370-86-5 | Fccp

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$7.00	$5.00
10mg	98%	in stock	$16.00	$11.00
50mg	>98%(GC)	in stock	$63.00	$45.00
250mg	98%	in stock	$71.00	$50.00
1g	98%	in stock	$175.00	$122.00

Description

• Catalog Number: AI68671
• Chemical Name: Fccp
• CAS Number: 370-86-5
• Molecular Formula: C10H5F3N4O
• Molecular Weight: 254.1681
• MDL Number: MFCD00009699
• SMILES: N#CC(=NNc1ccc(cc1)OC(F)(F)F)C#N

Computed Properties

• Complexity: 388
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• XLogP3: 3.7

Literature

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  The Journal of biological chemistry 20060414

• Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis.

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• Aging-related changes of intracellular Ca2+ stores and contractile response of intestinal smooth muscle.

  Experimental gerontology 20060101

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• Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions.

  Neurobiology of disease 20051201

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  Diabetes & metabolism 20051101

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  European journal of pharmacology 20050822

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  Toxicology letters 20050814

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  Electrophoresis 20050801

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  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050713

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  Neuroscience letters 20050603

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  American journal of physiology. Renal physiology 20050601

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  Neurochemistry international 20050601

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  The Journal of biological chemistry 20050513

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  FEMS microbiology ecology 20050301

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  Biochemistry. Biokhimiia 20050201

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  Glia 20050101

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  Biofizika 20050101

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  FEBS letters 20041217

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  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20041001

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  Brain research 20040813

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  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040801

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  Biochemistry 20040713

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  The European journal of neuroscience 20040701

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  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20040701

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  The Biochemical journal 20040515

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  European journal of biochemistry 20040501

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  Neurochemistry international 20040401

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  The Journal of physiology 20040401

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  Neuropharmacology 20040301

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  Acta pharmacologica Sinica 20040301

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  Neurobiology of aging 20040301

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  American journal of physiology. Cell physiology 20040201

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  The Journal of biological chemistry 20040102

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  Brain research 20031212

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  Biochemistry. Biokhimiia 20031201

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  FEBS letters 20031120

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  Human reproduction (Oxford, England) 20031101

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  Environmental microbiology 20031101

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  American journal of physiology. Cell physiology 20031001

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  Journal of inorganic biochemistry 20031001

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  Journal of neurochemistry 20030901

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  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030827

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  The Journal of physiology 20030815

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  The Biochemical journal 20030701

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  Toxicological sciences : an official journal of the Society of Toxicology 20030601

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  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20030401

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  The Journal of nutritional biochemistry 20030401

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  The Journal of biological chemistry 20030321

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  The Journal of physiology 20030301

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  The Journal of clinical investigation 20030301

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  Cell death and differentiation 20030301

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  Journal of immunology (Baltimore, Md. : 1950) 20030215

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  Life sciences 20030214

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  Development (Cambridge, England) 20030201

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  Journal of cell science 20030201

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  American journal of physiology. Renal physiology 20030201

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  Physiological research 20030101

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  Diabetes technology & therapeutics 20030101

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  Zhurnal evoliutsionnoi biokhimii i fiziologii 20030101

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  Advances in experimental medicine and biology 20030101

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  Journal of neurotrauma 20021201

• High-throughput measurement of mitochondrial membrane potential in a neural cell line using a fluorescence plate reader.

  Biochemical and biophysical research communications 20021115

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  The Analyst 20021101

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  Biochemistry. Biokhimiia 20021101

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  Molecular medicine (Cambridge, Mass.) 20021101

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  American journal of physiology. Cell physiology 20021001

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  Pflugers Archiv : European journal of physiology 20021001

• Differential sensitivity of inward rectifier K+ channels to metabolic inhibitors.

  The Journal of biological chemistry 20020927

• Role of Hsp70 (DnaK-DnaJ-GrpE) and Hsp100 (ClpA and ClpB) chaperones in refolding and increased thermal stability of bacterial luciferases in Escherichia coli cells.

  Biochemistry. Biokhimiia 20020901

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  Respiratory physiology & neurobiology 20020801

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  Diabetes 20020801

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  Journal of neurophysiology 20020801

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  Antioxidants & redox signaling 20020801

• Development of a high throughput screening assay for mitochondrial membrane potential in living cells.

  Journal of biomolecular screening 20020801

• Intracellular distribution of the fluorescent dye nonyl acridine orange responds to the mitochondrial membrane potential: implications for assays of cardiolipin and mitochondrial mass.

  Journal of neurochemistry 20020701

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  Neurobiology of disease 20020701

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  Pflugers Archiv : European journal of physiology 20020501

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  Pflugers Archiv : European journal of physiology 20020501

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  The Journal of biological chemistry 20020419

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  Molecular pharmacology 20020301

• Mitochondrial Ca(2+) buffering regulates synaptic transmission between retinal amacrine cells.

  Journal of neurophysiology 20020301

• NMDA-induced calcium loads recycle across the mitochondrial inner membrane of hippocampal neurons in culture.

  Journal of neurophysiology 20020201

• Modulation of apoptosis by mitochondrial uncouplers: apoptosis-delaying features despite intrinsic cytotoxicity.

  Biochemical pharmacology 20020201

• Mitochondria regulate Ca2+ wave initiation and inositol trisphosphate signal transduction in oligodendrocyte progenitors.

  Journal of neurochemistry 20020201

• Anacardic acid-mediated changes in membrane potential and pH gradient across liposomal membranes.

  Biochimica et biophysica acta 20020102

• FCCP depolarizes plasma membrane potential by activating proton and Na+ currents in bovine aortic endothelial cells.

  Pflugers Archiv : European journal of physiology 20020101

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  Neuroscience 20020101

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  The Journal of eukaryotic microbiology 20020101

• A conserved inhibitory and differential stimulatory action of nucleotides on K(IR)6.0/SUR complexes is essential for excitation-metabolism coupling by K(ATP) channels.

  The Journal of biological chemistry 20011228

• The contributions of plasma membrane Na+-Ca2+-exchange and the Ca2+-ATPase to the regulation of cytosolic calcium ([Ca2+]i) in a clonal pituitary cell line (AtT-20) of mouse corticotropes.

  Life sciences 20011228

• Suramin inhibits respiration and induces membrane permeability transition in isolated rat liver mitochondria.

  Toxicology 20011201

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  Cell calcium 20011201

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  Biochemical Society transactions 20011101

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  Toxicology and applied pharmacology 20011101

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  Zygote (Cambridge, England) 20011101

• Amiloride derivatives are potent blockers of KATP channels.

  Naunyn-Schmiedeberg's archives of pharmacology 20011001

• Ethylazinphos interaction with membrane lipid organization induces increase of proton permeability and impairment of mitochondrial bioenergetic functions.

  Toxicology and applied pharmacology 20010915

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  FEBS letters 20010914

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  Cell death and differentiation 20010901

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  The Journal of biological chemistry 20010831

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  The Journal of pharmacology and experimental therapeutics 20010801

• Development and application of a self-referencing glucose microsensor for the measurement of glucose consumption by pancreatic beta-cells.

  Analytical chemistry 20010801

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  British journal of pharmacology 20010701

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  Life sciences 20010601

• ATP synthesis is coupled to rat liver mitochondrial RNA synthesis.

  Molecular and cellular biochemistry 20010501

• Induction of cyclosporin A-sensitive pore in mitochondria of intact neurons during uncoupling of oxidative phosphorylation.

  Bulletin of experimental biology and medicine 20010501

• The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ.

  The Journal of biological chemistry 20010413

• Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo).

  European journal of pharmacology 20010413

• Photoreducible high spin iron electron paramagnetic resonance signals in dark-adapted Photosystem II: are they oxidised non-haem iron formed from interaction of oxygen with PSII electron acceptors?

  Biochimica et biophysica acta 20010402

• Activation of K+ channels induces apoptosis in vascular smooth muscle cells.

  American journal of physiology. Cell physiology 20010401

• A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons.

  Journal of neurochemistry 20010401

• Carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP) induces initiation factor 2 alpha phosphorylation and translation inhibition in PC12 cells.

  FEBS letters 20010309

• N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx.

  Journal of neuroscience research 20010301

• Calcium-magnesium interactions in pancreatic acinar cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010301

• The effects of singlet oxygen produced by photodynamic action on the mitochondrial permeability transition differ in accordance with the localization of the sensitizer.

  Archives of biochemistry and biophysics 20010215

• Nucleotide effects on liver and muscle mitochondrial non-phosphorylating respiration and membrane potential.

  Biochimica et biophysica acta 20010119

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  Journal of neuroscience methods 20010115

• Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin.

  Cancer research 20010115

• Increased sensitivity of mitochondrial respiration to inhibition by nitric oxide in cardiac hypertrophy.

  Journal of molecular and cellular cardiology 20010101

• Release of calcium from mitochondrial and nonmitochondrial intracellular stores in mouse pancreatic acinar cells by hydrogen peroxide.

  The Journal of membrane biology 20010101

• Regulation of cyclosporin A sensitive mitochondrial permeability transition by the redox state of pyridine nucleotides.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20010101

• Targeting of reporter molecules to mitochondria to measure calcium, ATP, and pH.

  Methods in cell biology 20010101

• Gene therapy with sodium/iodide symporter in hepatocarcinoma.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20010101

• The excitatory effect of nitric oxide on carotid body chemoreception is blocked by oligomycin.

  Advances in experimental medicine and biology 20010101

• The synthesis and antibacterial activity of totarol derivatives. Part 3: Modification of ring-B.

  Bioorganic & medicinal chemistry 20000701

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• Expression cloning of a reserpine-sensitive vesicular monoamine transporter.

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