41034-52-0 | 1,2,3,4-Tetrahydro-isoquinoline-1-carboxylic acid

Packsize	Purity	Availability	Price	Discounted Price
100mg	96%	in stock	$10.00	$7.00
250mg	96%	in stock	$21.00	$15.00
1g	95%	in stock	$26.00	$19.00
2g	95%	in stock	$52.00	$37.00
5g	95%	in stock	$89.00	$63.00

Description

• Catalog Number: AF56206
• Chemical Name: 1,2,3,4-Tetrahydro-isoquinoline-1-carboxylic acid
• CAS Number: 41034-52-0
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.1998
• MDL Number: MFCD01318704
• SMILES: OC(=O)C1NCCc2c1cccc2

Computed Properties

• Complexity: 205
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• Undefined Atom Stereocenter Count: 1
• XLogP3: -1.2

Literature

• Variation of the intercalating proline in artificial peptides mimicking the DNA binding and bending IHF protein.

  Amino acids 20120701

• Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor γ selective agonists with protein-tyrosine phosphatase 1B inhibition.

  Bioorganic & medicinal chemistry 20120115

• 6-Phenyl-5a,6,6a,7,12,13a-hexa-hydro-5H-benzo[6,7]indolizino[3,2-a]pyrrolizine.

  Acta crystallographica. Section E, Structure reports online 20090701

• Therapeutic index of gramicidin S is strongly modulated by D-phenylalanine analogues at the beta-turn.

  Journal of medicinal chemistry 20090212

• Synthesis and biological evaluation of (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: a novel series of PPAR gamma agonists.

  Chemical & pharmaceutical bulletin 20080301

• Coordination compounds based on 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid.

  Molecules (Basel, Switzerland) 20070521

• Capillary electrophoresis for diastereomers of (R,S)-tetrahydroisoquinoline-3-carboxylic acid derivatized with (R)-4-nitro-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole: effect of molecular geometries.

  Journal of chromatographic science 20050301

• Modifications to the N-terminus but not the C-terminus of calcitonin gene-related peptide(8-37) produce antagonists with increased affinity.

  Journal of medicinal chemistry 20030605

• Tetrahydroisoquinoline-3-carboxylate based matrix-metalloproteinase inhibitors: design, synthesis and structure-activity relationship.

  Bioorganic & medicinal chemistry 20021101

• The structure of an endomorphin analogue incorporating 1-aminocyclohexane-1-carboxlylic acid for proline is similar to the beta-turn of Leu-enkephalin.

  Biochemical and biophysical research communications 20020913

• CCK(2) receptor antagonists containing the conformationally constrained phenylalanine derivatives, including the new amino acid Xic.

  European journal of medicinal chemistry 20020501

• Probing the shape of a hydrophobic pocket in the active site of delta-opioid antagonists.

  Journal of peptide science : an official publication of the European Peptide Society 20010701