37835-54-4 | 1-(1-Methylpiperidin-4-yl)ethanol

Packsize	Purity	Availability	Price	Discounted Price
50mg	95%	1 week	$265.00	$185.00
100mg	95%	1 week	$354.00	$248.00
250mg	95%	1 week	$472.00	$331.00
500mg	95%	1 week	$830.00	$581.00
1g	95%	1 week	$1,081.00	$757.00

Description

• Catalog Number: AF86901
• Chemical Name: 1-(1-Methylpiperidin-4-yl)ethanol
• CAS Number: 37835-54-4
• Molecular Formula: C8H17NO
• Molecular Weight: 143.22668000000002
• MDL Number: MFCD12183773
• SMILES: CN1CCC(CC1)C(O)C

Upstream Synthesis Route

The synthetic route for 1-(1-Methylpiperidin-4-yl)ethanol can be achieved through several steps starting from basic building blocks such as 1-methylpiperidin-4-one and ethyl magnesium bromide:

1. Preparation of Grignard Reagent: Ethyl magnesium bromide is prepared by reacting ethyl bromide with magnesium turnings in dry ether, under inert atmosphere at low temperature.

2. Nucleophilic Addition: Then the Grignard reagent (ethyl magnesium bromide) is added to a solution of 1-methylpiperidin-4-one in dry ether, again under an inert atmosphere at low temperature. During this step, nucleophilic addition of the Grignard reagent to the ketone occurs, resulting in the formation of a magnesium alkoxide complex.

3. Acidic Work-Up: The reaction mixture is then subjected to an acidic work-up, typically with dilute hydrochloric acid, to protonate the alkoxide, yielding 1-(1-Methylpiperidin-4-yl)ethanol.

4. Purification: The product is isolated by standard purification techniques such as extraction, drying, and distillation or recrystallization if solid.

In summary, the upstream synthesis of 1-(1-Methylpiperidin-4-yl)ethanol involves the preparation of a Grignard reagent which is then used in a nucleophilic addition to 1-methylpiperidin-4-one, followed by acidic work-up and purification.