34540-22-2 | Madecassoside

Packsize	Purity	Availability	Price	Discounted Price
5mg	95%(HPLC)	in stock	$57.00	$40.00
25mg	95%(HPLC)	in stock	$114.00	$80.00
100mg	95%(HPLC)	in stock	$291.00	$204.00

Description

• Catalog Number: AI48454
• Chemical Name: Madecassoside
• CAS Number: 34540-22-2
• Molecular Formula: C48H78O20
• Molecular Weight: 975.1209
• MDL Number: MFCD03411893
• SMILES: OC[C@H]1O[C@@H](OC[C@H]2O[C@@H](OC(=O)[C@@]34CC[C@H]([C@@H]([C@H]4C4=CC[C@H]5[C@@]([C@]4(CC3)C)(C)C[C@@H](O)[C@@H]3[C@]5(C)C[C@H]([C@@H]([C@@]3(C)CO)O)O)C)C)[C@@H]([C@H]([C@@H]2O)O)O)[C@@H]([C@H]([C@@H]1O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O)O)O

Computed Properties

• Complexity: 1860
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 28
• Heavy Atom Count: 68
• Hydrogen Bond Acceptor Count: 20
• Hydrogen Bond Donor Count: 13
• Rotatable Bond Count: 10
• XLogP3: -1.2

Literature

• Madecassoside, a triterpenoid saponin isolated from Centella asiatica herbs, protects endothelial cells against oxidative stress.

  Journal of biochemical and molecular toxicology 20121001

• Development and validation of high-performance liquid chromatography/electrospray ionization mass spectrometry for assay of madecassoside in rat plasma and its application to pharmacokinetic study.

  Biomedical chromatography : BMC 20120101

• In vitro inhibitory effects of asiaticoside and madecassoside on human cytochrome P450.

  Toxicology in vitro : an international journal published in association with BIBRA 20110601

• Upregulation of phytosterol and triterpene biosynthesis in Centella asiatica hairy roots overexpressed ginseng farnesyl diphosphate synthase.

  Plant cell reports 20100401

• Contact dermatitis due to Centella asiatica.

  Contact dermatitis 20100101

• Madecassoside attenuates inflammatory response on collagen-induced arthritis in DBA/1 mice.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20090601

• Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin.

  Experimental dermatology 20081101

• Enrichment and purification of madecassoside and asiaticoside from Centella asiatica extracts with macroporous resins.

  Journal of chromatography. A 20080606

• Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice.

  Planta medica 20080601

• [Preparation of asiaticoside and madecassoside from the extract of Centella asiatica (L.) Urb using preparative high performance liquid chromatography].

  Se pu = Chinese journal of chromatography 20080501

• Madecassoside reduces ischemia-reperfusion injury on regional ischemia induced heart infarction in rat.

  Biological & pharmaceutical bulletin 20080301

• Simultaneous quantitation of three major triterpenoid glycosides in Centella asiatica extracts by high performance liquid chromatography with evaporative light scattering detection.

  Biomedical chromatography : BMC 20080201

• [Protective effect of madecassoside against reperfusion injury after regional ischemia in rabbit heart in vivo].

  Yao xue xue bao = Acta pharmaceutica Sinica 20070501

• Cytotoxic cycloartane triterpene saponins from Actaea asiatica.

  Journal of natural products 20061001

• Identification of triterpenoid compounds of Centella asiatica by thin-layer chromatography and mass spectrometry.

  Biomedical chromatography : BMC 20060201

• [Effect of madecassoside on depression behavior of mice and activities of MAO in different brain regions of rats].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20041101

• In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20010501