43029-19-2 | 2-Amino-3-hydroxypyrazine

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$15.00	$11.00
1g	97%	in stock	$31.00	$22.00
5g	97%	in stock	$143.00	$101.00
10g	97%	in stock	$274.00	$192.00
25g	97%	in stock	$625.00	$438.00

Description

• Catalog Number: AB64320
• Chemical Name: 2-Amino-3-hydroxypyrazine
• CAS Number: 43029-19-2
• Molecular Formula: C4H5N3O
• Molecular Weight: 111.1020
• MDL Number: MFCD01646052
• SMILES: O=c1[nH]ccnc1N
• NSC Number: 263764

Computed Properties

• Complexity: 170
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 8
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• XLogP3: -1.3

Literature

• P3 optimization of functional potency, in vivo efficacy and oral bioavailability in 3-aminopyrazinone thrombin inhibitors bearing non-charged groups at the P1 position.

  Bioorganic & medicinal chemistry letters 20110301

• P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold.

  Bioorganic & medicinal chemistry letters 20050602

• Synthesis of 3-aminopyrazinone mediated by 2-pyridylthioimidate-ZnCl2 complexes. Development of an efficient route to a thrombin inhibitor.

  The Journal of organic chemistry 20031114

• Bioactivation of the 3-amino-6-chloropyrazinone ring in a thrombin inhibitor leads to novel dihydro-imidazole and imidazolidine derivatives: structures and mechanism using 13C-labels, mass spectrometry, and NMR.

  Drug metabolism and disposition: the biological fate of chemicals 20031101

• Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines.

  Journal of medicinal chemistry 20030213