39524-08-8 | Asperosaponin VI

Packsize	Purity	Availability	Price	Discounted Price
10mg	≥98%	in stock	$88.00	$62.00
50mg	≥98%	in stock	$389.00	$272.00
100mg	98% by HPLC	in stock	$663.00	$464.00
500mg	98% by HPLC	in stock	$2,012.00	$1,408.00
1000mg	98% by HPLC	in stock	$3,185.00	$2,230.00

Description

• Catalog Number: AF69221
• Chemical Name: Asperosaponin VI
• CAS Number: 39524-08-8
• Molecular Formula: C47H76O18
• Molecular Weight: 929.0955
• MDL Number: MFCD25371916
• SMILES: OC[C@H]1O[C@@H](OC[C@H]2O[C@@H](OC(=O)[C@]34CC[C@@]5(C(=CC[C@H]6[C@@]5(C)CC[C@@H]5[C@]6(C)CC[C@@H]([C@@]5(C)CO)O[C@@H]5OC[C@@H]([C@@H]([C@H]5O)O)O)[C@@H]4CC(CC3)(C)C)C)[C@@H]([C@H]([C@@H]2O)O)O)[C@@H]([C@H]([C@@H]1O)O)O

Computed Properties

• Complexity: 1770
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 23
• Heavy Atom Count: 65
• Hydrogen Bond Acceptor Count: 18
• Hydrogen Bond Donor Count: 11
• Rotatable Bond Count: 10
• XLogP3: 0.8

Literature

• Long-term oral Asperosaponin VI attenuates cardiac dysfunction, myocardial fibrosis in a rat model of chronic myocardial infarction.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501

• Akebia saponin D attenuates ibotenic acid-induced cognitive deficits and pro-apoptotic response in rats: involvement of MAPK signal pathway.

  Pharmacology, biochemistry, and behavior 20120501

• Determination of asperosaponin VI in dog plasma by high-performance liquid chromatography-tandem mass spectrometry and its application to a pilot pharmacokinetic study.

  Biomedical chromatography : BMC 20120101

• Simultaneous determination of asperosaponin VI and its active metabolite hederagenin in rat plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in pharmacokinetic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111115

• [Studies on optimizing preparation technics of wumeitougu oral liquid by response surface methodology].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110201

• Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways.

  European journal of pharmacology 20101215

• In vitro & in vivo assessment of a herbal formula used topically for bone fracture treatment.

  Journal of ethnopharmacology 20100915

• Determination of asperosaponin VI in rat plasma by HPLC-ESI-MS and its application to preliminary pharmacokinetic studies.

  Biomedical chromatography : BMC 20100501

• Protective roles of Asperosaponin VI, a triterpene saponin isolated from Dipsacus asper Wall on acute myocardial infarction in rats.

  European journal of pharmacology 20100210

• Akebia saponin D, a saponin component from Dipsacus asper Wall, protects PC 12 cells against amyloid-beta induced cytotoxicity.

  Cell biology international 20091001