4478-93-7 | Dl-sulforaphane

Packsize	Purity	Availability	Price	Discounted Price
5mg	≥90%	in stock	$53.00	$37.00
10mg	98%	in stock	$93.00	$65.00
100mg	98%	in stock	$302.00	$211.00
250mg	98%	in stock	$484.00	$339.00
1g	98%	in stock	$1,317.00	$922.00

Description

• Catalog Number: AB49109
• Chemical Name: Dl-sulforaphane
• CAS Number: 4478-93-7
• Molecular Formula: C6H11NOS2
• Molecular Weight: 177.2876
• MDL Number: MFCD00198068
• SMILES: S=C=NCCCCS(=O)C
• NSC Number: 749790

Computed Properties

• Complexity: 152
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Undefined Atom Stereocenter Count: 1
• XLogP3: 1.4

Literature

• Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules.

  Toxicology in vitro : an international journal published in association with BIBRA 20181001

• TRAIL attenuates sulforaphane-mediated Nrf2 and sustains ROS generation, leading to apoptosis of TRAIL-resistant human bladder cancer cells.

  Toxicology and applied pharmacology 20180801

• Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.

  Archives of toxicology 20180401

• 4-Methylthio-3-butenyl isothiocyanate mediates nuclear factor (erythroid-derived 2)-like 2 activation by regulating reactive oxygen species production in human esophageal epithelial cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180101

• Tussilagonone-induced Nrf2 pathway activation protects HepG2 cells from oxidative injury.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171001

• Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2H-Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Stress.

  The Journal of pharmacology and experimental therapeutics 20171001

• Nrf2 deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo.

  Toxicology 20170815

• Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway.

  Environmental toxicology 20170801

• Sulforaphene enhances radiosensitivity of hepatocellular carcinoma through suppression of the NF-κB pathway.

  Journal of biochemical and molecular toxicology 20170801

• Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease.

  Environmental health perspectives 20170801

• Sulforaphane attenuates di-N-butylphthalate-induced reproductive damage in pubertal mice: Involvement of the Nrf2-antioxidant system.

  Environmental toxicology 20170701

• In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Up-regulated Genes and Cognitive Scores in Children.

  Environmental health perspectives 20170401

• Ablation of Akt2 prevents paraquat-induced myocardial mitochondrial injury and contractile dysfunction: Role of Nrf2.

  Toxicology letters 20170305

• Sulforaphane induces differential modulation of mitochondrial biogenesis and dynamics in normal cells and tumor cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170201

• Sulforaphane-induced apoptosis in human leukemia HL-60 cells through extrinsic and intrinsic signal pathways and altering associated genes expression assayed by cDNA microarray.

  Environmental toxicology 20170101

• Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells.

  Chemico-biological interactions 20161225

• Nrf2-dependent protection against acute sodium arsenite toxicity in zebrafish.

  Toxicology and applied pharmacology 20160815

• Benzoquinone toxicity is not prevented by sulforaphane in CD-1 mouse fetal liver cells.

  Journal of applied toxicology : JAT 20160801

• Iron depletion in HCT116 cells diminishes the upregulatory effect of phenethyl isothiocyanate on heme oxygenase-1.

  Toxicology and applied pharmacology 20160415

• Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation.

  Acta pharmacologica Sinica 20160201

• Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1).

  Toxicological sciences : an official journal of the Society of Toxicology 20160101

• Phytonutrients Differentially Stimulate NAD(P)H:Quinone Oxidoreductase, Inhibit Proliferation, and Trigger Mitotic Catastrophe in Hepa1c1c7 Cells.

  Journal of medicinal food 20160101

• Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration.

  Nature communications 20160101

• Nrf2 activators as potential modulators of injury in human kidney cells.

  Toxicology reports 20160101

• Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.

  Chemical research in toxicology 20151116

• Regulation of the expression of renal drug transporters in KEAP1-knockdown human tubular cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20150801

• Neuroprotective effect of sulforaphane against methylglyoxal cytotoxicity.

  Chemical research in toxicology 20150615

• Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor.

  Journal of biochemical and molecular toxicology 20150601

• Sulforaphane protects against acetaminophen-induced hepatotoxicity.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20150601

• Resveratrol dimers, nutritional components in grape wine, are selective ROS scavengers and weak Nrf2 activators.

  Food chemistry 20150415

• Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1.

  Toxicology and applied pharmacology 20150101

• Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon.

  Clinical epigenetics 20150101

• Aldosterone activates transcription factor Nrf2 in kidney cells both in vitro and in vivo.

  Antioxidants & redox signaling 20141120

• Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line.

  Toxicology and applied pharmacology 20141115

• Modulation of cisplatin sensitivity in human ovarian carcinoma A2780 and SKOV3 cell lines by sulforaphane.

  Toxicology letters 20141104

• The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20141001

• Hepatic sulfotransferase as a nephropreventing target by suppression of the uremic toxin indoxyl sulfate accumulation in ischemic acute kidney injury.

  Toxicological sciences : an official journal of the Society of Toxicology 20140901

• Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function.

  Toxicology and applied pharmacology 20140901

• Phytochemical modulators of mitochondria: the search for chemopreventive agents and supportive therapeutics.

  Pharmaceuticals (Basel, Switzerland) 20140901

• Loss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis.

  Cell cycle (Georgetown, Tex.) 20140701

• The antioxidant effects of isorhamnetin contribute to inhibit COX-2 expression in response to inflammation: a potential role of HO-1.

  Inflammation 20140601

• Intronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoter.

  Biochimica et biophysica acta 20140601

• Repeated Nrf2 stimulation using sulforaphane protects fibroblasts from ionizing radiation.

  Toxicology and applied pharmacology 20140501

• Pau d'arco activates Nrf2-dependent gene expression via the MEK/ERK-pathway.

  The Journal of toxicological sciences 20140401

• Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.

  Journal of medicinal chemistry 20140327

• Transcriptomic responses of cancerous and noncancerous human colon cells to sulforaphane and selenium.

  Chemical research in toxicology 20140317

• Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms.

  Free radical biology & medicine 20140201

• Sub-chronic sulforaphane exposure in CD-1 pregnant mice enhances maternal NADPH quinone oxidoreductase 1 (NQO1) activity and mRNA expression of NQO1, glutathione S-transferase, and glutamate-cysteine ligase: potential implications for fetal protection against toxicant exposure.

  Reproductive toxicology (Elmsford, N.Y.) 20140101

• Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells.

  PloS one 20140101

• Sulforaphane attenuation of type 2 diabetes-induced aortic damage was associated with the upregulation of Nrf2 expression and function.

  Oxidative medicine and cellular longevity 20140101

• Inhibition of Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells by dietary sulforaphane.

  Molecular carcinogenesis 20131201

• A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways.

  Toxicology and applied pharmacology 20131101

• Calcineurin inhibitors recruit protein kinases JAK2 and JNK, TLR signaling and the UPR to activate NF-κB-mediated inflammatory responses in kidney tubular cells.

  Toxicology and applied pharmacology 20131101

• Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells.

  Pharmacological research 20131001

• The aryl hydrocarbon receptor and estrogen receptor alpha differentially modulate nuclear factor erythroid-2-related factor 2 transactivation in MCF-7 breast cancer cells.

  Toxicology and applied pharmacology 20130715

• Sulforaphane inhibits CYP1A1 activity and promotes genotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro.

  Toxicology and applied pharmacology 20130615

• Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner.

  Molecular and cellular biology 20130601

• Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease.

  Neurotoxicology 20130501

• Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2.

  Chemico-biological interactions 20130225

• Role of Nrf2 antioxidant defense in mitigating cadmium-induced oxidative stress in the olfactory system of zebrafish.

  Toxicology and applied pharmacology 20130115

• Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease.

  Antioxidants & redox signaling 20130110

• Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo.

  Toxicology and applied pharmacology 20130101

• Sulforaphane as a potential protective phytochemical against neurodegenerative diseases.

  Oxidative medicine and cellular longevity 20130101

• Chemoprevention of pancreatic cancer using solid-lipid nanoparticulate delivery of a novel aspirin, curcumin and sulforaphane drug combination regimen.

  International journal of oncology 20121201

• Interactions of sulforaphane and dimethyl sulfoxide with methyl methanesulfonate, urethane, 4-nitroquinoline-1-oxide and hydrogen peroxide in the Drosophila melanogaster wing spot test.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121201

• Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial.

  International journal of food sciences and nutrition 20121101

• Sulforaphane inhibits restenosis by suppressing inflammation and the proliferation of vascular smooth muscle cells.

  Atherosclerosis 20121101

• Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways.

  Oncology reports 20121101

• Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion.

  Molecular nutrition & food research 20121101

• Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli.

  Nutrition reviews 20121101

• A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level.

  The Journal of biological chemistry 20121019

• Sulphoraphane, a naturally occurring isothiocyanate induces apoptosis in breast cancer cells by targeting heat shock proteins.

  Biochemical and biophysical research communications 20121012

• Sulforaphane induced adipolysis via hormone sensitive lipase activation, regulated by AMPK signaling pathway.

  Biochemical and biophysical research communications 20121005

• The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor.

  Archives of toxicology 20121001

• Activation of the stress proteome as a mechanism for small molecule therapeutics.

  Human molecular genetics 20121001

• The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism.

  The Journal of nutritional biochemistry 20121001

• TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death.

  Biochimica et biophysica acta 20121001

• Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes.

  Molecular pharmaceutics 20121001

• Sulforaphane protects primary cultures of cortical neurons against injury induced by oxygen-glucose deprivation/reoxygenation via antiapoptosis.

  Neuroscience bulletin 20121001

• Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2.

  Biochemical pharmacology 20120915

• Natural sulforaphane as a functional chemopreventive agent: including a review of isolation, purification and analysis methods.

  Critical reviews in biotechnology 20120901

• Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model.

  Journal of neuroscience research 20120901

• Major differences among chemopreventive organoselenocompounds in the sustained elevation of cytoprotective genes.

  Journal of biochemical and molecular toxicology 20120901

• Isothiocyanates ameliorate the symptom of heart dysfunction and mortality in a murine AIDS model by inhibiting apoptosis in the left ventricle.

  Journal of medicinal food 20120901

• Metabolic effects of sulforaphane oral treatment in streptozotocin-diabetic rats.

  Journal of medicinal food 20120901

• NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes.

  Free radical biology & medicine 20120815

• Validation of the multiple sensor mechanism of the Keap1-Nrf2 system.

  Free radical biology & medicine 20120815

• Nrf2-ARE pathway regulates induction of Sestrin-2 expression.

  Free radical biology & medicine 20120815

• Quantitative profiling of glucosinolates by LC-MS analysis reveals several cultivars of cabbage and kale as promising sources of sulforaphane.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120815

• Characterization of products from the reaction of glucosinolate-derived isothiocyanates with cysteine and lysine derivatives formed in either model systems or broccoli sprouts.

  Journal of agricultural and food chemistry 20120808

• Influence of broccoli extract and various essential oils on performance and expression of xenobiotic- and antioxidant enzymes in broiler chickens.

  The British journal of nutrition 20120801

• Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis.

  Journal of gastroenterology 20120801

• Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging.

  The international journal of biochemistry & cell biology 20120801

• Sulforaphane, a cruciferous vegetable-derived isothiocyanate, inhibits protein synthesis in human prostate cancer cells.

  Biochimica et biophysica acta 20120801

• Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120801

• Improvement in determination of isothiocyanates using high-temperature reversed-phase HPLC.

  Journal of separation science 20120801

• Sulforaphane potentiates the efficacy of imatinib against chronic leukemia cancer stem cells through enhanced abrogation of Wnt/β-catenin function.

  Journal of agricultural and food chemistry 20120718

• Protective effect of sulforaphane against oxidative stress: recent advances.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120701

• Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine.

  Psychopharmacology 20120701

• Sulforaphane inhibits mitotic clonal expansion during adipogenesis through cell cycle arrest.

  Obesity (Silver Spring, Md.) 20120701

• Isothiocyanates inhibit psoriasis-related proinflammatory factors in human skin.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120701

• Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress by sulforaphane through the activation of Nrf2 nuclear translocation.

  Molecular medicine reports 20120701

• Effect of sulforaphane on growth inhibition in human brain malignant glioma GBM 8401 cells by means of mitochondrial- and MEK/ERK-mediated apoptosis pathway.

  Cell biochemistry and biophysics 20120701

• Protective effects of isothiocyanates on blood-CSF barrier disruption induced by oxidative stress.

  American journal of physiology. Regulatory, integrative and comparative physiology 20120701

• Cancer stem cells: potential target for bioactive food components.

  The Journal of nutritional biochemistry 20120701

• Effects of sulforophane and curcumin on oxidative stress created by acute malathion toxicity in rats.

  European review for medical and pharmacological sciences 20120701

• Characterization of the temporal induction of hepatic xenobiotic-metabolizing enzymes by glucosinolates and isothiocyanates: requirement for at least a 6 h exposure to elicit complete induction profile.

  Journal of agricultural and food chemistry 20120606

• Concurrent sulforaphane and eugenol induces differential effects on human cervical cancer cells.

  Integrative cancer therapies 20120601

• Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures.

  Neurochemistry international 20120601

• Toward an understanding of bisretinoid autofluorescence bleaching and recovery.

  Investigative ophthalmology & visual science 20120601

• Glucosinolates and isothiocyanates in health and disease.

  Trends in molecular medicine 20120601

• Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane.

  Free radical biology & medicine 20120601

• Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent.

  The Journal of biological chemistry 20120511

• Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy.

  The Journal of nutritional biochemistry 20120501

• Myrosinase hydrolysates of Brassica oleraceae L. var. italica reduce the risk of colon cancer.

  Phytotherapy research : PTR 20120501

• Molecular and life-history effects of a natural toxin on herbivorous and non-target soil arthropods.

  Ecotoxicology (London, England) 20120501

• In vivo biological activity of rocket extracts (Eruca vesicaria subsp. sativa (Miller) Thell) and sulforaphane.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501

• Reducing progoitrin and enriching glucoraphanin in Brassica napus seeds through silencing of the GSL-ALK gene family.

  Plant molecular biology 20120501

• Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma.

  BMB reports 20120501

• Sulforaphane retards the growth of UM-UC-3 xenographs, induces apoptosis, and reduces survivin in athymic mice.

  Nutrition research (New York, N.Y.) 20120501

• [Antibacterial mechanism of sulforaphane on Escherichia coli].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20120501

• Effects of phytochemicals sulforaphane on uridine diphosphate-glucuronosyltransferase expression as well as cell-cycle arrest and apoptosis in human colon cancer Caco-2 cells.

  The Chinese journal of physiology 20120430

• Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect.

  Age (Dordrecht, Netherlands) 20120401

• Anti-inflammatory potential of allyl-isothiocyanate--role of Nrf2, NF-(κ) B and microRNA-155.

  Journal of cellular and molecular medicine 20120401

• Metabolism of [6]-shogaol in mice and in cancer cells.

  Drug metabolism and disposition: the biological fate of chemicals 20120401

• Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism.

  Drug metabolism and disposition: the biological fate of chemicals 20120401

• Antibacterial effects of glucosinolate-derived hydrolysis products against enterobacteriaceae and enterococci isolated from pig ileum segments.

  Foodborne pathogens and disease 20120401

• Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress.

  The Journal of biological chemistry 20120323

• Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells.

  The Journal of biological chemistry 20120323

• Activation of the nuclear factor E2-related factor 2/antioxidant response element pathway is neuroprotective after spinal cord injury.

  Journal of neurotrauma 20120320

• PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress.

  Biochemical and biophysical research communications 20120316

• Cell signalling by reactive lipid species: new concepts and molecular mechanisms.

  The Biochemical journal 20120315

• Bioactive food components prevent carcinogenic stress via Nrf2 activation in BRCA1 deficient breast epithelial cells.

  Toxicology letters 20120307

• Synergistic anti-inflammatory effects of nobiletin and sulforaphane in lipopolysaccharide-stimulated RAW 264.7 cells.

  Journal of agricultural and food chemistry 20120307

• Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

  Cell metabolism 20120307

• Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply.

  Carcinogenesis 20120301

• Metabolism of glucosinolate-derived isothiocyanates to glutathione conjugates in generalist lepidopteran herbivores.

  Insect biochemistry and molecular biology 20120301

• Sulforaphane protects against 6-hydroxydopamine-induced cytotoxicity by increasing expression of heme oxygenase-1 in a PI3K/Akt-dependent manner.

  Molecular medicine reports 20120301

• Autophagy and cancer.

  Experimental & molecular medicine 20120227

• A synthetic chalcone as a potent inducer of glutathione biosynthesis.

  Journal of medicinal chemistry 20120209

• Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles.

  Breast cancer research and treatment 20120201

• Cyanidin does not affect sulforaphane-mediated Nrf2 induction in cultured human keratinocytes.

  The British journal of nutrition 20120201

• D,L-sulforaphane-induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc.

  Journal of cellular biochemistry 20120201

• Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120201

• Nutritional influences on epigenetics and age-related disease.

  The Proceedings of the Nutrition Society 20120201

• The dietary phase 2 protein inducer sulforaphane can normalize the kidney epigenome and improve blood pressure in hypertensive rats.

  American journal of hypertension 20120201

• Screening for natural chemoprevention agents that modify human Keap1.

  Analytical biochemistry 20120201

• Allyl isothiocyanate as a potential inducer of paraoxonase-1--studies in cultured hepatocytes and in mice.

  IUBMB life 20120201

• Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling.

  Free radical biology & medicine 20120201

• Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality.

  European journal of medicinal chemistry 20120201

• Protective effect of sulphoraphane against oxidative stress mediated toxicity induced by CuO nanoparticles in mouse embryonic fibroblasts BALB 3T3.

  The Journal of toxicological sciences 20120201

• Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome.

  Chemical research in toxicology 20120113

• Physiological and biochemical metabolism of germinating broccoli seeds and sprouts.

  Journal of agricultural and food chemistry 20120111

• 6-Benzylaminopurine delays senescence and enhances health-promoting compounds of harvested broccoli.

  Journal of agricultural and food chemistry 20120111

• Phytochemicals resveratrol and sulforaphane as potential agents for enhancing the anti-tumor activities of conventional cancer therapies.

  Current pharmaceutical biotechnology 20120101

• Apoptosis Induction in Primary Human Colorectal Cancer Cell Lines and Retarded Tumor Growth in SCID Mice by Sulforaphane.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Tumor angiogenesis as a target for dietary cancer prevention.

  Journal of oncology 20120101

• Ethnobiology and Ethnopharmacology of Lepidium meyenii (Maca), a Plant from the Peruvian Highlands.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China.

  Carcinogenesis 20120101

• Sulforaphane suppresses vascular adhesion molecule-1 expression in TNF-α-stimulated mouse vascular smooth muscle cells: involvement of the MAPK, NF-κB and AP-1 signaling pathways.

  Vascular pharmacology 20120101

• The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes.

  Journal of oncology 20120101

• Analysis of tanshinone IIA induced cellular apoptosis in leukemia cells by genome-wide expression profiling.

  BMC complementary and alternative medicine 20120101

• A new model for raf kinase inhibitory protein induced chemotherapeutic resistance.

  PloS one 20120101

• Autophagy in pancreatic cancer.

  International journal of cell biology 20120101

• Astroglial pentose phosphate pathway rates in response to high-glucose environments.

  ASN neuro 20120101

• Comparison of three tocopherol analogs as an inhibitor of production of proinflammatory mediators in macrophages.

  Journal of pharmacological sciences 20120101

• Induction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins a, C, and e.

  Frontiers in genetics 20120101

• Protein kinases and transcription factors activation in response to UV-radiation of skin: implications for carcinogenesis.

  International journal of molecular sciences 20120101

• Procyanidins from wild grape (Vitis amurensis) seeds regulate ARE-mediated enzyme expression via Nrf2 coupled with p38 and PI3K/Akt pathway in HepG2 cells.

  International journal of molecular sciences 20120101

• Impact of heat treatment on size, structure, and bioactivity of elemental selenium nanoparticles.

  International journal of nanomedicine 20120101

• L-cysteine administration attenuates pancreatic fibrosis induced by TNBS in rats by inhibiting the activation of pancreatic stellate cell.

  PloS one 20120101

• Thioredoxin glutathione reductase as a novel drug target: evidence from Schistosoma japonicum.

  PloS one 20120101

• Cancer stem cells and novel targets for antitumor strategies.

  Current pharmaceutical design 20120101

• Swainsonine activates mitochondria-mediated apoptotic pathway in human lung cancer A549 cells and retards the growth of lung cancer xenografts.

  International journal of biological sciences 20120101

• Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts.

  Cell communication and signaling : CCS 20120101

• Phytochemicals from plants to combat cardiovascular disease.

  Current medicinal chemistry 20120101

• Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors.

  Clinical epigenetics 20120101

• Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways.

  PloS one 20120101

• Inhibition of intestinal adenoma formation in APC(Min/+) mice by Riccardin D, a natural product derived from liverwort plant Dumortiera hirsuta.

  PloS one 20120101

• Protective Effect of the Fruit Hull of Gleditsia sinensis on LPS-Induced Acute Lung Injury Is Associated with Nrf2 Activation.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Chromium stress mitigation by polyamine-brassinosteroid application involves phytohormonal and physiological strategies in Raphanus sativus L.

  PloS one 20120101

• Exposure to ozone modulates human airway protease/antiprotease balance contributing to increased influenza A infection.

  PloS one 20120101

• The safety of cruciferous plants in humans: a systematic review.

  Journal of biomedicine & biotechnology 20120101

• Glutathione homeostasis and functions: potential targets for medical interventions.

  Journal of amino acids 20120101

• A versatile ΦC31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture.

  PloS one 20120101

• Epigenetic factors in cancer risk: effect of chemical carcinogens on global DNA methylation pattern in human TK6 cells.

  PloS one 20120101

• Platelet-rich plasma peptides: key for regeneration.

  International journal of peptides 20120101

• The absence of Nrf2 enhances NF-κB-dependent inflammation following scratch injury in mouse primary cultured astrocytes.

  Mediators of inflammation 20120101

• Role of serine racemase in behavioral sensitization in mice after repeated administration of methamphetamine.

  PloS one 20120101

• Sulforaphane potentiates RNA damage induced by different xenobiotics.

  PloS one 20120101

• Mechanism of chemical activation of Nrf2.

  PloS one 20120101

• Modulation of experimental herpes encephalitis-associated neurotoxicity through sulforaphane treatment.

  PloS one 20120101

• Epigenetics and breast cancers.

  Obstetrics and gynecology international 20120101

• Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat.

  PloS one 20120101

• Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2/Keap1 pathway in the developing mouse esophagus.

  PloS one 20120101

• Camel milk modulates the expression of aryl hydrocarbon receptor-regulated genes, Cyp1a1, Nqo1, and Gsta1, in murine hepatoma Hepa 1c1c7 cells.

  Journal of biomedicine & biotechnology 20120101

• Malabaricone-A induces a redox imbalance that mediates apoptosis in U937 cell line.

  PloS one 20120101

• Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells.

  PloS one 20120101

• Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention.

  International journal of nanomedicine 20120101

• Prevention of diabetic complications by activation of Nrf2: diabetic cardiomyopathy and nephropathy.

  Experimental diabetes research 20120101

• The yin and yang of nrf2-regulated selenoproteins in carcinogenesis.

  International journal of cell biology 20120101

• Alternative strategy for Alzheimer's disease: stress response triggers.

  International journal of Alzheimer's disease 20120101

• Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modifications.

  PloS one 20120101

• Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5.

  PloS one 20120101

• Anticancer activity of green tea polyphenols in prostate gland.

  Oxidative medicine and cellular longevity 20120101

• Glycerol supplementation enhances L. reuteri's protective effect against S. Typhimurium colonization in a 3-D model of colonic epithelium.

  PloS one 20120101

• Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects.

  Oxidative medicine and cellular longevity 20120101

• Mechanisms of anticancer activity of sulforaphane from Brassica oleracea in HEp-2 human epithelial carcinoma cell line.

  Asian Pacific journal of cancer prevention : APJCP 20120101

• Photothrombosis-induced infarction of the mouse cerebral cortex is not affected by the Nrf2-activator sulforaphane.

  PloS one 20120101

• Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer.

  Journal of carcinogenesis 20120101

• Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal.

  PloS one 20120101

• Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation.

  Oxidative medicine and cellular longevity 20120101

• Activating Nrf-2 signaling depresses unilateral ureteral obstruction-evoked mitochondrial stress-related autophagy, apoptosis and pyroptosis in kidney.

  PloS one 20120101

• Lipids, blood pressure, kidney - what was new in 2011?

  Archives of medical science : AMS 20111231

• Sulforaphane inhibits mitochondrial permeability transition and oxidative stress.

  Free radical biology & medicine 20111215

• Hydrogen sulfide mediates the anti-survival effect of sulforaphane on human prostate cancer cells.

  Toxicology and applied pharmacology 20111215

• Transthiocarbamoylation of proteins by thiolated isothiocyanates.

  The Journal of biological chemistry 20111209

• Cancer chemoprevention by targeting the epigenome.

  Current drug targets 20111201

• Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice.

  Pharmaceutical research 20111201

• Novel insights into the regulation of antioxidant-response-element-mediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2.

  The Biochemical journal 20111201

• Health benefits and possible risks of broccoli - an overview.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111201

• Nutritional antioxidants and adaptive cell responses: an update.

  Current molecular medicine 20111201

• GSTT1 is upregulated by oxidative stress through p38-MK2 signaling pathway in human granulosa cells: possible association with mitochondrial activity.

  Aging 20111201

• Toxicological aspects of the use of phenolic compounds in disease prevention.

  Interdisciplinary toxicology 20111201

• An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells.

  Marine drugs 20111201

• Induction of glutathione synthesis and conjugation by 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dihydroxymethamphetamine (HHMA) in human and rat liver cells, including the protective role of some antioxidants.

  Toxicology 20111118

• Sulforaphane inhibits oral carcinoma cell migration and invasion in vitro.

  Phytotherapy research : PTR 20111101

• Quinoprotein adducts accumulate in the substantia nigra of aged rats and correlate with dopamine-induced toxicity in SH-SY5Y cells.

  Neurochemical research 20111101

• Sulforaphane suppresses polycomb group protein level via a proteasome-dependent mechanism in skin cancer cells.

  Molecular pharmacology 20111101

• Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design.

  Pharmacological research 20111101

• Transcriptional modulation of the NAD(P)H:quinone oxidoreductase 1 by mercury in human hepatoma HepG2 cells.

  Free radical biology & medicine 20111101

• Glucoraphanin does not reduce plasma homocysteine in rats with sufficient Se supply via the induction of liver ARE-regulated glutathione biosynthesis enzymes.

  Food & function 20111101

• Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients.

  The Journal of clinical investigation 20111101

• Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes.

  Current neurovascular research 20111101

• Nrf2 activators as attractive therapeutics for diabetic nephropathy.

  Diabetes 20111101

• Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy.

  Diabetes 20111101

• Sulforaphane induces antioxidative and antiproliferative responses by generating reactive oxygen species in human bronchial epithelial BEAS-2B cells.

  Journal of Korean medical science 20111101

• Comparison of isothiocyanate metabolite levels and histone deacetylase activity in human subjects consuming broccoli sprouts or broccoli supplement.

  Journal of agricultural and food chemistry 20111026

• Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells.

  Clinical epigenetics 20111026

• Identification of potential protein targets of isothiocyanates by proteomics.

  Chemical research in toxicology 20111017

• Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding.

  Antioxidants & redox signaling 20111015

• Transforming growth factor-β and nuclear factor E2–related factor 2 regulate antioxidant responses in airway smooth muscle cells: role in asthma.

  American journal of respiratory and critical care medicine 20111015

• Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53.

  Toxicology in vitro : an international journal published in association with BIBRA 20111001

• Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin.

  Molecular nutrition & food research 20111001

• Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway.

  Biochimica et biophysica acta 20111001

• Impaired integrity of DNA after recovery from inflammation causes persistent dysfunction of colonic smooth muscle.

  Gastroenterology 20111001

• Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ARE pathway.

  Cancer prevention research (Philadelphia, Pa.) 20111001

• Novel function of transcription factor Nrf2 as an inhibitor of RON tyrosine kinase receptor-mediated cancer cell invasion.

  The Journal of biological chemistry 20110916

• Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds.

  The Journal of nutritional biochemistry 20110901

• Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice.

  Oncology reports 20110901

• Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.

  Disease models & mechanisms 20110901

• Protection against 2-chloroethyl ethyl sulfide (CEES)-induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway.

  Toxicology and applied pharmacology 20110901

• Transcription factor Nrf2 protects the spinal cord from inflammation produced by spinal cord injury.

  The Journal of surgical research 20110901

• Radiosensitization of head and neck cancer cells by the phytochemical agent sulforaphane.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20110901

• Pharmaconutrition for the obese, critically ill patient.

  JPEN. Journal of parenteral and enteral nutrition 20110901

• Nrf2, a PPARγ alternative pathway to promote CD36 expression on inflammatory macrophages: implication for malaria.

  PLoS pathogens 20110901

• Cruciferous vegetable phytochemical sulforaphane affects phase II enzyme expression and activity in rat cardiomyocytes through modulation of Akt signaling pathway.

  Journal of food science 20110901

• Protective effect of sulforaphane pretreatment against cisplatin-induced liver and mitochondrial oxidant damage in rats.

  Toxicology 20110815

• Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice.

  Toxicology and applied pharmacology 20110815

• LC-MS/MS quantification of sulforaphane and indole-3-carbinol metabolites in human plasma and urine after dietary intake of selenium-fortified broccoli.

  Journal of agricultural and food chemistry 20110810

• Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality.

  Archives of toxicology 20110801

• Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury.

  Environmental health perspectives 20110801

• The role of constitutive androstane receptor in oxazaphosphorine-mediated induction of drug-metabolizing enzymes in human hepatocytes.

  Pharmaceutical research 20110801

• 3,3'-Diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts.

  Free radical research 20110801

• Nrf-2 regulates cyclosporine-stimulated HO-1 expression in gingiva.

  Journal of dental research 20110801

• Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma.

  Haematologica 20110801

• Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells.

  Free radical biology & medicine 20110715

• Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells.

  Molecular nutrition & food research 20110701

• Sulforaphane protects human chondrocytes against cell death induced by various stimuli.

  Journal of cellular physiology 20110701

• Autophagy and cell death signaling following dietary sulforaphane act independently of each other and require oxidative stress in pancreatic cancer.

  International journal of oncology 20110701

• Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110701

• Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells.

  Drug and chemical toxicology 20110701

• Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates.

  Biopharmaceutics & drug disposition 20110701

• Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications.

  Annals of the New York Academy of Sciences 20110701

• The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics.

  Chemico-biological interactions 20110630

• Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.

  Journal of medicinal chemistry 20110623

• The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer.

  International journal of cancer 20110615

• Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism.

  Antioxidants & redox signaling 20110615

• Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells.

  Cancer epidemiology 20110601

• Sulforaphane inhibits de novo synthesis of IL-8 and MCP-1 in human epithelial cells generated by cigarette smoke extract.

  Journal of immunotoxicology 20110601

• Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane.

  Molecular carcinogenesis 20110601

• Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals.

  Nutrition reviews 20110601

• Phytochemical analysis and antimicrobial activity of Cardaria draba (L.) Desv. volatiles.

  Chemistry & biodiversity 20110601

• Epigallocatechin-3-gallate Regulates Inducible Nitric Oxide Synthase Expression in Human Umbilical Vein Endothelial Cells.

  Laboratory animal research 20110601

• Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29.

  Chemico-biological interactions 20110530

• 3,4-methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition.

  Toxicology letters 20110530

• Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties.

  British journal of cancer 20110510

• Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death.

  Cancer chemotherapy and pharmacology 20110501

• Sulforaphane-mediated reduction of aflatoxin B₁-N⁷-guanine in rat liver DNA: impacts of strain and sex.

  Toxicological sciences : an official journal of the Society of Toxicology 20110501

• Intrinsic and extrinsic regulation of innate immune receptors.

  Yonsei medical journal 20110501

• Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents.

  Drug metabolism reviews 20110501

• Modification of keap1 cysteine residues by sulforaphane.

  Chemical research in toxicology 20110418

• Characterization of the threshold for NAD(P)H:quinone oxidoreductase activity in intact sulforaphane-treated pulmonary arterial endothelial cells.

  Free radical biology & medicine 20110415

• Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model.

  Science translational medicine 20110413

• Role of alpha class glutathione transferases (GSTs) in chemoprevention: GSTA1 and A4 overexpressing human leukemia (HL60) cells resist sulforaphane and curcumin induced toxicity.

  Phytotherapy research : PTR 20110401

• Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage.

  Journal of neuroscience research 20110401

• Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages.

  Archives of biochemistry and biophysics 20110401

• Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways.

  Cell death & disease 20110401

• [Inhibition of glucoraphenin enzymolysis in Raphani Semen by processing].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110401

• Food: The omnivore's labyrinth.

  Nature 20110324

• Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress.

  Biochemical and biophysical research communications 20110311

• Pseudomonas sax genes overcome aliphatic isothiocyanate-mediated non-host resistance in Arabidopsis.

  Science (New York, N.Y.) 20110304

• Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin.

  Lung cancer (Amsterdam, Netherlands) 20110301

• Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China.

  Cancer prevention research (Philadelphia, Pa.) 20110301

• Heme oxygenase-1: a novel therapeutic target for gastrointestinal diseases.

  Journal of clinical biochemistry and nutrition 20110301

• Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls.

  Toxicology and applied pharmacology 20110215

• Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.

  Journal of medicinal chemistry 20110210

• Stimulation of phagocytosis by sulforaphane.

  Biochemical and biophysical research communications 20110204

• Protective role of sulforaphane against oxidative stress mediated mitochondrial dysfunction induced by benzo(a)pyrene in female Swiss albino mice.

  Pulmonary pharmacology & therapeutics 20110201

• Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells.

  Carcinogenesis 20110201

• Role of sulforaphane in the anti-initiating mechanism of lung carcinogenesis in vivo by modulating the metabolic activation and detoxification of benzo(a)pyrene.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110201

• Human CYP2A6 is regulated by nuclear factor-erythroid 2 related factor 2.

  Biochemical pharmacology 20110115

• Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate.

  Molecular therapy : the journal of the American Society of Gene Therapy 20110104

• Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes.

  Environmental health perspectives 20110101

• Involvement of caspase-9 in autophagy-mediated cell survival pathway.

  Biochimica et biophysica acta 20110101

• Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage.

  Neuropharmacology 20110101

• Dietary phenethyl isothiocyanate alters gene expression in human breast cancer cells.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Bioactive food components and cancer-specific metabonomic profiles.

  Journal of biomedicine & biotechnology 20110101

• Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells.

  Frontiers in bioscience (Elite edition) 20110101

• Selenium toxicity but not deficient or super-nutritional selenium status vastly alters the transcriptome in rodents.

  BMC genomics 20110101

• Sulforaphane absorption and excretion following ingestion of a semi-purified broccoli powder rich in glucoraphanin and broccoli sprouts in healthy men.

  Nutrition and cancer 20110101

• Molecular basis for vulnerability to mitochondrial and oxidative stress in a neuroendocrine CRI-G1 cell line.

  PloS one 20110101

• Mathematical model of uptake and metabolism of arsenic(III) in human hepatocytes - Incorporation of cellular antioxidant response and threshold-dependent behavior.

  BMC systems biology 20110101

• Prolonged sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells.

  Nutrition and cancer 20110101

• Cruciferous vegetable supplementation in a controlled diet study alters the serum peptidome in a GSTM1-genotype dependent manner.

  Nutrition journal 20110101

• Exposure to isothiocyanates suppresses urinary mutagenicity in rats treated with heterocyclic amine IQ: lack of association with CYP1 activity.

  Nutrition and cancer 20110101

• Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition.

  PloS one 20110101

• The endotoxin-induced neuroinflammation model of Parkinson's disease.

  Parkinson's disease 20110101

• Glutathione biosynthesis via activation of the nuclear factor E2-related factor 2 (Nrf2)--antioxidant-response element (ARE) pathway is essential for neuroprotective effects of sulforaphane and 6-(methylsulfinyl) hexyl isothiocyanate.

  Journal of pharmacological sciences 20110101

• The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease.

  Parkinson's disease 20110101

• Discovery of molecular mechanisms of traditional Chinese medicinal formula Si-Wu-Tang using gene expression microarray and connectivity map.

  PloS one 20110101

• Sulforaphane blocks hypoxia-mediated resistance to TRAIL-induced tumor cell death.

  Molecular medicine reports 20110101

• Drosophila models of Parkinson's disease: discovering relevant pathways and novel therapeutic strategies.

  Parkinson's disease 20110101

• Chemopreventive role of sulforaphane by upholding the GSH redox cycle in pre- and post-initiation phases of experimental lung carcinogenesis.

  Asian Pacific journal of cancer prevention : APJCP 20110101

• Stroma regulates increased epithelial lateral cell adhesion in 3D culture: a role for actin/cadherin dynamics.

  PloS one 20110101

• Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells.

  PloS one 20110101

• Sulforaphane enhances protection and repair of gastric mucosa against oxidative stress in vitro, and demonstrates anti-inflammatory effects on Helicobacter pylori-infected gastric mucosae in mice and human subjects.

  Current pharmaceutical design 20110101

• NNK-Induced Lung Tumors: A Review of Animal Model.

  Journal of oncology 20110101

• Age-related retinopathy in NRF2-deficient mice.

  PloS one 20110101

• Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.

  Molecular cancer 20110101

• Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway.

  International journal of Alzheimer's disease 20110101

• Of cabbages and kings.

  Gut microbes 20110101

• Combination treatment with 5-fluorouracil and isothiocyanates shows an antagonistic effect in Chinese hamster fibroblast cells line-V79.

  Acta poloniae pharmaceutica 20110101

• The role of blood flow in determining the sites of atherosclerotic plaques.

  F1000 medicine reports 20110101

• Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay.

  PloS one 20110101

• Separation and purification of sulforaphane from broccoli by solid phase extraction.

  International journal of molecular sciences 20110101

• Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epithelium.

  Journal of biomedical science 20110101

• Induction of G₂/M arrest and apoptosis by sulforaphane in human osteosarcoma U2-OS cells.

  Molecular medicine reports 20110101

• Inhibition of premature death by isothiocyanates through immune restoration in LP-BM5 leukemia retrovirus-infected C57BL/6 mice.

  Bioscience, biotechnology, and biochemistry 20110101

• NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease.

  PloS one 20110101

• Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system.

  Respiratory research 20110101

• Identification of NF-κB modulation capabilities within human intestinal commensal bacteria.

  Journal of biomedicine & biotechnology 20110101

• Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors.

  Journal of biomedicine & biotechnology 20110101

• Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms.

  PloS one 20110101

• Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2'-O-acetyl-α-L-rhamnosyloxy)benzyl]isothiocyanate from Moringa oleifera.

  Nutrition and cancer 20110101

• Benzyl isothiocyanate, a major component from the roots of Salvadora persica is highly active against Gram-negative bacteria.

  PloS one 20110101

• Photo-products of retinal pigment epithelial bisretinoids react with cellular thiols.

  Molecular vision 20110101

• Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species.

  PloS one 20110101

• Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function.

  Nutrition and cancer 20110101

• Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study.

  Journal of clinical bioinformatics 20110101

• Activation of Nrf2-regulated glutathione pathway genes by ischemic preconditioning.

  Oxidative medicine and cellular longevity 20110101

• Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors.

  PloS one 20110101

• Antimelanogenic effect of c-phycocyanin through modulation of tyrosinase expression by upregulation of ERK and downregulation of p38 MAPK signaling pathways.

  Journal of biomedical science 20110101

• Evidence for oxidative stress and defective antioxidant response in guinea pigs with tuberculosis.

  PloS one 20110101

• Galectin-3 and Beclin1/Atg6 genes in human cancers: using cDNA tissue panel, qRT-PCR, and logistic regression model to identify cancer cell biomarkers.

  PloS one 20110101

• Targeted deletion of Nrf2 reduces urethane-induced lung tumor development in mice.

  PloS one 20110101

• Notch activation by phenethyl isothiocyanate attenuates its inhibitory effect on prostate cancer cell migration.

  PloS one 20110101

• Tissue-restricted expression of Nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles.

  PloS one 20110101

• Shattering the underpinnings of neoplastic architecture in LNCap: synergistic potential of nutraceuticals in dampening PDGFR/EGFR signaling and cellular proliferation.

  Journal of experimental therapeutics & oncology 20110101

• Butyrate enhances disease resistance of chickens by inducing antimicrobial host defense peptide gene expression.

  PloS one 20110101

• A switch from canonical to noncanonical Wnt signaling mediates drug resistance in colon cancer cells.

  PloS one 20110101

• Development and validation of an LC-MS-MS method for the simultaneous determination of sulforaphane and its metabolites in rat plasma and its application in pharmacokinetic studies.

  Journal of chromatographic science 20110101

• Low intracellular ATP levels exacerbate carcinogen-induced inflammatory stress response and inhibit in vitro tubulogenesis in human brain endothelial cells.

  Journal of inflammation research 20110101

• New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer.

  Prostate cancer 20110101

• Adolescent idiopathic scoliosis (AIS), environment, exposome and epigenetics: a molecular perspective of postnatal normal spinal growth and the etiopathogenesis of AIS with consideration of a network approach and possible implications for medical therapy.

  Scoliosis 20110101

• Effect of Turkish propolis extracts on proteome of prostate cancer cell line.

  Proteome science 20110101

• MRI to assess chemoprevention in transgenic adenocarcinoma of mouse prostate (TRAMP).

  BMC medical imaging 20110101

• Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?

  Medical gas research 20110101

• Strategies for reducing or preventing the generation of oxidative stress.

  Oxidative medicine and cellular longevity 20110101

• Chinese herb mix Tiáo-Gēng-Tāng possesses antiaging and antioxidative effects and upregulates expression of estrogen receptors alpha and beta in ovariectomized rats.

  BMC complementary and alternative medicine 20110101

• The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia.

  PloS one 20110101

• Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells.

  Clinical epigenetics 20110101

• Compositional studies: antioxidant and antidiabetic activities of Capparis decidua (Forsk.) Edgew.

  International journal of molecular sciences 20110101

• Epigenomics of ovarian cancer and its chemoprevention.

  Frontiers in genetics 20110101

• Epigenetic Contributions to the Relationship between Cancer and Dietary Intake of Nutrients, Bioactive Food Components, and Environmental Toxicants.

  Frontiers in genetics 20110101

• Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, strain CNS284.

  Journal of medicinal chemistry 20101223

• Anti-oxidant and Anti-hypercholesterolemic Activities of Wasabia japonica.

  Evidence-based complementary and alternative medicine : eCAM 20101201

• The Chinese herbal medicine Sophora flavescens activates pregnane X receptor.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Sulforaphane modulates the expression of Cyp6a2 and Cyp6g1 in larvae of the ST and HB crosses of the Drosophila wing spot test and is genotoxic in the ST cross.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20101201

• Organosulfur compounds and cardiovascular disease.

  Molecular aspects of medicine 20101201

• Determination of new biomarkers to monitor the dietary consumption of isothiocyanates.

  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20101201

• Brain mitochondria from rats treated with sulforaphane are resistant to redox-regulated permeability transition.

  Journal of bioenergetics and biomembranes 20101201

• Anticancer activity of a broccoli derivative, sulforaphane, in barrett adenocarcinoma: potential use in chemoprevention and as adjuvant in chemotherapy.

  Translational oncology 20101201

• [Sulforaphane--a possible agent in prevention and therapy of cancer].

  Postepy higieny i medycyny doswiadczalnej (Online) 20101129

• Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27.

  The Journal of biological chemistry 20101112

• Protective effect of sulforaphane against cisplatin-induced mitochondrial alterations and impairment in the activity of NAD(P)H: quinone oxidoreductase 1 and γ glutamyl cysteine ligase: studies in mitochondria isolated from rat kidney and in LLC-PK1 cells.

  Toxicology letters 20101110

• Intact glucosinolates modulate hepatic cytochrome P450 and phase II conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables.

  Toxicology 20101109

• Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain.

  Environmental health perspectives 20101101

• Sulforaphane inhibits endothelial lipase expression through NF-κB in endothelial cells.

  Atherosclerosis 20101101

• Sulforaphane inhibits 4-aminobiphenyl-induced DNA damage in bladder cells and tissues.

  Carcinogenesis 20101101

• Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products.

  Biological chemistry 20101101

• The role of Nrf2 signaling in the regulation of antioxidants and detoxifying enzymes after traumatic brain injury in rats and mice.

  Acta pharmacologica Sinica 20101101

• Sulforaphane suppresses TARC/CCL17 and MDC/CCL22 expression through heme oxygenase-1 and NF-κB in human keratinocytes.

  Archives of pharmacal research 20101101

• Glucoraphanin hydrolysis by microbiota in the rat cecum results in sulforaphane absorption.

  Food & function 20101101

• A cautionary note on using N-acetylcysteine as an antagonist to assess isothiocyanate-induced reactive oxygen species-mediated apoptosis.

  Analytical biochemistry 20101015

• Regulation of human carbonyl reductase 3 (CBR3; SDR21C2) expression by Nrf2 in cultured cancer cells.

  Biochemistry 20101005

• Isothiocyanate sulforaphane inhibits protooncogenic ornithine decarboxylase activity in colorectal cancer cells via induction of the TGF-β/Smad signaling pathway.

  Molecular nutrition & food research 20101001

• Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway.

  Cancer letters 20100928

• Heteroaromatic 4-arylquinols are novel inducers of nuclear factor-erythroid 2-related factor 2 (Nrf2).

  European journal of pharmacology 20100925

• Mutant TAR DNA-binding protein-43 induces oxidative injury in motor neuron-like cell.

  Neuroscience 20100915

• Modular, homochiral, porous coordination polymers: rational design, enantioselective guest exchange sorption and ab initio calculations of host-guest interactions.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20100910

• Modulation of NAD(P)H:quinone oxidoreductase by vanadium in human hepatoma HepG2 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20100901

• Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response.

  Toxicology and applied pharmacology 20100901

• Hexane extract of Raphanus sativus L. roots inhibits cell proliferation and induces apoptosis in human cancer cells by modulating genes related to apoptotic pathway.

  Plant foods for human nutrition (Dordrecht, Netherlands) 20100901

• Dietary polyphenol quercetin targets pancreatic cancer stem cells.

  International journal of oncology 20100901

• The inhibition of autophagy potentiates anti-angiogenic effects of sulforaphane by inducing apoptosis.

  Angiogenesis 20100901

• Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells.

  Acta pharmacologica Sinica 20100901

• Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.

  Cancer metastasis reviews 20100901

• Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells.

  Anticancer research 20100901

• Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells.

  Anticancer research 20100901

• Independent effects of the broccoli-derived compound sulforaphane on Ca²⁺ influx and apoptosis in Madin-Darby canine renal tubular cells.

  The Chinese journal of physiology 20100831

• Sensitization of non-small cell lung cancer cells to cisplatin by naturally occurring isothiocyanates.

  Chemical research in toxicology 20100816

• Sulforaphane suppresses ultraviolet B-induced inflammation in HaCaT keratinocytes and HR-1 hairless mice.

  The Journal of nutritional biochemistry 20100801

• Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression.

  Toxicological sciences : an official journal of the Society of Toxicology 20100801

• Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells.

  The Journal of nutrition 20100801

• Induction of detoxification enzymes by feeding unblanched Brussels sprouts containing active myrosinase to mice for 2 wk.

  Journal of food science 20100801

• Sulforaphane protects brains against hypoxic-ischemic injury through induction of Nrf2-dependent phase 2 enzyme.

  Brain research 20100709

• Sulforaphane induces DNA single strand breaks in cultured human cells.

  Mutation research 20100707

• Does molecular docking reveal alternative chemopreventive mechanism of activation of oxidoreductase by sulforaphane isothiocyanates?

  Journal of molecular modeling 20100701

• Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR.

  European journal of medicinal chemistry 20100701

• Sulforaphane protects liver injury induced by intestinal ischemia reperfusion through Nrf2-ARE pathway.

  World journal of gastroenterology 20100628

• Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.

  Journal of proteomics 20100616

• Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics.

  Cancer research 20100615

• Analysis and anti-Helicobacter activity of sulforaphane and related compounds present in broccoli ( Brassica oleracea L.) sprouts.

  Journal of agricultural and food chemistry 20100609

• Sulforaphane suppresses LPS-induced inflammation in primary rat microglia.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20100601

• Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress.

  Environmental health perspectives 20100601

• The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos.

  Toxicological sciences : an official journal of the Society of Toxicology 20100601

• Regulation of neutrophil elastase-induced MUC5AC expression by nuclear factor erythroid-2 related factor 2 in human airway epithelial cells.

  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20100601

• Protective effect of sulforaphane on human vascular endothelial cells against lipopolysaccharide-induced inflammatory damage.

  Cardiovascular toxicology 20100601

• Cancer prevention with natural compounds.

  Seminars in oncology 20100601

• Inactivation of Aconitase by Tetrahydrobiopterin in DArgic Cells: Relevance to PD.

  Experimental neurobiology 20100601

• Electrophilic tuning of the chemoprotective natural product sulforaphane.

  Proceedings of the National Academy of Sciences of the United States of America 20100525

• Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis.

  Free radical biology & medicine 20100515

• Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation.

  Journal of neuroscience research 20100501

• Sulforaphane and alpha-lipoic acid upregulate the expression of the pi class of glutathione S-transferase through c-jun and Nrf2 activation.

  The Journal of nutrition 20100501

• A complex interplay of three R2R3 MYB transcription factors determines the profile of aliphatic glucosinolates in Arabidopsis.

  Plant physiology 20100501

• Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100501

• Antitumor activity and COMPARE analysis of bis-indole derivatives.

  Bioorganic & medicinal chemistry 20100501

• Identification and characterization of novel Nrf2 inducers designed to target the intervening region of Keap1.

  Chemical biology & drug design 20100501

• When food meets man: the contribution of epigenetics to health.

  Nutrients 20100501

• New biomarkers for monitoring the levels of isothiocyanates in humans.

  Chemical research in toxicology 20100419

• The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis.

  Free radical biology & medicine 20100415

• Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.

  Bioorganic & medicinal chemistry letters 20100415

• Role of lipid peroxidation in cellular responses to D,L-sulforaphane, a promising cancer chemopreventive agent.

  Biochemistry 20100413

• HPLC method validation for measurement of sulforaphane level in broccoli by-products.

  Biomedical chromatography : BMC 20100401

• Targeting NRF2 signaling for cancer chemoprevention.

  Toxicology and applied pharmacology 20100401

• Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels.

  Pharmacological research 20100401

• The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy.

  Diabetes 20100401

• Deletion of the Chd6 exon 12 affects motor coordination.

  Mammalian genome : official journal of the International Mammalian Genome Society 20100401

• Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes.

  Molecular nutrition & food research 20100401

• p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells.

  Oncology reports 20100401

• Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells.

  Cancer prevention research (Philadelphia, Pa.) 20100401

• Phytochemicals in cancer prevention and therapy: truth or dare?

  Toxins 20100401

• Biological profile of erucin: a new promising anticancer agent from cruciferous vegetables.

  Toxins 20100401

• Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury.

  The British journal of nutrition 20100301

• Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention.

  The AAPS journal 20100301

• Sulforaphane protects against cisplatin-induced nephrotoxicity.

  Toxicology letters 20100215

• Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy.

  International journal of pharmaceutics 20100215

• The impact of loss of myrosinase on the bioactivity of broccoli products in F344 rats.

  Journal of agricultural and food chemistry 20100210

• Enhancement of arsenic trioxide cytotoxicity by dietary isothiocyanates in human leukemic cells via a reactive oxygen species-dependent mechanism.

  Leukemia research 20100201

• Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture.

  Experimental dermatology 20100201

• Inhibition of autophagy potentiates sulforaphane-induced apoptosis in human colon cancer cells.

  Annals of surgical oncology 20100201

• Mouse models for unraveling the importance of diet in colon cancer prevention.

  The Journal of nutritional biochemistry 20100201

• Transcriptional regulation of human carboxylesterase 1A1 by nuclear factor-erythroid 2 related factor 2 (Nrf2).

  Biochemical pharmacology 20100115

• Combination treatment with resveratrol and sulforaphane induces apoptosis in human U251 glioma cells.

  Neurochemical research 20100101

• Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner.

  Journal of immunology (Baltimore, Md. : 1950) 20100101

• Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate.

  Arthritis and rheumatism 20100101

• Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice.

  PloS one 20100101

• Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1.

  PloS one 20100101

• Sulforaphane Increases Cyclin-Dependent Kinase Inhibitor, p21 Protein in Human Oral Carcinoma Cells and Nude Mouse Animal Model to Induce G(2)/M Cell Cycle Arrest.

  Journal of clinical biochemistry and nutrition 20100101

• Allyl isothiocyanate that induces GST and UGT expression confers oxidative stress resistance on C. elegans, as demonstrated by nematode biosensor.

  PloS one 20100101

• [Effect of tBHQ and sulforaphane on Nrf2-ARE signaling pathway of Caco2 cells].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20100101

• Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease.

  BMC medical genetics 20100101

• Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.

  Molecular cancer 20100101

• Sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cells.

  Molecular cancer 20100101

• Sulforaphane inhibited melanin synthesis by regulating tyrosinase gene expression in B16 mouse melanoma cells.

  Bioscience, biotechnology, and biochemistry 20100101

• Downregulation of Epidermal Growth Factor Receptor Expression Contributes to alpha-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines.

  Journal of oncology 20100101

• NADPH oxidase limits innate immune responses in the lungs in mice.

  PloS one 20100101

• Individual variation and intraclass correlation in arachidonic acid and eicosapentaenoic acid in chicken muscle.

  Lipids in health and disease 20100101

• Suppression of inflammatory mediators by cruciferous vegetable-derived indole-3-carbinol and phenylethyl isothiocyanate in lipopolysaccharide-activated macrophages.

  Mediators of inflammation 20100101

• Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study.

  BMC cancer 20100101

• Transcript and protein profiling identify candidate gene sets of potential adaptive significance in New Zealand Pachycladon.

  BMC evolutionary biology 20100101

• Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study.

  Therapeutics and clinical risk management 20100101

• Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells.

  BMC cancer 20100101

• Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines.

  PloS one 20100101

• The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer.

  Molecular cancer 20100101

• Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells.

  BMC cancer 20100101

• Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer.

  Journal of molecular signaling 20100101

• The characterisation of AOP2: a gene associated with the biosynthesis of aliphatic alkenyl glucosinolates in Arabidopsis thaliana.

  BMC plant biology 20100101

• The role of tumor initiating cells in drug resistance of breast cancer: Implications for future therapeutic approaches.

  Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20100101

• Sulforaphane induces glutathione S-transferase isozymes which detoxify aflatoxin B(1)-8,9-epoxide in AML 12 cells.

  BioFactors (Oxford, England) 20100101

• Protective effect of combination of sulforaphane and riluzole on glutamate-mediated excitotoxicity.

  Biological & pharmaceutical bulletin 20100101

• Activation of CD147 with cyclophilin a induces the expression of IFITM1 through ERK and PI3K in THP-1 cells.

  Mediators of inflammation 20100101

• Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells.

  Molecular cancer 20100101

• Sulforaphane attenuates matrix metalloproteinase-9 expression following spinal cord injury in mice.

  Annals of clinical and laboratory science 20100101

• Dietary, metabolic, and potentially environmental modulation of the lysine acetylation machinery.

  International journal of cell biology 20100101

• Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways.

  Chinese medicine 20100101

• Novel screening method for potential skin-whitening compounds by a luciferase reporter assay.

  Bioscience, biotechnology, and biochemistry 20100101

• Purification of reversibly oxidized proteins (PROP) reveals a redox switch controlling p38 MAP kinase activity.

  PloS one 20100101

• Cytokines in the Progression of Pancreatic β-Cell Dysfunction.

  International journal of endocrinology 20100101

• Reactivating aberrantly hypermethylated p15 gene in leukemic T cells by a phenylhexyl isothiocyanate mediated inter-active mechanism on DNA and chromatin.

  Journal of hematology & oncology 20100101

• Broccoli, PTEN deletion and prostate cancer: where is the link?

  Molecular cancer 20100101

• Pharmacological targeting of β-adrenergic receptor functions abrogates NF-κB signaling and MMP-9 secretion in medulloblastoma cells.

  OncoTargets and therapy 20100101

• 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.

  BMC cancer 20100101

• Expression and distribution of the class III ubiquitin-conjugating enzymes in the retina.

  Molecular vision 20100101

• Down-regulation of phosphoglucomutase 3 mediates sulforaphane-induced cell death in LNCaP prostate cancer cells.

  Proteome science 20100101

• Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells.

  PloS one 20100101

• Effects of tert-butylhydroquinone on intestinal inflammatory response and apoptosis following traumatic brain injury in mice.

  Mediators of inflammation 20100101

• Neuroprotective role of haptoglobin after intracerebral hemorrhage.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20091216

• Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity.

  American journal of respiratory and critical care medicine 20091215

• Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species.

  The Biochemical journal 20091210

• Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.

  Journal of medicinal chemistry 20091210

• Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line.

  Journal of neurochemistry 20091201

• Sulforaphane inhibits angiogenesis through activation of FOXO transcription factors.

  Oncology reports 20091201

• Effect of sulforaphane on glutathione-adduct formation and on glutathione_S_transferase-dependent detoxification of acrylamide in Caco-2 cells.

  Molecular nutrition & food research 20091201

• Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease.

  Parkinsonism & related disorders 20091201

• Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma.

  Oral oncology 20091101

• Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state.

  Arteriosclerosis, thrombosis, and vascular biology 20091101

• Antioxidant anti-inflammatory treatment in type 2 diabetes.

  Diabetes care 20091101

• Repeated intake of broccoli does not lead to higher plasma levels of sulforaphane in human volunteers.

  Cancer letters 20091018

• Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery.

  Biochemical and biophysical research communications 20091016

• Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells.

  Journal of animal physiology and animal nutrition 20091001

• Modulation of thioredoxin reductase-2 expression in EAhy926 cells: implications for endothelial selenoprotein hierarchy.

  Biochimica et biophysica acta 20091001

• Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway.

  Pharmaceutical research 20091001

• Sulforaphane treatment protects skeletal muscle against damage induced by exhaustive exercise in rats.

  Journal of applied physiology (Bethesda, Md. : 1985) 20091001

• Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6.

  Proceedings of the National Academy of Sciences of the United States of America 20090929

• Gene expression profile of primary prostate epithelial and stromal cells in response to sulforaphane or iberin exposure.

  The Prostate 20090915

• Chemopreventive agent sulforaphane enhances radiosensitivity in human tumor cells.

  International journal of cancer 20090901

• Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090901

• Protective effect of sulforaphane on indomethacin-induced cytotoxicity via heme oxygenase-1 expression in human intestinal Int 407 cells.

  Molecular nutrition & food research 20090901

• Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer.

  Cancer research 20090901

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20090901

• Evaluation of protective effects of sulforaphane on DNA damage caused by exposure to low levels of pesticide mixture using comet assay.

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20090901

• Sulforaphane improves cognitive function administered following traumatic brain injury.

  Neuroscience letters 20090828

• Enantiopure sulforaphane analogues with various substituents at the sulfinyl sulfur: asymmetric synthesis and biological activities.

  The Journal of organic chemistry 20090821

• Sulforaphane enhances caspase-dependent apoptosis through inhibition of cyclooxygenase-2 expression in human oral squamous carcinoma cells and nude mouse xenograft model.

  Oral oncology 20090801

• Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20090801

• The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20090801

• Relevance of the aryl hydrocarbon receptor (AhR) for clinical toxicology.

  Clinical toxicology (Philadelphia, Pa.) 20090801

• Modifying the alkylglucosinolate profile in Arabidopsis thaliana alters the tritrophic interaction with the herbivore Brevicoryne brassicae and parasitoid Diaeretiella rapae.

  Journal of chemical ecology 20090801

• Select phytochemicals suppress human T-lymphocytes and mouse splenocytes suggesting their use in autoimmunity and transplantation.

  Nutrition research (New York, N.Y.) 20090801

• Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling.

  Gut 20090701

• Cellular responses to cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species.

  Pharmaceutical research 20090701

• Sulforaphane: from chemoprevention to pancreatic cancer treatment?

  Gut 20090701

• The aliphatic isothiocyanates erucin and sulforaphane do not effectively up-regulate NAD(P)H:quinone oxidoreductase (NQO1) in human liver compared with rat.

  Molecular nutrition & food research 20090701

• D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells.

  Molecular cancer therapeutics 20090701

• Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential.

  Journal of agricultural and food chemistry 20090624

• Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes.

  The Journal of biological chemistry 20090619

• Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents.

  Toxicology and applied pharmacology 20090615

• Potency of isothiocyanates to induce luciferase reporter gene expression via the electrophile-responsive element from murine glutathione S-transferase Ya.

  Toxicology in vitro : an international journal published in association with BIBRA 20090601

• Initial in vitro evaluations of the antibacterial activities of glucosinolate enzymatic hydrolysis products against plant pathogenic bacteria.

  Journal of applied microbiology 20090601

• The antimicrobial effects of glucosinolates and their respective enzymatic hydrolysis products on bacteria isolated from the human intestinal tract.

  Journal of applied microbiology 20090601

• Potential health benefits of broccoli- a chemico-biological overview.

  Mini reviews in medicinal chemistry 20090601

• E. Solowiej, J. Solowiej, M. Godlewski, et al. Regarding the article 'Application of Sulforaphane: histopathological study of intraportal transplanted pancreatic islets into livers of diabetic rats,' Transplant Proc (2006 Jan/Feb) 38(1): pages 282-283.

  Transplantation proceedings 20090601

• Nrf2 activators provide neuroprotection against 6-hydroxydopamine toxicity in rat organotypic nigrostriatal cocultures.

  Journal of neuroscience research 20090515

• Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090512

• Fragrant unsaturated aldehydes elicit activation of the Keap1/Nrf2 system leading to the upregulation of thioredoxin expression and protection against oxidative stress.

  Antioxidants & redox signaling 20090501

• Down-regulation of the detoxifying enzyme NAD(P)H:quinone oxidoreductase 1 by vanadium in Hepa 1c1c7 cells.

  Toxicology and applied pharmacology 20090501

• Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation.

  Glia 20090415

• An in vitro screening cascade to identify neuroprotective antioxidants in ALS.

  Free radical biology & medicine 20090415

• Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds.

  Environmental and molecular mutagenesis 20090401

• Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kappaB-DNA-binding activity in human bladder T24 cells.

  International journal of oncology 20090401

• Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.

  Cancer prevention research (Philadelphia, Pa.) 20090401

• Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells.

  Cancer letters 20090308

• Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane.

  The Journal of nutritional biochemistry 20090301

• Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma.

  Phytotherapy research : PTR 20090301

• Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway.

  Clinical immunology (Orlando, Fla.) 20090301

• Sensory neurons and schwann cells respond to oxidative stress by increasing antioxidant defense mechanisms.

  Antioxidants & redox signaling 20090301

• Chemical genomics of cancer chemopreventive dithiolethiones.

  Carcinogenesis 20090301

• Effect of broccoli (Brassica oleracea) and its phytochemical sulforaphane in balanced diets on the detoxification enzymes levels of tilapia (Oreochromis niloticus) exposed to a carcinogenic and mutagenic pollutant.

  Chemosphere 20090301

• Comparison of the effects of phenethyl isothiocyanate and sulforaphane on gene expression in breast cancer and normal mammary epithelial cells.

  Experimental biology and medicine (Maywood, N.J.) 20090301

• Functionalized 3-benzylidene-indolin-2-ones: inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity.

  Bioorganic & medicinal chemistry 20090301

• Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells.

  Cancer research 20090301

• [Sulforaphane (1-isothiocyanato-4-(methylsulfinyl)-butane) content in cruciferous vegetables].

  Archivos latinoamericanos de nutricion 20090301

• Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway.

  Toxicology and applied pharmacology 20090215

• Sulforaphane suppresses TNF-alpha-mediated activation of NF-kappaB and induces apoptosis through activation of reactive oxygen species-dependent caspase-3.

  Cancer letters 20090208

• Simple ortho- and para-hydroquinones as compounds neuroprotective against oxidative stress in a manner associated with specific transcriptional activation.

  Biochemical and biophysical research communications 20090206

• Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells.

  The Prostate 20090201

• HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway.

  Toxicological sciences : an official journal of the Society of Toxicology 20090201

• Sulforaphane stimulates activation of proapoptotic protein bax leading to apoptosis of endothelial progenitor cells.

  Annals of surgical oncology 20090201

• Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors.

  Photodermatology, photoimmunology & photomedicine 20090201

• Fenugreek: a naturally occurring edible spice as an anticancer agent.

  Cancer biology & therapy 20090201

• Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane.

  Chemico-biological interactions 20090127

• Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease.

  American journal of respiratory and critical care medicine 20090115

• Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation.

  Pharmaceutical research 20090101

• Receptor independent and receptor dependent CoMSA modeling with IVE-PLS: application to CBG benchmark steroids and reductase activators.

  Journal of molecular modeling 20090101

• Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane.

  Neurochemistry international 20090101

• Involvement of KLF4 in sulforaphane- and iberin-mediated induction of p21(waf1/cip1).

  Nutrition and cancer 20090101

• Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

  BMC medical genomics 20090101

• Protection against amyloid beta cytotoxicity by sulforaphane: role of the proteasome.

  Archives of pharmacal research 20090101

• Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene.

  Journal of biochemical and molecular toxicology 20090101

• The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

  Nuclear receptor signaling 20090101

• Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level.

  PloS one 20090101

• Potential skin antiinflammatory effects of 4-methylthiobutylisothiocyanate (MTBI) isolated from rocket (Eruca sativa) seeds.

  BioFactors (Oxford, England) 20090101

• Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.

  PloS one 20090101

• New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer.

  Journal of hematology & oncology 20090101

• Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response.

  PloS one 20090101

• Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC-1 cancer cells.

  Cancer cell international 20090101

• Modulation of markers associated with aggressive phenotype in MDA-MB-231 breast carcinoma cells by sulforaphane.

  Neoplasma 20090101

• LAS0811: from combinatorial chemistry to activation of antioxidant response element.

  Journal of biomedicine & biotechnology 20090101

• DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase.

  PloS one 20090101

• Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells.

  BMC cancer 20090101

• Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes.

  PloS one 20090101

• Sulforaphane induces DNA double strand breaks predominantly repaired by homologous recombination pathway in human cancer cells.

  Biochemical and biophysical research communications 20081212

• Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis.

  British journal of cancer 20081209

• Isothiocyanate NB7M causes selective cytotoxicity, pro-apoptotic signalling and cell-cycle regression in ovarian cancer cells.

  British journal of cancer 20081202

• A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction.

  Journal of neurochemistry 20081201

• Suppression of microtubule dynamic instability and turnover in MCF7 breast cancer cells by sulforaphane.

  Carcinogenesis 20081201

• Bioavailability and kinetics of sulforaphane in humans after consumption of cooked versus raw broccoli.

  Journal of agricultural and food chemistry 20081126

• Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20081101

• Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.

  Journal of natural products 20081101

• Monodictyochromes A and B, dimeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis.

  Journal of natural products 20081101

• Epithiospecifier protein activity in broccoli: the link between terminal alkenyl glucosinolates and sulphoraphane nitrile.

  Phytochemistry 20081101

• Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20081101

• Up-regulation of the CYP1 family in rat and human liver by the aliphatic isothiocyanates erucin and sulforaphane.

  Toxicology 20081030

• Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway.

  Biochemical pharmacology 20081015

• Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles.

  Proceedings of the National Academy of Sciences of the United States of America 20081014

• Multi-targeted prevention of cancer by sulforaphane.

  Cancer letters 20081008

• The dietary histone deacetylase inhibitor sulforaphane induces human beta-defensin-2 in intestinal epithelial cells.

  Immunology 20081001

• Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease.

  Diabetes 20081001

• Role of reactive oxygen intermediates in cellular responses to dietary cancer chemopreventive agents.

  Planta medica 20081001

• Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry.

  Chemical research in toxicology 20081001

• Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione.

  Journal of neurochemistry 20081001

• Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1.

  American journal of respiratory and critical care medicine 20080915

• Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cells.

  International journal of cancer 20080915

• Modulation of rat hepatic and pulmonary cytochromes P450 and phase II enzyme systems by erucin, an isothiocyanate structurally related to sulforaphane.

  Journal of agricultural and food chemistry 20080910

• Application of high-speed countercurrent chromatography for the isolation of sulforaphane from broccoli seed meal.

  Journal of agricultural and food chemistry 20080910

• Computational discovery of novel low micromolar human pregnane X receptor antagonists.

  Molecular pharmacology 20080901

• Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death.

  Molecular and cellular neurosciences 20080901

• Cancer is a preventable disease that requires major lifestyle changes.

  Pharmaceutical research 20080901

• Effect of (R)L-sulforaphane on 5-aminolevulinic acid-mediated photodynamic therapy.

  Translational research : the journal of laboratory and clinical medicine 20080901

• Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications.

  Current drug metabolism 20080901

• Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response.

  Environmental health perspectives 20080901

• Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats.

  Evidence-based complementary and alternative medicine : eCAM 20080901

• Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis.

  The Journal of biological chemistry 20080808

• Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction.

  Toxicology and applied pharmacology 20080801

• Genetic polymorphisms in the 5'-flanking region of human UDP-glucuronosyltransferase 2B7 affect the Nrf2-dependent transcriptional regulation.

  Pharmacogenetics and genomics 20080801

• Stress-associated hormone, norepinephrine, increases proliferation and IL-6 levels of human pancreatic duct epithelial cells and can be inhibited by the dietary agent, sulforaphane.

  International journal of oncology 20080801

• Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates.

  Nutrition reviews 20080801

• Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo(a)pyrene and their mode of action.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701

• The transcription factor Nrf2 is a therapeutic target against brain inflammation.

  Journal of immunology (Baltimore, Md. : 1950) 20080701

• Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells.

  Cancer research 20080701

• Direct and indirect antioxidant properties of inducers of cytoprotective proteins.

  Molecular nutrition & food research 20080601

• Translating knowledge generated by epidemiological and in vitro studies into dietary cancer prevention.

  Molecular nutrition & food research 20080601

• Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme.

  Biochemical pharmacology 20080601

• The diet-derived sulforaphane inhibits matrix metalloproteinase-9-activated human brain microvascular endothelial cell migration and tubulogenesis.

  Molecular nutrition & food research 20080601

• Putative mechanisms of action for indole-3-carbinol in the prevention of colorectal cancer.

  Expert opinion on therapeutic targets 20080601

• Growth inhibition of a spectrum of bacterial and fungal pathogens by sulforaphane, an isothiocyanate product found in broccoli and other cruciferous vegetables.

  Planta medica 20080601

• Demonstration by redox fluorometry that sulforaphane protects retinal pigment epithelial cells against oxidative stress.

  Investigative ophthalmology & visual science 20080601

• Resveratrol in prevention and treatment of common clinical conditions of aging.

  Clinical interventions in aging 20080601

• Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells.

  The Journal of allergy and clinical immunology 20080501

• Protective effects of an extract of young radish (Raphanus sativus L) cultivated with sulfur (sulfur-radish extract) and of sulforaphane on carbon tetrachloride-induced hepatotoxicity.

  Bioscience, biotechnology, and biochemistry 20080501

• Sulforaphane and erucin increase MRP1 and MRP2 in human carcinoma cell lines.

  The Journal of nutritional biochemistry 20080401

• Liquid microjunction surface sampling probe electrospray mass spectrometry for detection of drugs and metabolites in thin tissue sections.

  Journal of mass spectrometry : JMS 20080401

• Synergistic neurotoxic effects of arsenic and dopamine in human dopaminergic neuroblastoma SH-SY5Y cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20080401

• Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphane.

  Carcinogenesis 20080401

• Modulation of Nrf2-dependent antioxidant functions in the RPE by Zip2, a zinc transporter protein.

  Investigative ophthalmology & visual science 20080401

• Essential roles of the PI3 kinase/Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE.

  Investigative ophthalmology & visual science 20080401

• Identification, synthesis, and enzymology of non-natural glucosinolate chemopreventive candidates.

  Chembiochem : a European journal of chemical biology 20080325

• Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat.

  The British journal of nutrition 20080301

• Cytotoxic and antioxidant activity of 4-methylthio-3-butenyl isothiocyanate from Raphanus sativus L. (Kaiware Daikon) sprouts.

  Journal of agricultural and food chemistry 20080213

• Synergistic effects of a combination of dietary factors sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells.

  Pharmaceutical research 20080201

• The significance of Nrf2 pathway in (photo)-oxidative stress response in melanocytes and keratinocytes of the human epidermis.

  Pigment cell & melanoma research 20080201

• Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080109

• Evaluation of the safety and bioactivity of purified and semi-purified glucoraphanin.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080101

• Dietary factors, hormesis and health.

  Ageing research reviews 20080101

• Sulforaphane inhibition of monocyte adhesion via the suppression of ICAM-1 and NF-kappaB is dependent upon glutathione depletion in endothelial cells.

  Vascular pharmacology 20080101

• Prevention of Oxidative Stress-Induced Retinal Pigment Epithelial Cell Death by the PPARgamma Agonists, 15-Deoxy-Delta 12, 14-Prostaglandin J(2).

  PPAR research 20080101

• The first generation of a BAC-based physical map of Brassica rapa.

  BMC genomics 20080101

• Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate.

  PloS one 20080101

• Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress.

  Cardiovascular toxicology 20080101

• Induction of differentiation in human promyelocytic cells by the isothiocyanate sulforaphane.

  In vivo (Athens, Greece) 20080101

• Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells.

  Nutrition and cancer 20080101

• Antimicrobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia.

  Chinese medicine 20080101

• Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway.

  Mediators of inflammation 20080101

• Strategies for prostate cancer prevention: Review of the literature.

  Indian journal of urology : IJU : journal of the Urological Society of India 20080101

• Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells.

  Drug design, development and therapy 20080101

• Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration.

  Journal of inflammation research 20080101

• Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes.

  European journal of pharmacology 20071222

• Broccoli extract may help reduce UV skin damage.

  JAMA 20071219

• Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 (COX-2) expression through the modulation of multiple targets in COX-2 gene promoter.

  International immunopharmacology 20071215

• Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: a mechanism of cancer chemoprotection.

  Cancer letters 20071208

• Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity.

  Toxicology and applied pharmacology 20071201

• Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage.

  Stroke 20071201

• Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells.

  European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20071201

• Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo.

  Oncology reports 20071101

• Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse.

  Cancer research 20071015

• Separation and purification of sulforaphane from broccoli seeds by solid phase extraction and preparative high-performance liquid chromatography.

  Journal of agricultural and food chemistry 20071003

• Dietary histone deacetylase inhibitors: from cells to mice to man.

  Seminars in cancer biology 20071001

• Sulforaphane induces growth arrest and apoptosis in human ovarian cancer cells.

  Acta obstetricia et gynecologica Scandinavica 20071001

• Role of NF-kappaB and MAPKs in light-induced photoreceptor apoptosis.

  Investigative ophthalmology & visual science 20071001

• Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents.

  Biological chemistry 20071001

• Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070919

• Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells.

  Free radical biology & medicine 20070901

• Keap1 eye on the target: chemoprevention of liver cancer.

  Acta pharmacologica Sinica 20070901

• Discovery and development of sulforaphane as a cancer chemopreventive phytochemical.

  Acta pharmacologica Sinica 20070901

• Immunomodulatory activity of Sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea).

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20070801

• Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line.

  Molecular nutrition & food research 20070801

• Quantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitro.

  Carcinogenesis 20070701

• Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast.

  Carcinogenesis 20070701

• Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3.

  Oncology reports 20070701

• The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells.

  Cancer research 20070701

• Quinone reductase induction activity of methoxylated analogues of resveratrol.

  European journal of medicinal chemistry 20070601

• Identification of a flavin-monooxygenase as the S-oxygenating enzyme in aliphatic glucosinolate biosynthesis in Arabidopsis.

  The Plant journal : for cell and molecular biology 20070601

• Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells.

  Carcinogenesis 20070501

• Delay of photoreceptor degeneration in tubby mouse by sulforaphane.

  Journal of neurochemistry 20070501

• Molecular basis for chemoprevention by sulforaphane: a comprehensive review.

  Cellular and molecular life sciences : CMLS 20070501

• Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell line.

  Molecular cancer therapeutics 20070501

• The metabolic fate of purified glucoraphanin in F344 rats.

  Journal of agricultural and food chemistry 20070418

• Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.

  Toxicological sciences : an official journal of the Society of Toxicology 20070401

• Protective effect of sulforaphane against dopaminergic cell death.

  The Journal of pharmacology and experimental therapeutics 20070401

• Effect of meal composition and cooking duration on the fate of sulforaphane following consumption of broccoli by healthy human subjects.

  The British journal of nutrition 20070401

• Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070401

• Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.

  Pharmacological research 20070301

• Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines.

  Molecular cancer therapeutics 20070301

• The influence of processing and preservation on the retention of health-promoting compounds in broccoli.

  Journal of food science 20070301

• Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells.

  Journal of agricultural and food chemistry 20070221

• Sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization.

  Vascular pharmacology 20070201

• Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.

  Carcinogenesis 20070201

• Selenium and sulforaphane modify the expression of selenoenzymes in the human endothelial cell line EAhy926 and protect cells from oxidative damage.

  Nutrition (Burbank, Los Angeles County, Calif.) 20070201

• Variation of glucosinolates in vegetable crops of Brassica rapa.

  Phytochemistry 20070201

• Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects.

  Experimental biology and medicine (Maywood, N.J.) 20070201

• Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract.

  American journal of physiology. Lung cellular and molecular physiology 20070101

• D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1.

  Carcinogenesis 20070101

• The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor.

  Molecular pharmacology 20070101

• Sulforaphane as a promising molecule for fighting cancer.

  Mutation research 20070101

• Antiproliferative activity of sulforaphane in Akt-overexpressing ovarian cancer cells.

  Molecular cancer therapeutics 20070101

• Differential response of human healthy lymphoblastoid and CCRF-SB leukemia cells to sulforaphane and its two analogues: 2-oxohexyl isothiocyanate and alyssin.

  Pharmacological reports : PR 20070101

• Combination of doxorubicin and sulforaphane for reversing doxorubicin-resistant phenotype in mouse fibroblasts with p53Ser220 mutation.

  Annals of the New York Academy of Sciences 20070101

• Diet, genetic polymorphisms, detoxification, and health risks.

  Alternative therapies in health and medicine 20070101

• Chemoprotection against cancer: an idea whose time has come.

  Alternative therapies in health and medicine 20070101

• Cell-cycle specificity of sulforaphane-mediated apoptosis in Jurkat T-leukemia cells.

  In vivo (Athens, Greece) 20070101

• MAK-4 and -5 supplemented diet inhibits liver carcinogenesis in mice.

  BMC complementary and alternative medicine 20070101

• Minocycline and sulforaphane inhibited lipopolysaccharide-mediated retinal microglial activation.

  Molecular vision 20070101

• Modulation of cell-mediated immune response in B16F-10 melanoma-induced metastatic tumor-bearing C57BL/6 mice by sulforaphane.

  Immunopharmacology and immunotoxicology 20070101

• Antioxidant enzyme induction: a new protective approach against the adverse effects of diesel exhaust particles.

  Inhalation toxicology 20070101

• The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase.

  BMC cancer 20070101

• Human agonistic TRAIL receptor antibodies Mapatumumab and Lexatumumab induce apoptosis in malignant mesothelioma and act synergistically with cisplatin.

  Molecular cancer 20070101

• In vitro antiproliferative effects of sulforaphane on human colon cancer cell line SW620.

  Acta medica (Hradec Kralove) 20070101

• Genomic loci modulating the retinal transcriptome in wound healing.

  Gene regulation and systems biology 20070101

• Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts.

  Journal of agricultural and food chemistry 20061213

• PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex.

  The Journal of biological chemistry 20061208

• Quantitative measurement of sulforaphane, iberin and their mercapturic acid pathway metabolites in human plasma and urine using liquid chromatography-tandem electrospray ionisation mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061205

• Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice.

  Biopharmaceutics & drug disposition 20061201

• Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.

  Cancer letters 20061118

• Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts characterized by p53 mutations.

  Mutation research 20061010

• Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable.

  Carcinogenesis 20061001

• Effect of sulforaphane on cell growth, G(0)/G(1) phase cell progression and apoptosis in human bladder cancer T24 cells.

  International journal of oncology 20061001

• Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters.

  Cancer letters 20060928

• Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain.

  The Journal of biological chemistry 20060915

• Fatal enterocolitis in Asian elephants (Elephas maximus) caused by Clostridium difficile.

  Veterinary microbiology 20060910

• Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells.

  Carcinogenesis 20060901

• Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane.

  Neuroscience 20060901

• Phase II enzymes induction blocks the enhanced IgE production in B cells by diesel exhaust particles.

  Journal of immunology (Baltimore, Md. : 1950) 20060901

• Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells.

  Cancer research 20060901

• Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts.

  Cancer letters 20060828

• Simultaneous determination of sulforaphane and its major metabolites from biological matrices with liquid chromatography-tandem mass spectroscopy.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060818

• Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

  Cancer research 20060815

• Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation.

  The Journal of allergy and clinical immunology 20060801

• Part of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer.

  Free radical research 20060801

• Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae.

  Mutation research 20060725

• Haplotype-environment interactions that regulate the human glutathione S-transferase P1 promoter.

  Cancer research 20060615

• Dietary agents as histone deacetylase inhibitors.

  Molecular carcinogenesis 20060601

• Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells.

  Cancer research 20060601

• Antimetastatic activity of Sulforaphane.

  Life sciences 20060522

• Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion.

  Cancer letters 20060508

• Aqueous extracts of selenium-fertilized broccoli increase selenoprotein activity and inhibit DNA single-strand breaks, but decrease the activity of quinone reductase in Hepa 1c1c7 cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060501

• Evaporative light-scattering analysis of sulforaphane in broccoli samples: Quality of broccoli products regarding sulforaphane contents.

  Journal of agricultural and food chemistry 20060405

• Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells.

  Carcinogenesis 20060401

• Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane.

  Current drug targets 20060401

• Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract.

  Molecular cancer therapeutics 20060401

• Isothiocyanates stimulating oviposition by the diamondback moth, Plutella xylostella.

  Journal of chemical ecology 20060401

• Epithiospecifier protein from broccoli (Brassica oleracea L. ssp. italica) inhibits formation of the anticancer agent sulforaphane.

  Journal of agricultural and food chemistry 20060322

• Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, induces phase-I xenobiotic metabolizing enzymes and increases free radical generation in rat liver.

  Mutation research 20060320

• Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.

  FEBS letters 20060320

• Effect of isothiocyanates on nuclear accumulation of NF-kappaB, Nrf2, and thioredoxin in caco-2 cells.

  Journal of agricultural and food chemistry 20060308

• ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.

  Carcinogenesis 20060301

• The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells.

  The Journal of pharmacology and experimental therapeutics 20060301

• Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301

• The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells.

  Anti-cancer drugs 20060301

• Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis.

  Current cancer drug targets 20060301

• Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention.

  Molecular cancer therapeutics 20060301

• Bioactive dammarane triterpenes from the mangrove plant Bruguiera gymnorrhiza.

  Journal of natural products 20060301

• Quinone reductase induction as a biomarker for cancer chemoprevention.

  Journal of natural products 20060301

• Suppressive effects of young radish cultivated with sulfur on growth and metastasis of B16-F10 melanoma cells.

  Archives of pharmacal research 20060301

• Chemoprotection by sulforaphane: keep one eye beyond Keap1.

  Cancer letters 20060227

• p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1.

  Cancer chemotherapy and pharmacology 20060201

• Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?

  Carcinogenesis 20060201

• Dietary approaches to positively influence fetal determinants of adult health.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060201

• Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5.

  Cancer research 20060201

• Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents.

  Neuroscience letters 20060130

• Cancer chemopreventive activity of sulforamate derivatives.

  European journal of medicinal chemistry 20060101

• Application of sulforaphane: histopathological study of intraportal transplanted pancreatic islets into livers of diabetic rats.

  Transplantation proceedings 20060101

• Modest induction of phase 2 enzyme activity in the F-344 rat prostate.

  BMC cancer 20060101

• Indirect antioxidant protection against photooxidative processes initiated in retinal pigment epithelial cells by a lipofuscin pigment.

  Rejuvenation research 20060101

• Sulforaphane induces inhibition of human umbilical vein endothelial cells proliferation by apoptosis.

  Angiogenesis 20060101

• Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.

  Nutrition and cancer 20060101

• Pretreatment of human epidermal keratinocytes with D,L-sulforaphane protects against sulfur mustard cytotoxicity.

  Cutaneous and ocular toxicology 20060101

• Augmentation of natural killer cell and antibody-dependent cellular cytotoxicity in BALB/c mice by sulforaphane, a naturally occurring isothiocyanate from broccoli through enhanced production of cytokines IL-2 and IFN-gamma.

  Immunopharmacology and immunotoxicology 20060101

• Ethanol sensitivity: a central role for CREB transcription regulation in the cerebellum.

  BMC genomics 20060101

• Sulforaphane inhibits osteoclastogenesis by inhibiting nuclear factor-kappaB.

  Molecules and cells 20051231

• Purification of sulforaphane from Brassica oleracea seed meal using low-pressure column chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051215

• Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells.

  Toxicology and applied pharmacology 20051201

• Effect of sulforaphane on micronucleus induction in cultured human lymphocytes by four different mutagens.

  Environmental and molecular mutagenesis 20051201

• Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells.

  Carcinogenesis 20051201

• Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane.

  Chemical research in toxicology 20051201

• An anthraquinone with potent quinone reductase-inducing activity and other constituents of the fruits of Morinda citrifolia (noni).

  Journal of natural products 20051201

• Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury.

  Journal of neuroscience research 20051115

• Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity.

  International journal of cancer 20051110

• Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20051101

• [Effects of sulforaphane-rich broccoli sprouts on H. pylori-infected gastric mucosa].

  Nihon rinsho. Japanese journal of clinical medicine 20051101

• Chinese cabbage extracts and sulforaphane can protect H2O2-induced inhibition of gap junctional intercellular communication through the inactivation of ERK1/2 and p38 MAP kinases.

  Journal of agricultural and food chemistry 20051019

• Overexpression of regucalcin suppresses cell proliferation of cloned normal rat kidney proximal tubular epithelial NRK52E cells.

  International journal of molecular medicine 20051001

• Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20051001

• Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.

  Cancer research 20050915

• Effect of NQO1 induction on the antitumor activity of RH1 in human tumors in vitro and in vivo.

  Cancer chemotherapy and pharmacology 20050901

• Detoxication enzyme inducers modify cytokine production in rat mixed glial cells.

  Journal of neuroimmunology 20050901

• Overexpression of regucalcin suppresses cell proliferation in cloned rat hepatoma H4-II-E cells: involvement of intracellular signaling factors and cell cycle-related genes.

  Journal of cellular biochemistry 20050815

• Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif.

  The Journal of biological chemistry 20050805

• Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells.

  Molecular cancer therapeutics 20050801

• Phytochemicals in broccoli transcriptionally induce thioredoxin reductase.

  Journal of agricultural and food chemistry 20050713

• Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.

  Oncogene 20050630

• Nrf2 as a novel molecular target for chemoprevention.

  Cancer letters 20050628

• A mutated p53 status did not prevent the induction of apoptosis by sulforaphane, a promising anti-cancer drug.

  Investigational new drugs 20050601

• Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells.

  Biochemical pharmacology 20050601

• Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.

  The Journal of biological chemistry 20050520

• Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.

  Biochemistry 20050510

• Overexpression of regucalcin suppresses apoptotic cell death in the cloned rat hepatoma H4-II-E cells induced by a naturally occurring isothiocyanate sulforaphane.

  International journal of molecular medicine 20050501

• Direct antioxidant activity of purified glucoerucin, the dietary secondary metabolite contained in rocket (Eruca sativa Mill.) seeds and sprouts.

  Journal of agricultural and food chemistry 20050406

• Micronucleus formation and induction of apoptosis by different isothiocyanates and a mixture of isothiocyanates in human lymphocyte cultures.

  Mutation research 20050404

• Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations.

  Oncology reports 20050401

• Evaluation of the antimicrobial effects of several isothiocyanates on Helicobacter pylori.

  Planta medica 20050401

• Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.

  Journal of biochemistry and molecular biology 20050331

• [Induction of uridine 5'-diphosphate-glucuronosyltransferase gene expression by sulforaphane and its mechanism: experimental study in human colon cancel cells].

  Zhonghua yi xue za zhi 20050330

• Sulforaphane, erucin, and iberin up-regulate thioredoxin reductase 1 expression in human MCF-7 cells.

  Journal of agricultural and food chemistry 20050309

• Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice.

  Investigative ophthalmology & visual science 20050301

• Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent.

  Cancer research 20050301

• Induction of phase I, II and III drug metabolism/transport by xenobiotics.

  Archives of pharmacal research 20050301

• Effects of dietary chemopreventive phytochemicals on P-glycoprotein function.

  Biochemical and biophysical research communications 20050218

• Red maca (Lepidium meyenii) reduced prostate size in rats.

  Reproductive biology and endocrinology : RB&E 20050101

• Animal models and analytical approaches for understanding the relationships between wine and cancer.

  Drugs under experimental and clinical research 20050101

• Isothiocyanates induce cell cycle arrest, apoptosis and mitochondrial potential depolarization in HL-60 and multidrug-resistant cell lines.

  Anticancer research 20050101

• Induction of quinone reductase by sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells.

  Journal of medicinal food 20050101

• Cultivation conditions and selenium fertilization alter the phenolic profile, glucosinolate, and sulforaphane content of broccoli.

  Journal of medicinal food 20050101

• Involvement of c-Jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU145 prostate cancer cells.

  Nutrition and cancer 20050101

• Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress.

  Inflammopharmacology 20050101

• Time-dependent modulation of thioredoxin reductase activity might contribute to sulforaphane-mediated inhibition of NF-kappaB binding to DNA.

  Antioxidants & redox signaling 20050101

• Oltipraz, 3H-1,2-dithiole-3-thione, and sulforaphane induce overlapping and protective antioxidant responses in murine microglial cells.

  Toxicology letters 20041128

• Ebselen augments its peroxidase activity by inducing nrf-2-dependent transcription.

  Archives of biochemistry and biophysics 20041115

• Phase II enzyme inducer, sulforaphane, inhibits UVB-induced AP-1 activation in human keratinocytes by a novel mechanism.

  Molecular carcinogenesis 20041101

• Sulforaphane halts breast cancer cell growth.

  Drug discovery today 20041101

• Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo.

  British journal of cancer 20041018

• The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.

  Molecular cancer therapeutics 20041001

• Isothiocyanates as novel cytotoxic and cytostatic agents: molecular pathway on human transformed and non-transformed cells.

  Biochemical pharmacology 20040915

• Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells.

  Carcinogenesis 20040901

• Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines.

  Experimental biology and medicine (Maywood, N.J.) 20040901

• A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.

  Cancer research 20040815

• Oral broccoli sprouts for the treatment of Helicobacter pylori infection: a preliminary report.

  Digestive diseases and sciences 20040801

• In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat.

  The Journal of pharmacology and experimental therapeutics 20040701

• Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes.

  Xenobiotica; the fate of foreign compounds in biological systems 20040701

• Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.

  The Journal of biological chemistry 20040611

• Broccoli consumption and chronic atrophic gastritis among Japanese males: an epidemiological investigation.

  Acta medica Okayama 20040601

• Heating decreases epithiospecifier protein activity and increases sulforaphane formation in broccoli.

  Phytochemistry 20040501

• Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds.

  Journal of agricultural and food chemistry 20040407

• Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line.

  Pharmaceutical research 20040401

• Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway.

  Pharmaceutical research 20040401

• Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium.

  Integrative cancer therapies 20040301

• Glucoraphanin and 4-hydroxyglucobrassicin contents in seeds of 59 cultivars of broccoli, raab, kohlrabi, radish, cauliflower, brussels sprouts, kale, and cabbage.

  Journal of agricultural and food chemistry 20040225

• Cellular accumulation of dietary anticarcinogenic isothiocyanates is followed by transporter-mediated export as dithiocarbamates.

  Cancer letters 20040210

• Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040204

• Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization.

  Carcinogenesis 20040201

• Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables.

  Cancer letters 20040108

• Induction of cytochrome P450, generation of oxidative stress and in vitro cell-transforming and DNA-damaging activities by glucoraphanin, the bioprecursor of the chemopreventive agent sulforaphane found in broccoli.

  Carcinogenesis 20040101

• Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo.

  Carcinogenesis 20040101

• Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention.

  International journal of oncology 20040101

• Sulforaphane inhibits growth of a colon cancer cell line.

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20040101

• Effects of different processing methods on induction of quinone reductase by dietary broccoli in rats.

  Journal of medicinal food 20040101

• Effects of dietary anticarcinogens and nonsteroidal anti-inflammatory drugs on rat gastrointestinal UDP-glucuronosyltransferases.

  Anticancer research 20040101

• Inhibition by allyl sulfides and phenethyl isothiocyanate of methyl-n-pentylnitrosamine depentylation by rat esophageal microsomes, human and rat CYP2E1, and Rat CYP2A3.

  Nutrition and cancer 20040101

• Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells.

  Nutrition and cancer 20040101

• Sulforaphane-mediated induction of a phase 2 detoxifying enzyme NAD(P)H:quinone reductase and apoptosis in human lymphoblastoid cells.

  Acta biochimica Polonica 20040101

• Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk.

  Nutrition and cancer 20040101

• Application of sulforaphane--does it lead to improvement of islet graft survival after warm and/or cold ischemia.

  Annals of transplantation 20040101

• Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes.

  Carcinogenesis 20031201

• Sulforaphane modulates cell cycle and apoptosis in transformed and non-transformed human T lymphocytes.

  Annals of the New York Academy of Sciences 20031201

• Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element.

  Molecular pharmacology 20031101

• Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane.

  Cancer research 20031101

• Selected isothiocyanates rapidly induce growth inhibition of cancer cells.

  Molecular cancer therapeutics 20031001

• Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence.

  The Biochemical journal 20030901

• Thioredoxin reductase in human hepatoma cells is transcriptionally regulated by sulforaphane and other electrophiles via an antioxidant response element.

  The Journal of nutrition 20030901

• Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria.

  Journal of natural products 20030901

• Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase.

  Journal of natural products 20030901

• Voltammetric and electrochemical quartz crystal microbalance studies of sulforaphane and its Zn(II) complexes.

  Journal of pharmaceutical and biomedical analysis 20030808

• Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora.

  Journal of natural products 20030801

• Naturally occurring Phe151Leu substitution near a conserved folding module lowers stability of glutathione transferase P1-1.

  Biochimica et biophysica acta 20030626

• Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression.

  The Journal of biological chemistry 20030613

• Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo.

  Drug metabolism and disposition: the biological fate of chemicals 20030601

• Food matrix effects on bioactivity of broccoli-derived sulforaphane in liver and colon of F344 rats.

  Journal of agricultural and food chemistry 20030521

• Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean).

  Journal of natural products 20030501

• Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers.

  Life sciences 20030404

• The effect of indole-3-carbinol and sulforaphane on a prostate cancer cell line.

  ANZ journal of surgery 20030301

• Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation.

  Carcinogenesis 20030301

• Inhibition of mutagenicity of food-derived heterocyclic amines by sulforaphane--a constituent of broccoli.

  Indian journal of experimental biology 20030301

• Chemoprevention of cancerogenesis--the role of sulforaphane.

  Acta poloniae pharmaceutica 20030101

• [Herb honey containing sulforaphane-aglycone with potential use in cancer prophylaxis].

  Roczniki Panstwowego Zakladu Higieny 20030101

• Sulforaphane and 2-oxohexyl isothiocyanate induce cell growth arrest and apoptosis in L-1210 leukemia and ME-18 melanoma cells.

  Oncology reports 20030101

• Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung.

  Cancer letters 20021210

• Plant-derived biomolecules in fermented cabbage.

  Journal of agricultural and food chemistry 20021106

• Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase.

  Journal of natural products 20021101

• Cyclin D3 and p53 mediate sulforaphane-induced cell cycle delay and apoptosis in non-transformed human T lymphocytes.

  Cellular and molecular life sciences : CMLS 20021101

• Influence of temperature and ontogeny on the levels of glucosinolates in broccoli (Brassica oleracea Var. italica) sprouts and their effect on the induction of mammalian phase 2 enzymes.

  Journal of agricultural and food chemistry 20021009

• Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes.

  Current drug metabolism 20021001

• Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine.

  Pharmaceutical research 20021001

• Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.

  Cancer research 20020915

• Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi.

  Journal of medicinal chemistry 20020829

• Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells.

  Carcinogenesis 20020801

• Glucosinolates of seven medicinal plants from Thailand.

  Fitoterapia 20020601

• Glucosinolate research in the Arabidopsis era.

  Trends in plant science 20020601

• High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate.

  The Biochemical journal 20020515

• Induction of quinone reductase by withanolides.

  Journal of natural products 20020501

• Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane.

  Carcinogenesis 20020401

• Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells.

  International journal of oncology 20020301

• A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway.

  The Journal of biological chemistry 20020201

• Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans.

  Clinica chimica acta; international journal of clinical chemistry 20020201

• The drug efflux pump MRP2: regulation of expression in physiopathological situations and by endogenous and exogenous compounds.

  Cell biology and toxicology 20020101

• The cruciferous nitrile crambene has bioactivity similar to sulforaphane when administered to Fischer 344 rats but is far less potent in cell culture.

  Nutrition and cancer 20020101

• Micronutrients and the regulation of cancerous cell growth and death: effect of sulforaphane, an isothiocyanate from broccoli.

  IARC scientific publications 20020101

• Botanicals in cancer chemoprevention.

  Cancer metastasis reviews 20020101

• Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile.

  Journal of agricultural and food chemistry 20011201

• Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of Phase 2 detoxification enzymes.

  Carcinogenesis 20011201

• The impaired glutathione system and its up-regulation by sulforaphane in vascular smooth muscle cells from spontaneously hypertensive rats.

  Journal of hypertension 20011001

• Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens.

  Mutation research 20010901

• Potent induction of phase 2 enzymes in human prostate cells by sulforaphane.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010901

• Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes.

  Chemical research in toxicology 20010901

• A review of cancer chemopreventive agents.

  Current medicinal chemistry 20010901

• Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms.

  The Journal of biological chemistry 20010824

• The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

  Cancer research 20010415

• Study of the role of antimicrobial glucosinolate-derived isothiocyanates in resistance of Arabidopsis to microbial pathogens.

  Plant physiology 20010401

• Preparative HPLC method for the purification of sulforaphane and sulforaphane nitrile from Brassica oleracea.

  Journal of agricultural and food chemistry 20010401

• Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane.

  Biochemical and biophysical research communications 20010323

• Molecular mechanism of rapid cellular accumulation of anticarcinogenic isothiocyanates.

  Carcinogenesis 20010301

• The importance of using scientific principles in the development of medicinal agents from plants.

  Academic medicine : journal of the Association of American Medical Colleges 20010301

• Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dioxygenases control glucosinolate biosynthesis in Arabidopsis.

  The Plant cell 20010301

• Inhibition of CYP2E1 with natural agents may be a feasible strategy for minimizing the hepatotoxicity of ethanol.

  Medical hypotheses 20010101

• Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).

  Drug metabolism reviews 20010101

• Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane.

  Chemical research in toxicology 20000401

• Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels.

  Carcinogenesis 19981101

• Electrophile and antioxidant regulation of enzymes that detoxify carcinogens.

  Proceedings of the National Academy of Sciences of the United States of America 19950912

• Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases.

  Biochemical and biophysical research communications 19950117

• A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.

  Proceedings of the National Academy of Sciences of the United States of America 19920315