling associated with pulmonary arterial hypertension and arterial neointimal formation.

  Circulation 20070130

• Inhibition of rho kinase attenuates high flow induced pulmonary hypertension in rats.

  Chinese medical journal 20070105

• Right ventricular hypertrophy causes impairment of left ventricular diastolic function in the rat.

  Basic research in cardiology 20070101

• Propofol increases pulmonary vascular resistance during alpha-adrenoreceptor activation in normal and monocrotaline-induced pulmonary hypertensive rats.

  Anesthesia and analgesia 20070101

• Granulocyte colony-stimulating factor prevents progression of monocrotaline-induced pulmonary arterial hypertension in rats.

  Circulation journal : official journal of the Japanese Circulation Society 20070101

• Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice.

  Respiratory research 20070101

• Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice.

  Respiratory research 20070101

• Activity of endothelium-derived hyperpolarizing factor is augmented in monocrotaline-induced pulmonary hypertension of rat lungs.

  Journal of vascular research 20070101

• Effects on cytokines and histology by treatment with the ACE inhibitor captopril and the antioxidant retinoic acid in the monocrotaline model of experimentally induced lung fibrosis.

  Current pharmaceutical design 20070101

• The role of peroxisome proliferator-activated receptors in pulmonary vascular disease.

  PPAR research 20070101

• Characterisation of a rat model of pulmonary arterial hypertension.

  Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20070101

• PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice.

  BMC cell biology 20070101

• Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension.

  Pathology, research and practice 20070101

• Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver.

  BMC bioinformatics 20070101

• Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats.

  BMC bioinformatics 20070101

• [Chronic administration of serotonin transporter inhibitor (fluoxetine) decreases monocrotaline-induced pulmonary hypertension in rats].

  Eksperimental'naia i klinicheskaia farmakologiia 20070101

• [Chronic blockade of serotonin transporter promotes restoration of the sensitivity of pulmonary vessels to vasoconstrictive agents in rats with monocrotaline-induced pulmonary hypertension].

  Eksperimental'naia i klinicheskaia farmakologiia 20070101

• Modeling inflammation-drug interactions in vitro: a rat Kupffer cell-hepatocyte coculture system.

  Toxicology in vitro : an international journal published in association with BIBRA 20061201

• 2-Methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertension.

  Vascular pharmacology 20061201

• Sleeping Beauty-mediated eNOS gene therapy attenuates monocrotaline-induced pulmonary hypertension in rats.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20061201

• The protective effect of HMG-CoA reductase inhibitors against monocrotaline-induced pulmonary hypertension in the rat might not be a class effect: comparison of pravastatin and atorvastatin.

  Naunyn-Schmiedeberg's archives of pharmacology 20061201

• Monocrotaline promotes transplanted cell engraftment and advances liver repopulation in rats via liver conditioning.

  Hepatology (Baltimore, Md.) 20061201

• Heart failure alters matrix metalloproteinase gene expression and activity in rat skeletal muscle.

  International journal of experimental pathology 20061201

• Sildenafil in the treatment of pulmonary hypertension.

  Vascular health and risk management 20061201

• Prostacyclin therapy increases right ventricular capillarisation in a model for flow-associated pulmonary hypertension.

  European journal of pharmacology 20061107

• Allicin in garlic protects against coronary endothelial dysfunction and right heart hypertrophy in pulmonary hypertensive rats.

  American journal of physiology. Heart and circulatory physiology 20061101

• Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat.

  American journal of physiology. Heart and circulatory physiology 20061101

• Sertraline protects against monocrotaline-induced pulmonary hypertension in rats.

  Clinical and experimental pharmacology & physiology 20061101

• Protective role of protein C inhibitor in monocrotaline-induced pulmonary hypertension.

  Journal of thrombosis and haemostasis : JTH 20061101

• Treprostinil in advanced experimental pulmonary hypertension: beneficial outcome without reversed pulmonary vascular remodeling.

  Journal of cardiovascular pharmacology 20061101

• [Expression of GATA6 gene in lung tissue of rat with pulmonary hypertension].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20061101

• Mycophenolate mofetil attenuates pulmonary arterial hypertension in rats.

  Biochemical and biophysical research communications 20061020

• ROCK controls matrix synthesis in vascular smooth muscle cells: coupling vasoconstriction to vascular remodeling.

  Circulation research 20061013

• Myocardial dysfunction and neurohumoral activation without remodeling in left ventricle of monocrotaline-induced pulmonary hypertensive rats.

  American journal of physiology. Heart and circulatory physiology 20061001

• Major components in the hairpencil secretion of a butterfly, Euploea mulciber (Lepidoptera, Danaidae): their origins and male behavioral responses to pyrrolizidine alkaloids.

  Journal of insect physiology 20061001

• Sequence of echocardiographic changes during development of right ventricular failure in rat.

  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20061001

• Reduced inotropic effect of nifekalant in failing hearts in rats.

  The Journal of pharmacology and experimental therapeutics 20060901

• The HMG-CoA reductase inhibitor, pravastatin, prevents the development of monocrotaline-induced pulmonary hypertension in the rat through reduction of endothelial cell apoptosis and overexpression of eNOS.

  Naunyn-Schmiedeberg's archives of pharmacology 20060901

• How valid are animal models to evaluate treatments for pulmonary hypertension?

  Naunyn-Schmiedeberg's archives of pharmacology 20060901

• Upregulated neurohumoral factors are associated with left ventricular remodeling and poor prognosis in rats with monocrotaline-induced pulmonary arterial hypertension.

  Circulation journal : official journal of the Japanese Circulation Society 20060901

• Short-term administration of a cell-permeable caveolin-1 peptide prevents the development of monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy.

  Circulation 20060829

• Anticoagulation and inhibition of nitric oxide synthase influence hepatic hypoxia after monocrotaline exposure.

  Toxicology 20060815

• Microvascular regeneration in established pulmonary hypertension by angiogenic gene transfer.

  American journal of respiratory cell and molecular biology 20060801

• Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension.

  Circulation 20060704

• Inotropic and lusitropic effects of ghrelin and their modulation by the endocardial endothelium, NO, prostaglandins, GHS-R1a and KCa channels.

  Peptides 20060701

• Role of chymase-dependent angiotensin II formation in monocrotaline-induced pulmonary hypertensive rats.

  Pediatric research 20060701

• Myocyte morphological characteristics differ between the phases of pulmonary hypertension-induced ventricular hypertrophy and failure.

  International heart journal 20060701

• Remodeling excitation-contraction coupling of hypertrophied ventricular myocytes is dependent on T-type calcium channels expression.

  Biochemical and biophysical research communications 20060630

• Discordant regulatory changes in monocrotaline-induced megalocytosis of lung arterial endothelial and alveolar epithelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20060601

• Bosentan, sildenafil, and their combination in the monocrotaline model of pulmonary hypertension in rats.

  Experimental biology and medicine (Maywood, N.J.) 20060601

• Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension.

  Circulation research 20060526

• Upregulation of profilin, cofilin-2 and LIMK2 in cultured pulmonary artery smooth muscle cells and in pulmonary arteries of monocrotaline-treated rats.

  Vascular pharmacology 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Monocrotaline pyrrole-induced megalocytosis of lung and breast epithelial cells: Disruption of plasma membrane and Golgi dynamics and an enhanced unfolded protein response.

  Toxicology and applied pharmacology 20060315

• [The change of mast cells and macrophages in the lung of rat with pulmonary hypertension].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060301

• Selective right, but not left, coronary endothelial dysfunction precedes development of pulmonary hypertension and right heart hypertrophy in rats.

  American journal of physiology. Heart and circulatory physiology 20060201

• Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling.

  Circulation 20060117

• Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine.

  Cancer letters 20060108

• Heme oxygenase-1 mediates the protective effects of rapamycin in monocrotaline-induced pulmonary hypertension.

  Laboratory investigation; a journal of technical methods and pathology 20060101

• Phosphodiesterase type 4 expression and anti-proliferative effects in human pulmonary artery smooth muscle cells.

  Respiratory research 20060101

• Genistein, a phytoestrogen, attenuates monocrotaline-induced pulmonary hypertension.

  Respiration; international review of thoracic diseases 20060101

• Ghrelin reverses molecular, structural and hemodynamic alterations of the right ventricle in pulmonary hypertension.

  Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20060101

• Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale).

  BMC bioinformatics 20060101

• Hypoxia and dehydroepiandrosterone in old age: a mouse survival study.

  Respiratory research 20060101

• Cardiac hypertrophy induced by prostaglandin F(2alpha) may be mediated by calcineurin signal transduction pathway in rats.

  Sheng li xue bao : [Acta physiologica Sinica] 20051225

• A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension.

  American journal of respiratory and critical care medicine 20051215

• Doppler tissue imaging in assessment of pulmonary hypertension-induced right ventricle dysfunction.

  American journal of physiology. Heart and circulatory physiology 20051201

• Monocrotaline pyrrole targets proteins with and without cysteine residues in the cytosol and membranes of human pulmonary artery endothelial cells.

  Proteomics 20051101

• CPU 86017, p-chlorobenzyltetrahydroberberine chloride, attenuates monocrotaline-induced pulmonary hypertension by suppressing endothelin pathway.

  Acta pharmacologica Sinica 20051101

• Estradiol metabolites attenuate monocrotaline-induced pulmonary hypertension in rats.

  Journal of cardiovascular pharmacology 20051001

• Effects of nicorandil on monocrotaline-induced pulmonary arterial hypertension in rats.

  Journal of cardiovascular pharmacology 20051001

• Contractile effects of Ghrelin and expression of its receptor GHS-R1a in normal and hypertrophic myocardium.

  Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20051001

• Excess l-arginine restores endothelium-dependent relaxation impaired by monocrotaline pyrrole.

  Toxicology and applied pharmacology 20050915

• Mechanical stress-dependent transcriptional regulation of sarcolipin gene in the rodent atrium.

  Biochemical and biophysical research communications 20050902

• The role of increased pulmonary blood flow in pulmonary arterial hypertension.

  The European respiratory journal 20050901

• Metabolic activation of the tumorigenic pyrrolizidine alkaloid, monocrotaline, leading to DNA adduct formation in vivo.

  Cancer letters 20050808

• Inhaled iloprost reverses vascular remodeling in chronic experimental pulmonary hypertension.

  American journal of respiratory and critical care medicine 20050801

• [The effect of compound macrostem onion capsule on metabolism of arachidonic acid in a rat model of monocrotaline-induced pulmonary artery hypertension].

  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20050801

• Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension.

  Circulation 20050719

• Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050701

• Immunohistochemical determination of cytosolic cytochrome C concentration in cardiomyocytes.

  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20050701

• Development of occlusive neointimal lesions in distal pulmonary arteries of endothelin B receptor-deficient rats: a new model of severe pulmonary arterial hypertension.

  Circulation 20050607

• Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats.

  Circulation 20050531

• Microarray analysis reveals pivotal divergent mRNA expression profiles early in the development of either compensated ventricular hypertrophy or heart failure.

  Physiological genomics 20050511

• ClC-3 chloride channel is upregulated by hypertrophy and inflammation in rat and canine pulmonary artery.

  British journal of pharmacology 20050501

• Skeletal muscle myofibrillar protein oxidation in heart failure and the protective effect of Carvedilol.

  Journal of molecular and cellular cardiology 20050501

• Macro- and micropulmonary hemodynamic changes to nitric oxide blockade in monocrotaline-induced pulmonary hypertension in rats--an in vivo approach.

  Journal of the Formosan Medical Association = Taiwan yi zhi 20050501

• [Effects of peroxisome proliferator-activated receptor gamma ligands on monocrotaline-induced pulmonary hypertension in rats].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20050501

• Metabolic activation of the tumorigenic pyrrolizidine alkaloid, retrorsine, leading to DNA adduct formation in vivo.

  International journal of environmental research and public health 20050501

• Monocrotaline pyrrole-induced endothelial cell megalocytosis involves a Golgi blockade mechanism.

  American journal of physiology. Cell physiology 20050401

• Pressure overload and neurohumoral activation differentially affect the myocardial proteome.

  Proteomics 20050401

• Decreased vagal control over heart rate in rats with right-sided congestive heart failure: downregulation of neuronal nitric oxide synthase.

  Circulation journal : official journal of the Japanese Circulation Society 20050401

• Animal models of heart failure: what is new?

  The Annals of thoracic surgery 20050401

• Simvastatin treatment of pulmonary hypertension: an observational case series.

  Chest 20050401

• Do naïve ruminants degrade alkaloids in the rumen?

  Journal of chemical ecology 20050401

• Differential utilization of pyrrolizidine alkaloids by males of a danaid butterfly, Parantica sita, for the production of danaidone in the alar scent organ.

  Journal of chemical ecology 20050401

• Increased pulmonary heme oxygenase-1 and delta-aminolevulinate synthase expression in monocrotaline-induced pulmonary hypertension.

  Current neurovascular research 20050401

• Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid.

  Toxicology letters 20050315

• Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease.

  Circulation research 20050304

• Acute intoxication by Crotalaria retusa in sheep.

  Toxicon : official journal of the International Society on Toxinology 20050301

• Monocrotaline-induced pulmonary hypertension correlates with upregulation of connective tissue growth factor expression in the lung.

  Experimental & molecular medicine 20050227

• Gene transfer of a TIE2 receptor antagonist prevents pulmonary hypertension in rodents.

  The Journal of thoracic and cardiovascular surgery 20050201

• [Decrease of nitric oxide (NO)-cGMP-dependent vasodilatation in the vessels of lesser circulation in endothelial dysfunction].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20050201

• Monocrotaline, an alternative to retrorsine-based hepatocyte transplantation in rodents.

  Cell transplantation 20050101

• PKC translocation and ERK1/2 activation in compensated right ventricular hypertrophy secondary to chronic emphysema.

  BMC physiology 20050101

• [Effect of chronic administration of aminoguanidine on vascular reactivity of the greater circulation in rats with monocrotaline-induced pulmonary hypertension].

  Izvestiia Akademii nauk. Seriia biologicheskaia 20050101

• Attenuated noradrenaline-induced contraction of pulmonary arteries from rats treated with monocrotaline: role of rho kinase.

  Journal of vascular research 20050101

• Influence of hypoxia on the domiciliation of mesenchymal stem cells after infusion into rats: possibilities of targeting pulmonary artery remodeling via cells therapies?

  Respiratory research 20050101

• Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration.

  Respiratory research 20050101

• If you've got it, flaunt it: ingested alkaloids affect corematal display behavior in the salt marsh moth, Estigmene acrea.

  Journal of insect science (Online) 20050101

• Chloride channels and alpha1-adrenoceptor-mediated pulmonary artery smooth muscle contraction: effect of pulmonary hypertension.

  European journal of pharmacology 20041215

• DNA cross-linking by dehydromonocrotaline lacks apparent base sequence preference.

  Toxicological sciences : an official journal of the Society of Toxicology 20041201

• Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension.

  American journal of physiology. Heart and circulatory physiology 20041201

• C-type natriuretic peptide ameliorates monocrotaline-induced pulmonary hypertension in rats.

  American journal of respiratory and critical care medicine 20041201

• Gene transfer of hepatocyte growth factor with prostacyclin synthase in severe pulmonary hypertension of rats.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20041201

• Specific inhibition of p38 mitogen-activated protein kinase with FR167653 attenuates vascular proliferation in monocrotaline-induced pulmonary hypertension in rats.

  The Journal of thoracic and cardiovascular surgery 20041201

• Repeated gene transfer of naked prostacyclin synthase plasmid into skeletal muscles attenuates monocrotaline-induced pulmonary hypertension and prolongs survival in rats.

  Human gene therapy 20041201

• Hepatocyte growth factor suppresses vascular medial hyperplasia and matrix accumulation in advanced pulmonary hypertension of rats.

  Circulation 20041102

• Comparison of hepatic in vitro metabolism of the pyrrolizidine alkaloid senecionine in sheep and cattle.

  American journal of veterinary research 20041101

• YM598, an orally active ET(A) receptor antagonist, ameliorates the progression of cardiopulmonary changes and both-side heart failure in rats with cor pulmonale and myocardial infarction.

  Journal of cardiovascular pharmacology 20041101

• Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis.

  Circulation research 20041015

• Disruption of endothelial-cell caveolin-1alpha/raft scaffolding during development of monocrotaline-induced pulmonary hypertension.

  Circulation 20040914

• The orally active nonpeptide selective endothelin ETA receptor antagonist YM598 prevents and reverses the development of pulmonary hypertension in monocrotaline-treated rats.

  European journal of pharmacology 20040802

• Role of endothelin ETB receptor in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats.

  European journal of pharmacology 20040802

• Roles of endothelin ETA and ETB receptors in the pathogenesis of monocrotaline-induced pulmonary hypertension.

  Journal of cardiovascular pharmacology 20040801

• [Effect of chronic administration of aminoguanidine on the reactivity of pulmonary vessels in rats with monocrotaline-induced pulmonary hypertension].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20040701

• Emission-particle-induced ventilatory abnormalities in a rat model of pulmonary hypertension.

  Environmental health perspectives 20040601

• Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats.

  American journal of physiology. Heart and circulatory physiology 20040501

• [Effect of elastase inhibitor on pulmonary hypertension induced by monocrotaline].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20040501

• Antioxidant and oxidative stress changes in experimental cor pulmonale.

  Molecular and cellular biochemistry 20040501

• Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension.

  Circulation research 20040430

• Longitudinal transcriptional analysis of developing neointimal vascular occlusion and pulmonary hypertension in rats.

  Physiological genomics 20040413

• Cell therapy for pulmonary hypertension: what is the true potential of endothelial progenitor cells?

  Circulation 20040330

• Contractile reserve but not tension is reduced in monocrotaline-induced right ventricular hypertrophy.

  American journal of physiology. Heart and circulatory physiology 20040301

• Nitric oxide formation and plasma L-arginine levels in pulmonary hypertensive rats.

  Respiratory medicine 20040301

• Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.

  Circulation research 20040220

• Right ventricle-sparing heart transplantation effective against iatrogenic pulmonary hypertension.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20040201

• Downregulation of Kv4.2 and Kv4.3 channel gene expression in right ventricular hypertrophy induced by monocrotaline in rat.

  Acta pharmacologica Sinica 20040201

• Acquired and partially de novo synthesized pyrrolizidine alkaloids in two polyphagous arctiids and the alkaloid profiles of their larval food-plants.

  Journal of chemical ecology 20040201

• Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats.

  American journal of respiratory and critical care medicine 20040101

• Beneficial effects of GH/IGF-1 on skeletal muscle atrophy and function in experimental heart failure.

  American journal of physiology. Cell physiology 20040101

• A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats.

  American journal of respiratory and critical care medicine 20040101

• Effect of nolomirole on monocrotaline-induced heart failure.

  Pharmacological research 20040101

• Modes of cell death in rat liver after monocrotaline exposure.

  Toxicological sciences : an official journal of the Society of Toxicology 20040101

• Effect of endothelin antagonism on contractility, intracellular calcium regulation and calcium regulatory protein expression in right ventricular hypertrophy of the rat.

  Basic & clinical pharmacology & toxicology 20040101

• Chronic hypoxia- and monocrotaline-induced elevation of hypoxia-inducible factor-1 alpha levels and pulmonary hypertension.

  Journal of biomedical science 20040101

• Comparison of strength properties of normotensive and hypertensive rat pulmonary arteries.

  Biomedical sciences instrumentation 20040101

• Transplantation of endothelial progenitor cells into the lung to alleviate pulmonary hypertension in dogs.

  Tissue engineering 20040101

• JTV-506, a new K(ATP) channel opener, relaxes pulmonary artery isolated from monocrotaline-treated pulmonary hypertensive rats.

  Journal of anesthesia 20040101

• Alpha 1-adrenoceptor subtypes mediating noradrenaline-induced contraction of pulmonary artery from pulmonary hypertensive rats.

  European journal of pharmacology 20031215

• Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliine.

  Toxicology letters 20031210

• Activation of the right ventricular endothelin (ET) system in the monocrotaline model of pulmonary hypertension: response to chronic ETA receptor blockade.

  Clinical science (London, England : 1979) 20031201

• Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats.

  Cardiovascular research 20031201

• [Involvement of tetrahydrobiopterin in local change of endothelium-dependent vasorelaxation in pulmonary hypertension].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20031201

• Basement membrane and matrix metalloproteinases in monocrotaline-induced liver injury.

  Toxicological sciences : an official journal of the Society of Toxicology 20031101

• Augmented pulmonary vascular and venous constrictions to N(G)-nitro-L-arginine methyl ester in rats with monocrotaline-induced pulmonary hypertension.

  Pharmacology 20031101

• Rhythmical contractions in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats.

  Pflugers Archiv : European journal of physiology 20031101

• Experience influences gustatory responsiveness to pyrrolizidine alkaloids in the polyphagous caterpillar, Estigmene acrea.

  Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20031101

• Repeated inhalation of adrenomedullin ameliorates pulmonary hypertension and survival in monocrotaline rats.

  American journal of physiology. Heart and circulatory physiology 20031101

• Are insect-synthesized retronecine esters (creatonotines) the precursors of the male courtship pheromone in the arctiid moth Estigmene acrea?

  Journal of chemical ecology 20031101

• Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome.

  Hepatology (Baltimore, Md.) 20031001

• Estrogen and enalapril attenuate the development of right ventricular hypertrophy induced by monocrotaline in ovariectomized rats.

  Journal of Korean medical science 20031001

• Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells.

  Circulation 20030930

• Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition.

  Gastroenterology 20030901

• Identification of DNA adducts derived from riddelliine, a carcinogenic pyrrolizidine alkaloid.

  Chemical research in toxicology 20030901

• Liver inflammation during monocrotaline hepatotoxicity.

  Toxicology 20030828

• Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells.

  Circulation 20030819

• Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat.

  Circulation research 20030808

• Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy.

  Toxicological sciences : an official journal of the Society of Toxicology 20030801

• The coagulation system contributes to synergistic liver injury from exposure to monocrotaline and bacterial lipopolysaccharide.

  Toxicological sciences : an official journal of the Society of Toxicology 20030801

• DA-8159, a potent cGMP phosphodiesterase inhibitor, attenuates monocrotaline-induced pulmonary hypertension in rats.

  Archives of pharmacal research 20030801

• Endothelial cell injury and coagulation system activation during synergistic hepatotoxicity from monocrotaline and bacterial lipopolysaccharide coexposure.

  Toxicological sciences : an official journal of the Society of Toxicology 20030701

• Taste receptors for pyrrolizidine alkaloids in a monophagous caterpillar.

  Journal of chemical ecology 20030701

• Progressive development of pulmonary hypertension leading to right ventricular hypertrophy assessed by echocardiography in rats.

  Experimental animals 20030701

• Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer limits monocrotaline-induced pulmonary vascular remodeling in rats.

  Human gene therapy 20030610

• Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome.

  American journal of physiology. Gastrointestinal and liver physiology 20030601

• Pyrrolizidine alkaloids as oviposition stimulants for the cinnabar moth, Tyria jacobaeae.

  Journal of chemical ecology 20030601

• Protective role of angiopoietin-1 in experimental pulmonary hypertension.

  Circulation research 20030516

• Granulocyte colony-stimulating factor enhances alpha-naphthylthiourea-induced pulmonary hypertension.

  Journal of applied physiology (Bethesda, Md. : 1985) 20030501

• Effect of a surgical aortocaval fistula on monocrotaline-induced pulmonary hypertension.

  Critical care medicine 20030401

• Tachykinin dysfunction attenuates monocrotaline-induced pulmonary hypertension.

  Toxicology and applied pharmacology 20030315

• Effects of monocrotaline pyrrole and thrombin on pulmonary endothelial cell junction and matrix adhesion proteins.

  Toxicology 20030303

• Role of neutrophils in the synergistic liver injury from monocrotaline and bacterial lipopolysaccharide exposure.

  Toxicological sciences : an official journal of the Society of Toxicology 20030301

• Cardiac beta-adrenoceptor changes in monocrotaline-treated rats: differences between membrane preparations from whole ventricles and isolated ventricular cardiomyocytes.

  Journal of cardiovascular pharmacology 20030301

• Skeletal muscle abnormalities in rats with experimentally induced heart hypertrophy and failure.

  Basic research in cardiology 20030301

• Final height outcome and value of height prediction in boys with constitutional delay in growth and adolescence treated with intramuscular testosterone 125 mg per month for 3 months.

  Clinical endocrinology 20030301

• The role of Kupffer cells and TNF-alpha in monocrotaline and bacterial lipopolysaccharide-induced liver injury.

  Toxicological sciences : an official journal of the Society of Toxicology 20030101

• Cytostatic properties of some angiotensin I converting enzyme inhibitors and of angiotensin II type I receptor antagonists.

  Current pharmaceutical design 20030101

• The activation pattern of the antioxidant enzymes in the right ventricle of rat in response to pressure overload is of heart failure type.

  Heart disease (Hagerstown, Md.) 20030101

• Gender differences in pulmonary arterial reactivity to dilatory agonists in pulmonary hypertension.

  The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 20030101

• DA-8159, a new PDE5 inhibitor, attenuates the development of compensatory right ventricular hypertrophy in a rat model of pulmonary hypertension.

  The Journal of international medical research 20030101

• Dietary alkaloids and the development of androconial organs in Estigmene acrea.

  Journal of insect science (Online) 20030101

• Pulmonary effects of ultrafine and fine ammonium salts aerosols in healthy and monocrotaline-treated rats following short-term exposure.

  Inhalation toxicology 20021201

• Pyrrolizidine alkaloid clivorine inhibits human normal liver L-02 cells growth and activates p38 mitogen-activated protein kinase in L-02 cells.

  Toxicon : official journal of the International Society on Toxinology 20021201

• Ventricular hypertrophy plus neurohumoral activation is necessary to alter the cardiac beta-adrenoceptor system in experimental heart failure.

  Circulation research 20021129

• Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats.

  American journal of respiratory and critical care medicine 20021115

• Dexfenfluramine protects against pulmonary hypertension in rats.

  Journal of applied physiology (Bethesda, Md. : 1985) 20021101

• Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary hypertension in rats.

  American journal of physiology. Heart and circulatory physiology 20021101

• Acute and chronic effects of T-1032, a novel selective phosphodiesterase type 5 inhibitor, on monocrotaline-induced pulmonary hypertension in rats.

  Biological & pharmaceutical bulletin 20021101

• Cardiac and thermoregulatory effects of instilled particulate matter-associated transition metals in healthy and cardiopulmonary-compromised rats.

  Journal of toxicology and environmental health. Part A 20021025

• L-Carnitine: a potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in heart failure.

  American journal of physiology. Cell physiology 20020901

• Calibrated histochemistry applied to oxygen supply and demand in hypertrophied rat myocardium.

  Microscopy research and technique 20020901

• Pyrrolizidine alkaloids from Senecio jacobaea affect fungal growth.

  Journal of chemical ecology 20020901

• Cardiac modulations of ANG II receptor expression in rats with hypoxic pulmonary hypertension.

  American journal of physiology. Heart and circulatory physiology 20020801

• Effect of thalidomide on the skeletal muscle in experimental heart failure.

  European journal of heart failure 20020801

• Heme oxygenase-1 reduces murine monocrotaline-induced pulmonary inflammatory responses and resultant right ventricular overload.

  Antioxidants & redox signaling 20020801

• Reduction of monocrotaline-induced hepatic injury by deleted variant of hepatocyte growth factor (dHGF) in rats.

  Liver 20020801

• [The effect and mechanism of felodipine on monocrotaline induced pulmonary hypertension in rats].

  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20020801

• The temporal relationship between bacterial lipopolysaccharide and monocrotaline exposures influences toxicity: shift in response from hepatotoxicity to nitric oxide-dependent lethality.

  Journal of toxicology and environmental health. Part A 20020726

• Serial noninvasive assessment of progressive pulmonary hypertension in a rat model.

  American journal of physiology. Heart and circulatory physiology 20020701

• Effects of diesel exhaust enriched concentrated PM2.5 in ozone preexposed or monocrotaline-treated rats.

  Inhalation toxicology 20020701

• Dietary fish oil protects against lung and liver inflammation and fibrosis in monocrotaline treated rats.

  Toxicology 20020614

• Suppressive effect of pulmonary hypertension and leukocyte activation by inhaled prostaglandin E1 in rats with monocrotaline-induced pulmonary hypertension.

  Experimental lung research 20020601

• Attenuation of negatively regulated ANP secretion by calcium in hypertrophied atria.

  Regulatory peptides 20020530

• Anticoagulants prevent monocrotaline-induced hepatic parenchymal cell injury but not endothelial cell injury in the rat.

  Toxicology and applied pharmacology 20020501

• Stage-dependent activation of cell cycle and apoptosis mechanisms in the right ventricle by pressure overload.

  Biochimica et biophysica acta 20020424

• The effects of vasoactive intestinal peptide on monocrotaline induced pulmonary hypertensive rabbits following cardiopulmonary bypass: a comparative study with isoproteronol and nitroglycerine.

  Cardiovascular surgery (London, England) 20020401

• Temporal modulation of pyrrolizidine alkaloid intake and genetic variation in performance of Utetheisa ornatrix caterpillars.

  Journal of chemical ecology 20020401

• Therapeutic effects of DCDDP, a calcium channel blocker, on chronic pulmonary hypertension in rat.

  Journal of applied physiology (Bethesda, Md. : 1985) 20020301

• Defective intracellular calcium handling in monocrotaline-induced right ventricular hypertrophy: protective effect of long-term endothelin-A receptor blockade with 2-benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy-phenyl-)- 4-oxobut-2-enoate-sodium (PD 155080).

  The Journal of pharmacology and experimental therapeutics 20020201

• Endothelial cell injury and fibrin deposition in rat liver after monocrotaline exposure.

  Toxicological sciences : an official journal of the Society of Toxicology 20020201

• Changes in alpha(1)-adrenergic vascular reactivity in monocrotaline-treated rats.

  Naunyn-Schmiedeberg's archives of pharmacology 20020201

• Changes of sequestered leukocytes and platelets by inhalation prostaglandin E(1) in the pulmonary microvasculature of rats with monocrotaline-induced pulmonary hypertension.

  Journal of vascular research 20020101

• Effects of monocrotaline on endothelial nitric oxide synthase expression and sulfhydryl levels in rat lungs.

  Heart disease (Hagerstown, Md.) 20020101

• Myocardial force development and structural changes associated with monocrotaline induced cardiac hypertrophy and heart failure.

  Journal of muscle research and cell motility 20020101

• Attenuation of inhibitory effect of CNP on the secretion of ANP from hypertrophied atria.

  American journal of physiology. Regulatory, integrative and comparative physiology 20011101

• Gelatinase expression in pulmonary arteries during experimental pulmonary hypertension.

  The European respiratory journal 20011101

• Gemtuzumab Ozogamicin (Mylotarg) and hepatic veno-occlusive disease: take two acetaminophen, and..

  Bone marrow transplantation 20011101

• Cell-based gene transfer of vascular endothelial growth factor attenuates monocrotaline-induced pulmonary hypertension.

  Circulation 20011030

• Accentuation of ANP secretion to endothelin-1 in hypertrophied atria.

  Regulatory peptides 20011015

• Decrease in the Ca2+-activated K+ current of pulmonary arterial smooth muscle in pulmonary hypertension rats.

  Naunyn-Schmiedeberg's archives of pharmacology 20010901

• Time- and subunit-dependent differential mRNA expression of L-type Ca2+ channel during progression of right ventricular hypertrophy.

  Japanese heart journal 20010901

• Angiotensin-converting enzyme inhibitor preserves p21 and endothelial nitric oxide synthase expression in monocrotaline-induced pulmonary arterial hypertension in rats.

  Circulation 20010821

• Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles.

  Toxicology and applied pharmacology 20010815

• Attenuation of compensatory right ventricular hypertrophy and heart failure following monocrotaline-induced pulmonary vascular injury by the Na+-H+ exchange inhibitor cariporide.

  The Journal of pharmacology and experimental therapeutics 20010801

• Restoration of calcium handling properties of adult cardiac myocytes from hypertrophied hearts.

  Cell calcium 20010701

• Lack of protective action of cysteine against the fetotoxic effect of monocrotaline.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010701

• Contribution of chloride channel activation to the elevated muscular tone of the pulmonary artery in monocrotaline-induced pulmonary hypertensive rats.

  Japanese journal of pharmacology 20010701

• [Monocrotaline-induced pulmonary hypertension in animals].

  Nihon rinsho. Japanese journal of clinical medicine 20010601

• [Drug induced pulmonary hypertension].

  Nihon rinsho. Japanese journal of clinical medicine 20010601

• Beneficial effects on skeletal muscle of the angiotensin II type 1 receptor blocker irbesartan in experimental heart failure.

  Circulation 20010501

• All-trans retinoic acid in pulmonary vascular structural remodeling in rats with pulmonary hypertension induced by monocrotaline.

  Chinese medical journal 20010501

• Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity.

  Toxicology letters 20010331

• Reactive oxygen species and substance P in monocrotaline-induced pulmonary hypertension.

  Toxicology and applied pharmacology 20010315

• Enhanced gene expression of renin-angiotensin system, TGF-beta1, endothelin-1 and nitric oxide synthase in right-ventricular hypertrophy.

  Pharmacological research 20010301

• Apoptosis and changes in contractile protein pattern in the skeletal muscle in heart failure.

  Acta physiologica Scandinavica 20010301

• 5-HT1B receptor augmented 5-HT vasoconstrictor response of pulmonary artery in monocrotaline-induced pulmonary hypertensive rats.

  Acta pharmacologica Sinica 20010301

• Hemodynamic unloading leads to regression of pulmonary vascular disease in rats.

  The Journal of thoracic and cardiovascular surgery 20010201

• 40-O-(2-hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertension and neointimal formation in rats.

  American journal of respiratory and critical care medicine 20010201

• Effectiveness of a nonselective ET(A/B) and a selective ET(A) antagonist in rats with monocrotaline-induced pulmonary hypertension.

  Circulation 20010116

• Development of a (32)P-postlabeling/HPLC method for detection of dehydroretronecine-derived DNA adducts in vivo and in vitro.

  Chemical research in toxicology 20010101

• Metabolic activation of the tumorigenic pyrrolizidine alkaloid, riddelliine, leading to DNA adduct formation in vivo.

  Chemical research in toxicology 20010101

• Vascular remodeling in experimentally induced subacute canine pulmonary hypertension.

  Experimental lung research 20010101

• Micronucleus formation in human lymphocytes and in the metabolically competent human hepatoma cell line Hep-G2: results with 15 naturally occurring substances.

  Anticancer research 20010101

• [Monocrotaline induce pulmonary hypertension in animal models].

  Pneumologia (Bucharest, Romania) 20010101

• Role of endothelin-1 in lung disease.

  Respiratory research 20010101

• Genomic approaches to research in pulmonary hypertension.

  Respiratory research 20010101

• Molecular mechanisms of cardiac hypertrophy induced by toxicants.

  Cardiovascular toxicology 20010101

• Polyamine regulatory processes and oxidative stress in monocrotaline-treated pulmonary artery endothelial cells.

  Cell biology international 19971201

• Oxidative stress mediates monocrotaline-induced alterations in tenascin expression in pulmonary artery endothelial cells.

  The international journal of biochemistry & cell biology 19970501

• Effect of losartan on right ventricular hypertrophy and cardiac angiotensin I-converting enzyme activity in pulmonary hypertensive rats.

  Clinical and experimental hypertension (New York, N.Y. : 1993) 19960101

• Pinacidil-induced relaxation in pulmonary arteries isolated from pulmonary hypertensive and normotensive rats and pre-contracted with different spasmogens.

  Pulmonary pharmacology 19941201

• COR pulmonale is caused by monocrotaline and dehydromonocrotaline, but not by glutathione or cysteine conjugates of dihydropyrrolizine.

  Toxicology and applied pharmacology 19930101

• Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

  Journal of natural products 19910101