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Lysophosphatidic acid alters the expression profiles of angiogenic factors, cytokines, and chemokines in mouse liver sinusoidal endothelial cells.
PloS one 20150101
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Effects of lysophosphatidic acid on calpain-mediated proteolysis of focal adhesion kinase in human prostate cancer cells.
The Prostate 20121101
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Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts.
Journal of medicinal chemistry 20120913
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Effect of inhibition of the lysophosphatidic acid receptor 1 on metastasis and metastatic dormancy in breast cancer.
Journal of the National Cancer Institute 20120905
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Selective non-lipid modulator of LPA5 activity in human platelets.
Bioorganic & medicinal chemistry letters 20120815
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Synthesis and biological evaluation of optically active Ki16425.
Bioorganic & medicinal chemistry letters 20120701
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Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity.
Molecules and cells 20120227
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Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing.
Journal of Alzheimer's disease : JAD 20120101
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Lysophosphatidic acid induces erythropoiesis through activating lysophosphatidic acid receptor 3.
Stem cells (Dayton, Ohio) 20111101
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Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs.
American journal of physiology. Lung cellular and molecular physiology 20111001
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TNF-α potentiates lysophosphatidic acid-induced COX-2 expression via PKD in human colonic myofibroblasts.
American journal of physiology. Gastrointestinal and liver physiology 20110401
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Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells.
Journal of bone and mineral metabolism 20101101
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Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100526
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Synthesis, in vitro structure-activity relationship, and in vivo studies of 2-arylthiazolidine-4-carboxylic acid amides as anticancer agents.
Bioorganic & medicinal chemistry 20100115
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Regulation of cerebromicrovascular permeability by lysophosphatidic acid.
Microcirculation (New York, N.Y. : 1994) 20100101
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Lysophosphatidic acid stimulates prostaglandin E2 production in cultured stromal endometrial cells through LPA1 receptor.
Experimental biology and medicine (Maywood, N.J.) 20090801
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Lysophosphatidic Acid signals through specific lysophosphatidic Acid receptor subtypes to control key regenerative responses of human gingival and periodontal ligament fibroblasts.
Journal of periodontology 20090801
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Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist.
Journal of neurochemistry 20090401
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LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites.
Carcinogenesis 20090301
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Lysophosphatic acid modulates prostaglandin secretion in the bovine uterus.
Reproduction (Cambridge, England) 20090101
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Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: distinct roles for Gi- and Rho-dependent pathways.
Pharmacology 20090101
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Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells.
Journal of immunology (Baltimore, Md. : 1950) 20081001
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Lysophosphatidylserine stimulates chemotactic migration in U87 human glioma cells.
Biochemical and biophysical research communications 20080912
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Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2.
Cancer science 20080801
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Lysophosphatidylglycerol stimulates chemotactic migration in human natural killer cells.
Biochemical and biophysical research communications 20080718
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Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC.
The Journal of biological chemistry 20080613
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Identification of non-lipid LPA3 antagonists by virtual screening.
Bioorganic & medicinal chemistry 20080601
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Dioleoyl phosphatidic acid induces morphological changes through an endogenous LPA receptor in C6 glioma cells.
Archives of pharmacal research 20080501
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Bacteria induce CTGF and CYR61 expression in epithelial cells in a lysophosphatidic acid receptor-dependent manner.
International journal of medical microbiology : IJMM 20080401
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Lysophosphatidic acid-stimulated interleukin-6 and -8 synthesis through LPA1 receptors on human osteoblasts.
Archives of oral biology 20080301
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Lysophosphatidylserine induces calcium signaling through Ki16425/VPC32183-sensitive GPCR in bone marrow-derived mast cells and in C6 glioma and colon cancer cells.
Archives of pharmacal research 20080301
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Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake.
Journal of molecular medicine (Berlin, Germany) 20080201
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LPA1 receptor activation promotes renal interstitial fibrosis.
Journal of the American Society of Nephrology : JASN 20071201
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Lysophosphatidylglycerol stimulates chemotactic migration and tube formation in human umbilical vein endothelial cells.
Biochemical and biophysical research communications 20071123
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The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor.
Biochemical and biophysical research communications 20071123
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Activatory properties of lysophosphatidic acid on human THP-1 cells.
Inflammation 20071001
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Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists.
Bioorganic & medicinal chemistry letters 20070701
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Dioleoyl phosphatidic acid increases intracellular Ca2+ through endogenous LPA receptors in C6 glioma and L2071 fibroblasts.
Prostaglandins & other lipid mediators 20070601
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LPA2 (EDG4) mediates Rho-dependent chemotaxis with lower efficacy than LPA1 (EDG2) in breast carcinoma cells.
American journal of physiology. Cell physiology 20070501
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Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-G(i/o) pathway.
Neurochemistry international 20070101
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Lysophosphatidic acid as a mediator for proinflammatory agonists in a human corneal epithelial cell line.
American journal of physiology. Cell physiology 20061101
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Protean agonism of the lysophosphatidic acid receptor-1 with Ki16425 reduces nerve growth factor-induced neurite outgrowth in pheochromocytoma 12 cells.
Journal of neurochemistry 20060901
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Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells.
The Biochemical journal 20060815
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Lysophosphatidic acid induces chemotaxis in MC3T3-E1 osteoblastic cells.
Bone 20060701
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Lysophosphatidic acid cooperates with 1alpha,25(OH)2D3 in stimulating human MG63 osteoblast maturation.
Prostaglandins & other lipid mediators 20060701
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The basic secretagogue compound 48/80 activates G proteins indirectly via stimulation of phospholipase D-lysophosphatidic acid receptor axis and 5-HT1A receptors in rat brain sections.
British journal of pharmacology 20060301
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Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer.
Cancer research 20060301
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Lysophosphatidic acid (LPA)-induced vascular endothelial growth factor (VEGF) by mesothelial cells and quantification of host-derived VEGF in malignant ascites.
The Journal of surgical research 20060101
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Activatory properties of lysophosphatidic acid on human THP-1 cells.
Inflammation 20051201
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Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
Journal of medicinal chemistry 20050728
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Identification of autotaxin as a neurite retraction-inducing factor of PC12 cells in cerebrospinal fluid and its possible sources.
Journal of neurochemistry 20050201
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Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.
The Journal of biological chemistry 20040423
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Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.
The Journal of biological chemistry 20040220
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Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors.
Molecular pharmacology 20031001
