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Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: A pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF-κB signalling pathway modulation.
Toxicology and applied pharmacology 20180801
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Global gene expression profiles in brain regions reflecting abnormal neuronal and glial functions targeting myelin sheaths after 28-day exposure to cuprizone in rats.
Toxicology and applied pharmacology 20161101
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Developmental cuprizone exposure impairs oligodendrocyte lineages differentially in cortical and white matter tissues and suppresses glutamatergic neurogenesis signals and synaptic plasticity in the hippocampal dentate gyrus of rats.
Toxicology and applied pharmacology 20160101
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Cuprizone decreases intermediate and late-stage progenitor cells in hippocampal neurogenesis of rats in a framework of 28-day oral dose toxicity study.
Toxicology and applied pharmacology 20150915
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Developmental exposure to cuprizone reduces intermediate-stage progenitor cells and cholinergic signals in the hippocampal neurogenesis in rat offspring.
Toxicology letters 20150505
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Enhanced accumulation of Kir4.1 protein, but not mRNA, in a murine model of cuprizone-induced demyelination.
Brain research 20131106
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Sildenafil (Viagra®) down regulates cytokines and prevents demyelination in a cuprizone-induced MS mouse model.
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Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination.
Acta neuropathologica 20120901
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Quetiapine enhances oligodendrocyte regeneration and myelin repair after cuprizone-induced demyelination.
Schizophrenia research 20120601
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The cyclooxygenase-2 pathway via the PGE₂ EP2 receptor contributes to oligodendrocytes apoptosis in cuprizone-induced demyelination.
Journal of neurochemistry 20120501
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BACE1 in central nervous system myelination revisited.
Molecular psychiatry 20120301
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Expression of retinoid X receptor β is induced in astrocytes during corpus callosum demyelination.
Journal of chemical neuroanatomy 20120301
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Olesoxime accelerates myelination and promotes repair in models of demyelination.
Annals of neurology 20120201
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Magnetic resonance imaging and histological evidence for the blockade of cuprizone-induced demyelination in C57BL/6 mice.
Neuroscience 20120127
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Fibroblast growth factor 1 (FGFR1) modulation regulates repair capacity of oligodendrocyte progenitor cells following chronic demyelination.
Neurobiology of disease 20120101
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Galanin transgenic mice with elevated circulating galanin levels alleviate demyelination in a cuprizone-induced MS mouse model.
PloS one 20120101
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Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo.
Molecular and cellular neurosciences 20110901
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The hippocampal fimbria of cuprizone-treated animals as a structure for studying neuroprotection in multiple sclerosis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110801
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Corticosteroids impair remyelination in the corpus callosum of cuprizone-treated mice.
Journal of neuroendocrinology 20110701
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Time-dependent changes in the brain arachidonic acid cascade during cuprizone-induced demyelination and remyelination.
Prostaglandins, leukotrienes, and essential fatty acids 20110701
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Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage.
Prostaglandins, leukotrienes, and essential fatty acids 20110701
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Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110501
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Remyelination is altered by bone morphogenic protein signaling in demyelinated lesions.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20110323
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Longitudinal near-infrared imaging of myelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20110216
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Gas6 increases myelination by oligodendrocytes and its deficiency delays recovery following cuprizone-induced demyelination.
PloS one 20110101
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Spatial and temporal profiles of growth factor expression during CNS demyelination reveal the dynamics of repair priming.
PloS one 20110101
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Dietary vitamin D3 supplements reduce demyelination in the cuprizone model.
PloS one 20110101
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Influence of methylprednisolone on magnetic resonance and histological measures during cuprizone-induced demyelination.
Neuroscience letters 20101008
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Modulation of bone morphogenic protein signalling alters numbers of astrocytes and oligodendroglia in the subventricular zone during cuprizone-induced demyelination.
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Beneficial effects of minocycline on cuprizone induced cortical demyelination.
Neurochemical research 20100901
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Cuprizone neurotoxicity, copper deficiency and neurodegeneration.
Neurotoxicology 20100901
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17beta-estradiol protects male mice from cuprizone-induced demyelination and oligodendrocyte loss.
Neurobiology of disease 20100801
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ADAM12 is expressed by astrocytes during experimental demyelination.
Brain research 20100422
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HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage.
Nature neuroscience 20100201
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Effects of fumaric acids on cuprizone induced central nervous system de- and remyelination in the mouse.
PloS one 20100101
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GAS6 enhances repair following cuprizone-induced demyelination.
PloS one 20100101
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Demyelination in the juvenile period, but not in adulthood, leads to long-lasting cognitive impairment and deficient social interaction in mice.
Progress in neuro-psychopharmacology & biological psychiatry 20090831
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17beta-estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice.
Glia 20090601
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Partial inhibition of proteasome activity enhances remyelination after cuprizone-induced demyelination.
Experimental neurology 20090601
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Discoidin domain receptor 1, a tyrosine kinase receptor, is upregulated in an experimental model of remyelination and during oligodendrocyte differentiation in vitro.
Journal of molecular neuroscience : MN 20090501
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Statin therapy inhibits remyelination in the central nervous system.
The American journal of pathology 20090501
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Behavioral and neurobiological changes in C57BL/6 mice exposed to cuprizone.
Behavioral neuroscience 20090401
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Recovery from chronic demyelination by thyroid hormone therapy: myelinogenesis induction and assessment by diffusion tensor magnetic resonance imaging.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20081224
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Activation of inflammatory response by a combination of growth factors in cuprizone-induced demyelinated brain leads to myelin repair.
Neurochemical research 20081201
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Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse.
Schizophrenia research 20081201
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Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity.
Brain research 20081113
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Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency.
Nature neuroscience 20080901
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Thyroid hormones promote differentiation of oligodendrocyte progenitor cells and improve remyelination after cuprizone-induced demyelination.
Experimental neurology 20080801
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Inhibition of p53 transcriptional activity: a potential target for future development of therapeutic strategies for primary demyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20080611
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Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20080514
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MRI identification of the rostral-caudal pattern of pathology within the corpus callosum in the cuprizone mouse model.
Journal of magnetic resonance imaging : JMRI 20080301
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Effects of acute and repeated exposure to lipopolysaccharide on cytokine and corticosterone production during remyelination.
Brain, behavior, and immunity 20071001
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Microglial recruitment, activation, and proliferation in response to primary demyelination.
The American journal of pathology 20070501
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The neurotoxic effect of cuprizone on oligodendrocytes depends on the presence of pro-inflammatory cytokines secreted by microglia.
Neurochemical research 20070201
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Combination of growth factors enhances remyelination in a cuprizone-induced demyelination mouse model.
Neurochemical research 20070101
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Implications of protease M/neurosin in myelination during experimental demyelination and remyelination.
Neuroscience letters 20060925
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A novel fluorescent probe that is brain permeable and selectively binds to myelin.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20060901
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Imaging the peripheral benzodiazepine receptor response in central nervous system demyelination and remyelination.
Toxicological sciences : an official journal of the Society of Toxicology 20060601
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Dominant-negative beta1 integrin mice have region-specific myelin defects accompanied by alterations in MAPK activity.
Glia 20060601
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Remyelination after cuprizone-induced demyelination in the rat is stimulated by apotransferrin.
Experimental neurology 20060401
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Copper and zinc dismetabolism in the mouse brain upon chronic cuprizone treatment.
Cellular and molecular life sciences : CMLS 20050701
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Astroglial-derived lymphotoxin-alpha exacerbates inflammation and demyelination, but not remyelination.
Glia 20050101
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Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis.
The Journal of biological chemistry 20041231
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bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.
Science (New York, N.Y.) 20041217
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Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3.
Journal of Alzheimer's disease : JAD 20041201
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K+ channel blockade impairs remyelination in the cuprizone model.
Glia 20041101
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Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization.
Brain : a journal of neurology 20040601
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Oligodendrocytes and progenitors become progressively depleted within chronically demyelinated lesions.
The American journal of pathology 20040501
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Alterations in metabolism and gene expression in brain regions during cuprizone-induced demyelination and remyelination.
Journal of neurochemistry 20020701
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The protective role of nitric oxide in a neurotoxicant-induced demyelinating model.
Journal of immunology (Baltimore, Md. : 1950) 20020101
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Cuprizone and piperonyl butoxide, proposed inhibitors of T-cell function, attenuate experimental allergic encephalomyelitis in SJL mice.
Journal of neuroimmunology 20011001
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Interleukin-1beta promotes repair of the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20010915
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Cerebroside synthesis as a measure of the rate of remyelination following cuprizone-induced demyelination in brain.
Journal of neurochemistry 20010501
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Role of copper ions and cytochrome P450 in the vasodilator actions of the nitroxyl anion generator, Angeli's salt, on rat aorta.
European journal of pharmacology 20010202
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[Transition metals and nitric oxide production in human endothelial cells].
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie 20010101
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A comparison of spongiosis induced in the brain by hexachlorophene, cuprizone and triethyl tin in the Sprague-Dawley rat.
Human & experimental toxicology 19911101
