3364-80-5 | Thiazole-4-carboxaldehyde

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$18.00	$13.00
5g	98%	in stock	$44.00	$31.00
10g	98%	in stock	$85.00	$60.00
25g	98%	in stock	$212.00	$149.00

Description

• Catalog Number: AD42997
• Chemical Name: Thiazole-4-carboxaldehyde
• CAS Number: 3364-80-5
• Molecular Formula: C4H3NOS
• Molecular Weight: 113.1377
• MDL Number: MFCD00626896
• SMILES: O=Cc1cscn1

Computed Properties

• Complexity: 76.1
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 7
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• XLogP3: 0.7

Upstream Synthesis Route

Thiazole-4-carboxaldehyde is a versatile compound widely used in chemical synthesis. It serves as a key building block in the preparation of various pharmaceuticals, agrochemicals, and fine chemicals. Due to its unique structure and reactivity, Thiazole-4-carboxaldehyde is particularly valued in organic synthesis for its ability to introduce the thiazole ring system into complex molecules. Its applications extend to the synthesis of heterocyclic compounds, which are crucial for drug discovery and development. Additionally, Thiazole-4-carboxaldehyde can act as a valuable intermediate in the construction of asymmetric carbon centers, making it indispensable in the preparation of chiral molecules with precise stereochemistry. Its role in chemical synthesis underscores its significance in modern research and development efforts across multiple industries.

Literature

• Dynamic multi-component covalent assembly for the reversible binding of secondary alcohols and chirality sensing.

  Nature chemistry 20111201

• Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters.

  Journal of medicinal chemistry 20070419

• A catch-and-release strategy for the combinatorial synthesis of 4-acylamino-1,3-thiazoles as potential CDK5 inhibitors.

  Bioorganic & medicinal chemistry letters 20031020