421581-70-6 | 5-(4-Fluorophenyl)-3-(3-nitrophenyl)-1,2,4-oxadiazole

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$26.00	$18.00
5g	97%	in stock	$50.00	$35.00
25g	97%	in stock	$139.00	$97.00
100g	97%	in stock	$387.00	$271.00

Description

• Catalog Number: AF60910
• Chemical Name: 5-(4-Fluorophenyl)-3-(3-nitrophenyl)-1,2,4-oxadiazole
• CAS Number: 421581-70-6
• Molecular Formula: C14H8FN3O3
• Molecular Weight: 285.2300
• MDL Number: MFCD03142768
• SMILES: Fc1ccc(cc1)c1onc(n1)c1cccc(c1)[N+](=O)[O-]

Computed Properties

• Complexity: 371
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• XLogP3: 3.4

Literature

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  Chemical & pharmaceutical bulletin 20110101

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  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20110101

• Synthesis and structure of azole-fused indeno[2,1-c]quinolines and their anti-mycobacterial properties.

  Organic & biomolecular chemistry 20101221

• Chain length effect on the binding of amphiphiles to serum albumin and to POPC bilayers.

  The journal of physical chemistry. B 20101216

• Green synthesis and biological evaluation of some novel azoles as antimicrobial agents.

  Bioorganic & medicinal chemistry letters 20101215

• Cu-catalyzed efficient synthetic methodology for ebselen and related Se-N heterocycles.

  Organic letters 20101203

• Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse.

  Diabetes 20101201

• Persistent Candida albicans colonization and molecular mechanisms of azole resistance in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients.

  The Journal of antimicrobial chemotherapy 20101201

• Proteomic analysis of cytosolic proteins associated with petite mutations in Candida glabrata.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20101201

• Antifungal prophylaxis and therapy in patients with hematological malignancies and hematopoietic stem cell transplant recipients.

  Expert review of anti-infective therapy 20101201

• Azole drugs trap cytochrome P450 EryK in alternative conformational states.

  Biochemistry 20101102

• Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B.

  Antimicrobial agents and chemotherapy 20101101

• Environmental study of azole-resistant Aspergillus fumigatus and other aspergilli in Austria, Denmark, and Spain.

  Antimicrobial agents and chemotherapy 20101101

• A rapid and efficient route to benzazole heterocycles.

  Nature protocols 20101101

• Pharmacological considerations for azole antifungal drug management in cystic fibrosis lung transplant patients.

  Medical mycology 20101101

• Synthesis and in vitro anticancer activities of some selenadiazole derivatives.

  Archiv der Pharmazie 20101101

• Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.

  Antimicrobial agents and chemotherapy 20101001

• In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan.

  International journal of antimicrobial agents 20101001

• Azole derivatives as histamine H3 receptor antagonists, part 2: C-C and C-S coupled heterocycles.

  Bioorganic & medicinal chemistry letters 20101001

• Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: azoles: effective metal chelators.

  Bioorganic & medicinal chemistry letters 20101001

• Azole derivatives as histamine H3 receptor antagonists, part I: thiazol-2-yl ethers.

  Bioorganic & medicinal chemistry letters 20101001

• Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009.

  The Journal of antimicrobial chemotherapy 20101001

• Cutaneous phaeohyphomycosis in renal allograft recipients: report of 2 cases and review of the literature.

  Diagnostic microbiology and infectious disease 20101001

• Dynamics within site selectively templated and tagged xerogel sensor platforms.

  Applied spectroscopy 20101001

• Cobalt-catalyzed addition of azoles to alkynes.

  Organic letters 20100917

• Heme oxygenase inhibition by 1-aryl-2-(1h-imidazol-1-yl/1h-1,2,4-triazol-1-yl)ethanones and their derivatives.

  ChemMedChem 20100903

• Interactions between antifungal and antiretroviral agents.

  Expert opinion on drug safety 20100901

• Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice.

  American journal of physiology. Lung cellular and molecular physiology 20100901

• Experimental murine scedosporiosis: histopathology and azole treatment.

  Antimicrobial agents and chemotherapy 20100901

• Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents.

  European journal of medicinal chemistry 20100901

• The serine/threonine protein phosphatase Sit4p activates multidrug resistance in Saccharomyces cerevisiae.

  FEMS yeast research 20100901

• Functional characterization of the PP2C phosphatase CaPtc2p in the human fungal pathogen Candida albicans.

  Yeast (Chichester, England) 20100901

• Reversal of stereoselectivity in the Cu-catalyzed conjugate addition reaction of dialkylzinc to cyclic enone in the presence of a chiral azolium compound.

  The Journal of organic chemistry 20100820

• Synergistic anticandidal activity of pure polyphenol curcumin I in combination with azoles and polyenes generates reactive oxygen species leading to apoptosis.

  FEMS yeast research 20100801

• Azole antimycotics and drug interactions in the perioperative period.

  Current opinion in anaesthesiology 20100801

• Management of drug and food interactions with azole antifungal agents in transplant recipients.

  Pharmacotherapy 20100801

• An enantioselective Claisen rearrangement catalyzed by N-heterocyclic carbenes.

  Journal of the American Chemical Society 20100707

• The antifungal properties of chicken egg cystatin against Candida yeast isolates showing different levels of azole resistance.

  Mycoses 20100701

• Impact of education and an antifungal stewardship program for candidiasis at a Thai tertiary care center.

  Infection control and hospital epidemiology 20100701

• [Advances in the study of Candida albicans gene mutation on azole drug resistance].

  Yao xue xue bao = Acta pharmaceutica Sinica 20100701

• Diphenyl diselenide behaves differently than ebselen under different pH media in rat's liver preparations.

  Pathology, research and practice 20100615

• Azole resistance in allergic bronchopulmonary aspergillosis and Aspergillus bronchitis.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20100601

• Microbiological characteristics of clinical isolates of Cryptococcus neoformans in Taiwan: serotypes, mating types, molecular types, virulence factors, and antifungal susceptibility.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20100601

• Phaeohyphomycosis due to Alternaria species in transplant recipients.

  Transplant infectious disease : an official journal of the Transplantation Society 20100601

• Roles for Nox4 in the contractile response of bovine pulmonary arteries to hypoxia.

  American journal of physiology. Heart and circulatory physiology 20100601

• New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.

  Bioorganic & medicinal chemistry 20100601

• Synthesis of a second generation chroman/catechol hybrids and evaluation of their activity in protecting neuronal cells from oxidative stress-induced cell death.

  Bioorganic & medicinal chemistry 20100601

• In vitro synergistic interactions of the effects of various statins and azoles against some clinically important fungi.

  FEMS microbiology letters 20100601

• Metal-free coupling of azoles with 2- and 3-haloindoles providing access to novel 2- or 3-(azol-1-yl)indole derivatives.

  Organic letters 20100521

• Synthesis and in vitro and in vivo antifungal activity of the hydroxy metabolites of saperconazole.

  ChemMedChem 20100503

• Effects of ebselen versus nimodipine on cerebral vasospasm subsequent to experimental subarachnoid hemorrhage in rats.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20100501

• Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives.

  Bioorganic & medicinal chemistry letters 20100501

• [Therapy of candidemia and invasive candidiasis according to guidelines].

  Mycoses 20100501

• [Guideline based treatment of invasive aspergillosis].

  Mycoses 20100501

• Antifungal drug resistance: not all azoles are equal.

  Expert review of anti-infective therapy 20100501

• Solid phase extraction--multisyringe flow injection system for the spectrophotometric determination of selenium with 2,3-diaminonaphthalene.

  Talanta 20100415

• In vitro investigation of antifungal activity of allicin alone and in combination with azoles against Candida species.

  Mycopathologia 20100401

• Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes.

  Cardiovascular research 20100401

• Molecular aspects of azoles-induced teratogenesis.

  Expert opinion on drug metabolism & toxicology 20100401

• Susceptibility to five antifungals of Aspergillus fumigatus strains isolated from chronically colonised cystic fibrosis patients receiving azole therapy.

  International journal of antimicrobial agents 20100401

• Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes.

  PLoS pathogens 20100401

• Ebselen reduces inflammation and microvascular perfusion failure after blunt skeletal muscle injury of the rat.

  The Journal of trauma 20100401

• Invasive candidiasis in the intensive care unit.

  Hospital practice (1995) 20100401

• Cloud point extraction and electrothermal atomic absorption spectrometry of Se (IV)--3,3'-diaminobenzidine for the estimation of trace amounts of Se (IV) and Se (VI) in environmental water samples and total selenium in animal blood and fish tissue samples.

  Journal of hazardous materials 20100315

• Current concepts in systemic and topical therapy for superficial mycoses.

  Clinics in dermatology 20100304

• Urban pigeons (Columba livia) as a potential source of pathogenic yeasts: a focus on antifungal susceptibility of Cryptococcus strains in Northeast Brazil.

  Mycopathologia 20100301

• Structural characterization of human heme oxygenase-1 in complex with azole-based inhibitors.

  Journal of inorganic biochemistry 20100301

• Improved model of lanosterol 14alpha-demethylase by ligand-supported homology modeling: validation by virtual screening and azole optimization.

  ChemMedChem 20100301

• Prophylactic antifungal agents used after lung transplantation.

  The Annals of pharmacotherapy 20100301

• 5-Selenization of salicylic acid derivatives yielded isoform-specific 5-lipoxygenase inhibitors.

  Organic & biomolecular chemistry 20100221

• Determination of Se(IV) in natural waters by adsorptive stripping voltammetry of 5-nitropiazselenol.

  Journal of hazardous materials 20100215

• Copper-catalyzed annulation of 2-formylazoles with o-aminoiodoarenes.

  The Journal of organic chemistry 20100205

• Metabolic control of antifungal drug resistance.

  Fungal genetics and biology : FG & B 20100201

• Inhibition of Candida albicans growth by brominated furanones.

  Applied microbiology and biotechnology 20100201

• Photoinactivation of Candida albicans by its own endogenous porphyrins.

  Current microbiology 20100201

• PAP1 [poly(A) polymerase 1] homozygosity and hyperadenylation are major determinants of increased mRNA stability of CDR1 in azole-resistant clinical isolates of Candida albicans.

  Microbiology (Reading, England) 20100201

• Treatment of endemic mycoses.

  Expert review of respiratory medicine 20100201

• The selenazal drug ebselen potently inhibits indoleamine 2,3-dioxygenase by targeting enzyme cysteine residues.

  Biochemistry 20100126

• Opposing regulation of histamine-induced calcium signaling by sodium selenite and ebselen via alterations of thiol redox status.

  European journal of pharmacology 20100125

• Synthesis and anti-viral activity of azolo-adamantanes against influenza A virus.

  Bioorganic & medicinal chemistry 20100115

• NBD-based green fluorescent ligands for typing of thymine-related SNPs by using an abasic site-containing probe DNA.

  Chembiochem : a European journal of chemical biology 20100104

• Treatment outcome of invasive mould disease after sequential exposure to azoles and liposomal amphotericin B.

  The Journal of antimicrobial chemotherapy 20100101

• A new naphthimidazole derivative for saccharide labeling with enhanced sensitivity in mass spectrometry detection.

  Rapid communications in mass spectrometry : RCM 20100101

• Synergistic mechanisms of retigeric acid B and azoles against Candida albicans.

  Journal of applied microbiology 20100101

• In vitro activities of azole antifungal agents against Propionibacterium acnes isolated from patients with acne vulgaris.

  Biological & pharmaceutical bulletin 20100101

• [Update: invasive fungal infections: Diagnosis and treatment in surgical intensive care medicine].

  Der Anaesthesist 20100101

• Expression, purification, and characterization of a recombinant neutral ceramidase from Mycobacterium tuberculosis.

  Bioscience, biotechnology, and biochemistry 20100101

• Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence.

  PloS one 20100101

• Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family.

  BMC biology 20100101

• Antagonistic changes in sensitivity to antifungal drugs by mutations of an important ABC transporter gene in a fungal pathogen.

  PloS one 20100101

• Development of specific inhibitors of CYP707A, a key enzyme in the catabolism of abscisic acid.

  Current medicinal chemistry 20100101

• Candida albicans AGE3, the ortholog of the S. cerevisiae ARF-GAP-encoding gene GCS1, is required for hyphal growth and drug resistance.

  PloS one 20100101

• Beyond ergosterol: linking pH to antifungal mechanisms.

  Virulence 20100101

• [Triazavirin prophylactic efficacy against influenza virus A (H5N1)].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20100101

• Solution versus fluorous versus solid-phase synthesis of 2,5-disubstituted 1,3-azoles. Preliminary antibacterial activity studies.

  The Journal of organic chemistry 20091204

• Comparative mechanisms of zearalenone and ochratoxin A toxicities on cultured HepG2 cells: is oxidative stress a common process?

  Environmental toxicology 20091201

• The current role of amphotericin B lipid complex in managing systemic fungal infections.

  Current medical research and opinion 20091201

• Azole-resistance in Aspergillus: proposed nomenclature and breakpoints.

  Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20091201

• 2-Amino-nonyl-6-methoxyl-tetralin muriate inhibits sterol C-14 reductase in the ergosterol biosynthetic pathway.

  Acta pharmacologica Sinica 20091201

• Inhibitory mechanism of novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferase from Haemophilus influenzae.

  Journal of microbiology and biotechnology 20091201

• Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).

  Chemical communications (Cambridge, England) 20091114

• Towards the mechanism and comparative effect of diphenyl diselenide, diphenyl ditelluride and ebselen under various pathophysiological conditions in rat's kidney preparation.

  Chemico-biological interactions 20091110

• Cryptococcus neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs.

  Molecular microbiology 20091101

• Neuroprotection of ebselen against ischemia/reperfusion injury involves GABA shunt enzymes.

  Journal of the neurological sciences 20091015

• Discovery of highly potent novel antifungal azoles by structure-based rational design.

  Bioorganic & medicinal chemistry letters 20091015

• New azoles with potent antifungal activity: design, synthesis and molecular docking.

  European journal of medicinal chemistry 20091001

• Atypical Aspergillus flavus isolates associated with chronic azole therapy.

  Journal of clinical microbiology 20091001

• Heme oxygenase-1 induction modulates hypoxic pulmonary vasoconstriction through upregulation of ecSOD.

  American journal of physiology. Heart and circulatory physiology 20091001

• Practical catalytic asymmetric synthesis of diaryl-, aryl heteroaryl-, and diheteroarylmethanols.

  Journal of the American Chemical Society 20090902

• 3-imidazolyl-substituted flavans as potential antifungal agents: synthesis, stereochemical properties, and antifungal activity.

  Archiv der Pharmazie 20090901

• New generation azole antifungals in clinical investigation.

  Expert opinion on investigational drugs 20090901

• Structure-based and in silico design of Hsp90 inhibitors.

  ChemMedChem 20090901

• A general copper-catalyzed coupling of azoles with vinyl bromides.

  The Journal of organic chemistry 20090821

• In vitro interactions between antifungals and immunosuppressive drugs against zygomycetes.

  Antimicrobial agents and chemotherapy 20090801

• HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives.

  Bioorganic & medicinal chemistry letters 20090801

• Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury.

  The Journal of surgical research 20090801

• Role of Ndt80p in sterol metabolism regulation and azole resistance in Candida albicans.

  Eukaryotic cell 20090801

• Hsp90 orchestrates stress response signaling governing fungal drug resistance.

  PLoS pathogens 20090801

• The optimal wavelength of spectrophotometric broth microdilution antifungal susceptibility test for flucytosine and three azoles.

  The Korean journal of laboratory medicine 20090801

• Seleniranium ion-triggered reactions: new aspects of Friedel-Crafts and N-detosylative cyclizations.

  Organic letters 20090702

• Discrete generations of intracellular hydrogen peroxide and superoxide in antigen-stimulated mast cells: reciprocal regulation of store-operated Ca2+ channel activity.

  Molecular immunology 20090701

• Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure.

  Emerging infectious diseases 20090701

• Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.

  PLoS pathogens 20090701

• Practical synthesis of a potent bradykinin B(1) antagonist via enantioselective hydrogenation of a pyridyl N-acyl enamide.

  The Journal of organic chemistry 20090619

• Hollow fiber liquid phase microextraction followed by high performance liquid chromatography for determination of ultra-trace levels of Se(IV) after derivatization in urine, plasma and natural water samples.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090615

• Mutations in the CgPDR1 and CgERG11 genes in azole-resistant Candida glabrata clinical isolates from Slovakia.

  International journal of antimicrobial agents 20090601

• Site-specific antiatherogenic effect of the antioxidant ebselen in the diabetic apolipoprotein E-deficient mouse.

  Arteriosclerosis, thrombosis, and vascular biology 20090601

• Ibuprofen reverts antifungal resistance on Candida albicans showing overexpression of CDR genes.

  FEMS yeast research 20090601

• Growth inhibitory action of ebselen on fluconazole-resistant Candida albicans: role of the plasma membrane H+-ATPase.

  Microbial drug resistance (Larchmont, N.Y.) 20090601

• Sterol content analysis suggests altered eburicol 14alpha-demethylase (CYP51) activity in isolates of Mycosphaerella graminicola adapted to azole fungicides.

  FEMS microbiology letters 20090601

• [Antifungals for systemic use].

  Enfermedades infecciosas y microbiologia clinica 20090601

• Antagonists of the P2X(7) receptor. From lead identification to drug development.

  Journal of medicinal chemistry 20090528

• Taguchi OA16 orthogonal array design for the optimization of cloud point extraction for selenium determination in environmental and biological samples by tungsten-modified tube electrothermal atomic absorption spectrometry.

  Talanta 20090515

• Clinical relevance of the pharmacokinetic interactions of azole antifungal drugs with other coadministered agents.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090515

• Modeling the oxidation of ebselen and other organoselenium compounds using explicit solvent networks.

  The journal of physical chemistry. A 20090514

• Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditory cells.

  Hearing research 20090501

• Antifungal drug resistance mechanisms.

  Expert review of anti-infective therapy 20090501

• Azole-resistant central nervous system aspergillosis.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090415

• Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20090415

• Dependence of leukemic cell proliferation and survival on H2O2 and L-arginine.

  Free radical biology & medicine 20090415

• In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.

  Antimicrobial agents and chemotherapy 20090401

• Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance.

  Antimicrobial agents and chemotherapy 20090401

• Overexpression of manganese superoxide dismutase in human dermal fibroblasts enhances the contraction of free floating collagen lattice: implications for ageing and hyperplastic scar formation.

  Archives of dermatological research 20090401

• [Species-specific differences in Rhodamine 6G accumulation of Candida isolates detected by flow cytometric analysis].

  The Korean journal of laboratory medicine 20090401

• Ghrelin receptor modulators and their therapeutic potential.

  Future medicinal chemistry 20090401

• The redox state of glutathione regulates the hypoxic induction of HIF-1.

  European journal of pharmacology 20090315

• Enhancement of iron-catalyzed lipid peroxidation by acidosis in brain homogenate: comparative effect of diphenyl diselenide and ebselen.

  Brain research 20090303

• Susceptibility of Candida albicans to common and novel antifungal drugs, and relationship between the mating type locus and resistance, in Lebanese hospital isolates.

  Mycoses 20090301

• Oral candidiasis of HIV-infected children undergoing sequential HIV therapies.

  Medical mycology 20090301

• Candida spp. in vitro susceptibility profile to four antifungal agents. Resistance surveillance study in Venezuelan strains.

  Medical mycology 20090301

• Susceptibility testing of Cryptococcus diffluens against amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole and posaconazole.

  Medical mycology 20090301

• Redox modulation at the peripheral site alters nociceptive transmission in vivo.

  Clinical and experimental pharmacology & physiology 20090301

• Multiple-azole-resistant Aspergillus fumigatus osteomyelitis in a patient with chronic granulomatous disease successfully treated with long-term oral posaconazole and surgery.

  Medical mycology 20090301

• Guanosine and synthetic organoselenium compounds modulate methylmercury-induced oxidative stress in rat brain cortical slices: involvement of oxidative stress and glutamatergic system.

  Toxicology in vitro : an international journal published in association with BIBRA 20090301

• Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.

  Bioorganic & medicinal chemistry letters 20090301

• Modulation of the antifungal activity of new medicinal plant extracts active on Candida glabrata by the major transporters and regulators of the pleiotropic drug-resistance network in Saccharomyces cerevisiae.

  Microbial drug resistance (Larchmont, N.Y.) 20090301

• Functional analysis of the Kluyveromyces lactis PDR1 gene.

  FEMS yeast research 20090301

• Design of an assembly of poly(benzimidazole), carbon nanotubes, and Pt nanoparticles for a fuel-cell electrocatalyst with an ideal interfacial nanostructure.

  Small (Weinheim an der Bergstrasse, Germany) 20090301

• New antifungal agents in pediatric practice.

  Indian pediatrics 20090301

• Aqueous solvent system for the solubilization of azole compounds.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090215

• Design, synthesis and biological evaluation of a novel class of anticancer agents: anthracenylisoxazole lexitropsin conjugates.

  Bioorganic & medicinal chemistry 20090215

• Synthesis, antitubercular activity and docking study of novel cyclic azole substituted diphenyl ether derivatives.

  European journal of medicinal chemistry 20090201

• Pre-treatment with ebselen and vitamin E modulate acetylcholinesterase activity: interaction with demyelinating agents.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20090201

• Adoptive transfer of syngeneic bone marrow-derived cells in mice with obesity-induced diabetes: selenoorganic antioxidant ebselen restores stem cell competence.

  The American journal of pathology 20090201

• Amyloidophilic compounds for prion diseases.

  Infectious disorders drug targets 20090201

• Clinical indications for newer antifungal agents.

  Journal of hospital medicine 20090201

• Fungal nail infections: diagnosis and management.

  Prescrire international 20090201

• Threshold to N-methyl-D-aspartate-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations.

  The British journal of nutrition 20090201

• Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines.

  Journal of medicinal chemistry 20090108

• Synthesis of telluroamino acid derivatives with remarkable GPx like activity.

  Organic & biomolecular chemistry 20090107

• Antidepressant-like effect of the organoselenium compound ebselen in mice: evidence for the involvement of the monoaminergic system.

  European journal of pharmacology 20090105

• Tetrahydronaphthyl azole oxime ethers: the conformationally rigid analogues of oxiconazole as antibacterials.

  European journal of medicinal chemistry 20090101

• Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5-MmpL5 efflux system.

  Tuberculosis (Edinburgh, Scotland) 20090101

• RTA2 is involved in calcineurin-mediated azole resistance and sphingoid long-chain base release in Candida albicans.

  Cellular and molecular life sciences : CMLS 20090101

• International interlaboratory proficiency testing program for measurement of azole antifungal plasma concentrations.

  Antimicrobial agents and chemotherapy 20090101

• Phosphine-free, palladium-catalyzed arylation of heterocycles through C-H bond activation with pivalic acid as a cocatalyst.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20090101

• Ebselen improves ischemia-reperfusion injury after rat lung transplantation.

  Lung 20090101

• Determination of azole antifungal medicines using zero-order and derivative UV spectrophotometry.

  Acta poloniae pharmaceutica 20090101

• [Determination of 12 azole fungicide residues in beans and corn by offline disperse solid phase extraction and gas chromatography-negative chemical ionization mass spectrometry].

  Se pu = Chinese journal of chromatography 20090101

• Antifungal treatment for invasive Candida infections: a mixed treatment comparison meta-analysis.

  Annals of clinical microbiology and antimicrobials 20090101

• Molecular differentiation and antifungal susceptibility of Candida albicans isolated from patients with respiratory infections in Guiyang Medical College Hospital, China.

  Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20090101

• Detection and antifungal susceptibility testing of oral Candida dubliniensis from human immunodeficiency virus-infected patients.

  Indian journal of pathology & microbiology 20090101

• Effects of N-acetylcysteine and ebselen on arachidonic acid release from astrocytes and neurons cultured in normoxic or simulated ischemic conditions.

  Pharmacological reports : PR 20090101

• [Azole-resistant invasive aspergillosis].

  Nederlands tijdschrift voor geneeskunde 20090101

• How do azoles inhibit cytochrome P450 enzymes? A density functional study.

  The journal of physical chemistry. A 20081218

• CYP51: A major drug target in the cytochrome P450 superfamily.

  Lipids 20081201

• Covalent bonding of azoles to quaternary protoberberine alkaloids.

  Magnetic resonance in chemistry : MRC 20081201

• [What's new in the molecular basis of antifungal drug resistance in pathogenic yeasts].

  Nihon rinsho. Japanese journal of clinical medicine 20081201

• [Cryptococcosis].

  Nihon rinsho. Japanese journal of clinical medicine 20081201

• [Potential of anidulafungin in hematological patients].

  Enfermedades infecciosas y microbiologia clinica 20081201

• [Potential of anidulafungin in combined therapy].

  Enfermedades infecciosas y microbiologia clinica 20081201

• Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.

  The Journal of biological chemistry 20081128

• Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1).

  Journal of medicinal chemistry 20081113

• 1,2,3-Triazol-carboxanilides and 1,2,3-triazol-(N-benzyl)-carboxamides as BK-potassium channel activators. XII.

  European journal of medicinal chemistry 20081101

• Warfarin with fluoroquinolones, sulfonamides, or azole antifungals: interactions and the risk of hospitalization for gastrointestinal bleeding.

  Clinical pharmacology and therapeutics 20081101

• A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus.

  PLoS pathogens 20081101

• Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism.

  PLoS medicine 20081101

• Ebselen attenuates cyclophosphamide-induced oxidative stress and DNA damage in mice.

  Free radical research 20081101

• Activity of amphotericin B, anidulafungin, caspofungin, micafungin, posaconazole, and voriconazole against Candida albicans with decreased susceptibility to fluconazole from APECED patients on long-term azole treatment of chronic mucocutaneous candidiasis.

  Diagnostic microbiology and infectious disease 20081001

• Subculture on potato dextrose agar as a complement to the broth microdilution assay for Malassezia pachydermatis.

  Journal of microbiological methods 20081001

• Cytoplasmic localization of sterol transcription factors Upc2p and Ecm22p in S. cerevisiae.

  Fungal genetics and biology : FG & B 20081001

• Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion.

  Journal of neurochemistry 20081001

• Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus.

  Antimicrobial agents and chemotherapy 20081001

• Azole fungicides: occurrence and fate in wastewater and surface waters.

  Environmental science & technology 20081001

• The requirement of reactive oxygen intermediates for lymphocytic choriomeningitis virus binding and growth.

  Virology 20080930

• Synthesis and antiviral activity of azoles obtained from carbohydrates.

  Carbohydrate research 20080922

• RTA2, a novel gene involved in azole resistance in Candida albicans.

  Biochemical and biophysical research communications 20080905

• Persistent pulmonary infection with an azole-resistant Coccidioides species.

  Medical mycology 20080901

• A case of endocarditis caused by the yeast Pichia fabianii with biofilm production and developed in vitro resistance to azoles in the course of antifungal treatment.

  Medical mycology 20080901

• Lipolytic and esterolytic activity-based profiling of murine liver.

  Proteomics 20080901

• Candida albicans UPC2 is transcriptionally induced in response to antifungal drugs and anaerobicity through Upc2p-dependent and -independent mechanisms.

  Microbiology (Reading, England) 20080901

• The structure of alkali metal derivatives of azoles: N-sigma versus pi structures.

  The journal of physical chemistry. A 20080821

• Determination of physiological thiols by electrochemical detection with piazselenole and its application in rat breast cancer cells 4T-1.

  Journal of the American Chemical Society 20080820

• Synthesis, structure, spectroscopic properties, and antiproliferative activity in vitro of novel osmium(III) complexes with azole heterocycles.

  Inorganic chemistry 20080818

• Copper-mediated N-cyclopropylation of azoles, amides, and sulfonamides by cyclopropylboronic acid.

  The Journal of organic chemistry 20080815

• Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.

  Journal of medicinal chemistry 20080814

• Micafungin activity against Candida albicans with diverse azole resistance phenotypes.

  The Journal of antimicrobial chemotherapy 20080801

• Multilocus sequence typing confirms synonymy but highlights differences between Candida albicans and Candida stellatoidea.

  FEMS yeast research 20080801

• Primary antifungal prophylaxis in hematopoietic stem cell transplant recipients: clinical implications of recent studies.

  Current opinion in infectious diseases 20080801

• Hydrolysis and cytotoxic properties of osmium(II)/(III)-DMSO-azole complexes. Short communication.

  Chemistry & biodiversity 20080801

• Copper complexes of anionic nitrogen ligands in the amidation and imidation of aryl halides.

  Journal of the American Chemical Society 20080730

• Selenium compounds counteract the stimulation of ecto-nucleotidase activities in rat cultured cerebellar granule cells: putative correlation with neuroprotective effects.

  Brain research 20080724

• Optimization of azoles as anti-human immunodeficiency virus agents guided by free-energy calculations.

  Journal of the American Chemical Society 20080723

• Immunocompromised hosts: immunopharmacology of modern antifungals.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080715

• Synthesis, potent anti-staphylococcal activity and QSARs of some novel 2-anilinobenzazoles.

  European journal of medicinal chemistry 20080701

• A phase 2, open-label study of the safety and efficacy of intravenous anidulafungin as a treatment for azole-refractory mucosal candidiasis.

  Journal of acquired immune deficiency syndromes (1999) 20080701

• Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.

  Bioorganic & medicinal chemistry 20080615

• Design, synthesis, characterization, antibacterial and antifungal activities of a novel class of 5,7-diaryl-4,4-dimethyl-4,5,6,7-tetrahydropyridino[3,4-d]-1,2,3-selenadiazoles.

  Journal of enzyme inhibition and medicinal chemistry 20080601

• Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat.

  Neuroscience 20080502

• Semi-national surveillance of fungaemia in Denmark 2004-2006: increasing incidence of fungaemia and numbers of isolates with reduced azole susceptibility.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20080501

• Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance.

  Eukaryotic cell 20080501

• Characterization of caspofungin susceptibilities by broth and agar in Candida albicans clinical isolates with characterized mechanisms of azole resistance.

  Medical mycology 20080501

• New options for treatment of candidaemia in critically ill patients.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20080501

• Divergent functions of three Candida albicans zinc-cluster transcription factors (CTA4, ASG1 and CTF1) complementing pleiotropic drug resistance in Saccharomyces cerevisiae.

  Microbiology (Reading, England) 20080501

• Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein.

  The Journal of biological chemistry 20080418

• Overanticoagulation with coumarin and cutaneous azole therapy.

  Annals of internal medicine 20080415

• Ebselen attenuates cadmium-induced testicular damage in mice.

  Journal of applied toxicology : JAT 20080401

• Endocrine-disrupting properties in vivo of widely used azole fungicides.

  International journal of andrology 20080401

• An azole, an amide and a limonoid from Vepris uguenensis (Rutaceae).

  Phytochemistry 20080401

• The ATP-binding cassette transporter-encoding gene CgSNQ2 is contributing to the CgPDR1-dependent azole resistance of Candida glabrata.

  Molecular microbiology 20080401

• Synergistic activity of azoles with amiodarone against clinically resistant Candida albicans tested by chequerboard and time-kill methods.

  Journal of medical microbiology 20080401

• Characterization of type II ligands in CYP2C9 and CYP3A4.

  Journal of medicinal chemistry 20080327

• Involvement of peroxynitrite in pollen-induced nasal blockage in guinea pigs.

  European journal of pharmacology 20080317

• Mechanistic studies of a palladium-catalyzed intramolecular hydroamination of unactivated alkenes: protonolysis of a stable palladium alkyl complex is the turnover-limiting step.

  Journal of the American Chemical Society 20080305

• In vitro interaction between azoles and cyclosporin A against clinical isolates of Candida albicans determined by the chequerboard method and time-kill curves.

  The Journal of antimicrobial chemotherapy 20080301

• Antioxidant and anti-mutagenic effects of ebselen in yeast and in cultured mammalian V79 cells.

  Mutagenesis 20080301

• Ebselen increases cytosolic free Ca2+ concentration, stimulates glutamate release and increases GFAP content in rat hippocampal astrocytes.

  Toxicology 20080227

• Rh(I)-catalyzed arylation of heterocycles via C-H bond activation: expanded scope through mechanistic insight.

  Journal of the American Chemical Society 20080227

• Ebselen, a redox regulator containing a selenium atom, induces neurofilament M expression in cultured rat pheochromocytoma PC12 cells via activation of mitogen-activated protein kinase.

  Journal of neuroscience research 20080215

• Aryl azoles with neuroprotective activity--parallel synthesis and attempts at target identification.

  Bioorganic & medicinal chemistry 20080215

• Effect of substituents on the GPx-like activity of ebselen: steric versus electronic.

  The journal of physical chemistry. A 20080207

• Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression.

  Drug metabolism and disposition: the biological fate of chemicals 20080201

• Effects of fluorescent probe NBD-PC on the structure, dynamics and phase transition of DPPC. A molecular dynamics and differential scanning calorimetry study.

  Biochimica et biophysica acta 20080201

• Azole antifungals induce up-regulation of SAP4, SAP5 and SAP6 secreted proteinase genes in filamentous Candida albicans cells in vitro and in vivo.

  The Journal of antimicrobial chemotherapy 20080201

• Intermolecular hydroaminations via strained (E)-cycloalkenes.

  The Journal of organic chemistry 20080201

• Total synthesis of thiopeptide antibiotics GE2270A, GE2270T, and GE2270C1.

  Chemistry, an Asian journal 20080201

• Synthesis and anticandidal activity of azole-containing sulfonamides.

  Archiv der Pharmazie 20080201

• [Successful treatment of azole-refractory Candida guilliermondii fungemia with a combination therapy of micafungin and liposomal amphotericin B].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 20080201

• Antifungal serum concentration monitoring: an update.

  The Journal of antimicrobial chemotherapy 20080101

• In vitro interactions between azoles and amiodarone against clinical Candida albicans.

  International journal of antimicrobial agents 20080101

• 2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents.

  Bioorganic & medicinal chemistry letters 20080101

• 'Click' dendrimers: synthesis, redox sensing of Pd(OAc)2, and remarkable catalytic hydrogenation activity of precise Pd nanoparticles stabilized by 1,2,3-triazole-containing dendrimers.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• Antifungal drugs.

  Treatment guidelines from the Medical Letter 20080101

• Toward basic understanding of the partition coefficient log P and its application in QSAR.

  SAR and QSAR in environmental research 20080101

• In search of the holy grail of antifungal therapy.

  Transactions of the American Clinical and Climatological Association 20080101

• Antioxidant activity of the anti-inflammatory compound ebselen: a reversible cyclization pathway via selenenic and seleninic acid intermediates.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• Alpha-lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine.

  Surgery today 20080101

• Synthesis, characterization and antimicrobial activity of new 1,2,3-selenadiazoles.

  Molecules (Basel, Switzerland) 20080101

• Reduction of vesicant toxicity by butylated hydroxyanisole in A-431 skin cells.

  Cutaneous and ocular toxicology 20080101

• Molecular properties relevant to bioavailability of tioconazole and its derivatives.

  Acta poloniae pharmaceutica 20080101

• Development of CXCR3 antagonists. Part 2: Identification of 2-amino(4-piperidinyl)azoles as potent CXCR3 antagonists.

  Bioorganic & medicinal chemistry letters 20071215

• Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51.

  The Journal of biological chemistry 20071214

• The Candida glabrata putative sterol transporter gene CgAUS1 protects cells against azoles in the presence of serum.

  The Journal of antimicrobial chemotherapy 20071201

• cis-Acting elements within the Candida albicans ERG11 promoter mediate the azole response through transcription factor Upc2p.

  Eukaryotic cell 20071201

• [Chronic ethanol feeding induces oxidative stress in the rat retina: treatment with the antioxidant ebselen].

  Archivos de la Sociedad Espanola de Oftalmologia 20071201

• Ebselen attenuates oxidative DNA damage and enhances its repair activity in the thalamus after focal cortical infarction in hypertensive rats.

  Brain research 20071121

• Oxidative addition of 2-substituted azolium salts to Group-10 metal zero complexes--a DFT study.

  Dalton transactions (Cambridge, England : 2003) 20071107

• Antifungal activity of statins against Aspergillus species.

  Medical mycology 20071101

• Species distribution and susceptibility to azole antifungals of Candida bloodstream isolates from eight university hospitals in Korea.

  Yonsei medical journal 20071031

• Copper(I)-catalyzed highly efficient synthesis of benzoselenazoles and benzotellurazoles.

  The Journal of organic chemistry 20071012

• (45)Ca(2+) influx in rat brain: effect of diorganylchalcogenides compounds.

  Toxicological sciences : an official journal of the Society of Toxicology 20071001

• Ebselen reduces nitration and restores voltage-gated potassium channel function in small coronary arteries of diabetic rats.

  American journal of physiology. Heart and circulatory physiology 20071001

• Improved outcomes associated with advances in therapy for invasive fungal infections in immunocompromised hosts.

  The Journal of infection 20071001

• Decreased susceptibility of Candida albicans to azole antifungals: a complication of long-term treatment in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients.

  The Journal of antimicrobial chemotherapy 20071001

• Carbon monoxide stimulates the Ca2(+)-activated big conductance k channels in cultured human endothelial cells.

  Hypertension (Dallas, Tex. : 1979) 20071001

• 3,3'-diselenodipropionic acid, an efficient peroxyl radical scavenger and a GPx mimic, protects erythrocytes (RBCs) from AAPH-induced hemolysis.

  Chemical research in toxicology 20071001

• Synthesis and biological evaluation of 3-(azolylmethyl)-1H-indoles and 3-(alpha-azolylbenzyl)-1H-indoles as selective aromatase inhibitors.

  Journal of enzyme inhibition and medicinal chemistry 20071001

• Dynamics of membrane protein/amphipol association studied by Förster resonance energy transfer: implications for in vitro studies of amphipol-stabilized membrane proteins.

  Biochemistry 20070911

• Azole therapy of clinical and experimental coccidioidomycosis.

  Annals of the New York Academy of Sciences 20070901

• Chemotherapeutic evaluation of alginate nanoparticle-encapsulated azole antifungal and antitubercular drugs against murine tuberculosis.

  Nanomedicine : nanotechnology, biology, and medicine 20070901

• The diverse chemistry of oxazol-5-(4H)-ones.

  Chemical Society reviews 20070901

• Surface modification of cetyltrimethylammonium bromide-capped gold nanorods to make molecular probes.

  Langmuir : the ACS journal of surfaces and colloids 20070814

• Synthesis and evaluation of novel 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols as antifungal agents.

  European journal of medicinal chemistry 20070801

• Lung toxicity of nitrogen mustard may be mediated by nitric oxide and peroxynitrite in rats.

  Research in veterinary science 20070801

• Treatment of acute Old World cutaneous leishmaniasis: a systematic review of the randomized controlled trials.

  Journal of the American Academy of Dermatology 20070801

• Enantioselective separation of azole compounds by EKC. Reversal of migration order of enantiomers with CD concentration.

  Electrophoresis 20070801

• Novel inhibitors of VEGF receptors-1 and -2 based on azole-5-carboxamide templates.

  Bioorganic & medicinal chemistry letters 20070701

• Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae.

  Eukaryotic cell 20070701

• Identification of Y118 amino acid residue in Candida albicans sterol 14alpha-demethylase associated with the enzyme activity and selective antifungal activity of azole analogues.

  Biological & pharmaceutical bulletin 20070701

• Previous treatment with ebselen and vitamin E alters adenine nucleotide hydrolysis in platelets from adult rats experimentally demyelinated with ethidium bromide.

  Life sciences 20070627

• Diverse functionalization of thiazolo ring-fused 2-pyridones.

  The Journal of organic chemistry 20070622

• Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).

  Bioorganic & medicinal chemistry letters 20070615

• Ebselen and diorganylchalcogenides decrease in vitro glutamate uptake by rat brain slices: prevention by DTT and GSH.

  Toxicology in vitro : an international journal published in association with BIBRA 20070601

• Synthesis of azole nucleoside analogues of D-pinitol as potential antitumor agents.

  Carbohydrate research 20070507

• Monitoring the looping up of acyl chain labeled NBD lipids in membranes as a function of membrane phase state.

  Biochimica et biophysica acta 20070501

• Deficient peroxide detoxification underlies the susceptibility of oligodendrocyte progenitors to dopamine toxicity.

  Neuropharmacology 20070501

• Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans.

  Molecular microbiology 20070501

• Transmembrane transport of peptidoglycan precursors across model and bacterial membranes.

  Molecular microbiology 20070501

• Ebselen protects brain, skin, lung and blood cells from mechlorethamine toxicity.

  Toxicology and industrial health 20070501

• Density functional theory study of the reaction mechanism and energetics of the reduction of hydrogen peroxide by ebselen, ebselen diselenide, and ebselen selenol.

  The journal of physical chemistry. A 20070426

• Ebselen treatment reduces noise induced hearing loss via the mimicry and induction of glutathione peroxidase.

  Hearing research 20070401

• Role of endogenous hydrogen peroxide in the development of nitrate tolerance.

  Vascular pharmacology 20070401

• Antifungal susceptibility of 1000 Candida bloodstream isolates to 5 antifungal drugs: results of a multicenter study conducted in São Paulo, Brazil, 1995-2003.

  Diagnostic microbiology and infectious disease 20070401

• Synthesis and antibacterial activity of some 5-(4-biphenylyl)-7-aryl [3,4-d]-1,2,3-benzoselenadiazoles.

  Journal of enzyme inhibition and medicinal chemistry 20070401

• Enantiomeric separation of several antimycotic azole drugs using supercritical fluid chromatography.

  Journal of chromatography. A 20070316

• Location and dynamics of acyl chain NBD-labeled phosphatidylcholine (NBD-PC) in DPPC bilayers. A molecular dynamics and time-resolved fluorescence anisotropy study.

  Biochimica et biophysica acta 20070301

• ortho-Substituted azoles as selective and dual inhibitors of VEGF receptors 1 and 2.

  Bioorganic & medicinal chemistry letters 20070301

• Spontaneous, intervesicular transfer rates of fluorescent, acyl chain-labeled phosphatidylcholine analogs.

  Biochimica et biophysica acta 20070301

• Differential reactivity of alpha and beta 2'-deoxyribonucleosides towards protonation and metalation.

  Journal of inorganic biochemistry 20070301

• Antifungal activities of azole agents against the Malassezia species.

  International journal of antimicrobial agents 20070301

• Ebselen prevents chronic alcohol-induced rat hippocampal stress and functional impairment.

  Alcoholism, clinical and experimental research 20070301

• [Mechanisms of resistance to antifungal agents].

  Nihon rinsho. Japanese journal of clinical medicine 20070227

• N-Acetylcysteine and ebselen but not nifedipine protected cerebellar granule neurons against 4-hydroxynonenal-induced neuronal death.

  Neuroscience research 20070201

• Synthesis, characterization, and antioxidant activity of some ebselen analogues.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

• Antifungal drug susceptibility of Cryptococcus neoformans from clinical sources in Nairobi, Kenya.

  Mycoses 20070101

• Voriconazole resistant Candida spp. and Saccharomyces spp. isolates from oropharyngeal candidiasis from Cambodian children with AIDS not pretreated with azoles (letter).

  Scandinavian journal of infectious diseases 20070101

• [The role of sterols in morphogenetic processes and dimorphism in fungi].

  Mikrobiologiia 20070101

• Fluorescent fructose derivatives for imaging breast cancer cells.

  Bioconjugate chemistry 20070101

• Synthesis and evaluation of new difluoromethyl azoles as antileishmanial agents.

  European journal of medicinal chemistry 20070101

• Safety and efficacy of posaconazole in the long-term treatment of azole-refractory oropharyngeal and esophageal candidiasis in patients with HIV infection.

  HIV clinical trials 20070101

• Synthesis of novel N-rich polycyclic skeletons based on azoles and pyridines.

  Journal of combinatorial chemistry 20070101

• A method for determination of selenium in organic tissues using microwave digestion and liquid chromatography.

  Journal of AOAC International 20070101

• Discovery and development of ATPase inhibitors of DNA gyrase as antibacterial agents.

  Current medicinal chemistry 20070101

• New noninvasive methodology for real-time monitoring of lipid flip.

  Bioconjugate chemistry 20070101

• [Treatment of fungal infections of upper respiratory tract and ear].

  Otolaryngologia polska = The Polish otolaryngology 20070101

• Evaluation of the antimicrobial activity of ebselen: role of the yeast plasma membrane H+-ATPase.

  Journal of biochemical and molecular toxicology 20070101

• Effects of ebselen on glutathione level in neurons exposed to arachidonic acid and 4-hydroxynonenal during simulated ischemia in vitro.

  Pharmacological reports : PR 20070101

• Species distribution and susceptibility to azoles of vaginal yeasts isolated prostitutes.

  Infectious diseases in obstetrics and gynecology 20070101

• [Investigation of triazavirin antiviral activity against influenza A virus (H5N1) in cell culture].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20070101

• Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode.

  The Journal of biological chemistry 20061222

• CYP121, CYP51 and associated redox systems in Mycobacterium tuberculosis: towards deconvoluting enzymology of P450 systems in a human pathogen.

  Biochemical Society transactions 20061201

• Factors influencing the magnitude and clinical significance of drug interactions between azole antifungals and select immunosuppressants.

  Pharmacotherapy 20061201

• Cardioprotective effects of subcutaneous ebselen against daunorubicin-induced cardiomyopathy in rats.

  Basic & clinical pharmacology & toxicology 20061201

• Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles.

  Toxicology 20061110

• Diphenyl diselenide reduces temporarily hyperglycemia: possible relationship with oxidative stress.

  Chemico-biological interactions 20061107

• Ebselen effects on MPTP-induced neurotoxicity.

  Brain research 20061106

• In vitro activity and synergism of amphotericin B, azoles and cationic antimicrobials against the emerging pathogen Trichoderma spp.

  The Journal of antimicrobial chemotherapy 20061101

• Oral pretreatment with ebselen enhances heat shock protein 72 expression and reduces myocardial infarct size.

  Hypertension research : official journal of the Japanese Society of Hypertension 20061101

• Horseradish peroxidase inhibition and antioxidant activity of ebselen and related organoselenium compounds.

  Bioorganic & medicinal chemistry letters 20061015

• Inexpensive, one-pot synthesis of unsymmetrical disulfides using 1-chlorobenzotriazole.

  The Journal of organic chemistry 20061013

• Heterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2.

  Molecular microbiology 20061001

• Oxidative stress induces ADAM9 protein expression in human prostate cancer cells.

  Cancer research 20061001

• Role of enteral nutrition supplemented with ebselen and EHEC in pancreatitis-associated multiple organ dysfunction in rats.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20061001

• Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis.

  Apoptosis : an international journal on programmed cell death 20060901

• Protective effect of ebselen, a selenoorganic drug, against gentamicin-induced renal damage in rats.

  Basic & clinical pharmacology & toxicology 20060901

• Ebselen, a seleno-organic antioxidant, as an electrophile.

  Chemical research in toxicology 20060901

• Small-molecule screening identifies the selanazal drug ebselen as a potent inhibitor of DMT1-mediated iron uptake.

  Chemistry & biology 20060901

• Effect of selenium compounds on the damage induced by oxysterol on rat arterial walls.

  Biological trace element research 20060901

• Reactive oxygen species mediate phorbol ester-stimulated cAMP response in human eosinophils.

  European journal of pharmacology 20060814

• Cloning and characterization of CYP51 from Mycobacterium avium.

  American journal of respiratory cell and molecular biology 20060801

• Proteomic analysis of experimentally induced azole resistance in Candida glabrata.

  The Journal of antimicrobial chemotherapy 20060801

• Caspofungin activity against clinical isolates of azole cross-resistant Candida glabrata overexpressing efflux pump genes.

  The Journal of antimicrobial chemotherapy 20060801

• Pdr1 regulates multidrug resistance in Candida glabrata: gene disruption and genome-wide expression studies.

  Molecular microbiology 20060801

• Treatment options of invasive fungal infections in adults.

  Swiss medical weekly 20060722

• Aneuploidy and isochromosome formation in drug-resistant Candida albicans.

  Science (New York, N.Y.) 20060721

• Modeling the reduction of hydrogen peroxide by glutathione peroxidase mimics.

  The journal of physical chemistry. A 20060720

• Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen.

  Brain : a journal of neurology 20060701

• Classical QSAR study on chromene derivatives as lanosterol 14alpha- demethylase inhibitor: a non azole antifungal target.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20060701

• Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense.

  Journal of natural products 20060701

• A new non-azole inhibitor of ABA 8'-hydroxylase: effect of the hydroxyl group substituted for geminal methyl groups in the six-membered ring.

  Bioorganic & medicinal chemistry letters 20060615

• Direct assay for alpha-amylase using fluorophore-modified cyclodextrins.

  Bioorganic & medicinal chemistry 20060601

• Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans.

  The Journal of antimicrobial chemotherapy 20060601

• In vitro antifungal susceptibility to six antifungal agents of 229 Candida isolates from patients with diabetes mellitus.

  Oral microbiology and immunology 20060601

• Design of clinical trials of empiric antifungal therapy in patients with persistent febrile neutropenia: considerations and critiques.

  Pharmacotherapy 20060601

• Treatment options for invasive fungal infections.

  Pharmacotherapy 20060601

• Emerging antifungal azoles and effects on Magnaporthe grisea.

  Mycological research 20060601

• PDR16-mediated azole resistance in Candida albicans.

  Molecular microbiology 20060601

• Measuring translocation of fluorescent lipid derivatives across yeast Golgi membranes.

  Methods (San Diego, Calif.) 20060601

• Antileishmanial activities and mechanisms of action of indole-based azoles.

  Journal of enzyme inhibition and medicinal chemistry 20060601

• Synthesis and antifungal activity of new thienyl and aryl conazoles.

  Journal of enzyme inhibition and medicinal chemistry 20060601

• Solid-phase synthesis of 1,3-azole-based peptides and peptidomimetics.

  Organic letters 20060525

• Neuroprotective effects of ebselen are associated with the regulation of Bcl-2 and Bax proteins in cultured mouse cortical neurons.

  Neuroscience letters 20060522

• Nitric oxide inhibits HIF-1alpha protein accumulation under hypoxic conditions: implication of 2-oxoglutarate and iron.

  Biochimie 20060501

• Synthesis and antifungal activities of some aryl [3-(imidazol-1-yl/triazol-1-ylmethyl) benzofuran-2-yl] ketoximes.

  European journal of medicinal chemistry 20060501

• Diphenyl ditelluride- and methylmercury-induced hyperphosphorilation of the high molecular weight neurofilament subunit is prevented by organoselenium compounds in cerebral cortex of young rats.

  Toxicology 20060501

• Ebselen induced C6 glioma cell death in oxygen and glucose deprivation.

  Chemical research in toxicology 20060501

• Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking.

  Journal of medicinal chemistry 20060420

• Drug interactions during therapy with three major groups of antimicrobial agents.

  Expert opinion on pharmacotherapy 20060401

• Pharmaceutical prescribing for children. Part 4. Antifungal and antiviral therapy.

  Primary dental care : journal of the Faculty of General Dental Practitioners (UK) 20060401

• Effect of azoles on the secretion of a Candida albicans metallopeptidase.

  Mycopathologia 20060301

• Protective effect of ebselen on cytotoxicity induced by cholestane-3 beta, 5 alpha, 6 beta-triol in ECV-304 cells.

  Biochimica et biophysica acta 20060301

• Substituent effects on enthalpies of formation of nitrogen heterocycles: 2-substituted benzimidazoles and related compounds.

  The journal of physical chemistry. A 20060223

• Inhibition of human CYP19 by azoles used as antifungal agents and aromatase inhibitors, using a new LC-MS/MS method for the analysis of estradiol product formation.

  Toxicology 20060215

• Immobilization stress induces cell death through production of reactive oxygen species in the mouse cerebral cortex.

  Neuroscience letters 20060109

• Beneficial effects of Ebselen on corrosive esophageal burns of rats.

  International journal of pediatric otorhinolaryngology 20060101

• Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice.

  American journal of physiology. Regulatory, integrative and comparative physiology 20060101

• Lifetime fluorescence method for determining membrane topology of proteins.

  Analytical biochemistry 20060101

• In vitro activities of caspofungin, amphotericin B and azoles against Coccidioides posadasii strains from Northeast, Brazil.

  Mycopathologia 20060101

• The statins: drug interactions of significance to the dental practitioner.

  Dental update 20060101

• Ebselen attenuates oxidative stress in ischemic astrocytes depleted of glutathione. Comparison with glutathione precursors.

  Pharmacological reports : PR 20060101

• The protective effects of selenoorganic compounds against peroxynitrite-induced changes in plasma proteins and lipids.

  Cellular & molecular biology letters 20060101

• Limitations of caspofungin in the treatment of obstructive pyonephrosis due to Candida glabrata infection.

  BMC infectious diseases 20060101

• [Studies on the correlation of the method currently used by the Japanese Society for Medical Mycology and its modified method with the NCCLS M27-A2 microdilution method for azole susceptibility testing of Candida species].

  Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20060101

• A new, broad-spectrum azole antifungal: posaconazole--mechanisms of action and resistance, spectrum of activity.

  Mycoses 20060101

• [Antifungals cellular targets and mechanisms of resistance].

  Therapie 20060101

• [Emerging azole antifungals].

  Therapie 20060101

• In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species.

  BMC infectious diseases 20060101

• Design and biological evaluation of photo-switchable inhibitors.

  Genome informatics. International Conference on Genome Informatics 20060101

• Current status and future of antifungal therapy for systemic mycoses.

  Recent patents on anti-infective drug discovery 20060101

• Analysis of pesticides in fruits by pressurized liquid extraction and liquid chromatography-ion trap-triple stage mass spectrometry.

  Journal of chromatography. A 20051209

• Skeleton-selective fluorescent chemosensor based on cyclodextrin bearing a 4-amino-7-nitrobenz-2-oxa-1,3-diazole moiety.

  Organic & biomolecular chemistry 20051207

• Endothelin mediates superoxide production and vasoconstriction through activation of NADPH oxidase and uncoupled nitric-oxide synthase in the rat aorta.

  The Journal of pharmacology and experimental therapeutics 20051201

• Current state of three-dimensional characterisation of antifungal targets and its use for molecular modelling in drug design.

  International journal of antimicrobial agents 20051201

• Identification of the structural requirements of the receptor-binding affinity of diphenolic azoles to estrogen receptors alpha and beta by three-dimensional quantitative structure-activity relationship and structure-activity relationship analysis.

  Journal of medicinal chemistry 20051201

• Design, synthesis, and microbiological evaluation of new Candida albicans CYP51 inhibitors.

  Journal of medicinal chemistry 20051201

• Fungal infections of the skin: infection process and antimycotic therapy.

  Current drug targets 20051201

• Currently used antimycotics: spectrum, mode of action and resistance occurrence.

  Current drug targets 20051201

• Effect of diphenyl diselenide, diphenyl ditelluride and ebselen on cerebral Na(+), K(+)-ATPase activity in rats.

  Toxicology 20051115

• Frequency of potential azole drug-drug interactions and consequences of potential fluconazole drug interactions.

  Pharmacoepidemiology and drug safety 20051101

• Peroxynitrite hyperpolarizes smooth muscle and relaxes internal carotid artery in rabbit via ATP-sensitive K+ channels.

  American journal of physiology. Heart and circulatory physiology 20051101

• Azole susceptibility and resistance in Candida dubliniensis.

  Biochemical Society transactions 20051101

• Metal ion coordination to azole nucleosides.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20051021

• Ebselen protects glutamate uptake inhibition caused by methyl mercury but does not by Hg2+.

  Toxicology 20051015

• Compounds for the prevention and treatment of noise-induced hearing loss.

  Drug discovery today 20051001

• Versatile access to C-4-substituted 2-amino-1,3-azoles from hydropyridines in oxidative conditions.

  The Journal of organic chemistry 20050930

• New multi-1,2,3-selenadiazole aromatic derivatives.

  Molecules (Basel, Switzerland) 20050930

• Nano-encapsulation of azole antifungals: potential applications to improve oral drug delivery.

  International journal of pharmaceutics 20050914

• Ebselen: a thioredoxin reductase-dependent catalyst for alpha-tocopherol quinone reduction.

  Toxicology and applied pharmacology 20050901

• Recent developments in cannabinoid ligands.

  Life sciences 20050819

• Glutathione peroxidase (GPx)-like antioxidant activity of the organoselenium drug ebselen: unexpected complications with thiol exchange reactions.

  Journal of the American Chemical Society 20050817

• Quantitation of 13 azole fungicides in wine samples by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. A 20050812

• Sterol uptake in Candida glabrata: rescue of sterol auxotrophic strains.

  Diagnostic microbiology and infectious disease 20050801

• Synthesis, characterization and biological activity of triorganotin 2-phenyl-1,2,3-triazole-4-carboxylates.

  Journal of inorganic biochemistry 20050801

• Antifungal treatment in pediatric patients.

  Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20050801

• Aspirochlorine class compounds from Aspergillus flavus inhibit azole-resistant Candida albicans.

  Journal of natural products 20050801

• CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions.

  The Journal of pharmacology and experimental therapeutics 20050701

• Ebselen attenuates haloperidol-induced orofacial dyskinesia and oxidative stress in rat brain.

  Pharmacology, biochemistry, and behavior 20050701

• NADPH oxidase is required for NMDA receptor-dependent activation of ERK in hippocampal area CA1.

  Journal of neurochemistry 20050701

• Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic. Insights into the interaction of ebselen with mitochondria.

  The Journal of biological chemistry 20050624

• Ebselen prevents noise-induced excitotoxicity and temporary threshold shift.

  Neuroscience letters 20050603

• Synthesis and characterization of azole isoflavone inhibitors of aromatase.

  Bioorganic & medicinal chemistry 20050602

• Organoselenium compounds prevent hyperphosphorylation of cytoskeletal proteins induced by the neurotoxic agent diphenyl ditelluride in cerebral cortex of young rats.

  Toxicology 20050601

• Combined oral delivery of ebselen and allopurinol reduces multiple cisplatin toxicities in rat breast and ovarian cancer models while enhancing anti-tumor activity.

  Anti-cancer drugs 20050601

• Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans.

  Antimicrobial agents and chemotherapy 20050601

• Antifungal activities of tacrolimus and azole agents against the eleven currently accepted Malassezia species.

  Journal of clinical microbiology 20050601

• Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs.

  The Journal of pharmacy and pharmacology 20050601

• Determination of azolic fungicides in wine by solid-phase extraction and high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.

  Journal of chromatography. A 20050527

• Selenium compounds prevent the effects of methylmercury on the in vitro phosphorylation of cytoskeletal proteins in cerebral cortex of young rats.

  Toxicological sciences : an official journal of the Society of Toxicology 20050501

• Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes.

  The Journal of antimicrobial chemotherapy 20050501

• Peroxynitrite may be involved in bladder damage caused by cyclophosphamide in rats.

  The Journal of urology 20050501

• Effects of Y132H and F145L substitutions on the activity, azole resistance and spectral properties of Candida albicans sterol 14-demethylase P450 (CYP51): a live example showing the selection of altered P450 through interaction with environmental compounds.

  Journal of biochemistry 20050501

• Azole and fungicide resistance in clinical and environmental Aspergillus fumigatus isolates.

  Medical mycology 20050501

• The ergosterol biosynthesis pathway, transporter genes, and azole resistance in Aspergillus fumigatus.

  Medical mycology 20050501

• Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.

  Journal of medicinal chemistry 20050421

• Regulation of azole drug susceptibility by Candida albicans protein kinase CK2.

  Molecular microbiology 20050401

• Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers.

  Current drug targets. CNS and neurological disorders 20050401

• Effect of ebselen and organochalcogenides on excitotoxicity induced by glutamate in isolated chick retina.

  Brain research 20050328

• Structural diversities of active site in clinical azole-bound forms between sterol 14alpha-demethylases (CYP51s) from human and Mycobacterium tuberculosis.

  The Journal of biological chemistry 20050311

• Reduction of acute cisplatin ototoxicity and nephrotoxicity in rats by oral administration of allopurinol and ebselen.

  Hearing research 20050301

• Synthesis and spectroscopic characterisation of new ESIPT fluorescent protein probes.

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20050301

• [Synthesis of byrazoline fluorescent compounds and studies by infrared spectroscopy].

  Guang pu xue yu guang pu fen xi = Guang pu 20050301

• Neuroprotective effects of ebselen on experimental spinal cord injury in rats.

  Neurochemical research 20050301

• Protective effect of antioxidant ebselen (PZ51) on the cerebral cortex of stroke-prone spontaneously hypertensive rats.

  Hypertension research : official journal of the Japanese Society of Hypertension 20050301

• New agents for invasive mycoses in children.

  Current opinion in pediatrics 20050201

• Antifungal drugs.

  Treatment guidelines from the Medical Letter 20050201

• Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance.

  Antimicrobial agents and chemotherapy 20050201

• Involvement of peroxynitrite in capsaicin-induced apoptosis of C6 glioma cells.

  Neuroscience research 20050201

• Emerging azole antifungals.

  Expert opinion on emerging drugs 20050201

• Second-generation azole antifungal agents.

  Drugs of today (Barcelona, Spain : 1998) 20050201

• Hypoxia-induced dysfunction of rat diaphragm: role of peroxynitrite.

  American journal of physiology. Lung cellular and molecular physiology 20050101

• Solid-phase synthesis of 5-amino-1-(substituted thiocarbamoyl)pyrazole and 1,2,4-triazole derivatives via dithiocarbazate linker.

  Journal of combinatorial chemistry 20050101

• Characterization and properties of cholesterol desaturases from the ciliate Tetrahymena thermophila.

  The Journal of eukaryotic microbiology 20050101

• Kinetic studies of the radical-scavenging activity of ebselen, a seleno-organic compound.

  Anticancer research 20050101

• [Synthesis and antiviral activity of new 5-substituted 2'-deoxyuridine derivatives].

  Bioorganicheskaia khimiia 20050101

• Effect of glutathione peroxidase mimic ebselen (PZ51) on endothelium and vascular structure of stroke-prone spontaneously hypertensive rats.

  Blood pressure 20050101

• Glyoxylic acid and MP-glyoxylate: efficient formaldehyde equivalents in the 3-CC of 2-aminoazines, aldehydes, and isonitriles.

  Organic letters 20041223

• Oral Candida isolates in patients undergoing radiotherapy for head and neck cancer: prevalence, azole susceptibility profiles and response to antifungal treatment.

  Oral microbiology and immunology 20041201

• Endothelial dysfunction as a modifier of angiogenic response in Zucker diabetic fat rat: amelioration with Ebselen.

  Kidney international 20041201

• TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2.

  Eukaryotic cell 20041201

• The effects of ebselen on [3H]glutamate uptake by synaptic vesicles from rat brain.

  Brain research 20041119

• Protective effects on neuronal cells of mouse afforded by ebselen against oxidative stress at multiple steps.

  Neuroscience letters 20041116

• Ebselen augments its peroxidase activity by inducing nrf-2-dependent transcription.

  Archives of biochemistry and biophysics 20041115

• Combinations of antifungal agents in therapy--what value are they?

  The Journal of antimicrobial chemotherapy 20041101

• Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ring.

  Bioorganic & medicinal chemistry 20041101

• Potent antitumor activity of novel iron chelators derived from di-2-pyridylketone isonicotinoyl hydrazone involves fenton-derived free radical generation.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20041101

• Azaanalogues of ebselen as antimicrobial and antiviral agents: synthesis and properties.

  Farmaco (Societa chimica italiana : 1989) 20041101

• Combination antifungal therapy: where are we now, and where are we going?

  Oncology (Williston Park, N.Y.) 20041101

• Thermodynamic and biophysical characterization of cytochrome P450 BioI from Bacillus subtilis.

  Biochemistry 20041005

• Oxidant activity in skeletal muscle fibers is influenced by temperature, CO2 level, and muscle-derived nitric oxide.

  American journal of physiology. Regulatory, integrative and comparative physiology 20041001

• Posaconazole is a potent inhibitor of sterol 14alpha-demethylation in yeasts and molds.

  Antimicrobial agents and chemotherapy 20041001

• Synthesis and anti-tuberculosis activity of N-aryl-C-nitroazoles.

  European journal of medicinal chemistry 20041001

• Synthesis and antimycobacterial activity of pyridylmethylsulfanyl and naphthylmethylsulfanyl derivatives of benzazoles, 1, 2, 4-triazole, and pyridine-2-carbothioamide/-2-carbonitrile.

  Archiv der Pharmazie 20041001

• Pathogenesis of allergic bronchopulmonary aspergillosis and an evidence-based review of azoles in treatment.

  Respiratory medicine 20041001

• Dimethyl sulfoxide and ebselen prevent convulsions induced by 5-aminolevulinic acid.

  Neurochemical research 20041001

• Ebselen protects Ca2+ influx blockage but does not protect glutamate uptake inhibition caused by Hg2+.

  Neurochemical research 20041001

• Azoles as Suzuki cross-coupling leaving groups: syntheses of 6-arylpurine 2'-deoxynucleosides and nucleosides from 6-(imidazol-1-yl)- and 6-(1,2,4-triazol-4-yl)purine derivatives.

  Organic letters 20040916

• Nitration and functional loss of voltage-gated K+ channels in rat coronary microvessels exposed to high glucose.

  Diabetes 20040901

• Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen.

  Journal of the American Society of Nephrology : JASN 20040901

• The involvement of oxidative stress in bovine herpesvirus type 4-mediated apoptosis.

  Frontiers in bioscience : a journal and virtual library 20040901

• Protection by flavonoids against the peroxynitrite-mediated oxidation of dihydrorhodamine.

  Free radical research 20040901

• Interplay among platelet-activating factor, oxidative stress, and group I metabotropic glutamate receptors modulates neuronal survival.

  Journal of neuroscience research 20040815

• Organochalcogens affect the glutamatergic neurotransmission in human platelets.

  Neurochemical research 20040801

• Quantitation of lanosterol and its major metabolite FF-MAS in an inhibition assay of CYP51 by azoles with atmospheric pressure photoionization based LC-MS/MS.

  Journal of the American Society for Mass Spectrometry 20040801

• Voriconazole: therapeutic review of a new azole antifungal.

  Expert review of anti-infective therapy 20040801

• Comparative assessment of the inhibition of recombinant human CYP19 (aromatase) by azoles used in agriculture and as drugs for humans.

  Endocrine research 20040801

• Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity.

  The Journal of biological chemistry 20040723

• Reaction of bromomethylazoles and tosylmethyl isocyanide. A novel heterocyclization method for the synthesis of the core of marine alkaloids variolins and related azolopyrimidines.

  The Journal of organic chemistry 20040723

• Thiocyanate catalyzes myeloperoxidase-initiated lipid oxidation in LDL.

  Free radical biology & medicine 20040715

• Transforming growth factor Beta1 induction of tissue inhibitor of metalloproteinases 3 in articular chondrocytes is mediated by reactive oxygen species.

  Free radical biology & medicine 20040715

• Single-dose ebselen does not afford sustained neuroprotection to rats subjected to severe focal cerebral ischemia.

  European journal of pharmacology 20040708

• Proliferation of ovarian theca-interstitial cells is modulated by antioxidants and oxidative stress.

  Human reproduction (Oxford, England) 20040701

• Ebselen decreases oxygen free radical production and iron concentrations in the hearts of chronically iron-overloaded mice.

  Biological research for nursing 20040701

• Synthesis and fungicidal activity of enantiomerically pure (R)- and (S)-silicon-containing azole fungicides.

  Bioorganic & medicinal chemistry 20040701

• Substitution of threonine-1351 in the multidrug transporter Cdr1p of Candida albicans results in hypersusceptibility to antifungal agents and threonine-1351 is essential for synergic effects of calcineurin inhibitor FK520.

  The Journal of antimicrobial chemotherapy 20040701

• The effect of ebselen on adenine nucleotide hydrolysis by platelets from adult rats.

  Chemico-biological interactions 20040630

• Application of real-time quantitative PCR to molecular analysis of Candida albicans strains exhibiting reduced susceptibility to azoles.

  Antimicrobial agents and chemotherapy 20040601

• [Oxidative stress in a model for experimental diabetic retinopathy: treatment with antioxidants].

  Archivos de la Sociedad Espanola de Oftalmologia 20040601

• Usage of antifungal drugs for therapy of genital Candida infections, purchased as over-the-counter products or by prescription: 2. Factors that may have influenced the marked changes in sales volumes during the 1990s.

  Infectious diseases in obstetrics and gynecology 20040601

• [Analysis of the mechanism of anti-mycotic activities by azoles potentiated by new erythromycin derivatives].

  The Japanese journal of antibiotics 20040601

• Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration.

  Circulation research 20040514

• Optically active antifungal azoles: synthesis and antifungal activity of (2R,3S)-2-(2,4-difluorophenyl)-3-(5-[2-[4-aryl-piperazin-1-yl]-ethyl]-tetrazol-2-yl/1-yl)-1-[1,2,4]-triazol-1-yl-butan-2-ol.

  Bioorganic & medicinal chemistry 20040501

• Synthesis of [75Se]5-ethoxycarbonyl-4-methyl-1,2,3-selenadiazole.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20040501

• Differential effects of the combination of caspofungin and terbinafine against Candida albicans, Candida dubliniensis and Candida kefyr.

  International journal of antimicrobial agents 20040501

• Chemoenzymatic preparation of nucleoside triphosphates.

  Current protocols in nucleic acid chemistry 20040501

• Antifungal therapy for keratomycoses.

  Expert opinion on pharmacotherapy 20040401

• Axial ligand complexes of the Rhodnius nitrophorins: reduction potentials, binding constants, EPR spectra, and structures of the 4-iodopyrazole and imidazole complexes of NP4.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20040301

• History of the development of azole derivatives.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20040301

• Antifungal prophylaxis with azole derivatives.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20040301

• Clinical significance of breakthrough fungemia caused by azole-resistant Candida tropicalis in patients with hematologic malignancies.

  Haematologica 20040301

• Newer antifungal agents.

  Indian journal of pediatrics 20040301

• [Usefulness of the E-test and its assay conditions in the study of the interaction of antifungal agents. A pilot study].

  Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20040301

• Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen.

  Circulation research 20040220

• Ebselen inhibits p38 mitogen-activated protein kinase-mediated endothelial cell death by hydrogen peroxide.

  European journal of pharmacology 20040206

• Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma.

  Circulation 20040203

• Additive pro-oxidative effects of methylmercury and ebselen in liver from suckling rat pups.

  Toxicology letters 20040202

• Drug resistance genes and trailing growth in Candida albicans isolates.

  The Journal of antimicrobial chemotherapy 20040201

• Ebselen is a dehydroascorbate reductase mimic, facilitating the recycling of ascorbate via mammalian thioredoxin systems.

  Antioxidants & redox signaling 20040201

• Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding.

  Antimicrobial agents and chemotherapy 20040201

• A new era of antifungal therapy.

  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20040201

• Ebselen-mediated protection from single and repeated noise exposure in rat.

  The Laryngoscope 20040201

• (-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors.

  The Journal of pharmacy and pharmacology 20040201

• Simultaneous analysis of esterase and transferase activities in cytosol proteins from the bovine retina by using microscale non-denaturing two-dimensional electrophoresis.

  Biochimica et biophysica acta 20040114

• Renal and hepatic ALA-D activity and selected oxidative stress parameters of rats exposed to inorganic mercury and organoselenium compounds.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040101

• [Drug discovery in the new era: exploratory research on novel antifungal agents].

  Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20040101

• In vitro evaluation of glutathione peroxidase (GPx)-like activity and antioxidant properties of some Ebselen analogues.

  Redox report : communications in free radical research 20040101

• [Activity of the azole drugs in vitro against strains of Candida albicans with different codes isolated from the digestive tract in children].

  Wiadomosci parazytologiczne 20040101

• A novel series of complexones with bis- or biazole structure as mixed ligands of paramagnetic contrast agents for MRI.

  Bioorganic & medicinal chemistry 20031201

• Synthesis and biological evaluation of ebselen and its acyclic derivatives.

  Chemical & pharmaceutical bulletin 20031201

• Management of Candida species infections in critically ill patients.

  The Lancet. Infectious diseases 20031201

• Multiple mechanisms account for variation in base-line sensitivity to azole fungicides in field isolates of Mycosphaerella graminicola.

  Pest management science 20031201

• Ebselen inhibits NO-induced apoptosis of differentiated PC12 cells via inhibition of ASK1-p38 MAPK-p53 and JNK signaling and activation of p44/42 MAPK and Bcl-2.

  Journal of neurochemistry 20031201

• The C2-like beta-barrel domain mediates the Ca2+-dependent resistance of 5-lipoxygenase activity against inhibition by glutathione peroxidase-1.

  The Journal of biological chemistry 20031031

• Ebselen protects against methylmercury-induced inhibition of glutamate uptake by cortical slices from adult mice.

  Toxicology letters 20031015

• Cobalt-catalyzed arylation of azole heteroarenes via direct C-H bond functionalization.

  Organic letters 20031002

• Organochalcogens effects on delta-aminolevulinate dehydratase activity from human erythrocytic cells in vitro.

  Toxicology 20030930

• Reactive oxygen species sensitivity of angiotensin II-dependent translation initiation in vascular smooth muscle cells.

  The Journal of biological chemistry 20030919

• Generation and function of reactive oxygen species in dendritic cells during antigen presentation.

  Journal of immunology (Baltimore, Md. : 1950) 20030915

• Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae.

  The Journal of biological chemistry 20030912

• Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase.

  Bioorganic & medicinal chemistry 20030901

• Differential modulation of hippocampal chemical-induced injury response by ebselen, pentoxifylline, and TNFalpha-, IL-1alpha-, and IL-6-neutralizing antibodies.

  Journal of neuroscience research 20030815

• T cell receptor-stimulated generation of hydrogen peroxide inhibits MEK-ERK activation and lck serine phosphorylation.

  Free radical biology & medicine 20030815

• Kinetic study of azole-bridged dinuclear platinum(II) complexes reacting with a hairpin-stabilized double-stranded oligonucleotide.

  Journal of inorganic biochemistry 20030801

• Neuroprotective effect of ebselen on rat hippocampal slices submitted to oxygen-glucose deprivation: correlation with immunocontent of inducible nitric oxide synthase.

  Neuroscience letters 20030731

• Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties.

  Bioorganic & medicinal chemistry letters 20030721

• Ipso- or cine-substitutions of 6-haloimidazo[1,2-a]pyridine derivatives with different azoles depending on the reaction conditions.

  The Journal of organic chemistry 20030711

• Ebselen attenuates cochlear damage caused by acoustic trauma.

  Hearing research 20030701

• Evaluation of different calorimetric methods to determine the glass transition temperature and molecular mobility below T(g) for amorphous drugs.

  International journal of pharmaceutics 20030618

• Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice.

  Toxicology letters 20030605

• Efficacy of caspofungin combined with amphotericin B against azole-resistant Candida albicans.

  The Journal of antimicrobial chemotherapy 20030601

• A combination chemical and enzymatic approach for the preparation of azole carboxamide nucleoside triphosphate.

  The Journal of organic chemistry 20030516

• Dual effect of ebselen on mitochondrial permeability transition.

  Biochemical pharmacology 20030515

• Selective C-arylation of free (NH)-heteroarenes via catalytic C-H bond functionalization.

  Journal of the American Chemical Society 20030507

• Preparation and pharmacological profile of 7-(alpha-azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors.

  Bioorganic & medicinal chemistry letters 20030505

• In vitro and in vivo activity of tea tree oil against azole-susceptible and -resistant human pathogenic yeasts.

  The Journal of antimicrobial chemotherapy 20030501

• High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030501

• Induction of cellular necrosis by the glutathione peroxidase mimetic ebselen.

  Journal of cellular biochemistry 20030501

• Identification of genes differentially expressed in association with reduced azole susceptibility in Saccharomyces cerevisiae.

  The Journal of antimicrobial chemotherapy 20030501

• Methylmercury increases glutamate release from brain synaptosomes and glutamate uptake by cortical slices from suckling rat pups: modulatory effect of ebselen.

  Toxicological sciences : an official journal of the Society of Toxicology 20030501

• Influence of heme and heme oxygenase-1 transfection of pulmonary microvascular endothelium on oxidant generation and cGMP.

  Experimental biology and medicine (Maywood, N.J.) 20030501

• Can the ebselen derivatives catalyze the isomerization of peroxynitrite to nitrate?

  Journal of the American Chemical Society 20030402

• Effects of anti-ecdysteroid quaternary derivatives of azole analogues of metyrapone on the post-embryonic development of the red cotton bug (Dysdercus cingulatus F).

  Pest management science 20030401

• Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition.

  Journal of the American Chemical Society 20030319

• Inhibition by ebselen on nitric oxide mediated relaxations in the rat anococcygeus muscle.

  European journal of pharmacology 20030221

• Free radical scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells.

  Mutation research 20030205

• 11beta-Hydroxysteroid dehydrogenase type 1: tissue-specific expression and reductive metabolism of some anti-insect agent azole analogues of metyrapone.

  Chemico-biological interactions 20030201

• Anti-inflammatory and antinociceptive activity of diphenyl diselenide.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20030201

• [Antifungal drug].

  Nihon rinsho. Japanese journal of clinical medicine 20030201

• Redox catalysts as sensitisers towards oxidative stress.

  FEBS letters 20030130

• Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.

  Journal of medicinal chemistry 20030116

• Antifungal drug resistance.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030115

• Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia.

  Free radical biology & medicine 20030101

• Phenotyping of Cryptococcus neoformans strains in Bergamo, Italy (1985-2000).

  The new microbiologica 20030101

• Synthesis and antifungal activity of new 1-halogenobenzyl-3-imidazolylmethylindole derivatives.

  European journal of medicinal chemistry 20030101

• [Attack point of ergosterol biosynthesis. Drugs and pharmacology].

  Pharmazie in unserer Zeit 20030101

• Microbial natural products as a source of antifungals.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20030101

• [Azole resistance in Candida spp].

  Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20030101

• Voltage-dependent ebselen and diorganochalcogenides inhibition of 45Ca2+ influx into brain synaptosomes.

  Journal of biochemical and molecular toxicology 20030101

• [Cytochrome P450 3A4 and Benzodiazepines].

  Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 20030101

• [New systemic antifungal drugs: mechanisms of action, drug interactions and side effects].

  Mycoses 20030101

• [Effect of azole derivatives on lucigenin-dependent microsome chemiluminescence].

  Biomeditsinskaia khimiia 20030101

• Synthesis of silicon-containing azole derivatives with magnesium bromide diethyl etherate, and an investigation of their fungicidal activities.

  Bioorganic & medicinal chemistry 20021201

• [Clinical relevance of mechanisms of antifungal drug resistance in filamentous fungi].

  Enfermedades infecciosas y microbiologia clinica 20021201

• Inhibitory effects of 1,3-selenazol-4-one derivatives on mushroom tyrosinase.

  Chemical & pharmaceutical bulletin 20021201

• Protective effect of ebselen, a seleno-organic compound, against the progression of acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats.

  Japanese journal of pharmacology 20021201

• Deeply invasive candidiasis.

  Infectious disease clinics of North America 20021201

• [Present status and future prospects of azole antifungal agents in Japan].

  The Japanese journal of antibiotics 20021201

• Tin-free radical sequences under acidic conditions. Convergent access to azole-containing structures.

  Organic letters 20021128

• Synthesis of N-cycloalkenylazoles.

  The Journal of organic chemistry 20021115

• Synthetic applications of azolium ylides to a traceless solid-phase synthesis of 2-substituted azoles.

  Organic letters 20021114

• Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation.

  Antimicrobial agents and chemotherapy 20021101

• Clinical relevance of mechanisms of antifungal drug resistance in yeasts.

  Enfermedades infecciosas y microbiologia clinica 20021101

• A novel antioxidant mechanism of ebselen involving ebselen diselenide, a substrate of mammalian thioredoxin and thioredoxin reductase.

  The Journal of biological chemistry 20021018

• Has antifungal susceptibility testing come of age?

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021015

• Synthesis of novel water soluble benzylazolium prodrugs of lipophilic azole antifungals.

  Bioorganic & medicinal chemistry letters 20021007

• Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signalling.

  Molecular microbiology 20021001

• Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes.

  Microbiology (Reading, England) 20021001

• The neuroprotectant ebselen inhibits oxidative DNA damage induced by dopamine in the presence of copper ions.

  Neuroscience letters 20020913

• Intrahippocampal infusion of ebselen impairs retention of an inhibitory avoidance task in rats.

  European journal of pharmacology 20020913

• Treatment of azole-resistant oropharyngeal candidiasis with topical amphotericin B.

  The Annals of pharmacotherapy 20020901

• Antifungal drug resistance to azoles and polyenes.

  The Lancet. Infectious diseases 20020901

• Role of oxygen and nitrogen species in experimental uveitis: anti-inflammatory activity of the synthetic antioxidant ebselen.

  Free radical biology & medicine 20020901

• Tolerability, safety and efficacy of conventional amphotericin B administered by 24-hour infusion to lung transplant recipients.

  Swiss medical weekly 20020810

• Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells.

  British journal of pharmacology 20020801

• Effects of C-nitropyrazoles and C-nitroazoles on ocular blood flow and retinal function recovery after ischemic insult.

  Acta pharmacologica Sinica 20020801

• Ebselen protects against the reduction in levels of drug-metabolizing enzymes in livers of rats with deoxycholic acid-induced liver injury.

  Pharmacology & toxicology 20020801

• Unsymmetrical 1,1'-disubstituted ferrocenes: synthesis of Co(ii), Cu(ii), Ni(ii) and Zn(ii) chelates of ferrocenyl -1-thiadiazolo-1'-tetrazole, -1-thiadiazolo-1'-triazole and -1-tetrazolo-1'-triazole with antimicrobial properties.

  Journal of enzyme inhibition and medicinal chemistry 20020801

• Effects of angiotensin II type 1 receptor antagonist, YM358, on cardiac hypertrophy and dysfunction after myocardial infarction in rats.

  Biological & pharmaceutical bulletin 20020701

• Effect of Micafungin (FK463) on Candida albicans adherence to epithelial cells.

  Chemotherapy 20020701

• Effects of antioxidants on surfactant peroxidation by stimulated human polymorphonuclear leukocytes.

  Free radical research 20020701

• Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells.

  Circulation research 20020628

• In vitro activity of caspofungin (MK-0991) against Candida albicans clinical isolates displaying different mechanisms of azole resistance.

  Journal of clinical microbiology 20020601

• Divergent pathways account for two distinct effects of amyloid beta peptides on exocytosis and Ca(2+) currents: involvement of ROS and NF-kappaB.

  Journal of neurochemistry 20020601

• Nitric oxide mediates apoptosis induction selectively in transformed fibroblasts compared to nontransformed fibroblasts.

  Carcinogenesis 20020601

• The effects of ebselen on cisplatin and diethyldithiocarbamate (DDC) cytotoxicity in rat hippocampal astrocytes.

  Toxicology letters 20020528

• Comparative toxicological assessment of a water-soluble azole administered both orally and by intravenous continuous infusion in cynomolgus monkeys.

  The Journal of toxicological sciences 20020501

• Homozygosity at the Candida albicans MTL locus associated with azole resistance.

  Microbiology (Reading, England) 20020401

• Exposure to ebselen changes glutamate uptake and release by rat brain synaptosomes.

  Neurochemical research 20020401

• Antioxidant properties of new chalcogenides against lipid peroxidation in rat brain.

  Neurochemical research 20020401

• Do azoles and chloroquine share similar mechanisms of antimalarial action?

  Trends in parasitology 20020401

• Diagnosis and treatment of invasive pulmonary aspergillosis in neutropenic patients.

  The European respiratory journal 20020401

• Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway.

  Science (New York, N.Y.) 20020329

• Ammonium chloride-promoted four-component synthesis of pyrrolo[3,4-b]pyridin-5-one.

  Journal of the American Chemical Society 20020320

• Ebselen has dehydroascorbate reductase and thioltransferase-like activities.

  Biochemical and biophysical research communications 20020301

• Ebselen suppresses late airway responses and airway inflammation in guinea pigs.

  Free radical biology & medicine 20020301

• Synthesis, characterisation and biological activity of novel 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds.

  European journal of medicinal chemistry 20020301

• Mechanism of azole antifungal activity as determined by liquid chromatographic/mass spectrometric monitoring of ergosterol biosynthesis.

  Journal of mass spectrometry : JMS 20020301

• Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat.

  Neuroscience letters 20020201

• Molecular basis of resistance to azole antifungals.

  Trends in molecular medicine 20020201

• Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences.

  The Lancet. Infectious diseases 20020201

• Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis.

  The Journal of biological chemistry 20020125

• Carbonic anhydrase activators: design of high affinity isozymes I, II, and IV activators, incorporating tri-/tetrasubstituted-pyridinium-azole moieties.

  Journal of medicinal chemistry 20020117

• Formation of active oxygen species and lipid peroxidation induced by hypochlorite.

  Archives of biochemistry and biophysics 20020115

• Analytical and semipreparative enantiomeric separation of azole antifungal agents by high-performance liquid chromatography on polysaccharide-based chiral stationary phases. Application to in vitro biological studies.

  Journal of chromatography. A 20020104

• Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology.

  Journal of medicinal chemistry 20020103

• The impact of polyene, azole, and DNA analogue antimycotics on the cell surface hydrophobicity of Candida albicans and Candida tropicalis in HIV infection.

  Mycopathologia 20020101

• Detection of human P-glycoprotein-like molecule in azole-resistant Candida albicans from HIV+ patients.

  Microbial drug resistance (Larchmont, N.Y.) 20020101

• Action of peroxidases on protein hydroperoxides.

  Redox report : communications in free radical research 20020101

• Study of the thermal behavior of azidohetarenes with differential scanning calorimetry.

  Journal of biochemical and biophysical methods 20020101

• Overview: fungal infections in the transplant patient.

  Transplant infectious disease : an official journal of the Transplantation Society 20020101

• Fungal infection in liver transplantation.

  Transplant infectious disease : an official journal of the Transplantation Society 20020101

• Synthesis of some new azoles and azines and their condensed derivatives.

  Bollettino chimico farmaceutico 20020101

• Impact of strobilurins on physiology and yield formation of wheat.

  Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen) 20020101

• A novel dicyclodextrinyl ditelluride compound with antioxidant activity.

  FEBS letters 20011102

• Oxidative and nitrosative stress in acute renal ischemia.

  American journal of physiology. Renal physiology 20011101

• Extrusion of fluorescein diacetate by multidrug-resistant Candida albicans.

  Mycoses 20011101

• Anti-oxidant ebselen causes the resolution of experimentally induced hepatic fibrosis in rats.

  Journal of gastroenterology and hepatology 20011101

• Update on antifungal agents.

  The Pediatric infectious disease journal 20011001

• Cryptococcosis in human immunodeficiency virus-negative patients in the era of effective azole therapy.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010901

• Prevalence of vaginal colonization by drug-resistant Candida species in college-age women with previous exposure to over-the-counter azole antifungals.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010901

• Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia.

  Stroke 20010901

• Optically active antifungal azoles. XII. Synthesis and antifungal activity of the water-soluble prodrugs of 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone.

  Chemical & pharmaceutical bulletin 20010901

• Carbon disulfide promoted reactions of 2-chloro-4,5-dihydro-imidazole with some N-nucleophiles.

  Chemical & pharmaceutical bulletin 20010901

• The neuroprotective agent ebselen modifies NMDA receptor function via the redox modulatory site.

  Journal of neurochemistry 20010901

• The KEX2 gene of Candida glabrata is required for cell surface integrity.

  Molecular microbiology 20010901

• Potential application of plant lipid transfer proteins for drug delivery.

  Biochemical pharmacology 20010901

• Synthesis and biological evaluation of azole derivatives, analogues of bifonazole, with a phenylisoxazolyl or phenylpyrimidinyl moiety.

  Farmaco (Societa chimica italiana : 1989) 20010901

• Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis: implications for treatment of tuberculosis.

  Biochemical pharmacology 20010615

• Mitochondrial membrane potential in density-separated trout erythrocytes exposed to oxidative stress in vitro.

  Biochimica et biophysica acta 20010601

• Comparisons of pKa and log P values of some carboxylic and phosphonic acids: synthesis and measurement.

  AAPS pharmSci 20010601

• Therapy for fungal infections in leukemia.

  Current oncology reports 20010501

• The amino acid residues affecting the activity and azole susceptibility of rat CYP51 (sterol 14-demethylase P450).

  Journal of biochemistry 20010501

• OxLDL induces macrophage gamma-GCS-HS protein expression: a role for oxLDL-associated lipid hydroperoxide in GSH synthesis.

  Journal of lipid research 20010501

• An old activity in the cytochrome P450 superfamily (CYP51) and a new story of drugs and resistance.

  Biochemical Society transactions 20010501

• Comparison of the angiotensin II type 1-receptor antagonist YM358 and the angiotensin-converting enzyme inhibitor enalapril in rats with cardiac volume overload.

  Japanese journal of pharmacology 20010501

• Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells.

  Arteriosclerosis, thrombosis, and vascular biology 20010401

• Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinases.

  Japanese journal of cancer research : Gann 20010401

• Preventive effect of ebselen on acute gastric mucosal lesion development in rats treated with compound 48/80.

  European journal of pharmacology 20010302

• The selenoorganic compound ebselen suppresses liver injury induced by Propionibacterium acnes and lipopolysaccharide in rats.

  International journal of molecular medicine 20010301

• Itraconazole-enhanced vincristine neurotoxicity in a child with acute lymphoblastic leukemia.

  Pediatric hematology and oncology 20010301

• [The activity of systemic antimycotic drug combinations].

  Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20010301

• [Molecular mechanize and clinical feature of azole-resistant Candida albicans strains and new strategy of treatment].

  The Japanese journal of antibiotics 20010301

• Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons.

  Neuroscience letters 20010223

• Ebselen prevents early alcohol-induced liver injury in rats.

  Free radical biology & medicine 20010215

• Extracts from 'Clinical evidence': Athlete's foot and fungally infected toenails.

  BMJ (Clinical research ed.) 20010203

• Effect of ketoconazole, itraconazole and fluconazole on the gastrointestinal colonization of mice by Candida albicans.

  Journal of chemotherapy (Florence, Italy) 20010201

• Antifungal and immunomodulating activities of 1,4-benzothiazine azole derivatives: review.

  Journal of chemotherapy (Florence, Italy) 20010201

• The effects of thiol compounds and ebselen on nitric oxide activity in rat aortic vascular responses.

  Journal of autonomic pharmacology 20010201

• [Metabolic interactions with statins].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20010120

• Reactive oxygen species and caspase activation mediate silica-induced apoptosis in alveolar macrophages.

  American journal of physiology. Lung cellular and molecular physiology 20010101

• The combination of oral amphotericin B with azoles prevents the emergence of resistant Candida species in neutropenic patients.

  British journal of haematology 20010101

• Clinical applicability of antifungal susceptibility testing on non-Candida albicans species in hospitalized patients.

  Diagnostic microbiology and infectious disease 20010101

• Selective inhibition of vitamin D hydroxylases in human keratinocytes.

  Steroids 20010101

• Antiviral activity of the products of cyclization of dimethyl 2-[(1-arylamino-1-arylmethylidene)hydrazono]succinate.

  European journal of medicinal chemistry 20010101

• In vitro susceptibility of 137 Candida sp. isolates from HIV positive patients to several antifungal drugs.

  Mycopathologia 20010101

• Treatment of systemic fungal infections in older patients: achieving optimal outcomes.

  Drugs & aging 20010101

• Oral colonization by Candida spp. among AIDS household contacts.

  Mycoses 20010101

• Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats.

  Carcinogenesis 20001201

• Optically active antifungal azoles. X. Synthesis and antifungal activity of N.

  Chemical & pharmaceutical bulletin 20001201

• Bactericidal and inhibitory effects of azole antifungal compounds on Mycobacterium smegmatis.

  FEMS microbiology letters 20001115

• Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors.

  Antimicrobial agents and chemotherapy 20001001

• A new class of antifungal agents. Synthesis and antimycotic activity of disubstituted N-azolylamines.

  Archiv der Pharmazie 20000901

• Efficacy of FK463, a (1,3)-beta-D-glucan synthase inhibitor, in disseminated azole-resistant candida albicans infection in mice.

  Antimicrobial agents and chemotherapy 20000601

• In vitro synergism between nyasol, an active compound isolated from Anemarrhena asphodeloides, and azole agents against Candida albicans.

  Planta medica 20000601

• Current and emerging azole antifungal agents.

  Clinical microbiology reviews 19990101

• Azole derivatives of 1,4-benzothiazine as antifungal agents.

  Bioorganic & medicinal chemistry 19980101

• Prolongation of the QT interval related to cisapride-diltiazem interaction.

  Pharmacotherapy 19980101

• Antifungal, antibacterial, antiviral and cytotoxic activity of novel thio- and seleno-azoles.

  Pharmacological research 19970901

• In vitro activity of a new pneumocandin antifungal, L-743,872, against azole-susceptible and -resistant Candida species.

  Antimicrobial agents and chemotherapy 19970701

• In vitro activity of a new pneumocandin antifungal agent, L-733,560 against azole-susceptible and -resistant Candida and Torulopsis species.

  Antimicrobial agents and chemotherapy 19951201

• Molecular actions of ebselen--an antiinflammatory antioxidant.

  General pharmacology 19951001

• Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring.

  Journal of medicinal chemistry 19950929

• Optically active antifungal azoles. IV. Synthesis and antifungal activity of (2R,3R)-3-azolyl-2-(substituted phenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanols.

  Chemical & pharmaceutical bulletin 19950301

• Optically active antifungal azoles. V. Synthesis and antifungal activity of stereoisomers of 3-azolyl-2-(substituted phenyl)-1-(1H-1,2,4-triazol-1-yl)-2- butanols.

  Chemical & pharmaceutical bulletin 19950301

• Interaction of ebselen with glutathione S-transferase and papain in vitro.

  Biochemical pharmacology 19940315

• PZ-51 (Ebselen) in vivo protection against adriamycin-induced mouse cardiac and hepatic lipid peroxidation and toxicity.

  Biochemical pharmacology 19920818

• Plant sterol biosynthesis: novel potent and selective inhibitors of cytochrome P450-dependent obtusifoliol 14 alpha-methyl demethylase.

  Archives of biochemistry and biophysics 19920815

• In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin.

  Antimicrobial agents and chemotherapy 19920801

• Positive interaction of nikkomycins and azoles against Candida albicans in vitro and in vivo.

  Antimicrobial agents and chemotherapy 19920601

• Saperconazole: in vitro and in vivo anticandidal activity.

  Chemotherapy 19920101

• Comparison of SCH 39304 and its isomers, RR 42427 and SS 42426, for treatment of murine cryptococcal and coccidioidal meningitis.

  Antimicrobial agents and chemotherapy 19920101

• Effects of the seleno-organic substance Ebselen in two different models of acute pancreatitis.

  Pancreas 19910501

• Hypotensive action of DuP 753, an angiotensin II antagonist, in spontaneously hypertensive rats. Nonpeptide angiotensin II receptor antagonists: X.

  Hypertension (Dallas, Tex. : 1979) 19900501

• Increased external carotid artery blood flow in headache patients induced by cilostazol. Preliminary communication.

  Arzneimittel-Forschung 19900501

• Two distinct angiotensin II receptor binding sites in rat adrenal revealed by new selective nonpeptide ligands.

  Molecular pharmacology 19900301

• Overview of medically important antifungal azole derivatives.

  Clinical microbiology reviews 19880401

• Synthesis and oral antifungal activity of novel azolylpropanolones and related compounds.

  Journal of medicinal chemistry 19870601

• In vitro activity of ME1401, a new antifungal agent.

  Antimicrobial agents and chemotherapy 19861101

• Synthesis of tetrazole ribonucleosides and their evaluation as antiviral agents. 2. 5-Amino-1-(beta-D-ribofuranosyl)-1H-tetrazole and 5-amino-2-(beta-D-ribofuranosyl)-2H-tetrazole.

  Journal of medicinal chemistry 19760801

• Synthesis of tetrazole ribonucleosides and their evaluation as antiviral agents.

  Journal of medicinal chemistry 19760201

• Urinary calculi with methazolamide therapy.

  Documenta ophthalmologica. Advances in ophthalmology 19730221