465-21-4 | Bufalin

Packsize	Purity	Availability	Price	Discounted Price
5mg	≥98%	in stock	$74.00	$52.00
10mg	≥98%	in stock	$129.00	$90.00
25mg	≥98%	in stock	$283.00	$198.00
50mg	98% (HPLC)	in stock	$366.00	$257.00
250mg	98% (HPLC)	in stock	$1,439.00	$1,007.00

Description

• Catalog Number: AI50723
• Chemical Name: Bufalin
• CAS Number: 465-21-4
• Molecular Formula: C23H32O4
• Molecular Weight: 372.4978
• MDL Number: MFCD00056525
• SMILES: O[C@H]1CC[C@H]2[C@@H](C1)CC[C@H]1[C@@H]2CC[C@]2([C@@]1(O)CC[C@H]2c1ccc(=O)oc1)C

Computed Properties

• Complexity: 741
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 8
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 3.2

Literature

• Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects.

  Toxicology letters 20180915

• Bufalin induces apoptosis in vitro and has Antitumor activity against human lung cancer xenografts in vivo.

  Environmental toxicology 20170401

• Bufalin inhibits migration and invasion in human hepatocellular carcinoma SK-Hep1 cells through the inhibitions of NF-kB and matrix metalloproteinase-2/-9-signaling pathways.

  Environmental toxicology 20150101

• A novel cell-based high-throughput screen for inhibitors of HIV-1 gene expression and budding identifies the cardiac glycosides.

  The Journal of antimicrobial chemotherapy 20140401

• A bufadienolide derived androgen receptor antagonist with inhibitory activities against prostate cancer cells.

  Chemico-biological interactions 20140125

• Bufalin-inhibited migration and invasion in human osteosarcoma U-2 OS cells is carried out by suppression of the matrix metalloproteinase-2, ERK, and JNK signaling pathways.

  Environmental toxicology 20140101

• Interaction of digitalis-like compounds with p-glycoprotein.

  Toxicological sciences : an official journal of the Society of Toxicology 20130201

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• Ultrasound-assisted extraction of three bufadienolides from Chinese medicine ChanSu.

  Ultrasonics sonochemistry 20121101

• AKT serine/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells.

  International journal of oncology 20121101

• Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis.

  European journal of pharmacology 20121005

• Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells.

  Journal of cancer research and clinical oncology 20120801

• The novel antidote Bezoar Bovis prevents the cardiotoxicity of Toad (Bufo bufo gargarizans Canto) Venom in mice.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120701

• [Study on proteomics of Hela cell apoptosis in bufalin-induced human cervical carcinoma].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120701

• [A comparison study of pharmacokinetics between bufalin-loaded bovine serum albumin nanoparticles and bufalin in rats].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20120601

• Natural compounds inhibiting the replication of Porcine reproductive and respiratory syndrome virus.

  Antiviral research 20120501

• Natriuretic effect of bufalin in isolated rat kidneys involves activation of the Na+-K+-ATPase-Src kinase pathway.

  American journal of physiology. Renal physiology 20120415

• Cardenolides and bufadienolides as hormones: what is missing?

  American journal of physiology. Renal physiology 20120415

• Attenuation of glomerular filtration barrier damage in adriamycin-induced nephropathic rats with bufalin: an antiproteinuric agent.

  The Journal of steroid biochemistry and molecular biology 20120401

• Bufalin induces G0/G1 phase arrest through inhibiting the levels of cyclin D, cyclin E, CDK2 and CDK4, and triggers apoptosis via mitochondrial signaling pathway in T24 human bladder cancer cells.

  Mutation research 20120401

• Inhibitory effect of bufalin and cinobufagin on steroidogenesis via the activation of ERK in human adrenocortical cells.

  British journal of pharmacology 20120301

• Interacting impacts of invasive plants and invasive toads on native lizards.

  The American naturalist 20120301

• Secohellebrigeninamide.

  Acta crystallographica. Section E, Structure reports online 20120301

• Formation of new high density glycogen-microtubule structures is induced by cardiac steroids.

  The Journal of biological chemistry 20120224

• Bufalin enhances the anti-proliferative effect of sorafenib on human hepatocellular carcinoma cells through downregulation of ERK.

  Molecular biology reports 20120201

• Induction of cytochrome P450 3A by Shexiang Baoxin Pill and its main components.

  Chemico-biological interactions 20120125

• Endogenous ouabain regulates cell viability.

  American journal of physiology. Cell physiology 20120115

• Bufalin induces apoptosis through activation of both the intrinsic and extrinsic pathways in human bladder cancer cells.

  Oncology reports 20120101

• Bufalin induces lung cancer cell apoptosis via the inhibition of PI3K/Akt pathway.

  International journal of molecular sciences 20120101

• 'The Lower Threshold' phenomenon in tumor cells toward endogenous digitalis-like compounds: Responsible for tumorigenesis?

  Journal of carcinogenesis 20120101

• Bufalin, a traditional oriental medicine, induces apoptosis in human cancer cells.

  Asian Pacific journal of cancer prevention : APJCP 20120101

• Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling.

  International journal of nephrology 20120101

• Triggering apoptotic death of human malignant melanoma a375.s2 cells by bufalin: involvement of caspase cascade-dependent and independent mitochondrial signaling pathways.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Bufalin-loaded mPEG-PLGA-PLL-cRGD nanoparticles: preparation, cellular uptake, tissue distribution, and anticancer activity.

  International journal of nanomedicine 20120101

• Bufalin induces the apoptosis of acute promyelocytic leukemia cells via the downregulation of survivin expression.

  Acta haematologica 20120101

• Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research.

  PloS one 20120101

• The central mechanism underlying hypertension: a review of the roles of sodium ions, epithelial sodium channels, the renin-angiotensin-aldosterone system, oxidative stress and endogenous digitalis in the brain.

  Hypertension research : official journal of the Japanese Society of Hypertension 20111101

• The Na(+)/Ca(2+)-exchanger: an essential component in the mechanism governing cardiac steroid-induced slow Ca(2+) oscillations.

  Cell calcium 20111101

• [Inhibitory effect of total bufadienolides from toad venom against H22 tumor in mice and their metabolites].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111101

• Bioadhesion and enhanced bioavailability by wheat germ agglutinin-grafted lipid nanoparticles for oral delivery of poorly water-soluble drug bufalin.

  International journal of pharmaceutics 20111031

• Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation.

  Free radical biology & medicine 20111001

• Novel microbial transformation of resibufogenin by Fusarium solani.

  Journal of Asian natural products research 20110901

• Effects of bufalin on the proliferation of human choriocarcinoma cells.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20110801

• Bufalin and cinobufagin induce apoptosis of human hepatocellular carcinoma cells via Fas- and mitochondria-mediated pathways.

  Cancer science 20110501

• Bufadienolide compounds sensitize human breast cancer cells to TRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway.

  Apoptosis : an international journal on programmed cell death 20110401

• Na+/K+-ATPase α3 mediates sensitivity of hepatocellular carcinoma cells to bufalin.

  Oncology reports 20110301

• Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor.

  International immunopharmacology 20110301

• Bufalin Induces Reactive Oxygen Species Dependent Bax Translocation and Apoptosis in ASTC-a-1 Cells.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Cardiac glycosides are potent inhibitors of interferon-β gene expression.

  Nature chemical biology 20110101

• Ex vivo activity of cardiac glycosides in acute leukaemia.

  PloS one 20110101

• Bufalin inhibits platelet-derived growth factor-BB-induced mesangial cell proliferation through mediating cell cycle progression.

  Biological & pharmaceutical bulletin 20110101

• Optimized antimicrobial and antiproliferative activities of titanate nanofibers containing silver.

  International journal of nanomedicine 20110101

• Selective inhibition of the cellular sodium pump by emicymarin and 14ß anhydroxy bufadienolides.

  Steroids 20101212

• Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action.

  Cytotechnology 20101201

• Analysis of the bioactive constituents of ChanSu in rat plasma by high performance liquid chromatography with mass spectrometric detection.

  Journal of pharmaceutical and biomedical analysis 20101102

• Retraction of 'Effect of bufalin on proliferation and apoptosis of human non-small cell lung cancer A549 Cell. Zhongguo Fei Ai Za Zhi, 2010, 13(9): 841-845'.

  Zhongguo fei ai za zhi = Chinese journal of lung cancer 20101101

• Delisheng, a Chinese medicinal compound, exerts anti-proliferative and pro-apoptotic effects on HepG2 cells through extrinsic and intrinsic pathways.

  Molecular biology reports 20101001

• [Bufalin induces apoptosis in osteosarcoma U-2OS and U-2OS methotrexate 300-resistant cell lines in vitro].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20101001

• Wheat germ agglutinin-grafted lipid nanoparticles: preparation and in vitro evaluation of the association with Caco-2 monolayers.

  International journal of pharmaceutics 20100915

• Cytotoxic profile of natural and some modified bufadienolides from toad Rhinella schneideri parotoid gland secretion.

  Toxicon : official journal of the International Society on Toxinology 20100901

• [Effect of Bufalin on proliferation and apoptosis of human non-small cell lung cancer A549 cell].

  Zhongguo fei ai za zhi = Chinese journal of lung cancer 20100901

• Preparative separation of four major bufadienolides from the Chinese traditional medicine, Chansu, using high-speed counter-current chromatography.

  Natural product communications 20100701

• Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+ -ATPase.

  Acta pharmacologica Sinica 20100601

• Preparative separation and purification of bufadienolides from Chinese traditional medicine of ChanSu using high-speed counter-current chromatography.

  Journal of separation science 20100501

• Ouabain attenuates cardiotoxicity induced by other cardiac steroids.

  British journal of pharmacology 20100501

• Titanate-silica mesostructured nanocables: synthesis, structural analysis and biomedical applications.

  Nanotechnology 20100210

• Na, K-ATPase: Ubiquitous Multifunctional Transmembrane Protein and its Relevance to Various Pathophysiological Conditions.

  Journal of clinical medicine research 20100201

• An improved formulation screening and optimization method applied to the development of a self-microemulsifying drug delivery system.

  Chemical & pharmaceutical bulletin 20100101

• Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines.

  Chinese medicine 20100101

• Inhibition of P-glycoprotein at the blood-brain barrier by phytochemicals derived from traditional Chinese medicine.

  Cancer genomics & proteomics 20100101

• Pheromone-induced life-history shifts A novel approach to controlling invasive toads.

  Communicative & integrative biology 20100101

• Anti-hepatitis B virus activities of cinobufacini and its active components bufalin and cinobufagin in HepG2.2.15 cells.

  Biological & pharmaceutical bulletin 20100101

• Human tumor cell sensitivity to oleandrin is dependent on relative expression of Na+, K+ -ATPase subunitst.

  Journal of experimental therapeutics & oncology 20100101

• Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer.

  Cancer 20091115

• [Determination of plasma protein binding rate of bufalin].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091101

• Preparation and evaluation of lyophilized liposome-encapsulated bufadienolides.

  Drug development and industrial pharmacy 20090901

• Sudden death associated with intravenous injection of toad extract.

  Forensic science international 20090701

• Bufalin inhibits CYP3A4 activity in vitro and in vivo.

  Acta pharmacologica Sinica 20090501

• Microarray and biochemical analysis of bufalin-induced apoptosis of HL-60 Cells.

  Biotechnology letters 20090401

• FLIM and emission spectral analysis of caspase-3 activation inside single living cell during anticancer drug-induced cell death.

  European biophysics journal : EBJ 20090401

• Increased nuclear expression and transactivation of vitamin D receptor by the cardiotonic steroid bufalin in human myeloid leukemia cells.

  The Journal of steroid biochemistry and molecular biology 20090401

• [Effects of Bufalin on SYK and CBL family proteins in induction of HL-60 cell apoptosis].

  Zhongguo shi yan xue ye xue za zhi 20090201

• Simultaneous quantification of seven major bufadienolides in three traditional Chinese medicinal preparations of chansu by HPLC-DAD.

  Natural product communications 20090201

• PI3K/Akt is involved in bufalin-induced apoptosis in gastric cancer cells.

  Anti-cancer drugs 20090101

• Traditional Chinese Medicines in the treatment of hepatocellular cancers: a systematic review and meta-analysis.

  Journal of experimental & clinical cancer research : CR 20090101

• Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis.

  PloS one 20090101

• Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and -independent human prostate cancer cells.

  Cancer science 20081201

• [The influence of bortezomib on HL-60 cell function induced by all-trans retinoic acid plus bufalin and its mechanism].

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20081201

• Agents from amphibians with anticancer properties.

  Anti-cancer drugs 20081101

• Characterization of in vivo metabolites of toad venom using liquid chromatography-mass spectrometry.

  Journal of chromatographic science 20080701

• [Determination of apparent aqueous solubility and apparent oil-water partition coefficients of three bufadienolides composition].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080601

• Bufalin induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells.

  International journal of molecular medicine 20080501

• Simultaneous determination of three bufadienolides in rat plasma after intravenous administration of bufadienolides extract by ultra performance liquid chromatography electrospray ionization tandem mass spectrometry.

  Analytica chimica acta 20080310

• [Determination of three bufogenins in toad venom using reversed-phase high performance liquid chromatography].

  Se pu = Chinese journal of chromatography 20080301

• Up-regulation of the Cbl family of ubiquitin ligases is involved in ATRA and bufalin-induced cell adhesion but not cell differentiation.

  Biochemical and biophysical research communications 20080227

• Effect of Chinese medicines Chan Su and Lu-Shen-Wan on serum digoxin measurement by Digoxin III, a new digoxin immunoassay.

  Therapeutic drug monitoring 20080201

• Preparative isolation of bufalin and cinobufagin from Chinese traditional medicine ChanSu.

  Journal of chromatographic science 20080101

• Gene expression in Pre-MBT embryos and activation of maternally-inherited program of apoptosis to be executed at around MBT as a fail-safe mechanism in Xenopus early embryogenesis.

  Gene regulation and systems biology 20080101

• Diverse biological responses to different cardiotonic steroids.

  Pathophysiology : the official journal of the International Society for Pathophysiology 20071201

• Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside.

  Integrative cancer therapies 20071201

• Microbial transformation of three bufadienolides by Nocardia sp. and some insight for the cytotoxic structure-activity relationship (SAR).

  Bioorganic & medicinal chemistry letters 20071115

• Simultaneous determination of five main active bufadienolides of Chan Su in rat plasma by liquid chromatography tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071115

• Role of endosomal Na+-K+-ATPase and cardiac steroids in the regulation of endocytosis.

  American journal of physiology. Cell physiology 20070901

• Membrane dielectric responses of bufalin-induced apoptosis in HL-60 cells detected by an electrorotation chip.

  Biotechnology letters 20070901

• Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth.

  American journal of physiology. Cell physiology 20070801

• Anti-tumor activities and apoptosis-regulated mechanisms of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice.

  World journal of gastroenterology 20070628

• Study of the determination and pharmacokinetics of bufadienolides in dog's plasma after administration of Liu-Shen-Wan by high performance liquid chromatography time-of-flight mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615

• Electrokinetic measurements of dielectric properties of membrane for apoptotic HL-60 cells on chip-based device.

  Biomedical microdevices 20070601

• Bufalin induces apoptosis in human osteosarcoma U-2OS and U-2OS methotrexate300-resistant cell lines.

  Acta pharmacologica Sinica 20070501

• [Inhibition action of bufalin on human transplanted hepatocellular tumor and its effects on expressions of Bcl-2 and Bax proteins in nude mice].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20070301

• [Effect of bufalin-inducing apoptosis on Bcl-2 and PKC in HL-60 cells].

  Zhongguo shi yan xue ye xue za zhi 20070201

• Involvement of Tiam1 in apoptosis induced by bufalin in HeLa cells.

  Anticancer research 20070101

• Short-term effects of cardiac steroids on intracellular membrane traffic in neuronal NT2 cells.

  Cellular and molecular biology (Noisy-le-Grand, France) 20061230

• Characterization of in vitro metabolites of toad venom using high-performance liquid chromatography and liquid chromatography-mass spectrometry.

  Biomedical chromatography : BMC 20061201

• [Enhancement of all-trans retinoic acid-induced differentiation by bufalin in primary culture of acute promyelocytic leukemia cells].

  Zhonghua nei ke za zhi 20060401

• Oleandrin-mediated oxidative stress in human melanoma cells.

  Journal of experimental therapeutics & oncology 20060101

• [Downregulation of Bcl-2 and survivin expression and release of Smac/DIABLO involved in bufalin-induced HL-60 cell apoptosis].

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20060101

• Enhancement of ligand-dependent vitamin D receptor transactivation by the cardiotonic steroid bufalin.

  Biochemical pharmacology 20051115

• Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an 'in vitro' replicative system.

  Antiviral research 20051101

• Bufalin induces apoptosis and the G0/G1 cell cycle arrest of endometriotic stromal cells: a promising agent for the treatment of endometriosis.

  Molecular human reproduction 20051101

• Changing characteristics of the TDx digoxin II assay in detecting bufadienolides in a traditional Chinese medicine: for better or worse?

  Therapeutic drug monitoring 20051001

• Na/K-ATPase, endogenous digitalis like compounds and cancer development -- a hypothesis.

  Frontiers in bioscience : a journal and virtual library 20050901

• Substrate specificity for the 12beta-hydroxylation of bufadienolides by Alternaria alternata.

  Journal of biotechnology 20050525

• Microbial hydroxylation of bufalin by Cunninghamella blakesleana and Mucor spinosus.

  Journal of natural products 20050401

• Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells.

  The Journal of biological chemistry 20050107

• Inhibitory effects of bufadienolides on interleukin-6 in MH-60 cells.

  Journal of natural products 20041201

• Characterization of the neutralizing activity of digoxin-specific Fab toward ouabain-like steroids.

  The Journal of pharmacology and experimental therapeutics 20040701

• [Basic studies for the development of anticancer, antidementia, and taste modifier drugs].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040701

• Simultaneous determination of four bufadienolides in human liver by high-performance liquid chromatography.

  Biomedical chromatography : BMC 20040601

• Novel cytotoxic bufadienolides derived from bufalin by microbial hydroxylation and their structure-activity relationships.

  The Journal of steroid biochemistry and molecular biology 20040601

• Bufalin influences the repair of X-ray-induced DNA breaks in Chinese hamster cells.

  DNA repair 20031209

• [Dynamic effect of low frequency complex impulse current on transdermal absorption of secretio bufonis].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20031001

• [Advances in the study of tumor angiogenesis and anti-angiogenic Chinese herbal drugs].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030501

• Study on mechanism of action of Chinese medicine Chan Su: dose-dependent biphasic production of nitric oxide in trophoblastic BeWo cells.

  Clinica chimica acta; international journal of clinical chemistry 20030401

• Nongastric H,K-ATPase: structure and functional properties.

  Annals of the New York Academy of Sciences 20030401

• Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells.

  The Prostate 20030201

• Effects of Chan Su, a traditional Chinese medicine, on the calcium transients of isolated cardiomyocytes: cardiotoxicity due to more than Na, K-ATPase blocking.

  Life sciences 20021227

• Three-dimensional quantitative structure-activity relationship analysis of ligand binding to human sequence antidigoxin monoclonal antibodies using comparative molecular field analysis.

  Journal of medicinal chemistry 20020718

• WT1 downregulation during K562 cell differentiation and apoptosis induced by bufalin.

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20020701

• A comparative study of genotoxic effects of anti-topoisomerase II drugs ICRF-193 and bufalin in Chinese hamster ovary cells.

  Mutation research 20020325

• Studies on toad venom (3): effect of metals on the quality of toad venom torrefied on a metal plate.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20020101

• Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells.

  Blood cells, molecules & diseases 20020101

• Testing the SCE mechanism with non-poisoning topoisomerase II inhibitors.

  Mutation research 20011018

• Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.

  Journal of natural products 20010901

• Distinct PKC isozymes regulate bufalin-induced differentiation and apoptosis in human monocytic cells.

  American journal of physiology. Cell physiology 20010301

• Determination of bufalin-like immunoreactivity in serum of humans and rats by time-resolved fluoroimmunoassay for using a monoclonal antibody.

  Life sciences 20010126

• Digitoxin medication and cancer; case control and internal dose-response studies.

  BMC cancer 20010101

• [Preliminary study on apoptosis of human leukemic cells induced by bufalin].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010101

• ERK signaling mediates the induction of inflammatory cytokines by bufalin in human monocytic cells.

  American journal of physiology. Cell physiology 20000301

• Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia cells.

  Leukemia research 19950801