41468-25-1 | Pyridoxal 5-phosphate monohydrate

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$12.00	$9.00
5g	97%	in stock	$15.00	$11.00
10g	97%	in stock	$18.00	$13.00
100g	97%	in stock	$114.00	$80.00
500g	97%	in stock	$418.00	$293.00

Description

• Catalog Number: AI50108
• Chemical Name: Pyridoxal 5-phosphate monohydrate
• CAS Number: 41468-25-1
• Molecular Formula: C8H11NO7P
• Molecular Weight: 264.1492
• MDL Number: MFCD00149414
• SMILES: O=Cc1c(COP(=O)(O)O)cnc(c1O)C.[OH]

Computed Properties

• Complexity: 292
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 4

Literature

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  Journal of the American Chemical Society 20150225

• Purinergic signaling via P2Y receptors up-mediates IL-6 production by liver macrophages/Kupffer cells.

  The Journal of toxicological sciences 20140601

• P2X7 receptors at adult neural progenitor cells of the mouse subventricular zone.

  Neuropharmacology 20131001

• Allosteric communication between the pyridoxal 5'-phosphate (PLP) and heme sites in the H2S generator human cystathionine β-synthase.

  The Journal of biological chemistry 20121102

• Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs.

  Disease models & mechanisms 20121101

• Exploration of the active site of Escherichia coli cystathionine γ-synthase.

  Protein science : a publication of the Protein Society 20121101

• Vitamin D improves the angiogenic properties of endothelial progenitor cells.

  American journal of physiology. Cell physiology 20121101

• Purinergic modulation of hypoxic regulation via the rostral ventral lateral medulla in rats.

  Respiratory physiology & neurobiology 20121015

• Metal ion dependency of serine racemase from Dictyostelium discoideum.

  Amino acids 20121001

• Structural insights into catalysis by βC-S lyase from Streptococcus anginosus.

  Proteins 20121001

• Higher plasma homocysteine is associated with lower vitamin B6 status in critically ill surgical patients.

  Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 20121001

• Structures of a γ-aminobutyrate (GABA) transaminase from the s-triazine-degrading organism Arthrobacter aurescens TC1 in complex with PLP and with its external aldimine PLP-GABA adduct.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20121001

• Structural analysis of the substrate recognition mechanism in O-phosphoserine sulfhydrylase from the hyperthermophilic archaeon Aeropyrum pernix K1.

  Journal of molecular biology 20120907

• C-H activation in pyridoxal-5'-phosphate Schiff bases: the role of the imine nitrogen. A combined experimental and computational study.

  The journal of physical chemistry. B 20120906

• Contrast-enhanced MR cholangiography: comparison of Gd-EOB-DTPA and Mn-DPDP in healthy volunteers.

  The British journal of radiology 20120901

• A stable isotope dilution LC-ESI-MS/MS method for the quantification of pyridoxal-5'-phosphate in whole blood.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120815

• Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine β-synthase.

  Biochemistry 20120814

• Robust production of gamma-amino butyric acid using recombinant Corynebacterium glutamicum expressing glutamate decarboxylase from Escherichia coli.

  Enzyme and microbial technology 20120810

• Decarboxylation mechanisms in biological system.

  Bioorganic chemistry 20120801

• Epilepsy as a pyridoxine-dependent condition: quantified urinary biomarkers for status evaluation and monitoring antiepileptic treatment.

  Medical hypotheses 20120801

• Characterization of an acid phosphatase responsible for hydrolysis of pyridoxal 5'-phosphate in tobacco plants.

  Plant physiology and biochemistry : PPB 20120801

• Metanx alleviates multiple manifestations of peripheral neuropathy and increases intraepidermal nerve fiber density in Zucker diabetic fatty rats.

  Diabetes 20120801

• Theoretical study on HF elimination and aromatization mechanisms: a case of pyridoxal 5' phosphate-dependent enzyme.

  The Journal of organic chemistry 20120706

• Role of conserved active site tryptophan-101 in functional activity and stability of phosphoserine aminotransferase from an enteric human parasite.

  Amino acids 20120701

• The platelet count in EDTA-anticoagulated blood from patients with thrombocytopenia may be underestimated when measured in routine laboratories.

  American journal of hematology 20120701

• Crystal structure and substrate specificity of the thermophilic serine:pyruvate aminotransferase from Sulfolobus solfataricus.

  Acta crystallographica. Section D, Biological crystallography 20120701

• Involvement of P2Y13 receptor in suppression of neuronal differentiation.

  Neuroscience letters 20120614

• Thiamin pyrimidine biosynthesis in Candida albicans : a remarkable reaction between histidine and pyridoxal phosphate.

  Journal of the American Chemical Society 20120606

• D-serine-dehydratase from Saccaromyces cerevisiae: a pyridoxal 5'- phosphate-dependent enzyme for advanced biotech applications.

  Protein and peptide letters 20120601

• Theoretical studies on the pyridoxal-5'-phosphate dependent enzyme dopa decarboxylase: effect of thr 246 residue on the co-factor-enzyme binding and reaction mechanism.

  Indian journal of biochemistry & biophysics 20120601

• Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjects.

  Nutrients 20120601

• Turning 'on' and 'off' a pyridoxal 5'-phosphate mimic using light.

  Angewandte Chemie (International ed. in English) 20120529

• Regulation of ventral surface CO2/H+-sensitive neurons by purinergic signalling.

  The Journal of physiology 20120501

• Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis.

  Acta crystallographica. Section D, Biological crystallography 20120501

• Use of differential scanning fluorimetry to optimize the purification and crystallization of PLP-dependent enzymes.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20120501

• Prediction of all-cause mortality by B group vitamin status in the elderly.

  Clinical nutrition (Edinburgh, Scotland) 20120401

• Postsynaptic mechanisms of CO(2) responses in parafacial respiratory neurons of newborn rats.

  The Journal of physiology 20120401

• P2X purinergic receptor knockout mice reveal endogenous ATP modulation of both vasopressin and oxytocin release from the intact neurohypophysis.

  Journal of neuroendocrinology 20120401

• Age-related changes in afferent responses in sensory neurons to mechanical stimulation of osteoblasts in coculture system.

  American journal of physiology. Cell physiology 20120301

• Crystal structure of D-serine dehydratase from Escherichia coli.

  Biochimica et biophysica acta 20120301

• Crystal structures of the Chromobacterium violaceumω-transaminase reveal major structural rearrangements upon binding of coenzyme PLP.

  The FEBS journal 20120301

• Formation of Schiff bases of O-phosphorylethanolamine and O-phospho-D,L-serine with pyridoxal 5'-phosphate. experimental and theoretical studies.

  The journal of physical chemistry. A 20120301

• Turning pyridoxal-5'-phosphate-dependent enzymes into thermostable binding proteins: D-Serine dehydratase from baker's yeast as a case study.

  Biochimie 20120201

• Role of histidine 225 in adenosylcobalamin-dependent ornithine 4,5-aminomutase.

  Bioorganic chemistry 20120201

• Synthesis of oxovanadium(IV) Schiff base complexes derived from C-substituted diamines and pyridoxal-5-phosphate as antitumor agents.

  Chemical biology & drug design 20120201

• A reassessment of P2X7 receptor inhibition as a neuroprotective strategy in rat models of contusion injury.

  Experimental neurology 20120201

• Structure and mechanism of a cysteine sulfinate desulfinase engineered on the aspartate aminotransferase scaffold.

  Biochimica et biophysica acta 20120201

• Type 1 diabetes impairs vitamin B(6) metabolism at an early stage of women's adulthood.

  Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 20120201

• Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions.

  The Journal of biological chemistry 20120127

• PPADS, a P2X receptor antagonist, as a novel inhibitor of the reverse mode of the Na⁺/Ca²⁺ exchanger in guinea pig airway smooth muscle.

  European journal of pharmacology 20120115

• Protein domain structure uncovers the origin of aerobic metabolism and the rise of planetary oxygen.

  Structure (London, England : 1993) 20120111

• Assembly of the eukaryotic PLP-synthase complex from Plasmodium and activation of the Pdx1 enzyme.

  Structure (London, England : 1993) 20120111

• Mutational analysis of Sep-tRNA:Cys-tRNA synthase reveals critical residues for tRNA-dependent cysteine formation.

  FEBS letters 20120102

• Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue.

  Journal of molecular neuroscience : MN 20120101

• Biochemical analyses are instrumental in identifying the impact of mutations on holo and/or apo-forms and on the region(s) of alanine:glyoxylate aminotransferase variants associated with primary hyperoxaluria type I.

  Molecular genetics and metabolism 20120101

• Pyridorin in type 2 diabetic nephropathy.

  Journal of the American Society of Nephrology : JASN 20120101

• Pyridoxal 5'-phosphate (PLP) deficiency might contribute to the onset of type I diabetes.

  Medical hypotheses 20120101

• Biomedical aspects of pyridoxal 5'-phosphate availability.

  Frontiers in bioscience (Elite edition) 20120101

• Plasma pyridoxal 5'-phosphate is not associated with inflammatory and immune responses after adjusting for serum albumin in patients with rheumatoid arthritis: a preliminary study.

  Annals of nutrition & metabolism 20120101

• The relationships between plasma and red cell vitamin B2 and B6 concentrations and the systemic and local inflammatory responses in patients with colorectal cancer.

  Nutrition and cancer 20120101

• Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population.

  PloS one 20120101

• Crystal structure of the cysteine desulfurase DndA from Streptomyces lividans which is involved in DNA phosphorothioation.

  PloS one 20120101

• Structural and mutational studies on substrate specificity and catalysis of Salmonella typhimurium D-cysteine desulfhydrase.

  PloS one 20120101

• Mechanisms of constitutive and ATP-evoked ATP release in neonatal mouse olfactory epithelium.

  BMC neuroscience 20120101

• Characteristic features of kynurenine aminotransferase allosterically regulated by (alpha)-ketoglutarate in cooperation with kynurenine.

  PloS one 20120101

• Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase.

  PloS one 20120101

• Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA.

  The Journal of biological chemistry 20111223

• Status epilepticus in a neonate treated with pyridoxine because of a familial recurrence risk for antiquitin deficiency: pyridoxine toxicity?

  Developmental medicine and child neurology 20111201

• Interconversions of different forms of vitamin B6 in tobacco plants.

  Phytochemistry 20111201

• Endo-inulinase stabilization by pyridoxal phosphate modification: a kinetics, thermodynamics, and simulation approach.

  Applied biochemistry and biotechnology 20111201

• Genomic distribution and heterogeneity of MocR-like transcriptional factors containing a domain belonging to the superfamily of the pyridoxal-5'-phosphate dependent enzymes of fold type I.

  Biochemical and biophysical research communications 20111111

• Stereospecificity of isotopic exchange of C-α-protons of glycine catalyzed by three PLP-dependent lyases: the unusual case of tyrosine phenol-lyase.

  Amino acids 20111101

• Pyridoxal-5'-phosphate-dependent enzymes involved in biotin biosynthesis: structure, reaction mechanism and inhibition.

  Biochimica et biophysica acta 20111101

• The PLP cofactor: lessons from studies on model reactions.

  Biochimica et biophysica acta 20111101

• PLP-dependent H(2)S biogenesis.

  Biochimica et biophysica acta 20111101

• (31)P NMR spectroscopy senses the microenvironment of the 5'-phosphate group of enzyme-bound pyridoxal 5'-phosphate.

  Biochimica et biophysica acta 20111101

• Pyridoxal-5'-phosphate as the catalyst for radical isomerization in reactions of PLP-dependent aminomutases.

  Biochimica et biophysica acta 20111101

• The enzymes of the transsulfuration pathways: active-site characterizations.

  Biochimica et biophysica acta 20111101

• The multifaceted pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase.

  Biochimica et biophysica acta 20111101

• Molecular dynamics simulations of the intramolecular proton transfer and carbanion stabilization in the pyridoxal 5'-phosphate dependent enzymes L-dopa decarboxylase and alanine racemase.

  Biochimica et biophysica acta 20111101

• Controlling reaction specificity in pyridoxal phosphate enzymes.

  Biochimica et biophysica acta 20111101

• Critical hydrogen bonds and protonation states of pyridoxal 5'-phosphate revealed by NMR.

  Biochimica et biophysica acta 20111101

• Pyridoxal phosphate-responsive seizures in a patient with cerebral folate deficiency (CFD) and congenital deafness with labyrinthine aplasia, microtia and microdontia (LAMM).

  Molecular genetics and metabolism 20111101

• Pyridoxal phosphate: biosynthesis and catabolism.

  Biochimica et biophysica acta 20111101

• Rapid determination of free D-serine with chicken D-serine dehydratase.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111101

• Haemolysis induced by α-toxin from Staphylococcus aureus requires P2X receptor activation.

  Pflugers Archiv : European journal of physiology 20111101

• Pyridoxal phosphate enzymology.

  Biochimica et biophysica acta 20111101

• Characterization of the PLP-dependent aminotransferase NikK from Streptomyces tendae and its putative role in nikkomycin biosynthesis.

  The FEBS journal 20111101

• PLP-dependent enzymes as potential drug targets for protozoan diseases.

  Biochimica et biophysica acta 20111101

• Characterization of enzymes involved in the interconversions of different forms of vitamin B(6) in tobacco leaves.

  Plant physiology and biochemistry : PPB 20111101

• Role for purinergic receptors in memory processing in young chicks.

  Behavioural brain research 20111001

• A novel mechanism of sulfur transfer catalyzed by O-acetylhomoserine sulfhydrylase in the methionine-biosynthetic pathway of Wolinella succinogenes.

  Acta crystallographica. Section D, Biological crystallography 20111001

• Chemoselective surface immobilization of proteins through a cleavable peptide.

  Bioconjugate chemistry 20110921

• Role of the pyridine nitrogen in pyridoxal 5'-phosphate catalysis: activity of three classes of PLP enzymes reconstituted with deazapyridoxal 5'-phosphate.

  Journal of the American Chemical Society 20110921

• Inhibitory effect of schisandrin on spontaneous contraction of isolated rat colon.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20110815

• Preoperative detection of colorectal liver metastases in fatty liver: MDCT or MRI?

  European journal of radiology 20110801

• Higher plasma pyridoxal 5'-phosphate is associated with better blood glucose responses in critically ill surgical patients with inadequate vitamin B-6 status.

  Clinical nutrition (Edinburgh, Scotland) 20110801

• A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition.

  European journal of cancer (Oxford, England : 1990) 20110801

• B-vitamin deficiency is protective against DSS-induced colitis in mice.

  American journal of physiology. Gastrointestinal and liver physiology 20110801

• Extracellular nucleotides and apyrases regulate stomatal aperture in Arabidopsis.

  Plant physiology 20110801

• Understanding non-enzymatic aminophospholipid glycation and its inhibition. Polar head features affect the kinetics of Schiff base formation.

  Bioorganic & medicinal chemistry 20110801

• A novel approach to inhibit intracellular vitamin B6-dependent enzymes: proof of principle with human and plasmodium ornithine decarboxylase and human histidine decarboxylase.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110701

• Acetylcholine and norepinephrine mediate GABAergic but not glycinergic transmission enhancement by melittin in adult rat substantia gelatinosa neurons.

  Journal of neurophysiology 20110701

• Exploring methionine γ-lyase structure-function relationship via microspectrophotometry and X-ray crystallography.

  Biochimica et biophysica acta 20110601

• Modulation of respiratory responses to chemoreflex activation by L-glutamate and ATP in the rostral ventrolateral medulla of awake rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20110601

• The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults.

  Psychosomatic medicine 20110601

• Cobalt cystathionine β-synthase: a cobalt-substituted heme protein with a unique thiolate ligation motif.

  Inorganic chemistry 20110516

• Biophysical characterization of Entamoeba histolytica phosphoserine aminotransferase (EhPSAT): role of cofactor and domains in stability and subunit assembly.

  European biophysics journal : EBJ 20110501

• Suppression of isotope scrambling in cell-free protein synthesis by broadband inhibition of PLP enymes for selective 15N-labelling and production of perdeuterated proteins in H2O.

  Journal of biomolecular NMR 20110501

• Multiphoton manipulations of enzymatic photoactivity in aspartate aminotransferase.

  The journal of physical chemistry. B 20110421

• Mechanism of Vibrio cholerae autoinducer-1 biosynthesis.

  ACS chemical biology 20110415

• A novel pyridoxal 5'-phosphate-dependent amino acid racemase in the Aplysia californica central nervous system.

  The Journal of biological chemistry 20110415

• Pyridoxal 5'-phosphate in cerebrospinal fluid; factors affecting concentration.

  Journal of inherited metabolic disease 20110401

• Pyridoxal 5' phosphate protects islets against streptozotocin-induced beta-cell dysfunction--in vitro and in vivo.

  Experimental biology and medicine (Maywood, N.J.) 20110401

• Mechanistic studies of 1-aminocyclopropane-1-carboxylate deaminase: characterization of an unusual pyridoxal 5'-phosphate-dependent reaction.

  Biochemistry 20110322

• Effect of ultrasound on the activity of alliinase from fresh garlic.

  Ultrasonics sonochemistry 20110301

• Insights into the structural properties of D-serine dehydratase from Saccharomyces cerevisiae: an FT-IR spectroscopic and in silico approach.

  Biochimie 20110301

• Involvement of the purinergic system in central cardiovascular modulation at the level of the nucleus ambiguus of anaesthetized rats.

  Experimental physiology 20110301

• Electroencephalographic and seizure manifestations of pyridoxal 5'-phosphate-dependent epilepsy.

  Epilepsy & behavior : E&B 20110301

• Vitamin B6 deficiency: a potential cause of refractory seizures in adults.

  JPEN. Journal of parenteral and enteral nutrition 20110301

• Imbuing aqueous solubility to amphotericin B and nystatin with a vitamin.

  Molecular pharmaceutics 20110207

• Purinergic mechanisms of lateral parabrachial nucleus facilitate sodium depletion-induced NaCl intake.

  Brain research 20110204

• Determination of cystathionine beta-synthase activity in human plasma by LC-MS/MS: potential use in diagnosis of CBS deficiency.

  Journal of inherited metabolic disease 20110201

• Necessary and sufficient conditions for the asymmetric synthesis of chiral amines using ω-aminotransferases.

  Biotechnology and bioengineering 20110201

• In airways ATP refills sarcoplasmic reticulum via P2X smooth muscle receptors and induces contraction through P2Y epithelial receptors.

  Pflugers Archiv : European journal of physiology 20110201

• P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells.

  American journal of physiology. Cell physiology 20110201

• Effect of P2 receptor blockade with pyridoxine on sympathetic response to exercise pressor reflex in humans.

  The Journal of physiology 20110201

• Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin).

  Therapeutic drug monitoring 20110201

• Mammalian retinal horizontal cells are unconventional GABAergic neurons.

  Journal of neurochemistry 20110201

• Maintained tubuloglomerular feedback responses during acute inhibition of P2 purinergic receptors in mice.

  American journal of physiology. Renal physiology 20110201

• Purinergic modulation of glucose uptake into cultured rat podocytes: effect of diabetic milieu.

  Biochemical and biophysical research communications 20110114

• Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages.

  Immunobiology 20110101

• The reliability of methionine challenge test is not affected by a deficiency in pyridoxal phosphate, folic acid, or cobalamin.

  Hypertension in pregnancy 20110101

• Positive transcriptional control of the pyridoxal phosphate biosynthesis genes pdxST by the MocR-type regulator PdxR of Corynebacterium glutamicum ATCC 13032.

  Microbiology (Reading, England) 20110101

• Propionate-induced epithelial K(+) and Cl(-)/HCO3(-) secretion and free fatty acid receptor 2 (FFA2, GPR43) expression in the guinea pig distal colon.

  Pflugers Archiv : European journal of physiology 20110101

• It takes two to tango: defining an essential second active site in pyridoxal 5'-phosphate synthase.

  PloS one 20110101

• The P2 receptor antagonist PPADS supports recovery from experimental stroke in vivo.

  PloS one 20110101

• Drosophila selenophosphate synthetase 1 regulates vitamin B6 metabolism: prediction and confirmation.

  BMC genomics 20110101

• Involvement of P2X receptors in the regulation of insulin secretion, proliferation and survival in mouse pancreatic β-cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

• Bacterial surface display of a co-factor containing enzyme, ω-transaminase from Vibrio fluvialis using the Bacillus subtilis spore display system.

  Bioscience, biotechnology, and biochemistry 20110101

• Mangafodipir protects against hepatic ischemia-reperfusion injury in mice.

  PloS one 20110101

• Rv2607 from Mycobacterium tuberculosis is a pyridoxine 5'-phosphate oxidase with unusual substrate specificity.

  PloS one 20110101

• Cardioprotective effect of a hemoglobin-based oxygen carrier on cold ischemia/reperfusion injury.

  Cardiology 20110101

• NMR studies of the stability, protonation States, and tautomerism of (13)C- AND (15)N-labeled aldimines of the coenzyme pyridoxal 5'-phosphate in water.

  Biochemistry 20101228

• Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1.

  The Biochemical journal 20101215

• Preliminary report: hyperhomocysteinemia in patients with acute intermittent porphyria.

  Metabolism: clinical and experimental 20101201

• Human liver peroxisomal alanine:glyoxylate aminotransferase: Different stability under chemical stress of the major allele, the minor allele, and its pathogenic G170R variant.

  Biochimie 20101201

• Purification, characterization and amino acid sequence of a novel enzyme, D-threo-3-hydroxyaspartate dehydratase, from Delftia sp. HT23.

  Journal of biochemistry 20101201

• A new function for ATP: activating cardiac sympathetic afferents during myocardial ischemia.

  American journal of physiology. Heart and circulatory physiology 20101201

• Astrocytes in the retrotrapezoid nucleus sense H+ by inhibition of a Kir4.1-Kir5.1-like current and may contribute to chemoreception by a purinergic mechanism.

  Journal of neurophysiology 20101201

• Light-enhanced catalysis by pyridoxal phosphate-dependent aspartate aminotransferase.

  Journal of the American Chemical Society 20101201

• Identification of highly reactive sequences for PLP-mediated bioconjugation using a combinatorial peptide library.

  Journal of the American Chemical Society 20101201

• Structures of bacterial biosynthetic arginine decarboxylases.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20101201

• A randomized, double-blind, crossover study on the pharmacokinetics of a novel formulation of CoQ₁₀ with pyridoxal 5'-phosphate and phosphatidyl choline.

  Journal of dietary supplements 20101201

• Multiple turnovers of the nicotino-enzyme PdxB require α-keto acids as cosubstrates.

  Biochemistry 20101102

• Dietary intake of vitamin B-6, plasma pyridoxal 5'-phosphate, and homocysteine in Puerto Rican adults.

  Journal of the American Dietetic Association 20101101

• Characterization of nestin expression in the spinal cord of GFP transgenic mice after peripheral nerve injury.

  Neuroscience 20101027

• Defining the structural requirements for ribose 5-phosphate-binding and intersubunit cross-talk of the malarial pyridoxal 5-phosphate synthase.

  FEBS letters 20101008

• Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis.

  Urology 20101001

• Differential effects of uridine adenosine tetraphosphate on purinoceptors in the rat isolated perfused kidney.

  British journal of pharmacology 20101001

• Kenji Soda--researching enzymes with the spirit of an alpinist.

  Journal of biochemistry 20101001

• Pharmacological properties and physiological function of a P2X-like current in single proximal tubule cells isolated from frog kidney.

  The Journal of membrane biology 20101001

• Magnetic resonance cholangiography with mangafodipir trisodium in Caroli's disease with pancreas involvement.

  JOP : Journal of the pancreas 20100906

• Cardiovascular effects of a novel synthetic analogue of naturally occurring piperamides.

  Journal of cardiovascular pharmacology 20100901

• Vitamin B(6) supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis.

  European journal of clinical nutrition 20100901

• Prevention of 7β-hydroxycholesterol-induced cell death by mangafodipir is mediated through lysosomal and mitochondrial pathways.

  European journal of pharmacology 20100825

• Structural analysis of WbpE from Pseudomonas aeruginosa PAO1: a nucleotide sugar aminotransferase involved in O-antigen assembly.

  Biochemistry 20100824

• Crystal structure-based selective targeting of the pyridoxal 5'-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement.

  Journal of medicinal chemistry 20100812

• Purinergic receptors in the rat lens: activation of P2X receptors following hyperosmotic stress.

  Investigative ophthalmology & visual science 20100801

• In vitro neurotoxicity of magnetic resonance imaging (MRI) contrast agents: influence of the molecular structure and paramagnetic ion.

  Toxicology in vitro : an international journal published in association with BIBRA 20100801

• Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency.

  Developmental medicine and child neurology 20100701

• Blocking P2X receptors can inhibit the injury-induced proliferation of olfactory epithelium progenitor cells in adult mouse.

  International journal of pediatric otorhinolaryngology 20100701

• Pyridoxal 5'-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic L-amino acid decarboxylase and vitamin B(6) deficiency states.

  Journal of neurochemistry 20100701

• Assessment and characterization of purinergic contractions and relaxations in the rat urinary bladder.

  Basic & clinical pharmacology & toxicology 20100701

• Insights into the mechanism of Pseudomonas dacunhae aspartate beta-decarboxylase from rapid-scanning stopped-flow kinetics.

  Biochemistry 20100622

• Vitamin B6 biosynthesis: charting the mechanistic landscape.

  Chembiochem : a European journal of chemical biology 20100614

• Vitamin B6, blood PLP level, and risk of colorectal cancer.

  JAMA 20100609

• K30, H150, and H168 are essential residues for coordinating pyridoxal 5'-phosphate of O-acetylserine sulfhydrylase from Acidithiobacillus ferrooxidans.

  Current microbiology 20100601

• Nickel sulfate induces location-dependent atrophy of mouse olfactory epithelium: protective and proliferative role of purinergic receptor activation.

  Toxicological sciences : an official journal of the Society of Toxicology 20100601

• NPY mediates ATP-induced neuroproliferation in adult mouse olfactory epithelium.

  Neurobiology of disease 20100601

• Mechanisms of protein kinase D activation in response to P2Y(2) and P2X7 receptors in primary astrocytes.

  Glia 20100601

• P2X(1) receptor blockade inhibits whole kidney autoregulation of renal blood flow in vivo.

  American journal of physiology. Renal physiology 20100601

• Intracellular Ca2+ responses and cell volume regulation upon cholinergic and purinergic stimulation in an immortalized salivary cell line.

  European journal of oral sciences 20100601

• An insight into the sequential, structural and phylogenetic properties of banana 1-aminocyclopropane-1-carboxylate synthase 1 and study of its interaction with pyridoxal-5'-phosphate and aminoethoxyvinylglycine.

  Journal of biosciences 20100601

• Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid.

  Acta paediatrica (Oslo, Norway : 1992) 20100501

• Activations of TRPA1 and P2X receptors are important in ROS-mediated stimulation of capsaicin-sensitive lung vagal afferents by cigarette smoke in rats.

  Journal of applied physiology (Bethesda, Md. : 1985) 20100501

• Purinergic contraction of the rat vas deferens in L-NAME-induced hypertension: effect of sildenafil.

  Asian journal of andrology 20100501

• Large conformational changes in the Escherichia coli tryptophan synthase beta(2) subunit upon pyridoxal 5'-phosphate binding.

  The FEBS journal 20100501

• Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase.

  The Journal of biological chemistry 20100430

• Purification and biochemical characterisation of a novel glutamate decarboxylase from rice bran.

  Journal of the science of food and agriculture 20100430

• The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding.

  The Journal of biological chemistry 20100423

• Functional interactions between nicotinic and P2X receptors in celiac ganglia neurons.

  Autonomic neuroscience : basic & clinical 20100419

• P2X7 receptors mediate ischemic damage to oligodendrocytes.

  Glia 20100415

• Chiral discrimination among aminotransferases: inactivation by 4-amino-4,5-dihydrothiophenecarboxylic acid.

  Biochemistry 20100413

• DFT studies on Schiff base formation of vitamin B6 analogues. Reaction between a pyridoxamine-analogue and carbonyl compounds.

  The journal of physical chemistry. A 20100408

• Ca(2+)-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X(7) receptor-mediated phosphoinositide 3-kinase signaling.

  Journal of neurochemistry 20100401

• Vitamin B6: Killing two birds with one stone?

  Phytochemistry 20100401

• Probing the effect of transport inhibitors on the conformation of the mitochondrial citrate transport protein via a site-directed spin labeling approach.

  Journal of bioenergetics and biomembranes 20100401

• Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding.

  Biochemical and biophysical research communications 20100326

• Gap junctions/hemichannels modulate interkinetic nuclear migration in the forebrain precursors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100324

• Endogenous purinergic control of bladder activity via presynaptic P2X3 and P2X2/3 receptors in the spinal cord.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100324

• Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies.

  JAMA 20100317

• Plasma homocysteine and cysteine and risk of breast cancer in women.

  Cancer research 20100315

• Differential purinergic signaling in bladder sensory neurons of naïve and bladder-inflamed mice.

  Pain 20100301

• L-cysteine stimulates hydrogen sulfide synthesis in myocardium associated with attenuation of ischemia-reperfusion injury.

  Journal of cardiovascular pharmacology and therapeutics 20100301

• Physiological role of alkaline phosphatase explored in hypophosphatasia.

  Annals of the New York Academy of Sciences 20100301

• Site-directed mutagenesis on human cystathionine-gamma-lyase reveals insights into the modulation of H2S production.

  Journal of molecular biology 20100226

• Peripheral origin of IL-1beta production in the rodent hippocampus under in vivo systemic bacterial lipopolysaccharide (LPS) challenge and its regulation by P2X(7) receptors.

  Journal of neuroimmunology 20100226

• Toward clinical application of manganese-enhanced MRI of retinal function.

  Brain research bulletin 20100215

• Chemoenzymatic synthesis of 1-deaza-pyridoxal 5'-phosphate.

  Bioorganic & medicinal chemistry letters 20100215

• Imitating prebiotic homochirality on Earth.

  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 20100201

• Two suramin binding sites are present in guinea pig but only one in murine native P2X myenteric receptors.

  European journal of pharmacology 20100125

• Internal proton transfer in the external pyridoxal 5'-phosphate Schiff base in dopa decarboxylase.

  Biochemistry 20100112

• Vitamin B6 metabolism in chronic kidney disease--relation to transsulfuration, advanced glycation and cardiovascular disease.

  Nephron. Clinical practice 20100101

• The P2 receptor antagonist PPADS abrogates LPS-induced neutrophil migration in the murine air pouch via inhibition of MIP-2 and KC production.

  Molecular immunology 20100101

• ATP release after partial hepatectomy regulates liver regeneration in the rat.

  Journal of hepatology 20100101

• P2Y receptors and atherosclerosis in apolipoprotein E-deficient mice.

  British journal of pharmacology 20100101

• Neonatal vitamin-responsive epileptic encephalopathies.

  Chang Gung medical journal 20100101

• Chronic and acute effects of walnuts on antioxidant capacity and nutritional status in humans: a randomized, cross-over pilot study.

  Nutrition journal 20100101

• Association of blood lead (Pb) and plasma homocysteine: a cross sectional survey in Karachi, Pakistan.

  PloS one 20100101

• Functional expression of muscarinic and purinoceptors in the urinary bladder of male and female rats and guinea pigs.

  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20100101

• Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5'-phosphate synthesis.

  Molecular systems biology 20100101

• Purinergic receptor functionality is necessary for infection of human hepatocytes by hepatitis delta virus and hepatitis B virus.

  PloS one 20100101

• Improvement of cutaneous sensitivity in diabetic peripheral neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate.

  Reviews in neurological diseases 20100101

• 5-HT2 receptors modulate excitatory neurotransmission to cardiac vagal neurons within the nucleus ambiguus evoked during and after hypoxia.

  Neuroscience 20091215

• Improved specific biodetection with ion trap mobility spectrometry (ITMS): a 10-min, multiplexed, immunomagnetic ELISA.

  Analytical chemistry 20091215

• Functional characterization of intracellular Dictyostelium discoideum P2X receptors.

  The Journal of biological chemistry 20091211

• ATP stimulates Ca(2+)-waves and gene expression in cultured human pulmonary fibroblasts.

  The international journal of biochemistry & cell biology 20091201

• Quantum mechanics/molecular mechanics (QM/MM) modeling of the irreversible transamination of L-kynurenine to kynurenic acid: the round dance of kynurenine aminotransferase II.

  Biochimica et biophysica acta 20091201

• Osmosensitive response of glutamate in the substantia nigra.

  Experimental neurology 20091201

• Structural determinants of GAD antigenicity.

  Molecular immunology 20091201

• The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA.

  Nature chemical biology 20091201

• Microglial phagocytosis attenuated by short-term exposure to exogenous ATP through P2X receptor action.

  Journal of neurochemistry 20091201

• Structural stability of the cofactor binding site in Escherichia coli serine hydroxymethyltransferase--the role of evolutionarily conserved hydrophobic contacts.

  The FEBS journal 20091201

• Molecular basis of reduced pyridoxine 5'-phosphate oxidase catalytic activity in neonatal epileptic encephalopathy disorder.

  The Journal of biological chemistry 20091106

• Substituent effects on the thermodynamic stability of imines formed from glycine and aromatic aldehydes: implications for the catalytic activity of pyridoxal-5'-phosphate.

  Journal of the American Chemical Society 20091104

• Secretin-stimulated multi-detector CT versus mangafodipir trisodium-enhanced MR imaging plus MRCP in characterization of non-metastatic solid pancreatic lesions.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20091101

• Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase.

  Molecular and biochemical parasitology 20091101

• Activation of purinergic receptors by ATP induces ventricular tachycardia by membrane depolarization and modifications of Ca2+ homeostasis.

  Journal of molecular and cellular cardiology 20091101

• Determination of pyridoxal-5'-phosphate (PLP)-bonding sites in proteins: a peptide mass fingerprinting approach based on diagnostic tandem mass spectral features of PLP-modified peptides.

  Rapid communications in mass spectrometry : RCM 20091101

• Miniature EPSCs in the lateral superior olive before hearing onset: regional and cell-type-specific differences and heterogeneous neuromodulatory effects of ATP.

  Brain research 20091027

• Dual roles of a conserved pair, Arg23 and Ser20, in recognition of multiple substrates in alpha-aminoadipate aminotransferase from Thermus thermophilus.

  Biochemical and biophysical research communications 20091009

• Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor.

  Journal of medicinal chemistry 20091008

• Pyridoxal 5'-phosphate: electrophilic catalyst extraordinaire.

  Current opinion in chemical biology 20091001

• Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis.

  Therapeutic drug monitoring 20091001

• Assay of alanine:glyoxylate aminotransferase in human liver by its serine: glyoxylate aminotransferase activity.

  Biomedical research (Tokyo, Japan) 20091001

• Serum folate is a reliable indicator of hyperhomocysteinemia and borderline hyperhomocysteinemia in young adults.

  Nutrition research (New York, N.Y.) 20091001

• [On the modified process of human hemoglobin based blood substitutes].

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20091001

• Hepatobiliary-specific MR contrast agents: role in imaging the liver and biliary tree.

  Radiographics : a review publication of the Radiological Society of North America, Inc 20091001

• Heme regulation of human cystathionine beta-synthase activity: insights from fluorescence and Raman spectroscopy.

  Journal of the American Chemical Society 20090909

• The effect of pyridoxal-5-phosphate on serum alanine aminotransferase activity in dogs suffering from canine babesiosis.

  The Onderstepoort journal of veterinary research 20090901

• Plasma vitamin B(6) and risk of myocardial infarction in women.

  Circulation 20090825

• Pyridoxal 5'-phosphate binding in lysine-modified PAMAM dendrimers: a biomimetic approach.

  Organic letters 20090820

• Multiple roles of the active site lysine of Dopa decarboxylase.

  Archives of biochemistry and biophysics 20090815

• Protein families reflect the metabolic diversity of organisms and provide support for functional prediction.

  Physiological genomics 20090807

• P2 receptor-mediated stimulation of the PI3-K/Akt-pathway in vivo.

  Glia 20090801

• Beta-N-methylaminoalanine (BMAA): metabolism and metabolic effects in model systems and in neural and other tissues of the rat in vitro.

  Toxicon : official journal of the International Society on Toxinology 20090801

• Induction of the histidine decarboxylase genes of Photobacterium damselae subsp. damselae (formally P. histaminum) at low pH.

  Journal of applied microbiology 20090801

• Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women.

  The American journal of clinical nutrition 20090801

• Vitamin B6 dependent seizures.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20090801

• P2X antagonists inhibit styryl dye entry into hair cells.

  Neuroscience 20090721

• (31)P NMR studies of O-acetylserine sulfhydrylase-B from Salmonella typhimurium.

  Archives of biochemistry and biophysics 20090715

• Utilization of an intron located polyadenlyation site resulted in four novel glutamate decarboxylase transcripts.

  Molecular biology reports 20090701

• A periplasmic, pyridoxal-5'-phosphate-dependent amino acid racemase in Pseudomonas taetrolens.

  Applied microbiology and biotechnology 20090701

• Tryptophan synthase: a mine for enzymologists.

  Cellular and molecular life sciences : CMLS 20090701

• Functional characterization of the first two actinomycete 4-amino-4-deoxychorismate lyase genes.

  Microbiology (Reading, England) 20090701

• Electrical stimulation of the mucosa evokes slow EPSPs mediated by NK1 tachykinin receptors and by P2Y1 purinoceptors in different myenteric neurons.

  American journal of physiology. Gastrointestinal and liver physiology 20090701

• Purinergic contribution to small intestinal afferent hypersensitivity in a murine model of postinfectious bowel disease.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20090601

• Stability of analytes related to clinical chemistry and bone metabolism in blood specimens after delayed processing.

  Clinical biochemistry 20090601

• Characterization of the S289A,D mutants of yeast cystathionine beta-synthase.

  Biochimica et biophysica acta 20090601

• Tumor models and specific contrast agents for small animal imaging in oncology.

  Methods (San Diego, Calif.) 20090601

• Molecular characterization of Mycobacterium tuberculosis cystathionine gamma synthase--apo- and holoforms.

  International journal of biological macromolecules 20090601

• Vitamins, not surgery: spinal fluid testing in hemispheric epilepsy.

  Pediatric neurology 20090601

• Involvement of P2Y receptors in pyridoxal-5'-phosphate-induced cardiac preconditioning.

  Fundamental & clinical pharmacology 20090601

• Modulation of firing activity by ATP in dopamine neurons of the rat substantia nigra pars compacta.

  Neuroscience 20090519

• Mechanism for multiple-substrates recognition of alpha-aminoadipate aminotransferase from Thermus thermophilus.

  Proteins 20090501

• Purinergic receptor activation evokes neurotrophic factor neuropeptide Y release from neonatal mouse olfactory epithelial slices.

  Journal of neuroscience research 20090501

• Gene cloning and expression of pyridoxal 5'-phosphate-dependent L-threo-3-hydroxyaspartate dehydratase from Pseudomonas sp. T62, and characterization of the recombinant enzyme.

  Journal of biochemistry 20090501

• A simplified protein precipitation and filtration procedure for determining serum vitamin B6 by high-performance liquid chromatography.

  Analytical biochemistry 20090501

• Influence of antivitamins ginkgotoxin 5'-phosphate and deoxypyridoxine 5'-phosphate on human pyridoxine 5'-phosphate oxidase.

  Planta medica 20090501

• Mechanically induced reactive gliosis causes ATP-mediated alterations in astrocyte stiffness.

  Journal of neurotrauma 20090501

• Characterization of the putative tryptophan synthase beta-subunit from Mycobacterium tuberculosis.

  Acta biochimica et biophysica Sinica 20090501

• The crystal structure of the Pseudomonas dacunhae aspartate-beta-decarboxylase dodecamer reveals an unknown oligomeric assembly for a pyridoxal-5'-phosphate-dependent enzyme.

  Journal of molecular biology 20090424

• ATP induces long-term potentiation of C-fiber-evoked field potentials in spinal dorsal horn: the roles of P2X4 receptors and p38 MAPK in microglia.

  Glia 20090415

• Structure, assembly, and mechanism of a PLP-dependent dodecameric L-aspartate beta-decarboxylase.

  Structure (London, England : 1993) 20090415

• Kinetic characterization of recombinant human cystathionine beta-synthase purified from E. coli.

  Protein expression and purification 20090401

• Homocysteine level and metabolism in ischemic stroke in the population of Northern Poland.

  Clinical biochemistry 20090401

• Molecular modeling and site-directed mutagenesis reveal essential residues for catalysis in a prokaryote-type aspartate aminotransferase.

  Plant physiology 20090401

• Extracellular ATP induces retinal photoreceptor apoptosis through activation of purinoceptors in rodents.

  The Journal of comparative neurology 20090401

• Interaction of hydrocortisone with ATP and adenosine on nerve-mediated contractions of frog skeletal muscle.

  European journal of pharmacology 20090401

• Purinergic neuron-to-glia signaling in the enteric nervous system.

  Gastroenterology 20090401

• Pre-steady state kinetics of ATP hydrolysis by Na,K-ATPase.

  Cell biochemistry and function 20090401

• Prospective study of plasma vitamin B6 and risk of colorectal cancer in men.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090401

• Purification, crystallization and preliminary X-ray analysis of NtdA, a putative pyridoxal phosphate-dependent aminotransferase from Bacillus subtilis.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20090401

• Roles of purines in synaptic modulation evoked by hypercapnia in isolated spinal cord of neonatal rat in vitro.

  British journal of pharmacology 20090401

• P2X7 nucleotide receptor is coupled to GSK-3 inhibition and neuroprotection in cerebellar granule neurons.

  Neurotoxicity research 20090401

• Regulation of adenosine 5'-triphosphate (ATP)-gated P2X(4) receptors on tracheal smooth muscle cells.

  Respiratory physiology & neurobiology 20090331

• Intersubunit cross-talk in pyridoxal 5'-phosphate synthase, coordinated by the C terminus of the synthase subunit.

  The Journal of biological chemistry 20090320

• Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy.

  Neuroscience letters 20090313

• A PLP-dependent polyketide chain releasing mechanism in the biosynthesis of mycotoxin fumonisins in Fusarium verticillioides.

  Journal of the American Chemical Society 20090311

• Dissection of contributions from invariant amino acids to complex formation and catalysis in the heteromeric pyridoxal 5-phosphate synthase complex from Bacillus subtilis.

  Biochemistry 20090310

• Spinal P2X receptor modulates muscle pressor reflex via glutamate.

  Journal of applied physiology (Bethesda, Md. : 1985) 20090301

• Characterization of endogenous pyridoxal 5'-phosphate-dependent alanine racemase from Bacillus pseudofirmus OF4.

  Journal of bioscience and bioengineering 20090301

• Light stimulation evokes two different calcium responses in Müller glial cells of the guinea pig retina.

  The European journal of neuroscience 20090301

• The novel structure of a pyridoxal 5'-phosphate-dependent fold-type I racemase, alpha-amino-epsilon-caprolactam racemase from Achromobacter obae.

  Biochemistry 20090210

• Taurine supplementation improves the utilization of sulfur-containing amino acids in rats continually administrated alcohol.

  The Journal of nutritional biochemistry 20090201

• An engineered folded PLP-bound monomer of Treponema denticola cystalysin reveals the effect of the dimeric structure on the catalytic properties of the enzyme.

  Proteins 20090201

• Coronary response to diadenosine pentaphosphate after ischaemia-reperfusion in the isolated rat heart.

  Cardiovascular research 20090201

• Polymerized placenta hemoglobin attenuates ischemia/reperfusion injury and restores the nitroso-redox balance in isolated rat heart.

  Free radical biology & medicine 20090201

• P2Y receptors mediate Ca2+ signaling in duodenocytes and contribute to duodenal mucosal bicarbonate secretion.

  American journal of physiology. Gastrointestinal and liver physiology 20090201

• New approaches for inhibiting HIV integrase: a journey beyond the active site.

  Current opinion in investigational drugs (London, England : 2000) 20090201

• Biochemical characterization of alanine racemase--a spore protein produced by Bacillus anthracis.

  BMB reports 20090131

• Morphine enhances microglial migration through modulation of P2X4 receptor signaling.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090128

• Mechanism of ATP-induced local and conducted vasomotor responses in isolated rat cerebral penetrating arterioles.

  Journal of vascular research 20090101

• The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase.

  The FEBS journal 20090101

• Detection of neuroendocrine liver metastases with MnDPDP-enhanced MRI.

  Neuroendocrinology 20090101

• Comparison of mechanical and electrical activity and interstitial cells of Cajal in urinary bladders from wild-type and W/Wv mice.

  British journal of pharmacology 20090101

• Mangafodipir as a cytoprotective adjunct to chemotherapy--a case report.

  Acta oncologica (Stockholm, Sweden) 20090101

• Poisoning pyridoxal 5-phosphate-dependent enzymes: a new strategy to target the malaria parasite Plasmodium falciparum.

  PloS one 20090101

• Antidipsogenic effects of central adenosine-5'-triphosphate.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20090101

• Purification and viral inactivation of hemoglobin from human placenta blood.

  Artificial cells, blood substitutes, and immobilization biotechnology 20090101

• [Imaging of the postoperative biliary tract].

  Journal de radiologie 20090101

• Pharmacokinetic comparison of a delayed-release combination of doxylamine succinate and pyridoxine hydrocholoride (Diclectin) and oral solutions of these drugs in healthy women of childbearing age.

  The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20090101

• Manganese-enhanced MRI of hypoxic-ischemic brain injuries using Mn-DPDP.

  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20090101

• Molecular and phylogenetic analysis of pyridoxal phosphate-dependent acyltransferase of Exiguobacterium acetylicum.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

• Spontaneous Ca2+ oscillations via purinergic receptors elicit transient cell swelling in rat parotid ducts.

  The journal of medical investigation : JMI 20090101

• Mechanism of substrate recognition and PLP-induced conformational changes in LL-diaminopimelate aminotransferase from Arabidopsis thaliana.

  Journal of molecular biology 20081231

• GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic receptors, modulating Ca2+ influx.

  Cell calcium 20081201

• The yeast mitochondrial citrate transport protein: identification of the Lysine residues responsible for inhibition mediated by Pyridoxal 5'-phosphate.

  Journal of bioenergetics and biomembranes 20081201

• Alteration of cholinergic, purinergic and sensory neurotransmission in the mouse colon of food allergy model.

  Neuroscience letters 20081121

• Nucleotide-induced Ca2+ signaling in sustentacular supporting cells of the olfactory epithelium.

  Glia 20081115

• Synthesis of beta-hydroxy-alpha-amino acids with a reengineered alanine racemase.

  Bioorganic & medicinal chemistry letters 20081115

• Cysteine synthase (CysM) of Mycobacterium tuberculosis is an O-phosphoserine sulfhydrylase: evidence for an alternative cysteine biosynthesis pathway in mycobacteria.

  The Journal of biological chemistry 20081114

• In vivo and in vitro examination of stability of primary hyperoxaluria-associated human alanine:glyoxylate aminotransferase.

  The Journal of biological chemistry 20081107

• ATP activates P2x receptors and requires extracellular Ca(++) participation to modify outer hair cell nonlinear capacitance.

  Pflugers Archiv : European journal of physiology 20081101

• Volume-activated chloride channels in mice Leydig cells.

  Pflugers Archiv : European journal of physiology 20081101

• Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects.

  British journal of pharmacology 20081101

• Homocysteine metabolism in the pre-ovulatory follicle during ovarian stimulation.

  Human reproduction (Oxford, England) 20081101

• PPADS does not block contraction-induced prostaglandin E2 synthesis in cat skeletal muscle.

  American journal of physiology. Heart and circulatory physiology 20081101

• Mangafodipir trisodium-enhanced MRI of hepatocellular carcinoma: correlation with histological characteristics.

  Clinical radiology 20081101

• A quantum mechanical/molecular mechanical study on the catalysis of the pyridoxal 5'-phosphate-dependent enzyme L-serine dehydratase.

  The journal of physical chemistry. B 20081016

• NO and CO binding profiles of hemoglobin vesicles as artificial oxygen carriers.

  Biochimica et biophysica acta 20081001

• Endogenous ATP potentiates only vasopressin secretion from neurohypophysial terminals.

  Journal of cellular physiology 20081001

• High-frequency fatigue of skeletal muscle: role of extracellular Ca(2+).

  European journal of applied physiology 20081001

• Purinergic type 2 receptors at GABAergic synapses on ventral tegmental area dopamine neurons are targets for ethanol action.

  The Journal of pharmacology and experimental therapeutics 20081001

• Analysis of a horizontally transferred pathway involved in vitamin B6 biosynthesis from the soybean cyst nematode Heterodera glycines.

  Molecular biology and evolution 20081001

• Dual effect of ATP on glucose-induced insulin secretion in HIT-T15 cells.

  Pancreas 20081001

• Industry-sponsored negative trials and the potential pitfalls of post hoc analysis.

  Archives of surgery (Chicago, Ill. : 1960) 20081001

• Age-related alterations of B-group vitamin contents in urine, blood and liver from rats.

  Journal of nutritional science and vitaminology 20081001

• [Study of polymerizing hemoglobin on cation exchange chromatography].

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20081001

• Inactive S298R disassembles the dodecameric L-aspartate 4-decarboxylase into dimers.

  Biochemical and biophysical research communications 20080912

• Optimization of a biomimetic transamination reaction.

  Journal of the American Chemical Society 20080903

• Clopidogrel treatment and the MEND-CABG II trial.

  JAMA 20080903

• Theoretical studies on pyridoxal 5'-phosphate-dependent transamination of alpha-amino acids.

  Journal of computational chemistry 20080901

• Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1.

  Journal of neurophysiology 20080901

• Importance of tyrosine residues of Bacillus stearothermophilus serine hydroxymethyltransferase in cofactor binding and L-allo-Thr cleavage.

  The FEBS journal 20080901

• Updated molecular knowledge about histamine biosynthesis by bacteria.

  Critical reviews in food science and nutrition 20080901

• Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations.

  Bioscience, biotechnology, and biochemistry 20080901

• Metabolism of the cysteine S-conjugate of busulfan involves a beta-lyase reaction.

  Drug metabolism and disposition: the biological fate of chemicals 20080801

• The purinergic antagonist PPADS reduces pain related behaviours and interleukin-1 beta, interleukin-6, iNOS and nNOS overproduction in central and peripheral nervous system after peripheral neuropathy in mice.

  Pain 20080701

• The use of 18F-FDG PET/CT in colorectal liver metastases--comparison with CT and liver MRI.

  European journal of nuclear medicine and molecular imaging 20080701

• 13C NMR snapshots of the complex reaction coordinate of pyridoxal phosphate synthase.

  Nature chemical biology 20080701

• Peering inside the black box to find enzyme-bound intermediates.

  Nature chemical biology 20080701

• D-amino acids in the brain: structure and function of pyridoxal phosphate-dependent amino acid racemases.

  The FEBS journal 20080701

• D-amino acids in the brain: pyridoxal phosphate-dependent amino acid racemases and the physiology of D-serine.

  The FEBS journal 20080701

• Pathway-dependent modulation by P2-purinoceptors in the mouse retina.

  The European journal of neuroscience 20080701

• The Legionella autoinducer synthase LqsA produces an alpha-hydroxyketone signaling molecule.

  The Journal of biological chemistry 20080627

• Structure and mutagenic conversion of E1 dehydrase: at the crossroads of dehydration, amino transfer, and epimerization.

  Biochemistry 20080617

• PLP catabolism: identification of the 2-(Acetamidomethylene)succinate hydrolase gene in Mesorhizobium loti MAFF303099.

  Biochemistry 20080610

• Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase.

  Biochemistry 20080610

• Therapeutic effects of the putative P2X3/P2X2/3 antagonist A-317491 on cyclophosphamide-induced cystitis in rats.

  Naunyn-Schmiedeberg's archives of pharmacology 20080601

• Pyridoxal 5'-phosphate values in cerebrospinal fluid: reference values and diagnosis of PNPO deficiency in paediatric patients.

  Molecular genetics and metabolism 20080601

• 2-Deoxy-D-ribose-induced oxidative stress causes apoptosis in human monocytic cells: prevention by pyridoxal-5'-phosphate.

  Toxicology in vitro : an international journal published in association with BIBRA 20080601

• Insights into the structural basis of substrate recognition by histidinol-phosphate aminotransferase from Corynebacterium glutamicum.

  Acta crystallographica. Section D, Biological crystallography 20080601

• Comparison of blood aminotransferase methods for assessment of myopathy and hepatopathy in Florida manatees (Trichechus manatus latirostris).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20080601

• Supplementing vitamin B6 to a low vitamin B6 diet exaggerates UVB-induced skin tumorigenesis in DMBA-treated hairless mice.

  Journal of nutritional science and vitaminology 20080601

• Vitamin B6 is associated with depressive symptomatology in Massachusetts elders.

  Journal of the American College of Nutrition 20080601

• Glutamatergic and purinergic mechanisms on respiratory modulation in the caudal NTS of awake rats.

  Respiratory physiology & neurobiology 20080531

• P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080521

• Rapid photodynamics of vitamin B6 coenzyme pyridoxal 5'-phosphate and its Schiff bases in solution.

  The journal of physical chemistry. B 20080508

• Purinergic P2X receptors presynaptically increase glutamatergic synaptic transmission in dorsolateral periaqueductal gray.

  Brain research 20080507

• Structure and mechanistic implications of a tryptophan synthase quinonoid intermediate.

  Chembiochem : a European journal of chemical biology 20080505

• Detection of colorectal hepatic metastases using MnDPDP MR imaging and diffusion-weighted imaging (DWI) alone and in combination.

  European radiology 20080501

• Sensitization of pelvic afferent nerves in the in vitro rat urinary bladder-pelvic nerve preparation by purinergic agonists and cyclophosphamide pretreatment.

  American journal of physiology. Renal physiology 20080501

• A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies.

  Biochimica et biophysica acta 20080501

• Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABA.

  Neuropharmacology 20080501

• Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.

  JAMA 20080416

• Role of Histidine-152 in cofactor orientation in the PLP-dependent O-acetylserine sulfhydrylase reaction.

  Archives of biochemistry and biophysics 20080415

• Effect of PPADS on achondroplasic chondrocytes: inhibition of FGF receptor type 3 over-activity.

  European journal of pharmacology 20080414

• Production of gamma-aminobutyric acid by Streptococcus salivarius subsp. thermophilus Y2 under submerged fermentation.

  Amino acids 20080401

• Isolation of a homocysteine gamma-lyase-producing bacterium and study of its enzyme production conditions.

  Journal of applied microbiology 20080401

• A positive inotropic effect of ATP in the human cardiac atrium.

  American journal of physiology. Heart and circulatory physiology 20080401

• Functional evidence for purinergic inhibitory neuromuscular transmission in the mouse internal anal sphincter.

  American journal of physiology. Gastrointestinal and liver physiology 20080401

• The signaling role of extracellular ATP and its dependence on Ca2+ flux in elicitation of Salvia miltiorrhiza hairy root cultures.

  Plant & cell physiology 20080401

• A randomized, double-blind, placebo-controlled, multicenter study to evaluate the cardioprotective effects of MC-1 in patients undergoing high-risk coronary artery bypass graft surgery: MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft Surgery Trial (MEND-CABG) II--study design and rationale.

  American heart journal 20080401

• Protective effect of pyridoxal-5-phosphate (MC-1) on perioperative myocardial infarction is independent of aortic cross clamp time: results from the MEND-CABG trial.

  The Journal of cardiovascular surgery 20080401

• Analysis of amadori-glycated phosphatidylethanolamine in the plasma of healthy subjects and diabetic patients by liquid chromatography-tandem mass spectrometry.

  Annals of the New York Academy of Sciences 20080401

• [Structure and function of amino acid racemases].

  Seikagaku. The Journal of Japanese Biochemical Society 20080401

• ATP facilitates glutamatergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus.

  Brain research 20080327

• Calcium- and salt-stress signaling in plants: shedding light on SOS pathway.

  Archives of biochemistry and biophysics 20080315

• PPADS, a purinergic antagonist reduces Fos expression at spinal cord level in a mouse model of mononeuropathy.

  Brain research 20080314

• Mechanistic studies on pyridoxal phosphate synthase: the reaction pathway leading to a chromophoric intermediate.

  Journal of the American Chemical Society 20080312

• Recruitment of excitatory serotonergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus post hypoxia and hypercapnia.

  Journal of neurophysiology 20080301

• Pyridoxal phosphate-dependent neonatal epileptic encephalopathy.

  Archives of disease in childhood. Fetal and neonatal edition 20080301

• Plasma pyridoxal 5'-phosphate and high-sensitivity C-reactive protein are independently associated with an increased risk of coronary artery disease.

  Nutrition (Burbank, Los Angeles County, Calif.) 20080301

• Elevated plasma homocysteine and low vitamin B-6 status in nonsupplementing older women with rheumatoid arthritis.

  Journal of the American Dietetic Association 20080301

• Involvement of purinergic P2 receptors in experimental retinal neovascularization.

  Current eye research 20080301

• Structure and catalytic mechanism of eukaryotic selenocysteine synthase.

  The Journal of biological chemistry 20080227

• A new fatal case of pyridox(am)ine 5'-phosphate oxidase (PNPO) deficiency.

  Molecular genetics and metabolism 20080201

• Negative and positive allosteric modulators of the P2X(7) receptor.

  British journal of pharmacology 20080201

• Connexins 37 and 40 transduce purinergic signals mediating renal autoregulation.

  American journal of physiology. Regulatory, integrative and comparative physiology 20080101

• Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension.

  American journal of physiology. Renal physiology 20080101

• Axon tracing in the adult rat optic nerve and tract after intravitreal injection of MnDPDP using a semiautomatic segmentation technique.

  Journal of magnetic resonance imaging : JMRI 20080101

• Trapping of a chromophoric intermediate in the Pdx1-catalyzed biosynthesis of pyridoxal 5'-phosphate.

  Angewandte Chemie (International ed. in English) 20080101

• Diadenosine polyphosphates are selective vasoconstrictors in human coronary artery bypass grafts.

  Vascular pharmacology 20080101

• Malate metabolism in Hoya carnosa mitochondria and its role in photosynthesis during CAM phase III.

  Journal of experimental botany 20080101

• Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme.

  BMC biochemistry 20080101

• Low plasma pyridoxal 5'-phosphate concentration and MTHFR 677C-->T genotypes are associated with increased risk of hypertension.

  International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20080101

• Pyridoxal plasma level in schizophrenic and schizoaffective patients with and without tardive dyskinesia.

  Clinical neuropharmacology 20080101

• Nonradioactive enzymatic assay for plasma and serum vitamin B(6).

  Nature protocols 20080101

• ATP released from beta-amyloid-stimulated microglia induces reactive oxygen species production in an autocrine fashion.

  Experimental & molecular medicine 20071231

• P2X1 and P2X4 receptor currents in mouse macrophages.

  British journal of pharmacology 20071201

• [Value of MRCP with Mangafodipir Trisodium (Teslascan) injection in the diagnosis and management of bile leaks].

  Journal de radiologie 20071201

• Mangafodipir-DPDP enhanced MRI visualization of a pancreatic adenocarcinoma previously undetected by extracellular contrast enhanced CT and MRI.

  Acta bio-medica : Atenei Parmensis 20071201

• Gene identification and structural characterization of the pyridoxal 5'-phosphate degradative protein 3-hydroxy-2-methylpyridine-4,5-dicarboxylate decarboxylase from mesorhizobium loti MAFF303099.

  Biochemistry 20071127

• Cloning and characterization of GDP-perosamine synthetase (Per) from Escherichia coli O157:H7 and synthesis of GDP-perosamine in vitro.

  Biochemical and biophysical research communications 20071123

• Downregulation of SGK1 by nucleotides in renal tubular epithelial cells.

  American journal of physiology. Renal physiology 20071101

• Differences in sympathetic neuroeffector transmission to rat mesenteric arteries and veins as probed by in vitro continuous amperometry and video imaging.

  The Journal of physiology 20071101

• Blockade of purinergic 2 receptors attenuates the mechanoreceptor component of the exercise pressor reflex.

  American journal of physiology. Heart and circulatory physiology 20071101

• Capillary electrophoretic screening for the inhibition of homocysteine thiolactone-induced protein oligomerization.

  Analytical chemistry 20071101

• DNA damage during glycation of lysine by methylglyoxal: assessment of vitamins in preventing damage.

  Amino acids 20071101

• In vivo resolution of conflicting in vitro results: synthesis of biotin from dethiobiotin does not require pyridoxal phosphate.

  Chemistry & biology 20071101

• Functional expression of ionotropic purinergic receptors on mouse taste bud cells.

  The Journal of physiology 20071015

• Ca2+-dependent ATP release from A549 cells involves synergistic autocrine stimulation by coreleased uridine nucleotides.

  The Journal of physiology 20071015

• Purinergic P2X receptor activation induces emetic responses in ferrets and Suncus murinus (house musk shrews).

  British journal of pharmacology 20071001

• High resolution structure and catalysis of O-acetylserine sulfhydrylase isozyme B from Escherichia coli.

  The FEBS journal 20071001

• Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals 'a tale of two mechanisms'.

  Biochemistry 20070918

• Manganese dipyridoxyl-diphosphate (MnDPDP) as a viability marker in patients with myocardial infarction.

  Journal of magnetic resonance imaging : JMRI 20070901

• A case of Pallister-Killian syndrome associated with West syndrome.

  Pediatric neurology 20070901

• Purinergic modulation of area postrema neuronal excitability in rat brain slices.

  Brain research 20070824

• Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia.

  Journal of molecular biology 20070817

• Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine.

  Biochemistry 20070807

• The effect of zinc on glycinergic inhibitory postsynaptic currents in rat spinal dorsal horn neurons.

  Brain research 20070803

• Pyridoxal phosphate prevents progression of diabetic nephropathy.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070801

• ATP-induced proliferation of developing retinal cells: regulation by factors released from postmitotic cells in culture.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20070801

• Mechanisms underlying mechanosensitivity of mesenteric afferent fibers to vascular flow.

  American journal of physiology. Gastrointestinal and liver physiology 20070801

• Re: diagnostic accuracy of portal-phase CT and MRI with mangafodipir trisodium in detecting liver metastases from colorectal carcinoma.

  Clinical radiology 20070801

• Treatable neonatal epilepsy.

  Archives of disease in childhood 20070801

• A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions.

  PLoS genetics 20070801

• Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes.

  Biochemistry 20070717

• A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane.

  The Biochemical journal 20070715

• Contrast enhanced cartilage imaging: Comparison of ionic and non-ionic contrast agents.

  European journal of radiology 20070701

• Purinergic P2X receptors mediate excitatory transmission to cardiac vagal neurons in the nucleus ambiguus after hypoxia.

  Hypertension (Dallas, Tex. : 1979) 20070701

• P2X3 receptor mediates heat hyperalgesia in a rat model of trigeminal neuropathic pain.

  The journal of pain : official journal of the American Pain Society 20070701

• Time course of changes in pyridoxal 5'-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage.

  Experimental neurology 20070701

• Purification and partial characterization of N-hydroxy-l-phenylalanine decarboxylase/oxidase from Bacillus sp. strain OxB-1, an enzyme involved in aldoxime biosynthesis in the 'aldoxime-nitrile pathway'.

  Biochimica et biophysica acta 20070701

• Ivermectin potentiates ATP-induced ion currents in cortical neurones: evidence for functional expression of P2X4 receptors?

  Neuroscience letters 20070627

• The mechanism of addition of pyridoxal 5'-phosphate to Escherichia coli apo-serine hydroxymethyltransferase.

  The Biochemical journal 20070615

• Involvement of L-glutamate and ATP in the neurotransmission of the sympathoexcitatory component of the chemoreflex in the commissural nucleus tractus solitarii of awake rats and in the working heart-brainstem preparation.

  The Journal of physiology 20070615

• P2 purinoceptor antagonists inhibit the non-adrenergic, non-cholinergic relaxation of the human colon in vitro.

  Neuroscience 20070615

• PPADS is a reversible competitive antagonist of the NAADP receptor.

  Cell calcium 20070601

• Pyridoxine-responsive seizures as the first symptom of infantile hypophosphatasia caused by two novel missense mutations (c.677T>C, p.M226T; c.1112C>T, p.T371I) of the tissue-nonspecific alkaline phosphatase gene.

  Bone 20070601

• Functional analysis of PDX2 from Arabidopsis, a glutaminase involved in vitamin B6 biosynthesis.

  Plant physiology 20070601

• Translational research: is there a future?

  The Journal of thoracic and cardiovascular surgery 20070601

• Effects of pyridoxal-5'-phosphate (MC-1) in patients undergoing high-risk coronary artery bypass surgery: results of the MEND-CABG randomized study.

  The Journal of thoracic and cardiovascular surgery 20070601

• Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase.

  Natural product reports 20070601

• Role of P2X and P2Y receptors in rat myocardial contractility during ontogeny.

  Bulletin of experimental biology and medicine 20070601

• P19 embryonal carcinoma cells as in vitro model for studying purinergic receptor expression and modulation of N-methyl-D-aspartate-glutamate and acetylcholine receptors during neuronal differentiation.

  Neuroscience 20070525

• Histidine 282 in 5-aminolevulinate synthase affects substrate binding and catalysis.

  Biochemistry 20070522

• NMR studies of coupled low- and high-barrier hydrogen bonds in pyridoxal-5'-phosphate model systems in polar solution.

  Journal of the American Chemical Society 20070516

• Cofactor-directed reversible denaturation pathways: the cofactor-stabilized Escherichia coli aspartate aminotransferase homodimer unfolds through a pathway that differs from that of the apoenzyme.

  Biochemistry 20070515

• Substantia nigra osmoregulation: taurine and ATP involvement.

  American journal of physiology. Cell physiology 20070501

• Evidence that ATP or a related purine is an excitatory neurotransmitter in the longitudinal muscle of mouse distal colon.

  British journal of pharmacology 20070501

• Thermodynamic characterization of the protein-protein interaction in the heteromeric Bacillus subtilis pyridoxalphosphate synthase.

  Biochemistry 20070501

• Molecular architecture of DesV from Streptomyces venezuelae: a PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine.

  Protein science : a publication of the Protein Society 20070501

• Regioselective labeling of antibodies through N-terminal transamination.

  ACS chemical biology 20070424

• 15N nuclear magnetic resonance studies of acid-base properties of pyridoxal-5'-phosphate aldimines in aqueous solution.

  The journal of physical chemistry. B 20070419

• Coupling of functional hydrogen bonds in pyridoxal-5'-phosphate-enzyme model systems observed by solid-state NMR spectroscopy.

  Journal of the American Chemical Society 20070411

• Purinergic control of the quail rectum: modulation of adenosine 5'-triphosphate-mediated contraction with acetylcholine.

  Research in veterinary science 20070401

• Maternal plasma pyridoxal-5'-phosphate concentrations and risk of isolated oral clefts in the Philippines.

  Birth defects research. Part A, Clinical and molecular teratology 20070401

• [New possibilities to study biliary tree and gallbladder: functional magnetic resonance cholangiography contrast-enhanced with mangafodipir trisodium (Mn DPDP)].

  Journal de radiologie 20070401

• New insights into the reaction mechanism catalyzed by the glutamate racemase enzyme: pH titration curves and classical molecular dynamics simulations.

  The journal of physical chemistry. B 20070308

• The apicomplexan parasite Toxoplasma gondii generates pyridoxal phosphate de novo.

  Molecular and biochemical parasitology 20070301

• Existence of high and low affinity dinucleotides pentaphosphate-induced calcium responses in individual synaptic terminals and lack of correlation with the distribution of P2X1-7 subunits.

  Neurochemistry international 20070301

• Nerve growth factor-stimulated neuronal differentiation induces changes in P2 receptor expression and nucleotide-stimulated catecholamine release.

  Journal of neurochemistry 20070301

• Evidence for the expression of multiple uracil nucleotide-stimulated P2 receptors coupled to smooth muscle contraction in porcine isolated arteries.

  British journal of pharmacology 20070301

• Purinergic modulation of respiration via medullary raphe nuclei in rats.

  Respiratory physiology & neurobiology 20070215

• P2X purinergic receptor-mediated ionic current in cardiac myocytes of calsequestrin model of cardiomyopathy: implications for the treatment of heart failure.

  American journal of physiology. Heart and circulatory physiology 20070201

• A novel mechanism of vasoregulation: ADP-induced relaxation of the porcine isolated coronary artery is mediated via adenosine release.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070201

• Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy.

  Journal of inherited metabolic disease 20070201

• Diagnostic accuracy of rim and segmental MRI enhancement of colorectal hepatic metastasis after administration of mangafodipir trisodium.

  AJR. American journal of roentgenology 20070201

• The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba.

  The FEBS journal 20070201

• Pyridoxal phosphate dependency, a newly recognized treatable catastrophic epileptic encephalopathy.

  Journal of inherited metabolic disease 20070201

• Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070124

• ATP increases intracellular calcium in supraoptic neurons by activation of both P2X and P2Y purinergic receptors.

  American journal of physiology. Regulatory, integrative and comparative physiology 20070101

• Purinergic 2 receptor blockade prevents the responses of group IV afferents to post-contraction circulatory occlusion.

  The Journal of physiology 20070101

• Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis.

  Neurobiology of disease 20070101

• Biochemical and molecular characterization of 18 patients with pyridoxine-dependent epilepsy and mutations of the antiquitin (ALDH7A1) gene.

  Human mutation 20070101

• Contractile activity of ATP and diadenosine tetraphosphate on urinary bladder in the rat: role of A1- and P2X-purinoceptors and nitric oxide.

  Autonomic & autacoid pharmacology 20070101

• Effects of ATP on rat renal haemodynamics and excretion: role of sodium intake, nitric oxide and cytochrome P450.

  Acta physiologica (Oxford, England) 20070101

• Pigment-epithelium-derived factor suppresses expression of receptor for advanced glycation end products in the eye of diabetic rats.

  Ophthalmic research 20070101

• Seminal plasma cobalamin significantly correlates with sperm concentration in men undergoing IVF or ICSI procedures.

  Journal of andrology 20070101

• Activation-dependent trafficking of NTPDase2 in Chinese hamster ovary cells.

  The international journal of biochemistry & cell biology 20070101

• Enzyme-catalyzed side reactions with molecular oxygen may contribute to cell signaling and neurodegenerative diseases.

  Neurochemical research 20070101

• Alanine racemase from the green alga Chlamydomonas reinhardtii.

  Amino acids 20070101

• Enhancing activity and controlling stereoselectivity in a designed PLP-dependent aldolase.

  Angewandte Chemie (International ed. in English) 20070101

• Pyridoxal 5'-phosphate enzymes as targets for therapeutic agents.

  Current medicinal chemistry 20070101

• Biochemical assessments of retinol, alpha-tocopherol, pyridoxal--5-phosphate oxidative stress index and total antioxidant status in adolescent professional basketball players and sedentary controls.

  International journal of adolescent medicine and health 20070101

• Novel inhibitors of glycation and AGE formation.

  Cell biochemistry and biophysics 20070101

• Vitamin B6 related epilepsy during childhood.

  Chang Gung medical journal 20070101

• Prevention of liver fibrosis by the purinoceptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS).

  In vivo (Athens, Greece) 20070101

• Purinergic nerves mediate the non-nitrergic relaxation of the human ileum in response to electrical field stimulation.

  Brain research bulletin 20061211

• Term-dependency of P2 receptor-mediated contractile responses of isolated human pregnant uterus.

  European journal of obstetrics, gynecology, and reproductive biology 20061201

• Consequences of missense mutations for dimerization and turnover of alanine:glyoxylate aminotransferase: study of a spectrum of mutations.

  Molecular genetics and metabolism 20061201

• Crystal structures of Aedes aegypti alanine glyoxylate aminotransferase.

  The Journal of biological chemistry 20061201

• Improved outcomes in islet isolation and transplantation by the use of a novel hemoglobin-based O2 carrier.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20061201

• Short communication: empirical and mechanistic evidence for the role of pyridoxal-5'-phosphate in the generation of methanethiol from methionine.

  Journal of dairy science 20061201

• Dimerization and folding processes of Treponema denticola cystalysin: the role of pyridoxal 5'-phosphate.

  Biochemistry 20061128

• The co-treatments of vigabatrin and P2X receptor antagonists protect ischemic neuronal cell death in the gerbil hippocampus.

  Brain research 20061120

• Nucleotide regulation of the voltage-dependent nonselective cation conductance in murine colonic myocytes.

  American journal of physiology. Cell physiology 20061101

• Exocytotic release of ATP and activation of P2X receptors in dissociated guinea pig stellate neurons.

  American journal of physiology. Cell physiology 20061101

• Involvement of peripheral purinoceptors in sympathetic modulation of capsaicin-induced sensitization of primary afferent fibers.

  Journal of neurophysiology 20061101

• Frequency and pattern dependence of adrenergic and purinergic vasoconstriction in rat skeletal muscle arteries.

  Experimental physiology 20061101

• An apparent unidirectional influx constant for manganese as a measure of myocardial calcium channel activity.

  Journal of magnetic resonance imaging : JMRI 20061101

• Enzymatic activation of sulfur for incorporation into biomolecules in prokaryotes.

  FEMS microbiology reviews 20061101

• Uracil nucleotides stimulate human neural precursor cell proliferation and dopaminergic differentiation: involvement of MEK/ERK signalling.

  Journal of neurochemistry 20061101

• Mechanism of the condensation of homocysteine thiolactone with aldehydes.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20061025

• Stereoselectivity and expanded substrate scope of an engineered PLP-dependent aldolase.

  Angewandte Chemie (International ed. in English) 20061020

• Manganese suppresses ATP-dependent intercellular calcium waves in astrocyte networks through alteration of mitochondrial and endoplasmic reticulum calcium dynamics.

  Brain research 20061003

• Vitamin B6 supplementation increases immune responses in critically ill patients.

  European journal of clinical nutrition 20061001

• Comparison of protein active site structures for functional annotation of proteins and drug design.

  Proteins 20061001

• Early effect of sodium valproate and carbamazepine monotherapy on homocysteine metabolism in children with epilepsy.

  Epilepsy research 20061001

• Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis.

  Proteins 20061001

• Detection of hepatic metastasis: manganese- and ferucarbotran-enhanced MR imaging.

  European journal of radiology 20061001

• Ginkgo nut intoxication in a 2-year-old male.

  Pediatric neurology 20061001

• Enhanced food intake after stimulation of hypothalamic P2Y1 receptors in rats: modulation of feeding behaviour by extracellular nucleotides.

  The European journal of neuroscience 20061001

• A plausible prebiotic synthesis of pyridoxal phosphate: vitamin B6 - a computational study.

  Biophysical chemistry 20060920

• Effect of pyridoxylidene aminoguanidine on human diploid cells B-HEF-2: in vitro cytotoxicity test and cytogenetic analysis.

  Toxicology in vitro : an international journal published in association with BIBRA 20060901

• Role of purinergic cotransmission in the sympathetic control of arterial pressure variability in conscious rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20060901

• Hypotonic stress activates BK channels in clonal kidney cells via purinergic receptors, presumably of the P2Y subtype.

  Acta physiologica (Oxford, England) 20060901

• Characterization of focal liver lesions: use of mangafodipir trisodium (MnDPDP)-enhanced MR images.

  The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 20060901

• P2Y receptor-mediated excitation in the posterior hypothalamus.

  The European journal of neuroscience 20060901

• Effects of bifemelane on the calcium level and ATP release of the human origin astrocyte clonal cell.

  Journal of pharmacological sciences 20060901

• Structural basis for D-amino acid transamination by the pyridoxal 5'-phosphate-dependent catalytic antibody 15A9.

  The Journal of biological chemistry 20060818

• Activation of Src/kinase/phospholipase C/mitogen-activated protein kinase and induction of neurite expression by ATP, independent of nerve growth factor.

  Neuroscience 20060811

• Activation and sensitization of C and Adelta afferent fibers mediated by P2X receptors in rat dorsal skin.

  Brain research 20060802

• Mediator mechanisms involved in TRPV1 and P2X receptor-mediated, ROS-evoked bradypneic reflex in anesthetized rats.

  Journal of applied physiology (Bethesda, Md. : 1985) 20060801

• Pyridoxal phosphate inhibits pituitary cell proliferation and hormone secretion.

  Endocrinology 20060801

• Diadenosine polyphosphate analog controls postsynaptic excitation in CA3-CA1 synapses via a nitric oxide-dependent mechanism.

  The Journal of pharmacology and experimental therapeutics 20060801

• Purinergic P2 receptors modulate excitability but do not mediate pH sensitivity of RTN respiratory chemoreceptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060705

• Local regulation of skin blood flow during cooling involving presynaptic P2 purinoceptors in rats.

  British journal of pharmacology 20060701

• P(2) purinoceptors account for the non-nitrergic NANC relaxation in the rat ileum.

  Naunyn-Schmiedeberg's archives of pharmacology 20060701

• Acetyl CoA carboxylase shares control of fatty acid synthesis with fatty acid synthase in bovine mammary homogenate.

  Journal of dairy science 20060701

• Histamine, histidine, and growth-phase mediated regulation of the histidine decarboxylase gene in lactic acid bacteria isolated from wine.

  FEMS microbiology letters 20060701

• Major classes of sensory neurons to the urinary bladder.

  Autonomic neuroscience : basic & clinical 20060630

• Transition state stabilization and alpha-amino carbon acidity in alanine racemase.

  Journal of the American Chemical Society 20060628

• [Hypophosphatasia].

  Nihon rinsho. Japanese journal of clinical medicine 20060628

• Structures of apo- and holo-tyrosine phenol-lyase reveal a catalytically critical closed conformation and suggest a mechanism for activation by K+ ions.

  Biochemistry 20060620

• Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of postsynaptic P2X receptors.

  The Journal of physiology 20060615

• A multifactorial design for studying factors influencing growth and tyramine production of the lactic acid bacteria Lactobacillus brevis CECT 4669 and Enterococcus faecium BIFI-58.

  Research in microbiology 20060601

• Effect of pH on the structure and stability of Bacillus circulans ssp. alkalophilus phosphoserine aminotransferase: thermodynamic and crystallographic studies.

  Proteins 20060601

• Cross-inhibitory interactions between GABAA and P2X channels in myenteric neurones.

  The European journal of neuroscience 20060601

• GABA-induced calcium signaling in cultured enteric neurons is reinforced by activation of cholinergic pathways.

  Neuroscience 20060512

• Imaging liver metastases: review and update.

  European journal of radiology 20060501

• ATPgammaS enhances the production of inflammatory mediators by a human dermal endothelial cell line via purinergic receptor signaling.

  The Journal of investigative dermatology 20060501

• Mangafodipir trisodium-enhanced MR imaging of pancreatic disease.

  European radiology 20060501

• Aminophospholipid glycation and its inhibitor screening system: a new role of pyridoxal 5'-phosphate as the inhibitor.

  Journal of lipid research 20060501

• Expression of recombinant goldfish glutamic acid decarboxylase 65 and evidence for differential pH and PLP responsiveness compared to the human enzyme.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20060501

• Mangafodipir trisodium-enhanced MRI for the detection and characterization of focal hepatic lesions: is delayed imaging useful?

  Journal of magnetic resonance imaging : JMRI 20060501

• Contrasting behaviors of mutant cystathionine beta-synthase enzymes associated with pyridoxine response.

  Human mutation 20060501

• Multiple motor effects of ATP and their inhibition by P purinoceptor antagonist, pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid in the small intestine of the guinea-pig.

  Basic & clinical pharmacology & toxicology 20060501

• Neuroprotective effects of the P2 receptor antagonist PPADS on focal cerebral ischaemia-induced injury in rats.

  The European journal of neuroscience 20060501

• P2X receptors in mouse Leydig cells.

  American journal of physiology. Cell physiology 20060401

• Molecular and biochemical characterization of a serine racemase from Arabidopsis thaliana.

  Phytochemistry 20060401

• Diagnostic accuracy of portal-phase CT and MRI with mangafodipir trisodium in detecting liver metastases from colorectal carcinoma.

  Clinical radiology 20060401

• New structural insights to help in the search for selective inhibitors of mammalian pyridoxal 5'-phosphate-dependent histidine decarboxylase . 4. Synthesis, metabolism and release of histamine.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060401

• Comparison of mangafodipir trisodium- and ferucarbotran-enhanced MRI for detection and characterization of hepatic metastases in colorectal cancer patients.

  AJR. American journal of roentgenology 20060401

• The purinergic component of human vas deferens contraction.

  Fertility and sterility 20060401

• Spectral and kinetic characterization of 7,8-diaminopelargonic acid synthase from Mycobacterium tuberculosis.

  IUBMB life 20060401

• Structural and functional characterization of PseC, an aminotransferase involved in the biosynthesis of pseudaminic acid, an essential flagellar modification in Helicobacter pylori.

  The Journal of biological chemistry 20060331

• Decavanadate, a P2X receptor antagonist, and its use to study ligand interactions with P2X7 receptors.

  European journal of pharmacology 20060318

• L-cysteate sulpho-lyase, a widespread pyridoxal 5'-phosphate-coupled desulphonative enzyme purified from Silicibacter pomeroyi DSS-3(T).

  The Biochemical journal 20060315

• NMR studies of solvent-assisted proton transfer in a biologically relevant Schiff base: toward a distinction of geometric and equilibrium H-bond isotope effects.

  Journal of the American Chemical Society 20060315

• Mangafodipir trisodium-enhanced magnetic resonance imaging for evaluation of pancreatic mass and mass-like lesions.

  World journal of gastroenterology 20060314

• P2 antagonist PPADS attenuates responses of thin fiber afferents to static contraction and tendon stretch.

  American journal of physiology. Heart and circulatory physiology 20060301

• Smooth muscle and purinergic contraction of the human, rabbit, rat, and mouse testicular capsule.

  Biology of reproduction 20060301

• Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, vitamin B12, folic acid and vitamin B6.

  Seizure 20060301

• Mutations in antiquitin in individuals with pyridoxine-dependent seizures.

  Nature medicine 20060301

• Children of Latino immigrants, 4-8 years, in rural Nebraska are adequate in vitamin B-6.

  International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20060301

• Allosteric threonine synthase. Reorganization of the pyridoxal phosphate site upon asymmetric activation through S-adenosylmethionine binding to a novel site.

  The Journal of biological chemistry 20060224

• Redox modulation of chemotherapy-induced tumor cell killing and normal tissue toxicity.

  Journal of the National Cancer Institute 20060215

• Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir.

  Journal of the National Cancer Institute 20060215

• Ionization state of pyridoxal 5'-phosphate in D-serine dehydratase, dialkylglycine decarboxylase and tyrosine phenol-lyase and the influence of monovalent cations as inferred by 31P NMR spectroscopy.

  Biochimica et biophysica acta 20060201

• Structural changes accompanying human serum albumin's binding of fatty acids are concerted.

  Biochimica et biophysica acta 20060201

• Activation of P2Y receptor enhances high-molecular compound absorption from rat ileum.

  The Journal of pharmacy and pharmacology 20060201

• Cloning and expression of the pyridoxal 5'-phosphate-dependent aspartate racemase gene from the bivalve mollusk Scapharca broughtonii and characterization of the recombinant enzyme.

  Journal of biochemistry 20060201

• Importance of sanitary environment for growth performance and plasma nutrient homeostasis during the post-weaning period in piglets.

  Archives of animal nutrition 20060201

• Mechanism of alpha-oxoamine synthases: identification of the intermediate Claisen product in the 8-amino-7-oxononanoate synthase reaction.

  Chemical communications (Cambridge, England) 20060107

• Effects of consecutive high-dose alcohol administration on the utilization of sulfur-containing amino acids by rats.

  The Journal of nutritional biochemistry 20060101

• Moderate hyperhomocysteinemia and early-onset central retinal vein occlusion.

  Retina (Philadelphia, Pa.) 20060101

• The magnetic resonance imaging contrast agent mangafodipir exerts antitumor activity via a previously described superoxide dismutase mimetic activity.

  Cancer research 20060101

• Chemical expansion of cofactor activity.

  Nature chemical biology 20060101

• [Mangafodipir trisodium-enhanced magnetic resonance cholangiography for detection of bile leaks].

  Journal de radiologie 20060101

• P2 receptor-stimulation influences axonal outgrowth in the developing hippocampus in vitro.

  Neuroscience 20060101

• A novel low molecular weight alanine aminotransferase from fasted rat liver.

  Biochemistry. Biokhimiia 20060101

• Abnormally high plasma levels of vitamin B6 in children with autism not taking supplements compared to controls not taking supplements.

  Journal of alternative and complementary medicine (New York, N.Y.) 20060101

• Demonstration of extensive GABA synthesis in the small population of GAD positive neurons in cerebellar cultures by the use of pharmacological tools.

  Neurochemistry international 20060101

• [Blocking action of pyridoxal-5'-phosphate on nonadrenergic synaptic inhibition of human small intestine smooth muscle].

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20060101

• B6-responsive disorders: a model of vitamin dependency.

  Journal of inherited metabolic disease 20060101

• Effective NSAID treatment indicates that hyperprostaglandinism is affecting the clinical severity of childhood hypophosphatasia.

  Orphanet journal of rare diseases 20060101

• B-vitamin status and concentrations of homocysteine in Austrian omnivores, vegetarians and vegans.

  Annals of nutrition & metabolism 20060101

• Low pyridoxal 5'-phosphate is associated with increased risk of coronary artery disease.

  Nutrition (Burbank, Los Angeles County, Calif.) 20060101

• Exploring the pyridoxal 5'-phosphate-dependent enzymes.

  Chemical record (New York, N.Y.) 20060101

• Interaction between P2X and nicotinic acetylcholine receptors in glutamate nerve terminals of the rat hippocampus.

  Journal of molecular neuroscience : MN 20060101

• Substrate recognition by the human fatty-acid synthase.

  The Journal of biological chemistry 20051230

• Involvement of P2X receptor subtypes in ATP-induced enhancement of the cough reflex sensitivity.

  European journal of pharmacology 20051228

• Inhibition of acetyl-CoA carboxylase isoforms by pyridoxal phosphate.

  The Journal of biological chemistry 20051223

• The effect of P2X receptor activity on GABAA receptor-mediated inhibition in the gerbil hippocampus.

  Brain research 20051214

• Relationships of Cysteine and Lysine residues with the substrate binding site of the mitochondrial ornithine/citrulline carrier: an inhibition kinetic approach combined with the analysis of the homology structural model.

  Biochimica et biophysica acta 20051210

• The relationship between plasma and red cell B-vitamin concentrations in critically-ill patients.

  Clinical nutrition (Edinburgh, Scotland) 20051201

• Age-dependent changes of pyridoxal phosphate synthesizing enzymes immunoreactivities and activities in the gerbil hippocampal CA1 region.

  Mechanisms of ageing and development 20051201

• Neurally released ATP mediates endothelium-dependent hyperpolarization in the circular smooth muscle cells of chicken anterior mesenteric artery.

  British journal of pharmacology 20051201

• Inherited disorders of neurotransmitters in children and adults.

  Clinical biochemistry 20051201

• Pyridoxal phosphate inhibits the group I intron splicing.

  Molecular and cellular biochemistry 20051201

• Effect of antiepileptic drugs on the urinary excretion of porphyrins in non-porphyric subjects.

  Journal of pharmacological sciences 20051201

• Effects of acute administration of and tachyphylaxis to alpha,beta-methylene ATP in the guinea-pig small intestine.

  Basic & clinical pharmacology & toxicology 20051201

• Purification and characterization of pyridoxine 5'-phosphate phosphatase from Sinorhizobium meliloti.

  Bioscience, biotechnology, and biochemistry 20051201

• Molecular basis of cysteine biosynthesis in plants: structural and functional analysis of O-acetylserine sulfhydrylase from Arabidopsis thaliana.

  The Journal of biological chemistry 20051118

• Structures of Mycobacterium tuberculosispyridoxine 5'-phosphate oxidase and its complexes with flavin mononucleotide and pyridoxal 5'-phosphate.

  Acta crystallographica. Section D, Biological crystallography 20051101

• MC-1 (pyridoxal 5'-phosphate): novel therapeutic applications to reduce ischaemic injury.

  Expert opinion on investigational drugs 20051101

• Determinants of substrate specificity in omega-aminotransferases.

  The Journal of biological chemistry 20051028

• Probing the role of Tyr 64 of Treponema denticola cystalysin by site-directed mutagenesis and kinetic studies.

  Biochemistry 20051025

• Enhancement of spontaneous synaptic activity in rat Purkinje neurones by ATP during development.

  The Journal of physiology 20051001

• Differences in the neurotoxicity profile induced by ATP and ATPgammaS in cultured cerebellar granule neurons.

  Neurochemistry international 20051001

• Properties of human and rabbit cytosolic serine hydroxymethyltransferase are changed by single nucleotide polymorphic mutations.

  Archives of biochemistry and biophysics 20051001

• Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans.

  The EMBO journal 20050921

• On the two components of pyridoxal 5'-phosphate synthase from Bacillus subtilis.

  The Journal of biological chemistry 20050916

• Use of chlorite to improve HPLC detection of pyridoxal 5'-phosphate.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050905

• Roscovitine targets, protein kinases and pyridoxal kinase.

  The Journal of biological chemistry 20050902

• Endogenous ATP involvement in mustard-oil-induced central sensitization in trigeminal subnucleus caudalis (medullary dorsal horn).

  Journal of neurophysiology 20050901

• Direct excitation of hypocretin/orexin cells by extracellular ATP at P2X receptors.

  Journal of neurophysiology 20050901

• P2 receptor blockade attenuates fever and cytokine responses induced by lipopolysaccharide in rats.

  British journal of pharmacology 20050901

• ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells.

  The Journal of clinical investigation 20050901

• Alpha-1B adrenoceptors mediate neurogenic constriction in mesenteric arteries of normotensive and DOCA-salt hypertensive mice.

  Autonomic neuroscience : basic & clinical 20050831

• [MR and biliary tract].

  Ugeskrift for laeger 20050829

• Long-term depression is not modulated by ATP receptors in the rat CA1 hippocampal region.

  Neuroscience letters 20050805

• Functional expression of P2X7 receptors in non-neuronal cells of rat dorsal root ganglia.

  Brain research 20050802

• Folding pathway of the pyridoxal 5'-phosphate C-S lyase MalY from Escherichia coli.

  The Biochemical journal 20050801

• Interaction of serine acetyltransferase with O-acetylserine sulfhydrylase active site: evidence from fluorescence spectroscopy.

  Protein science : a publication of the Protein Society 20050801

• Developmental downregulation of P2X3 receptors in motoneurons of the compact formation of the nucleus ambiguus.

  The European journal of neuroscience 20050801

• A new arrangement of (beta/alpha)8 barrels in the synthase subunit of PLP synthase.

  The Journal of biological chemistry 20050729

• Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor.

  Biochemical pharmacology 20050715

• Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050706

• Clinical vitamin B6 analysis: an interlaboratory comparison of pyridoxal 5'-phosphate measurements in serum.

  Clinical chemistry 20050701

• Changes in P2X3 receptor expression in the trigeminal ganglion following monoarthritis of the temporomandibular joint in rats.

  Pain 20050701

• ATP-gamma-S shifts the operating point of outer hair cell transduction towards scala tympani.

  Hearing research 20050701

• Detection of liver metastases from adenocarcinoma of the colon and pancreas: comparison of mangafodipir trisodium-enhanced liver MRI and whole-body FDG PET.

  AJR. American journal of roentgenology 20050701

• Role of MC-1 alone and in combination with tissue plasminogen activator in focal ischemic brain injury in rats.

  Journal of neurosurgery 20050701

• Oxygen release from low and normal P50 Hb vesicles in transiently occluded arterioles of the hamster window model.

  American journal of physiology. Heart and circulatory physiology 20050601

• Stimulation of P2X receptors enhances lipooligosaccharide-mediated apoptosis of endothelial cells.

  Journal of leukocyte biology 20050601

• Purinergic modulation of cardiovascular function in the rat locus coeruleus.

  British journal of pharmacology 20050601

• Strain relief at the active site of phosphoserine aminotransferase induced by radiation damage.

  Protein science : a publication of the Protein Society 20050601

• Hydrostatic pressure affects the conformational equilibrium of Salmonella typhimurium tryptophan synthase.

  Biochemistry 20050531

• Biochemical characterization of the Campylobacter jejuni Cj1294, a novel UDP-4-keto-6-deoxy-GlcNAc aminotransferase that generates UDP-4-amino-4,6-dideoxy-GalNAc.

  The Journal of biological chemistry 20050527

• Leukotriene and purinergic receptors are involved in the hyperpolarizing effect of glucagon in liver cells.

  Biochimica et biophysica acta 20050515

• Role of Lys-226 in the catalytic mechanism of Bacillus stearothermophilus serine hydroxymethyltransferase--crystal structure and kinetic studies.

  Biochemistry 20050510

• Plasma vitamin B6 and the risk of colorectal cancer and adenoma in women.

  Journal of the National Cancer Institute 20050504

• Spinal P2X receptor modulates reflex pressor response to activation of muscle afferents.

  American journal of physiology. Heart and circulatory physiology 20050501

• Ectonucleoside triphosphate diphosphohydrolase 1/CD39, localized in neurons of human and porcine heart, modulates ATP-induced norepinephrine exocytosis.

  The Journal of pharmacology and experimental therapeutics 20050501

• Varicosity-Schwann cell interactions mediated by ATP in the mouse vas deferens.

  Journal of neurophysiology 20050501

• Effect of a swim training on homocysteine and cysteine levels in rats.

  Amino acids 20050501

• Overexpression of human alanine:glyoxylate aminotransferase in Escherichia coli: renaturation from guanidine-HCl and affinity for pyridoxal phosphate co-factor.

  Protein expression and purification 20050501

• Pyridoxine or pyridoxal phosphate for intractable seizures?

  Archives of disease in childhood 20050501

• Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy.

  Archives of disease in childhood 20050501

• MR cholangiography with manganese dipyridoxyl diphosphate in the evaluation of biliary-enteric anastomoses: preliminary experience.

  AJR. American journal of roentgenology 20050501

• Functional MR cholangiography: diagnosis of functional abnormalities of the gallbladder and biliary tree.

  AJR. American journal of roentgenology 20050501

• On the AJR viewbox. Intrapancreatic accessory spleen: diagnosis with RES-specific contrast-enhanced MRI.

  AJR. American journal of roentgenology 20050501

• Detection of liver metastases from gastrointestinal cancer: comparision of high resolution MnDPDP enhanced MRI and FDG-PET.

  Academic radiology 20050501

• Determination of quality of pyridoxal-5'-phosphate enzyme preparations by spectroscopic methods.

  Journal of pharmaceutical and biomedical analysis 20050429

• Structure of ACC synthase inactivated by the mechanism-based inhibitor L-vinylglycine.

  FEBS letters 20050425

• A comparative study of various computational approaches in calculating the structure of pyridoxal 5'-phosphate (PLP)-dependent beta-lyase protein. The importance of protein environment.

  Journal of computational chemistry 20050415

• Neonatal epileptic encephalopathy caused by mutations in the PNPO gene encoding pyridox(am)ine 5'-phosphate oxidase.

  Human molecular genetics 20050415

• Involvement of uracil nucleotides in protection of cardiomyocytes from hypoxic stress.

  Biochemical pharmacology 20050415

• Biliary atresia: feasibility of mangafodipir trisodium-enhanced MR cholangiography for evaluation.

  Radiology 20050401

• Structure of a pseudomerohedrally twinned monoclinic crystal form of a pyridoxal phosphate-dependent catalytic antibody.

  Acta crystallographica. Section D, Biological crystallography 20050401

• Pathophysiological roles of extracellular nucleotides in glial cells: differential expression of purinergic receptors in resting and activated microglia.

  Brain research. Brain research reviews 20050401

• Traumatic injury activates protein kinase B/Akt in cultured astrocytes: role of extracellular ATP and P2 purinergic receptors.

  Journal of neurotrauma 20050401

• Connexin26 is responsible for anionic molecule permeability in the cochlea for intercellular signalling and metabolic communications.

  The European journal of neuroscience 20050401

• Correlation between dietary polyunsaturated fatty acids and plasma homocysteine concentration in vitamin B6-deficient rats.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20050401

• Role of vitamins B6, B12 and folic acid on hyperhomocysteinemia in a Pakistani population of patients with acute myocardial infarction.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20050401

• P2 receptor antagonist PPADS confers neuroprotection against glutamate/NMDA toxicity.

  Neuroscience letters 20050329

• Decrypting the biochemical function of an essential gene from Streptococcus pneumoniae using ThermoFluor technology.

  The Journal of biological chemistry 20050325

• Reconstitution and biochemical characterization of a new pyridoxal-5'-phosphate biosynthetic pathway.

  Journal of the American Chemical Society 20050323

• Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor.

  The Journal of biological chemistry 20050304

• Red cell aspartate aminotransferase saturation with oral pyridoxine intake.

  Sao Paulo medical journal = Revista paulista de medicina 20050302

• Crystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver.

  Protein science : a publication of the Protein Society 20050301

• Isolation and characterization of a D-cysteine desulfhydrase protein from Arabidopsis thaliana.

  The FEBS journal 20050301

• Double gallbladder diagnosed on contrast-enhanced MR cholangiography with mangafodipir trisodium.

  AJR. American journal of roentgenology 20050301

• Effects of chemical modification of lysine residues on the sweetness of lysozyme.

  Chemical senses 20050301

• Myosin light chain kinase and Rho-kinase participate in P2Y receptor-mediated acceleration of permeability through the endothelial cell layer.

  The Journal of pharmacy and pharmacology 20050301

• Pharmacological characterization of P2X7 receptors in rat peritoneal cells.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050301

• Potentiation of sympathetic neuromuscular transmission mediated by muscarinic receptors in guinea pig isolated vas deferens.

  Naunyn-Schmiedeberg's archives of pharmacology 20050301

• The influence of hypothermia on P2 receptor-mediated responses of frog skeletal muscle.

  European journal of pharmacology 20050221

• Characterization of the NifS-like domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration.

  The Journal of biological chemistry 20050211

• Vitamin B6 compounds prevent the death of yeast cells due to menadione, a reactive oxygen generator.

  Biochimica et biophysica acta 20050211

• The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site.

  Biochemistry 20050208

• Dynamics of fast synaptic excitation during trains of stimulation in myenteric neurons of guinea-pig ileum.

  Autonomic neuroscience : basic & clinical 20050207

• Release of ATP in the ventral medulla during hypoxia in rats: role in hypoxic ventilatory response.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050202

• Evolution of vitamin B6 (pyridoxine) metabolism by gain and loss of genes.

  Molecular biology and evolution 20050201

• Lys-64 of the A chain is involved in the enzymatic activity and neurotoxic effect of beta-bungarotoxin.

  Toxicon : official journal of the International Society on Toxinology 20050201

• Evidence for the involvement of endogenous ATP and P2X receptors in TMJ pain.

  European journal of pain (London, England) 20050201

• Stabilizing effects of extracellular ATP on synaptic efficacy and plasticity in hippocampal pyramidal neurons.

  The European journal of neuroscience 20050201

• Inactivation of brain myo-inositol monophosphate phosphatase by pyridoxal-5'-phosphate.

  Journal of biochemistry and molecular biology 20050131

• Acidosis attenuates P2X purinergic vasoconstriction in skeletal muscle arteries.

  American journal of physiology. Heart and circulatory physiology 20050101

• Pyridoxal phosphate and hepatocyte growth factor prevent dialysate-induced peritoneal damage.

  Journal of the American Society of Nephrology : JASN 20050101

• Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein.

  Archives of biochemistry and biophysics 20050101

• The enzymology of cystathionine biosynthesis: strategies for the control of substrate and reaction specificity.

  Archives of biochemistry and biophysics 20050101

• Reaction specificity in pyridoxal phosphate enzymes.

  Archives of biochemistry and biophysics 20050101

• Manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging of acute reperfused myocardial injury in a cat model: part I: comparison with pathologic examination.

  Investigative radiology 20050101

• Manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging of acute reperfused myocardial injury in a cat model: part II: comparison with cine magnetic resonance imaging.

  Investigative radiology 20050101

• A phosphatase for cofilin to be HAD.

  Nature cell biology 20050101

• Secretion of ATP from Schwann cells in response to uridine triphosphate.

  The European journal of neuroscience 20050101

• Bile duct leaks after laparoscopic cholecystectomy: value of contrast-enhanced MRCP.

  Abdominal imaging 20050101

• Mice have a transcribed L-threonine aldolase/GLY1 gene, but the human GLY1 gene is a non-processed pseudogene.

  BMC genomics 20050101

• Characterization of hepatocellular tumors: value of mangafodipir-enhanced magnetic resonance imaging.

  Journal of computer assisted tomography 20050101

• Adult hypophosphatasia and a low level of red blood cell thiamine pyrophosphate.

  Annals of nutrition & metabolism 20050101

• Plasma pyridoxal 5'-phosphate is a significant indicator of immune responses in the mechanically ventilated critically ill.

  Nutrition (Burbank, Los Angeles County, Calif.) 20050101

• Pipecolic acid concentrations in brain tissue of nutritionally pyridoxine-deficient rats.

  Journal of inherited metabolic disease 20050101

• Hepatocyte-targeted MR contrast agents: contrast enhanced detection of liver cancer in diffusely damaged liver.

  Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 20050101

• Neuroprotective effects of inhibiting N-methyl-D-aspartate receptors, P2X receptors and the mitogen-activated protein kinase cascade: a quantitative analysis in organotypical hippocampal slice cultures subjected to oxygen and glucose deprivation.

  Neuroscience 20050101

• Gadobenate dimeglumine as an intrabiliary contrast agent: comparison with mangafodipir trisodium with respect to non-dilated biliary tree depiction.

  Korean journal of radiology 20050101

• Site-directed mutagenesis of human brain GABA transaminase: lysine-357 is involved in cofactor binding at the active site.

  Molecules and cells 20041231

• The reaction of indole with the aminoacrylate intermediate of Salmonella typhimurium tryptophan synthase: observation of a primary kinetic isotope effect with 3-[(2)H]indole.

  Archives of biochemistry and biophysics 20041215

• PLPMDB: pyridoxal-5'-phosphate dependent enzymes mutants database.

  Bioinformatics (Oxford, England) 20041212

• The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum.

  The Journal of biological chemistry 20041210

• Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol.

  Biochemical and biophysical research communications 20041203

• Divergent effects of the purinoceptor antagonists suramin and pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8'-disulfonate) (PPNDS) on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.

  Molecular pharmacology 20041201

• Defining intrahepatic biliary anatomy in living liver transplant donor candidates at mangafodipir trisodium-enhanced MR cholangiography versus conventional T2-weighted MR cholangiography.

  Radiology 20041201

• Early biliary complications of laparoscopic cholecystectomy: evaluation on T2-weighted MR cholangiography in conjunction with mangafodipir trisodium-enhanced 3D T1-weighted MR cholangiography.

  AJR. American journal of roentgenology 20041201

• [MRT of the liver. Clinical significance of nonspecific and liver-specific MRT contrast agents].

  Der Radiologe 20041201

• Relaxation enhancing properties of MnDPDP in human myocardium.

  Journal of magnetic resonance imaging : JMRI 20041201

• Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels.

  The European journal of neuroscience 20041201

• Manganese toxicity upon overexposure.

  NMR in biomedicine 20041201

• Interaction between muscle aldolase and muscle fructose 1,6-bisphosphatase results in the substrate channeling.

  Biochemistry 20041130

• Role of lysine-256 in Citrobacter freundii tyrosine phenol-lyase in monovalent cation activation.

  Biochemistry 20041116

• Mechanistic crystallography. Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid as elucidated by crystallography.

  Biochemistry 20041109

• Cardiovascular responses to microinjection of ATP into the nucleus tractus solitarii of awake rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20041101

• Purinergic modulation of extracellular glutamate levels in the nucleus accumbens in vivo.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20041101

• Evidence for P2Y1, P2Y2, P2Y6 and atypical UTP-sensitive receptors coupled to rises in intracellular calcium in mouse cultured superior cervical ganglion neurons and glia.

  British journal of pharmacology 20041101

• Anti-angiogenic effect of pyridoxal 5'-phosphate, pyridoxal and pyridoxamine on embryoid bodies derived from mouse embryonic stem cells.

  International journal of molecular medicine 20041101

• Preoperative evaluation of biliary anatomy in adult live liver donors with volumetric mangafodipir trisodium enhanced magnetic resonance cholangiography.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20041101

• Evolutionarily conserved regions and hydrophobic contacts at the superfamily level: The case of the fold-type I, pyridoxal-5'-phosphate-dependent enzymes.

  Protein science : a publication of the Protein Society 20041101

• Coexpression, purification and characterization of the E and S subunits of coenzyme B(12) and B(6) dependent Clostridium sticklandii D-ornithine aminomutase in Escherichia coli.

  European journal of biochemistry 20041101

• Structural analysis of Pseudomonas 1-aminocyclopropane-1-carboxylate deaminase complexes: insight into the mechanism of a unique pyridoxal-5'-phosphate dependent cyclopropane ring-opening reaction.

  Biochemistry 20041026

• Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice.

  Neuroreport 20041025

• Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase.

  Biochemistry 20041019

• Clinical analysis of vitamin B(6): determination of pyridoxal 5'-phosphate and 4-pyridoxic acid in human serum by reversed-phase high-performance liquid chromatography with chlorite postcolumn derivatization.

  Analytical biochemistry 20041015

• The relationship between plasma and red cell concentrations of vitamins thiamine diphosphate, flavin adenine dinucleotide and pyridoxal 5-phosphate following elective knee arthroplasty.

  Clinical nutrition (Edinburgh, Scotland) 20041001

• MRI for detection of hepatocellular carcinoma: comparison of mangafodipir trisodium and gadopentetate dimeglumine contrast agents.

  AJR. American journal of roentgenology 20041001

• Detection and characterization of focal hepatic lesions: mangafodipir vs. superparamagnetic iron oxide-enhanced magnetic resonance imaging.

  Journal of magnetic resonance imaging : JMRI 20041001

• Kinetic and structural characterization of Slr0077/SufS, the essential cysteine desulfurase from Synechocystis sp. PCC 6803.

  Biochemistry 20040928

• Mechanism of cysteine desulfurase Slr0387 from Synechocystis sp. PCC 6803: kinetic analysis of cleavage of the persulfide intermediate by chemical reductants.

  Biochemistry 20040928

• Mechanism of 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase, a key enzyme in the methanopterin biosynthetic pathway.

  The Journal of biological chemistry 20040917

• Role of extracellular histidines in antagonist sensitivity of the rat P2X4 receptor.

  Neuroscience letters 20040902

• Effect of long-term, high-copper intake on the concentrations of plasma homocysteine and B vitamins in young men.

  Nutrition (Burbank, Los Angeles County, Calif.) 20040901

• Claisen-type addition of glycine to pyridoxal in water.

  Journal of the American Chemical Society 20040901

• Purinergic component of mechanosensory transduction is increased in a rat model of colitis.

  American journal of physiology. Gastrointestinal and liver physiology 20040901

• Magnetic resonance with manganese-DPDP (mangafodipir) of focal solid pancreatic lesions.

  La Radiologia medica 20040901

• Plasma folate as marker of folate status in epidemiological studies: the European Investigation into Cancer and Nutrition (EPIC)-Potsdam study.

  The British journal of nutrition 20040901

• Crystal structures of unbound and aminooxyacetate-bound Escherichia coli gamma-aminobutyrate aminotransferase.

  Biochemistry 20040831

• P2 receptors modulate respiratory rhythm but do not contribute to central CO2 sensitivity in vitro.

  Respiratory physiology & neurobiology 20040820

• Circulating half-life of PEGylated recombinant methioninase holoenzyme is highly dose dependent on cofactor pyridoxal-5'-phosphate.

  Cancer research 20040815

• Following an ISES lead: the first examples of asymmetric Ni(0)-mediated allylic amination.

  Organic letters 20040805

• ATP downregulates P2X7 and inhibits osteoclast formation in RAW cells.

  American journal of physiology. Cell physiology 20040801

• The C-terminus of rat L-histidine decarboxylase specifically inhibits enzymic activity and disrupts pyridoxal phosphate-dependent interactions with L-histidine substrate analogues.

  The Biochemical journal 20040801

• Homocysteine, vitamin B6, and endothelial dysfunction in circulatory disorders.

  Stroke 20040801

• P2X7 receptor inhibition improves recovery after spinal cord injury.

  Nature medicine 20040801

• Contrast-enhanced magnetic resonance cholangiography using mangafodipir compared with standard T2W MRC sequences: a pictorial essay.

  Journal of magnetic resonance imaging : JMRI 20040801

• Relationships between structure, function and stability for pyridoxal 5'-phosphate-dependent starch phosphorylase from Corynebacterium callunae as revealed by reversible cofactor dissociation studies.

  European journal of biochemistry 20040801

• Activation of serum aminotransferases by pyridoxal-5' -phosphate in epileptic patients treated with anticonvulsant drugs.

  Clinical biochemistry 20040801

• Induction of apoptosis in bone marrow cells is mediated via purinergic receptors.

  Bulletin of experimental biology and medicine 20040801

• Crystal structure and reactivity of YbdL from Escherichia coli identify a methionine aminotransferase function.

  FEBS letters 20040730

• Bacillus subtilis GabR, a protein with DNA-binding and aminotransferase domains, is a PLP-dependent transcriptional regulator.

  Journal of molecular biology 20040716

• Visualization of PLP-bound intermediates in hemeless variants of human cystathionine beta-synthase: evidence that lysine 119 is a general base.

  Archives of biochemistry and biophysics 20040715

• Cloning, expression, and characterization of 5-aminolevulinic acid synthase from Rhodopseudomonas palustris KUGB306.

  FEMS microbiology letters 20040715

• A natural compound (reuterin) produced by Lactobacillus reuteri for hemoglobin polymerization as a blood substitute.

  Biotechnology and bioengineering 20040705

• Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes.

  Arteriosclerosis, thrombosis, and vascular biology 20040701

• MR imaging of the stomach: potential use for mangafodipir trisodium--a study in swine.

  Radiology 20040701

• Effects of different dietary amounts of LCPUFA n3 and vitamin B6 on lipid composition and antioxidant defences in rat kidney.

  The Journal of nutritional biochemistry 20040701

• ATP augments von Willebrand factor-dependent shear-induced platelet aggregation through Ca2+-calmodulin and myosin light chain kinase activation.

  The Journal of biological chemistry 20040618

• Diagnosing biliary complications of orthotopic liver transplantation with mangafodipir trisodium-enhanced MR cholangiography: comparison with conventional MR cholangiography.

  AJR. American journal of roentgenology 20040601

• Identification of functionally important residues in the pyridoxal-5'-phosphate-dependent catalytic antibody 15A9.

  Biochemistry 20040601

• Mangafodipir-enhanced magnetic resonance cholangiography for the diagnosis of bile duct leaks.

  Gastrointestinal endoscopy 20040601

• P2Y receptor-mediated Ca(2+) signaling increases human vascular endothelial cell permeability.

  Journal of pharmacological sciences 20040601

• Identification and staging of pancreatic tumours using computed tomography, endoscopic ultrasound and mangafodipir trisodium-enhanced magnetic resonance imaging.

  Australasian radiology 20040601

• Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040519

• Mangan-enhanced MR imaging for the detection and localisation of small pancreatic insulinoma.

  European radiology 20040501

• Assessment of sequential enhancement patterns of focal nodular hyperplasia and hepatocellular carcinoma on mangafodipir trisodium enhanced MR imaging.

  Investigative radiology 20040501

• Antioxidant activity of mangafodipir is not a new finding.

  Journal of hepatology 20040501

• Small (<or= 2 cm) hepatic lesions in colorectal cancer patients: detection and characterization on mangafodipir trisodium-enhanced MRI.

  AJR. American journal of roentgenology 20040501

• Uptake of MnCl2 and mangafodipir trisodium in the myocardium: a magnetic resonance imaging study in pigs.

  Journal of magnetic resonance imaging : JMRI 20040501

• Functional maturation of isolated neural progenitor cells from the adult rat hippocampus.

  The European journal of neuroscience 20040501

• Hemoglobin polymerized with a naturally occurring crosslinking agent as a blood substitute: in vitro and in vivo studies.

  Artificial cells, blood substitutes, and immobilization biotechnology 20040501

• The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes.

  The Journal of biological chemistry 20040423

• ATP participates in three excitatory postsynaptic potentials in the submucous plexus of the guinea pig ileum.

  The Journal of physiology 20040415

• Mn-DPDP-enhanced 24-h delayed-scan MRI of hepatocellular carcinoma is correlated with histology.

  European radiology 20040401

• Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications.

  European radiology 20040401

• Clinical aspects of the disorders of GABA metabolism in children.

  Current opinion in neurology 20040401

• Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons.

  Pain 20040401

• Enteric P2X receptors as potential targets for drug treatment of the irritable bowel syndrome.

  British journal of pharmacology 20040401

• Analysis of antibody reactivity against cysteine sulfinic acid decarboxylase, a pyridoxal phosphate-dependent enzyme, in endocrine autoimmune disease.

  The Journal of clinical endocrinology and metabolism 20040401

• P2 receptor-mediated effects on the open field behaviour of rats in comparison with behavioural responses induced by the stimulation of dopamine D2-like and by the blockade of ionotrophic glutamate receptors.

  Behavioural brain research 20040302

• Synthesis of nitric oxide in postganglionic myenteric neurons during endotoxemia: implications for gastric motor function in rats.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040301

• Purinergic modulation of cochlear partition resistance and its effect on the endocochlear potential in the Guinea pig.

  Journal of the Association for Research in Otolaryngology : JARO 20040301

• Biliary tract depiction in living potential liver donors: comparison of conventional MR, mangafodipir trisodium-enhanced excretory MR, and multi-detector row CT cholangiography--initial experience.

  Radiology 20040301

• A successful treatment with pyridoxal phosphate for West syndrome in hypophosphatasia.

  Pediatric neurology 20040301

• [3H]alpha,beta-methylene ATP binding to P2X purinoceptor is unaffected by volatile anaesthetics.

  European journal of anaesthesiology 20040301

• Elevated plasma total homocysteine in centenarians.

  Clinical chemistry and laboratory medicine 20040301

• [Detection of liver metastases in colorectal cancer on chemotherapy. Comparative study between MRI with teslascan and computed tomography with intravenous contrast media].

  Journal de radiologie 20040301

• Effect of PPADS on P2X receptor-mediated responses of human blood vessels.

  Bulletin of experimental biology and medicine 20040301

• Effect of age on plasma homocysteine concentrations in young and elderly subjects considering serum vitamin concentrations and different lifestyle factors.

  International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20040301

• Characterization of the cofactor composition of Escherichia coli biotin synthase.

  Biochemistry 20040224

• Effect of vitamin B6 on oxygen radicals, mitochondrial membrane potential, and lipid peroxidation in H2O2-treated U937 monocytes.

  Free radical biology & medicine 20040215

• Three-dimensional structure of kynureninase from Pseudomonas fluorescens.

  Biochemistry 20040210

• G-1:C73 recognition by an arginine cluster in the active site of Escherichia coli histidyl-tRNA synthetase.

  Biochemistry 20040203

• Do P2X purinergic receptors regulate skeletal muscle blood flow during exercise?

  American journal of physiology. Heart and circulatory physiology 20040201

• Vitamin B6 metabolites in idiopathic calcium stone formers: no evidence for a link to hyperoxaluria.

  Urological research 20040201

• Disruption of the plr1+ gene encoding pyridoxal reductase of Schizosaccharomyces pombe.

  Journal of biochemistry 20040201

• Three-dimensional structure of YaaE from Bacillus subtilis, a glutaminase implicated in pyridoxal-5'-phosphate biosynthesis.

  The Journal of biological chemistry 20040123

• Ion transport across Xenopus alveolar epithelium is regulated by extracellular ATP, UTP and adenosine.

  Respiratory physiology & neurobiology 20040115

• Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin.

  The Journal of biological chemistry 20040102

• Discrete but simultaneous release of adenine nucleotides and serotonin from mouse megakaryocytes as detected with patch- and carbon-fiber electrodes.

  American journal of physiology. Cell physiology 20040101

• Inflammation, homocysteine, and vitamin B6 status after ischemic stroke.

  Stroke 20040101

• Plasma taurine and cysteine levels following an oral methionine load: relationship with coronary heart disease.

  European journal of clinical nutrition 20040101

• Clinical and nutritional correlates of C-reactive protein in type 2 diabetic nephropathy.

  Atherosclerosis 20040101

• Modulation of feeding behaviour by blocking purinergic receptors in the rat nucleus accumbens: a combined microdialysis, electroencephalographic and behavioural study.

  The European journal of neuroscience 20040101

• Detection of colorectal liver metastases: a prospective multicenter trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT.

  European radiology 20040101

• [Contribution of MR cholangiography after Teslascan infusion for the diagnosis of post-traumatic biliary injury].

  Gastroenterologie clinique et biologique 20040101

• Cytosolic NADP phosphatases I and II from Arthrobacter sp. strain KM: implication in regulation of NAD+/NADP+ balance.

  Journal of basic microbiology 20040101

• Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations.

  Annual review of biochemistry 20040101

• Evaluation of vitamin B6 status and RDA in young Koreans.

  Annals of nutrition & metabolism 20040101

• Cooperation in signal transduction of extracellular guanosine 5' triphosphate and nerve growth factor in neuronal differentiation of PC12 cells.

  Neuroscience 20040101

• Vitamin B6 level is associated with symptoms of depression.

  Psychotherapy and psychosomatics 20040101

• Magnetic resonance cholangiography with mangafodipir trisodium (Teslascan) to evaluate bile duct leaks after T-tube removal in liver transplantation.

  Journal of computer assisted tomography 20040101

• [Influence of pyridoxal phosphate in measuring aminotransferases activities in patients with viral hepatitis].

  Annales de biologie clinique 20040101

• Pyridoxal 5'-phosphate is a selective inhibitor in vivo of DNA polymerase alpha and epsilon.

  Biochemical and biophysical research communications 20031226

• Crystal structure at 1.45 A resolution of alanine racemase from a pathogenic bacterium, Pseudomonas aeruginosa, contains both internal and external aldimine forms.

  Biochemistry 20031223

• The nature of the rate-limiting steps in the refolding of the cofactor-dependent protein aspartate aminotransferase.

  The Journal of biological chemistry 20031212

• Irwin C. Gunsalus, versatile and creative scientist.

  Biochemical and biophysical research communications 20031205

• The discovery, synthesis, and role of pyridoxal phosphate: phase I of many phases in the Gunsalus odyssey.

  Biochemical and biophysical research communications 20031205

• Mechanotransduction by intraganglionic laminar endings of vagal tension receptors in the guinea-pig oesophagus.

  The Journal of physiology 20031201

• Pyridoxal 5'-phosphate as a novel weapon against autoimmunity and transplant rejection.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031201

• In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation.

  Cancer research 20031201

• Cell-specific behavior of P2X7 receptors in mouse parotid acinar and duct cells.

  The Journal of biological chemistry 20031128

• Treponema denticola cystalysin catalyzes beta-desulfination of L-cysteine sulfinic acid and beta-decarboxylation of L-aspartate and oxalacetate.

  FEBS letters 20031120

• Crystal structure of serine dehydratase from rat liver.

  Biochemistry 20031111

• ATP modulates intracellular Ca2+ and firing rate through a P2Y1 purinoceptor in cane toad pacemaker cells.

  The Journal of physiology 20031101

• Functional evidence that ATP or a related purine is an inhibitory NANC neurotransmitter in the mouse jejunum: study on the identity of P2X and P2Y purinoceptors involved.

  British journal of pharmacology 20031101

• Mangafodipir prevents liver injury induced by acetaminophen in the mouse.

  Journal of hepatology 20031101

• P2X receptor-mediated excitatory synaptic currents in somatosensory cortex.

  Molecular and cellular neurosciences 20031101

• Interaction between pyridoxal kinase and pyridoxal-5-phosphate-dependent enzymes.

  Journal of biochemistry 20031101

• Crystal structure of Escherichia coli PdxA, an enzyme involved in the pyridoxal phosphate biosynthesis pathway.

  The Journal of biological chemistry 20031031

• Presence of functional ATP and dinucleotide receptors in glutamatergic synaptic terminals from rat midbrain.

  Journal of neurochemistry 20031001

• Functional magnetic resonance cholangiography (fMRC) of the gallbladder and biliary tree with contrast-enhanced magnetic resonance cholangiography.

  Journal of magnetic resonance imaging : JMRI 20031001

• Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive type 1 diabetes.

  The Journal of clinical endocrinology and metabolism 20031001

• Avoiding the road less traveled: how the topology of enzyme-substrate complexes can dictate product selection.

  Accounts of chemical research 20031001

• Vitamin and homocysteine status of mothers and infants and the risk of nonsyndromic orofacial clefts.

  American journal of obstetrics and gynecology 20031001

• Lysine 238 is an essential residue for alpha,beta-elimination catalyzed by Treponema denticola cystalysin.

  The Journal of biological chemistry 20030926

• Reduction of myocardial ischemic injury following coronary intervention (the MC-1 to Eliminate Necrosis and Damage trial).

  The American journal of cardiology 20030915

• Activation of purinergic receptor subtypes modulates odor sensitivity.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030910

• Modeling and molecular dynamics of glutamine transaminase K/cysteine conjugate beta-lyase.

  Journal of molecular graphics & modelling 20030901

• ATP augments peptide release from rat sensory neurons in culture through activation of P2Y receptors.

  The Journal of pharmacology and experimental therapeutics 20030901

• Early glial cell reactivity in experimental retinal detachment: effect of suramin.

  Investigative ophthalmology & visual science 20030901

• A genomic overview of pyridoxal-phosphate-dependent enzymes.

  EMBO reports 20030901

• [Comparative study of four GRE sequences in MnDPDP-enhanced magnetic resonance imaging for primary hepatocellular carcinoma].

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030901

• Intraoperative contrast-enhanced MR-imaging as predictor of tissue damage during cryoablation of porcine liver.

  Magnetic resonance imaging 20030901

• Conversion of a PLP-dependent racemase into an aldolase by a single active site mutation.

  Journal of the American Chemical Society 20030827

• Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1.

  Journal of molecular biology 20030815

• Design and synthesis of novel pyridoxine 5'-phosphonates as potential antiischemic agents.

  Journal of medicinal chemistry 20030814

• Neurobiology: new player in pain.

  Nature 20030814

• P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury.

  Nature 20030814

• P2Y(2) receptor elicits PAS-positive glycoprotein secretion from rabbit conjunctival goblet cells in vivo.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030801

• Disruption of distal interactions of Arg 262 and of substrate binding to Ser 52 affect catalysis of sheep liver cytosolic serine hydroxymethyltransferase.

  Indian journal of biochemistry & biophysics 20030801

• Differential properties of astrocyte calcium waves mediated by P2Y1 and P2Y2 receptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030730

• Optimisation and validation of a sensitive high-performance liquid chromatography assay for routine measurement of pyridoxal 5-phosphate in human plasma and red cells using pre-column semicarbazide derivatisation.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030725

• Ectonucleotidase in sympathetic nerve endings modulates ATP and norepinephrine exocytosis in myocardial ischemia.

  The Journal of pharmacology and experimental therapeutics 20030701

• Inhibitory effect of pyridoxal 5'-phosphate on endothelial cell proliferation, replicative DNA polymerase and DNA topoisomerase.

  International journal of molecular medicine 20030701

• Structure and properties of recombinant human pyridoxine 5'-phosphate oxidase.

  Protein science : a publication of the Protein Society 20030701

• Safety and efficacy of Mangafodipir trisodium in patients with liver lesions and cirrhosis.

  European radiology 20030701

• B vitamin status and inflammatory markers.

  Atherosclerosis 20030701

• Improved image contrast with mangafodipir trisodium (MnDPDP) during MR-guided percutaneous cryosurgery of the liver.

  Magnetic resonance imaging 20030701

• Comparison of P2 receptor subtypes producing dilation in rat intracerebral arterioles.

  Stroke 20030601

• Low vitamin B6 but not homocyst(e)ine is associated with increased risk of stroke and transient ischemic attack in the era of folic acid grain fortification.

  Stroke 20030601

• Expression of a Brassic napus glutamate 1-semialdehyde aminotransferase in Escherichia coli and characterization of the recombinant protein.

  Protein expression and purification 20030601

• TNP-ATP-resistant P2X ionic current on the central terminals and somata of rat primary sensory neurons.

  Journal of neurophysiology 20030601

• Noninvasive preoperative evaluation of biliary anatomy in right-lobe living donors with mangafodipir trisodium-enhanced MR cholangiography.

  Transplantation proceedings 20030601

• Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae.

  The Journal of biological chemistry 20030523

• Neonatal epileptic encephalopathy.

  Lancet (London, England) 20030510

• P2Y receptor specific for diadenosine tetraphosphate in lung: selective inhibition by suramin, PPADS, Ip5I, and not by MRS-2197.

  European journal of pharmacology 20030502

• Acute cholecystitis at T2-weighted and manganese-enhanced T1-weighted MR cholangiography: preliminary study.

  Radiology 20030501

• Enhanced P2Y1 receptor expression in the brain after sensitisation with d-amphetamine.

  Psychopharmacology 20030501

• A novel pyrroline-5-carboxylic acid and acetoacetic acid adduct in hyperprolinaemia type II.

  Clinica chimica acta; international journal of clinical chemistry 20030501

• Crystallization and preliminary X-ray crystallographic analysis of d-phenylglycine aminotransferase from Pseudomonas stutzeri ST201.

  Acta crystallographica. Section D, Biological crystallography 20030501

• Pyridoxine-dependent seizures: a clinical and biochemical conundrum.

  Biochimica et biophysica acta 20030411

• Structure of 1-aminocyclopropane-1-carboxylate synthase in complex with an amino-oxy analogue of the substrate: implications for substrate binding.

  Biochimica et biophysica acta 20030411

• Structure and mechanism of Escherichia coli pyridoxine 5'-phosphate oxidase.

  Biochimica et biophysica acta 20030411

• Stereospecificity of alpha-proton exchange reactions catalysed by pyridoxal-5'-phosphate-dependent enzymes.

  Biochimica et biophysica acta 20030411

• Phosphate group binding 'cup' of PLP-dependent and non-PLP-dependent enzymes: leitmotif and variations.

  Biochimica et biophysica acta 20030411

• Release of pyridoxal 5'-phosphate upon unfolding of mitochondrial aspartate aminotransferase.

  Biochimica et biophysica acta 20030411

• Crystal structures of branched-chain amino acid aminotransferase complexed with glutamate and glutarate: true reaction intermediate and double substrate recognition of the enzyme.

  Biochemistry 20030408

• Effect of L-dopa on plasma homocysteine in PD patients: relationship to B-vitamin status.

  Neurology 20030408

• Tautomeric equilibria of pyridoxal-5'-phosphate (vitamin B6) and 3-hydroxypyridine derivatives: a theoretical study of solvation effects.

  The Journal of organic chemistry 20030404

• Noncovalent binding of a reaction intermediate by a designed helix-loop-helix motif-implications for catalyst design.

  Chembiochem : a European journal of chemical biology 20030404

• Role played by purinergic receptors on muscle afferents in evoking the exercise pressor reflex.

  Journal of applied physiology (Bethesda, Md. : 1985) 20030401

• Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells.

  The Journal of clinical endocrinology and metabolism 20030401

• ATP released from astrocytes during swelling activates chloride channels.

  Journal of neurophysiology 20030401

• A case of nonconvulsive status epilepticus associated with focal cortical dysplasia.

  Brain & development 20030401

• Pyridoxal phosphate inhibits dynamic subunit interchange among serine hydroxymethyltransferase tetramers.

  The Journal of biological chemistry 20030321

• ATP-induced, sustained calcium signalling in cultured rat cortical astrocytes: evidence for a non-capacitative, P2X7-like-mediated calcium entry.

  FEBS letters 20030313

• ATP-induced calcium oscillations and change of P2Y subtypes with culture conditions in HeLa cells.

  Cell biochemistry and function 20030301

• The evaluation of C-reactive protein, homocysteine and vitamin B6 concentrations in Behçet and rheumatoid arthritis disease.

  Clinica chimica acta; international journal of clinical chemistry 20030301

• Pyridoxal phosphate decreases in plasma but not erythrocytes during systemic inflammatory response.

  Clinical chemistry 20030301

• [Acceleration of ATP-induced contraction in the obstructed bladder of the rat].

  Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 20030301

• P2Y-receptor regulates size of endothelial cells in an intracellular Ca2+ dependent manner.

  Life sciences 20030214

• Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid can antagonize the purinoceptor-mediated inhibition of M-current in bullfrog sympathetic neurons.

  Neuroscience letters 20030206

• Identification of amino acid residues, essential for maintaining the tetrameric structure of sheep liver cytosolic serine hydroxymethyltransferase, by targeted mutagenesis.

  The Biochemical journal 20030201

• Purinergic modulation of neuronal activity in the mesolimbic dopaminergic system in vivo.

  Synapse (New York, N.Y.) 20030201

• P2Y receptor-mediated inhibition of voltage-dependent Ca2+ channels in rat dorsal root ganglion neurons.

  Synapse (New York, N.Y.) 20030201

• PPNDS is an agonist, not an antagonist, for the ATP receptor of Paramecium.

  The Journal of experimental biology 20030201

• Cutaneous metabolism of vitamin B-6.

  The Journal of investigative dermatology 20030201

• Distinctive interactions in the holoenzyme formation for two isoforms of glutamate decarboxylase.

  Biochimica et biophysica acta 20030131

• Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction.

  Biochemistry 20030114

• Cloning, tissue distribution and functional characterization of the chicken P2X1 receptor.

  FEBS letters 20030102

• P2Y(1) receptor activation inhibits NMDA receptor-channels in layer V pyramidal neurons of the rat prefrontal and parietal cortex.

  Neurochemistry international 20030101

• Presence of diadenosine polyphosphates in the aqueous humor: their effect on intraocular pressure.

  The Journal of pharmacology and experimental therapeutics 20030101

• Structure of a yeast hypothetical protein selected by a structural genomics approach.

  Acta crystallographica. Section D, Biological crystallography 20030101

• Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.

  Clinical chemistry 20030101

• Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26.

  Cell calcium 20030101

• Analysis of purinergic and cholinergic fast synaptic transmission to identified myenteric neurons.

  Neuroscience 20030101

• MnDPDP-enhanced magnetization transfer MR imaging: implications for effective liver imaging.

  Magnetic resonance imaging 20030101

• P2 receptors in satellite glial cells in trigeminal ganglia of mice.

  Neuroscience 20030101

• Prognostic value of tryptophan load test followed by serum kynurenine determination. Its comparison with pyridoxal-5-phosphate, kynurenine, homocysteine and neopterin amounts.

  Advances in experimental medicine and biology 20030101

• On the role of alphaThr183 in the allosteric regulation and catalytic mechanism of tryptophan synthase.

  Journal of molecular biology 20021206

• Temperature dependency of P2 receptor-mediated responses.

  European journal of pharmacology 20021205

• Atypical focal nodular hyperplasia of the liver: imaging features of nonspecific and liver-specific MR contrast agents.

  AJR. American journal of roentgenology 20021201

• Evaluation of focal pancreatic masses: comparison of mangafodipir-enhanced MR imaging and contrast-enhanced helical CT.

  European radiology 20021201

• Resetting intrinsic purinergic modulation of neural activity: an associative mechanism?

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20021201

• T1 efficacy of EVP-ABD: a potential manganese-based MR contrast agent for hepatic vascular and tissue phase imaging.

  Journal of magnetic resonance imaging : JMRI 20021201

• A rhythmic motor pattern activated by circumferential stretch in guinea-pig distal colon.

  The Journal of physiology 20021201

• Breast carcinoma metastases to the liver simulating cirrhosis.

  Radiology 20021201

• MnDPDP enhanced magnetic resonance imaging of focal liver lesions.

  Clinical radiology 20021201

• Degradation pathway of the phosphonate ciliatine: crystal structure of 2-aminoethylphosphonate transaminase.

  Biochemistry 20021105

• P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangial proliferative glomerulonephritis.

  Kidney international 20021101

• Pyridoxal-5'-phosphate-dependent catalytic antibodies.

  Journal of immunological methods 20021101

• Intrahepatic biliary anatomy of living adult liver donors: correlation of mangafodipir trisodium-enhanced MR cholangiography and intraoperative cholangiography.

  AJR. American journal of roentgenology 20021101

• Homocysteine, cysteine, and B vitamins as predictors of kidney disease progression.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20021101

• Human Ntera-2/D1 neuronal progenitor cells endogenously express a functional P2Y1 receptor.

  Neuropharmacology 20021101

• [Focal secondary malignant liver lesions: MnDPDP-enhanced MRT at 0.2 tesla vs. helical CT-arterioportography].

  RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 20021101

• P2X purinergic receptor antagonist accelerates skin barrier repair and prevents epidermal hyperplasia induced by skin barrier disruption.

  The Journal of investigative dermatology 20021101

• ATP-evoked calcium responses of radial glial (Müller) cells in the postnatal rabbit retina.

  Journal of neuroscience research 20021015

• Different unfolding pathways for mesophilic and thermophilic homologues of serine hydroxymethyltransferase.

  Biochemistry 20021008

• [MnDPDP--contrast medium with protective effect in acute myocardial infarction].

  Lakartidningen 20021003

• Comparative responses to alpha,beta-methylene-ATP in cat pulmonary, mesenteric, and hindquarter vascular beds.

  Journal of applied physiology (Bethesda, Md. : 1985) 20021001

• Multistate binding in pyridoxine 5'-phosphate synthase: 1.96 A crystal structure in complex with 1-deoxy-D-xylulose phosphate.

  Biochemistry 20021001

• Role for P2X receptors in long-term potentiation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20021001

• Bacterial cysteine desulfurases: their function and mechanisms.

  Applied microbiology and biotechnology 20021001

• Contribution of Lys276 to the conformational flexibility of the active site of glutamate decarboxylase from Escherichia coli.

  European journal of biochemistry 20021001

• Design of pyridoxal 5'-phosphate dependent catalytic antibodies.

  Biochemistry. Biokhimiia 20021001

• Pyridoxal 5'-phosphate as a catalytic and conformational cofactor of muscle glycogen phosphorylase B.

  Biochemistry. Biokhimiia 20021001

• Alexander Evseevich Braunstein.

  Biochemistry. Biokhimiia 20021001

• Pyridoxine sometimes fails to be activated to pyridoxal phosphate.

  Brain research bulletin 20020930

• Structural insight into gene duplication, gene fusion and domain swapping in the evolution of PLP-independent amino acid racemases.

  FEBS letters 20020925

• A possible dual site of action for carbon monoxide-mediated chemoexcitation in the rat carotid body.

  The Journal of physiology 20020915

• Sensory afferent selective role of P2 receptors in the nucleus tractus solitarii for mediating the cardiac component of the peripheral chemoreceptor reflex in rats.

  The Journal of physiology 20020915

• alpha,beta-Methylene ATP elicits a reflex pressor response arising from muscle in decerebrate cats.

  Journal of applied physiology (Bethesda, Md. : 1985) 20020901

• Diagnosis and staging of pancreatic cancer: comparison of mangafodipir trisodium-enhanced MR imaging and contrast-enhanced helical hydro-CT.

  AJR. American journal of roentgenology 20020901

• Preoperative detection of hepatocellular carcinoma: ferumoxides-enhanced versus mangafodipir trisodium-enhanced MR imaging.

  AJR. American journal of roentgenology 20020901

• Homogeneous, nonradioactive, enzymatic assay for plasma pyridoxal 5-phosphate.

  Clinical chemistry 20020901

• Homocysteine, nutritional status and insulin in renal transplant recipients.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20020901

• Cloning and characterization of Arabidopsis thaliana pyridoxal kinase.

  Planta 20020901

• Efficacy of a complex multivitamin supplement.

  Nutrition (Burbank, Los Angeles County, Calif.) 20020901

• Potentiation of inhibitory glycinergic neurotransmission by Zn2+: a synergistic interplay between presynaptic P2X2 and postsynaptic glycine receptors.

  The European journal of neuroscience 20020901

• Role of exocrine cells in pancreatic enhancement using Mn-DPDP-enhanced MR imaging.

  Chinese medical journal 20020901

• Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis.

  Journal of molecular biology 20020823

• Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme.

  Biochemistry 20020820

• Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism.

  Biochemical pharmacology 20020815

• Enzymatic characterization of a recombinant isoform hybrid of glutamic acid decarboxylase (rGAD67/65) expressed in yeast.

  Journal of biotechnology 20020807

• Using contrast-enhanced MR cholangiography with IV mangafodipir trisodium (Teslascan) to evaluate bile duct leaks after cholecystectomy: a prospective study of 11 patients.

  AJR. American journal of roentgenology 20020801

• ATP induces leukemia inhibitory factor mRNA in cultured rat astrocytes.

  Journal of neuroimmunology 20020801

• Kinetic characterization of hypophosphatasia mutations with physiological substrates.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20020801

• Liver lesion detection and characterization with sequential use of hepatobiliary contrast agent mangafodipir trisodium and gadolinium-DTPA in a single imaging protocol.

  Academic radiology 20020801

• Exploring multifunctional features of necrosis avid contrast agents.

  Academic radiology 20020801

• Hydrogen sulfide as a neuromodulator.

  Molecular neurobiology 20020801

• Entamoeba histolytica: purification and characterization of ornithine decarboxylase.

  Experimental parasitology 20020801

• Biotin synthase is a pyridoxal phosphate-dependent cysteine desulfurase.

  Biochemistry 20020723

• Spectroscopic and kinetic analyses reveal the pyridoxal 5'-phosphate binding mode and the catalytic features of Treponema denticola cystalysin.

  Biochemistry 20020723

• Identification of a novel pyridoxal 5'-phosphate binding site in adenosylcobalamin-dependent lysine 5,6-aminomutase from Porphyromonas gingivalis.

  Biochemistry 20020709

• [MR imaging of pancreatic lesions with Mn-DPDP. A histopathologic correlation].

  RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 20020701

• Suramin-induced reversal of chronic cerebral vasospasm in experimental subarachnoid hemorrhage.

  Journal of neurosurgery 20020701

• Evidence of poor vitamin status in coeliac patients on a gluten-free diet for 10 years.

  Alimentary pharmacology & therapeutics 20020701

• Affinity labeling of the guanine nucleotide binding site of transducin by pyridoxal 5'-phosphate.

  Journal of protein chemistry 20020701

• ATP as a putative sensory mediator: activation of intrinsic sensory neurons of the myenteric plexus via P2X receptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20020615

• Vitamin B6 protects primate retinal neurons from ischemic injury.

  Brain research 20020614

• Development of contrast-enhanced virtual MR cholangioscopy: a feasibility study.

  European radiology 20020601

• Crystal structure of aspartate racemase from Pyrococcus horikoshii OT3 and its implications for molecular mechanism of PLP-independent racemization.

  Journal of molecular biology 20020531

• Homocysteine, vitamin B6, and vascular disease in AD patients.

  Neurology 20020528

• Activation of ATP receptor increases the cytosolic Ca(2+) concentration in ventral tegmental area neurons of rat brain.

  Brain research 20020510

• Modulation of phrenic motoneuron excitability by ATP: consequences for respiratory-related output in vitro.

  Journal of applied physiology (Bethesda, Md. : 1985) 20020501

• Threonine-124 and phenylalanine-448 in Citrobacter freundii tyrosine phenol-lyase are necessary for activity with L-tyrosine.

  The Biochemical journal 20020501

• Structure of external aldimine of Escherichia coli CsdB, an IscS/NifS homolog: implications for its specificity toward selenocysteine.

  Journal of biochemistry 20020501

• Spike-independent release of ATP from Xenopus spinal neurons evoked by activation of glutamate receptors.

  The Journal of physiology 20020501

• Characterization of liver lesions with mangafodipir trisodium-enhanced MR imaging: multicenter study comparing MR and dual-phase spiral CT.

  Radiology 20020501

• Liver lesions: manganese-enhanced MR and dual-phase helical CT for preoperative detection and characterization comparison with receiver operating characteristic analysis.

  Radiology 20020501

• Vitamin B6 intakes and status of mechanically ventilated critically ill patients in Taiwan.

  European journal of clinical nutrition 20020501

• Thallium-like test for myocardial viability with MnDPDP-enhanced MRI.

  Academic radiology 20020501

• Effects of heme ligand mutations including a pathogenic variant, H65R, on the properties of human cystathionine beta-synthase.

  Biochemistry 20020409

• Reversible impairment of endothelium-dependent relaxation in golden hamster carotid arteries during hibernation.

  The Journal of physiology 20020401

• Involvement of purinergic signalling in central mechanisms of body temperature regulation in rats.

  British journal of pharmacology 20020401

• Unfolding of pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase probed by time-resolved tryptophan fluorescence.

  Biochimica et biophysica acta 20020401

• Purification and biochemical characterization of some of the properties of recombinant human kynureninase.

  European journal of biochemistry 20020401

• Gas chromatography-mass spectrometry analysis of 4-O-methylpyridoxine (MPN) in the serum of patients with ginkgo seed poisoning.

  Journal of analytical toxicology 20020401

• The PEVKEK region of the pyridoxal phosphate binding domain of GAD65 expresses a dominant B cell epitope for type 1 diabetes sera.

  Annals of the New York Academy of Sciences 20020401

• Characteristics of ATP-induced current through P2X7 receptor in NG108-15 cells: unique antagonist sensitivity and lack of pore formation.

  Japanese journal of pharmacology 20020401

• Multimodality diagnosis of liver tumors: feature analysis with CT, liver-specific and contrast-enhanced MR, and a computer model.

  Academic radiology 20020301

• Kinetics of antagonist actions at rat P2X2/3 heteromeric receptors.

  British journal of pharmacology 20020301

• The Arabidopsis salt overly sensitive 4 mutants uncover a critical role for vitamin B6 in plant salt tolerance.

  The Plant cell 20020301

• TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics.

  Pain 20020301

• Stability and transmetallation of the magnetic resonance contrast agent MnDPDP measured by EPR.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20020301

• Cysteine synthase of an extremely thermophilic bacterium, Thermus thermophilus HB8.

  Bioscience, biotechnology, and biochemistry 20020301

• Modification of an essential amino group in the mineralocorticoid receptor evidences a differential conformational change of the receptor protein upon binding of antagonists, natural agonists and the synthetic agonist 11,19-oxidoprogesterone.

  Biochimica et biophysica acta 20020213

• Yeast cystathionine beta-synthase reacts with L-allothreonine, a non-natural substrate, and L-homocysteine to form a new amino acid, 3-methyl-L-cystathionine.

  Biochemistry 20020212

• Cold-induced enzyme inactivation: how does cooling lead to pyridoxal phosphate-aldimine bond cleavage in tryptophanase?

  Biochimica et biophysica acta 20020211

• Functional attributes of the phosphate group binding cup of pyridoxal phosphate-dependent enzymes.

  Journal of molecular biology 20020208

• Pharmacological characterization of the P2X(7) receptor on human macrophages using the patch-clamp technique.

  Naunyn-Schmiedeberg's archives of pharmacology 20020201

• Ginkgo seed poisoning.

  Pediatrics 20020201

• Multifocal inflammatory pseudotumor of the liver: dynamic gadolinium-enhanced, ferumoxides-enhanced, and mangafodipir trisodium-enhanced MR imaging findings.

  European radiology 20020201

• Pyridoxal phosphate-responsive epilepsy with resistance to pyridoxine.

  Pediatric neurology 20020201

• ATP induces proliferation of retinal cells in culture via activation of PKC and extracellular signal-regulated kinase cascade.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20020201

• Vitamin B6 status of breast-fed infants in relation to pyridoxine HCl supplementation of mothers.

  Journal of nutritional science and vitaminology 20020201

• Chemical modification of specific active site amino acid residues of Enterobacter aerogenes glycerol dehydrogenase.

  Journal of enzyme inhibition and medicinal chemistry 20020201

• Active site structure and stereospecificity of Escherichia coli pyridoxine-5'-phosphate oxidase.

  Journal of molecular biology 20020118

• Inhibition of camel lens zeta-crystallin by aspirin and aspirin-like analgesics.

  The international journal of biochemistry & cell biology 20020101

• Regulation of transcervical permeability by two distinct P2 purinergic receptor mechanisms.

  American journal of physiology. Cell physiology 20020101

• Cyclic adenosine monophosphate-dependent vascular responses to purinergic agonists adenosine triphosphate and uridine triphosphate in the anesthetized mouse.

  Journal of cardiovascular pharmacology 20020101

• Vitamin B6 metabolism and homocysteine in end-stage renal disease and chronic renal insufficiency.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20020101

• Functioning acinar cell pancreatic carcinoma: diagnosis on mangafodipir trisodium (Mn-DPDP)-enhanced MRI.

  Journal of computer assisted tomography 20020101

• Reduced serum concentrations of riboflavine and ascorbic acid, and blood thiamine pyrophosphate and pyridoxal-5-phosphate in geriatric patients with and without pressure sores.

  The journal of nutrition, health & aging 20020101

• MRI characteristics in focal hepatic disease before and after administration of MnDPDP: discriminant analysis as a diagnostic tool.

  European radiology 20020101

• Selenium status and its correlates in a British national diet and nutrition survey: people aged 65 years and over.

  Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20020101

• Contrast-enhanced MRI of the liver with mangafodipir trisodium: imaging technique and results.

  Journal of computer assisted tomography 20020101

• Homocysteine, vitamin B(6), and lipid in cardiovascular disease.

  Nutrition (Burbank, Los Angeles County, Calif.) 20020101

• Cooperativity between extracellular adenosine 5'-triphosphate and activation of N-methyl-D-aspartate receptors in long-term potentiation induction in hippocampal CA1 neurons.

  Neuroscience 20020101

• A case of primary Sjögren's syndrome associated with low titer cold agglutinin disease.

  Clinical and experimental rheumatology 20020101

• Vitamin B6 status of children with sickle cell disease.

  Journal of pediatric hematology/oncology 20020101

• Pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) as a tool for differentiation of P2Y2-receptor-mediated vasorelaxation in guinea pig aorta.

  Methods and findings in experimental and clinical pharmacology 20020101

• Structure-activity relationships of suramin and pyridoxal-5'-phosphate derivatives as P2 receptor antagonists.

  Current pharmaceutical design 20020101

• Detection of intermediates in reactions catalyzed by PLP-dependent enzymes: O-acetylserine sulfhydrylase and serine-glyoxalate aminotransferase.

  Methods in enzymology 20020101

• [Organ specific MRI contrast media in general practice].

  Wiener medizinische Wochenschrift. Supplement 20020101

• Pyridoxal 5'-phosphate inhibits DNA binding of HNF1.

  Biochimica et biophysica acta 20011219

• Extracellular nucleotides regulate cellular functions of podocytes in culture.

  American journal of physiology. Renal physiology 20011201

• Identification of a critical lysine residue at the active site in glyceraldehyde-3-phosphate dehydrogenase of Ehrlich ascites carcinoma cell. Comparison with the rabbit muscle enzyme.

  European journal of biochemistry 20011201

• l-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subgroup of strictly related enzymes specialized for different functions.

  European journal of biochemistry 20011201

• ATP-induced histamine release is in part related to phospholipase A2-mediated arachidonic acid metabolism in rat peritoneal mast cells.

  Archives of pharmacal research 20011201

• Rapid correction of vestibular imbalance by intracochlear administration of ATP in a guinea pig model of unilateral peripheral vestibular disorder.

  Neuroscience letters 20011123

• Distribution of B6 vitamers in Escherichia coli as determined by enzymatic assay.

  Analytical biochemistry 20011115

• Pyridoxal 5'-phosphate and pyridoxal inhibit angiogenesis in serum-free rat aortic ring assay.

  International journal of molecular medicine 20011101

• Contrast-enhanced magnetic resonance cholangiography versus heavily T2-weighted magnetic resonance cholangiography.

  Investigative radiology 20011101

• Structure-activity relationships of diadenosine polyphosphates (Ap(n)As), adenosine polyphospho guanosines (Ap(n)Gs) and guanosine polyphospho guanosines (Gp(n)Gs) at P2 receptors in the rat mesenteric arterial bed.

  British journal of pharmacology 20011101

• Proteinuria and plasma total homocysteine levels in chronic renal disease patients with a normal range serum creatinine: critical impact of true glomerular filtration rate.

  Atherosclerosis 20011101

• New contrast agents for imaging the liver.

  Magnetic resonance imaging clinics of North America 20011101

• P2 receptor-types involved in astrogliosis in vivo.

  British journal of pharmacology 20011101

• Characterization of the prostanoid receptor types involved in mediating calcitonin gene-related peptide release from cultured rat trigeminal neurones.

  British journal of pharmacology 20011101

• Contrast-enhanced MR imaging in the diagnosis and preservation of cardiac viability.

  Acta radiologica (Stockholm, Sweden : 1987) 20011101

• Cardioprotective effects of the MR contrast agent MnDPDP and its metabolite MnPLED upon reperfusion of the ischemic porcine myocardium.

  Acta radiologica (Stockholm, Sweden : 1987) 20011101

• [Aspartate aminotransferase (glutamic oxalacetic transaminase) and alanine aminotransferase (glutamic pyruvic transaminase)].

  Rinsho byori. The Japanese journal of clinical pathology 20011101

• Developmental changes in P2X purinoceptors on glycinergic presynaptic nerve terminals projecting to rat substantia gelatinosa neurones.

  The Journal of physiology 20011015

• Crystal structures of 1-aminocyclopropane-1-carboxylate (ACC) synthase in complex with aminoethoxyvinylglycine and pyridoxal-5'-phosphate provide new insight into catalytic mechanisms.

  The Journal of biological chemistry 20011012

• Differential responses to ATPgammaS in the mesenteric and hindlimb vascular bed of the cat.

  Life sciences 20011012

• COMT genotype, micronutrients in the folate metabolic pathway and breast cancer risk.

  Carcinogenesis 20011001

• Seizures induced by intracerebral administration of pyridoxal-5'-phosphate: effect of GABAergic drugs and glutamate receptor antagonists.

  Neuropharmacology 20011001

• The biosynthesis of ovothiol A (N-methyl-4-mercaptohistidine). Identification of S-(4'-L-histidyl)-L-cysteine sulfoxide as an intermediate and the products of the sulfoxide lyase reaction.

  European journal of biochemistry 20011001

• The content of glycogen phosphorylase and glycogen in preparations of sarcoplasmic reticulum-glycogenolytic complex is enhanced in diabetic rat skeletal muscle.

  Diabetologia 20011001

• Plants synthesize ethanolamine by direct decarboxylation of serine using a pyridoxal phosphate enzyme.

  The Journal of biological chemistry 20010921

• Smooth muscle does not have a common P2x receptor phenotype: expression, ontogeny and function of P2x1 receptors in mouse ileum, bladder and reproductive systems.

  Autonomic neuroscience : basic & clinical 20010917

• Properties and interaction of heterologously expressed glutamate decarboxylase isoenzymes GAD(65kDa) and GAD(67kDa) from human brain with ginkgotoxin and its 5'-phosphate.

  Journal of medicinal chemistry 20010913

• ATP P2X receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20010901

• P2Y(AC)(-)-receptor agonists enhance the proliferation of rat C6 glioma cells through activation of the p42/44 mitogen-activated protein kinase.

  British journal of pharmacology 20010901

• Independent receptors for diadenosine pentaphosphate and ATP in rat midbrain single synaptic terminals.

  The European journal of neuroscience 20010901

• [Magnetic resonance imaging of the liver: what kind of contrast agents?].

  La Radiologia medica 20010901

• Crystal structure of histidinol phosphate aminotransferase (HisC) from Escherichia coli, and its covalent complex with pyridoxal-5'-phosphate and l-histidinol phosphate.

  Journal of molecular biology 20010824

• P2X3 knock-out mice reveal a major sensory role for urothelially released ATP.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20010801

• Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein.

  The EMBO journal 20010801

• Clinical and cost effectiveness of a new hepatocellular MRI contrast agent, mangafodipir trisodium, in the preoperative assessment of liver resectability.

  Annals of surgical oncology 20010801

• Production of pyridoxal phosphate by a mutant strain of Schizosaccharomyces pombe.

  Bioscience, biotechnology, and biochemistry 20010801

• PLP and PMP radicals: a new paradigm in coenzyme B6 chemistry.

  Bioorganic chemistry 20010801

• X-ray structure of Escherichia coli pyridoxine 5'-phosphate oxidase complexed with pyridoxal 5'-phosphate at 2.0 A resolution.

  Journal of molecular biology 20010720

• Influence of pyridoxal 5'-phosphate alone and in combination with vigabatrin on brain GABA measured by 1H-NMR-spectroscopy.

  Brain research bulletin 20010701

• Nucleotide-evoked relaxation of rat vas deferens--a possible role for endogenous ATP released upon alpha(1)-adrenoceptor stimulation.

  European journal of pharmacology 20010622

• Role of endogenous ATP at the incision area in a rat model of postoperative pain.

  Neuroreport 20010613

• Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels.

  Circulation 20010612

• Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme.

  The Journal of biological chemistry 20010601

• ATP affects both axons and Schwann cells of unmyelinated C fibres.

  Pain 20010601

• Dephosphorylation of MnDPDP and related compounds by acid and alkaline phosphatase.

  Journal of pharmaceutical and biomedical analysis 20010601

• PPADS, an ATP antagonist, attenuates the effects of a moderately intense sound on cochlear mechanics.

  Hearing research 20010601

• Sensitivity to meat protein intake and hyperoxaluria in idiopathic calcium stone formers.

  Kidney international 20010601

• Cassette mutagenesis of lysine 130 of human glutamate dehydrogenase. An essential residue in catalysis.

  European journal of biochemistry 20010601

• Stimulation of P2 receptors in the ventral tegmental area enhances dopaminergic mechanisms in vivo.

  Neuropharmacology 20010601

• Effect of feeding on circulating micronutrient concentrations in the Burmese python (Python molurus).

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20010601

• Effect of vitamin B6 deficiency on the synthesis and accumulation of S-adenosylhomocysteine and S-adenosylmethionine in rat tissues.

  Journal of nutritional science and vitaminology 20010601

• Accelerated functional recovery after neuronal injury by P2 receptor blockade.

  European journal of pharmacology 20010525

• Pyridoxal phosphate de-activation by pyrroline-5-carboxylic acid. Increased risk of vitamin B6 deficiency and seizures in hyperprolinemia type II.

  The Journal of biological chemistry 20010504

• Molecular cloning and functional expression of Xenopus laevis oocyte ATP-activated P2X4 channels.

  Biochimica et biophysica acta 20010502

• Three-dimensional structure of 2-amino-3-ketobutyrate CoA ligase from Escherichia coli complexed with a PLP-substrate intermediate: inferred reaction mechanism.

  Biochemistry 20010501

• Intracellular signaling pathways involved in acetaldehyde-induced collagen and fibronectin gene expression in human hepatic stellate cells.

  Hepatology (Baltimore, Md.) 20010501

• Volumetric mangafodipir trisodium-enhanced cholangiography to define intrahepatic biliary anatomy.

  AJR. American journal of roentgenology 20010401

• Determination of mangafodipir trisodium and related impurities in bulk substance and pharmaceutical formulation by ion-pair high-performance liquid chromatography.

  Journal of pharmaceutical and biomedical analysis 20010401

• Renal microvascular effects of P2 receptor stimulation.

  Clinical and experimental pharmacology & physiology 20010401

• The positive inotropic and chronotropic effects of evodiamine and rutaecarpine, indoloquinazoline alkaloids isolated from the fruits of Evodia rutaecarpa, on the guinea-pig isolated right atria: possible involvement of vanilloid receptors.

  Planta medica 20010401

• Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor.

  European journal of pharmacology 20010330

• Structural basis for the function of pyridoxine 5'-phosphate synthase.

  Structure (London, England : 1993) 20010307

• Complexities of measuring antagonist potency at P2X(7) receptor orthologs.

  The Journal of pharmacology and experimental therapeutics 20010301

• Enhancement of ATP release in hindlimb sympathetic perivascular nerve of the golden hamster during hibernation.

  The Journal of physiology 20010301

• Resuscitation with a blood substitute abrogates pathologic postinjury neutrophil cytotoxic function.

  The Journal of trauma 20010301

• Characterisation of P2Y(1)-like receptor in cultured rat pineal glands.

  European journal of pharmacology 20010301

• [Comparison of biphasic spiral CT and MnDPDP-enhanced MRI in the detection and characterization of liver lesions].

  RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 20010301

• Effect of phosphate on stability of pyridoxal in the presence of lysine.

  Journal of agricultural and food chemistry 20010301

• A placebo-controlled, double-blind, randomised trial of magnesium-pyridoxal-5'-phosphate-glutamate for hypercholesterolaemia and other clinical-chemical risk factors of cardiovascular disease in a primary care setting.

  European journal of clinical pharmacology 20010301

• Crystal structure of threonine synthase from Arabidopsis thaliana.

  Protein science : a publication of the Protein Society 20010301

• Clinical adaptation of a high-performance liquid chromatographic method for the assay of pyridoxal 5'-phosphate in human plasma.

  Journal of chromatography. B, Biomedical sciences and applications 20010225

• Occurrence of D-Amino Acids and a pyridoxal 5'-phosphate-dependent aspartate racemase in the acidothermophilic archaeon, Thermoplasma acidophilum.

  Biochemical and biophysical research communications 20010223

• Inhibitors of advanced glycation end product-associated protein cross-linking.

  Biochimica et biophysica acta 20010214

• Rapid kinetic and isotopic studies on dialkylglycine decarboxylase.

  Biochemistry 20010206

• Computational studies on nonenzymatic and enzymatic pyridoxal phosphate catalyzed decarboxylations of 2-aminoisobutyrate.

  Biochemistry 20010206

• Brain succinic semialdehyde dehydrogenase: identification of reactive lysyl residues labeled with pyridoxal-5'-phosphate.

  Journal of neurochemistry 20010201

• Distinct modulation of evoked and spontaneous EPSCs by purinoceptors in the nucleus tractus solitarii of the rat.

  The Journal of physiology 20010201

• Analysis of purine- and pyrimidine-induced vascular responses in the isolated rat cerebral arteriole.

  American journal of physiology. Heart and circulatory physiology 20010201

• Mechanism of prolonged vasorelaxation to ATP in the rat isolated mesenteric arterial bed.

  British journal of pharmacology 20010201

• Do ATP and UTP involve cGMP in positive inotropism on rat atria?

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20010201

• Inhibitory effect of glycation on catalytic activity of alanine aminotransferase.

  Molecular and cellular biochemistry 20010201

• Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors.

  Journal of medicinal chemistry 20010201

• Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding.

  FEBS letters 20010119

• Metal ion inhibition of nonenzymatic pyridoxal phosphate catalyzed decarboxylation and transamination.

  Journal of the American Chemical Society 20010117

• Strain is more important than electrostatic interaction in controlling the pKa of the catalytic group in aspartate aminotransferase.

  Biochemistry 20010116

• Resonance Raman characterization of the heme cofactor in cystathionine beta-synthase. Identification of the Fe-S(Cys) vibration in the six-coordinate low-spin heme.

  Biochemistry 20010116

• Identification of lysine 346 as a functionally important residue for pyridoxal 5'-phosphate binding and catalysis in lysine 2, 3-aminomutase from Bacillus subtilis.

  Biochemistry 20010116

• The role of pyridoxal phosphate in the function of EspB, a protein secreted by enteropathogenic Escherichia coli.

  FEBS letters 20010112

• Functional properties of the active core of human cystathionine beta-synthase crystals.

  The Journal of biological chemistry 20010105

• Frequency dependent alpha(2)-adrenoceptor mediated modulation of excitatory junction potentials in guinea-pig mesenteric artery.

  European journal of pharmacology 20010105

• Properties of native P2X receptors in rat trigeminal mesencephalic nucleus neurones: lack of correlation with known, heterologously expressed P2X receptors.

  Neuropharmacology 20010101

• The anesthetic interaction between adenosine triphosphate and N-methyl-D-aspartate receptor antagonists in the rat.

  Anesthesia and analgesia 20010101

• Multiple P2X receptors on guinea-pig pelvic ganglion neurons exhibit novel pharmacological properties.

  British journal of pharmacology 20010101

• Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells.

  British journal of pharmacology 20010101

• Technical report: lymph node enhancement at MRI with MnDPDP in primary hepatic carcinoma.

  Clinical radiology 20010101

• The purinergic P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2'4'-disulphonic acid prevents both the acute locomotor effects of amphetamine and the behavioural sensitization caused by repeated amphetamine injections in rats.

  Neuroscience 20010101

• The value of MnDPDP enhancement during MR guided laser interstitial thermoablation of liver tumors.

  Journal of magnetic resonance imaging : JMRI 20010101

• Pyridoxal 5'-phosphate-dependent alpha,beta-elimination reactions: mechanism of O-acetylserine sulfhydrylase.

  Accounts of chemical research 20010101

• Determination of vitamin B(6) in cooked sausages.

  Journal of agricultural and food chemistry 20010101

• Detection of bile duct leaks using MR cholangiography with mangfodipir trisodium (Teslascan).

  Journal of computer assisted tomography 20010101

• Phylogenetic analyses and comparative genomics of vitamin B6 (pyridoxine) and pyridoxal phosphate biosynthesis pathways.

  Journal of molecular microbiology and biotechnology 20010101

• Inhibition of the NANC relaxation of the guinea-pig proximal colon longitudinal muscle by the purinoceptor antagonist PPADS, inhibition of nitric oxide synthase, but not by a PACAP/VIP antagonist.

  Pharmacological research 20010101

• Co-transmitter function of ATP in central catecholaminergic neurons of the rat.

  Neuroscience 20010101

• Effects of long-term parenteral administration of vitamin B6 on B6 status and some aspects of the glucose and protein metabolism of early-weaned piglets.

  The British journal of nutrition 20010101

• Characterization of prejunctional purinoceptors inhibiting noradrenaline release in rat mesenteric arteries.

  Japanese journal of pharmacology 20010101

• Identification and characterization of an aromatic amino acid decarboxylase from the filarial nematode, Dirofilaria immitis.

  Biological chemistry 20010101

• Testing the tyrosine/catecholamine hypothesis of oral contraceptive-induced psychological side-effects: a controlled study on triphasil.

  Annals of nutrition & metabolism 20010101

• Correlation of MRI and CT findings with histopathology in hepatic angiomyolipoma.

  European radiology 20010101

• [Temperature-dependent contractions of the guinea pig vas deferens mediated by P2X receptors].

  Eksperimental'naia i klinicheskaia farmakologiia 20010101

• Excitatory effect of ATP on acutely dissociated ventromedial hypothalamic neurons of the rat.

  Neuroscience 20010101

• Effects of diallyl disulfide and other donors of sulfane sulfur on the proliferation of human hepatoma cell line (HepG2).

  Neoplasma 20010101

• Plasma folate but not vitamin B(12) or homocysteine concentrations are reduced after short-term vitamin B(6) supplementation.

  Annals of nutrition & metabolism 20010101

• Neuroprotective effects of pyridoxal phosphate and pyridoxal against ischemia in monkeys.

  Nutritional neuroscience 20010101

• Tryptophan synthase: a multienzyme complex with an intramolecular tunnel.

  Chemical record (New York, N.Y.) 20010101

• The role of radicals in enzymatic processes.

  Chemical record (New York, N.Y.) 20010101

• Stereospecificity for the hydrogen transfer of pyridoxal enzyme reactions.

  Chemical record (New York, N.Y.) 20010101

• From cofactor to enzymes. The molecular evolution of pyridoxal-5'-phosphate-dependent enzymes.

  Chemical record (New York, N.Y.) 20010101

• Purinergic and adrenergic agonists synergize in stimulating vasopressin and oxytocin release.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20001201

• Safety and efficacy of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: results of the U.S. multicenter phase III clinical trials (safety).

  Journal of magnetic resonance imaging : JMRI 20000701

• Pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS), a putative P2Y(1) receptor antagonist, blocks signaling at a site distal to the receptor in Madin-Darby canine kidney-D(1) cells.

  The Journal of pharmacology and experimental therapeutics 20000101

• Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice.

  British journal of pharmacology 19991201

• Mechanisms of action of liver contrast agents: impact for clinical use.

  Journal of computer assisted tomography 19991101

• Seizures induced by theophylline and isoniazid in mice.

  Veterinary and human toxicology 19990601

• A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonize activation of P2X1 receptors.

  Journal of medicinal chemistry 19980618

• Mangafodipir trisodium (MnDPDP)-enhanced magnetic resonance imaging of the liver and pancreas.

  Acta radiologica. Supplementum 19980101

• Dynamic evaluation of the hepatic uptake and clearance of manganese-based MRI contrast agents: a 31P NMR study on the isolated and perfused rat liver.

  Journal of magnetic resonance imaging : JMRI 19980101

• Metabolism and pharmacokinetics of MnDPDP in man.

  Acta radiologica (Stockholm, Sweden : 1987) 19970701

• Plasma pharmacokinetics, tissue distribution and excretion of MnDPDP in the rat and dog after intravenous administration.

  Acta radiologica (Stockholm, Sweden : 1987) 19970701

• Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6.

  Nature genetics 19950901

• Pyridoxine as therapy in theophylline-induced seizures.

  Veterinary and human toxicology 19950801

• Biochemical characterization of gapB-encoded erythrose 4-phosphate dehydrogenase of Escherichia coli K-12 and its possible role in pyridoxal 5'-phosphate biosynthesis.

  Journal of bacteriology 19950501

• In vivo modification of GABAA receptor with a high dose of pyridoxal phosphate induces tonic-clonic convulsion in immature mice.

  Neurochemistry international 19950401

• Mammalian DNA ligase II is highly homologous with vaccinia DNA ligase. Identification of the DNA ligase II active site for enzyme-adenylate formation.

  The Journal of biological chemistry 19941216

• Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate.

  Antimicrobial agents and chemotherapy 19941001

• Vitamin B-6 supplementation and theophylline-related effects in humans.

  The American journal of clinical nutrition 19940701

• Isolation and expression of a cDNA coding for rat kidney cytosolic cysteine conjugate beta-lyase.

  Molecular pharmacology 19930501

• Chemical modification of bacteriophage T4 deoxynucleotide kinase. Evidence of a single catalytic region.

  The Journal of biological chemistry 19930125

• Pyridoxal-5'-phosphate inhibits the polymerase activity of a recombinant RNAase H-deficient mutant of HIV-1 reverse transcriptase.

  AIDS research and human retroviruses 19920501

• Isoniazid inhibition of mycolic acid synthesis by cell extracts of sensitive and resistant strains of Mycobacterium aurum.

  Antimicrobial agents and chemotherapy 19910601

• Inhibition of human brain aromatic L-amino acid decarboxylase by cooked food-derived 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and other heterocyclic amines.

  Neuroscience letters 19900824

• Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects (8): Protective effect of pyridoxal-5'-phosphate against tobramycin nephrotoxicity.

  Japanese journal of pharmacology 19900101

• Pig gastric (H+ + K+)-ATPase. Lys-497 conserved in cation transporting ATPases is modified with pyridoxal 5'-phosphate.

  The Journal of biological chemistry 19890525

• Identification of a lysyl residue in antithrombin which is essential for heparin binding.

  The Journal of biological chemistry 19870615

• Purification and properties of the aromatic amino acid aminotransferase from gramicidin S-producing Bacillus brevis.

  Journal of biochemistry 19870401

• Effect of L-tryptophan excess and vitamin B6 deficiency on rat urinary bladder cancer promotion.

  Cancer research 19870301

• Effect of modification of lysine residues of fructose-6-phosphate 2-kinase:fructose-2,6-bisphosphatase with pyridoxal 5'-phosphate.

  The Journal of biological chemistry 19851115

• Modification of the vitamin K-dependent carboxylase assay.

  Journal of biochemical and biophysical methods 19850501

• Covalent modification of the solubilized rat liver vitamin K-dependent carboxylase with pyridoxal-5'-phosphate.

  Archives of biochemistry and biophysics 19841201

• The effect of pyridoxal phosphate-induced convulsive seizures on rat brain phospholipid metabolism.

  Italian journal of neurological sciences 19840601

• Vitamin K-dependent carboxylase. Partial purification and properties of the enzyme-substrate complex.

  The Journal of biological chemistry 19821225

• Effect of pyridoxal phosphate deficiency on aromatic L-amino acid decarboxylase activity with L-DOPA and L-5-hydroxytryptophan as substrates in rats.

  Japanese journal of pharmacology 19821001

• Mechanistic studies on the pyridoxal phosphate enzyme 1-aminocyclopropane-1-carboxylate deaminase from Pseudomonas sp.

  Biochemistry 19811222

• Anticonvulsant activity of muscimol and gamma-aminobutyric acid against pyridoxal phosphate-induced epileptic seizures.

  Journal of neurochemistry 19810101

• Arginine decarboxylase from a Pseudomonas species.

  Journal of bacteriology 19760201

• Arginine decarboxylase from Lathyrus sativus seedlings. Purification and properites.

  European journal of biochemistry 19751115

• [Effect of pH and pyridoxal phosphate on the quaternary structure of E. coli glutamate decarboxylase].

  Doklady Akademii nauk SSSR 19751111

• S-adenosylmethionine decarboxylase from baker's yeast.

  The Biochemical journal 19751001

• Seizure susceptibility in the developing mouse and its relationship to glutamate decarboxylase and pyridoxal phosphate in brain.

  Journal of neurobiology 19750301

• Purification and characterization of glutamate decarboxylase from mouse brain.

  The Journal of biological chemistry 19730510

• Biosynthesis of biotin: synthesis of 7,8-diaminopelargonic acid in cell-free extracts of Escherichia coli.

  Journal of bacteriology 19710301

• Polarographic identification of the reactive form in the hydrolysis of pyridoxal 5-phosphate.

  Biochimica et biophysica acta 19601104