401900-40-1 | (2S)-3-[4-(Acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%	in stock	$44.00	$31.00
25mg	98%	in stock	$110.00	$77.00
100mg	98%	in stock	$322.00	$225.00

Description

• Catalog Number: AF67961
• Chemical Name: (2S)-3-[4-(Acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
• CAS Number: 401900-40-1
• Molecular Formula: C19H18F3N3O6
• Molecular Weight: 441.3579295999999
• MDL Number: MFCD09027386
• SMILES: CC(=O)Nc1ccc(cc1)OC[C@@](C(=O)Nc1ccc(c(c1)C(F)(F)F)N(=O)=O)(O)C

Computed Properties

• Complexity: 663
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 31
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 6
• XLogP3: 2.2

Literature

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• SARM-S4 and metabolites detection in sports drug testing: a case report.

  Forensic science international 20111210

• Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator andarine (S-4) for routine doping control purposes.

  Rapid communications in mass spectrometry : RCM 20100815

• Effects of a novel selective androgen receptor modulator on dexamethasone-induced and hypogonadism-induced muscle atrophy.

  Endocrinology 20100801

• [Bone and Men's Health. Bone selective androgen receptor modulators].

  Clinical calcium 20100201

• Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.

  Journal of medicinal chemistry 20090625

• Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators.

  Bioorganic & medicinal chemistry letters 20081015

• Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats.

  Pharmaceutical research 20070201

• In vivo metabolism and final disposition of a novel nonsteroidal androgen in rats and dogs.

  Drug metabolism and disposition: the biological fate of chemicals 20061001

• Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats.

  Endocrinology 20051101

• A ligand-based approach to identify quantitative structure-activity relationships for the androgen receptor.

  Journal of medicinal chemistry 20040715

• Pharmacokinetics of S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro- 3-trifluoromethyl-phenyl)-propionamide in rats, a non-steroidal selective androgen receptor modulator.

  Xenobiotica; the fate of foreign compounds in biological systems 20040301