42971-09-5 | Vinpocetine

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$16.00	$11.00
1g	95%	in stock	$25.00	$17.00
5g	95%	in stock	$47.00	$33.00
10g	95%	in stock	$73.00	$51.00
25g	95%	in stock	$175.00	$122.00
100g	95%	in stock	$657.00	$460.00

Description

• Catalog Number: AI50340
• Chemical Name: Vinpocetine
• CAS Number: 42971-09-5
• Molecular Formula: C22H26N2O2
• Molecular Weight: 350.45403999999996
• MDL Number: MFCD00211233
• SMILES: CCOC(=O)C1=C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3
• NSC Number: 760093

Computed Properties

• Complexity: 617
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• XLogP3: 4.1

Literature

• Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-κB.

  Chemico-biological interactions 20150725

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• Vinpocetine suppresses pathological vascular remodeling by inhibiting vascular smooth muscle cell proliferation and migration.

  The Journal of pharmacology and experimental therapeutics 20121101

• Vinpocetine inhibits breast cancer cells growth in vitro and in vivo.

  Apoptosis : an international journal on programmed cell death 20121001

• Various phosphodiesterase activities in different regions of the heart alter the cardiac effects of nitric oxide.

  Journal of cardiovascular pharmacology 20120901

• Early alcohol exposure disrupts visual cortex plasticity in mice.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20120801

• Nano-advantage in enhanced drug delivery with biodegradable nanoparticles: contribution of reduced clearance.

  Drug metabolism and disposition: the biological fate of chemicals 20120701

• [Comment on the paper by A. Valikovics et al. 'The effect of vinpocetin on cognitive function' published in the issue 3-4 of this year].

  Ideggyogyaszati szemle 20120530

• Chemical evolution of autotaxin inhibitors.

  Chemical reviews 20120509

• The facilitating effect of prucalopride on cholinergic neurotransmission in pig gastric circular muscle is regulated by phosphodiesterase 4.

  Neuropharmacology 20120401

• [The observation on curative effect of 90 cases of sudden hearing loss].

  Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 20120401

• Chiral separation of vinpocetine using cyclodextrin-modified micellar electrokinetic chromatography.

  Chirality 20120301

• Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine.

  Current radiopharmaceuticals 20120101

• Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery.

  Journal of drug delivery 20120101

• Clinical utility of adjunctive retigabine in partial onset seizures in adults.

  Therapeutics and clinical risk management 20120101

• Psychiatric symptoms of patients with primary mitochondrial DNA disorders.

  Behavioral and brain functions : BBF 20120101

• Expression of calmodulin and myosin light chain kinase during larval settlement of the Barnacle Balanus amphitrite.

  PloS one 20120101

• Role Ca(2+) in mechanisms of the red blood cells microrheological changes.

  Advances in experimental medicine and biology 20120101

• Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Vinpocetine inhibits oligodendroglial precursor cell differentiation.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Acute administration of vinpocetine, a phosphodiesterase type 1 inhibitor, ameliorates hyperactivity in a mice model of fetal alcohol spectrum disorder.

  Drug and alcohol dependence 20111201

• cGMP Signaling, Phosphodiesterases and Major Depressive Disorder.

  Current neuropharmacology 20111201

• Effect of pentoxifylline and vinpocetine on the healing of ischemic colon anastomosis: an experimental study.

  Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 20111101

• Vinpocetine inhibits glutamate release induced by the convulsive agent 4-aminopyridine more potently than several antiepileptic drugs.

  Epilepsy research 20111001

• Influence of admixed citric acid and physiological variables on the vinpocetine release from sodium alginate compressed matrix tablets.

  Drug development and industrial pharmacy 20110801

• Enhanced oral bioavailability of vinpocetine through mechanochemical salt formation: physico-chemical characterization and in vivo studies.

  Pharmaceutical research 20110801

• Age and disease related changes in the translocator protein (TSPO) system in the human brain: positron emission tomography measurements with [11C]vinpocetine.

  NeuroImage 20110601

• Oxidative stress in a model of toxic demyelination in rat brain: the effect of piracetam and vinpocetine.

  Neurochemical research 20110601

• Regulatory mechanism of duodenal bicarbonate secretion: Roles of endogenous prostaglandins and nitric oxide.

  Pharmacology & therapeutics 20110401

• Preventive effect of piracetam and vinpocetine on hypoxia-reoxygenation induced injury in primary hippocampal culture.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110401

• [Interdisciplinary approach to vestibular system impairment].

  Ideggyogyaszati szemle 20110330

• Multidisciplinary approach on characterizing a mechanochemically activated composite of vinpocetine and crospovidone.

  Journal of pharmaceutical sciences 20110301

• Conserved expression and functions of PDE4 in rodent and human heart.

  Basic research in cardiology 20110301

• Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1.

  Hypertension (Dallas, Tex. : 1979) 20110301

• S-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Novel sugar esters proniosomes for transdermal delivery of vinpocetine: preclinical and clinical studies.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110101

• Therapeutic utility of phosphodiesterase type I inhibitors in neurological conditions.

  Frontiers in neuroscience 20110101

• Hyperbaric oxygen therapy in idiopathic sudden sensorineural hearing loss (ISSNHL) in association with combined treatment.

  Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc 20110101

• Identification of cytosolic phosphodiesterases in the erythrocyte: a possible role for PDE5.

  Medical science monitor : international medical journal of experimental and clinical research 20110101

• [The use of vinpotropile in brain ischemia].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

• Preparation and in vitro/in vivo evaluation of vinpocetine elementary osmotic pump system.

  Advances in pharmacological sciences 20110101

• Reversing brain damage in former NFL players: implications for traumatic brain injury and substance abuse rehabilitation.

  Journal of psychoactive drugs 20110101

• [Endothelium-protective effects of vinpocetine, pentoxifylline and enalapril in patients with chronic brain ischemia].

  Eksperimental'naia i klinicheskaia farmakologiia 20110101

• Role of vinpocetine in cerebrovascular diseases.

  Pharmacological reports : PR 20110101

• Red blood cell aggregation changes are depended on its initial value: Effect of long-term drug treatment and short-term cell incubation with drug.

  Clinical hemorheology and microcirculation 20110101

• Effect of five common anticonvulsant drugs on naloxone-precipitated morphine withdrawal in mice.

  Research in pharmaceutical sciences 20110101

• In situ formation of nanocrystals from a self-microemulsifying drug delivery system to enhance oral bioavailability of fenofibrate.

  International journal of nanomedicine 20110101

• Pentoxifylline sensitizes human cervical tumor cells to cisplatin-induced apoptosis by suppressing NF-kappa B and decreased cell senescence.

  BMC cancer 20110101

• Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.

  Journal of biomedical science 20110101

• Omeprazole does not change the oral bioavailability or pharmacokinetics of vinpocetine in rats.

  Pharmacological reports : PR 20110101

• Macro- and microrheological parameters of blood in patients with cerebral and peripheral atherosclerosis: the molecular change mechanisms after pentoxifylline treatment.

  Clinical hemorheology and microcirculation 20110101

• Fabrication, appraisal, and transdermal permeation of sildenafil citrate-loaded nanostructured lipid carriers versus solid lipid nanoparticles.

  International journal of nanomedicine 20110101

• [Potentials of the neuroprotective treatment of polymodal action in acute and early rehabilitation period of stroke].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

• Separation of vinca alkaloid enantiomers by capillary electrophoresis applying cyclodextrin derivatives and characterization of cyclodextrin complexes by nuclear magnetic resonance spectroscopy.

  Journal of pharmaceutical and biomedical analysis 20101215

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Preparation and characterization of vinpocetine loaded nanostructured lipid carriers (NLC) for improved oral bioavailability.

  International journal of pharmaceutics 20100715

• Determination of vinpocetine and its primary metabolite, apovincaminic acid, in rat plasma by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100715

• Antinociceptive effect of vinpocetine--a comprehensive survey.

  Ideggyogyaszati szemle 20100530

• Phosphodiesterase type 1 inhibition improves learning in rats exposed to alcohol during the third trimester equivalent of human gestation.

  Neuroscience letters 20100412

• Recent advances in adjunctive therapy for epilepsy: focus on sodium channel blockers as third-generation antiepileptic drugs.

  Drugs of today (Barcelona, Spain : 1998) 20100401

• Prostaglandin EP receptor subtypes involved in regulating HCO(3)(-) secretion from gastroduodenal mucosa.

  Current pharmaceutical design 20100101

• Effects of rolipram on U46619-induced contraction and cyclic nucleotide content in the porcine coronary artery.

  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20100101

• [Possibilities of preventive treatment of Alzheimer's disease: results of the 3-year open prospective comparative study on efficacy and safety of the course therapy with cerebrolysin and cavinton in elderly patients with the syndrome of mild cognitive impairment].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• Sensitization of cervix cancer cells to Adriamycin by Pentoxifylline induces an increase in apoptosis and decrease senescence.

  Molecular cancer 20100101

• [Approaches to the therapy of neurological presentations in diabetes mellitus].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• [Electrophoresis of vasoactive drugs in the treatment and rehabilitation of patients with cerebral ischemic diseases].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• Crosstalk between adenylyl cyclase signaling pathway and Ca2+ regulatory mechanism under red blood cell microrheological changes.

  Clinical hemorheology and microcirculation 20100101

• [Chronic disorders of cerebral blood circulation: possibilities of the use of cavinton].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• Solid State Characterization of Domperidone: Hydroxypropyl-β-Cyclodextrin Inclusion Complex.

  Indian journal of pharmaceutical sciences 20100101

• Recent advances in management of bladder overactivity.

  F1000 medicine reports 20100101

• Preparation and in vitro/in vivo characterization of porous sublingual tablets containing ternary kneaded solid system of vinpocetine with î-cyclodextrin and hydroxy Acid.

  Scientia pharmaceutica 20100101

• [Efficacy of vinpotropile in the therapy of initial signs of cerebrovascular pathology].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• [Vinpotropil in the treatment of dyscirculatory encephalopathy with cognitive impairment without dementia].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• [Efficacy of cavinton in the treatment of patients with chronic blood flow insufficiency. Russian multicenter clinical-epidemiological program 'CALIPSO'].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• [Polymorphic effects of cavinton: experimental and clinical evidence].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• [The use of cavinton and cerebrolusin in the preventive therapy of Alzheimer's disease].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• Optimized preparation of vinpocetine proliposomes by a novel method and in vivo evaluation of its pharmacokinetics in New Zealand rabbits.

  Journal of controlled release : official journal of the Controlled Release Society 20091116

• A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel.

  Analytical biochemistry 20091101

• Calcium-dependent phosphodiesterase 1C inhibits renin release from isolated juxtaglomerular cells.

  American journal of physiology. Regulatory, integrative and comparative physiology 20091101

• Effects of various selective phosphodiesterase inhibitors on relaxation and cyclic nucleotide contents in porcine iris sphincter.

  The Journal of veterinary medical science 20091101

• The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue.

  European journal of pharmacology 20091012

• Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine -- a PDE1 inhibitor.

  European journal of pharmacology 20091012

• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

  Nature chemical biology 20091001

• [Significance of phosphodiesterase isoenzymes in the control of human detrusor smooth muscle function. An immunohistochemical and functional study].

  Der Urologe. Ausg. A 20090701

• Effects of phosphodiesterase inhibitors on contraction induced by endothelin-1 of isolated human prostatic tissue.

  Urology 20090601

• Comparison of self-microemulsifying drug delivery system versus solid dispersion technology used in the improvement of dissolution rate and bioavailability of vinpocetine.

  Yao xue xue bao = Acta pharmaceutica Sinica 20090601

• Preparation and evaluation of self-microemulsifying drug delivery system containing vinpocetine.

  Drug development and industrial pharmacy 20090501

• Characterization of phosphodiesterase 1 in human malignant melanoma cell lines.

  Anticancer research 20090401

• Characterization of phenytoin, carbamazepine, vinpocetine and clorgyline simultaneous effects on sodium channels and catecholamine metabolism in rat striatal nerve endings.

  Neurochemical research 20090301

• Effect of parenteral or oral vinpocetine on the hemorheological parameters of patients with chronic cerebrovascular diseases.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20090301

• Effects of phosphodiesterase inhibitors on the contractile responses of isolated human seminal vesicle tissue to adrenergic stimulation.

  The journal of sexual medicine 20090201

• Selective phosphodiesterase inhibitors: a promising target for cognition enhancement.

  Psychopharmacology 20090101

• A novel PDE2A reporter cell line: characterization of the cellular activity of PDE inhibitors.

  Molecular pharmaceutics 20090101

• Examination of a pre-exercise, high energy supplement on exercise performance.

  Journal of the International Society of Sports Nutrition 20090101

• [Efficacy of dynamic magnetic therapy in the complex treatment of cognitive disturbances in patients with chronic cerebrovascular insufficiency].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

• Neuroprotective effects of vinpocetine and its major metabolite cis-apovincaminic acid on NMDA-induced neurotoxicity in a rat entorhinal cortex lesion model.

  CNS neuroscience & therapeutics 20090101

• Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity.

  Molecular systems biology 20090101

• Phosphodiesterase inhibition increases CREB phosphorylation and restores orientation selectivity in a model of fetal alcohol spectrum disorders.

  PloS one 20090101

• [Effect of cavinton forte on the cerebral hemodynamic and autoregulation mechanisms of cerebral blood flow in patients with chronic cerebral ischemia].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

• [Cavinton in the complex treatment of patients with chronic cerebrovascular insufficiency].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

• [A multicenter program on assessment of efficacy and safety of a new therapeutic scheme for patients with chronic cerebrovascular insufficiency].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

• [Selective trabeculoplasty in combination with vasoactive agents in the complex treatment of primary open-angle glaucoma].

  Vestnik oftalmologii 20090101

• [Membrane and functional effects of vinpocetine and tocopherol in rats with experimental cerebral ischemia].

  Biomeditsinskaia khimiia 20090101

• [Cavinton in the treatment of cochleovestibular disorders of vascular genesis].

  Vestnik otorinolaringologii 20090101

• [The new scheme of cavinton application to the treatment of chronic neurosensory loss of hearing].

  Vestnik otorinolaringologii 20090101

• [The use of cavinton in the therapy of cognitive disorders in patients with discirculatory encephalopathy].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

• [Positron-emission tomography in the diagnosis of middle cerebral artery lesions].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

• Effects of Vinpocetine on mitochondrial function and neuroprotection in primary cortical neurons.

  Neurochemistry international 20081201

• Development and validation of an adsorptive stripping voltammetric method for the quantification of vincamine in its formulations and human serum using a Nujol-based carbon paste electrode.

  Chemical & pharmaceutical bulletin 20081201

• ABCD of the phosphodiesterase family: interaction and differential activity in COPD.

  International journal of chronic obstructive pulmonary disease 20081201

• Comparison of acute, chronic and post-treatment effects of carbamazepine and vinpocetine on hearing loss and seizures induced by 4-aminopyridine.

  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20081101

• Neuropharmacology.

  Indian journal of pharmacology 20081001

• Phosphodiesterase isozymes involved in regulation of formula secretion in isolated mouse stomach in vitro.

  The Journal of pharmacology and experimental therapeutics 20080901

• Muscarinic receptor M1 and phosphodiesterase 1 are key determinants in pulmonary vascular dysfunction following perinatal hypoxia in mice.

  American journal of physiology. Lung cellular and molecular physiology 20080701

• Bi-layered self-emulsifying pellets prepared by co-extrusion and spheronization: influence of formulation variables and preliminary study on the in vivo absorption.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080601

• Optimized preparation of in situ forming microparticles for the parenteral delivery of vinpocetine.

  Chemical & pharmaceutical bulletin 20080601

• Reversal of tolerance to nitroglycerin with vinpocetine: a role of calcitonin gene-related peptide.

  International journal of cardiology 20080425

• Molecular pharmacology of adipocyte-secreted autotaxin.

  Chemico-biological interactions 20080327

• Percutaneous permeation enhancement by terpenes: mechanistic view.

  The AAPS journal 20080301

• Synthesis and evaluation of 2'-hydroxyethyl trans-apovincaminate derivatives as antioxidant and cognitive enhancer agents.

  Journal of medicinal chemistry 20080214

• Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.

  Journal of medicinal chemistry 20080124

• Vinpocetine for acute ischaemic stroke.

  The Cochrane database of systematic reviews 20080123

• Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patients.

  Journal of the neurological sciences 20080115

• Changes at the focus of experimental ischemic stroke treated with neuroprotective agents.

  Neuroscience and behavioral physiology 20080101

• Self-microemulsifying drug delivery system (SMEDDS) of vinpocetine: formulation development and in vivo assessment.

  Biological & pharmaceutical bulletin 20080101

• Mitigation of nociception via transganglionic degenerative atrophy: possible mechanism of vinpocetine-induced blockade of retrograde axoplasmic transport.

  Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 20080101

• [Diagnostics and treatment tactics for chronic cerebrovascular disorders with the use of single photon emission computed tomography].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• Multimodal therapy for chronic tinnitus.

  The international tinnitus journal 20080101

• [The use of vinpotropile in chronic brain ishemia].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• In vitro antioxidant properties of pentoxifylline and vinpocetine in a rheological model.

  Clinical hemorheology and microcirculation 20080101

• [Effect of vasoactive drugs on visual functions and ocular hemodynamics in patients with primary open-angle glaucoma].

  Vestnik oftalmologii 20080101

• [Cavinton administration in hypertensive encephalopathy].

  Terapevticheskii arkhiv 20080101

• [The results of clinical study of cavinton efficacy inpatients with chronic brain ischemia].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• Development and Validation of RP-HPLC Method for Simultaneous Estimation of Atorvastatin Calcium and Fenofibrate in Tablet Dosage Forms.

  Indian journal of pharmaceutical sciences 20080101

• Effects of carbamazepine, phenytoin, valproic acid, oxcarbazepine, lamotrigine, topiramate and vinpocetine on the presynaptic Ca2+ channel-mediated release of [3H]glutamate: comparison with the Na+ channel-mediated release.

  Neuropharmacology 20071201

• Vinpocetine ameliorates acute hepatic damage caused by administration of carbon tetrachloride in rats.

  Acta biologica Hungarica 20071201

• Phosphodiesterase isozymes involved in regulation of HCO3- secretion in isolated mouse duodenum in vitro.

  Biochemical pharmacology 20071115

• Application of a novel approach to prepare biodegradable polylactic-co-glycolic acid microspheres: surface liquid spraying.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20071101

• Characterization of inhibitors of phosphodiesterase 1C on a human cellular system.

  The FEBS journal 20070901

• Cyclodextrin multicomponent complexation and controlled release delivery strategies to optimize the oral bioavailability of vinpocetine.

  Journal of pharmaceutical sciences 20070801

• In vitro and in vivo studies on the complexes of vinpocetine with hydroxypropyl-beta-cyclodextrin.

  Archives of pharmacal research 20070801

• [Investigation of the effect of vinpocetine on cerebral blood flow and cognitive functions].

  Ideggyogyaszati szemle 20070730

• [The role of vinpocetine in the treatment of cerebrovascular diseases based in human studies].

  Orvosi hetilap 20070722

• Functional responses of isolated human seminal vesicle tissue to selective phosphodiesterase inhibitors.

  Urology 20070701

• Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation.

  Neuroscience letters 20070517

• Exogenous nitric oxide stimulated collagen type I expression and TGF-beta1 production in keloid fibroblasts by a cGMP-dependent manner.

  Nitric oxide : biology and chemistry 20070301

• Effects of carbamazepine, phenytoin, lamotrigine, oxcarbazepine, topiramate and vinpocetine on Na+ channel-mediated release of [3H]glutamate in hippocampal nerve endings.

  Neuropharmacology 20070201

• Acute and chronic effects of carbamazepine, phenytoin, valproate and vinpocetine on BAEP parameters and threshold in the guinea pig.

  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20070201

• [About cavinton therapy of the patients with brain vascular diseases].

  Voenno-meditsinskii zhurnal 20070201

• Inhibitory effects of different antioxidants on hyaluronan depolymerization.

  Carbohydrate research 20070115

• Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity.

  Journal of applied toxicology : JAT 20070101

• In vivo selective binding of (R)-[11C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues.

  Nuclear medicine and biology 20070101

• Effect of vinpocetine on retrograde axoplasmic transport.

  Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 20070101

• Hemorheological efficiency of drugs, targeting on intracellular phosphodiesterase activity: in vitro study.

  Clinical hemorheology and microcirculation 20070101

• [Effect of vasoactive agents on visual functions and ocular blood flow in patients with early manifestations of age-related macular degeneration].

  Vestnik oftalmologii 20070101

• [Pharmacophysiotherapy in combined treatment of neurosensory hypoacusis in the presence of circulatory disorders in the vertebral arteries].

  Vestnik otorinolaringologii 20070101

• [The state of cerebral blood flow in hypertensive crises and possibilities of its correction].

  Kardiologiia 20070101

• [The use of the combined drug vinpotropil at early stages of cerebrovascular insufficiency].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101

• [The use of cavinton in patients with lacunar stroke developed against the background of diabetes mellitus and arterial hypertension].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101

• [Vinpotropile in the treatment of cerebral vascular diseases].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101

• [Implication of vinpotropile in the treatment of patients with cerebral stroke].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101

• Modulation of visceral nociception, inflammation and gastric mucosal injury by cinnarizine.

  Drug target insights 20070101

• [Retrospective analysis of the effect of vinpocetine infusion in ophthalmologic disorders].

  Orvosi hetilap 20061210

• Additive effects of antiepileptic drugs and pentylenetetrazole on hearing.

  Neuroscience letters 20061009

• Tumoral calcinosis: Clinical and biochemical aspects of a patient treated with vinpocetine.

  European journal of internal medicine 20061001

• [Plant metabolites as nootropics and cognitives].

  Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20060901

• Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability.

  Journal of controlled release : official journal of the Controlled Release Society 20060810

• Single and combined effects of carbamazepine and vinpocetine on depolarization-induced changes in Na+, Ca2+ and glutamate release in hippocampal isolated nerve endings.

  Neurochemistry international 20060701

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Inhibition of phosphodiesterase 1 augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs with acute pulmonary hypertension.

  American journal of physiology. Lung cellular and molecular physiology 20060401

• New HPLC-MS method for quantitative determination of apovincaminic acid in human plasma.

  Journal of separation science 20060201

• Determination of apovincaminic acid in human plasma by high-performance liquid chromatography using solid-phase extraction and ultraviolet detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060118

• Restoration of neuronal plasticity by a phosphodiesterase type 1 inhibitor in a model of fetal alcohol exposure.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060118

• [The safe use of cavinton forte in discirculatory encephalopathy].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

• Herbal medicine in the treatment of Alzheimer's disease.

  American journal of Alzheimer's disease and other dementias 20060101

• [Disturbances of brain metabolism in blood circulation disorders and their correction with cavinton].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

• [Effect of cavinton on the hemorheological parameters of chronic cerebrovascular patients].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

• [Cavinton forte treatment of cerebral vascular insufficiency in patients with coronary heart disease and arterial hypertension].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

• Vinpocetine and piracetam exert antinociceptive effect in visceral pain model in mice.

  Pharmacological reports : PR 20060101

• [Experimental study of the efficacy of apovincaminic acid derivative on the model of reperfusive cerebral damage].

  Eksperimental'naia i klinicheskaia farmakologiia 20060101

• Catharanthus roseus flower extract has wound-healing activity in Sprague Dawley rats.

  BMC complementary and alternative medicine 20060101

• [Changes in the focus of experimental ischemic stroke under the influence of neuroprotective drugs].

  Morfologiia (Saint Petersburg, Russia) 20060101

• [An effect of vinpocetine (cavinton) on endothelium function in patients with chronic cerebral ischemia].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

• Increase in tumor oxygenation and potentiation of radiation effects using pentoxifylline, vinpocetine and ticlopidine hydrochloride.

  Journal of radiation research 20051201

• Eburnamine derivatives and the brain.

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