4494-26-2 | 5-Formyl-2'-deoxyuridine

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$303.00	$212.00
1g	95%	in stock	$950.00	$665.00

Description

• Catalog Number: AB69284
• Chemical Name: 5-Formyl-2'-deoxyuridine
• CAS Number: 4494-26-2
• Molecular Formula: C10H12N2O6
• Molecular Weight: 256.2121
• MDL Number: MFCD01689820
• SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1cc(C=O)c(=O)[nH]c1=O

Computed Properties

• Complexity: 421
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 3
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 3
• XLogP3: -1.9

Literature

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  ChemMedChem 20121001

• Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines.

  Bioorganic & medicinal chemistry 20120101

• ATP chemosensitivity testing of new antitumor duplex drugs linking 3`-C-ethynylycytidine (ECyd) and 2´-deoxy-5-fluorouridine (5-FdU) in comparison to standard cytostatica and combinations thereof.

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• Quantification of oxidative DNA lesions in tissues of Long-Evans Cinnamon rats by capillary high-performance liquid chromatography-tandem mass spectrometry coupled with stable isotope-dilution method.

  Analytical chemistry 20110315

• Selective detection of 5-formyl-2'-deoxyuridine, an oxidative lesion of thymidine, in DNA by a fluorogenic reagent.

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• Solvent-free synthesis of pyrimidine nucleoside-aminophosphonate hybrids and their biological activity evaluation.

  Nucleosides, nucleotides & nucleic acids 20100801

• Synthesis and properties of new fluorescent nucleosides and oligodeoxynucleotides derived from 5-formyl-2'-deoxyuridine.

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• Synthesis of 5-formyl-2'-deoxyuridine and its incorporation into oligodeoxynucleotides.

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• Novel enamine derivatives of 5,6-dihydro-2'-deoxyuridine formed in reductive amination of 5-formyl-2'-deoxyuridine.

  Nucleosides, nucleotides & nucleic acids 20080901

• Development of a novel selective detection method for 5-formyl-2'-deoxyuridine by fluorescent derivatization.

  Nucleic acids symposium series (2004) 20080101

• Derivatization with Girard reagent T combined with LC-MS/MS for the sensitive detection of 5-formyl-2'-deoxyuridine in cellular DNA.

  Analytical chemistry 20070101

• Structurally diverse 5-substituted pyrimidine nucleosides as inhibitors of Leishmania donovani promastigotes in vitro.

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• 5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activity.

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• Aggregation of RecA-derived peptides on single-stranded oligonucleotides triggered by schiff base-mediated crosslinking.

  Bioorganic & medicinal chemistry letters 20030901

• Water mediated Dickerson-Drew-type crystal of DNA dodecamer containing 2'-deoxy-5-formyluridine.

  Biophysical chemistry 20020328

• Mutations induced by 5-formyl-2'-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine.

  Mutation research 20010509

• 5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism.

  Toxicology letters 20010203

• Crystallization and preliminary X-ray analysis of a DNA dodecamer containing 2'-deoxy-5-formyluridine; what is the role of magnesium cation in crystallization of Dickerson-type DNA dodecamers?

  Acta crystallographica. Section D, Biological crystallography 20010201

• Chemical cross-linking of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine.

  Nucleosides, nucleotides & nucleic acids 20010101

• Evidence for a Schiff base formation of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine.

  Nucleic acids research. Supplement (2001) 20010101

• X-ray analyses of DNA dodecamers containing 2'-deoxy-5-formyluridine.

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• Antiherpes activity of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil and some other 5-substituted uracil arabinosyl nucleosides in two different cell lines.

  Antiviral research 19830901

• Efficiency and selectivity of (E)-5-(2-bromovinyl)-2'-deoxyuridine and some other 5-substituted 2'-deoxypyrimidine nucleosides as anti-herpes agents.

  Antiviral research 19820501

• Antiviral activity of 5-methylthiomethyl-2'-deoxyuridine and other 5-substituted 2'-deoxyuridines.

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