360-97-4 | 4-Amino-5-imidazolecarboxamide

Packsize	Purity	Availability	Price	Discounted Price
5g	97%	in stock	$7.00	$5.00
25g	97%	in stock	$15.00	$11.00
500g	97%	in stock	$276.00	$193.00

Description

• Catalog Number: AB45202
• Chemical Name: 4-Amino-5-imidazolecarboxamide
• CAS Number: 360-97-4
• Molecular Formula: C4H6N4O
• Molecular Weight: 126.1166
• MDL Number: MFCD02181040
• SMILES: NC(=O)c1[nH]cnc1N
• NSC Number: 7784

Computed Properties

• Complexity: 126
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 1
• XLogP3: -0.5

Literature

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• Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction.

  Bioorganic & medicinal chemistry 20131001

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• Combination therapy with 5-amino-4-imidazolecarboxamide riboside and arsenic trioxide in acute myeloid leukemia cells involving AMPK/TSC2/mTOR pathway.

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  Science (New York, N.Y.) 20121123

• AMP-activated kinase relaxes agonist induced contractions in the mouse aorta via effects on PKC signaling and inhibits NO-induced relaxation.

  European journal of pharmacology 20121115

• Impact of glucagon-like peptide-1 (7-36) amide, isosteviol and 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside on leucine-mediated α-cell dysfunction.

  Diabetes, obesity & metabolism 20121101

• Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes.

  Journal of lipid research 20121101

• Palmitate causes endoplasmic reticulum stress and apoptosis in human mesenchymal stem cells: prevention by AMPK activator.

  Endocrinology 20121101

• AMP-activated protein kinase stimulates myostatin expression in C2C12 cells.

  Biochemical and biophysical research communications 20121012

• AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway.

  Melanoma research 20121001

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  Plant science : an international journal of experimental plant biology 20121001

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  Journal of muscle research and cell motility 20121001

• AMP-activated protein kinase upregulates glucose uptake in thyroid PCCL3 cells independent of thyrotropin.

  Thyroid : official journal of the American Thyroid Association 20121001

• Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation.

  American journal of physiology. Gastrointestinal and liver physiology 20120915

• Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression.

  The Journal of nutritional biochemistry 20120901

• Metformin preconditioning protects Daphnia pulex from lethal hypoxic insult involving AMPK, HIF and mTOR signaling.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20120901

• Activation of AMP-activated protein kinase inhibits the proliferation of human endothelial cells.

  The Journal of pharmacology and experimental therapeutics 20120901

• Platycodin D inhibits lipogenesis through AMPKα-PPARγ2 in 3T3-L1 cells and modulates fat accumulation in obese mice.

  Planta medica 20120901

• Alterations of phosphoproteins in NCI-H526 small cell lung cancer cells involved in cytotoxicity of cisplatin and titanocene Y.

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• Structural and biochemical characterization of human adenylosuccinate lyase (ADSL) and the R303C ADSL deficiency-associated mutation.

  Biochemistry 20120821

• The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism.

  American journal of physiology. Endocrinology and metabolism 20120815

• Phosphorylation of adipose triglyceride lipase Ser(404) is not related to 5'-AMPK activation during moderate-intensity exercise in humans.

  American journal of physiology. Endocrinology and metabolism 20120815

• Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphate.

  Molecular pharmacology 20120801

• Adiponectin inhibits KISS1 gene transcription through AMPK and specificity protein-1 in the hypothalamic GT1-7 neurons.

  The Journal of endocrinology 20120801

• AMPK activation by AICAR inhibits myogenic differentiation and myostatin expression in cattle.

  Cell and tissue research 20120801

• Effect of adenosine-regulating agent acadesine on morbidity and mortality associated with coronary artery bypass grafting: the RED-CABG randomized controlled trial.

  JAMA 20120711

• Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells.

  The Journal of biological chemistry 20120706

• AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney.

  British journal of pharmacology 20120701

• Intracellular disposition of methotrexate in acute lymphoblastic leukemia in children.

  Current drug metabolism 20120701

• Targeting the liver kinase B1/AMP-activated protein kinase pathway as a therapeutic strategy for hematological malignancies.

  Expert opinion on therapeutic targets 20120701

• Epinephrine and AICAR-induced PGC-1α mRNA expression is intact in skeletal muscle from rats fed a high-fat diet.

  American journal of physiology. Cell physiology 20120615

• Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells.

  The Journal of biological chemistry 20120608

• Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis.

  Investigative ophthalmology & visual science 20120601

• In mammalian muscle, SIRT3 is present in mitochondria and not in the nucleus; and SIRT3 is upregulated by chronic muscle contraction in an adenosine monophosphate-activated protein kinase-independent manner.

  Metabolism: clinical and experimental 20120501

• PDGF-induced airway smooth muscle proliferation is associated with Human antigen R activation and could be weakened by AMPK activation.

  Molecular biology reports 20120501

• Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle.

  American journal of physiology. Endocrinology and metabolism 20120501

• Suppression of adipose lipolysis by long-chain fatty acid analogs.

  Journal of lipid research 20120501

• A novel method to measure glucose uptake and myosin heavy chain isoform expression of single fibers from rat skeletal muscle.

  Diabetes 20120501

• AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterol.

  Endocrinology 20120501

• Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism.

  Mechanisms of ageing and development 20120501

• Accessible high-throughput virtual screening molecular docking software for students and educators.

  PLoS computational biology 20120501

• AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes.

  Circulation research 20120427

• Determination of famoxadone, fenamidone, fenhexamid and iprodione residues in greenhouse tomatoes.

  Pest management science 20120401

• Vinorelbine-induced oxidative injury in human endothelial cells mediated by AMPK/PKC/NADPH/NF-κB pathways.

  Cell biochemistry and biophysics 20120401

• Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι.

  Metabolism: clinical and experimental 20120401

• AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase.

  The Biochemical journal 20120401

• AMP-activated protein kinase activator AICAR acutely lowers blood pressure and relaxes isolated resistance arteries of hypertensive rats.

  Journal of hypertension 20120401

• Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling.

  Cancer prevention research (Philadelphia, Pa.) 20120401

• Cilostazol Decreases Ethanol-Mediated TNFalpha Expression in RAW264.7 Murine Macrophage and in Liver from Binge Drinking Mice.

  The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20120401

• Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells.

  Biochemical and biophysical research communications 20120323

• Inhibition of AMP-activated protein kinase α (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1.

  The Journal of biological chemistry 20120309

• Angiotensin II reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamus.

  Endocrinology 20120301

• Abstracts of the 6th cachexia conference, milan, Italy, december 8-10, 2011 (part 2).

  Journal of cachexia, sarcopenia and muscle 20120301

• AMP-activated protein kinase connects cellular energy metabolism to KATP channel function.

  Journal of molecular and cellular cardiology 20120201

• Regulation of hepatic lipin-1 by ethanol: role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice.

  Hepatology (Baltimore, Md.) 20120201

• Activation of AMP-kinase by AICAR induces apoptosis of DU-145 prostate cancer cells through generation of reactive oxygen species and activation of c-Jun N-terminal kinase.

  International journal of oncology 20120201

• AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1.

  Journal of cellular biochemistry 20120201

• 5-Aminoimidazole-4-carboxyamide ribonucleoside induces G(1)/S arrest and Nanog downregulation via p53 and enhances erythroid differentiation.

  Stem cells (Dayton, Ohio) 20120201

• Novel synthetic methods for N-cyano-1H-imidazole-4-carboxamides and their fungicidal activity.

  Bioorganic & medicinal chemistry letters 20120201

• AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation.

  Nature medicine 20120201

• Antiproliferative activity of levobupivacaine and aminoimidazole carboxamide ribonucleotide on human cancer cells of variable bioenergetic profile.

  Mitochondrion 20120101

• Post-treatment with the combination of 5-aminoimidazole-4-carboxyamide ribonucleoside and carnitine improves renal function after ischemia/reperfusion injury.

  Shock (Augusta, Ga.) 20120101

• Chronic AMPK stimulation attenuates adaptive signaling in dystrophic skeletal muscle.

  American journal of physiology. Cell physiology 20120101

• Metabolomics of the effect of AMPK activation by AICAR on human umbilical vein endothelial cells.

  International journal of molecular medicine 20120101

• Microarray expression analysis in delayed cardioprotection: the effect of exercise, AICAR, or metformin and the possible role of AMP-activated protein kinase (AMPK).

  Molecular and cellular biochemistry 20120101

• AMP-activated protein kinase mediates effects of oxidative stress on embryo gene expression in a mouse model of diabetic embryopathy.

  Diabetologia 20120101

• Adiponectin self-regulates its expression and multimerization in adipose tissue: an autocrine/paracrine mechanism?

  Medical hypotheses 20120101

• AMP-activated protein kinase and the control of smooth muscle cell hyperproliferation in vascular disease.

  Vascular pharmacology 20120101

• 3,5-Disubstituted-thiazolidine-2,4-dione analogs as anticancer agents: design, synthesis and biological characterization.

  European journal of medicinal chemistry 20120101

• Short-term effects of combined iprodione and vermicompost applications on soil microbial community structure.

  The Science of the total environment 20120101

• Monitoring metabolites consumption and secretion in cultured cells using ultra-performance liquid chromatography quadrupole-time of flight mass spectrometry (UPLC-Q-ToF-MS).

  Analytical and bioanalytical chemistry 20120101

• Anticancer properties of pomolic acid-induced AMP-activated protein kinase activation in MCF7 human breast cancer cells.

  Biological & pharmaceutical bulletin 20120101

• Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis.

  PloS one 20120101

• HCMV targets the metabolic stress response through activation of AMPK whose activity is important for viral replication.

  PLoS pathogens 20120101

• Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells.

  PloS one 20120101

• Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production.

  PloS one 20120101

• Intracerebroventricular administration of metformin inhibits ghrelin-induced Hypothalamic AMP-kinase signalling and food intake.

  Neuroendocrinology 20120101

• Glucose enhances leptin signaling through modulation of AMPK activity.

  PloS one 20120101

• Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice.

  PloS one 20120101

• 5'-AMP Activated Protein Kinase is Involved in the Regulation of Myocardial β-Oxidative Capacity in Mice.

  Frontiers in physiology 20120101

• Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma.

  Frontiers in genetics 20120101

• Analyzing microarray data of Alzheimer's using cluster analysis to identify the biomarker genes.

  International journal of Alzheimer's disease 20120101

• Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes.

  PloS one 20120101

• ALK Signaling and Target Therapy in Anaplastic Large Cell Lymphoma.

  Frontiers in oncology 20120101

• Alternative strategy for Alzheimer's disease: stress response triggers.

  International journal of Alzheimer's disease 20120101

• Efficiency of purine utilization by Helicobacter pylori: roles for adenosine deaminase and a NupC homolog.

  PloS one 20120101

• Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes.

  Journal of nutrition and metabolism 20120101

• MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor.

  PloS one 20120101

• Proliferating effect of orotic acid through mTORC1 activation mediated by negative regulation of AMPK in SK-Hep1 hepatocellular carcinoma cells.

  The Journal of toxicological sciences 20120101

• Functional and structural comparison of pyrrolnitrin- and iprodione-induced modifications in the class III histidine-kinase Bos1 of Botrytis cinerea.

  PloS one 20120101

• A low thermal mass fast gas chromatograph and its implementation in fast gas chromatography mass spectrometry with supersonic molecular beams.

  Journal of chromatography. A 20111230

• 5'-AMP-activated protein kinase (AMPK) regulates progesterone receptor transcriptional activity in breast cancer cells.

  Biochemical and biophysical research communications 20111209

• Antileukemic effects of AMPK activators on BCR-ABL-expressing cells.

  Blood 20111208

• Stimulation of cardiomyogenesis of embryonic stem cells by nitric oxide downstream of AMP-activated protein kinase and mTOR signaling pathways.

  Stem cells and development 20111201

• Alternative splice variant PGC-1α-b is strongly induced by exercise in human skeletal muscle.

  American journal of physiology. Endocrinology and metabolism 20111201

• 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein kinase-independent.

  The Journal of pharmacology and experimental therapeutics 20111201

• Pharmacological AMP-kinase activators have compartment-specific effects on cell physiology.

  American journal of physiology. Cell physiology 20111201

• AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300.

  Arteriosclerosis, thrombosis, and vascular biology 20111201

• 5-aminoimidazole-4-carboxamide riboside enhances effect of ionizing radiation in PC3 prostate cancer cells.

  International journal of radiation oncology, biology, physics 20111201

• A novel cardioprotective agent in cardiac transplantation: metformin activation of AMP-activated protein kinase decreases acute ischemia-reperfusion injury and chronic rejection.

  The Yale journal of biology and medicine 20111201

• AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells.

  The International journal of artificial organs 20111201

• Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide.

  The Journal of biological chemistry 20111125

• Roles of AMP-activated protein kinase in diabetes-induced retinal inflammation.

  Investigative ophthalmology & visual science 20111125

• Adiponectin promotes hyaluronan synthesis along with increases in hyaluronan synthase 2 transcripts through an AMP-activated protein kinase/peroxisome proliferator-activated receptor-α-dependent pathway in human dermal fibroblasts.

  Biochemical and biophysical research communications 20111118

• AICAR reverses ketone body mediated insulin resistance in isolated oxidative muscle.

  Biochemical and biophysical research communications 20111104

• Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries.

  Clinical science (London, England : 1979) 20111101

• Role of the energy sensor adenosine monophosphate-activated protein kinase in the regulation of immature gonadotropin-releasing hormone neuron migration.

  Journal of endocrinological investigation 20111101

• Inhibition of hepatitis C virus replication through adenosine monophosphate-activated protein kinase-dependent and -independent pathways.

  Microbiology and immunology 20111101

• Central AMP-activated protein kinase affects sympathetic nerve activity in rats.

  Neuroscience letters 20111010

• Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle.

  The Journal of biological chemistry 20111007

• Intravenous AICAR during hyperinsulinemia induces systemic hemodynamic changes but has no local metabolic effect.

  Journal of clinical pharmacology 20111001

• AMP-activated protein kinase plays a role in initiating metabolic rate suppression in goldfish hepatocytes.

  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20111001

• Activated AMPK inhibits PPAR-{alpha} and PPAR-{gamma} transcriptional activity in hepatoma cells.

  American journal of physiology. Gastrointestinal and liver physiology 20111001

• The influence of the BRAF V600E mutation in thyroid cancer cell lines on the anticancer effects of 5-aminoimidazole-4-carboxamide-ribonucleoside.

  The Journal of endocrinology 20111001

• Defective myofibroblast formation from mesenchymal stem cells in the aging murine heart rescue by activation of the AMPK pathway.

  The American journal of pathology 20111001

• Angiotensin II upregulates protein phosphatase 2Cα and inhibits AMP-activated protein kinase signaling and energy balance leading to skeletal muscle wasting.

  Hypertension (Dallas, Tex. : 1979) 20111001

• Transcriptome-wide binding sites for components of the Saccharomyces cerevisiae non-poly(A) termination pathway: Nrd1, Nab3, and Sen1.

  PLoS genetics 20111001

• Activation of the metabolic sensor-AMP activated protein kinase reverses impairment of angiogenesis in aging myocardial microvascular endothelial cells. Implications for the aging heart.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20111001

• Solid-phase synthesis of a new diphosphate 5-aminoimidazole-4-carboxamide riboside (AICAR) derivative and studies toward cyclic AICAR diphosphate ribose.

  Molecules (Basel, Switzerland) 20110921

• Multiresidue method for the determination of 13 pesticides in three environmental matrices: water, sediments and fish muscle.

  Talanta 20110915

• Physiological and toxic effects of purine intermediate 5-amino-4-imidazolecarboxamide ribonucleotide (AICAR) in yeast.

  The Journal of biological chemistry 20110902

• AMP-activated protein kinase regulates normal rat somatotroph cell function and growth of rat pituitary adenomatous cells.

  Pituitary 20110901

• Dynamic alteration of adiponectin/adiponectin receptor expression and its impact on myocardial ischemia/reperfusion in type 1 diabetic mice.

  American journal of physiology. Endocrinology and metabolism 20110901

• Chronic AMPK activation evokes the slow, oxidative myogenic program and triggers beneficial adaptations in mdx mouse skeletal muscle.

  Human molecular genetics 20110901

• purL gene expression affects biofilm formation and symbiotic persistence of Photorhabdus temperata in the nematode Heterorhabditis bacteriophora.

  Microbiology (Reading, England) 20110901

• Reductions in RIP140 are not required for exercise- and AICAR-mediated increases in skeletal muscle mitochondrial content.

  Journal of applied physiology (Bethesda, Md. : 1985) 20110901

• Chronic AMP-kinase activation with AICAR reduces adiposity by remodeling adipocyte metabolism and increasing leptin sensitivity.

  Journal of lipid research 20110901

• Inhibitory effect of aminoimidazole carboxamide ribonucleotide (AICAR) on endotoxin-induced uveitis in rats.

  Investigative ophthalmology & visual science 20110822

• Structure-activity relationship studies of novel pyrazole and imidazole carboxamides as cannabinoid-1 (CB1) antagonists.

  Bioorganic & medicinal chemistry letters 20110815

• Antagonistic control of muscle cell size by AMPK and mTORC1.

  Cell cycle (Georgetown, Tex.) 20110815

• Deficiency of insulin-like growth factor 1 reduces vulnerability to chronic alcohol intake-induced cardiomyocyte mechanical dysfunction: role of AMPK.

  Journal of cellular and molecular medicine 20110801

• Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis.

  Annals of the rheumatic diseases 20110801

• AICAR and Compound C regulate food intake independently of AMP-activated protein kinase in lines of chickens selected for high or low body weight.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20110801

• Mice lacking TR4 nuclear receptor develop mitochondrial myopathy with deficiency in complex I.

  Molecular endocrinology (Baltimore, Md.) 20110801

• Acute therapeutic use of 5-aminoimidazole-4-carboxamide ribonucleoside extends survival interval in response to severe hemorrhagic shock.

  Shock (Augusta, Ga.) 20110801

• Globular adiponectin protects human umbilical vein endothelial cells against apoptosis through adiponectin receptor 1/adenosine monophosphate-activated protein kinase pathway.

  Chinese medical journal 20110801

• Chalkbrood transmission in the alfalfa leafcutting bee: the impact of disinfecting bee cocoons in loose cell management systems.

  Environmental entomology 20110801

• AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats.

  Neuroscience letters 20110725

• In vivo correction of COX deficiency by activation of the AMPK/PGC-1α axis.

  Cell metabolism 20110706

• Pharmacokinetic results of a phase I trial of sorafenib in combination with dacarbazine in patients with advanced solid tumors.

  Cancer chemotherapy and pharmacology 20110701

• Anti-inflammatory effects of thiazolidinediones in human airway smooth muscle cells.

  American journal of respiratory cell and molecular biology 20110701

• Down-regulation of the ubiquitin-proteasome proteolysis system by amino acids and insulin involves the adenosine monophosphate-activated protein kinase and mammalian target of rapamycin pathways in rat hepatocytes.

  Amino acids 20110701

• Functional analysis of the 5' flanking region of the human G6PC3 gene: regulation of promoter activity by glucose, pyruvate, AMP kinase and the pentose phosphate pathway.

  Molecular genetics and metabolism 20110701

• AICAR, an activator of AMPK, inhibits adipogenesis via the WNT/β-catenin pathway in 3T3-L1 adipocytes.

  International journal of molecular medicine 20110701

• Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell.

  Journal of cellular physiology 20110701

• AMPK activation enhances PPARα activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway.

  Archives of biochemistry and biophysics 20110701

• Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle.

  American journal of physiology. Regulatory, integrative and comparative physiology 20110701

• LKB1/AMPK/mTOR signaling pathway in hematological malignancies: from metabolism to cancer cell biology.

  Cell cycle (Georgetown, Tex.) 20110701

• Chronic high cytosolic calcium decreases AICAR-induced AMPK activity via calcium/calmodulin activated protein kinase II signaling cascade.

  Cell calcium 20110701

• Na,K-ATPase activity in mouse muscle is regulated by AMPK and PGC-1α.

  The Journal of membrane biology 20110701

• Involvement of a phosphorylation-mediated pathway to regulate the function of NSPL1 in exercise.

  The Journal of veterinary medical science 20110601

• A novel role for AMP-kinase in the regulation of the Na+/I--symporter and iodide uptake in the rat thyroid gland.

  American journal of physiology. Cell physiology 20110601

• AMP-activated protein kinase rescues the angiogenic functions of endothelial progenitor cells via manganese superoxide dismutase induction in type 1 diabetes.

  American journal of physiology. Endocrinology and metabolism 20110601

• α₂-Adrenoceptors activate noradrenaline-mediated glycogen turnover in chick astrocytes.

  Journal of neurochemistry 20110601

• Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling.

  The Journal of clinical investigation 20110601

• AICAR inhibits cancer cell growth and triggers cell-type distinct effects on OXPHOS biogenesis, oxidative stress and Akt activation.

  Biochimica et biophysica acta 20110601

• Beneficial effects of metformin on primary cardiomyocytes via activation of adenosine monophosphate-activated protein kinase.

  Chinese medical journal 20110601

• AICAR induced AMPK activation potentiates neuronal insulin signaling and glucose uptake.

  Archives of biochemistry and biophysics 20110515

• Activation of AMP-activated protein kinase may not be involved in AICAR- and metformin-mediated meiotic arrest in bovine denuded and cumulus-enclosed oocytes in vitro.

  Zygote (Cambridge, England) 20110501

• Increasing tumoral 5-fluorouracil concentrations during a 5-day continuous infusion: a microdialysis study.

  Cancer chemotherapy and pharmacology 20110501

• Mechanism of growth inhibition of intraerythrocytic stages of Plasmodium falciparum by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).

  Molecular and biochemical parasitology 20110501

• Evidence that chromium modulates cellular cholesterol homeostasis and ABCA1 functionality impaired by hyperinsulinemia--brief report.

  Arteriosclerosis, thrombosis, and vascular biology 20110501

• AMPK and substrate availability regulate creatine transport in cultured cardiomyocytes.

  American journal of physiology. Endocrinology and metabolism 20110501

• Chronic activation of AMP-activated protein kinase prevents 20-hydroxyeicosatetraenoic acid-induced endothelial dysfunction.

  Clinical and experimental pharmacology & physiology 20110501

• Glucosensing by GnRH neurons: inhibition by androgens and involvement of AMP-activated protein kinase.

  Molecular endocrinology (Baltimore, Md.) 20110501

• Arecoline-mediated inhibition of AMP-activated protein kinase through reactive oxygen species is required for apoptosis induction.

  Oral oncology 20110501

• Inhibition of the AMP-activated protein kinase-α2 accentuates agonist-induced vascular smooth muscle contraction and high blood pressure in mice.

  Hypertension (Dallas, Tex. : 1979) 20110501

• Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling.

  Nature immunology 20110501

• Trafficking of drug candidates relevant for sports drug testing: detection of non-approved therapeutics categorized as anabolic and gene doping agents in products distributed via the Internet.

  Drug testing and analysis 20110501

• LITAF and TNFSF15, two downstream targets of AMPK, exert inhibitory effects on tumor growth.

  Oncogene 20110421

• Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice.

  FEBS letters 20110420

• AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization.

  Science (New York, N.Y.) 20110408

• Metformin induces Rab4 through AMPK and modulates GLUT4 translocation in skeletal muscle cells.

  Journal of cellular physiology 20110401

• Effect of LKB1 deficiency on mitochondrial content, fibre type and muscle performance in the mouse diaphragm.

  Acta physiologica (Oxford, England) 20110401

• Abnormal metabolism flexibility in response to high palmitate concentrations in myotubes derived from obese type 2 diabetic patients.

  Biochimica et biophysica acta 20110401

• Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway.

  The Journal of pharmacology and experimental therapeutics 20110401

• Isoform-selective 5'-AMP-activated protein kinase-dependent preconditioning mechanisms to prevent postischemic leukocyte-endothelial cell adhesive interactions.

  American journal of physiology. Heart and circulatory physiology 20110401

• Involvement of oxygen-regulated protein 150 in AMP-activated protein kinase-mediated alleviation of lipid-induced endoplasmic reticulum stress.

  The Journal of biological chemistry 20110401

• Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent.

  Journal of lipid research 20110401

• Activation of AMP-kinase by policosanol requires peroxisomal metabolism.

  Lipids 20110401

• One-pot synthesis of 2-amino-indole-3-carboxamide and analogous.

  ACS combinatorial science 20110314

• Leptin controls ketone body utilization in hypothalamic neuron.

  Neuroscience letters 20110303

• Metabolic stress modulates motor patterning via AMP-activated protein kinase.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110302

• Short-term adenosine monophosphate-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside treatment increases the sirtuin 1 protein expression in skeletal muscle.

  Metabolism: clinical and experimental 20110301

• In vitro hybridization and separation of hybrids of human adenylosuccinate lyase from wild-type and disease-associated mutant enzymes.

  Biochemistry 20110301

• AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia.

  Molecular cancer therapeutics 20110301

• Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways.

  Diabetes 20110301

• Molecular mechanism by which AMP-activated protein kinase activation promotes glycogen accumulation in muscle.

  Diabetes 20110301

• Profiling single nucleotide polymorphisms (SNPs) across intracellular folate metabolic pathway in healthy Indians.

  The Indian journal of medical research 20110301

• Identification of aneuploidy-selective antiproliferation compounds.

  Cell 20110218

• Metabolic stress boosts humoral responses in vivo independently of inflammasome and inflammatory reaction.

  Journal of immunology (Baltimore, Md. : 1950) 20110215

• Activation of adenosine-monophosphate-activated protein kinase abolishes desflurane-induced preconditioning against myocardial infarction in vivo.

  Journal of cardiothoracic and vascular anesthesia 20110201

• Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects.

  Journal of inherited metabolic disease 20110201

• Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1α mRNA: a role of β₂-adrenergic receptor activation.

  American journal of physiology. Endocrinology and metabolism 20110201

• Plasticity in the purine-thiamine metabolic network of Salmonella.

  Genetics 20110201

• Metformin improves cardiac function in rats via activation of AMP-activated protein kinase.

  Clinical and experimental pharmacology & physiology 20110201

• Central infusion of leptin does not increase AMPK signaling in skeletal muscle of sheep.

  American journal of physiology. Regulatory, integrative and comparative physiology 20110201

• Inhibition of the heterotetrameric K+ channel KCNQ1/KCNE1 by the AMP-activated protein kinase.

  Molecular membrane biology 20110201

• Endurance factors improve hippocampal neurogenesis and spatial memory in mice.

  Learning & memory (Cold Spring Harbor, N.Y.) 20110201

• AMP-activated protein kinase inhibits homocysteine-induced dysfunction and apoptosis in endothelial progenitor cells.

  Cardiovascular drugs and therapy 20110201

• The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function.

  Diabetes 20110201

• Participation of hindbrain AMP-activated protein kinase in glucoprivic feeding.

  Diabetes 20110201

• Sensitivity of Penicillium expansum field isolates to tebuconazole, iprodione, fludioxonil and cyprodinil and characterization of fitness parameters and patulin production.

  International journal of food microbiology 20110131

• AMP-activated protein kinase (AMPK) positively regulates osteoblast differentiation via induction of Dlx5-dependent Runx2 expression in MC3T3E1 cells.

  Biochemical and biophysical research communications 20110128

• AMP-activated protein kinase regulates the expression of monocarboxylate transporter 4 in skeletal muscle.

  Life sciences 20110117

• Does long-term metformin treatment increase cardiac lipoprotein lipase?

  Metabolism: clinical and experimental 20110101

• Enhancement of extracellular purine nucleoside accumulation by Bacillus strains through genetic modifications of genes involved in nucleoside export.

  Journal of industrial microbiology & biotechnology 20110101

• Cardiac-specific leptin receptor deletion exacerbates ischaemic heart failure in mice.

  Cardiovascular research 20110101

• Endothelium-dependent vasorelaxation to the AMPK activator AICAR is enhanced in aorta from hypertensive rats and is NO and EDCF dependent.

  American journal of physiology. Heart and circulatory physiology 20110101

• Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival.

  American journal of physiology. Heart and circulatory physiology 20110101

• Potential role of adenosine monophosphate-activated protein kinase in regulation of energy metabolism in dairy goat mammary epithelial cells.

  Journal of dairy science 20110101

• Tumor necrosis factor-alpha promotes survival in methotrexate-exposed macrophages by an NF-kappaB-dependent pathway.

  Arthritis research & therapy 20110101

• Adenosine activates AMPK to phosphorylate Bcl-XL responsible for mitochondrial damage and DIABLO release in HuH-7 cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

• Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate.

  Arthritis research & therapy 20110101

• An invertebrate hyperglycemic model for the identification of anti-diabetic drugs.

  PloS one 20110101

• Oral inflammatory myofibroblastic tumor: case report and review of literature.

  The open dentistry journal 20110101

• Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder.

  BMC medical genetics 20110101

• Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription.

  International journal of biological sciences 20110101

• Olanzapine-induced hyperphagia and weight gain associate with orexigenic hypothalamic neuropeptide signaling without concomitant AMPK phosphorylation.

  PloS one 20110101

• Systems biology of bacterial nitrogen fixation: high-throughput technology and its integrative description with constraint-based modeling.

  BMC systems biology 20110101

• The effect of an intracerebroventricular injection of metformin or AICAR on the plasma concentrations of melatonin in the ewe: potential involvement of AMPK?

  BMC neuroscience 20110101

• Shikonin increases glucose uptake in skeletal muscle cells and improves plasma glucose levels in diabetic Goto-Kakizaki rats.

  PloS one 20110101

• Intracellular trafficking as a determinant of AS-DACA cytotoxicity in rhabdomyosarcoma cells.

  BMC cell biology 20110101

• Upstream molecular signaling pathways of p27(Kip1) expression in human breast cancer cells in vitro: differential effects of 4-hydroxytamoxifen and deficiency of either D-(+)-glucose or L-leucine.

  Cancer cell international 20110101

• Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain.

  Molecular pain 20110101

• The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases.

  Mechanisms of ageing and development 20110101

• Screening for active small molecules in mitochondrial complex I deficient patient's fibroblasts, reveals AICAR as the most beneficial compound.

  PloS one 20110101

• Metabolic specialization of mouse embryonic stem cells.

  Cold Spring Harbor symposia on quantitative biology 20110101

• Biological monitoring of pesticide exposures in residents living near agricultural land.

  BMC public health 20110101

• Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study.

  BMC medical genetics 20110101

• Increased FAT/CD36 cycling and lipid accumulation in myotubes derived from obese type 2 diabetic patients.

  PloS one 20110101

• Reconstruction of Purine Metabolism in Bacillus subtilis to Obtain the Strain Producer of AICAR: A New Drug with a Wide Range of Therapeutic Applications.

  Acta naturae 20110101

• Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition.

  Oncogene 20101216

• Adenosine regulates Sertoli cell function by activating AMPK.

  Molecular and cellular endocrinology 20101215

• Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas.

  Cancer research 20101215

• AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis.

  Biochemical pharmacology 20101201

• Genetic downregulation of AMPK-alpha isoforms uncovers the mechanism by which metformin decreases FA uptake and oxidation in skeletal muscle cells.

  American journal of physiology. Cell physiology 20101201

• AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle.

  American journal of physiology. Regulatory, integrative and comparative physiology 20101201

• AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells.

  American journal of physiology. Renal physiology 20101201

• AMPK as a therapeutic target in renal cell carcinoma.

  Cancer biology & therapy 20101201

• AMPK signaling: a targetable tumor suppressor pathway?

  Cancer biology & therapy 20101201

• Chemoselective multicomponent one-pot assembly of purine precursors in water.

  Journal of the American Chemical Society 20101124

• AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.

  The Journal of biological chemistry 20101112

• ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells.

  Biochemical and biophysical research communications 20101112

• AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3).

  Diabetologia 20101101

• Combined in silico and experimental approach for drug design: the binding mode of peptidic and non-peptidic inhibitors to hsp90 N-terminal domain.

  Chemical biology & drug design 20101101

• [Effects of AMPK on the transcriptional activity of FOXO1 and ubiquitin ligase MuRF1 expression in rat cardiomyocytes].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20101101

• Functional phosphoproteomic analysis reveals cold-shock domain protein A to be a Bcr-Abl effector-regulating proliferation and transformation in chronic myeloid leukemia.

  Cell death & disease 20101101

• Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice.

  The Journal of biological chemistry 20101022

• AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.

  Blood 20101021

• AICAR induces cyclooxygenase-2 expression through AMP-activated protein kinase-transforming growth factor-beta-activated kinase 1-p38 mitogen-activated protein kinase signaling pathway.

  Biochemical pharmacology 20101015

• Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle.

  The Biochemical journal 20101015

• 5-aminoimidazole-4-carboxamide ribonucleoside and AMP-activated protein kinase inhibit signalling through NF-κB.

  Immunology and cell biology 20101001

• Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors.

  Molecular pharmacology 20101001

• Melanocortin-4 receptor activation promotes insulin-stimulated mTOR signaling.

  Peptides 20101001

• Hypothalamic AMP-activated protein kinase regulates glucose production.

  Diabetes 20101001

• Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle.

  Diabetes 20101001

• Role of AMPK throughout meiotic maturation in the mouse oocyte: evidence for promotion of polar body formation and suppression of premature activation.

  Molecular reproduction and development 20101001

• Plant-growth regulator, imidazole-4-carboxamide, produced by the fairy ring forming fungus Lepista sordida.

  Journal of agricultural and food chemistry 20100922

• Identification of small molecule compounds with higher binding affinity to guanine deaminase (cypin) than guanine.

  Bioorganic & medicinal chemistry 20100915

• Studies on ligand binding to histidine triad nucleotide binding protein 1.

  Bioorganic & medicinal chemistry 20100915

• AMP-activated protein kinase controls metabolism and heat production during embryonic development in birds.

  The Journal of experimental biology 20100915

• Coordinated maintenance of muscle cell size control by AMP-activated protein kinase.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100901

• {beta}-Hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle.

  American journal of physiology. Endocrinology and metabolism 20100901

• The mitogen-activated protein kinase kinase BOS5 is involved in regulating vegetative differentiation and virulence in Botrytis cinerea.

  Fungal genetics and biology : FG & B 20100901

• PGC-1{alpha} is required for AICAR-induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle.

  American journal of physiology. Endocrinology and metabolism 20100901

• AMPK regulates metabolic actions of glucocorticoids by phosphorylating the glucocorticoid receptor through p38 MAPK.

  Molecular endocrinology (Baltimore, Md.) 20100901

• Rosiglitazone inhibits monocyte/macrophage adhesion through de novo adiponectin production in human monocytes.

  Journal of cellular biochemistry 20100815

• AMP-activated protein kinase mediates activity-dependent regulation of peroxisome proliferator-activated receptor gamma coactivator-1alpha and nuclear respiratory factor 1 expression in rat visual cortical neurons.

  Neuroscience 20100811

• Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100801

• AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass.

  Bone 20100801

• A pharmacological activator of AMP-activated protein kinase protects hypoxic neurons in a concentration-dependent manner.

  Neurochemical research 20100801

• Metabolic preconditioning of cells with AICAR-riboside: improved cryopreservation and cell-type specific impacts on energetics and proliferation.

  Cryobiology 20100801

• Chronic AMP-activated protein kinase activation and a high-fat diet have an additive effect on mitochondria in rat skeletal muscle.

  Journal of applied physiology (Bethesda, Md. : 1985) 20100801

• AMPK enhances the expression of pancreatic duodenal homeobox-1 via PPARalpha, but not PPARgamma, in rat insulinoma cell line INS-1.

  Acta pharmacologica Sinica 20100801

• 5-aminoimidazole-4-carboxamide-1-beta-ribofuranoside (AICAR) prevents nuclear translocation of constitutive androstane receptor by AMP-activated protein kinase (AMPK) independent manner.

  The Journal of toxicological sciences 20100801

• siRNA-mediated AMPKalpha1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells.

  The Journal of toxicological sciences 20100801

• AMP-activated kinase (AMPK)-generated signals in malignant melanoma cell growth and survival.

  Biochemical and biophysical research communications 20100716

• Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction.

  Arteriosclerosis, thrombosis, and vascular biology 20100701

• The apical (hPepT1) and basolateral peptide transport systems of Caco-2 cells are regulated by AMP-activated protein kinase.

  American journal of physiology. Gastrointestinal and liver physiology 20100701

• Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells.

  American journal of physiology. Renal physiology 20100701

• Activation of AMPK inhibits cardiomyocyte hypertrophy by modulating of the FOXO1/MuRF1 signaling pathway in vitro.

  Acta pharmacologica Sinica 20100701

• Analysis and stability study of temozolomide using capillary electrophoresis.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100701

• Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy.

  The Journal of biological chemistry 20100618

• To eat or not to eat: the effect of AICAR on food intake regulation in yellow-bellied marmots (Marmota flaviventris).

  The Journal of experimental biology 20100615

• AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells.

  Biochemical and biophysical research communications 20100604

• AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells.

  American journal of respiratory cell and molecular biology 20100601

• In vivo proton MR spectroscopy findings specific for adenylosuccinate lyase deficiency.

  NMR in biomedicine 20100601

• Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside in the muscle microcirculation increases nitric oxide synthesis and microvascular perfusion.

  Arteriosclerosis, thrombosis, and vascular biology 20100601

• Novel anti-inflammatory action of 5-aminoimidazole-4-carboxamide ribonucleoside with protective effect in dextran sulfate sodium-induced acute and chronic colitis.

  The Journal of pharmacology and experimental therapeutics 20100601

• Stimulators of AMP-activated kinase (AMPK) inhibit seawater- but not cAMP-induced oocyte maturation in a marine worm: Implications for interactions between cAMP and AMPK signaling.

  Molecular reproduction and development 20100601

• In vivo stimulation of AMP-activated protein kinase enhanced tubuloglomerular feedback but reduced tubular sodium transport during high dietary NaCl intake.

  Pflugers Archiv : European journal of physiology 20100601

• Lipid-induced insulin resistance is prevented in lean and obese myotubes by AICAR treatment.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100601

• Anti-growth effect of 1,25-dihydroxyvitamin D3-3-bromoacetate alone or in combination with 5-amino-imidazole-4-carboxamide-1-beta-4-ribofuranoside in pancreatic cancer cells.

  Anticancer research 20100601

• Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway.

  Arteriosclerosis, thrombosis, and vascular biology 20100501

• Differential AMPK phosphorylation sites associated with phenylephrine vs. antihypertrophic effects of adenosine agonists in neonatal rat ventricular myocytes.

  American journal of physiology. Heart and circulatory physiology 20100501

• Probing the cannabinoid CB1/CB2 receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern.

  Bioorganic & medicinal chemistry letters 20100501

• Activation of AMP-activated protein kinase stimulates the nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in human diploid fibroblasts.

  Experimental & molecular medicine 20100430

• AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes.

  Circulation research 20100402

• Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase.

  Diabetologia 20100401

• Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance.

  Diabetes 20100401

• Quantification of urinary AICAR concentrations as a matter of doping controls.

  Analytical and bioanalytical chemistry 20100401

• AICA-riboside (acadesine), an activator of AMP-activated protein kinase with potential for application in hematologic malignancies.

  Expert opinion on investigational drugs 20100401

• GTPase activity plays a key role in the pathobiology of LRRK2.

  PLoS genetics 20100401

• Short-term AMP-regulated protein kinase activation enhances insulin-sensitive fatty acid uptake and increases the effects of insulin on fatty acid oxidation in L6 muscle cells.

  Experimental biology and medicine (Maywood, N.J.) 20100401

• A microarray-based genetic screen for yeast chronological aging factors.

  PLoS genetics 20100401

• Chronic ethanol feeding impairs AMPK and MEF2 expression and is associated with GLUT4 decrease in rat myocardium.

  Experimental & molecular medicine 20100331

• Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation.

  Oncogene 20100318

• Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways.

  Experimental cell research 20100310

• Central role of nitric oxide synthase in AICAR and caffeine-induced mitochondrial biogenesis in L6 myocytes.

  Journal of applied physiology (Bethesda, Md. : 1985) 20100301

• Adenosine 5'-monophosphate-activated protein kinase-mammalian target of rapamycin cross talk regulates brown adipocyte differentiation.

  Endocrinology 20100301

• Cardioprotection with adenosine-regulating agent, GP531: effects on no-reflow, infarct size, and blood flow following ischemia/ reperfusion in the rabbit.

  Journal of cardiovascular pharmacology and therapeutics 20100301

• Long-term ethanol exposure inhibits glucose transporter 4 expression via an AMPK-dependent pathway in adipocytes.

  Acta pharmacologica Sinica 20100301

• Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP.

  The Biochemical journal 20100215

• Quantification of iprodione in dry basil using silica gel supported titanium dioxide.

  Journal of agricultural and food chemistry 20100210

• Structural and functional studies of Aspergillus clavatus N(5)-carboxyaminoimidazole ribonucleotide synthetase .

  Biochemistry 20100202

• Acute exposure to rosiglitazone does not affect glucose transport in intact human skeletal muscle.

  Metabolism: clinical and experimental 20100201

• Involvement of mTOR in globular adiponectin-induced generation of reactive oxygen species.

  Free radical research 20100201

• AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.

  American journal of physiology. Endocrinology and metabolism 20100201

• Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle.

  American journal of physiology. Cell physiology 20100201

• Metformin increases phagocytosis and acidifies lysosomal/endosomal compartments in AMPK-dependent manner in rat primary microglia.

  Naunyn-Schmiedeberg's archives of pharmacology 20100201

• Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction.

  Cardiovascular drugs and therapy 20100201

• Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100101

• Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1beta gene expression in pancreatic islet beta-cells.

  Diabetes 20100101

• AICAR (5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside) increases the production of toxic molecules and affects the profile of cytokines release in LPS-stimulated rat primary microglial cultures.

  Neurotoxicology 20100101

• Suppression effects of AICAR on insulin secretion involved in peroxisome proliferator-activated receptor gamma changes in INS-1 cells.

  Journal of endocrinological investigation 20100101

• Ethanol inhibits gastric acid secretion in rats through increased AMP-kinase activity.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• Metabolic regulation of neuronal plasticity by the energy sensor AMPK.

  PloS one 20100101

• AMPK exerts dual regulatory effects on the PI3K pathway.

  Journal of molecular signaling 20100101

• Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids.

  Cancer cell international 20100101

• Phospholipase D1 mediates AMP-activated protein kinase signaling for glucose uptake.

  PloS one 20100101

• PGC-1alpha down-regulation affects the antioxidant response in Friedreich's ataxia.

  PloS one 20100101

• 5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase.

  Molecular cancer 20100101

• PRAS40 regulates protein synthesis and cell cycle in C2C12 myoblasts.

  Molecular medicine (Cambridge, Mass.) 20100101

• Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner.

  PloS one 20100101

• Oligodendroglia from ADSL-deficient patient produce SAICAribotide and SAMP.

  Molecular genetics and metabolism 20100101

• AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia.

  Journal of molecular signaling 20100101

• MOLA: a bootable, self-configuring system for virtual screening using AutoDock4/Vina on computer clusters.

  Journal of cheminformatics 20100101

• Microsatellite stability in the plant pathogen Botrytis cinerea after exposure to different selective pressures.

  Fungal biology 20100101

• Dockomatic - automated ligand creation and docking.

  BMC research notes 20100101

• Metformin has adenosine-monophosphate activated protein kinase (AMPK)-independent effects on LPS-stimulated rat primary microglial cultures.

  Pharmacological reports : PR 20100101

• Activation of the AMP-activated protein kinase enhances glucose-stimulated insulin secretion in mouse β-cells.

  Islets 20100101

• AMP-activated protein kinase activation during cardioplegia-induced hypoxia/reoxygenation injury attenuates cardiomyocytic apoptosis via reduction of endoplasmic reticulum stress.

  Mediators of inflammation 20100101

• Pathobiology of anaplastic large cell lymphoma.

  Advances in hematology 20100101

• Activation of AMP-activated protein kinase (AMPK) inhibits fatty acid synthesis in bovine mammary epithelial cells.

  Biochemical and biophysical research communications 20091218

• Development of hepatic fibrosis occurs normally in AMPK-deficient mice.

  Clinical science (London, England : 1979) 20091214

• Activation of AMP-activated protein kinase suppresses oxidized low-density lipoprotein-induced macrophage proliferation.

  The Journal of biological chemistry 20091211

• Carbon monoxide (from CORM-2) inhibits high glucose-induced ICAM-1 expression via AMP-activated protein kinase and PPAR-gamma activations in endothelial cells.

  Atherosclerosis 20091201

• The 5' adenosine monophosphate-activated protein kinase: regulating the ebb and flow of cellular energetics.

  The international journal of biochemistry & cell biology 20091201

• Glucose deprivation regulates KATP channel trafficking via AMP-activated protein kinase in pancreatic beta-cells.

  Diabetes 20091201

• Osteoblast differentiation is functionally associated with decreased AMP kinase activity.

  Journal of cellular physiology 20091201

• CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle.

  American journal of physiology. Regulatory, integrative and comparative physiology 20091201

• Adiponectin downregulates galectin-3 whose cellular form is elevated whereas its soluble form is reduced in type 2 diabetic monocytes.

  FEBS letters 20091119

• Anergic T cells are metabolically anergic.

  Journal of immunology (Baltimore, Md. : 1950) 20091115

• Glucose, metformin, and AICAR regulate the expression of G protein-coupled receptor members in INS-1 beta cell.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20091101

• Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity.

  Diabetologia 20091101

• Restoring AS160 phosphorylation rescues skeletal muscle insulin resistance and fatty acid oxidation while not reducing intramuscular lipids.

  American journal of physiology. Endocrinology and metabolism 20091101

• Basal autophagy induction without AMP-activated protein kinase under low glucose conditions.

  Autophagy 20091101

• Toxicity of fungicides with different modes of action to Cladobotryum dendroides and Agaricus bisporus.

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20091101

• AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation.

  Science (New York, N.Y.) 20091016

• Police find range of drugs after trawling bins used by Tour de France cyclists.

  BMJ (Clinical research ed.) 20091013

• C1q tumor necrosis factor alpha-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase.

  The Journal of biological chemistry 20091009

• Metformin promotes induction of lipoprotein lipase in skeletal muscle through activation of adenosine monophosphate-activated protein kinase.

  Metabolism: clinical and experimental 20091001

• Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin.

  Diabetes 20091001

• Chronic activation of 5'-AMP-activated protein kinase changes myosin heavy chain expression in growing pigs.

  Journal of animal science 20091001

• AMP-activated protein kinase enhances the expression of muscle-specific ubiquitin ligases despite its activation of IGF-1/Akt signaling in C2C12 myotubes.

  Journal of cellular biochemistry 20091001

• Genetic impairment of AMPKalpha2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice.

  American journal of physiology. Endocrinology and metabolism 20091001

• The phosphorylation status of membrane-bound nucleoside diphosphate kinase in epithelia and the role of AMP.

  Molecular and cellular biochemistry 20090901

• Fatty acid oxidation and meiotic resumption in mouse oocytes.

  Molecular reproduction and development 20090901

• Cumulative and antagonistic effects of a mixture of the antiandrogens vinclozolin and iprodione in the pubertal male rat.

  Toxicological sciences : an official journal of the Society of Toxicology 20090901

• AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons.

  American journal of physiology. Cell physiology 20090901

• Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside.

  The Journal of endocrinology 20090901

• Intra-arterial AICA-riboside administration induces NO-dependent vasodilation in vivo in human skeletal muscle.

  American journal of physiology. Endocrinology and metabolism 20090901

• Central AMPK contributes to sleep homeostasis in mice.

  Neuropharmacology 20090901

• The structure of phosphate-bound Escherichia coli adenylosuccinate lyase identifies His171 as a catalytic acid.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20090901

• Analysis of pesticide residues by fast gas chromatography in combination with negative chemical ionization mass spectrometry.

  Journal of chromatography. A 20090828

• Eicosapentaenoic acid stimulates AMP-activated protein kinase and increases visfatin secretion in cultured murine adipocytes.

  Clinical science (London, England : 1979) 20090814

• The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis.

  Proceedings of the National Academy of Sciences of the United States of America 20090804

• Adiponectin downregulates CD163 whose cellular and soluble forms are elevated in obesity.

  European journal of clinical investigation 20090801

• AMPK inhibits myoblast differentiation through a PGC-1alpha-dependent mechanism.

  American journal of physiology. Endocrinology and metabolism 20090801

• Role of the atypical protein kinase Czeta in regulation of 5'-AMP-activated protein kinase in cardiac and skeletal muscle.

  American journal of physiology. Endocrinology and metabolism 20090801

• Green tea catechin controls apoptosis in colon cancer cells by attenuation of H2O2-stimulated COX-2 expression via the AMPK signaling pathway at low-dose H2O2.

  Annals of the New York Academy of Sciences 20090801

• Effects of cotreatment of 12-O-tetradecanoylphorbol-13-acetate and H2O2 on apoptotic regulation via AMP-activated protein kinase-cyclooxygenase-2 signals.

  Annals of the New York Academy of Sciences 20090801

• Application of prolonged microdialysis sampling in carboplatin-treated cancer patients.

  Cancer chemotherapy and pharmacology 20090701

• Regulation of visceral and subcutaneous adipocyte lipolysis by acute AICAR-induced AMPK activation.

  Obesity (Silver Spring, Md.) 20090701

• PGC-1alpha mediates exercise-induced skeletal muscle VEGF expression in mice.

  American journal of physiology. Endocrinology and metabolism 20090701

• Regulation and function of proline oxidase under nutrient stress.

  Journal of cellular biochemistry 20090701

• Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation.

  American journal of physiology. Endocrinology and metabolism 20090701

• Effects of AMPK activators on the sub-cellular distribution of fatty acid transporters CD36 and FABPpm.

  Archives of physiology and biochemistry 20090701

• 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases myocardial glucose uptake during reperfusion and induces late pre-conditioning: potential role of AMP-activated protein kinase.

  Basic & clinical pharmacology & toxicology 20090701

• Adiponectin decreases pyruvate dehydrogenase kinase 4 gene expression in obese- and diabetic-derived myotubes.

  Diabetes, obesity & metabolism 20090701

• Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition.

  Cancer research 20090701

• Toward synthesis of the isosteric sulfonate analogues of the AT-III binding domain of heparin.

  Organic letters 20090618

• Anaplastic lymphoma kinase: signalling in development and disease.

  The Biochemical journal 20090615

• Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphate and purine pathways.

  Genes & development 20090615

• Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR).

  Cell biology and toxicology 20090601

• Contractions but not AICAR increase FABPpm content in rat muscle sarcolemma.

  Molecular and cellular biochemistry 20090601

• Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction.

  Journal of molecular and cellular cardiology 20090601

• Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes.

  American journal of physiology. Regulatory, integrative and comparative physiology 20090601

• Serine-385 phosphorylation of inwardly rectifying K+ channel subunit (Kir6.2) by AMP-dependent protein kinase plays a key role in rosiglitazone-induced closure of the K(ATP) channel and insulin secretion in rats.

  Diabetologia 20090601

• AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.

  Biochemical pharmacology 20090601

• Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells.

  Clinical and experimental immunology 20090601

• Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells.

  Neuroscience letters 20090522

• Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase.

  Circulation 20090519

• Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry.

  Journal of medicinal chemistry 20090514

• Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells.

  Oncogene 20090507

• Dorsal hindbrain 5'-adenosine monophosphate-activated protein kinase as an intracellular mediator of energy balance.

  Endocrinology 20090501

• Interleukin-6 attenuates insulin-mediated increases in endothelial cell signaling but augments skeletal muscle insulin action via differential effects on tumor necrosis factor-alpha expression.

  Diabetes 20090501

• A myosin II ATPase inhibitor reduces force production, glucose transport, and phosphorylation of AMPK and TBC1D1 in electrically stimulated rat skeletal muscle.

  American journal of physiology. Endocrinology and metabolism 20090501

• Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status.

  American journal of physiology. Endocrinology and metabolism 20090501

• Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose.

  American journal of physiology. Endocrinology and metabolism 20090501

• AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives.

  Acta physiologica (Oxford, England) 20090501

• AMP-activated protein kinase response to contractions and treatment with the AMPK activator AICAR in young adult and old skeletal muscle.

  The Journal of physiology 20090501

• AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.

  Nature 20090423

• The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis.

  The Journal of physiology 20090415

• Regulation of erythrocyte survival by AMP-activated protein kinase.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090401

• Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL.

  Journal of lipid research 20090401

• Elucidation of the substrate specificity, kinetic and catalytic mechanism of adenylosuccinate lyase from Plasmodium falciparum.

  Biochimica et biophysica acta 20090401

• Resistin acutely impairs insulin-stimulated glucose transport in rodent muscle in the presence, but not absence, of palmitate.

  American journal of physiology. Regulatory, integrative and comparative physiology 20090401

• AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells.

  American journal of physiology. Cell physiology 20090401

• AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease.

  Clinical science (London, England : 1979) 20090401

• AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells.

  Journal of cellular and molecular medicine 20090401

• [Genetic control of metabolism of mutagenic purine base analogs 6-hydroxylaminopurine and 2-amino-6-hydroxylaminopurine in yeast Saccharomyces cerevisiae].

  Genetika 20090401

• The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL.

  Blood 20090319

• [Doping in the next generation: wringing extra performance from the genotype].

  MMW Fortschritte der Medizin 20090319

• AMP-activated protein kinase is involved in neural stem cell growth suppression and cell cycle arrest by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and glucose deprivation by down-regulating phospho-retinoblastoma protein and cyclin D.

  The Journal of biological chemistry 20090306

• Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090304

• Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha.

  American journal of respiratory cell and molecular biology 20090301

• Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090301

• Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes.

  Biochimica et biophysica acta 20090301

• Exercise: it's the real thing!

  Nutrition reviews 20090301

• Adiponectin inhibits insulin-like growth factor-1-induced cell migration by the suppression of extracellular signal-regulated kinase 1/2 activation, but not Akt in vascular smooth muscle cells.

  Hypertension research : official journal of the Japanese Society of Hypertension 20090301

• Mechanistic insight into control of CFTR by AMPK.

  The Journal of biological chemistry 20090227

• AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633.

  Circulation research 20090227

• Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells.

  Biochemical and biophysical research communications 20090227

• Kinase activity-independent suppression of p73alpha by AMP-activated kinase alpha (AMPKalpha).

  Oncogene 20090219

• Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle.

  Endocrinology 20090201

• Outcomes of methotrexate therapy for psoriasis and relationship to genetic polymorphisms.

  The British journal of dermatology 20090201

• Inhibition of the KCa3.1 channels by AMP-activated protein kinase in human airway epithelial cells.

  American journal of physiology. Cell physiology 20090201

• AICAR preconditioning prevents postischemic leukocyte rolling and adhesion: role of K(ATP) channels and heme oxygenase.

  Microcirculation (New York, N.Y. : 1994) 20090201

• A new constitutively active mutant of AMP-activated protein kinase inhibits anoxia-induced apoptosis of vascular endothelial cell.

  Hypertension research : official journal of the Japanese Society of Hypertension 20090201

• 2-Deoxy-d-glucose protects neural progenitor cells against oxidative stress through the activation of AMP-activated protein kinase.

  Neuroscience letters 20090116

• AMPK-sensed cellular energy state regulates the release of extracellular Fatty Acid Synthase.

  Biochemical and biophysical research communications 20090116

• Interrogating the mechanism of a tight binding inhibitor of AIR carboxylase.

  Bioorganic & medicinal chemistry 20090115

• The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor.

  Cell metabolism 20090107

• C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.

  The Journal of biological chemistry 20090102

• Involvement of AMP-activated protein kinase and p38 mitogen-activated protein kinase in 8-Cl-cAMP-induced growth inhibition.

  Journal of cellular physiology 20090101

• Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators.

  IUBMB life 20090101

• Misleading behavioural phenotype with adenylosuccinate lyase deficiency.

  European journal of human genetics : EJHG 20090101

• Alpha2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise.

  American journal of physiology. Endocrinology and metabolism 20090101

• Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 myoblasts.

  Endocrine journal 20090101

• Chronic elevated calcium blocks AMPK-induced GLUT-4 expression in skeletal muscle.

  American journal of physiology. Cell physiology 20090101

• Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression.

  American journal of physiology. Endocrinology and metabolism 20090101

• Interactions between ROS and AMP kinase activity in the regulation of PGC-1alpha transcription in skeletal muscle cells.

  American journal of physiology. Cell physiology 20090101

• AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts.

  BMC pharmacology 20090101

• Inhibition of cervical cancer cell growth through activation of upstream kinases of AMP-activated protein kinase.

  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20090101

• Strong dietary restrictions protect Drosophila against anoxia/reoxygenation injuries.

  PloS one 20090101

• Genomic characterization of methanomicrobiales reveals three classes of methanogens.

  PloS one 20090101

• Modulation of O(2) sensitive K (+) channels by AMP-activated protein kinase.

  Advances in experimental medicine and biology 20090101

• Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase.

  PloS one 20090101

• Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death.

  PloS one 20090101

• Effects of angiotensin II receptor blockade on glucose metabolism via AMP-activated protein kinase in insulin-resistant hypertensive rats.

  Journal of the American Society of Hypertension : JASH 20090101

• Temozolomide: The evidence for its therapeutic efficacy in malignant astrocytomas.

  Core evidence 20090101

• Critical appraisal of temozolomide formulations in the treatment of primary brain tumors: patient considerations.

  Cancer management and research 20090101

• Structural analysis of the active site geometry of N5-carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli.

  Biochemistry 20081216

• AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise.

  The Journal of physiology 20081215

• Parallel synthesis of an imidazole-4,5-dicarboxamide library bearing amino acid esters and alkanamines.

  Molecules (Basel, Switzerland) 20081215

• AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver.

  The Journal of biological chemistry 20081205

• Synthesis of new carbon-11-labeled carboxamide derivatives as potential PET dopamine D3 receptor radioligands.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20081201

• D-ribose therapy in four Polish patients with adenylosuccinate lyase deficiency: absence of positive effect.

  Journal of inherited metabolic disease 20081201

• Inhibition of tumor necrosis factor alpha-stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase.

  Arteriosclerosis, thrombosis, and vascular biology 20081201

• The alpha-subunit of AMPK is essential for submaximal contraction-mediated glucose transport in skeletal muscle in vitro.

  American journal of physiology. Endocrinology and metabolism 20081201

• Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes.

  Diabetes 20081201

• AMPK-independent pathways regulate skeletal muscle fatty acid oxidation.

  The Journal of physiology 20081201

• Adiponectin stimulates phosphorylation of AMP-activated protein kinase alpha in renal glomeruli.

  Journal of molecular histology 20081201

• Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinase.

  The Journal of biological chemistry 20081121

• Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells.

  Biochemical and biophysical research communications 20081121

• Stimulation of glucose transport in response to activation of distinct AMPK signaling pathways.

  American journal of physiology. Cell physiology 20081101

• Differential attenuation of AMPK activation during acute exercise following exercise training or AICAR treatment.

  Journal of applied physiology (Bethesda, Md. : 1985) 20081101

• Is ZMP the toxic metabolite in Lesch-Nyhan disease?

  Medical hypotheses 20081101

• Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling.

  Journal of biochemistry 20081101

• AICAR decreases the activity of two distinct amiloride-sensitive Na+-permeable channels in H441 human lung epithelial cell monolayers.

  American journal of physiology. Lung cellular and molecular physiology 20081101

• Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle.

  American journal of physiology. Endocrinology and metabolism 20081101

• Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice.

  Diabetes 20081101

• Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.

  Molecular endocrinology (Baltimore, Md.) 20081101

• Are 'exercise pills' the answer to the growing problem of physical inactivity?

  British journal of sports medicine 20081101

• AMP-activated protein kinase and hypoxic pulmonary vasoconstriction.

  European journal of pharmacology 20081024

• The exercise pill--too good to be true?

  The New England journal of medicine 20081023

• Validated hydrophilic interaction LC-MS/MS method for simultaneous quantification of dacarbazine and 5-amino-4-imidazole-carboxamide in human plasma.

  Talanta 20081019

• AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells.

  Arteriosclerosis, thrombosis, and vascular biology 20081001

• Globular adiponectin stimulates glucose transport in type 2 diabetic muscle.

  Diabetes/metabolism research and reviews 20081001

• Can patients with type 2 diabetes be treated with 5'-AMP-activated protein kinase activators?

  Diabetologia 20081001

• Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients.

  Diabetologia 20081001

• The need for a multi-level biochemical approach to defeat cancer that will also support the host.

  Medical hypotheses 20081001

• Small molecules can have big effects on endurance.

  Nature chemical biology 20081001

• Potential role of lipin-1 in exercise-induced mitochondrial biogenesis.

  Biochemical and biophysical research communications 20080926

• The anti-diabetic AMPK activator AICAR reduces IL-6 and IL-8 in human adipose tissue and skeletal muscle cells.

  Molecular and cellular endocrinology 20080924

• Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction.

  Circulation 20080923

• AICAR activates AMPK and alters PIP2 association with the epithelial sodium channel ENaC to inhibit Na+ transport in H441 lung epithelial cells.

  The Journal of physiology 20080915

• Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.

  Diabetes 20080901

• Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats.

  Endocrinology 20080901

• Crosstalk between the AMP-activated kinase and insulin signaling pathways rescues murine blastocyst cells from insulin resistance.

  Reproduction (Cambridge, England) 20080901

• AMP-activated protein kinase agonist dose dependently improves function and reduces apoptosis in glucotoxic beta-cells without changing triglyceride levels.

  Journal of molecular endocrinology 20080901

• Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury.

  American journal of physiology. Lung cellular and molecular physiology 20080901

• Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cells.

  American journal of physiology. Cell physiology 20080901

• Gene polymorphisms and pharmacogenetics in rheumatoid arthritis.

  Current genomics 20080901

• AMPK and PPARdelta agonists are exercise mimetics.

  Cell 20080808

• Na(+)-K (+) pump location and translocation during muscle contraction in rat skeletal muscle.

  Pflugers Archiv : European journal of physiology 20080801

• Cellular energetic status supervises the synthesis of bis-diphosphoinositol tetrakisphosphate independently of AMP-activated protein kinase.

  Molecular pharmacology 20080801

• Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance.

  American journal of physiology. Endocrinology and metabolism 20080801

• AMPK activator, AICAR, inhibits palmitate-induced apoptosis in osteoblast.

  Bone 20080801

• Effect of fasting on PPARgamma and AMPK activity in adipocytes.

  Diabetes research and clinical practice 20080801

• Synthesis of 3'-deoxy-3'-C-methyl nucleoside derivatives.

  Bioorganic & medicinal chemistry 20080801

• Acadesine, an adenosine-regulating agent with the potential for widespread indications.

  Expert opinion on pharmacotherapy 20080801

• Can exercise mimetics substitute for exercise?

  Cell metabolism 20080801

• A clean-up method by photocatalysis for HPLC analysis of iprodione in dry basil.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20080801

• Role of AMP-activated protein kinase in the control of appetite.

  Journal of neuroendocrinology 20080701

• AM251 suppresses the viability of HepG2 cells through the AMPK (AMP-activated protein kinase)-JNK (c-Jun N-terminal kinase)-ATF3 (activating transcription factor 3) pathway.

  Biochemical and biophysical research communications 20080613

• Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line.

  Experimental cell research 20080610

• Enterostatin inhibition of angiogenesis: possible role of pAMPK and vascular endothelial growth factor A (VEGF-A).

  International journal of obesity (2005) 20080601

• AMP-activated protein kinase is essential for survival in chronic hypoxia.

  Biochemical and biophysical research communications 20080530

• Role of AMP-activated protein kinase in autophagy and proteasome function.

  Biochemical and biophysical research communications 20080509

• Bis(5-amino-4-amino-carbonyl-1H-imid-azol-3-ium) (5-amino-4-amino-carbonyl-1H-imidazol-3-ium-κO)-di-μ-chlorido-hepta-chlorido-dibismuth(III) mono-hydrate.

  Acta crystallographica. Section E, Structure reports online 20080501

• Genotoxic effects of the pesticides Rubigan, Omite and Rovral in root-meristem cells of Crepis capillaris L.

  Mutation research 20080430

• Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle.

  The Journal of biological chemistry 20080411

• Rapid analysis of multiple pesticide residues in fruit-based baby food using programmed temperature vaporiser injection-low-pressure gas chromatography-high-resolution time-of-flight mass spectrometry.

  Journal of chromatography. A 20080404

• Adiponectin antagonizes stimulatory effect of tumor necrosis factor-alpha on vascular smooth muscle cell calcification: regulation of growth arrest-specific gene 6-mediated survival pathway by adenosine 5'-monophosphate-activated protein kinase.

  Endocrinology 20080401

• 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside reduces glucose uptake via the inhibition of Na+/H+ exchanger 1 in isolated rat ventricular cardiomyocytes.

  Endocrinology 20080401

• Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats.

  American journal of physiology. Renal physiology 20080401

• alpha2 But not alpha1 AMP-activated protein kinase mediates oxidative stress-induced inhibition of retinal pigment epithelium cell phagocytosis of photoreceptor outer segments.

  The Journal of biological chemistry 20080314

• AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase.

  The Journal of biological chemistry 20080307

• Ethanol consumption impairs regulation of fatty acid metabolism by decreasing the activity of AMP-activated protein kinase in rat liver.

  Biochimie 20080301

• Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes.

  Molecular endocrinology (Baltimore, Md.) 20080301

• AMPK activation attenuates S6K1, 4E-BP1, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contractions.

  Journal of applied physiology (Bethesda, Md. : 1985) 20080301

• The effect of AMP-activated kinase activation on gonadotrophin-releasing hormone secretion in GT1-7 cells and its potential role in hypothalamic regulation of the oestrous cyclicity in rats.

  Journal of neuroendocrinology 20080301

• Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

  American journal of physiology. Regulatory, integrative and comparative physiology 20080301

• SIK2 can be activated by deprivation of nutrition and it inhibits expression of lipogenic genes in adipocytes.

  Obesity (Silver Spring, Md.) 20080301

• Implication of S-adenosylhomocysteine hydrolase in inhibition of TNF-alpha- and IL-1beta-induced expression of inflammatory mediators by AICAR in RPE cells.

  Investigative ophthalmology & visual science 20080301

• AMP-activated protein kinase activation by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression.

  Journal of pharmacological sciences 20080301

• Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 5-aminoimidazole-4-carboxamide riboside is independent of AMP-activated protein kinase.

  Journal of cellular biochemistry 20080215

• IGF-1 receptor signaling pathways and effects of AMPK activation on IGF-1-induced progesterone secretion in hen granulosa cells.

  Domestic animal endocrinology 20080201

• Contrasting effects of exercise, AICAR, and increased fatty acid supply on in vivo and skeletal muscle glucose metabolism.

  Journal of applied physiology (Bethesda, Md. : 1985) 20080201

• AMP-activated protein kinase phosphorylates transcription factors of the CREB family.

  Journal of applied physiology (Bethesda, Md. : 1985) 20080201

• Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells.

  Hepatology (Baltimore, Md.) 20080201

• High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase.

  Hepatology (Baltimore, Md.) 20080201

• Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro.

  Journal of neuroscience methods 20080130

• Transcriptional mechanism of suppression of insulin gene expression by AMP-activated protein kinase activator 5-amino-4-imidazolecarboxamide riboside (AICAR) in beta-cells.

  Biochemical and biophysical research communications 20080125

• Effect of alcohols on the stability of iprodione in solution.

  Journal of agricultural and food chemistry 20080123

• AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade.

  Biochemical pharmacology 20080115

• AMPK activation with AICAR provokes an acute fall in plasma [K+].

  American journal of physiology. Cell physiology 20080101

• Chemical hypoxia-induced glucose transporter-4 translocation in neonatal rat cardiomyocytes.

  Archives of medical research 20080101

• Molecular characterization of benzimidazole-resistant isolates of Cladosporium fulvum.

  FEMS microbiology letters 20080101

• Live or let die: E2F1 and PI3K pathways intersect to make life or death decisions.

  Cancer cell 20080101

• An E2F1-dependent gene expression program that determines the balance between proliferation and cell death.

  Cancer cell 20080101

• Clinical, biochemical, neuropathological and molecular findings of the first Polish case of adenylosuccinase deficiency.

  Folia neuropathologica 20080101

• Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation.

  PloS one 20080101

• Acadesine: AICA riboside, ARA 100, arasine, GP 1 110.

  Drugs in R&D 20080101

• AMPK alpha1 activation is required for stimulation of glucose uptake by twitch contraction, but not by H2O2, in mouse skeletal muscle.

  PloS one 20080101

• Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain.

  Molecular cancer 20080101

• Macropinocytosis is decreased in diabetic mouse macrophages and is regulated by AMPK.

  BMC immunology 20080101

• AMP-activated protein kinase-regulated activation of the PGC-1alpha promoter in skeletal muscle cells.

  PloS one 20080101

• Central exercise action increases the AMPK and mTOR response to leptin.

  PloS one 20080101

• Vasopressin regulates the phosphorylation state of AMP-activated protein kinase (AMPK) in MDCK-C7 cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101

• AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner.

  Molecular and cellular biochemistry 20071201

• LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle.

  American journal of physiology. Endocrinology and metabolism 20071201

• Adiponectin suppresses IkappaB kinase activation induced by tumor necrosis factor-alpha or high glucose in endothelial cells: role of cAMP and AMP kinase signaling.

  American journal of physiology. Endocrinology and metabolism 20071201

• AICAR inhibits proliferation and induced S-phase arrest, and promotes apoptosis in CaSki cells.

  Acta pharmacologica Sinica 20071201

• 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICA-riboside) as a targeting agent for therapy of patients with acute lymphoblastic leukemia: are we there and are there pitfalls?

  Journal of pediatric hematology/oncology 20071201

• Targeting skeletal muscle AMP-activated protein kinase to treat type 2 diabetes.

  Current diabetes reports 20071201

• Maternal diabetes adversely affects AMP-activated protein kinase activity and cellular metabolism in murine oocytes.

  American journal of physiology. Endocrinology and metabolism 20071101

• Ceramide and adenosine 5'-monophosphate-activated protein kinase are two novel regulators of 11beta-hydroxysteroid dehydrogenase type 1 expression and activity in cultured preadipocytes.

  Endocrinology 20071101

• Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise.

  American journal of physiology. Endocrinology and metabolism 20071101

• A central role for neuronal adenosine 5'-monophosphate-activated protein kinase in cancer-induced anorexia.

  Endocrinology 20071101

• Five-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates poly (I:C)-induced airway inflammation in a murine model of asthma.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20071101

• Iprodione delays male rat pubertal development, reduces serum testosterone levels, and decreases ex vivo testicular testosterone production.

  Toxicology letters 20071101

• Dissociation of AMP-activated protein kinase and p38 mitogen-activated protein kinase signaling in skeletal muscle.

  Biochemical and biophysical research communications 20071019

• Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.

  The Biochemical journal 20071015

• Differential involvement of histidine kinase receptors in pseudohyphal development, stress adaptation, and drug sensitivity of the opportunistic yeast Candida lusitaniae.

  Eukaryotic cell 20071001

• Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle.

  American journal of physiology. Endocrinology and metabolism 20071001

• Activation of adenosine monophosphate activated protein kinase inhibits growth of multiple myeloma cells.

  Experimental cell research 20071001

• Proteomics analysis of hypothalamic response to energy restriction in dairy cows.

  Proteomics 20071001

• The AMP-activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-b-D-ribonucleoside, regulates lactate production in rat Sertoli cells.

  Journal of molecular endocrinology 20071001

• Structural insight into AMPK regulation: ADP comes into play.

  Structure (London, England : 1993) 20071001

• A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation.

  Brain research 20070907

• AMP kinase activation increases glucose uptake, decreases apoptosis, and improves pregnancy outcome in embryos exposed to high IGF-I concentrations.

  Diabetes 20070901

• Upregulation of IL-6 mRNA by IL-6 in skeletal muscle cells: role of IL-6 mRNA stabilization and Ca2+-dependent mechanisms.

  American journal of physiology. Cell physiology 20070901

• Airway smooth muscle proliferation and mechanics: effects of AMP kinase agonists.

  Molecular & cellular biomechanics : MCB 20070901

• Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKalpha.

  Experimental & molecular medicine 20070831

• Fatty acid synthase gene regulation in primary hypothalamic neurons.

  Neuroscience letters 20070823

• Determination of 5-aminoimidazole-4-carboxamide in human plasma by ion-pair extraction and LC-MS/MS.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070815

• Effects of adenosine monophosphate-activated kinase activators on bovine oocyte nuclear maturation in vitro.

  Molecular reproduction and development 20070801

• Polymorphisms in folate, pyrimidine, and purine metabolism are associated with efficacy and toxicity of methotrexate in psoriasis.

  The Journal of investigative dermatology 20070801

• 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.

  Diabetes 20070801

• Negligible direct lactate oxidation in subsarcolemmal and intermyofibrillar mitochondria obtained from red and white rat skeletal muscle.

  The Journal of physiology 20070801

• Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells.

  British journal of pharmacology 20070801

• 5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside stimulates tyrosine hydroxylase activity and catecholamine secretion by activation of AMP-activated protein kinase in PC12 cells.

  Journal of neuroendocrinology 20070801

• Covariate heterogeneity in meta-analysis: criteria for deciding between meta-regression and individual patient data.

  Statistics in medicine 20070710

• AMPK activation stimulates myofibrillar protein degradation and expression of atrophy-related ubiquitin ligases by increasing FOXO transcription factors in C2C12 myotubes.

  Bioscience, biotechnology, and biochemistry 20070701

• [Quantum chemistry study on fluorescence spectra of three aromatic hydrocarbons].

  Guang pu xue yu guang pu fen xi = Guang pu 20070701

• AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside.

  The Biochemical journal 20070615

• Activation of AMP kinase alpha1 subunit induces aortic vasorelaxation in mice.

  The Journal of physiology 20070615

• Neurotensin receptor binding and neurotensin-induced growth signaling in prostate cancer PC3 cells are sensitive to metabolic stress.

  Regulatory peptides 20070607

• AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells.

  American journal of physiology. Endocrinology and metabolism 20070601

• A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism.

  American journal of physiology. Endocrinology and metabolism 20070601

• Activation of AMP-activated protein kinase stimulates proopiomelanocortin gene transcription in AtT20 corticotroph cells.

  American journal of physiology. Endocrinology and metabolism 20070601

• Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070601

• S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase.

  Cell metabolism 20070601

• Preparation and characterization of inclusion complex of iprodione and beta-cyclodextrin to improve fungicidal activity.

  Journal of agricultural and food chemistry 20070502

• Role of glycogen content in insulin resistance in human muscle cells.

  Journal of cellular physiology 20070501

• Interference with energy metabolism by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside induces HPV suppression in cervical carcinoma cells and apoptosis in the absence of LKB1.

  The Biochemical journal 20070501

• Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction.

  American journal of physiology. Endocrinology and metabolism 20070501

• A novel function for the N-terminal nucleophile hydrolase fold demonstrated by the structure of an archaeal inosine monophosphate cyclohydrolase.

  Biochemistry 20070501

• Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.

  Acta crystallographica. Section D, Biological crystallography 20070501

• 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling.

  Molecular cancer therapeutics 20070501

• Resveratrol stimulates AMP kinase activity in neurons.

  Proceedings of the National Academy of Sciences of the United States of America 20070424

• An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-beta-D-ribofuranoside.

  Bioorganic & medicinal chemistry letters 20070415

• AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis.

  Cellular signalling 20070401

• Adenosine 5'-monophosphate kinase-activated protein kinase (PRKA) activators delay meiotic resumption in porcine oocytes.

  Biology of reproduction 20070401

• Glucose, insulin, and leptin signaling pathways modulate nitric oxide synthesis in glucose-inhibited neurons in the ventromedial hypothalamus.

  American journal of physiology. Regulatory, integrative and comparative physiology 20070401

• Leucine stimulates mammalian target of rapamycin signaling in C2C12 myoblasts in part through inhibition of adenosine monophosphate-activated protein kinase.

  Journal of animal science 20070401

• Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overload-induced cardiac hypertrophy.

  Journal of cellular biochemistry 20070401

• Determination of iprodione in agrochemicals by infrared and Raman spectrometry.

  Analytical and bioanalytical chemistry 20070401

• AMP-activated protein kinase mediates carotid body excitation by hypoxia.

  The Journal of biological chemistry 20070316

• Meiotic induction by heat stress in mouse oocytes: involvement of AMP-activated protein kinase and MAPK family members.

  Biology of reproduction 20070301

• Effect of acute activation of 5'-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle.

  Journal of applied physiology (Bethesda, Md. : 1985) 20070301

• Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5' monophosphate-activated protein kinase (AMPK).

  Biology of reproduction 20070301

• Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia.

  Endocrinology 20070301

• Roles of putative His-to-Asp signaling modules HPT-1 and RRG-2, on viability and sensitivity to osmotic and oxidative stresses in Neurospora crassa.

  Current genetics 20070301

• Addition of adenosine monophosphate-activated protein kinase activators to University of Wisconsin solution: a way of protecting rat steatotic livers.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20070301

• Characterization of the NikA histidine kinase implicated in the phosphorelay signal transduction of Aspergillus nidulans, with special reference to fungicide responses.

  Bioscience, biotechnology, and biochemistry 20070301

• The role of AMP kinase in diabetes.

  The Indian journal of medical research 20070301

• Inhibition of hepatic phosphatidylcholine synthesis by 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside is independent of AMP-activated protein kinase activation.

  The Journal of biological chemistry 20070216

• AMP-activated protein kinase in metabolic control and insulin signaling.

  Circulation research 20070216

• Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis.

  Cell metabolism 20070207

• Immunoassay for iprodione: key estimation for residue analysis and method validation with chromatographic technique.

  Analytica chimica acta 20070205

• Fluid shear stress and NO decrease the activity of the hydroxy-methylglutaryl coenzyme A reductase in endothelial cells via the AMP-activated protein kinase and FoxO1.

  Circulation research 20070202

• A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy.

  American journal of physiology. Renal physiology 20070201

• Glucose-transport regulation in leukemic cells: how can H2O2 mimic stem cell factor effects?

  Antioxidants & redox signaling 20070201

• Two-component response regulators Ssk1p and Skn7p additively regulate high-osmolarity adaptation and fungicide sensitivity in Cochliobolus heterostrophus.

  Eukaryotic cell 20070201

• Potentiation of insulin-stimulated glucose transport by the AMP-activated protein kinase.

  American journal of physiology. Cell physiology 20070101

• 5'-AMP-activated protein kinase activation prevents postischemic leukocyte-endothelial cell adhesive interactions.

  American journal of physiology. Heart and circulatory physiology 20070101

• Critical role of 5'-AMP-activated protein kinase in the stimulation of glucose transport in response to inhibition of oxidative phosphorylation.

  American journal of physiology. Cell physiology 20070101

• Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle.

  American journal of physiology. Endocrinology and metabolism 20070101

• Influence of humic substances on the photolysis of aqueous pesticide residues.

  Chemosphere 20070101

• Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity.

  Diabetologia 20070101

• Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation.

  Free radical biology & medicine 20070101

• Analysis of 3,5-dichloroaniline as a biomarker of vinclozolin and iprodione in human urine using liquid chromatography/triple quadrupole mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20070101

• Involvement of AMPK signaling cascade in capsaicin-induced apoptosis of HT-29 colon cancer cells.

  Annals of the New York Academy of Sciences 20070101

• Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis risk.

  Clinical chemistry and laboratory medicine 20070101

• Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy.

  Molecular cancer 20070101

• Identification of new reference genes for the normalisation of canine osteoarthritic joint tissue transcripts from microarray data.

  BMC molecular biology 20070101

• Formamide as the main building block in the origin of nucleic acids.

  BMC evolutionary biology 20070101

• [Pemetrexed: from preclinic to clinic].

  Bulletin du cancer 20070101

• Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling.

  BMC biochemistry 20070101

• Solid phase synthesis of nucleobase and ribose modified inosine nucleoside analogues.

  Nucleosides, nucleotides & nucleic acids 20070101

• [Occurrence of pesticide residues in raspberries in 2000-2005].

  Roczniki Panstwowego Zakladu Higieny 20070101

• Small-molecule targeting of heat shock protein 90 chaperone function: rational identification of a new anticancer lead.

  Journal of medicinal chemistry 20061228

• [Effects of globular adiponectin, glucose and free fatty acid on AMPK and ACC phosphorylation in INS-1 beta cells].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20061218

• Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver.

  Molecular pharmacology 20061201

• AMP-activated protein kinase and the regulation of autophagic proteolysis.

  The Journal of biological chemistry 20061117

• Inhibition of fructose-1,6-bisphosphatase by aminoimidazole carboxamide ribotide prevents growth of Salmonella enterica purH mutants on glycerol.

  The Journal of biological chemistry 20061110

• Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion.

  American journal of physiology. Endocrinology and metabolism 20061101

• Inhibition of insulin-stimulated glycogen synthesis by 5-aminoimidasole-4-carboxamide-1-beta-d-ribofuranoside-induced adenosine 5'-monophosphate-activated protein kinase activation: interactions with Akt, glycogen synthase kinase 3-3alpha/beta, and glycogen synthase in isolated rat soleus muscle.

  Endocrinology 20061101

• AICAR inhibits the Na+/H+ exchanger in rat hearts--possible contribution to cardioprotection.

  Pflugers Archiv : European journal of physiology 20061101

• Feasibility of LC/TOFMS and elemental database searching as a spectral library for pesticides in food.

  Food additives and contaminants 20061101

• The effects of 5-aminoimidazole-4-carboxamide riboside on the pancreas in neonatal streptozotocin-diabetic rats.

  Acta diabetologica 20061101

• Application of comprehensive two-dimensional gas chromatography with nitrogen-selective detection for the analysis of fungicide residues in vegetable samples.

  Journal of chromatography. A 20061027

• Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase.

  The Journal of biological chemistry 20061027

• Diagnosing AICA-ribosiduria by capillary electrophoresis.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061020

• Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells.

  Cancer research 20061015

• TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase.

  Cellular signalling 20061001

• Molecular characterization of the two-component histidine kinase gene from Monilinia fructicola.

  Pest management science 20061001

• Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase.

  Diabetes 20061001

• Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats.

  Diabetes 20061001

• Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis.

  Arthritis and rheumatism 20061001

• Increased ATP-sensitive K+ channel expression during acute glucose deprivation.

  Biochemical and biophysical research communications 20060929

• 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-induced AMP-activated protein kinase phosphorylation inhibits basal and insulin-stimulated glucose uptake, lipid synthesis, and fatty acid oxidation in isolated rat adipocytes.

  The Journal of biological chemistry 20060908

• Muscle-specific overexpression of wild type and R225Q mutant AMP-activated protein kinase gamma3-subunit differentially regulates glycogen accumulation.

  American journal of physiology. Endocrinology and metabolism 20060901

• Induction of meiotic maturation in mouse oocytes by adenosine analogs.

  Molecular reproduction and development 20060901

• The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans.

  The Journal of clinical endocrinology and metabolism 20060901

• Immunomodulatory effect of combination therapy with lovastatin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside alleviates neurodegeneration in experimental autoimmune encephalomyelitis.

  The American journal of pathology 20060901

• The PPAR gamma agonist troglitazone induces musclin mRNA expression in human myotubes.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20060901

• Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside.

  Molecular cancer therapeutics 20060901

• 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction.

  Journal of neuroscience research 20060815

• Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors.

  Bioorganic & medicinal chemistry letters 20060815

• Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-Mammalian target of rapamycin pathway.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060802

• Prolonged AMPK activation increases the expression of fatty acid transporters in cardiac myocytes and perfused hearts.

  Molecular and cellular biochemistry 20060801

• Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta.

  Molecular and cellular biology 20060801

• Biochemical and structural studies of N5-carboxyaminoimidazole ribonucleotide mutase from the acidophilic bacterium Acetobacter aceti.

  Biochemistry 20060711

• Post-reperfusion myocardial infarction: long-term survival improvement using adenosine regulation with acadesine.

  Journal of the American College of Cardiology 20060704

• Moving preconditioning from bench to bedside.

  Journal of the American College of Cardiology 20060704

• Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR.

  American journal of physiology. Endocrinology and metabolism 20060701

• AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits.

  Diabetes 20060701

• Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle.

  Diabetes 20060701

• S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase.

  Gastroenterology 20060701

• AMP-activated protein kinase activation modulates progesterone secretion in granulosa cells from hen preovulatory follicles.

  The Journal of endocrinology 20060701

• Biodegradation of the fungicide iprodione by Zygosaccharomyces rouxii strain DBVPG 6399.

  Journal of agricultural and food chemistry 20060628

• Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine.

  Journal of lipid research 20060601

• Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells.

  Hypertension (Dallas, Tex. : 1979) 20060601

• Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation.

  Diabetes 20060601

• Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway.

  Diabetes 20060601

• AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3.

  Biochemical pharmacology 20060528

• Cytokine secretion by human adipocytes is differentially regulated by adiponectin, AICAR, and troglitazone.

  Biochemical and biophysical research communications 20060512

• Human resistin promotes macrophage lipid accumulation.

  Diabetologia 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• AMPK activation inhibits the expression of HIF-1alpha induced by insulin and IGF-1.

  Biochemical and biophysical research communications 20060421

• Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases.

  The Biochemical journal 20060401

• 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation.

  Diabetes 20060401

• 5-amino-4-imidazolecarboxamide riboside potentiates both transport of reduced folates and antifolates by the human reduced folate carrier and their subsequent metabolism.

  Cancer research 20060401

• AMPK regulation of mouse oocyte meiotic resumption in vitro.

  Developmental biology 20060315

• Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue.

  American journal of physiology. Endocrinology and metabolism 20060301

• Relationship between 5-aminoimidazole-4-carboxamide-ribotide and AMP-activated protein kinase activity in the perfused mouse heart.

  American journal of physiology. Heart and circulatory physiology 20060301

• Oleic acid uptake by in vitro English sparrow skeletal muscle.

  Journal of experimental zoology. Part A, Comparative experimental biology 20060301

• α2 isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle.

  Metabolism: clinical and experimental 20060301

• AMP-activated protein kinase activation by adrenoceptors in L6 skeletal muscle cells: mediation by alpha1-adrenoceptors causing glucose uptake.

  Diabetes 20060301

• AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1.

  Biochemical and biophysical research communications 20060203

• AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2alpha in adipocytes.

  Biochemical and biophysical research communications 20060203

• Role of 5'-AMP-activated protein kinase in stimulation of glucose transport in response to inhibition of oxidative phosphorylation.

  American journal of physiology. Cell physiology 20060201

• Regulation of AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation by palmitate in skeletal muscle cells.

  Journal of lipid research 20060201

• Activation of AMP-activated protein kinase enhances angiotensin ii-induced proliferation in cardiac fibroblasts.

  Hypertension (Dallas, Tex. : 1979) 20060201

• Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells.

  Immunology and cell biology 20060201

• Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase.

  Diabetes 20060201

• Development of an SPME-GC-MS/MS method for the determination of pesticides in rainwater: laboratory and field experiments.

  Environmental pollution (Barking, Essex : 1987) 20060101

• Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells.

  Diabetes 20060101

• A pull-down assay for 5' AMP-activated protein kinase activity using the GST-fused protein.

  Molecular biotechnology 20060101

• AMP-activated protein kinase and type 2 diabetes.

  Current medicinal chemistry 20060101

• Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis.

  Arthritis research & therapy 20060101

• Does AMP-activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation?

  Advances in experimental medicine and biology 20060101

• AMPK or ZMPK?

  Medical hypotheses 20060101

• Bioefficacy of iprodione against two desapers, its compatibility with T. harzianum and residues on cabbage crop.

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20060101

• Analysis of intracellular nucleotides by capillary electrophoresis-mass spectrometry.

  Nucleosides, nucleotides & nucleic acids 20060101

• Synthesis and mass spectrometric fragmentation characteristics of imidazole ribosides-analogs of intermediates of purine de novo synthetic pathway.

  Nucleosides, nucleotides & nucleic acids 20060101

• 5 '-Amino-4-imidazolecarboxamide riboside induces apoptosis in human neuroblastoma cells via the mitochondrial pathway.

  Nucleosides, nucleotides & nucleic acids 20060101

• Determination and validation of a simple high-performance liquid chromatographic method for simultaneous assay of iprodione and vinclozolin in human urine.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051215

• Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists.

  Bioorganic & medicinal chemistry letters 20051215

• A role for hypothalamic malonyl-CoA in the control of food intake.

  The Journal of biological chemistry 20051202

• AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: a possible role for AMPK.

  Biochemical and biophysical research communications 20051202

• Muscle contractions, AICAR, and insulin cause phosphorylation of an AMPK-related kinase.

  American journal of physiology. Endocrinology and metabolism 20051201

• 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside renders glucose output by the liver of the dog insensitive to a pharmacological increment in insulin.

  American journal of physiology. Endocrinology and metabolism 20051201

• Sorption, degradation and leaching of the fungicide iprodione in a golf green under Scandinavian conditions: measurements, modelling and risk assessment.

  Pest management science 20051201

• Adenosine monophosphate-activated protein kinase and nitric oxide in rat steatotic liver transplantation.

  Journal of hepatology 20051201

• Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase.

  American journal of physiology. Endocrinology and metabolism 20051201

• Fine-tuning insulin and nitric oxide signalling by turning up the AMPs: new insights into AMP-activated protein kinase signalling.

  Diabetologia 20051201

• Insulin signalling downstream of protein kinase B is potentiated by 5'AMP-activated protein kinase in rat hearts in vivo.

  Diabetologia 20051201

• AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats.

  Alcoholism, clinical and experimental research 20051201

• 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase.

  The Journal of biological chemistry 20051125

• AMP-activated protein kinase alpha2 activity is not essential for contraction- and hyperosmolarity-induced glucose transport in skeletal muscle.

  The Journal of biological chemistry 20051125

• AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart.

  Circulation research 20051028

• Adenosine monophosphate-activated protein kinase suppresses vascular smooth muscle cell proliferation through the inhibition of cell cycle progression.

  Circulation research 20051014

• Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes.

  American journal of physiology. Endocrinology and metabolism 20051001

• DNA-bound Bas1 recruits Pho2 to activate ADE genes in Saccharomyces cerevisiae.

  Eukaryotic cell 20051001

• AICAR and hyperosmotic stress increase insulin-stimulated glucose transport.

  Journal of applied physiology (Bethesda, Md. : 1985) 20050901

• Effects of calcineurin activation on insulin-, AICAR- and contraction-induced glucose transport in skeletal muscle.

  The Journal of physiology 20050901

• Metformin reduces adiponectin protein expression and release in 3T3-L1 adipocytes involving activation of AMP activated protein kinase.

  European journal of pharmacology 20050822

• The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.

  The Journal of biological chemistry 20050812

• Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells.

  The Journal of physiology 20050801

• Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells.

  Life sciences 20050729

• Techniques and parameters used in compatibility tests between Beauveria bassiana (Bals) Vuill and in vitro phytosanitary products.

  Pest management science 20050701

• Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes.

  The Journal of biological chemistry 20050701

• Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050701

• AICAR suppresses IL-2 expression through inhibition of GSK-3 phosphorylation and NF-AT activation in Jurkat T cells.

  Biochemical and biophysical research communications 20050701

• 5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis.

  Journal of immunology (Baltimore, Md. : 1950) 20050701

• The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation.

  Oncogene 20050616

• Contraction- and hypoxia-stimulated glucose transport is mediated by a Ca2+-dependent mechanism in slow-twitch rat soleus muscle.

  American journal of physiology. Endocrinology and metabolism 20050601

• AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus muscle.

  The Journal of physiology 20050601

• AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle.

  The Journal of physiology 20050601

• Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1.

  Diabetologia 20050601

• Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke.

  The Journal of biological chemistry 20050527

• 5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways.

  Biochemical and biophysical research communications 20050520

• Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction.

  The EMBO journal 20050518

• Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside.

  American journal of physiology. Endocrinology and metabolism 20050501

• Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule.

  Genetics 20050501

• Molecular mechanism of the aryl hydrocarbon receptor activation by the fungicide iprodione in rainbow trout (Oncorhynchus mykiss) hepatocytes.

  Aquatic toxicology (Amsterdam, Netherlands) 20050430

• AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle.

  Circulation research 20050429

• The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR.

  FEBS letters 20050425

• Long-term AICAR administration and exercise prevents diabetes in ZDF rats.

  Diabetes 20050401

• N-Arylpiperazine-1-carboxamide derivatives: a novel series of orally active nonsteroidal androgen receptor antagonists.

  Chemical & pharmaceutical bulletin 20050401

• Synthesis of a methylene analog of 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide monophosphate (ZMP).

  Bioscience, biotechnology, and biochemistry 20050401

• A Methanocaldococcus jannaschii archaeal signature gene encodes for a 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase. A new enzyme in purine biosynthesis.

  The Journal of biological chemistry 20050325

• Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype.

  Cancer research 20050315

• AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin receptor expression in HepG2 cells.

  Biochemical and biophysical research communications 20050311

• Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins.

  The Biochemical journal 20050301

• AMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low-intensity muscle contraction.

  American journal of physiology. Endocrinology and metabolism 20050301

• Increased potency and efficacy of combined phosphorylase inactivation and glucokinase activation in control of hepatocyte glycogen metabolism.

  Diabetes 20050301

• Dual mechanisms regulating AMPK kinase action in the ischemic heart.

  Circulation research 20050218

• AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.

  The Journal of biological chemistry 20050211

• Depression of cell metabolism and proliferation by membrane-permeable and -impermeable modulators: role for AMP-to-ATP ratio.

  American journal of physiology. Regulatory, integrative and comparative physiology 20050201

• Acadesine induces apoptosis in B cells from mantle cell lymphoma and splenic marginal zone lymphoma.

  Leukemia 20050201

• MEK inhibitors block AICAR-induced maturation in mouse oocytes by a MAPK-independent mechanism.

  Molecular reproduction and development 20050201

• Glucose transport by English sparrow (Passer domesticus) skeletal muscle: have we been chirping up the wrong tree?

  Journal of experimental zoology. Part A, Comparative experimental biology 20050201

• 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside causes acute hepatic insulin resistance in vivo.

  Diabetes 20050201

• Portal venous 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion overcomes hyperinsulinemic suppression of endogenous glucose output.

  Diabetes 20050201

• Base cation stimulation of mycorrhization and photosynthesis of sugar maple on acid soils are coupled by foliar nutrient dynamics.

  The New phytologist 20050201

• Demonstration of an alternative mechanism for G-to-G cross-link formation.

  Journal of the American Chemical Society 20050126

• Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase.

  Biochemistry 20050118

• 5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK.

  The Biochemical journal 20050115

• Role of neuronal energy status in the regulation of adenosine 5'-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior.

  Endocrinology 20050101

• Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity.

  Diabetes 20050101

• Preparation of 5-amino-4-imidazole-N-succinocarboxamide ribotide, 5-amino-4-imidazole-N-succinocarboxamide riboside and succinyladenosine, compounds usable in diagnosis and research of adenylosuccinate lyase deficiency.

  Journal of inherited metabolic disease 20050101

• One-bead-one-compound library of end-capped dipeptides and deconvolution by microflow NMR.

  Journal of combinatorial chemistry 20050101

• Ring opening reactions: synthesis of AICAR analogs as potential antimetabolite agents.

  Nucleosides, nucleotides & nucleic acids 20050101

• Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors.

  Journal of medicinal chemistry 20041230

• Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor alpha by AMP-activated protein kinase.

  The Biochemical journal 20041201

• Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation.

  Toxicological sciences : an official journal of the Society of Toxicology 20041201

• The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.

  Diabetes 20041201

• Mapping of the bovine genes of the de novo AMP synthesis pathway.

  Animal genetics 20041201

• The role of AMP-activated protein kinase in the action of ethanol in the liver.

  Gastroenterology 20041201

• AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR.

  The Journal of biological chemistry 20041112

• AMPK stimulation increases LCFA but not glucose clearance in cardiac muscle in vivo.

  American journal of physiology. Endocrinology and metabolism 20041101

• Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle.

  American journal of physiology. Endocrinology and metabolism 20041101

• Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition.

  Diabetologia 20041101

• AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle.

  American journal of physiology. Endocrinology and metabolism 20041001

• Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels.

  Circulation research 20041001

• The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis.

  Arthritis and rheumatism 20041001

• Adenylosuccinate lyase deficiency--first British case.

  Nucleosides, nucleotides & nucleic acids 20041001

• Cytotoxicity of the dicarboximide fungicides, vinclozolin and iprodione, in rat hepatoma-derived Fa32 cells.

  Alternatives to laboratory animals : ATLA 20041001

• Attenuation of ischemia-reperfusion injury in a canine model of autologous renal transplantation.

  Transplantation 20040915

• Prior serum- and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake.

  American journal of physiology. Endocrinology and metabolism 20040901

• Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, controls muscle glycogen synthesis.

  Endocrinology 20040901

• Effect of fungicide iprodione on soil bacterial community.

  Ecotoxicology and environmental safety 20040901

• AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese females.

  The Journal of clinical endocrinology and metabolism 20040901

• Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis.

  Arthritis and rheumatism 20040901

• Stimulators of AMP-activated protein kinase inhibit the respiratory burst in human neutrophils.

  FEBS letters 20040827

• AMP-activated protein kinase: the guardian of cardiac energy status.

  The Journal of clinical investigation 20040816

• AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms.

  Biochemical and biophysical research communications 20040813

• Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c.

  Endocrinology 20040801

• Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.

  American journal of physiology. Endocrinology and metabolism 20040801

• Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus.

  Diabetes 20040801

• Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte.

  The Journal of biological chemistry 20040730

• AMP-activated protein kinase inhibits angiotensin II-stimulated vascular smooth muscle cell proliferation.

  Circulation 20040727

• AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivo.

  Diabetes 20040701

• Sending the signal: molecular mechanisms regulating glucose uptake.

  Medicine and science in sports and exercise 20040701

• 5'-aminoimidazole-4-carboxyamide-ribonucleoside-activated glucose transport is not prevented by nitric oxide synthase inhibition in rat isolated skeletal muscle.

  Clinical and experimental pharmacology & physiology 20040701

• Insulin-nonspecific reduction in skeletal muscle glucose transport in high-fat-fed rats.

  Metabolism: clinical and experimental 20040701

• MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways.

  American journal of physiology. Cell physiology 20040601

• AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC.

  American journal of human genetics 20040601

• AMP kinase-induced skeletal muscle glucose but not long-chain fatty acid uptake is dependent on nitric oxide.

  Diabetes 20040601

• Preliminary study on pharmacokinetics of dacarbazine and fotemustine in glioblastoma multiforme patients does not indicate gender-specific differences.

  Anti-cancer drugs 20040601

• 5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages.

  Biochemical and biophysical research communications 20040528

• Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase.

  Biochemical pharmacology 20040515

• C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase.

  The Journal of biological chemistry 20040507

• A glucose response element from the S. cerevisiae hexose transporter HXT1 gene is sensitive to glucose in human fibroblasts.

  Journal of molecular biology 20040507

• Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status.

  The Journal of biological chemistry 20040416

• AICAR stimulates adiponectin and inhibits cytokines in adipose tissue.

  Biochemical and biophysical research communications 20040409

• Activation of glycogen phosphorylase with 5-aminoimidazole-4-carboxamide riboside (AICAR). Assessment of glycogen as a precursor of mannosyl residues in glycoconjugates.

  The Journal of biological chemistry 20040326

• AMP-activated protein kinase plays a role in the control of food intake.

  The Journal of biological chemistry 20040326

• Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).

  The Biochemical journal 20040315

• AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus.

  Journal of neurochemistry 20040301

• Cytotoxicity and transcriptional activation of stress genes in human liver carcinoma (HepG2) cells exposed to iprodione.

  International journal of environmental research and public health 20040301

• Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor.

  Biochemistry 20040210

• Effects of acute bouts of running and swimming exercise on PGC-1alpha protein expression in rat epitrochlearis and soleus muscle.

  American journal of physiology. Endocrinology and metabolism 20040201

• Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions.

  Diabetes 20040201

• [The antiandrogenic effect of dimethachlon and its mechanism].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20040201

• 5-Aminoimidazole-4-carboxamide-ribonucleoside enhances oxidative stress-induced apoptosis through activation of nuclear factor-kappaB in mouse Neuro 2a neuroblastoma cells.

  Neuroscience letters 20040116

• Multiple independent kinase cascades are targeted by hyperosmotic stress but only one activates stress kinase p38.

  Experimental cell research 20040115

• 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040114

• Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

  The Journal of biological chemistry 20040109

• Glucose 6-phosphate causes translocation of phosphorylase in hepatocytes and inactivates the enzyme synergistically with glucose.

  The Biochemical journal 20040101

• Dicarboximide resistance in field isolates of Alternaria alternata is mediated by a mutation in a two-component histidine kinase gene.

  Fungal genetics and biology : FG & B 20040101

• Adsorption, transformation, and bioavailability of the fungicides carbendazim and iprodione in soil, alone and in combination.

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20040101

• AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets.

  Thrombosis and haemostasis 20031101

• Effects of chronic AICAR administration on the metabolic and contractile phenotypes of rat slow- and fast-twitch skeletal muscles.

  Canadian journal of physiology and pharmacology 20031101

• Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes.

  The Journal of biological chemistry 20031003

• Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients.

  Diabetologia 20031001

• Small molecule inhibition of hepatitis C virus E2 binding to CD81.

  Virology 20030915

• Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles.

  Journal of applied physiology (Bethesda, Md. : 1985) 20030901

• Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death.

  Endocrinology 20030901

• The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030901

• Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells.

  The Journal of biological chemistry 20030822

• AMPK activation increases uncoupling protein-3 expression and mitochondrial enzyme activities in rat muscle without fibre type transitions.

  The Journal of physiology 20030815

• AMP-activated protein kinase and muscle glucose uptake.

  Acta physiologica Scandinavica 20030801

• AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise.

  Acta physiologica Scandinavica 20030801

• Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function.

  The Journal of biological chemistry 20030718

• Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes.

  The Biochemical journal 20030715

• Intrafamilial variability in the phenotypic expression of adenylosuccinate lyase deficiency: a report on three patients.

  American journal of medical genetics. Part A 20030715

• Contraction-induced fatty acid translocase/CD36 translocation in rat cardiac myocytes is mediated through AMP-activated protein kinase signaling.

  Diabetes 20030701

• PPARgamma coactivator-1alpha expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations.

  American journal of physiology. Cell physiology 20030601

• Glucose regulates EF-2 phosphorylation and protein translation by a protein phosphatase-2A-dependent mechanism in INS-1-derived 832/13 cells.

  The Journal of biological chemistry 20030516

• Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes.

  Blood 20030501

• 5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes.

  Diabetes 20030501

• [Physiological roles of AMP-activated protein kinase (AMPK)].

  Medecine sciences : M/S 20030501

• Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles.

  Journal of applied physiology (Bethesda, Md. : 1985) 20030401

• 5-Aminoimidazole-4-carboxamide 1-beta -D-ribofuranoside (AICAR) stimulates myocardial glycogenolysis by allosteric mechanisms.

  American journal of physiology. Regulatory, integrative and comparative physiology 20030401

• AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase.

  Journal of molecular endocrinology 20030401

• 5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved.

  The Biochemical journal 20030315

• Persistence and effectiveness of iprodione against Alternaria blight in mustard.

  Bulletin of environmental contamination and toxicology 20030301

• Multiresidue pesticide analysis in wines by solid-phase extraction and capillary gas chromatography-mass spectrometric detection with selective ion monitoring.

  Journal of agricultural and food chemistry 20030226

• Characterization of a mutant Bacillus subtilis adenylosuccinate lyase equivalent to a mutant enzyme found in human adenylosuccinate lyase deficiency: asparagine 276 plays an important structural role.

  Biochemistry 20030225

• A possible role for AMP-activated protein kinase in exercise-induced glucose utilization: insights from humans and transgenic animals.

  Biochemical Society transactions 20030201

• Selective suppression of AMP-activated protein kinase in skeletal muscle: update on 'lazy mice'.

  Biochemical Society transactions 20030201

• AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase.

  Diabetologia 20030201

• Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells.

  The Journal of biological chemistry 20030110

• Regulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinase.

  Diabetes 20030101

• A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway.

  Genes to cells : devoted to molecular & cellular mechanisms 20030101

• Putative homologs of SSK22 MAPKK kinase and PBS2 MAPK kinase of Saccharomyces cerevisiae encoded by os-4 and os-5 genes for osmotic sensitivity and fungicide resistance in Neurospora crassa.

  Bioscience, biotechnology, and biochemistry 20030101

• 5'-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells.

  Neuroscience 20030101

• A new approach for syntheses of 2',3'-dideoxy-2',3'-dehydronucleosides using 2,2-difluoro-1,3-dimethylimidazolidine (DFI) as a dehydrating reagent.

  Nucleosides, nucleotides & nucleic acids 20030101

• At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation.

  Journal of biology 20030101

• AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle.

  American journal of physiology. Endocrinology and metabolism 20021201

• ATP depletion increases phosphorylation of elongation factor eEF2 in adult cardiomyocytes independently of inhibition of mTOR signalling.

  FEBS letters 20021120

• Protein kinase inhibitors block the stimulation of the AMP-activated protein kinase by 5-amino-4-imidazolecarboxamide riboside.

  FEBS letters 20021106

• AMP kinase activation ameliorates insulin resistance induced by free fatty acids in rat skeletal muscle.

  American journal of physiology. Endocrinology and metabolism 20021101

• Intermittent increases in cytosolic Ca2+ stimulate mitochondrial biogenesis in muscle cells.

  American journal of physiology. Endocrinology and metabolism 20021101

• AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat.

  American journal of physiology. Endocrinology and metabolism 20021101

• Hemodynamic actions of acute ethanol after resuscitation from traumatic brain injury.

  The Journal of trauma 20021101

• AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats.

  Diabetes 20021001

• Effects of iprodione and fludioxonil on glycerol synthesis and hyphal development in Candida albicans.

  Bioscience, biotechnology, and biochemistry 20021001

• The cryptic adenine deaminase gene of Escherichia coli. Silencing by the nucleoid-associated DNA-binding protein, H-NS, and activation by insertion elements.

  The Journal of biological chemistry 20020830

• Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells.

  FEBS letters 20020828

• Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis.

  Current biology : CB 20020820

• Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle.

  Biochemical and biophysical research communications 20020816

• Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase.

  Endocrinology 20020801

• Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes.

  European journal of biochemistry 20020801

• Application of (13)C-filtered (1)H NMR to evaluate drug action on gluconeogenesis and glycogenolysis simultaneously in isolated rat hepatocytes.

  NMR in biomedicine 20020801

• AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.

  The Journal of biological chemistry 20020705

• Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome.

  Diabetes 20020701

• Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes.

  Current drug targets. Immune, endocrine and metabolic disorders 20020701

• Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport.

  The Journal of biological chemistry 20020628

• Acute and chronic treatment of ob/ob and db/db mice with AICAR decreases blood glucose concentrations.

  Biochemical and biophysical research communications 20020621

• Cloning and characterization of methenyltetrahydrofolate synthetase from Saccharomyces cerevisiae.

  The Journal of biological chemistry 20020607

• Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes.

  American journal of physiology. Endocrinology and metabolism 20020601

• Effect of fiber type and nutritional state on AICAR- and contraction-stimulated glucose transport in rat muscle.

  American journal of physiology. Endocrinology and metabolism 20020601

• Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK).

  Journal of cell science 20020601

• The fixM flavoprotein modulates inhibition by AICAR or 5'AMP of respiratory and nitrogen fixation gene expression in Sinorhizobium meliloti.

  Molecular plant-microbe interactions : MPMI 20020601

• AMP-activated protein kinase kinase: detection with recombinant AMPK alpha1 subunit.

  Biochemical and biophysical research communications 20020510

• Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+).

  American journal of physiology. Endocrinology and metabolism 20020501

• A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes.

  Developmental biology 20020501

• Induction of uncoupling protein 2 mRNA in beta-cells is stimulated by oxidation of fatty acids but not by nutrient oversupply.

  Endocrinology 20020401

• Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells.

  The Biochemical journal 20020401

• Down-regulation of Lsm1 is involved in human prostate cancer progression.

  British journal of cancer 20020318

• An mRNA splice variant of the AFX gene with altered transcriptional activity.

  The Journal of biological chemistry 20020308

• Molecular dissection of alleles of the osmotic-1 locus of Neurospora crassa.

  Fungal genetics and biology : FG & B 20020301

• Effect of AICAR treatment on glycogen metabolism in skeletal muscle.

  Diabetes 20020301

• Regulation of phosphatidylcholine and phosphatidylethanolamine synthesis in rat hepatocytes by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).

  The Biochemical journal 20020215

• Mechanism for fatty acid 'sparing' effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase.

  The Journal of biological chemistry 20020208

• Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle.

  Diabetes 20020201

• 5-amino-4-imidazolecarboxamide riboside confers strong tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent fashion.

  Biochemical and biophysical research communications 20020111

• Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation.

  Diabetes 20020101

• 5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice.

  Diabetologia 20020101

• 5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside.

  The Journal of biological chemistry 20011214

• 5-aminoimidazole-4-carboxy-amide-1-beta-D-ribofuranoside treatment ameliorates hyperglycaemia and hyperinsulinaemia but not dyslipidaemia in KKAy-CETP mice.

  Diabetologia 20011201

• Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase.

  The Journal of biological chemistry 20011102

• AMP-activated protein kinase activation prevents denervation-induced decline in gastrocnemius GLUT-4.

  Journal of applied physiology (Bethesda, Md. : 1985) 20011101

• Penetration of dacarbazine and its active metabolite 5-aminoimidazole-4-carboxamide into cutaneous metastases of human malignant melanoma.

  Cancer 20011015

• Role of AMP-activated protein kinase in mechanism of metformin action.

  The Journal of clinical investigation 20011015

• Regulation of myocardial fatty acid oxidation by substrate supply.

  American journal of physiology. Heart and circulatory physiology 20011001

• Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line.

  Biochemical and biophysical research communications 20010921

• A facile synthesis of [N1,NH(2-)(15)N(2)], [N3,NH(2-)(15)N(2)] and [N2, N3,NH(2-)(15)N(3)]-labeled adenine.

  The Journal of organic chemistry 20010921

• The effects of AICAR on adipocyte differentiation of 3T3-L1 cells.

  Biochemical and biophysical research communications 20010907

• Effect of iprodione, a dicarboximide fungicide, on primary cultured rainbow trout (Oncorhynchus mykiss) hepatocytes.

  Aquatic toxicology (Amsterdam, Netherlands) 20010901

• Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase.

  Journal of applied physiology (Bethesda, Md. : 1985) 20010901

• Stir bar sorptive extraction applied to the determination of dicarboximide fungicides in wine.

  Journal of chromatography. A 20010831

• Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR.

  American journal of physiology. Endocrinology and metabolism 20010801

• AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation.

  Journal of molecular neuroscience : MN 20010801

• Calculation of relative binding free energy differences for fructose 1,6-bisphosphatase inhibitors using the thermodynamic cycle perturbation approach.

  Journal of the American Chemical Society 20010704

• Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase.

  Diabetes 20010701

• Activation of acetyl-CoA carboxylase by a glutamate- and magnesium-sensitive protein phosphatase in the islet beta-cell.

  Diabetes 20010701

• Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells.

  Circulation research 20010622

• Effects of stimulation of AMP-activated protein kinase on insulin-like growth factor 1- and epidermal growth factor-dependent extracellular signal-regulated kinase pathway.

  The Journal of biological chemistry 20010601

• Combination therapy that targets secondary pulmonary changes after abdominal trauma.

  Shock (Augusta, Ga.) 20010601

• Evaluation of the catalytic mechanism of AICAR transformylase by pH-dependent kinetics, mutagenesis, and quantum chemical calculations.

  Journal of the American Chemical Society 20010523

• Determination of dichloroanilines in human urine by GC-MS, GC-MS-MS, and GC-ECD as markers of low-level pesticide exposure.

  Journal of chromatography. B, Biomedical sciences and applications 20010505

• AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle.

  American journal of physiology. Endocrinology and metabolism 20010501

• Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats.

  Diabetes 20010501

• Characterization of mutations in the two-component histidine kinase gene that confer fludioxonil resistance and osmotic sensitivity in the os-1 mutants of Neurospora crassa.

  Pest management science 20010501

• Insulin and contraction directly stimulate UCP2 and UCP3 mRNA expression in rat skeletal muscle in vitro.

  Biochemical and biophysical research communications 20010427

• Stimulation of IGF-binding protein-1 secretion by AMP-activated protein kinase.

  Biochemical and biophysical research communications 20010420

• Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK.

  The Biochemical journal 20010415

• Acute exposure to AICAR increases glucose transport in mouse EDL and soleus muscle.

  Biochemical and biophysical research communications 20010413

• A purine-related metabolite negatively regulates fixNOQP expression in Sinorhizobium meliloti by modulation of fixK expression.

  Molecular plant-microbe interactions : MPMI 20010401

• Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity.

  The Journal of biological chemistry 20010316

• The protective effect of acadesine on lung ischemia-reperfusion injury.

  Anesthesia and analgesia 20010301

• The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes.

  FEBS letters 20010202

• Chronic treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner.

  Diabetes 20010101

• Nitrogen-dependent accumulation of cytokinins in root and the translocation to leaf: implication of cytokinin species that induces gene expression of maize response regulator.

  Plant & cell physiology 20010101

• Isonucleosides incorporating universal bases.

  Nucleosides, nucleotides & nucleic acids 20010101

• Effect of 5-aminoimidazole-4-carboxamide riboside (AICA-r) on isolated thoracic aorta responses in streptozotocin-diabetic rats.

  Journal of basic and clinical physiology and pharmacology 20010101

• Effect of some compounds on the decay of strawberry fruits caused by Botrytis cinerea Pers.

  Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen) 20010101

• Clinical, biochemical and molecular genetic correlations in adenylosuccinate lyase deficiency.

  Human molecular genetics 20000901

• Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase.

  Biochemistry 19990309

• Acadesine: a unique cardioprotective agent for myocardial ischemia.

  Heart disease (Hagerstown, Md.) 19990101

• AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle.

  The American journal of physiology 19971201

• Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii.

  Biochemical pharmacology 19951109

• Acadesine: a new drug that may improve myocardial protection in coronary artery bypass grafting. Results of the first international multicenter study. Multinational Acadesine Study Group.

  The Journal of thoracic and cardiovascular surgery 19951001

• Degradation of iprodione by a soil Arthrobacter-like strain.

  Applied and environmental microbiology 19950901

• 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

  European journal of biochemistry 19950415

• Carboxylases in de novo purine biosynthesis. Characterization of the Gallus gallus bifunctional enzyme.

  Biochemistry 19941004

• N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli.

  Biochemistry 19940301

• Acadesine (AICA-riboside): disposition and metabolism of an adenosine-regulating agent.

  Journal of clinical pharmacology 19931001

• Detection of 5'-phosphoribosyl-4-(N-succinylcarboxamide)-5-aminoimidazole in urine by use of the Bratton-Marshall reaction: identification of patients deficient in adenylosuccinate lyase activity.

  Analytical biochemistry 19860701

• An infantile autistic syndrome characterised by the presence of succinylpurines in body fluids.

  Lancet (London, England) 19841110

• Disruption of AMPKalpha1 signaling prevents AICAR-induced inhibition of AS160/TBC1D4 phosphorylation and glucose uptake in primary rat adipocytes.

  Molecular endocrinology (Baltimore, Md.)