38748-32-2 | Triptolide

Packsize	Purity	Availability	Price	Discounted Price
1mg	≥98%	in stock	$42.00	$29.00
5mg	95%	in stock	$91.00	$64.00
25mg	95%	in stock	$246.00	$173.00
100mg	95%	in stock	$718.00	$502.00
250mg	95%	in stock	$1,052.00	$736.00

Description

• Catalog Number: AB47363
• Chemical Name: Triptolide
• CAS Number: 38748-32-2
• Molecular Formula: C20H24O6
• Molecular Weight: 360.4010
• MDL Number: MFCD00210565
• SMILES: O=C1OCC2=C1CC[C@]1([C@H]2C[C@H]2[C@@]3([C@@]41O[C@H]4[C@@H]1O[C@@]1([C@H]3O)C(C)C)O2)C
• NSC Number: 163062

Computed Properties

• Complexity: 819
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 9
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 0.2

Literature

• Triptolide induces p53-dependent cardiotoxicity through mitochondrial membrane permeabilization in cardiomyocytes.

  Toxicology and applied pharmacology 20180915

• Triptolide-induced mitochondrial damage dysregulates fatty acid metabolism in mouse sertoli cells.

  Toxicology letters 20180801

• Characterization of Triptolide-Induced Hepatotoxicity by Imaging and Transcriptomics in a Novel Zebrafish Model.

  Toxicological sciences : an official journal of the Society of Toxicology 20171001

• Triptolide induced cell death through apoptosis and autophagy in murine leukemia WEHI-3 cells in vitro and promoting immune responses in WEHI-3 generated leukemia mice in vivo.

  Environmental toxicology 20170201

• Suppression of the migration and invasion is mediated by triptolide in B16F10 mouse melanoma cells through the NF-kappaB-dependent pathway.

  Environmental toxicology 20161201

• Triptolide disrupts the actin-based Sertoli-germ cells adherens junctions by inhibiting Rho GTPases expression.

  Toxicology and applied pharmacology 20161101

• Protection of Quercetin against Triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells.

  Chemico-biological interactions 20151005

• Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury: A GC-MS based metabolomics study.

  Toxicology 20151002

• Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice.

  Scientific reports 20150101

• Triptolide-induced oxidative stress involved with Nrf2 contribute to cardiomyocyte apoptosis through mitochondrial dependent pathways.

  Toxicology letters 20141104

• Interleukin-17 mediates triptolide-induced liver injury in mice.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140901

• Metabolic pathways leading to detoxification of triptolide, a major active component of the herbal medicine Tripterygium wilfordii.

  Journal of applied toxicology : JAT 20140801

• Establishment of hypoxia induction in an in vivo animal replacement model for experimental evaluation of pancreatic cancer.

  Oncology reports 20140701

• FSL-1 induces MMP-9 production through TLR-2 and NF-κB /AP-1 signaling pathways in monocytic THP-1 cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20140101

• Gene expression profiling and pathway analysis of hepatotoxicity induced by triptolide in Wistar rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130801

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• NF-κB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model.

  International journal of cancer 20121115

• Identification of in vivo and in vitro metabolites of triptolide by liquid chromatography-tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20121101

• Anti-inflammatory effects of mapracorat, a novel selective glucocorticoid receptor agonist, is partially mediated by MAP kinase phosphatase-1 (MKP-1).

  The Journal of biological chemistry 20121012

• Triptolide modulates the sensitivity of K562/A02 cells to adriamycin by regulating miR-21 expression.

  Pharmaceutical biology 20121001

• Biological activity and safety of Tripterygium extract prepared by sodium carbonate extraction.

  Molecules (Basel, Switzerland) 20120917

• Role of Nrf2 in protection against triptolide-induced toxicity in rat kidney cells.

  Toxicology letters 20120903

• Triptolide in the treatment of psoriasis and other immune-mediated inflammatory diseases.

  British journal of clinical pharmacology 20120901

• Triptolide triggers the apoptosis of pancreatic cancer cells via the downregulation of Decoy receptor 3 expression.

  Journal of cancer research and clinical oncology 20120901

• Triptolide regulates T cell-mediated immunity via induction of CD11c(low) dendritic cell differentiation.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120701

• In vitro and in vivo evaluation of Triptolide-loaded pluronic P105 polymeric micelles.

  Arzneimittel-Forschung 20120701

• Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo.

  Cancer letters 20120628

• Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14-3-3 epsilon.

  Cell biochemistry and function 20120601

• Effects of triptolide on the synaptophysin expression of hippocampal neurons in the AD cellular model.

  International immunopharmacology 20120601

• Effect of triptolide on T-cell receptor beta variable gene mRNA expression in rats with collagen-induced arthritis.

  Anatomical record (Hoboken, N.J. : 2007) 20120601

• Effect of triptolide on progesterone production from cultured rat granulosa cells.

  Arzneimittel-Forschung 20120601

• Activation of apoptosis signaling eliminates CD34+ progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors.

  Leukemia 20120401

• MKP-1: a negative feedback effector that represses MAPK-mediated pro-inflammatory signaling pathways and cytokine secretion in human airway smooth muscle cells.

  Cellular signalling 20120401

• Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms.

  Natural product reports 20120401

• [Effects of triptolide on bortezomib-induced apoptosis in multiple myeloma cells].

  Zhongguo shi yan xue ye xue za zhi 20120401

• Triptolide down-regulates COX-2 expression and PGE2 release by suppressing the activity of NF-κB and MAP kinases in lipopolysaccharide-treated PC12 cells.

  Phytotherapy research : PTR 20120301

• Triptolide attenuate the oxidative stress induced by LPS/D-GalN in mice.

  Journal of cellular biochemistry 20120301

• Intrathecal administration of triptolide, a T lymphocyte inhibitor, attenuates chronic constriction injury-induced neuropathic pain in rats.

  Brain research 20120203

• [Effect of triptolide on sensitivity of K562/A02 cell line to adriamycin].

  Zhongguo shi yan xue ye xue za zhi 20120201

• [Triptolide combined with irbesartan synergistically blocks podocyte injury in a type 2 diabetes rat model].

  Zhonghua nei ke za zhi 20120201

• Triptolide augments the effects of 5-lipoxygenase RNA interference in suppressing pancreatic tumor growth in a xenograft mouse model.

  Cancer chemotherapy and pharmacology 20120101

• Local suppression of pro-inflammatory cytokines and the effects in BMP-2-induced bone regeneration.

  Biomaterials 20120101

• Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B.

  Acta pharmacologica Sinica 20120101

• Effect of triptolide on estradiol release from cultured rat granulosa cells.

  Endocrine journal 20120101

• Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha.

  PloS one 20120101

• Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression.

  PloS one 20120101

• Disseminated cutaneous Kaposi sarcoma in a patient receiving triptolide/tripdiolide for rheumatoid arthritis.

  Medical science monitor : international medical journal of experimental and clinical research 20120101

• Prediction of the pharmacokinetic parameters of triptolide in rats based on endogenous molecules in pre-dose baseline serum.

  PloS one 20120101

• Triptolide inhibits COX-2 expression by regulating mRNA stability in TNF-α-treated A549 cells.

  Biochemical and biophysical research communications 20111209

• Complexation of triptolide and its succinate derivative with cyclodextrins: affinity capillary electrophoresis, isothermal titration calorimetry and 1H NMR studies.

  Journal of chromatography. A 20111202

• Cytotoxicity of Triptolide and Triptolide loaded polymeric micelles in vitro.

  Toxicology in vitro : an international journal published in association with BIBRA 20111201

• Inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury.

  Fitoterapia 20111201

• Triptolide inhibits IFN-γ signaling via the Jak/STAT pathway in HaCaT keratinocytes.

  Phytotherapy research : PTR 20111101

• Effect of triptolide on focal adhesion kinase and survival in MCF-7 breast cancer cells.

  Oncology reports 20111101

• Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.

  Biochemical pharmacology 20111101

• Metabolite identification of triptolide by data-dependent accurate mass spectrometric analysis in combination with online hydrogen/deuterium exchange and multiple data-mining techniques.

  Rapid communications in mass spectrometry : RCM 20111030

• Triptolide protects mice from ischemia/reperfusion injury by inhibition of IL-17 production.

  International immunopharmacology 20111001

• Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity.

  Toxicology letters 20110810

• A high-sensitivity UPLC-MS/MS method for simultaneous determination and confirmation of triptolide in zebrafish embryos.

  Biomedical chromatography : BMC 20110801

• Triptolide directly inhibits dCTP pyrophosphatase.

  Chembiochem : a European journal of chemical biology 20110725

• Antifibrotic effects of triptolide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats.

  Phytotherapy research : PTR 20110701

• Clinical outcomes in children with Henoch-Schönlein purpura nephritis grade IIIa or IIIb.

  Pediatric nephrology (Berlin, Germany) 20110701

• Does triptolide induce lysosomal-mediated apoptosis in human breast cancer cells?

  Medical hypotheses 20110701

• The main anticancer bullets of the Chinese medicinal herb, thunder god vine.

  Molecules (Basel, Switzerland) 20110623

• Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors.

  The Journal of surgical research 20110615

• Triptolide ameliorates Crohn's colitis is associated with inhibition of TLRs/NF-κB signaling pathway.

  Fitoterapia 20110601

• Role of reactive oxygen species in triptolide-induced apoptosis of renal tubular cells and renal injury in rats.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20110601

• Inhibitive effect of triptolide on invasiveness of human fibrosarcoma cells by downregulating matrix metalloproteinase-9 expression.

  Asian Pacific journal of tropical medicine 20110601

• [Modulatory effect of triptolide on differentiation of human Th17 cells].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110601

• Semisynthesis of triptolide analogues: effect of γ-lactone and C-14 substituents on cytotoxic activities.

  Bioorganic & medicinal chemistry letters 20110515

• CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection.

  Journal of immunology (Baltimore, Md. : 1950) 20110515

• Total synthesis of novel D-ring-modified triptolide analogues: structure-cytotoxic activity relationship studies on the D-ring of triptolide.

  Organic & biomolecular chemistry 20110507

• Triptolide inhibits rat vascular smooth muscle cell proliferation and cell cycle progression via attenuation of ERK1/2 and Rb phosphorylation.

  Experimental and molecular pathology 20110401

• Triptolide alleviates hepatic ischemia/reperfusion injury by attenuating oxidative stress and inhibiting NF-κB activity in mice.

  The Journal of surgical research 20110401

• Triptolide-induced cell cycle arrest and apoptosis in human renal cell carcinoma cells.

  Oncology reports 20110401

• Effectiveness of triptolide-coated stent on decreasing inflammation and attenuation of intimal hyperplasia in a pig after coronary angioplasty.

  Angiology 20110401

• Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-κB activity and miR-16-1*.

  Acta pharmacologica Sinica 20110401

• Derivatization of (5R)-hydroxytriptolide from benzylamine to enhance mass spectrometric detection: application to a Phase I pharmacokinetic study in humans.

  Analytica chimica acta 20110309

• The effects of triptolide on airway remodelling and transforming growth factor-β₁/Smad signalling pathway in ovalbumin-sensitized mice.

  Immunology 20110301

• Triptolide and its expanding multiple pharmacological functions.

  International immunopharmacology 20110301

• XPB, a subunit of TFIIH, is a target of the natural product triptolide.

  Nature chemical biology 20110301

• Biologic activity of triptolide in t(8;21) acute myeloid leukemia cells.

  Leukemia research 20110201

• Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway.

  Oncology reports 20110201

• Triptolide attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction.

  Nephrology (Carlton, Vic.) 20110201

• MAPKs are not involved in triptolide-induced cell growth inhibition and apoptosis in prostate cancer cell lines with different p53 status.

  Planta medica 20110101

• Triptolide induces adverse effect on reproductive parameters of female Sprague-Dawley rats.

  Drug and chemical toxicology 20110101

• Therapeutic approach to multiple sclerosis by novel oral drug.

  Recent patents on inflammation & allergy drug discovery 20110101

• In vitro synergistic cytotoxic effect of triptolide combined with hydroxycamptothecin on pancreatic cancer cells.

  The American journal of Chinese medicine 20110101

• Inhibition of tumor cellular proteasome activity by triptolide extracted from the Chinese medicinal plant 'thunder god vine'.

  Anticancer research 20110101

• Inhibition of poly(I:C)-induced matrix metalloproteinase expression in human corneal fibroblasts by triptolide.

  Molecular vision 20110101

• Disappearance of sexual dimorphism in triptolide metabolism in monosodium glutamate treated neonatal rats.

  Arzneimittel-Forschung 20110101

• [Pharmacokinetics of triptolide in Triptergium wilfordii microemulsion gel].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110101

• Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II).

  PloS one 20110101

• Effect of triptolide on aromatase activity in human placental microsomes and human placental JEG-3 cells.

  Arzneimittel-Forschung 20110101

• Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells.

  Experimental & molecular medicine 20101231

• Preparation and anti-inflammatory activity of triptolide ethosomes in an erythema model.

  Journal of liposome research 20101201

• Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells.

  Cancer letters 20101128

• Role of triptolide in cell proliferation, cell cycle arrest, apoptosis and histone methylation in multiple myeloma U266 cells.

  European journal of pharmacology 20101110

• Treatment of db/db diabetic mice with triptolide: a novel therapy for diabetic nephropathy.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20101101

• Transcription factor NF-κB inhibitors as single therapeutic agents or in combination with classical chemotherapeutic agents for the treatment of hematologic malignancies.

  Current molecular pharmacology 20101101

• Synthesis and biological evaluation of novel triptolide analogues for anticancer activity.

  Bioorganic & medicinal chemistry letters 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Triptolide inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway.

  International journal of oncology 20101101

• Triptolide inhibits extracellular matrix protein synthesis by suppressing the Smad2 but not the MAPK pathway in TGF-beta1-stimulated NRK-49F cells.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20101001

• Physio-pathological parameters affect the activation of inflammatory pathways by deoxynivalenol in Caco-2 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20101001

• Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinoma.

  The Journal of surgical research 20101001

• Autophagy in pancreatic cancer: an emerging mechanism of cell death.

  Autophagy 20101001

• Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17.

  Molecular immunology 20100901

• Role of Hsp-70 in triptolide-mediated cell death of neuroblastoma.

  The Journal of surgical research 20100901

• Diastereoselective formal total synthesis of (+/-)-triptolide via a novel cationic cyclization of 2-alkenyl-1,3-dithiolane.

  Chemical communications (Cambridge, England) 20100821

• Triptolide T10 enhances AAV-mediated gene transfer in mice striatum.

  Neuroscience letters 20100802

• Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways.

  Gastroenterology 20100801

• [Effect of triptolide on reversing hypermethylation of apc gene in Jurkat cells and its possible mechanisms].

  Zhongguo shi yan xue ye xue za zhi 20100801

• [Effects of triptolide on hypothalamic-pituitary-adrenal axis of rats].

  Fa yi xue za zhi 20100801

• Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100701

• RNA polymerase - an important molecular target of triptolide in cancer cells.

  Cancer letters 20100628

• Triptolide circumvents drug-resistant effect and enhances 5-fluorouracil antitumor effect on KB cells.

  Anti-cancer drugs 20100601

• Triptolide promotes spinal cord repair by inhibiting astrogliosis and inflammation.

  Glia 20100601

• Identification of triptolide, a natural diterpenoid compound, as an inhibitor of lung inflammation.

  American journal of physiology. Lung cellular and molecular physiology 20100601

• Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro.

  Kidney international 20100601

• Effects of triptolide on RIZ1 expression, proliferation, and apoptosis in multiple myeloma U266 cells.

  Acta pharmacologica Sinica 20100601

• Triptolide prolonged allogeneic islet graft survival in chemically induced and spontaneously diabetic mice without impairment of islet function.

  Hepatobiliary & pancreatic diseases international : HBPD INT 20100601

• [Effects of triptolide-medicated serum on secretion function of adrenocortical cells isolated from rats].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20100601

• Triptolide simultaneously induces reactive oxygen species, inhibits NF-kappaB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines.

  Cancer letters 20100528

• Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1.

  Cancer letters 20100528

• Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats.

  Toxicology 20100430

• Novel anti-inflammatory and neuroprotective agents for Parkinson's disease.

  CNS & neurological disorders drug targets 20100401

• Triptolide inhibits IL-12/IL-23 expression in APCs via CCAAT/enhancer-binding protein alpha.

  Journal of immunology (Baltimore, Md. : 1950) 20100401

• [Effects of triptolide on cell proliferation and regulation of Ras-MAPKs pathway in synoviocytes induced by tumor necrosis factor].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100401

• Design, synthesis, and biological evaluation of novel water-soluble triptolide derivatives: Antineoplastic activity against imatinib-resistant CML cells bearing T315I mutant Bcr-Abl.

  Bioorganic & medicinal chemistry 20100301

• Merging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and functional foods.

  Current drug discovery technologies 20100301

• Targeting tumor proteasome with traditional Chinese medicine.

  Current drug discovery technologies 20100301

• Induction of dual specificity phosphatase 1 (DUSP1) by gonadotropin-releasing hormone (GnRH) and the role for gonadotropin subunit gene expression in mouse pituitary gonadotroph L beta T2 cells.

  Biology of reproduction 20100201

• Effects of cytochrome P4503A inducer dexamethasone on the metabolism and toxicity of triptolide in rat.

  Toxicology letters 20100201

• TRAIL and triptolide: an effective combination that induces apoptosis in pancreatic cancer cells.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20100201

• [Research progress on immunosuppressive activity of monomers extracted from Chinese medicine].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100201

• Triptolide alters histone H3K9 and H3K27 methylation state and induces G0/G1 arrest and caspase-dependent apoptosis in multiple myeloma in vitro.

  Toxicology 20100112

• A facile construction strategy of stable lipid nanoparticles for drug delivery using a hydrogel-thickened microemulsion system.

  Nanotechnology 20100108

• Triptolide functions as a potent angiogenesis inhibitor.

  International journal of cancer 20100101

• Anti-angiogenic activity of triptolide in anaplastic thyroid carcinoma is mediated by targeting vascular endothelial and tumor cells.

  Vascular pharmacology 20100101

• Programmed cell death 5 factor enhances triptolide-induced fibroblast-like synoviocyte apoptosis of rheumatoid arthritis.

  Artificial cells, blood substitutes, and immobilization biotechnology 20100101

• Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide.

  Molecular cancer 20100101

• Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-kappaB/IkappaBalpha transcriptional complex.

  Journal of neuroimmunology 20091210

• Protective and therapeutic effect of triptolide in EAE explained by induction of major stress protein HSP70.

  Journal of neuroimmunology 20091210

• Identification of inhibitors of HSF1 functional activity by high-content target-based screening.

  Journal of biomolecular screening 20091201

• Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-kappaB-related mechanism.

  Oncology reports 20091201

• Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20091101

• Triptolide abrogates oncogene FIP1L1-PDGFRalpha addiction and induces apoptosis in hypereosinophilic syndrome.

  Cancer science 20091101

• Ancient drugs, modern targets.

  Cancer biology & therapy 20091101

• Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells.

  Cancer biology & therapy 20091101

• Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression.

  Experimental & molecular medicine 20091031

• Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA.

  Molecular cancer therapeutics 20091001

• Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells.

  Experimental & molecular medicine 20090930

• Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells.

  Molecular cancer therapeutics 20090901

• Design and synthesis of novel C14-hydroxyl substituted triptolide derivatives as potential selective antitumor agents.

  Journal of medicinal chemistry 20090827

• Triptolide promotes generation of FoxP3+ T regulatory cells in rats.

  Journal of ethnopharmacology 20090817

• Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo.

  Surgery 20090801

• [Advance in the anti-tumor mechanism of triptolide].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090801

• Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo.

  Oral oncology 20090701

• Activity of triptolide against human mast cells harboring the kinase domain mutant KIT.

  Cancer science 20090701

• [Effect of triptolide on the proliferation and apoptosis of human epidermal squamous cell carcinoma cell line A431 in vitro].

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20090701

• [Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20090701

• Caspase 3 is involved in the apoptosis induced by triptolide in HK-2 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20090601

• Possible involvement of mitogen-activated protein kinase phosphatase-1 (MKP-1) in thyrotropin-releasing hormone (TRH)-induced prolactin gene expression.

  Biochemical and biophysical research communications 20090515

• Intermittent counter-current extraction as an alternative approach to purification of Chinese herbal medicine.

  Journal of chromatography. A 20090508

• Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms.

  Gastroenterology 20090501

• Interleukin-6-independent expression of glucocorticoid receptor is upregulated by triptolide in multiple myeloma.

  Leukemia & lymphoma 20090501

• Overcoming glucocorticoid resistance: a new pathway from an ancient Chinese medicine?

  Leukemia & lymphoma 20090501

• Clinical applications of the immunomodulatory properties of triptolide besides in arthritis.

  Scandinavian journal of immunology 20090501

• A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway.

  Molecular pharmacology 20090401

• Inhibiting the transcription factor HSF1 as an anticancer strategy.

  Expert opinion on therapeutic targets 20090401

• Simultaneous determination of triptolide, tripdiolide and tripterine in human urine by high-performance liquid chromatography coupled with ion trap atmospheric-pressure chemical ionization mass spectrometry.

  Biomedical chromatography : BMC 20090301

• The targeting of 14-succinate triptolide-lysozyme conjugate to proximal renal tubular epithelial cells.

  Biomaterials 20090301

• Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090301

• [Suppression of murine EAE by triptolide is related to downregulation of INF-gamma and upregulation of IL-10 secretion in splenic lymphocytes].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20090301

• [Cordyceps sinensis polysaccharide enhances apoptosis of HL-60 cells induced by triptolide].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20090301

• [Triptolide evaluates DNA methylation level of matrix metalloproteinase 9 gene in human fibrosarcoma HT-1080 cells].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090301

• Triptolide and management of systemic malignancies besides pancreatic carcinomas.

  World journal of gastroenterology 20090227

• Antiangiogenic activity of Tripterygium wilfordii and its terpenoids.

  Journal of ethnopharmacology 20090112

• Heat shock protein 72 protects kidney proximal tubule cells from injury induced by triptolide by means of activation of the MEK/ERK pathway.

  International journal of toxicology 20090101

• The effect of triptolide on CD4+ and CD8+ cells in the Peyer's patch of DA rats with collagen induced arthritis.

  Natural product research 20090101

• Therapeutic effects of triptolide on interleukin-10 gene-deficient mice with colitis.

  International immunopharmacology 20081220

• [Overexpression of programmed cell death 5 factor enhances triptolides-induced fibroblast-like synoviocytes apoptosis in rheumatoid arthritis].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20081218

• Triptolide inhibits amyloid-beta1-42-induced TNF-alpha and IL-1beta production in cultured rat microglia.

  Journal of neuroimmunology 20081215

• Preparative separation of a terpenoid and alkaloids from Tripterygium wilfordii Hook. f. using high-performance counter-current chromatography. Comparison of various elution and operating strategies.

  Journal of chromatography. A 20081212

• Triptolide cooperates with chemotherapy to induce apoptosis in acute myeloid leukemia cells.

  Experimental hematology 20081201

• In vivo evaluation of the safety of triptolide-loaded hydrogel-thickened microemulsion.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201

• Characterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomes.

  Xenobiotica; the fate of foreign compounds in biological systems 20081201

• Prolongation of rat intestinal allograft survival by administration of triptolide-modified donor bone marrow-derived dendritic cells.

  Transplantation proceedings 20081201

• [Advances in the study of immunopharmacological effects and mechanisms of extracts of Tripterygium wilfordii Hook. f. in neuroimmunologic disorders].

  Yao xue xue bao = Acta pharmaceutica Sinica 20081201

• Triptolide inhibits interferon-gamma-induced programmed death-1-ligand 1 surface expression in breast cancer cells.

  Cancer letters 20081108

• The suppressive effect of triptolide on chronic colitis and TNF-alpha/TNFR2 signal pathway in interleukin-10 deficient mice.

  Clinical immunology (Orlando, Fla.) 20081101

• Anti-tumour and immuno-modulation effects of triptolide-loaded polymeric micelles.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20081101

• Triptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-kappaB and JNK in LPS-treated microglia.

  Journal of neurochemistry 20081101

• Therapeutic strategies for Parkinson's disease: the ancient meets the future--traditional Chinese herbal medicine, electroacupuncture, gene therapy and stem cells.

  Neurochemical research 20081001

• Triptolide inhibits the differentiation of Th17 cells and suppresses collagen-induced arthritis.

  Scandinavian journal of immunology 20081001

• Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-kappaB pathways in human multiple myeloma cells.

  International journal of molecular medicine 20081001

• Triptolide protects podocytes from puromycin aminonucleoside induced injury in vivo and in vitro.

  Kidney international 20080901

• Triptolide reduces cystogenesis in a model of ADPKD.

  Journal of the American Society of Nephrology : JASN 20080901

• Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis.

  Journal of neuroscience research 20080815

• Cancer-specific enhancement of cisplatin-induced cytotoxicity with triptolide through an interaction of inactivated glycogen synthase kinase-3beta with p53.

  Oncogene 20080731

• Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells.

  European journal of pharmacology 20080728

• Mycophenolate mofetil and triptolide alleviating airway inflammation in asthmatic model mice partly by inhibiting bone marrow eosinophilopoiesis.

  International immunopharmacology 20080701

• Triptolide-induced transcriptional arrest is associated with changes in nuclear substructure.

  Cancer research 20080701

• Effect of poly(D, L-lactic acid) nanoparticles as triptolide carrier on abating rats renal toxicity by NMR-based metabolic analysis.

  Journal of nanoscience and nanotechnology 20080701

• Triptolide protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats: implication for immunosuppressive therapy in Parkinson's disease.

  Neuroscience bulletin 20080601

• Effective therapy for nephritis in (NZB x NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy Tripterygium wilfordii Hook F.

  Arthritis and rheumatism 20080601

• Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080601

• [Effects of triptolide on proliferation and apoptosis of Jurkat cell line in acute T lymphocytic leukemia].

  Zhongguo shi yan xue ye xue za zhi 20080601

• Combined treatment with triptolide and rapamycin prolongs graft survival in a mouse model of cardiac transplantation.

  Transplant international : official journal of the European Society for Organ Transplantation 20080501

• Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5.

  Blood 20080401

• Fluorination of triptolide and its analogues and their cytotoxicity.

  Bioorganic & medicinal chemistry letters 20080401

• Involvement of mitochondrial pathway in triptolide-induced cytotoxicity in human normal liver L-02 cells.

  Biological & pharmaceutical bulletin 20080401

• Formal total synthesis of triptolide.

  Chemical communications (Cambridge, England) 20080314

• Apoptosis of human pancreatic cancer cells induced by Triptolide.

  World journal of gastroenterology 20080314

• [The cornea: stasis and dynamics].

  Nippon Ganka Gakkai zasshi 20080301

• Upregulation of ICAM-1 expression in bronchial epithelial cells by airway secretions in bronchiectasis.

  Respiratory medicine 20080201

• Immunochemical characterization of the functional constituents of Tripterygium wilfordii contributing to its anti-inflammatory property.

  Clinical and experimental pharmacology & physiology 20080101

• Role of triptolide as an adjunct chemotherapy for ovarian cancer.

  Chemotherapy 20080101

• [Male antifertility drugs and cell apoptosis].

  Zhonghua nan ke xue = National journal of andrology 20080101

• Development and validation of a liquid chromatography coupled with atmospheric-pressure chemical ionization ion trap mass spectrometric method for the simultaneous determination of triptolide, tripdiolide, and tripterine in human serum.

  Journal of analytical toxicology 20080101

• Male reproductive toxicity and toxicokinetics of triptolide in rats.

  Arzneimittel-Forschung 20080101

• Triptolide, a component of Chinese herbal medicine, modulates the functional phenotype of dendritic cells.

  Transplantation 20071215

• Triptolide inhibits NF-kappaB activation and reduces injury of donor lung induced by ischemia/reperfusion.

  Acta pharmacologica Sinica 20071201

• Honeybee (Apis cerana) foraging responses to the toxic honey of Tripterygium hypoglaucum (Celastraceae): changing threshold of nectar acceptability.

  Journal of chemical ecology 20071201

• Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

  Cancer research 20071001

• [Effect of triptolide on the expression of matrix metalloproteinases 2 and 9 in lungs of experimental pulmonary hypertension].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20071001

• Molecular understanding and modern application of traditional medicines: triumphs and trials.

  Cell 20070907

• Differential expression and oxidation of MKP-1 modulates TNF-alpha gene expression.

  American journal of respiratory cell and molecular biology 20070901

• Experimental AA amyloidosis in mice is inhibited by treatment with triptolide, a purified traditional Chinese medicine.

  International immunopharmacology 20070901

• [Effect of triptolide on the development of monocrotaline-induced pulmonary hypertension in pneumonectomized rat].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20070901

• Hydrogel-thickened microemulsion for topical administration of drug molecule at an extremely low concentration.

  International journal of pharmaceutics 20070816

• Enhanced antitumor effect of combined triptolide and ionizing radiation.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070815

• Involvement of PDCD5 in the regulation of apoptosis in fibroblast-like synoviocytes of rheumatoid arthritis.

  Apoptosis : an international journal on programmed cell death 20070801

• [Effect of triptolide on airway remodeling and the expression of phosphoinositide 3-kinases in asthmatic rats].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070801

• Gene expression profile analyses of mice livers injured by Leigongteng.

  World journal of gastroenterology 20070714

• Kinetic release of triptolide after injection of renal-targeting 14-succinyl triptolide-lysozyme in a rat kidney study by liquid chromatography/mass spectrometry.

  Biomedical chromatography : BMC 20070701

• Triptolide upregulates NGF synthesis in rat astrocyte cultures.

  Neurochemical research 20070701

• Suppression of 5-lipoxygenase gene is involved in triptolide-induced apoptosis in pancreatic tumor cell lines.

  Biochimica et biophysica acta 20070701

• Triptolide suppresses interleukin-1beta-induced human beta-defensin-2 mRNA expression through inhibition of transcriptional activation of NF-kappaB in A549 cells.

  International journal of molecular medicine 20070501

• Synergistic effect of triptolide combined with 5-fluorouracil on colon carcinoma.

  Postgraduate medical journal 20070501

• [Triptolide-eluting stent prevents porcine coronary artery in-stent restenosis by affecting PCNA and P27(kip1) expression].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070501

• Triptolide impairs dendritic cell migration by inhibiting CCR7 and COX-2 expression through PI3-K/Akt and NF-kappaB pathways.

  Molecular immunology 20070401

• Therapeutic effect of combined triptolide and glycyrrhizin treatment on rats with collagen induced arthritis.

  Planta medica 20070401

• Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii.

  Phytochemistry 20070401

• Pharmacokinetic study of triptolide, a constituent of immunosuppressive chinese herb medicine, in rats.

  Biological & pharmaceutical bulletin 20070401

• [Effects of triptolide on the production of interferon-gamma in human peripheral blood mononuclear cell and phosphorylation of signal transducer and activator of transcription-1 and production of interleukin-8].

  Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20070401

• [Microstructure of novel solid lipid nanoparticle loaded triptolide].

  Yao xue xue bao = Acta pharmaceutica Sinica 20070401

• Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene.

  European journal of pharmacology 20070315

• Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae).

  Phytochemistry 20070301

• [Effects of triptolide on prostate carcinoma in mouse RM-1 cells].

  Zhonghua nan ke xue = National journal of andrology 20070301

• [Effect of combination glycyrrhiizin and triptolide on TNF-alpha and IL-10 in serum of collagen induced arthritis rats].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070301

• Triptolide inhibits cyclooxygenase-2 and inducible nitric oxide synthase expression in human colon cancer and leukemia cells.

  Acta biochimica et biophysica Sinica 20070201

• Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice.

  Biochemical pharmacology 20070101

• The roles of endogenous reactive oxygen species and nitric oxide in triptolide-induced apoptotic cell death in macrophages.

  Journal of molecular medicine (Berlin, Germany) 20070101

• Triptolide suppresses IL-1beta-induced chemokine and stromelysin-1 gene expression in human colonic subepithelial myofibroblasts.

  Acta pharmacologica Sinica 20070101

• [Pharmacokinetics of triptolide in Beagle dogs].

  Yao xue xue bao = Acta pharmaceutica Sinica 20070101

• Triptolide binds covalently to a 90 kDa nuclear protein. Role of epoxides in binding and activity.

  Immunobiology 20070101

• Inhibitory effect of triptolide on glioblastoma multiforme in vitro.

  The Journal of international medical research 20070101

• Triptolide alters mitochondrial functions.

  Advances in experimental medicine and biology 20070101

• The effect of triptolide on apoptosis of glioblastoma multiforme (GBM) cells.

  The Journal of international medical research 20070101

• Triptolide inhibits tumor promoter-induced uPAR expression via blocking NF-kappaB signaling in human gastric AGS cells.

  Anticancer research 20070101

• Triptolide inhibits CCR5 expressed in synovial tissue of rat adjuvant-induced arthritis.

  Pharmacological reports : PR 20070101

• Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis.

  International immunopharmacology 20061205

• Synthesis, characterization and in vitro evaluation of triptolide-lysozyme conjugate for renal targeting delivery of triptolide.

  Archives of pharmacal research 20061201

• [Study on content variation of triptolide in medicinal material of Tripterygium].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201

• Inhibitory effect of triptolide on lymph node metastasis in patients with non-Hodgkin lymphoma by regulating SDF-1/CXCR4 axis in vitro.

  Acta pharmacologica Sinica 20061101

• Effects of triptolide and TNF-alpha on the expression of VEGF in Raji cells and on angiogenesis in ECV304 cells.

  Zhongguo shi yan xue ye xue za zhi 20061001

• [Correlations between diagnostic information and therapeutic efficacy in rheumatoid arthritis analyzed with decision tree model].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20061001

• [Progress in research on mechanisms of anti-rheumatoid arthritis of triptolide].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061001

• Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells.

  Cancer letters 20060908

• Inhibition by triptolide of chemokine, proinflammatory cytokine, and adhesion molecule expression induced by lipopolysaccharide in corneal fibroblasts.

  Investigative ophthalmology & visual science 20060901

• [Protective effects of triptolide on the lipopolysaccharide-mediated degeneration of dopaminergic neurons in substantia nigra].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20060801

• Dipyridamole activation of mitogen-activated protein kinase phosphatase-1 mediates inhibition of lipopolysaccharide-induced cyclooxygenase-2 expression in RAW 264.7 cells.

  European journal of pharmacology 20060717

• Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells.

  Blood 20060715

• Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation.

  Biochemical and biophysical research communications 20060707

• Triptolide inhibits COX-2 expression via NF-kappa B pathway in astrocytes.

  Neuroscience research 20060601

• (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation.

  Journal of neuroimmunology 20060601

• Liquid chromatographic/mass spectrometry assay of triptolide in dog plasma and its application to pharmacokinetic study.

  Journal of pharmaceutical and biomedical analysis 20060503

• Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide.

  Journal of molecular medicine (Berlin, Germany) 20060501

• Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death.

  The Journal of biological chemistry 20060407

• Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities.

  Bioorganic & medicinal chemistry letters 20060401

• Inhibitory effects of Triptolide on interferon-gamma-induced human leucocyte antigen-DR, intercellular adhesion molecule-1, CD40 expression on retro-ocular fibroblasts derived from patients with Graves' ophthalmopathy.

  Clinical & experimental ophthalmology 20060401

• Triptolide inhibits B7-H1 expression on proinflammatory factor activated renal tubular epithelial cells by decreasing NF-kappaB transcription.

  Molecular immunology 20060301

• The effect of triptolide on CD4+ and CD8+ cells in Peyer's patch of SD rats with collagen induced arthritis.

  International immunopharmacology 20060201

• Triptolide attenuates oxidative stress, NF-kappaB activation and multiple cytokine gene expression in murine peritoneal macrophage.

  International journal of molecular medicine 20060101

• Triptolide sensitizes resistant cholangiocarcinoma cells to TRAIL-induced apoptosis.

  Anticancer research 20060101

• A novel method to convert triptolide into tripchlorolide in Tripterygium wilfordii.

  Phytochemical analysis : PCA 20060101

• Effect of triptolide on expression of receptor activator of nuclear factor-kappaB ligand in rat adjuvant induced arthritis.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20060101

• Relationship between single nucleotide polymorphism in TNF-alpha gene promoter region and inhibitory effects of triptolide on TNF-alpha production in peripheral blood mononuclear cells of healthy humans.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20060101

• Monitoring of the conversion from triptolide to tripchlorolide in Triptergium wilfordii by micellar electrokinetic caillary chromatography.

  Journal of chromatography. A 20051202

• Studies on calcium dependence reveal multiple modes of action for triptolide.

  Chemistry & biology 20051201

• Triptolide, a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing phosphatidylinositol 3-kinase activity in human tumor cells.

  Biochemical and biophysical research communications 20051104

• Protection effect of triptolide to liver injury in rats with severe acute pancreatitis.

  Hepatobiliary & pancreatic diseases international : HBPD INT 20051101

• [Inhibitory effect of triptolide on proliferation of PC12 cells].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20051101

• Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking.

  Blood 20051001

• Inhibition of the nuclear factor-kappaB signaling pathway by leflunomide or triptolide also inhibits the anthralin-induced inflammatory response but does not affect keratinocyte growth inhibition.

  Biological & pharmaceutical bulletin 20050901

• Triptolide affects the differentiation, maturation and function of human dendritic cells.

  International immunopharmacology 20050801

• [Effects of triptolide on anti-angiogenesis by reducing expression of urokinase plasminogen activator].

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20050801

• Inhibitory effect of triptolide on chemokine expression induced by proinflammatory cytokines in human corneal fibroblasts.

  Investigative ophthalmology & visual science 20050701

• [Effect of triptolide on expression of urokinase-type plasminogen activators in vascular endothelial cells].

  Ai zheng = Aizheng = Chinese journal of cancer 20050701

• [Study of triptolide-induced apoptosis in MUTZ-1 cells and its allied mechanism].

  Zhongguo shi yan xue ye xue za zhi 20050601

• Clinical observation on effect of triptolide tablet in treating patients with psoriasis vulgaris.

  Chinese journal of integrative medicine 20050601

• [The effects of triptolide inhibition of mouse lymphocytes activated in vitro].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050601

• [Effects of triptolide on migration of vascular endothelial cells].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20050501

• [Effect of triptolide on urinary monocyte chemottractant protein-1 in patients with diabetic nephropathy].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050501

• [Isopropyl myristate molecular gels and drug-loaded transdermal capability].

  Yao xue xue bao = Acta pharmaceutica Sinica 20050501

• Determination of triptolide in root extracts of Tripterygium wilfordii by solid-phase extraction and reverse-phase high-performance liquid chromatography.

  Journal of chromatography. A 20050408

• The research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticle.

  Pharmacological research 20050401

• Triptolide protects dopaminergic neurons from inflammation-mediated damage induced by lipopolysaccharide intranigral injection.

  Neurobiology of disease 20050401

• FK506 enhances triptolide-induced down-regulation of cyclooxygenase-2, inducible nitric oxide synthase as well as their products PGE2 and NO in TNF-alpha-stimulated synovial fibroblasts from rheumatoid arthritic patients.

  European journal of medical research 20050329

• Anti-inflammatory effects of triptolide loaded poly(D,L-lactic acid) nanoparticles on adjuvant-induced arthritis in rats.

  Journal of ethnopharmacology 20050227

• Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes.

  Biochemical and biophysical research communications 20050204

• Triptolide suppresses CD80 and CD86 expressions and IL-12 production in THP-1 cells.

  Acta pharmacologica Sinica 20050201

• [Progress in research on triptolide].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050201

• [Determination of triptolide in Tripterygium total terpenoids tablets by HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050201

• Stent-based delivery of triptolide reduces neointimal formation in rabbit iliac arteries.

  Chinese medical journal 20050120

• Determination of triptolide and triptonide in human plasma by high-performance liquid chromatography.

  Biomedical chromatography : BMC 20050101

• Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells.

  Leukemia research 20050101

• Triptolide loaded solid lipid nanoparticle hydrogel for topical application.

  Drug development and industrial pharmacy 20050101

• Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines.

  Immunopharmacology and immunotoxicology 20050101

• Effects of triptolide on the expression and activity of NF-kappaB in synovium of collagen-induced arthritis rats.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

• The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages.

  The Journal of biological chemistry 20041224

• [Influence of triptolide on neuronal apoptosis in rat with cerebral injury after focal ischemia reperfusion].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20041101

• Recent pharmacological studies on natural products in China.

  European journal of pharmacology 20041001

• [Progress in structure modification of triptolide].

  Yao xue xue bao = Acta pharmaceutica Sinica 20041001

• Triptolide, an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F, inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcription.

  Arthritis and rheumatism 20040901

• A study of microemulsion systems for transdermal delivery of triptolide.

  Journal of controlled release : official journal of the Controlled Release Society 20040827

• Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation.

  Biochemical and biophysical research communications 20040702

• Synergistic effect of triptolide and tacrolimus on rat cardiac allotransplantation.

  Japanese heart journal 20040701

• [Preparation and toxicity of triptolide-loaded poly (D,L-lactic acid) nanoparticles].

  Yao xue xue bao = Acta pharmaceutica Sinica 20040701

• Triptolide inhibits murine-inducible nitric oxide synthase expression by down-regulating lipopolysaccharide-induced activity of nuclear factor-kappa B and c-Jun NH2-terminal kinase.

  European journal of pharmacology 20040621

• Biotransformation of triptolide and triptonide by cell suspension cultures of Catharanthus roseus.

  Journal of Asian natural products research 20040601

• New drugs to improve transplant outcomes.

  Transplantation 20040515

• [Regulatory function of nuclear factor kappa B on lymphocyte proliferation and apoptosis in bronchial asthmatic rats and effect of triptolide on the regulation].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040501

• Longitudinal transcriptional analysis of developing neointimal vascular occlusion and pulmonary hypertension in rats.

  Physiological genomics 20040413

• TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation.

  American journal of physiology. Gastrointestinal and liver physiology 20040301

• Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation.

  Journal of neuroimmunology 20040301

• [Effect of Triptolide on TNFalpha-induced activation of NF-kappaB and expression of COX-2 and iNOS in human rheumatoid arthritis synovial fibroblasts].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20040301

• [Effect of Chinese herb Tripterygium wilfordii Hook F monomer triptolide on apoptosis of PC12 cells induced by Abeta1-42].

  Sheng li xue bao : [Acta physiologica Sinica] 20040225

• [Progress in biotransformation of triptolides and bufadienolides].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20040201

• Triptolide down-regulates bcr-abl expression and induces apoptosis in chronic myelogenous leukemia cells.

  Leukemia & lymphoma 20040201

• Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts.

  BMC pharmacology 20040101

• Inhibition by triptolide of IL-1-induced collagen degradation by corneal fibroblasts.

  Investigative ophthalmology & visual science 20031201

• The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response.

  International immunopharmacology 20031001

• Analysis of triptolide-regulated gene expression in Jurkat cells by complementary DNA microarray.

  Acta pharmacologica Sinica 20030901

• Solid lipid nanoparticle and microemulsion for topical delivery of triptolide.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20030901

• PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy.

  Molecular cancer therapeutics 20030901

• PG490-mediated sensitization of lung cancer cells to Apo2L/TRAIL-induced apoptosis requires activation of ERK2.

  Oncogene 20030821

• Immunosuppressant PG490 (triptolide) induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells.

  Biochemical pharmacology 20030715

• [Neuroprotective effects of Tripterygium Wilforddi Hook F monomer T10 on glutamate induced PC12 cell line damage and its mechanism].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20030618

• Triptolide inhibits TNF-alpha, IL-1 beta and NO production in primary microglial cultures.

  Neuroreport 20030523

• [Enhancement by FK506 of triptolide-induced inhibition of expression of COX-2 and iNOS in human rheumatoid arthritis synovial fibroblasts].

  Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 20030301

• Triptolide inhibits the growth and metastasis of solid tumors.

  Molecular cancer therapeutics 20030101

• Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f.

  Drugs in R&D 20030101

• Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappaB activation.

  Experimental & molecular medicine 20021231

• Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages.

  Journal of immunology (Baltimore, Md. : 1950) 20021201

• [Effects of chlorotriptolide and triptonide on chromosome aberration and micronuclei of bone marrow cell in male rats].

  Zhonghua nan ke xue = National journal of andrology 20021201

• Triptolide is a potent suppressant of C3, CD40 and B7h expression in activated human proximal tubular epithelial cells.

  Kidney international 20021001

• [Several monomes from Tripterygium wilfordii inhibit proliferation of glioma cells in vitro].

  Ai zheng = Aizheng = Chinese journal of cancer 20021001

• Triptolide inhibits proinflammatory factor-induced over-expression of class II MHC and B7 molecules in renal tubular epithelial cells.

  Acta pharmacologica Sinica 20020901

• Synergistic cytotoxicity and apoptosis induced in human cholangiocarcinoma cell lines by a combined treatment with tumor necrosis factor-alpha (TNF-alpha) and triptolide.

  Asian Pacific journal of allergy and immunology 20020901

• Liver fluke-associated cholangiocarcinoma.

  The British journal of surgery 20020801

• Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020801

• [The effect of triptolide on the proliferation of airway smooth muscle and the expression of c-fos and c-jun in asthmatic rats].

  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20020501

• Inhibition of vascular endothelial growth factor expression and production by triptolide.

  Planta medica 20020401

• Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells.

  Oncogene 20011129

• [Triptolide inhibits vascular endothelial growth factor expression and production by endothelial cells].

  Zhonghua yi xue za zhi 20010925

• Triptolide, a novel diterpenoid triepoxide from Tripterygium wilfordii Hook. f., suppresses the production and gene expression of pro-matrix metalloproteinases 1 and 3 and augments those of tissue inhibitors of metalloproteinases 1 and 2 in human synovial fibroblasts.

  Arthritis and rheumatism 20010901

• Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F.

  Leukemia & lymphoma 20010701

• Triptolide inhibits vascular endothelial growth factor expression and production in endothelial cells.

  Acta pharmacologica Sinica 20010701

• Triptolide induced cytotoxic effects on human promyelocytic leukemia, T cell lymphoma and human hepatocellular carcinoma cell lines.

  Toxicology letters 20010531

• PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis.

  The American journal of pathology 20010301

• Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway.

  The Journal of biological chemistry 20010119

• Chiral auxiliaries for asymmetric radical cyclization reactions: application to the enantioselective synthesis of (+)-triptocallol.

  Organic letters 20010111

• [Determination of triptolide in human plasma by gas chromatography-electron capture detection].

  Se pu = Chinese journal of chromatography 20010101

• [Effect of Tripterygium wilfordii on Th1, Th2 cytokines production in asthma patients].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010101

• [Effect of tripterygium polyglucoside on T-lymphocyte subsets and serum interleukin-5 level in asthma patients].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010101