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Eukaryotic translation initiation factor 2 subunit α (eIF2α) inhibitor salubrinal attenuates paraquat-induced human lung epithelial-like A549 cell apoptosis by regulating the PERK-eIF2α signaling pathway.
Toxicology in vitro : an international journal published in association with BIBRA 20180201
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Endoplasmic reticulum stress restrains hepatocyte growth factor expression in hepatic stellate cells and rat acute liver failure model.
Chemico-biological interactions 20171101
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Endoplasmic Reticulum Stress Induction and ERK1/2 Activation Contribute to Nefazodone-Induced Toxicity in Hepatic Cells.
Toxicological sciences : an official journal of the Society of Toxicology 20161201
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Endoplasmic Reticulum Stress Plays a Key Role in Rotenone-Induced Apoptotic Death of Neurons.
Molecular neurobiology 20160101
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Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release.
Chemical research in toxicology 20150615
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Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling.
The FEBS journal 20150301
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Induction of fetal hemoglobin through enhanced translation efficiency of γ-globin mRNA.
Blood 20141023
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The PERK-eIF2α signaling pathway is involved in TCDD-induced ER stress in PC12 cells.
Neurotoxicology 20140901
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Arsenic trioxide induces unfolded protein response in vascular endothelial cells.
Archives of toxicology 20140201
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Calcineurin inhibitors recruit protein kinases JAK2 and JNK, TLR signaling and the UPR to activate NF-κB-mediated inflammatory responses in kidney tubular cells.
Toxicology and applied pharmacology 20131101
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Intervention in genotoxic stress-induced senescence by cordycepin through activation of eIF2α and suppression of Sp1.
Toxicological sciences : an official journal of the Society of Toxicology 20130801
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Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism.
Blood 20130725
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Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii.
Antimicrobial agents and chemotherapy 20130401
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Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction.
Free radical biology & medicine 20120901
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Endoplasmic reticulum stress mediates aristolochic acid I-induced apoptosis in human renal proximal tubular epithelial cells.
Toxicology in vitro : an international journal published in association with BIBRA 20120801
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Endoplasmic reticulum stress modulates nicotine-induced extracellular matrix degradation in human periodontal ligament cells.
Journal of periodontal research 20120601
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Sustained translational repression by eIF2α-P mediates prion neurodegeneration.
Nature 20120506
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Salubrinal, an endoplasmic reticulum stress blocker, modulates sleep homeostasis and activation of sleep- and wake-regulatory neurons.
Neuroscience 20120503
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Β-adrenergic receptor stimulation induces endoplasmic reticulum stress in adult cardiac myocytes: role in apoptosis.
Molecular and cellular biochemistry 20120501
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Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways.
Journal of cellular physiology 20120301
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Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning.
Autophagy 20120301
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A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.
Toxicology and applied pharmacology 20120115
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Effects of salubrinal on cadmium-induced apoptosis in HK-2 human renal proximal tubular cells.
Archives of toxicology 20120101
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Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease.
Progress in molecular biology and translational science 20120101
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Reactive oxygen species and p38 MAPK regulate Bax translocation and calcium redistribution in salubrinal-induced apoptosis of EBV-transformed B cells.
Cancer letters 20111227
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Endoplasmic reticulum stress causes EBV lytic replication.
Blood 20111117
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Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20110901
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Mechanism of pyrethroid pesticide-induced apoptosis: role of calpain and the ER stress pathway.
Toxicological sciences : an official journal of the Society of Toxicology 20110801
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Salubrinal, an eIF2α dephosphorylation inhibitor, enhances cisplatin-induced oxidative stress and nephrotoxicity in a mouse model.
Free radical biology & medicine 20110801
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Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema.
Journal of molecular medicine (Berlin, Germany) 20110601
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Subtilase cytotoxin activates MAP kinases through PERK and IRE1 branches of the unfolded protein response.
Toxicological sciences : an official journal of the Society of Toxicology 20110301
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ASK1 overexpression accelerates paraquat-induced autophagy via endoplasmic reticulum stress.
Toxicological sciences : an official journal of the Society of Toxicology 20110101
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Homocysteine-induced caspase-3 activation by endoplasmic reticulum stress in endothelial progenitor cells from patients with coronary heart disease and healthy donors.
Bioscience, biotechnology, and biochemistry 20110101
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Endoplasmic reticulum stress-mediated apoptosis of EBV-transformed B cells by cross-linking of CD70 is dependent upon generation of reactive oxygen species and activation of p38 MAPK and JNK pathway.
Journal of immunology (Baltimore, Md. : 1950) 20101215
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Homocysteine induces caspase activation by endoplasmic reticulum stress in platelets from type 2 diabetics and healthy donors.
Thrombosis and haemostasis 20100501
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The role of endoplasmic reticulum stress-related unfolded protein response in the radiocontrast medium-induced renal tubular cell injury.
Toxicological sciences : an official journal of the Society of Toxicology 20100401
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Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.
The Journal of clinical endocrinology and metabolism 20100301
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Endoplasmic reticulum stress plays critical role in brain damage after cerebral ischemia/reperfusion in rats.
Neurotoxicity research 20100201
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Phosphatase inhibitors with anti-angiogenic effect in vitro.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20100101
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Activation of PERK signaling attenuates Abeta-mediated ER stress.
PloS one 20100101
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Role of endoplasmic reticulum stress in alpha-TEA mediated TRAIL/DR5 death receptor dependent apoptosis.
PloS one 20100101
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Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction.
Biological & pharmaceutical bulletin 20100101
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Endoplasmic reticulum stress drives a regulatory phenotype in human T-cell clones.
Cellular immunology 20100101
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Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells.
Toxicology letters 20091215
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Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells.
Cancer chemotherapy and pharmacology 20091101
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Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol.
Journal of molecular neuroscience : MN 20090901
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Lopinavir co-induces insulin resistance and ER stress in human adipocytes.
Biochemical and biophysical research communications 20090814
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A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice.
Nature neuroscience 20090501
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Salubrinal, an inhibitor of protein synthesis, promotes deep slow wave sleep.
American journal of physiology. Regulatory, integrative and comparative physiology 20090101
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Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: a role for endothelial phenotypic changes and death.
American journal of physiology. Renal physiology 20090101
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Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors.
PloS one 20090101
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Cyclosporine-induced endoplasmic reticulum stress triggers tubular phenotypic changes and death.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20081101
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Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma.
The American journal of pathology 20081101
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ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells.
Virology 20080930
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Arsenite-induced cytotoxicity in dorsal root ganglion explants.
Free radical biology & medicine 20080415
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Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins.
Experimental cell research 20080310
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A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death.
Cell death and differentiation 20080301
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Eif-2a protects brainstem motoneurons in a murine model of sleep apnea.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20080227
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Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response.
Cell death and differentiation 20070801
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Mechanism of attenuation of angiotensin-II-induced protein degradation by insulin-like growth factor-I (IGF-I).
Cellular signalling 20070701
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Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells.
The Journal of pharmacology and experimental therapeutics 20070601
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eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory.
Cell 20070406
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Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.
The Journal of biological chemistry 20070209
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Calreticulin exposure dictates the immunogenicity of cancer cell death.
Nature medicine 20070101
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Protection of Bcl-2 by salubrinal.
Biochemical and biophysical research communications 20060811
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Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative.
Bioorganic & medicinal chemistry letters 20050901
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A new pharmacology--drugging stressed folding pathways.
Trends in molecular medicine 20050801
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A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
Science (New York, N.Y.) 20050211
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Endoplasmic reticulum (ER) stress in cumulus-oocyte complexes impairs pentraxin-3 secretion, mitochondrial membrane potential (DeltaPsi m), and embryo development.
Molecular endocrinology (Baltimore, Md.)