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Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells.
Toxicology 20180701
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Editor's Highlight: PPARβ/δ and PPARγ Inhibit Melanoma Tumorigenicity by Modulating Inflammation and Apoptosis.
Toxicological sciences : an official journal of the Society of Toxicology 20171001
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Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy.
The Journal of biological chemistry 20161125
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Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice.
Toxicology 20160701
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Activation of peroxisome proliferator-activated receptor-β/δ (PPAR-β/δ) inhibits human breast cancer cell line tumorigenicity.
Molecular cancer therapeutics 20140401
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Fenofibrate suppresses melanogenesis in B16-F10 melanoma cells via activation of the p38 mitogen-activated protein kinase pathway.
Chemico-biological interactions 20131005
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Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters 20130801
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Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.
The Journal of biological chemistry 20121102
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Protective effects of peroxisome proliferator-activated receptor agonists on human podocytes: proposed mechanisms of action.
British journal of pharmacology 20121001
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Activation of peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) prevents endothelial dysfunction in type 1 diabetic rats.
Free radical biology & medicine 20120815
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Peroxisome proliferator-activated receptor β/δ agonist GW0742 ameliorates cerulein- and taurocholate-induced acute pancreatitis in mice.
Surgery 20120701
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Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds.
Journal of medicinal chemistry 20120614
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Peroxisome proliferator-activated receptor β/δ cross talks with E2F and attenuates mitosis in HRAS-expressing cells.
Molecular and cellular biology 20120601
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GW0742, a high-affinity PPAR-δ agonist, mediates protection in an organotypic model of spinal cord damage.
Spine 20120115
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Role of peroxisome proliferator-activated receptor β agonist on angiogenesis in hindlimb ischemic diabetic rats.
Journal of diabetes and its complications 20120101
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Structural insights into human peroxisome proliferator activated receptor delta (PPAR-delta) selective ligand binding.
PloS one 20120101
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Functional characterization of peroxisome proliferator-activated receptor-β/δ expression in colon cancer.
Molecular carcinogenesis 20111101
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Effect of synthetic ligands of PPAR α, β/δ, γ, RAR, RXR and LXR on the fatty acid composition of phospholipids in mice.
Lipids 20111101
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Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.
Environmental health perspectives 20110801
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Administration of PPARβ/δ agonist reduces copper-induced liver damage in mice: possible implications in clinical practice.
Journal of clinical biochemistry and nutrition 20110701
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Activation of peroxisome proliferator-activated receptor delta inhibits streptozotocin-induced diabetic nephropathy through anti-inflammatory mechanisms in mice.
Diabetes 20110301
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Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents.
Journal of medicinal chemistry 20110210
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Emerging role of PPAR-β/δ in inflammatory process associated to experimental periodontitis.
Mediators of inflammation 20110101
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Chemoprevention of chemically induced skin tumorigenesis by ligand activation of peroxisome proliferator-activated receptor-beta/delta and inhibition of cyclooxygenase 2.
Molecular cancer therapeutics 20101201
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Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787.
Molecular pharmacology 20100901
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Activation of peroxisome proliferator-activated receptor-beta/delta attenuates myocardial ischemia/reperfusion injury in the rat.
Shock (Augusta, Ga.) 20100801
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GW0742, a selective PPAR-beta/delta agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury.
Journal of leukocyte biology 20100801
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Evidence for the role of peroxisome proliferator-activated receptor-beta/delta in the development of spinal cord injury.
The Journal of pharmacology and experimental therapeutics 20100501
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Telmisartan prevents weight gain and obesity through activation of peroxisome proliferator-activated receptor-delta-dependent pathways.
Hypertension (Dallas, Tex. : 1979) 20100401
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GW0742, a high-affinity PPAR -beta/delta agonist, inhibits acute lung injury in mice.
Shock (Augusta, Ga.) 20100401
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Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway.
The Journal of pharmacology and experimental therapeutics 20100201
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Ligand activation of peroxisome proliferator-activated receptor-beta/delta and inhibition of cyclooxygenase-2 enhances inhibition of skin tumorigenesis.
Toxicological sciences : an official journal of the Society of Toxicology 20100101
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Regulation of oligodendrocyte progenitor cell maturation by PPARδ: effects on bone morphogenetic proteins.
ASN neuro 20100101
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The PPARbeta/delta agonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension.
PloS one 20100101
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GW0742, a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice.
International journal of immunopathology and pharmacology 20100101
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PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance.
Nature medicine 20091101
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Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs.
Molecular carcinogenesis 20091001
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Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells.
Biochimica et biophysica acta 20091001
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Peroxisome proliferator-activated receptor beta activation promotes myonuclear accretion in skeletal muscle of adult and aged mice.
Pflugers Archiv : European journal of physiology 20090901
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Both the peroxisome proliferator-activated receptor delta agonist, GW0742, and ezetimibe promote reverse cholesterol transport in mice by reducing intestinal reabsorption of HDL-derived cholesterol.
Clinical and translational science 20090401
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Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPAR beta/delta) inhibits chemically induced skin tumorigenesis.
Carcinogenesis 20081201
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Ligand activation of peroxisome proliferator-activated receptor-beta/delta inhibits cell proliferation in human HaCaT keratinocytes.
Molecular pharmacology 20081101
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PPAR alpha, more than PPAR delta, mediates the hepatic and skeletal muscle alterations induced by the PPAR agonist GW0742.
Toxicological sciences : an official journal of the Society of Toxicology 20081001
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Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression.
Toxicological sciences : an official journal of the Society of Toxicology 20081001
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Effects of PPAR agonists on proliferation and differentiation in human urothelium.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080901
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Pharmacological activation of PPARbeta promotes rapid and calcineurin-dependent fiber remodeling and angiogenesis in mouse skeletal muscle.
American journal of physiology. Endocrinology and metabolism 20080801
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Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice.
Hepatology (Baltimore, Md.) 20080801
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Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARbeta/delta ligand GW0742.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080701
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Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms.
Journal of agricultural and food chemistry 20080514
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In vivo activation of peroxisome proliferator-activated receptor-delta protects the heart from ischemia/reperfusion injury in Zucker fatty rats.
The Journal of pharmacology and experimental therapeutics 20080501
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PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line.
Toxicological sciences : an official journal of the Society of Toxicology 20080301
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Peroxisome proliferator-activated receptor beta/delta activation improves angiotensin II-induced cardiac hypertrophy in vitro.
Clinical and experimental hypertension (New York, N.Y. : 1993) 20080201
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Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms.
Carcinogenesis 20080101
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Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines.
Carcinogenesis 20071201
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Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient mice.
Gastroenterology 20070701
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A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity.
Molecular pharmacology 20070501
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Short-term activation of peroxysome proliferator-activated receptor beta/delta increases fatty acid oxidation but does not restore insulin action in muscle cells from type 2 diabetic patients.
Journal of molecular medicine (Berlin, Germany) 20060901
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Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast.
Toxicology letters 20060601
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PPARdelta modulates lipopolysaccharide-induced TNFalpha inflammation signaling in cultured cardiomyocytes.
Journal of molecular and cellular cardiology 20060601
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Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts.
American journal of respiratory cell and molecular biology 20060201
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PPARbeta/delta selectively induces differentiation and inhibits cell proliferation.
Cell death and differentiation 20060101
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Differential regulation and properties of angiopoietin-like proteins 3 and 4.
Journal of lipid research 20050701
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The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice.
Atherosclerosis 20050701
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Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells.
The FEBS journal 20050601
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Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta.
Diabetes 20050401
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Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons.
Journal of neuroscience research 20040715
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Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes.
Biochemical and biophysical research communications 20040109
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Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.
Bioorganic & medicinal chemistry letters 20030505
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Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist.
Molecular endocrinology (Baltimore, Md.)
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PPARbeta activation induces rapid changes of both AMPK subunit expression and AMPK activation in mouse skeletal muscle.
Molecular endocrinology (Baltimore, Md.)
