37248-47-8 | Validamycin

Packsize	Purity	Availability	Price	Discounted Price
25g	60+%	in stock	$10.00	$7.00

Description

• Catalog Number: AD39564
• Chemical Name: Validamycin
• CAS Number: 37248-47-8
• Molecular Formula: C20H35NO13
• Molecular Weight: 497.4908
• MDL Number: MFCD09028089
• SMILES: OC[C@H]1C[C@H](N[C@H]2C=C(CO)[C@H]([C@@H]([C@H]2O)O)O)[C@@H]([C@H]([C@@H]1O[C@@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O)O)O

Computed Properties

• Complexity: 697
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 14
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 14
• Hydrogen Bond Donor Count: 12
• Rotatable Bond Count: 7
• XLogP3: -6.3

Literature

• Temperature shift-induced reactive oxygen species enhanced validamycin A production in fermentation of Streptomyces hygroscopicus 5008.

  Bioprocess and biosystems engineering 20121001

• Impact of nitrogen concentration on validamycin A production and related gene transcription in fermentation of Streptomyces hygroscopicus 5008.

  Bioprocess and biosystems engineering 20120901

• Enhancement of validamycin A production by addition of ethanol in fermentation of Streptomyces hygroscopicus 5008.

  Bioresource technology 20120601

• Enhanced production of trehalose in Escherichia coli by homologous expression of otsBA in the presence of the trehalase inhibitor, validamycin A, at high osmolarity.

  Journal of bioscience and bioengineering 20120201

• Structural and functional analysis of validoxylamine A 7'-phosphate synthase ValL involved in validamycin A biosynthesis.

  PloS one 20120101

• Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: notable effects of the sugar moiety.

  Bioorganic & medicinal chemistry letters 20111201

• Over-expression of UDP-glucose pyrophosphorylase increases validamycin A but decreases validoxylamine A production in Streptomyces hygroscopicus var. jinggangensis 5008.

  Metabolic engineering 20111101

• Nematicidal and antifungal activities of annonaceous acetogenins from Annona squamosa against various plant pathogens.

  Journal of agricultural and food chemistry 20111026

• Inhibition of trehalose breakdown increases new carbon partitioning into cellulosic biomass in Nicotiana tabacum.

  Carbohydrate research 20110401

• Enhanced production of validamycin A by H2O2-induced reactive oxygen species in fermentation of Streptomyces hygroscopicus 5008.

  Bioresource technology 20110101

• Simultaneous determination of substrate and product in the process of preparation of valienamine by capillary zone electrophoresis.

  Journal of separation science 20100701

• Validamycin A improves the response of Medicago truncatula plants to salt stress by inducing trehalose accumulation in the root nodules.

  Journal of plant physiology 20090715

• Effect of fermentation temperature on validamycin A production by Streptomyces hygroscopicus 5008.

  Journal of biotechnology 20090715

• Antifungal activity of CHE-23C, a dimeric sesquiterpene from Chloranthus henryi.

  Journal of agricultural and food chemistry 20090708

• Catalytic analysis of the validamycin glycosyltransferase (ValG) and enzymatic production of 4''-epi-validamycin A.

  Journal of natural products 20080701

• Glucoamylase gene, vldI, is linked to validamycin biosynthesis in Streptomyces hygroscopicus var. limoneus, and vldADEFG confers validamycin production in Streptomyces lividans, revealing the role of VldE in glucose attachment.

  Gene 20070615

• ValC, a new type of C7-Cyclitol kinase involved in the biosynthesis of the antifungal agent validamycin A.

  Chembiochem : a European journal of chemical biology 20070416

• Isolation and identification of a novel valienamine-producing bacterium.

  Journal of applied microbiology 20070301

• Molecular basis for trehalase inhibition revealed by the structure of trehalase in complex with potent inhibitors.

  Angewandte Chemie (International ed. in English) 20070101

• Identification of genes necessary for jinggangmycin biosynthesis from Streptomyces hygroscopicus 10-22.

  Antonie van Leeuwenhoek 20060701

• Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A.

  Chemistry & biology 20060401

• Preparation of trehalase inhibitor validoxylamine A by biocatalyzed hydrolysis of validamycin A with honeybee (Apis cerana Fabr.) beta-glucosidase.

  Applied biochemistry and biotechnology 20051201

• Quantitative analysis of valienamine in the microbial degradation of validamycin A after derivatization with p-nitrofluorobenzene by reversed-phase high-performance liquid chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925

• Physiological implications of trehalase from Phaseolus vulgaris root nodules: partial purification and characterization.

  Plant physiology and biochemistry : PPB 20050401

• Degradation of trehalose by rhizobia and characteristics of a trehalose-degrading enzyme isolated from Rhizobium species NGR234.

  Journal of applied microbiology 20040101

• Determination of the fungicide validamycin A by capillary zone electrophoresis with indirect UV detection.

  Journal of agricultural and food chemistry 20031217

• Determination of lignocaine and amprolium in pharmaceutical formulations using AAS.

  Journal of pharmaceutical and biomedical analysis 20020101

• Synthesis of 5-epi-[6-(2)H(2)]valiolone and stereospecifically monodeuterated 5-epi-valiolones: exploring the steric course of 5-epi-valiolone dehydratase in validamycin A biosynthesis.

  The Journal of organic chemistry 20010727

• Biosynthesis of the validamycins: identification of intermediates in the biosynthesis of validamycin A by Streptomyces hygroscopicus var. limoneus.

  Journal of the American Chemical Society 20010328

• The biosynthesis of acarbose and validamycin.

  Chemical record (New York, N.Y.) 20010101