3544-24-9 | 3-Aminobenzamide

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$6.00	$4.00
250mg	98%	in stock	$7.00	$5.00
1g	98%	in stock	$9.00	$6.00
5g	98%	in stock	$31.00	$22.00
10g	95%	in stock	$31.00	$22.00

Description

• Catalog Number: AB49276
• Chemical Name: 3-Aminobenzamide
• CAS Number: 3544-24-9
• Molecular Formula: C7H8N2O
• Molecular Weight: 136.1512
• MDL Number: MFCD00007989
• SMILES: Nc1cccc(c1)C(=O)N
• NSC Number: 36962

Computed Properties

• Complexity: 136
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: -0.5

Literature

• Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.

  The Journal of biological chemistry 20160520

• Poly(ADP-ribosyl)ation enhances H-RAS protein stability and causes abnormal cell cycle progression in human TK6 lymphoblastoid cells treated with hydroquinone.

  Chemico-biological interactions 20150805

• A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.

  Cell metabolism 20141104

• Inhibition of poly(ADP-ribose) polymerase attenuates acute kidney injury in sodium taurocholate-induced acute pancreatitis in rats.

  Pancreas 20121101

• NGF promotes long-term memory formation by activating poly(ADP-ribose)polymerase-1.

  Neuropharmacology 20121101

• Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats.

  Diabetes/metabolism research and reviews 20120501

• Increased poly(ADP-ribosyl)ation in peripheral leukocytes and the reperfused myocardium tissue of rats with ischemia/reperfusion injury: prevention by 3-aminobenzamide treatment.

  Shock (Augusta, Ga.) 20120501

• Poly(ADP-ribose) polymerase inhibition improves erectile function by activation of nitric oxide/cyclic guanosine monophosphate pathway in diabetic rats.

  The journal of sexual medicine 20120501

• Preventive Effect of Cichorium Intybus L. Two Extracts on Cerulein-induced Acute Pancreatitis in Mice.

  International journal of preventive medicine 20120501

• 3'-5' phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1 in vivo.

  The Biochemical journal 20120415

• Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors.

  European journal of medicinal chemistry 20120401

• Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1.

  Biochemical pharmacology 20120315

• Picolinate ruthenium(II)-arene complex with in vitro antiproliferative and antimetastatic properties: comparison to a series of ruthenium(II)-arene complexes with similar structure.

  Journal of inorganic biochemistry 20120301

• Novel pathway of centrosome amplification that does not require DNA lesions.

  Cancer science 20120201

• ADP-ribose polymers localized on Ctcf-Parp1-Dnmt1 complex prevent methylation of Ctcf target sites.

  The Biochemical journal 20120115

• Poly(ADP-Ribose) polymerase 1 (PARP-1) regulates ribosomal biogenesis in Drosophila nucleoli.

  PLoS genetics 20120101

• Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema.

  Journal of inflammation (London, England) 20120101

• Post-Translational Modifications of Kaposi's Sarcoma-Associated Herpesvirus Regulatory Proteins - SUMO and KSHV.

  Frontiers in microbiology 20120101

• Niacinamide mitigated the acute lung injury induced by phorbol myristate acetate in isolated rat's lungs.

  Journal of biomedical science 20120101

• Adaptive response in mice exposed to 900 MHz radiofrequency fields: primary DNA damage.

  PloS one 20120101

• Poly (ADP-ribose) polymerase plays an important role in intermittent hypoxia-induced cell death in rat cerebellar granule cells.

  Journal of biomedical science 20120101

• Increased activity of cell surface peptidases in HeLa cells undergoing UV-induced apoptosis is not mediated by caspase 3.

  International journal of molecular sciences 20120101

• Chemical PARP inhibition enhances growth of Arabidopsis and reduces anthocyanin accumulation and the activation of stress protective mechanisms.

  PloS one 20120101

• [Suppressing poly(ADP-ribose)polymerase-1 inhibits tau phosphorylation in HEK293/tau441 cells].

  Sheng li xue bao : [Acta physiologica Sinica] 20111225

• Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride.

  Journal of enzyme inhibition and medicinal chemistry 20111201

• Chemotherapy sensitivity recovery of prostate cancer cells by functional inhibition and knock down of multidrug resistance proteins.

  The Prostate 20111201

• Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity.

  Molecular and cellular biochemistry 20111201

• Morphological and functional evaluation of an animal model for the retinal degeneration induced by N-methyl-N-nitrosourea.

  Anatomy & cell biology 20111201

• Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.

  Molecular cancer therapeutics 20111001

• Asbestos exposure affects poly(ADP-ribose) polymerase-1 activity: role in asbestos-induced carcinogenesis.

  Mutagenesis 20110901

• PARP1 inhibitors attenuate AKT phosphorylation via the upregulation of PHLPP1.

  Biochemical and biophysical research communications 20110826

• Association of sperm morphology and the sperm deformity index (SDI) with poly (ADP-ribose) polymerase (PARP) cleavage inhibition.

  Fertility and sterility 20110630

• PARP inhibition prevents oxidative injury of bladder induced by acute urinary retention and subsequent emptying.

  Apoptosis : an international journal on programmed cell death 20110601

• [Effect of erythropoietin on proinflammatory factors of human monocytes and its mechanisms].

  Zhongguo shi yan xue ye xue za zhi 20110601

• Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins.

  Neurotoxicity research 20110501

• Lipoxygenases and poly(ADP-ribose) polymerase in amyloid beta cytotoxicity.

  Neurochemical research 20110501

• The poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide suppresses cell growth and migration, enhancing suppressive effects of cisplatin in osteosarcoma cells.

  Oncology reports 20110501

• Metal-based inhibition of poly(ADP-ribose) polymerase--the guardian angel of DNA.

  Journal of medicinal chemistry 20110414

• Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death.

  Cellular and molecular life sciences : CMLS 20110401

• PARP inhibition restores erectile function by suppressing corporal smooth muscle apoptosis in diabetic rats.

  The journal of sexual medicine 20110401

• Synthesis and preliminary evaluation of selected 2-aryl-5(6)-nitro- 1H-benzimidazole derivatives as potential anticancer agents.

  Archives of pharmacal research 20110201

• Age-related loss of stress-induced nuclear proteasome activation is due to low PARP-1 activity.

  Free radical biology & medicine 20110101

• Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks.

  Genome integrity 20110101

• The CCCTC-binding factor (CTCF) of Drosophila contributes to the regulation of the ribosomal DNA and nucleolar stability.

  PloS one 20110101

• LRP16 integrates into NF-κB transcriptional complex and is required for its functional activation.

  PloS one 20110101

• Recombination phenotypes of the NCI-60 collection of human cancer cells.

  BMC molecular biology 20110101

• Low doses of 3-aminobenzamide, a poly(ADP-ribose) polymerase inhibitor, stimulate angiogenesis by regulating expression of urokinase type plasminogen activator and matrix metalloprotease 2.

  Vascular cell 20110101

• Promising molecular targeted therapies in breast cancer.

  Indian journal of pharmacology 20110101

• Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1.

  PloS one 20110101

• Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-β Induced Smad3 activation in vascular smooth muscle cell.

  PloS one 20110101

• Hepatoprotective effects of select water-soluble PARP inhibitors in a carbon tetrachloride model.

  International journal of critical illness and injury science 20110101

• Effects of 3-aminobenzamide on unilateral testicular ischemia-reperfusion injury: what is the role of PARP inhibition?

  Canadian journal of physiology and pharmacology 20101201

• Increased levels of p53 and PARP-1 in EL-4 cells probably related with the immune adaptive response induced by low dose ionizing radiation in vitro.

  Biomedical and environmental sciences : BES 20101201

• Targeting poly(ADP-ribose) polymerase activity for cancer therapy.

  Cellular and molecular life sciences : CMLS 20101101

• Dietary t10,c12-CLA but not c9,t11 CLA reduces adipocyte size in the absence of changes in the adipose renin-angiotensin system in fa/fa Zucker rats.

  Lipids 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Poly(ADP-ribose) polymerase inhibitor, 3-aminobenzamide, protects against experimental immune ovarian failure in mice.

  Reproductive biology 20101101

• Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.

  Aging 20101001

• Diabetic cystopathy is associated with PARP/JNK/mitochondrial apoptotic pathway-mediated bladder apoptosis.

  Neurourology and urodynamics 20100901

• Nickel modifies the cytotoxicity of hexavalent chromium in human dermal fibroblasts.

  Toxicology letters 20100816

• Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway.

  Science (New York, N.Y.) 20100702

• Fertilization capacity with rainbow trout DNA-damaged sperm and embryo developmental success.

  Reproduction (Cambridge, England) 20100601

• Effect of acute poly(ADP-ribose) polymerase inhibition by 3-AB on blood-brain barrier permeability and edema formation after focal traumatic brain injury in rats.

  Journal of neurotrauma 20100601

• Inhibition of acute pulmonary and systemic inflammation by 1,7-dimethylxanthine.

  European journal of pharmacology 20100310

• Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.

  Biochemistry 20100216

• Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).

  Bioorganic & medicinal chemistry letters 20100115

• Disruption of poly(ADP-ribosyl)ation mechanisms alters responses of Arabidopsis to biotic stress.

  Plant physiology 20100101

• PISA, a novel pharmacodynamic assay for assessing poly(ADP-ribose) polymerase (PARP) activity in situ.

  Journal of pharmacological and toxicological methods 20100101

• BRCA1 as a Therapeutic Target in Sporadic Epithelial Ovarian Cancer.

  Journal of oncology 20100101

• Relationship between DNA repair and formation of sister chromatid exchanges and chromatid aberrations under the influence of poly(ADP-ribose) polymerase inhibition by 3-aminobenzamide.

  Cytogenetic and genome research 20100101

• Modular insulators: genome wide search for composite CTCF/thyroid hormone receptor binding sites.

  PloS one 20100101

• A novel PARP inhibitor L-2286 in a rat model of impact acceleration head injury: an immunohistochemical and behavioral study.

  International journal of molecular sciences 20100101

• Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy.

  PloS one 20100101

• Inhibition of poly (ADP-Ribose) polymerase-1 in telomerase deficient mouse embryonic fibroblasts increases arsenite-induced genome instability.

  Genome integrity 20100101

• Clioquinol inhibits zinc-triggered caspase activation in the hippocampal CA1 region of a global ischemic gerbil model.

  PloS one 20100101

• Role of nicotinamide in DNA damage, mutagenesis, and DNA repair.

  Journal of nucleic acids 20100101

• Comparative study of the binding characteristics to and inhibitory potencies towards PARP and in vivo antidiabetogenic potencies of taurine, 3-aminobenzamide and nicotinamide.

  Journal of biomedical science 20100101

• PolyADP-ribosylation is required for pronuclear fusion during postfertilization in mice.

  PloS one 20100101

• Targeting the osteosarcoma cancer stem cell.

  Journal of orthopaedic surgery and research 20100101

• Effects of inosine on reperfusion injury after cardiopulmonary bypass.

  Journal of cardiothoracic surgery 20100101

• PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function.

  PloS one 20100101

• BMS-536924 sensitizes human epithelial ovarian cancer cells to the PARP inhibitor, 3-aminobenzamide.

  Gynecologic oncology 20091101

• Inhibition of matrix metalloproteinase-2 by PARP inhibitors.

  Biochemical and biophysical research communications 20091002

• Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway.

  Molecular pharmacology 20091001

• Poly (ADP-Ribose) polymerase inhibition attenuates atherosclerotic plaque development in ApoE-/- mice with hyperhomocysteinemia.

  Journal of atherosclerosis and thrombosis 20091001

• Multiple mechanisms for hydrogen peroxide-induced apoptosis.

  Annals of the New York Academy of Sciences 20090801

• Poly-(ADP-ribose) polymerase-1 is necessary for long-term facilitation in Aplysia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090729

• Effects of 3-aminobenzamide on expressions of poly (ADP ribose) polymerase and apoptosis inducing factor in cardiomyocytes of rats with acute myocardial infarction.

  Chinese medical journal 20090605

• Spatiotemporal activation of caspase-dependent and -independent pathways in staurosporine-induced apoptosis of p53wt and p53mt human cervical carcinoma cells.

  Biology of the cell 20090604

• Apoptosis-inducing factor plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells.

  Apoptosis : an international journal on programmed cell death 20090601

• Roles of inhibitors of poly(ADP-ribose) polymerase in protecting rat RINm5F cell line against free fatty acid-induced apoptosis.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20090601

• Evaluation of poly(ADP-ribose) polymerase cleavage (cPARP) in ejaculated human sperm fractions after induction of apoptosis.

  Fertility and sterility 20090501

• Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment.

  Journal of cellular physiology 20090501

• Diabetic cardiomyopathy.

  Clinical science (London, England : 1979) 20090501

• Poly (ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by hyperhomocysteinemia in rats.

  Cardiovascular drugs and therapy 20090401

• Inhibition of poly(ADP-ribose) polymerase-1 by arsenite interferes with repair of oxidative DNA damage.

  The Journal of biological chemistry 20090313

• Determination of Poly (ADP-ribose) polymerase (PARP) homologues in human ejaculated sperm and its correlation with sperm maturation.

  Fertility and sterility 20090301

• Does the 3-aminobenzamide effect on bacterial translocation affect experimental acute necrotizing pancreatitis?

  The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 20090301

• Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.

  Journal of medicinal chemistry 20090212

• PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPAR gamma in cardiac fibroblasts.

  Cardiovascular research 20090101

• Structure-activity relationship analysis of cytotoxic cyanoguanidines: selection of CHS 828 as candidate drug.

  BMC research notes 20090101

• Recent advances in systemic therapy. When HER2 is not the target: advances in the treatment of HER2-negative metastatic breast cancer.

  Breast cancer research : BCR 20090101

• Poly[ADP-ribose] polymerase-1 expression is related to cold ischemia, acute tubular necrosis, and delayed renal function in kidney transplantation.

  PloS one 20090101

• 3-aminobenzamide, a poly ADP ribose polymerase inhibitor, attenuates renal ischemia/reperfusion injury.

  Renal failure 20090101

• Microglial involvement in neuroplastic changes following focal brain ischemia in rats.

  PloS one 20090101

• Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes.

  Reproductive biology and endocrinology : RB&E 20090101

• Systemic administration of lipopolysaccharide impairs glutathione redox state and object recognition in male mice. The effect of PARP-1 inhibitor.

  Folia neuropathologica 20090101

• Transcriptional regulation of mouse mu opioid receptor gene in neuronal cells by poly(ADP-ribose) polymerase-1.

  Journal of cellular and molecular medicine 20081201

• Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity.

  Toxicology and applied pharmacology 20081001

• The nucleosome-remodeling ATPase ISWI is regulated by poly-ADP-ribosylation.

  PLoS biology 20081001

• Meta-iodobenzylguanidine, an inhibitor of arginine-dependent mono(ADP-ribosyl)ation, prevents neointimal hyperplasia.

  The Journal of pharmacology and experimental therapeutics 20080901

• PARP mediates structural alterations in diabetic cardiomyopathy.

  Journal of molecular and cellular cardiology 20080901

• CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery.

  The Journal of biological chemistry 20080808

• Ischemic and peroxynitrite preconditioning effects in chronic hypoxic rat lung.

  Experimental lung research 20080801

• Effect of 3-amino benzamide, a poly(adenosine diphosphate-ribose) polymerase inhibitor, in experimental caustic esophageal burn.

  Journal of pediatric surgery 20080801

• Inhibition of poly(ADP-ribose) polymerase (PARP) influences the mode of sulfur mustard (SM)-induced cell death in HaCaT cells.

  Archives of toxicology 20080701

• Non-enzymatic fast repair of DNA oxidative damage might also exist in cells.

  Cell biology international 20080601

• Oxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complications.

  Canadian journal of physiology and pharmacology 20080601

• Induction of cytogenetic adaptive response in spermatogonia and spermatocytes by pre-exposure of mouse testis to low-dose (12)C(6+) ions.

  Mutation research 20080531

• Poly(adp-ribose) polymerase-1 regulates Tracp gene promoter activity during RANKL-induced osteoclastogenesis.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20080401

• 1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages.

  Archivum immunologiae et therapiae experimentalis 20080401

• TcPARP: A DNA damage-dependent poly(ADP-ribose) polymerase from Trypanosoma cruzi.

  International journal for parasitology 20080301

• Effects of poly(ADP-ribose) polymerase inhibition in bladder damage caused by cyclophosphamide in rats.

  Experimental biology and medicine (Maywood, N.J.) 20080301

• Combinatorial-approached neuroprotection using pan-caspase inhibitor and poly (ADP-ribose) polymerase (PARP) inhibitor following experimental stroke in rats; is there additional benefit?

  Brain research 20080221

• PARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetes.

  Diabetes/metabolism research and reviews 20080101

• Possible involvement of 12-lipoxygenase activation in glucose-deprivation/reload-treated neurons.

  Neuroscience letters 20071218

• Flavone as PARP-1 inhibitor: its effect on lipopolysaccharide induced gene-expression.

  European journal of pharmacology 20071114

• Activation of telomerase by ionizing radiation: differential response to the inhibition of DNA double-strand break repair by abrogation of poly (ADP-ribosyl)ation, by LY294002, or by Wortmannin.

  International journal of radiation oncology, biology, physics 20071101

• Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells.

  The Journal of nutrition 20071001

• Strain-dependent induction of epithelial cell oncosis by Campylobacter jejuni is correlated with invasion ability and is independent of cytolethal distending toxin.

  Microbiology (Reading, England) 20070901

• Poly(ADP-ribose) polymerase inhibitor is neuroprotective in epileptic rat via apoptosis-inducing factor and Akt signaling.

  Neuroreport 20070806

• 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces oxidative stress, DNA strand breaks, and poly(ADP-ribose) polymerase-1 activation in human breast carcinoma cell lines.

  Toxicology letters 20070801

• Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation.

  Neuroscience 20070713

• Xanthomonas caspase displays an inherent PARP-like activity.

  FEMS microbiology letters 20070701

• Retrodifferentiation and rejuvenation of senescent monocytic cells requires PARP-1.

  Experimental gerontology 20070601

• Enhanced poly(ADP-ribose) polymerase-1 activation contributes to recombinant tissue plasminogen activator-induced aggravation of ischemic brain injury in vivo.

  Journal of neuroscience research 20070601

• Apoptosis in sulfur mustard treated A549 cell cultures.

  Life sciences 20070530

• Combination therapy of poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide and gemcitabine shows strong antitumor activity in pancreatic cancer cells.

  Journal of gastroenterology and hepatology 20070501

• Ischemia/reperfusion of the liver induces heart injury in rats.

  Transplantation proceedings 20070501

• Oxidative stress-induced poly(ADP-ribosyl)ation in chick limb bud-derived chondrocytes.

  International journal of molecular medicine 20070401

• PPAR alpha agonists improve renal preservation in kidneys subjected to chronic in vitro perfusion: interaction with mannitol.

  Transplant international : official journal of the European Society for Organ Transplantation 20070301

• The involvement of ATP produced via (ADP-Ribose)n in the maintenance of DNA replication apparatus during DNA repair.

  Biological & pharmaceutical bulletin 20070301

• Poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide rescues N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in Sprague-Dawley rats through preservation of nuclear factor-kappaB activity.

  Experimental eye research 20070201

• Lactate down-regulates cellular poly(ADP-ribose) formation in cultured human skin fibroblasts.

  European journal of clinical investigation 20070201

• Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells.

  BMC genomics 20070101

• Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition.

  BMC molecular biology 20070101

• Poly(ADP-ribose) polymerase offers protection against oxidative and alkylation damage to the nuclear and mitochondrial genomes of the retinal pigment epithelium.

  Ophthalmic research 20070101

• A general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose.

  Theoretical biology & medical modelling 20070101

• Inhibition of Poly(ADP-ribose)polymerase impairs Epstein Barr Virus lytic cycle progression.

  Infectious agents and cancer 20070101

• [The influence of chemical inhibitors of DNA repair on the recovery of mammalian cell damages induced by ionizing radiation].

  Radiatsionnaia biologiia, radioecologiia 20070101

• PARP inhibitors accelerate N-methyl-N-nitrosourea-induced cataractogenesis in Sprague-Dawley rats.

  In vivo (Athens, Greece) 20070101

• GSK-3beta and oxidative stress in aged brain. Role of poly(ADP- -ribose) polymerase-1.

  Folia neuropathologica 20070101

• [Poly(ADP-ribosa)polymerase--the relationships with life span and carcinogenesis].

  Advances in gerontology = Uspekhi gerontologii 20070101

• Effects of poly(ADP-ribose) polymerase inhibition on dysfunction of non-adrenergic non-cholinergic neurotransmission in gastric fundus in diabetic rats.

  Nitric oxide : biology and chemistry 20061201

• Poly(ADP-ribose) polymerase-1 inhibition protects the brain against systemic inflammation.

  Neurochemistry international 20061201

• Poly(ADP-ribose)polymerase inhibition decreases angiogenesis.

  Biochemical and biophysical research communications 20061201

• Molecular determinants involved in the increase of damage-induced apoptosis and delay of secondary necrosis due to inhibition of mono(ADP-ribosyl)ation.

  Annals of the New York Academy of Sciences 20061201

• Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis.

  Biochemical and biophysical research communications 20061117

• Effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase, in a mouse model of acute pancreatitis induced by cerulein.

  European journal of pharmacology 20061107

• Inhibition of poly(ADP-ribose)polymerase does not affect the recombination events in CHO xrs6 and wild type cells.

  Radiation and environmental biophysics 20061101

• Preconditioning effects of peroxynitrite in the rat lung.

  Pharmacological research 20061101

• Helicobacter pylori induces mono-(adenosine 5'-diphosphate)-ribosylation in human gastric adenocarcinoma.

  International journal of oncology 20061001

• Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents.

  European journal of medical research 20060830

• In vivo exposure of swiss albino mice to chronic low dose of dimethylnitrosamine (DMN) lowers poly-ADP-ribosylation (PAR) of bone marrow cell and blood lymphocyte proteins.

  Molecular and cellular biochemistry 20060801

• Discovery and characterization of triaminotriazine aniline amides as highly selective p38 kinase inhibitors.

  The Journal of pharmacology and experimental therapeutics 20060801

• Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway.

  American journal of physiology. Renal physiology 20060701

• Hydrogen peroxide-mediated necrosis induction in HUVECs is associated with an atypical pattern of caspase-3 cleavage.

  Experimental cell research 20060610

• Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options.

  Gastroenterology 20060601

• Regulation of apoptosis/necrosis execution in cadmium-treated human promonocytic cells under different forms of oxidative stress.

  Apoptosis : an international journal on programmed cell death 20060501

• Ex vivo modulation of response to prednisolone in childhood acute lymphoblastic leukaemia.

  British journal of haematology 20060501

• The effects of tempol, 3-aminobenzamide and nitric oxide synthase inhibitors on acoustic injury of the mouse cochlea.

  Hearing research 20060401

• Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid.

  American journal of physiology. Heart and circulatory physiology 20060401

• IGF-I-induced VEGF expression in HUVEC involves phosphorylation and inhibition of poly(ADP-ribose)polymerase.

  Biochemical and biophysical research communications 20060303

• MafA expression and insulin promoter activity are induced by nicotinamide and related compounds in INS-1 pancreatic beta-cells.

  Diabetes 20060301

• Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20060301

• The telomeric PARP, tankyrases, as targets for cancer therapy.

  British journal of cancer 20060213

• Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure.

  International journal of molecular medicine 20060201

• Inhibition of poly(adp-ribose) polymerase reduces cardiomyocytic apoptosis after global cardiac arrest under cardiopulmonary bypass.

  Shock (Augusta, Ga.) 20060201

• Effect of 3-aminobenzamide on Bcl-2, Bax and AIF localization in hippocampal neurons altered by ischemia-reperfusion injury. the immunocytochemical study.

  Acta neurobiologiae experimentalis 20060101

• Poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide enhances apoptosis induction by platinum complexes in cisplatin-resistant tumor cells.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20060101

• The inhibition and treatment of breast cancer with poly (ADP-ribose) polymerase (PARP-1) inhibitors.

  International journal of biological sciences 20060101

• Flow-cytometric assessment of cellular poly(ADP-ribosyl)ation capacity in peripheral blood lymphocytes.

  Immunity & ageing : I & A 20060101

• PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers?

  International journal of medical sciences 20060101

• Poly (ADP-ribose) polymerase (PARP) is essential for sulfur mustard-induced DNA damage repair, but has no role in DNA ligase activation.

  Journal of applied toxicology : JAT 20060101

• Inhibition of poly (ADP-ribose) polymerase as a protective effect of nicaraven in ionizing radiation- and ara-C-induced cell death.

  Anticancer research 20060101

• A weakened transcriptional enhancer yields variegated gene expression.

  PloS one 20060101

• Poly(ADP-ribose)polymerase activation mediates lung epithelial cell death in vitro but is not essential in hyperoxia-induced lung injury.

  American journal of respiratory cell and molecular biology 20051201

• Inhibition of poly (ADP-ribose) synthetase improves pulmonary arterial endothelium-dependent relaxation after ischemic-reperfusion injury of splanchnic artery in rats.

  Anesthesia and analgesia 20051201

• Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited.

  Diabetes 20051201

• Role of mitogen-activated protein kinases in hydrogen peroxide-induced cell death in osteoblastic cells.

  Toxicology 20051105

• Biodistribution and pharmacokinetics of the (19)F-labeled radiosensitizer 3-aminobenzamide: assessment by (19)F MR imaging.

  Magnetic resonance imaging 20051101

• Effect of 3-aminobenzamide, PARP inhibitor, on matrix metalloproteinase-9 level in plasma and brain of ischemic stroke model.

  Toxicology 20051015

• Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury.

  Laboratory investigation; a journal of technical methods and pathology 20051001

• BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency.

  Cancer biology & therapy 20050901

• Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.

  Journal of medicinal chemistry 20050811

• Cigarette smoke extract induces DNA damage but not apoptosis in human bronchial epithelial cells.

  American journal of respiratory cell and molecular biology 20050801

• Cerebral endothelial cell apoptosis after ischemia-reperfusion: role of PARP activation and AIF translocation.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20050701

• 3-aminobenzamide prevents restraint-evoked immunocompromise.

  Brain, behavior, and immunity 20050701

• Absence of specific cell killing of the BRCA2-deficient human cancer cell line CAPAN1 by poly(ADP-ribose) polymerase inhibition.

  Cancer biology & therapy 20050701

• Poly (adp-ribose) synthetase inhibition reduces oxidative and nitrosative organ damage after thermal injury.

  Pediatric surgery international 20050601

• Effect of poly(ADP-ribosyl)ation inhibitors on the genotoxic effects of the boron neutron capture reaction.

  Mutation research 20050502

• Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury.

  The Journal of pharmacology and experimental therapeutics 20050501

• Inhibition of poly(ADP-ribose) polymerase attenuates lung tissue damage after hind limb ischemia-reperfusion in rats.

  Pharmacological research 20050501

• Poly(ADP-ribose) polymerase-1 could facilitate the religation of topoisomerase I-linked DNA inhibited by camptothecin.

  Cancer research 20050501

• Cigarette smoke condensate induces MMP-12 gene expression in airway-like epithelia.

  Biochemical and biophysical research communications 20050429

• Beneficial effects of PJ34 and INO-1001, two novel water-soluble poly(ADP-ribose) polymerase inhibitors, on the consequences of traumatic brain injury in rat.

  Brain research 20050418

• Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts.

  The FEBS journal 20050401

• The role of poly (adenosine 5'-diphosphate-ribose) polymerase in the response of pituitary tumor cells to reactive oxygen species.

  Endocrinology 20050301

• Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice.

  Toxicological sciences : an official journal of the Society of Toxicology 20050301

• Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene.

  American journal of human genetics 20050301

• Mechanism of ricin-induced apoptosis in human cervical cancer cells.

  Biochemical pharmacology 20050301

• Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration.

  Shock (Augusta, Ga.) 20050301

• Non A beta component of Alzheimer's disease amyloid and amyloid beta peptides evoked poly(ADP-ribose) polymerase-dependent release of apoptosis-inducing factor from rat brain mitochondria.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20050301

• Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma.

  The Journal of pharmacology and experimental therapeutics 20050201

• Disulfide bond mutagenesis and the structure and function of the head-to-tail macrocyclic trypsin inhibitor SFTI-1.

  Biochemistry 20050201

• Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells.

  FEBS letters 20050131

• Modulation of DNMT1 activity by ADP-ribose polymers.

  Oncogene 20050106

• FGF2-mediated upregulation of urokinase-type plasminogen activator expression requires a MAP-kinase dependent activation of poly(ADP-ribose) polymerase.

  Journal of cellular physiology 20050101

• Apoptosis inhibition plays a greater role than necrosis inhibition in decreasing bacterial translocation in experimental intestinal transplantation.

  Surgery 20050101

• Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte.

  Arthritis research & therapy 20050101

• Poly(ADP-ribosyl)ation and epigenetics. Is CTCF PARt of the plot?

  Cell cycle (Georgetown, Tex.) 20050101

• Negative correlation between poly-ADP-ribosylation of spleen cell histone proteins and initial duration of dimethylnitrosamine exposure to mice in vivo measured by Western blot immunoprobe assay: a possible biomarker for cancer detection.

  Cancer detection and prevention 20050101

• Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice.

  Respiratory research 20050101

• Inhibition of poly(ADP-ribose) polymerase activity protects hippocampal cells against morphological and ultrastructural alteration evoked by ischemia-reperfusion injury.

  Folia neuropathologica 20050101

• MIBG, an inhibitor of arginine-dependent mono(ADP-ribosyl)ation, prevents differentiation of L6 skeletal myoblasts by inhibiting expression of myogenin and p21(cip1).

  Experimental cell research 20041210

• Inhibition of poly(ADP-ribose) polymerase prevents allergen-induced asthma-like reaction in sensitized Guinea pigs.

  The Journal of pharmacology and experimental therapeutics 20041201

• The role of poly(ADP-ribose) synthetase inhibition on the intestinal mucosal barrier after thermal injury.

  Burns : journal of the International Society for Burn Injuries 20041201

• 5-Aminoisoquinolinone reduces colon injury by experimental colitis.

  Naunyn-Schmiedeberg's archives of pharmacology 20041201

• Effects of poly(ADP-ribose) polymerase inhibitor on NMDA-induced retinal injury.

  Current eye research 20041201

• Neuronal trauma model: in search of Thanatos.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20041101

• Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.

  Journal of medicinal chemistry 20041021

• Colloidal gold particles as a new in vivo marker of early acute lung injury.

  American journal of physiology. Lung cellular and molecular physiology 20041001

• Poly(ADP-ribose) polymerase inhibition prevents homocysteine-induced endothelial dysfunction in the isolated rat aorta.

  Pharmacology 20041001

• Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation.

  Nature genetics 20041001

• Caspase-1 and poly (ADP-ribose) polymerase inhibitors may protect against peroxynitrite-induced neurotoxicity independent of their enzyme inhibitor activity.

  The European journal of neuroscience 20041001

• Effects of inhibition of poly(adenosine diphosphate-ribose) synthase on acute cardiac allograft rejection.

  Transplantation 20040915

• Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and improves spatial memory of rats with twice-repeated cerebral ischemia.

  Life sciences 20040903

• A new poly(ADP-ribose) polymerase inhibitor, FR261529 [2-(4-chlorophenyl)-5-quinoxalinecarboxamide], ameliorates methamphetamine-induced dopaminergic neurotoxicity in mice.

  The Journal of pharmacology and experimental therapeutics 20040901

• The effect of PARP inhibitor on ischaemic cell death, its related inflammation and survival signals.

  The European journal of neuroscience 20040901

• Poly(ADP-ribose) polymerase activity contributes to peroxynitrite-induced spinal cord neuronal cell death in vitro.

  Journal of neurotrauma 20040901

• Effects 3-aminobenzamide on ultrastructure of hippocampal CA1 layer after global ischemia in gerbils.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040901

• Dual regulation of AP-2alpha transcriptional activation by poly(ADP-ribose) polymerase-1.

  The Biochemical journal 20040815

• Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.

  Science (New York, N.Y.) 20040813

• Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase.

  Journal of medicinal chemistry 20040812

• A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia.

  The Journal of pharmacology and experimental therapeutics 20040801

• Prevention of myocardial reperfusion injury by poly(ADP-ribose) synthetase inhibitor, 3-aminobenzamide, in cardioplegic solution: in vitro study of isolated rat heart model.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20040801

• Pharmacological inhibition of DNA repair enzymes differentially modulates telomerase activity and apoptosis in two human leukaemia cell lines.

  International journal of radiation biology 20040801

• Role of PARP on iNOS pathway during endotoxin-induced acute lung injury.

  Intensive care medicine 20040701

• Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression.

  International journal of molecular medicine 20040701

• Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats.

  British journal of pharmacology 20040701

• Differential DNA double strand break fixation dependence on poly(ADP-ribosylation) in L5178Y and CHO cells.

  International journal of radiation biology 20040701

• Long-term memory requires polyADP-ribosylation.

  Science (New York, N.Y.) 20040618

• Effect of DNA repair inhibitor (3-aminobenzamide) on genetic stability of loach (Misgurnus fossilis) embryos derived from cryopreserved sperm.

  Theriogenology 20040601

• Purification and properties of poly(ADP-ribose)polymerase from Crithidia fasciculata. Automodification and poly(ADP-ribosyl)ation of DNA topoisomerase I.

  Molecular and biochemical parasitology 20040601

• TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex.

  Nature genetics 20040601

• Dual role for poly(ADP-ribose)polymerase-1 and -2 and poly(ADP-ribose)glycohydrolase as DNA-repair and pro-apoptotic factors in rat germinal cells exposed to nitric oxide donors.

  Biochimica et biophysica acta 20040528

• Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors.

  Bioorganic & medicinal chemistry letters 20040517

• Platelet-endothelial cell interaction in pulmonary micro-circulation: the role of PARS.

  Thrombosis and haemostasis 20040401

• Inhibition of poly(adenosine diphosphate-ribose) polymerase decreases long-term histologic damage in testicular ischemia-reperfusion injury.

  Urology 20040401

• Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy.

  Diabetes 20040301

• Caspase inhibition switches the mode of cell death induced by cyanide by enhancing reactive oxygen species generation and PARP-1 activation.

  Toxicology and applied pharmacology 20040301

• Effect of poly(ADP-ribose) polymerase inhibitors on oxidative stress evoked hydroxyl radical level and macromolecules oxidation in cell free system of rat brain cortex.

  Neuroscience letters 20040206

• PARP-1, PARP-2, and the cellular response to low doses of ionizing radiation.

  International journal of radiation oncology, biology, physics 20040201

• Modulation of ATP levels alters the mode of hydrogen peroxide-induced cell death in primary cortical cultures: effects of putative neuroprotective agents.

  Brain research 20040130

• The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).

  Bioorganic & medicinal chemistry letters 20040105

• Neuroprotective effect of combination of poly (ADP-ribose) polymerase inhibitor and antioxidant in middle cerebral artery occlusion induced focal ischemia in rats.

  Neurological research 20040101

• Essential role for poly (ADP-ribosyl)ation in mouse preimplantation development.

  BMC molecular biology 20040101

• Mechanisms of suppression of neoplastic transformation in vitro by low doses of low LET radiation.

  Carcinogenesis 20031201

• The effect of 3-aminobenzamide, inhibitor of poly(ADP-ribose) polymerase, on human osteosarcoma cells.

  International journal of oncology 20031201

• Inhibition of poly(ADP-RIBOSE) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species.

  Free radical biology & medicine 20031201

• 3-Aminobenzamide reduces brain infarction and neutrophil infiltration after transient focal cerebral ischemia in mice.

  Experimental neurology 20031201

• Cytosolic and endoplasmic reticulum Ca2+ concentrations determine the extent and the morphological type of apoptosis, respectively.

  Annals of the New York Academy of Sciences 20031201

• Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20031119

• Role of poly(ADP-ribose) synthetase in pulmonary leukocyte recruitment.

  American journal of physiology. Lung cellular and molecular physiology 20031101

• Deleterious activation of poly(ADP-ribose)polymerase-1 in brain after in vivo oxidative stress.

  Free radical research 20031101

• Deleterious poly(ADP-ribose)polymerase-1 pathway activation in traumatic brain injury in rat.

  Brain research 20031031

• Poly ADP-ribose polymerase (PARP) inhibitors transiently protect leukemia cells from alkylating agent induced cell death by three different effects.

  European journal of medical research 20031022

• Role of poly(ADP-ribose)polymerase in cisplatin-induced injury in LLC-PK1 cells.

  Free radical biology & medicine 20031015

• Integrin-mediated suppression of endotoxin-induced DNA damage in lung endothelial cells is sensitive to poly(ADP-ribose) polymerase-1 gene deletion.

  International journal of molecular medicine 20031001

• Cellular events involved in butyric acid-induced T cell apoptosis.

  Journal of immunology (Baltimore, Md. : 1950) 20031001

• Activation of poly(adenosine diphosphate-ribose) polymerase in mouse tumors treated by photodynamic therapy.

  Photochemistry and photobiology 20031001

• Recombinant IFN-alpha2b treatment activates poly (ADPR) polymerase-1 (PARP-1) in KB cancer cells.

  European journal of cancer (Oxford, England : 1990) 20030901

• The effect of PARS inhibition on ileal histopathology, apoptosis and lipid peroxidation in LPS-induced obstructive jaundice.

  Pharmacological research 20030801

• Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030801

• The selection between apoptosis and necrosis is differentially regulated in hydrogen peroxide-treated and glutathione-depleted human promonocytic cells.

  Cell death and differentiation 20030801

• Involvement of poly(ADP-ribose) synthetase in acoustic trauma of the cochlea.

  The Tohoku journal of experimental medicine 20030801

• Possible role of nicaraven in neuroprotective effect on hippocampal slice culture.

  Canadian journal of physiology and pharmacology 20030701

• Hydrogen peroxide induces association between glyceraldehyde 3-phosphate dehydrogenase and phospholipase D2 to facilitate phospholipase D2 activation in PC12 cells.

  Journal of neurochemistry 20030601

• Hsp70 attenuates hypoxia/reoxygenation-induced activation of poly(ADP-ribose) synthetase in the nucleus of adult rat cardiomyocytes.

  Molecular and cellular biochemistry 20030601

• Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis.

  European journal of pharmacology 20030523

• Distribution of Poly(ADP-ribosyl)ation and cell death after cerebral ischemia in the neonatal rat.

  Pediatric research 20030501

• The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.

  The Journal of urology 20030501

• Apoptosis in leukemia cells is accompanied by alterations in the levels and localization of nucleolin.

  The Journal of biological chemistry 20030307

• Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma.

  American journal of respiratory cell and molecular biology 20030301

• Beneficial effects of poly (ADP-ribose) polymerase inhibition against the reperfusion injury in heart transplantation.

  Free radical research 20030301

• gamma-Irradiation-induced DNA damage enhances NO production via NF-kappaB activation in RAW264.7 cells.

  Biochimica et biophysica acta 20030217

• Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase.

  Critical care medicine 20030201

• Poly(ADP-ribose) polymerase during reperfusion after transient forebrain ischemia: its role in brain edema and cell death.

  Journal of molecular neuroscience : MN 20030201

• Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activation.

  Glia 20030115

• Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor.

  Molecular pharmacology 20030101

• Nicotinamide- and caspase-mediated inhibition of poly(ADP-ribose) polymerase are associated with p53-independent cell cycle (G2) arrest and apoptosis.

  Molecular and cellular biochemistry 20030101

• Oxidant-induced cell death in renal epithelial cells: differential effects of inorganic and organic hydroperoxides.

  Pharmacology & toxicology 20030101

• Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery.

  BMC cell biology 20030101

• Effect of poly(ADP-ribose) polymerase inhibition on outer medullary hypoxic damage.

  Nephron. Physiology 20030101

• Inhibition of neuronal nitric oxide synthase-mediated activation of poly(ADP-ribose) polymerase in traumatic brain injury: neuroprotection by 3-aminobenzamide.

  Neuroscience 20030101

• Modulation of the activation of extracellular signal-regulated kinase (ERK) and the production of inflammatory mediators by ADP-ribosylation inhibitors.

  Biological chemistry 20030101

• Oxidative stress, cell death, and other damage to alveolar epithelial cells induced by cigarette smoke.

  Tobacco induced diseases 20030101

• Structures of Ser205 mutant plasmepsin II from Plasmodium falciparum at 1.8 A in complex with the inhibitors rs367 and rs370.

  Acta crystallographica. Section D, Biological crystallography 20021201

• Oxidant-induced cell death in respiratory epithelial cells is due to DNA damage and loss of ATP.

  Experimental lung research 20021201

• Role of tight junction derangement in the endothelial dysfunction elicited by exogenous and endogenous peroxynitrite and poly(ADP-ribose) synthetase.

  Shock (Augusta, Ga.) 20021101

• The effect of H2O2 and tertiary butyl hydroperoxide upon a murine immortal lens epithelial cell line, alphaTN4-1.

  Experimental eye research 20021101

• Enhanced recovery of radiation-induced translocations from spermatogonial stem cells of p53 null mice.

  Mutation research 20021031

• Differential gene expression in gamma-irradiated BALB/3T3 fibroblasts under the influence of 3-aminobenzamide, an inhibitior of parp enzyme.

  Mutation research 20021031

• Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells.

  Glia 20021001

• The mechanisms of peroxynitrite-induced relaxations in isolated rat anococcygeus muscle.

  Pharmacology 20020901

• Inhibition of poly(ADP-ribosyl)ation induces DNA hypermethylation: a possible molecular mechanism.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020801

• The role of poly(ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis.

  Pharmacological research 20020801

• Nitric oxide induces caspase-dependent apoptosis and necrosis in neonatal rat cardiomyocytes.

  Journal of molecular and cellular cardiology 20020801

• Apoptosis inhibitors delay the cytopathic effect of bovine viral diarrhoea virus (BVDV).

  Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20020801

• Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells.

  Toxicology and applied pharmacology 20020715

• Poly(ADP-ribose) polymerase inhibition prevents both apoptotic-like delayed neuronal death and necrosis after H(2)O(2) injury.

  Journal of neurochemistry 20020701

• tej defines a role for poly(ADP-ribosyl)ation in establishing period length of the arabidopsis circadian oscillator.

  Developmental cell 20020701

• Poly(Adp-ribose) synthetase inhibition prevents lipopolysaccharide-induced peroxynitrite mediated damage in diaphragm.

  Pharmacological research 20020701

• The inhibition of poly(ADP-ribose) polymerase enhances growth rates of ataxia telangiectasia cells.

  Archives of biochemistry and biophysics 20020615

• Liposomal NAD(+) prevents diminished O(2) consumption by immunostimulated Caco-2 cells.

  American journal of physiology. Lung cellular and molecular physiology 20020501

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Roles of oxidative stress and glutathione depletion in JP-8 jet fuel-induced apoptosis in rat lung epithelial cells.

  Toxicology and applied pharmacology 20020415

• Modulation of pyridyl cyanoguanidine (CHS 828) induced cytotoxicity by 3-aminobenzamide in U-937 GTB cells.

  Biochemical pharmacology 20020415

• DNA ligase I null mouse cells show normal DNA repair activity but altered DNA replication and reduced genome stability.

  Journal of cell science 20020401

• Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition.

  The Journal of biological chemistry 20020322

• Protective effects of poly (ADP-ribose) synthase inhibitors on digoxin-induced cardiotoxicity in guinea-pig isolated hearts.

  Pharmacological research 20020301

• Apoptotic and genotoxic effects of a methyl sulfonate ester that selectively generates N3-methyladenine and poly(ADP-ribose) polymerase inhibitors in normal peripheral blood lymphocytes.

  Cancer chemotherapy and pharmacology 20020301

• [Modification of repair DNA synthesis in mutagen-treated human fibroblasts during adaptive response and the antimutagenic effect of garlic extract].

  Genetika 20020301

• [Comparison of the protective effect of garlic extract and cell defense during adaptive response].

  Genetika 20020301

• Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside.

  Cell death and differentiation 20020201

• X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance.

  Cancer research 20020115

• Sensitivity of HaCat keratinocytes to diabetogenic toxins.

  Biochemical pharmacology 20020115

• Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue.

  Carcinogenesis 20020101

• Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020101

• Bench-to-bedside review: Cytopathic hypoxia.

  Critical care (London, England) 20020101

• Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors.

  Journal of pharmacological and toxicological methods 20020101

• Partial protection by poly(ADP-ribose) polymerase inhibitors from nitroxyl-induced cytotoxity in thymocytes.

  Free radical biology & medicine 20011215

• The sequence-specific DNA binding of NF-kappa B is reversibly regulated by the automodification reaction of poly (ADP-ribose) polymerase 1.

  The Journal of biological chemistry 20011214

• Impairment of the neuronal dopamine transporter activity in MPP(+)-treated rat was not prevented by treatments with nitric oxide synthase or poly(ADP-ribose) polymerase inhibitors.

  Neuroscience letters 20011113

• Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase in an amplification phase of tumor necrosis factor-induced apoptosis.

  The Journal of biological chemistry 20011012

• Long-term neuroprotective effect of inhibiting poly(ADP-ribose) polymerase in rats with middle cerebral artery occlusion using a behavioral assessment.

  Brain research 20011012

• Proteasomal degradation of oxidatively damaged endogenous histones in K562 human leukemic cells.

  Free radical biology & medicine 20011001

• Different effects of tert-butylhydroperoxide-induced peroxynitrite-dependent and -independent DNA single-strand breakage on PC12 cell poly(ADP-ribose) polymerase activity.

  European journal of biochemistry 20011001

• TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression.

  The Journal of biological chemistry 20010921

• Activation of poly(ADP-ribose) polymerase in severe hemorrhagic shock and resuscitation.

  American journal of physiology. Gastrointestinal and liver physiology 20010801

• Histone H3 phosphorylation is coupled to poly-(ADP-ribosylation) during reactive oxygen species-induced cell death in renal proximal tubular epithelial cells.

  Molecular pharmacology 20010801

• Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long-term morphological and functional consequences.

  British journal of pharmacology 20010801

• Does the activation of poly (ADP-ribose) synthetase mediate tissue injury in the sepsis induced by cecal ligation and puncture?

  Shock (Augusta, Ga.) 20010801

• Poly(adp-ribose) synthetase inhibition reduces bacterial translocation in rats after endotoxin challenge.

  Shock (Augusta, Ga.) 20010801

• Increased expression and activation of poly(ADP-ribose) polymerase (PARP) contribute to retinal ganglion cell death following rat optic nerve transection.

  Cell death and differentiation 20010801

• Cell density-dependent death mode switch of cultured cortical neurons under serum-free starvation stress.

  Cellular and molecular neurobiology 20010801

• Role of zinc in pulmonary endothelial cell response to oxidative stress.

  American journal of physiology. Lung cellular and molecular physiology 20010701

• Characterization of poly(ADP-ribose)polymerase from Crithidia fasciculata: enzyme inhibition by beta-lapachone.

  Molecular and biochemical parasitology 20010701

• Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity.

  The Journal of investigative dermatology 20010701

• Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system.

  Molecular pharmacology 20010601

• 3-Aminobenzamide, a poly (ADP-ribose) synthetase inhibitor, attenuates the acute inflammatory responses and brain injury in experimental Escherichia coli meningitis in the newborn piglet.

  Neurological research 20010601

• Myocardial ischemic preconditioning in rodents is dependent on poly (ADP-ribose) synthetase.

  Molecular medicine (Cambridge, Mass.) 20010601

• Regulation of the nuclear proteasome activity in myelomonocytic human leukemia cells after adriamycin treatment.

  Blood 20010501

• Suppression of the radiation-sensitive phenotype of hamster irs1 and irs2 strains selected for resistance to 3-aminobenzamide.

  International journal of radiation biology 20010501

• Effects of single or split exposure of leukemic cells to temozolomide, combined with poly(ADP-ribose) polymerase inhibitors on cell growth, chromosomal aberrations and base excision repair components.

  Cancer chemotherapy and pharmacology 20010401

• H2O2-induced cell death in human glioma cells: role of lipid peroxidation and PARP activation.

  Neurochemical research 20010401

• A role for poly(ADP-ribose) polymerase in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene expression.

  The Journal of biological chemistry 20010323

• Role of cell cycle control in radiosensitization of mouse spermatogonial stem cells.

  International journal of radiation biology 20010301

• Rat germinal cells require PARP for repair of DNA damage induced by gamma-irradiation and H2O2 treatment.

  European journal of cell biology 20010301

• Poly(adenosine diphosphate-ribose) synthetase inhibitor 3-aminobenzamide alleviates cochlear dysfunction induced by transient ischemia.

  The Annals of otology, rhinology, and laryngology 20010201

• Regulation of BK(Ca) channels expressed in human embryonic kidney 293 cells by epoxyeicosatrienoic acid.

  Molecular pharmacology 20010101

• Regulation of bleomycin-induced DNA breakage and chromatin structure in lung endothelial cells by integrins and poly(ADP-ribose) polymerase.

  Molecular pharmacology 20010101

• Inhibition of poly(ADP-ribose) polymerase attenuates cerebral vasospasm after subarachnoid hemorrhage in rabbits.

  Stroke 20010101

• The role of nitric oxide in diaphragmatic dysfunction in endotoxemic rats.

  Muscle & nerve 20010101

• Excessive base excision repair of 5-hydroxymethyluracil from DNA induces apoptosis in Chinese hamster V79 cells containing mutant p53.

  Carcinogenesis 20010101

• Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells.

  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20010101

• [Neuronal death: potential role of the nuclear enzyme, poly (ADP-ribose) polymerase].

  Bulletin de l'Academie nationale de medecine 20010101

• Poly(ADP-ribose) polymerase-1 regulates the stability of the wild-type p53 protein.

  Cellular & molecular biology letters 20010101

• Inhibition of poly(ADP-ribose) polymerase attenuates ischemic renal injury in rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20001101

• All trans retinoic acid induces apoptosis in acute promyelocytic NB4 cells when combined with isoquinolinediol, a poly(ADP-ribose) polymerase inhibitor.

  Leukemia research 20000401

• N-methyl-D-aspartate (NMDA)--induced apoptosis in rat retina.

  Investigative ophthalmology & visual science 19990901

• Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins.

  Journal of medicinal chemistry 19980423

• Specific induction of the hsr omega locus of Drosophila melanogaster by amides.

  Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 19970901

• Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.

  Annals of tropical medicine and parasitology 19961201

• Nitric oxide is a mediator of methamphetamine (METH)-induced neurotoxicity. In vitro evidence from primary cultures of mesencephalic cells.

  Annals of the New York Academy of Sciences 19961031

• Neuroprotection against nitric oxide injury with inhibitors of ADP-ribosylation.

  Neuroreport 19931213

• Effect of tumour promoters on poly ADP-ribosylation in human epidermoid carcinoma HeP2 cells.

  International journal of experimental pathology 19901201

• A comparative study on the effect of tumor promoters on poly ADP-ribosylation in A431 cells.

  International journal of cancer 19901015

• Enhancement of DEN initiation of liver carcinogenesis by inhibitors of NAD+ ADP ribosyl transferase in rats.

  Carcinogenesis 19840701