451492-95-8 | Av-412

Packsize	Purity	Availability	Price	Discounted Price
10mg	≥98%(HPLC)	in stock	$349.00	$245.00
50mg	≥98%(HPLC)	in stock	$948.00	$664.00
250mg	≥98%(HPLC)	in stock	$4,091.00	$2,864.00

Description

• Catalog Number: AG20761
• Chemical Name: Av-412
• CAS Number: 451492-95-8
• Molecular Formula: C27H28ClFN6O
• Molecular Weight: 507.0022
• MDL Number: MFCD16038939
• SMILES: C=CC(=O)Nc1cc2c(ncnc2cc1C#CC(N1CCN(CC1)C)(C)C)Nc1ccc(c(c1)Cl)F

Computed Properties

• Complexity: 850
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 36
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 7
• XLogP3: 4.5

Literature

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• Ubiquitination and downregulation of ErbB2 and estrogen receptor-alpha by kinase inhibitor MP-412 in human breast cancer cells.

  Journal of cellular biochemistry 20110901

• Antitumor activity of a dual epidermal growth factor receptor and ErbB2 kinase inhibitor MP-412 (AV-412) in mouse xenograft models.

  Cancer science 20090801

• Pharmacological characterization of MP-412 (AV-412), a dual epidermal growth factor receptor and ErbB2 tyrosine kinase inhibitor.

  Cancer science 20071201