343306-79-6 | Sugammadex sodium

Packsize	Purity	Availability	Price	Discounted Price
1mg	≥98%	in stock	$42.00	$29.00
5mg	≥98%	in stock	$179.00	$126.00
10mg	≥98%	in stock	$313.00	$219.00
100mg	97%	in stock	$639.00	$447.00
250mg	97%	in stock	$1,371.00	$960.00
1g	97%	in stock	$4,802.00	$3,361.00
5g	97%	in stock	$21,423.00	$14,997.00

Description

• Catalog Number: AF84566
• Chemical Name: Sugammadex sodium
• CAS Number: 343306-79-6
• Molecular Formula: H2NO
• Molecular Weight: 32.0220
• MDL Number: MFCD09954145
• SMILES: N[O]

Computed Properties

• Complexity: 2790
• Covalently-Bonded Unit Count: 9
• Defined Atom Stereocenter Count: 40
• Heavy Atom Count: 136
• Hydrogen Bond Acceptor Count: 56
• Hydrogen Bond Donor Count: 16
• Rotatable Bond Count: 32

Literature

• Effects of sugammadex and rocuronium mast cell number and degranulation in rat liver.

  Anaesthesia 20121001

• Sugammadex in rocuronium anaphylaxis: dose matters.

  British journal of anaesthesia 20121001

• A randomised controlled trial comparing sugammadex and neostigmine at different depths of neuromuscular blockade in patients undergoing laparoscopic surgery.

  Anaesthesia 20120901

• Dialysability of sugammadex and its complex with rocuronium in intensive care patients with severe renal impairment.

  British journal of anaesthesia 20120901

• Use of combination of rocuronium and sugammadex in heart transplant recipients.

  Anaesthesia and intensive care 20120901

• [Anesthetic management using muscle relaxant in a patient with amyotrophic lateral sclerosis].

  Masui. The Japanese journal of anesthesiology 20120901

• Three cases of suspected sugammadex-induced hypersensitivity reactions.

  British journal of anaesthesia 20120801

• Sugammadex is not associated with QT/QTc prolongation: methodology aspects of an intravenous moxifloxacin-controlled thorough QT study.

  International journal of clinical pharmacology and therapeutics 20120801

• [Modified rapid sequence induction for Caesarian sections : case series on the use of rocuronium and sugammadex].

  Der Anaesthesist 20120801

• [Use of sugammadex in patients undergoing caesarean section using general anesthesia with rocuronium].

  Masui. The Japanese journal of anesthesiology 20120801

• [Case of anesthesia for thoracoscopic thymectomy in a pediatric patient with myasthenia gravis: reversal of rocuronium-induced neuromuscular blockade with sugammadex].

  Masui. The Japanese journal of anesthesiology 20120801

• The cyclodextrin sugammadex and anaphylaxis to rocuronium: is rocuronium still potentially allergenic in the inclusion complex form?

  Mini reviews in medicinal chemistry 20120701

• Use of rocuronium and sugammadex for caesarean delivery in a patient with myasthenia gravis.

  International journal of obstetric anesthesia 20120701

• Case of anaphylaxis induced by rocuronium treated with sugammadex.

  Revista brasileira de anestesiologia 20120701

• Use of sugammadex after neostigmine incomplete reversal of rocuronium-induced neuromuscular blockade.

  Revista brasileira de anestesiologia 20120701

• [Case of anaphylactic reaction caused by sugammadex].

  Masui. The Japanese journal of anesthesiology 20120701

• [Difficult ventilation after sugammadex administration: a case report].

  Masui. The Japanese journal of anesthesiology 20120701

• Reversal of profound rocuronium or vecuronium-induced neuromuscular block with sugammadex in isoflurane-anaesthetised dogs.

  Veterinary journal (London, England : 1997) 20120601

• Use of sugammadex in patients with a history of pulmonary disease.

  Journal of clinical anesthesia 20120601

• Rocuronium and sugammadex used effectively for electroconvulsive therapy in a patient with Brugada syndrome.

  The journal of ECT 20120601

• Suspected unexpected adverse effect of sugammadex: hypotension.

  European journal of clinical pharmacology 20120501

• Reversal of profound and 'deep' residual rocuronium-induced neuromuscular blockade by sugammadex: a neurophysiological study.

  Minerva anestesiologica 20120501

• Titration of electroconvulsive therapy: the use of rocuronium and sugammadex with adjunctive laryngeal mask.

  British journal of anaesthesia 20120501

• Sugammadex antagonising rocuronium in three patients with liver dysfunction undergoing transjugular intrahepatic portosystemic shunt.

  Anaesthesia and intensive care 20120501

• [Muscle relaxants and neuromuscular monitoring - Introduction for a safe clinical application].

  Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20120501

• Is sugammadex economically viable for routine use.

  Current opinion in anaesthesiology 20120401

• Effects of sugammadex on immunoreactivity of calcineurin in rat testes cells after neuromuscular block: a pilot study.

  Journal of molecular histology 20120401

• Use of sugammadex in a 'can't intubate, can't ventilate' situation.

  British journal of anaesthesia 20120401

• Elevated BIS and Entropy values after sugammadex or neostigmine: an electroencephalographic or electromyographic phenomenon?

  Acta anaesthesiologica Scandinavica 20120401

• Rapid sequence induction and intubation with rocuronium-sugammadex compared with succinylcholine: a randomized trial.

  British journal of anaesthesia 20120401

• Effect of sugammadex or neostigmine neuromuscular block reversal on bispectral index monitoring of propofol/remifentanil anaesthesia.

  British journal of anaesthesia 20120401

• Efficacy of rocuronium and sugammadex in a patient with dermatomyositis.

  British journal of anaesthesia 20120401

• Myths and facts in neuromuscular pharmacology. New developments in reversing neuromuscular blockade.

  Minerva anestesiologica 20120401

• Flucloxacillin and diclofenac do not cause recurrence of neuromuscular blockade after reversal with sugammadex.

  Clinical drug investigation 20120301

• The role of sugammadex in the development and modification of an allergic response to rocuronium: evidence from a cutaneous model.

  Anaesthesia 20120301

• Sugammadex: restricted vs unrestricted or selective vs non-selective?

  Anaesthesia and intensive care 20120301

• The influence of unrestricted use of sugammadex on clinical anaesthetic practice in a tertiary teaching hospital.

  Anaesthesia and intensive care 20120301

• Unrestricted access to sugammadex: impact on neuromuscular blocking agent choice, reversal practice and associated healthcare costs.

  Anaesthesia and intensive care 20120301

• A persistent 'can't intubate, can't oxygenate' crisis despite rocuronium reversal with sugammadex.

  Anaesthesia and intensive care 20120301

• Normal rocuronium sensitivity after titrated intraoperative sugammadex.

  Anaesthesia and intensive care 20120301

• Randomized comparison of sugammadex and neostigmine for reversal of rocuronium-induced muscle relaxation in morbidly obese undergoing general anaesthesia.

  British journal of anaesthesia 20120201

• Successful management of rocuronium-induced anaphylactic reactions with sugammadex: a case report.

  Journal of clinical anesthesia 20120201

• [Rapid sequence induction in a patient with Steinert myotonic dystrophy: Interest of the association of high doses of rocuronium and sugammadex].

  Annales francaises d'anesthesie et de reanimation 20120201

• [Fast recovery of haemodynamic and ventilatory functions after sugammadex bolus following rocuronium-induced anaphylactic shock refractory to conventional treatment].

  Annales francaises d'anesthesie et de reanimation 20120201

• Anesthesia and myasthenia gravis.

  Acta anaesthesiologica Scandinavica 20120101

• Neuromuscular blocking agents for electroconvulsive therapy: a systematic review.

  Acta anaesthesiologica Scandinavica 20120101

• Correlation between cardiac output and reversibility of rocuronium-induced moderate neuromuscular block with sugammadex.

  Acta anaesthesiologica Scandinavica 20120101

• Reversal of profound neuromuscular blockade with sugammadex after failure of rapid sequence endotracheal intubation: a case report.

  Revista brasileira de anestesiologia 20120101

• Effect of sugammadex on bronchial smooth muscle function in rats.

  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20120101

• [Residual neuromuscular blockade after muscle relaxants administration in neurosurgical patients].

  Anesteziologiia i reanimatologiia 20120101

• Drug-specific cyclodextrins with emphasis on sugammadex, the neuromuscular blocker rocuronium and perioperative anaphylaxis: implications for drug allergy.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20111201

• Comparison of recovery times from rocuronium-induced muscle relaxation after reversal with three different doses of sugammadex and succinylcholine during electroconvulsive therapy.

  Journal of anesthesia 20111201

• Development and potential clinical impairment of ultra-short-acting neuromuscular blocking agents.

  British journal of anaesthesia 20111201

• [Anesthetic management for electroconvulsive therapy using rocuronium bromide and sugammadex sodium in a patient with suspected malignant syndrome].

  Masui. The Japanese journal of anesthesiology 20111201

• [Use of sugammadex in a patient with amyotrophic lateral sclerosis].

  Masui. The Japanese journal of anesthesiology 20111201

• [Sugammadex in a man with a transplanted kidney: a case report].

  Revista espanola de anestesiologia y reanimacion 20111201

• [Sugammadex, efficacious in reversing a neuromuscular block in a woman with Becker muscular dystrophy].

  Revista espanola de anestesiologia y reanimacion 20111201

• [Rocuronium used after sugammadex].

  Revista espanola de anestesiologia y reanimacion 20111201

• [Rocuronium-sugammadex complex in the reversal of neuromuscular blockade after implantation of an endobronchial stent following lung transplant].

  Revista espanola de anestesiologia y reanimacion 20111201

• [Rocuronium used in rapid sequence intubation and reversal with sugammadex in a patient with myasthenia gravis].

  Revista espanola de anestesiologia y reanimacion 20111201

• [Extremely prolonged neuromuscular block after a single dose of rocuronium].

  Annales francaises d'anesthesie et de reanimation 20111101

• [Sugammadex and renal failure: a case report].

  Annales francaises d'anesthesie et de reanimation 20111001

• [Clinical evaluation of post-surgical bleeding after a sugammadex injection].

  Annales francaises d'anesthesie et de reanimation 20111001

• Recurarization after sugammadex reversal in an obese patient.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20111001

• Intraoperative reversal of neuromuscular block with sugammadex or neostigmine during extreme lateral interbody fusion, a novel technique for spine surgery.

  Journal of anesthesia 20111001

• Case report: sugammadex used to successfully reverse vecuronium-induced neuromuscular blockade in a 7-month-old infant.

  Paediatric anaesthesia 20111001

• [Use of sugammadex in a patient with narrow angle glaucoma].

  Masui. The Japanese journal of anesthesiology 20111001

• [A two-year-old patient who received readministration of rocuronium for re-operation 30 minutes after sugammadex reversal].

  Masui. The Japanese journal of anesthesiology 20111001

• [Successful use of sugammadex in a muscular dystrophy patient].

  Masui. The Japanese journal of anesthesiology 20111001

• Population pharmacokinetic-pharmacodynamic analysis for sugammadex-mediated reversal of rocuronium-induced neuromuscular blockade.

  British journal of clinical pharmacology 20110901

• Sugammadex, a promising reversal drug. A review of clinical trials.

  Reviews on recent clinical trials 20110901

• The use of rocuronium and sugammadex in a patient with a history of suxamethonium allergy.

  Anaesthesia 20110901

• [Administration of sugammadex to a patient with myasthenia gravis with fade of the train-of-four ratio].

  Masui. The Japanese journal of anesthesiology 20110901

• Repeat dosing of rocuronium after reversal of neuromuscular block by sugammadex.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20110801

• Ideal versus corrected body weight for dosage of sugammadex in morbidly obese patients.

  Anaesthesia 20110801

• A further case of rocuronium-induced anaphylaxis treated with sugammadex.

  British journal of anaesthesia 20110801

• [Recovery from rocuronium by sugammadex does not affect motor evoked potentials].

  Masui. The Japanese journal of anesthesiology 20110801

• General anesthesia for electroconvulsive therapy with Brugada electrocardiograph pattern.

  The journal of medical investigation : JMI 20110801

• Re-establishment of neuromuscular block by rocuronium after sugammadex administration.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20110701

• Rocuronium and sugammadex for rapid sequence induction of obstetric general anaesthesia.

  Acta anaesthesiologica Scandinavica 20110701

• Train-of-four ratio recovery often precedes twitch recovery when neuromuscular block is reversed by sugammadex.

  Acta anaesthesiologica Scandinavica 20110701

• From d-tubocurarine to sugammadex: the contributions of T. Cecil Gray to modern anaesthetic practice.

  British journal of anaesthesia 20110701

• The Proseal laryngeal mask airway and elective caesarean section.

  Anaesthesia and intensive care 20110701

• Electroconvulsive therapy using rocuronium and sugammadex in patient with neuroleptic malignant syndrome.

  Anaesthesia and intensive care 20110701

• Rocuronium and sugammadex as a novel management strategy in a patient with plasmacholinesterase deficiency presenting for electroconvulsive therapy.

  Anaesthesia and intensive care 20110701

• Determination of sugammadex in human plasma, urine, and dialysate using a high-performance liquid chromatography/tandem mass spectrometry assay.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110601

• Reversibility of rocuronium-induced profound neuromuscular block with sugammadex in younger and older patients.

  British journal of anaesthesia 20110601

• Unexpected failure of rocuronium-mediated neuromuscular blockade.

  Anaesthesia 20110601

• Rocuronium-induced anaphylaxis is probably not mitigated by sugammadex: evidence from an in vitro experiment.

  Anaesthesia 20110601

• Sugammadex and rocuronium-induced anaphylaxis.

  British journal of anaesthesia 20110601

• Sugammadex administration results in arousal from intravenous anaesthesia: a clinical and electroencephalographic observation.

  British journal of anaesthesia 20110601

• [Use of sugammadex in a patient with limb girdle muscular dystrophy].

  Masui. The Japanese journal of anesthesiology 20110601

• [Case report: a normal dose of rocuronium achieved the desired effect in a short time after the administration of sugammadex during reoperation].

  Masui. The Japanese journal of anesthesiology 20110501

• The use of sugammadex to reverse rocuronium in a patient with myotonic dystrophy.

  Anaesthesia and intensive care 20110501

• Sugammadex reverses neuromuscular block induced by 3-desacetyl-vecuronium, an active metabolite of vecuronium, in the anaesthetised rhesus monkey.

  European journal of anaesthesiology 20110401

• Reversal of rocuronium-induced neuromuscular block by sugammadex is independent of renal perfusion in anesthetized cats.

  Journal of anesthesia 20110401

• Use of rocuronium-sugammadex, an alternative to succinylcholine, as a muscle relaxant during electroconvulsive therapy.

  Journal of anesthesia 20110401

• [Effective reversal of muscle relaxation by rocuronium using sugammadex in a patient with myasthenia gravis undergoing laparoscopic cholecystectomy].

  Masui. The Japanese journal of anesthesiology 20110401

• Rocuronium antagonized by sugammadex for series of electroconvulsive therapy (ECT) in a patient with pseudocholinesterase deficiency.

  The journal of ECT 20110301

• Role of rocuronium and sugammadex in rapid sequence induction in pregnancy.

  British journal of anaesthesia 20110301

• Allergy to low dose sugammadex.

  Anaesthesia 20110301

• Can sugammadex save a patient in a simulated 'cannot intubate, cannot ventilate' situation?

  Anaesthesia 20110301

• Sugammadex following rocuronium rapid sequence induction.

  Anaesthesia 20110301

• Sugammadex for rocuronium rapid sequence induction.

  Anaesthesia 20110301

• The use of rocuronium in a patient with cystic fibrosis and end-stage lung disease made safe by sugammadex reversal.

  Anaesthesia and intensive care 20110301

• The use of sugammadex in a patient with myotonic dystrophy.

  European journal of anaesthesiology 20110201

• Sugammadex in the management of rocuronium-induced anaphylaxis.

  British journal of anaesthesia 20110201

• Efficacy, safety, and pharmacokinetics of sugammadex for the reversal of rocuronium-induced neuromuscular blockade in elderly patients.

  Anesthesiology 20110201

• Availability and storage of sugammadex for emergency use.

  Anaesthesia 20110201

• Sugammadex and rescue reversal.

  Anaesthesia 20110201

• Can sugammadex save a patient in a simulated 'cannot intubate, cannot ventilate' scenario?

  Anaesthesia 20110201

• A case where rocuronium was unable to achieve neuromuscular block immediately after sugammadex administration.

  The journal of medical investigation : JMI 20110201

• The duration of residual neuromuscular block after administration of neostigmine or sugammadex at two visible twitches during train-of-four monitoring.

  Anesthesia and analgesia 20110101

• Assessment of the potential for displacement interactions with sugammadex: a pharmacokinetic-pharmacodynamic modelling approach.

  Clinical drug investigation 20110101

• Unexpected failure of rocuronium-mediated neuromuscular blockade.

  Anaesthesia 20110101

• Use of sugammadex for reversal of neuromuscular blockade in 2 patients requiring intraoperative neurophysiological monitoring.

  Journal of neurosurgical anesthesiology 20110101

• [Sugammadex, a new drug for reversion of muscle relaxants].

  Lijecnicki vjesnik 20110101

• Anesthesia for laparoscopic surgery in a patient with myotonic dystrophy (Steinert's disease): beneficial use of sugammadex, but incorrect use of pethidine: a case report.

  Acta anaesthesiologica Belgica 20110101

• Reversal of rocuronium-induced neuromuscular block with sugammadex and resulting histopathological effects in rat kidneys.

  Renal failure 20110101

• [Identification of the lumbosacral nerve plexus during the extreme lateral interbody fusion procedure].

  Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca 20110101

• Sugammadex reversal of rocuronium-induced neuromuscular block in Caesarean section patients: a series of seven cases.

  British journal of anaesthesia 20101101

• Neostigmine versus sugammadex: which, when, and how much?

  Anesthesiology 20101101

• Sugammadex rapidly reverses moderate rocuronium- or vecuronium-induced neuromuscular block during sevoflurane anaesthesia: a dose-response relationship.

  British journal of anaesthesia 20101101

• Sugammadex and neostigmine dose-finding study for reversal of shallow residual neuromuscular block.

  Anesthesiology 20101101

• Sugammadex compared with neostigmine/glycopyrrolate for routine reversal of neuromuscular block: a systematic review and economic evaluation.

  British journal of anaesthesia 20101101

• Sugammadex for reversal of neuromuscular block after rapid sequence intubation: a systematic review and economic assessment.

  British journal of anaesthesia 20101101

• Sugammadex in anesthesia practice.

  Expert opinion on pharmacotherapy 20101101

• Successful use of rocuronium and sugammadex in a patient with myasthenia.

  European journal of anaesthesiology 20101001

• A randomized simultaneous comparison of acceleromyography with a peripheral nerve stimulator for assessing reversal of rocuronium-induced neuromuscular blockade with sugammadex.

  European journal of anaesthesiology 20101001

• Repeat dosing of rocuronium 1.2 mg kg-1 after reversal of neuromuscular block by sugammadex 4.0 mg kg-1 in anaesthetized healthy volunteers: a modelling-based pilot study.

  British journal of anaesthesia 20101001

• Reversal of profound rocuronium block monitored in three muscle groups with sugammadex in ponies.

  British journal of anaesthesia 20101001

• Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.

  European journal of anaesthesiology 20101001

• Reversal of neuromuscular blockade by sugammadex does not affect EEG derived indices of depth of anesthesia.

  Journal of clinical monitoring and computing 20101001

• [Case-Report: Reversal of a deep neuromuscular block with sugammadex after rapid sequence induction with high-dose rocuronium bromide].

  Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20101001

• Sugammadex and cholinesterase inhibitors.

  Anaesthesia and intensive care 20100901

• Rocuronium and sugammadex in myotonic dystrophy.

  Anaesthesia and intensive care 20100901

• Can sugammadex save a patient in a simulated 'cannot intubate, cannot ventilate' situation?

  Anaesthesia 20100901

• Sugammadex: a selective relaxant-binding agent providing rapid reversal.

  Current opinion in anaesthesiology 20100801

• Reversal of prolonged rocuronium neuromuscular blockade with sugammadex in an obstetric patient with transverse myelitis.

  International journal of obstetric anesthesia 20100701

• Sugammadex for the reversal of muscle relaxation in general anaesthesia: a systematic review and economic assessment.

  Health technology assessment (Winchester, England) 20100701

• Sugammadex in patients with myasthenia gravis.

  Anaesthesia 20100601

• Cochrane corner: sugammadex, a selective reversal medication for preventing postoperative residual neuromuscular blockade.

  Anesthesia and analgesia 20100401

• The use of sugammadex in a patient with myasthenia gravis.

  Anaesthesia 20100301

• Successful use of rocuronium and sugammadex in an anticipated difficult airway scenario.

  Anaesthesia and intensive care 20100301

• A new approach to anesthesia management in myasthenia gravis: reversal of neuromuscular blockade by sugammadex.

  Revista espanola de anestesiologia y reanimacion 20100301

• [Sugammadex, a novel drug for neuromuscular blockade reversal].

  Revista espanola de anestesiologia y reanimacion 20100201

• Sugammadex provides faster reversal of vecuronium-induced neuromuscular blockade compared with neostigmine: a multicenter, randomized, controlled trial.

  Anesthesia and analgesia 20100101

• A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.

  Anesthesia and analgesia 20100101

• Reduced clearance of rocuronium and sugammadex in patients with severe to end-stage renal failure: a pharmacokinetic study.

  British journal of anaesthesia 20100101

• Mitigation of rocuronium-induced anaphylaxis by sugammadex: the great unknown.

  Anaesthesia 20100101

• [Problem of neuromuscular block reversion: neostigmine and sugammadex].

  Anesteziologiia i reanimatologiia 20100101

• Effects of sugammadex doses up to 32 mg/kg alone or in combination with rocuronium or vecuronium on QTc prolongation: a thorough QTc study.

  Clinical drug investigation 20100101

• [The introduction of sugammadex into the clinical practice in Croatia--the role of succinylcholine re-visited].

  Lijecnicki vjesnik 20100101

• Safety, tolerability and pharmacokinetics of sugammadex using single high doses (up to 96 mg/kg) in healthy adult subjects: a randomized, double-blind, crossover, placebo-controlled, single-centre study.

  Clinical drug investigation 20100101

• Sugammadex--a short review and clinical recommendations for the cardiac anesthesiologist.

  Annals of cardiac anaesthesia 20100101

• [Sugammadex--two years in clinical practice].

  Anestezjologia intensywna terapia 20100101

• Reversal of rocuronium-induced profound neuromuscular block by sugammadex in Duchenne muscular dystrophy.

  Paediatric anaesthesia 20091201

• Sugammadex, a selective reversal medication for preventing postoperative residual neuromuscular blockade.

  The Cochrane database of systematic reviews 20091007

• Safety and efficacy of sugammadex for the reversal of rocuronium-induced neuromuscular blockade in cardiac patients undergoing noncardiac surgery.

  European journal of anaesthesiology 20091001

• Sugammadex: the first selective binding reversal agent for neuromuscular block.

  Journal of clinical anesthesia 20090901

• [Sugammadex: a new approach to muscle relaxation and its reversal].

  Annales francaises d'anesthesie et de reanimation 20090901

• [Pharmacology of sugammadex].

  Annales francaises d'anesthesie et de reanimation 20090901

• [Indications and clinical use of sugammadex].

  Annales francaises d'anesthesie et de reanimation 20090901

• [Sugammadex: something new to improve patient safety or simply a gadget?].

  Annales francaises d'anesthesie et de reanimation 20090901

• Rapid sequence intubation: a review of recent evidences.

  Reviews on recent clinical trials 20090901

• Update on neuromuscular pharmacology.

  Current opinion in anaesthesiology 20090801

• Reversal of neuromuscular block.

  British journal of anaesthesia 20090701

• Reversal of neuromuscular blockade by sugammadex after continuous infusion of rocuronium in patients randomized to sevoflurane or propofol maintenance anesthesia.

  Anesthesiology 20090701

• Rapid sequence induction in obstetrics revisited.

  Current opinion in anaesthesiology 20090601

• An update on sugammadex sodium.

  AANA journal 20090601

• Reversal of profound neuromuscular block by sugammadex administered three minutes after rocuronium: a comparison with spontaneous recovery from succinylcholine.

  Anesthesiology 20090501

• Sugammadex: a selective relaxant binding agent for reversal of neuromuscular block.

  Expert review of neurotherapeutics 20090501

• A novel approach to reversal of neuromuscular blockade.

  Minerva anestesiologica 20090501

• [Sugammadex--a new era in the antagonsim of muscle relaxants].

  Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20090501

• When the model does not fit the data, the model is wrong.

  Anesthesiology 20090401

• Cyclodextrins and the emergence of sugammadex.

  Anaesthesia 20090301

• Sugammadex in clinical practice.

  Anaesthesia 20090301

• Clinical implications of sugammadex.

  Anaesthesia 20090301

• Patient safety revisited: reliability is paramount.

  Anesthesia and analgesia 20090301

• The effect of residual neuromuscular blockade on the speed of reversal with sugammadex.

  Anesthesia and analgesia 20090301

• Have we learned how to relax our patients, by thinking outside the box?

  Journal of critical care 20090301

• Preclinical pharmacology of sugammadex.

  Journal of critical care 20090301

• Neuromuscular transmission: new concepts and agents.

  Journal of critical care 20090301

• Clinical implications of new neuromuscular concepts and agents: so long, neostigmine! So long, sux!

  Journal of critical care 20090301

• Reversal of rocuronium-induced neuromuscular blockade with sugammadex in pediatric and adult surgical patients.

  Anesthesiology 20090201

• [Sugammadex. New pharmacological concept for antagonizing rocuronium and vecuronium].

  Der Anaesthesist 20090101

• Pharmacokinetic-pharmacodynamic model for the reversal of neuromuscular blockade by sugammadex.

  Anesthesiology 20090101

• The impact of Alzheimer's disease medication on muscle relaxants.

  Anaesthesia and intensive care 20090101

• Sugammadex: a review of its use in anaesthetic practice.

  Drugs 20090101

• Reversal of neuromuscular block with a selective relaxant-binding agent: sugammadex.

  American journal of therapeutics 20090101

• [Efficacy of sugammadex in the reversal of neuromuscular blockade induced by rocuronium in long-duration surgery: under inhaled vs. intravenous anesthesia].

  Revista espanola de anestesiologia y reanimacion 20090101

• Reversal of profound rocuronium-induced blockade with sugammadex: a randomized comparison with neostigmine.

  Anesthesiology 20081101

• Multicentre, parallel-group, comparative trial evaluating the efficacy and safety of sugammadex in patients with end-stage renal failure or normal renal function.

  British journal of anaesthesia 20081001

• Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing.

  British journal of anaesthesia 20080901

• Reversal of profound, high-dose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose-finding, safety assessor-blinded, phase II trial.

  Anesthesiology 20080801

• [Reversal of neuromuscular blockade and complications of remaining blocking effect].

  Masui. The Japanese journal of anesthesiology 20080701

• [Muscle relaxants in ambulatory anesthesia].

  Masui. The Japanese journal of anesthesiology 20080701

• [Does rocuronium displace the position of suxamethonium?].

  Masui. The Japanese journal of anesthesiology 20080701

• Sugammadex: a cyclodextrin to reverse neuromuscular blockade in anaesthesia.

  Expert opinion on pharmacotherapy 20080601

• Reversal of rocuronium-induced neuromuscular block with sugammadex is faster than reversal of cisatracurium-induced block with neostigmine.

  British journal of anaesthesia 20080501

• Safety and tolerability of single intravenous doses of sugammadex administered simultaneously with rocuronium or vecuronium in healthy volunteers.

  British journal of anaesthesia 20080301

• Non-steroidal neuromuscular blocking agents to re-establish paralysis after reversal of rocuronium-induced neuromuscular block with sugammadex.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20080201

• Neuromuscular blockade in cardiac surgery: an update for clinicians.

  Annals of cardiac anaesthesia 20080101

• Molecule of the month. Sugammadex sodium.

  Drug news & perspectives 20071101

• Was it a true emergency?

  Anesthesia and analgesia 20070901

• Pseudo-emergent use of an investigational drug.

  Anesthesia and analgesia 20070901

• Where's the Fire?

  Anesthesia and analgesia 20070901

• Urgent usage of sugammadex to treat residual neuromuscular blockade in the PACU.

  Anesthesia and analgesia 20070901

• Sugammadex-rocuronium dosing.

  Anesthesia and analgesia 20070901

• Sugammadex: an opportunity for more thinking or more cookbook medicine?

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20070901

• Sugammadex: a novel agent for the reversal of neuromuscular blockade.

  Pharmacotherapy 20070801

• Reversal of rocuronium-induced (1.2 mg/kg) profound neuromuscular block by sugammadex: a multicenter, dose-finding and safety study.

  Anesthesiology 20070801

• Reversal of rocuronium-induced (1.2 mg kg-1) profound neuromuscular block by accidental high dose of sugammadex (40 mg kg-1).

  British journal of anaesthesia 20070501

• Early reversal of profound rocuronium-induced neuromuscular blockade by sugammadex in a randomized multicenter study: efficacy, safety, and pharmacokinetics.

  Anesthesiology 20070501

• [Sugammadex, a revolutionary new drug to reverse neuromuscular block].

  Revista espanola de anestesiologia y reanimacion 20070401

• A randomized, dose-finding, phase II study of the selective relaxant binding drug, Sugammadex, capable of safely reversing profound rocuronium-induced neuromuscular block.

  Anesthesia and analgesia 20070301

• Reversal of rocuronium-induced neuromuscular block with the novel drug sugammadex is equally effective under maintenance anesthesia with propofol or sevoflurane.

  Anesthesia and analgesia 20070301

• Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine.

  Anesthesia and analgesia 20070301

• Sugammadex: another milestone in clinical neuromuscular pharmacology.

  Anesthesia and analgesia 20070301

• A temporary decrease in twitch response during reversal of rocuronium-induced muscle relaxation with a small dose of sugammadex.

  Anesthesia and analgesia 20070301

• Emergency use of sugammadex after failure of standard reversal drugs.

  Anesthesia and analgesia 20070301

• Effective reversal of moderate rocuronium- or vecuronium-induced neuromuscular block with sugammadex, a selective relaxant binding agent.

  Anesthesiology 20070201

• Which muscle relaxants should be used in day surgery and when.

  Current opinion in anaesthesiology 20061201

• Time course of action of sugammadex (Org 25969) on rocuronium-induced block in the Rhesus monkey, using a simple model of equilibration of complex formation.

  British journal of anaesthesia 20061101

• New drug sugammadex: a selective relaxant binding agent.

  AANA journal 20061001

• The doughnut and the hole: a new pharmacological concept for anaesthetists.

  British journal of anaesthesia 20060801

• First human exposure to Org 25969.

  Anesthesiology 20060801

• [Sugammadex (Org 25969, modified gamma-cyclodextrin)].

  Masui. The Japanese journal of anesthesiology 20060701

• Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey.

  British journal of anaesthesia 20060401

• Sugammadex: a revolutionary approach to neuromuscular antagonism.

  Anesthesiology 20060401

• Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety study.

  Anesthesiology 20060401

• Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys.

  Anesthesiology 20060401

• Org 25969 (sugammadex), a selective relaxant binding agent for antagonism of prolonged rocuronium-induced neuromuscular block.

  British journal of anaesthesia 20060101

• First human exposure of Org 25969, a novel agent to reverse the action of rocuronium bromide.

  Anesthesiology 20051001

• Novel pharmacological approaches for the antagonism of neuromuscular blockade.

  AANA journal 20050201

• Reversal of neuromuscular blockade and simultaneous increase in plasma rocuronium concentration after the intravenous infusion of the novel reversal agent Org 25969.

  Anesthesiology 20030901

• [Cyclodextrin. A new concept for antagonizing muscle relaxants].

  Der Anaesthesist 20021101

• Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activity relationships.

  Journal of medicinal chemistry 20020425

• A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host.

  Angewandte Chemie (International ed. in English) 20020118

• Liquid chromatography/mass spectrometric bioanalysis of a modified gamma-cyclodextrin (Org 25969) and Rocuronium bromide (Org 9426) in guinea pig plasma and urine: its application to determine the plasma pharmacokinetics of Org 25969.

  Rapid communications in mass spectrometry : RCM 20020101