474-25-9 | (3α,5β,7α)-3,7-Dihydroxycholan-24-oic acid

Packsize	Purity	Availability	Price	Discounted Price
5g	97%	in stock	$16.00	$11.00
10g	97%	in stock	$21.00	$15.00
25g	97%	in stock	$26.00	$18.00

Description

• Catalog Number: AB51823
• Chemical Name: (3α,5β,7α)-3,7-Dihydroxycholan-24-oic acid
• CAS Number: 474-25-9
• Molecular Formula: C24H40O4
• Molecular Weight: 392.572
• MDL Number: MFCD00064142
• SMILES: O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C

Computed Properties

• Complexity: 605
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 10
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 4
• XLogP3: 4.9

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  Neurologia i neurochirurgia polska 20110101

• Structural determinants for transport across the intestinal bile acid transporter using C-24 bile acid conjugates.

  Molecular pharmaceutics 20101206

• A predictive ligand-based Bayesian model for human drug-induced liver injury.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Protective effect of bile acids on the onset of fructose-induced hepatic steatosis in mice.

  Journal of lipid research 20101201

• Endocrine, metabolic, nutritional, and toxic disorders leading to dementia.

  Annals of Indian Academy of Neurology 20101201

• Structural requirements of the ASBT by 3D-QSAR analysis using aminopyridine conjugates of chenodeoxycholic acid.

  Bioconjugate chemistry 20101117

• Application of near infrared spectroscopy for rapid analysis of intermediates of Tanreqing injection.

  Journal of pharmaceutical and biomedical analysis 20101102

• Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice.

  Journal of lipid research 20101101

• Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis.

  Gastroenterology 20101101

• The influence of NaCl on hydrophobicity of selected, pharmacologically active bile acids expressed with chromatographic retention index and critical micellar concentration.

  Colloids and surfaces. B, Biointerfaces 20101101

• Inflammatory mediators of esophagitis alter p27 Kip1 expression in esophageal epithelial cells.

  Journal of pediatric gastroenterology and nutrition 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Analysis of serum bile acids by isotope dilution-mass spectrometry to assess the performance of routine total bile acid methods.

  Annals of clinical biochemistry 20101101

• Cerebrotendinous xanthomatosis: a treatable hereditary neuro-metabolic disease.

  Clinics (Sao Paulo, Brazil) 20101101

• A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices.

  Lab on a chip 20101021

• Quantification of the 15 major human bile acids and their precursor 7α-hydroxy-4-cholesten-3-one in serum by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101015

• Steroid degradation genes in Comamonas testosteroni TA441: Isolation of genes encoding a Δ4(5)-isomerase and 3α- and 3β-dehydrogenases and evidence for a 100 kb steroid degradation gene hot spot.

  The Journal of steroid biochemistry and molecular biology 20101001

• Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid.

  Journal of bacteriology 20101001

• Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism.

  Hepatology (Baltimore, Md.) 20101001

• Modelling phase transition kinetics of chenodeoxycholic acid with the Runge-Kutta method.

  Journal of pharmaceutical and biomedical analysis 20100921

• Simple and practical derivatization procedure for enhanced detection of carboxylic acids in liquid chromatography-electrospray ionization-tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20100905

• Molecular genetic and bile acid profiles in two Japanese patients with 3beta-hydroxy-DELTA5-C27-steroid dehydrogenase/isomerase deficiency.

  Pediatric research 20100901

• Two time-point assessment of bile acid kinetics in humans using stable isotopes.

  Isotopes in environmental and health studies 20100901

• Construction of confidence regions for isotopic abundance patterns in LC/MS data sets for rigorous determination of molecular formulas.

  Analytical chemistry 20100901

• [Chemical constituents of bear bile].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100901

• Synthesis and in vitro evaluation of potential sustained release prodrugs via targeting ASBT.

  International journal of pharmaceutics 20100830

• Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway.

  Journal of lipid research 20100801

• Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.

  Journal of lipid research 20100801

• A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes.

  Journal of lipid research 20100801

• 3β-hydroxy-Δ⁵-C₂₇-steroid dehydrogenase/isomerase deficiency in a patient who underwent oral bile acid therapy for 10 years and delivered two healthy infants.

  Pediatrics international : official journal of the Japan Pediatric Society 20100801

• Effects of DCA on Cell Cycle Proteins in Colonocytes.

  Journal of the Korean Society of Coloproctology 20100801

• Synthesis of bile acid derivatives and in vitro cytotoxic activity with pro-apoptotic process on multiple myeloma (KMS-11), glioblastoma multiforme (GBM), and colonic carcinoma (HCT-116) human cell lines.

  European journal of medicinal chemistry 20100701

• Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro.

  Aquatic toxicology (Amsterdam, Netherlands) 20100701

• Bile acid changes after high-dose ursodeoxycholic acid treatment in primary sclerosing cholangitis: Relation to disease progression.

  Hepatology (Baltimore, Md.) 20100701

• Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes.

  Aging 20100701

• Farnesoid X receptor activation prevents the development of vascular calcification in ApoE-/- mice with chronic kidney disease.

  Circulation research 20100625

• [Effects of bile acids on expression of interleukin-6 and cell viability in QBC939 cell line].

  Zhonghua wai ke za zhi [Chinese journal of surgery] 20100615

• Determination of multicomponent contents in Calculus bovis by ultra-performance liquid chromatography-evaporative light scattering detection and its application for quality control.

  Journal of separation science 20100601

• Hydrophobicity and haemolytic potential of oxo derivatives of cholic, deoxycholic and chenodeoxycholic acids.

  Steroids 20100601

• Bile acids: short and long term effects in the intestine.

  Scandinavian journal of gastroenterology 20100601

• Titration of bile acid supplements in 3beta-hydroxy-Delta 5-C27-steroid dehydrogenase/isomerase deficiency.

  Journal of pediatric gastroenterology and nutrition 20100601

• Neuropathy, retinopathy, and glucose-lowering treatments.

  Diabetes care 20100601

• Characterization of porcine pregnane X receptor, farnesoid X receptor and their splice variants.

  Experimental biology and medicine (Maywood, N.J.) 20100601

• Pharmacotherapy of cholestatic liver diseases.

  Journal of digestive diseases 20100601

• NMR characterization of the interaction of the Salmonella type III secretion system protein SipD and bile salts.

  Biochemistry 20100518

• Regulation of bile acid synthesis by fat-soluble vitamins A and D.

  The Journal of biological chemistry 20100507

• Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice.

  Journal of hepatology 20100501

• Metabonomics study of urine and plasma in depression and excess fatigue rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry.

  Molecular bioSystems 20100501

• Isolation and characterization of a bile acid inducible 7alpha-dehydroxylating operon in Clostridium hylemonae TN271.

  Anaerobe 20100401

• Ursodeoxycholic acid switches oxaliplatin-induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53-caspase 8 pathway in HepG2 hepatocellular carcinoma.

  International journal of cancer 20100401

• FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats.

  Journal of lipid research 20100401

• Bile acid-activated receptors in the treatment of dyslipidemia and related disorders.

  Progress in lipid research 20100401

• Regulation of VDR expression in rat and human intestine and liver--consequences for CYP3A expression.

  Toxicology in vitro : an international journal published in association with BIBRA 20100401

• alpha(1)-fetoprotein transcription factor (FTF)/liver receptor homolog-1 (LRH-1) is an essential lipogenic regulator.

  Biochimica et biophysica acta 20100401

• Salivary chenodeoxycholic acid and its glycine-conjugate: their determination method using LC-MS/MS and variation of their concentrations with increased saliva flow rate.

  Steroids 20100401

• Regulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids.

  Journal of hepatology 20100401

• Cerebrotendinous xanthomatosis presenting with severe externalized disorder: improvement after one year of treatment with chenodeoxycholic Acid.

  CNS spectrums 20100401

• Identification of farnesoid X receptor modulators by a fluorescence polarization-based interaction assay.

  Analytical biochemistry 20100315

• Oleanolic acid is a selective farnesoid X receptor modulator.

  Phytotherapy research : PTR 20100301

• Impacts of different promoters on the mammalian one-hybrid assay for detecting nuclear receptor agonists.

  Analytical and bioanalytical chemistry 20100301

• Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1).

  Xenobiotica; the fate of foreign compounds in biological systems 20100301

• Past, present and future therapeutics for cerebellar ataxias.

  Current neuropharmacology 20100301

• Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells.

  The Journal of biological chemistry 20100219

• Upregulation of early growth response factor-1 by bile acids requires mitogen-activated protein kinase signaling.

  Toxicology and applied pharmacology 20100215

• Cerebrospinal fluid steroidomics: are bioactive bile acids present in brain?

  The Journal of biological chemistry 20100212

• Effects of chenodeoxycholate and a bile acid sequestrant, colesevelam, on intestinal transit and bowel function.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20100201

• Regulation of diurnal variation of cholesterol 7alpha-hydroxylase (CYP7A1) activity in healthy subjects.

  Physiological research 20100101

• Variable clinical spectrum of the most common inborn error of bile acid metabolism--3beta-hydroxy-Delta 5-C27-steroid dehydrogenase deficiency.

  Journal of pediatric gastroenterology and nutrition 20100101

• High performance liquid chromatography-tandem mass spectrometry for the determination of bile acid concentrations in human plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100101

• Plasma bile acid concentrations in patients with human immunodeficiency virus infection receiving protease inhibitor therapy: possible implications for hepatotoxicity.

  Pharmacotherapy 20100101

• Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells.

  Acta pharmacologica Sinica 20100101

• Metabolism of bile salts in mice influences spore germination in Clostridium difficile.

  PloS one 20100101

• Bile acids induce cdx2 expression through the farnesoid x receptor in gastric epithelial cells.

  Journal of clinical biochemistry and nutrition 20100101

• Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection.

  BMC medicine 20100101

• Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites.

  BMC evolutionary biology 20100101

• Identification of novel pathogenicity loci in Clostridium perfringens strains that cause avian necrotic enteritis.

  PloS one 20100101

• Fenofibrate in primary biliary cirrhosis: a pilot study.

  The open cardiovascular medicine journal 20100101

• Multi-parametric neuroimaging evaluation of cerebrotendinous xanthomatosis and its correlation with neuropsychological presentations.

  BMC neurology 20100101

• Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1.

  Drug metabolism and pharmacokinetics 20100101

• Metabolic bone disease in lion cubs at the London Zoo in 1889: the original animal model of rickets.

  Journal of biomedical science 20100101

• Plasma bile acids are not associated with energy metabolism in humans.

  Nutrition & metabolism 20100101

• Analyzing the regulation of metabolic pathways in human breast cancer.

  BMC medical genomics 20100101

• The Role of PPARα Activation in Liver and Muscle.

  PPAR research 20100101

• A novel mutation in the sterol 27-hydroxylase gene of a woman with autosomal recessive cerebrotendinous xanthomatosis.

  Orphanet journal of rare diseases 20100101

• The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice.

  PloS one 20100101

• Bile acid-induced virulence gene expression of Vibrio parahaemolyticus reveals a novel therapeutic potential for bile acid sequestrants.

  PloS one 20100101

• Liver X receptor agonist methyl-3β-hydroxy-5α,6α-epoxycholanate attenuates atherosclerosis in apolipoprotein E knockout mice without increasing plasma triglyceride.

  Pharmacology 20100101

• Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting.

  PloS one 20100101

• Antimicrobial peptides in gastrointestinal inflammation.

  International journal of inflammation 20100101

• A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity.

  PloS one 20100101

• Deciphering the nuclear bile acid receptor FXR paradigm.

  Nuclear receptor signaling 20100101

• Microbial induction of immunity, inflammation, and cancer.

  Frontiers in physiology 20100101

• Cerebrotendinous xanthomatosis associated with immune thrombocytopenia.

  BMJ case reports 20100101

• Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity.

  Journal of medicinal chemistry 20091224

• The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria.

  American journal of physiology. Renal physiology 20091201

• Detection of Helicobacter hepaticus in human bile samples of patients with biliary disease.

  Helicobacter 20091201

• Developments in bile acid kinetic measurements using (13)C and (2)H: 10(5) times improved sensitivity during the last 40 years.

  Isotopes in environmental and health studies 20091201

• Determination of critical micellar concentrations of two monoketo derivatives of cholic acid.

  Colloids and surfaces. B, Biointerfaces 20091101

• Effect of mitiglinide on Streptozotocin-induced experimental type 2 diabetic rats: a urinary metabonomics study based on ultra-performance liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091101

• CFTR expression but not Cl- transport is involved in the stimulatory effect of bile acids on apical Cl-/HCO3- exchange activity in human pancreatic duct cells.

  Pancreas 20091101

• Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration.

  Diabetes care 20091101

• Case Report: Cerebrotendinous xanthomatosis.

  The Indian journal of radiology & imaging 20091101

• Hepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine.

  The Journal of biological chemistry 20091016

• Modulation of bile acid metabolism by 1alpha-hydroxyvitamin D3 administration in mice.

  Drug metabolism and disposition: the biological fate of chemicals 20091001

• Albumin dialysis molecular adsorbents recirculating system: impact of dialysate albumin concentration on detoxification efficacy.

  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20091001

• Cerebrotendinous xanthomatosis: a treatable neurodegenerative disease.

  The Journal of the Association of Physicians of India 20091001

• Fluorescence properties of trans-ethyl-p-(dimethylamino) cinnamate in presence of bile acid host.

  Journal of photochemistry and photobiology. B, Biology 20090904

• The mechanism of the cholesterol-lowering effect of water-insoluble fish protein in ovariectomised rats.

  The British journal of nutrition 20090901

• The role of transporters in the pharmacokinetics of orally administered drugs.

  Pharmaceutical research 20090901

• Characterization of the contents of ascending colon to which drugs are exposed after oral administration to healthy adults.

  Pharmaceutical research 20090901

• Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes.

  American journal of physiology. Gastrointestinal and liver physiology 20090901

• Effects of essential fatty acid deficiency on enterohepatic circulation of bile salts in mice.

  American journal of physiology. Gastrointestinal and liver physiology 20090901

• Cerebrotendinous xanthomatosis (CTX): a treatable lipid storage disease.

  Pediatric endocrinology reviews : PER 20090901

• Nutritional approaches to prevention and treatment of gallstones.

  Alternative medicine review : a journal of clinical therapeutic 20090901

• Ferrocene-beta-cyclodextrin conjugates: synthesis, supramolecular behavior, and use as electrochemical sensors.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20090817

• Metabonomics study of atherosclerosis rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry.

  Talanta 20090815

• Inhibition of nucleostemin upregulates CDX2 expression in HT29 cells in response to bile acid exposure: implications in the pathogenesis of Barrett's esophagus.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20090801

• Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells.

  Journal of cellular and molecular medicine 20090801

• Relative inhibitory activity of bile acids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation, and chenodeoxycholic acid inhibition of tumour promotion in mouse skin two-stage carcinogenesis.

  The Journal of pharmacy and pharmacology 20090801

• Oromandibular dystonia as a complication of cerebrotendinous xanthomatosis.

  Movement disorders : official journal of the Movement Disorder Society 20090715

• Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease.

  World journal of gastroenterology 20090707

• Bile acid aspiration in suspected ventilator-associated pneumonia.

  Chest 20090701

• Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP).

  American journal of physiology. Gastrointestinal and liver physiology 20090701

• Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner.

  Molecular nutrition & food research 20090701

• Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver.

  Biopharmaceutics & drug disposition 20090701

• Monoketocholate can decrease transcellular permeation of methotrexate across Caco-2 cell monolayers and reduce its intestinal absorption in rat.

  The Journal of pharmacy and pharmacology 20090701

• Association between farnesoid X receptor expression and cell proliferation in estrogen receptor-positive luminal-like breast cancer from postmenopausal patients.

  Breast cancer research and treatment 20090601

• Absence of glycochenodeoxycholic acid (GCDCA) in human bile is an indication of cholestasis: a 1H MRS study.

  NMR in biomedicine 20090601

• Ligand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selection.

  Drug metabolism and disposition: the biological fate of chemicals 20090601

• Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans.

  Pharmacogenetics and genomics 20090601

• Differentiated CaCo-2 cells as an in-vitro model to evaluate de-novo apolipoprotein A-I production in the small intestine.

  European journal of gastroenterology & hepatology 20090601

• Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090512

• Efficacy on anaplastic thyroid carcinoma of valproic acid alone or in combination with doxorubicin, a synthetic chenodeoxycholic acid derivative, or lactacystin.

  International journal of oncology 20090501

• [Expression and regulation of megalin in gallbladder mucosa associated with cholesterol gallstone disease].

  Zhonghua yi xue za zhi 20090428

• Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation.

  Genes & development 20090415

• [The right medicine for cerebrotendinous xanthomatosis].

  Nederlands tijdschrift voor geneeskunde 20090411

• Bile acid ratio in diagnosis of intrahepatic cholestasis of pregnancy.

  American journal of perinatology 20090401

• FXR promotes endothelial cell motility through coordinated regulation of FAK and MMP-9.

  Arteriosclerosis, thrombosis, and vascular biology 20090401

• Conversion of cholic acid and chenodeoxycholic acid into their 7-oxo derivatives by Bacteroides intestinalis AM-1 isolated from human feces.

  FEMS microbiology letters 20090401

• Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium.

  Gastroenterology 20090401

• [Cerebrotendinous xanthomatosis: report of 4 patients].

  Actas dermo-sifiliograficas 20090401

• ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained.

  Gastroenterology 20090301

• Hematopoietically expressed homeobox is a target gene of farnesoid X receptor in chenodeoxycholic acid-induced liver hypertrophy.

  Hepatology (Baltimore, Md.) 20090301

• Cholesterol-dependent anaplasma phagocytophilum exploits the low-density lipoprotein uptake pathway.

  PLoS pathogens 20090301

• The farnesoid X receptor regulates transcription of 3beta-hydroxysteroid dehydrogenase type 2 in human adrenal cells.

  Molecular and cellular endocrinology 20090227

• Antiatherosclerotic effect of farnesoid X receptor.

  American journal of physiology. Heart and circulatory physiology 20090201

• Lake char (Salvelinus namaycush) olfactory neurons are highly sensitive and specific to bile acids.

  Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20090201

• Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines.

  The Journal of biological chemistry 20090130

• Effect of ursodeoxycholic acid on serum liver enzymes and bile acid metabolism in chronic active hepatitis C virus infection.

  Hepatology research : the official journal of the Japan Society of Hepatology 20090101

• Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.

  Hepatology (Baltimore, Md.) 20090101

• Novel zinc porphyrin sensitizers for dye-sensitized solar cells: synthesis and spectral, electrochemical, and photovoltaic properties.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20090101

• Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia.

  Journal of natural products 20090101

• Low retinol levels differentially modulate bile salt-induced expression of human and mouse hepatic bile salt transporters.

  Hepatology (Baltimore, Md.) 20090101

• Chronic diarrhea and juvenile cataracts: think cerebrotendinous xanthomatosis and treat.

  Pediatrics 20090101

• Bear bile: dilemma of traditional medicinal use and animal protection.

  Journal of ethnobiology and ethnomedicine 20090101

• Biphasic regulation of cell death and survival by hydrophobic bile acids in HCT116 cells.

  Nutrition and cancer 20090101

• Cefotaxime pharmacokinetics after oral application in the form of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanate microvesicles in rat.

  European journal of drug metabolism and pharmacokinetics 20090101

• Gliclazide reduces MKC intestinal transport in healthy but not diabetic rats.

  European journal of drug metabolism and pharmacokinetics 20090101

• Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells.

  BMC cancer 20090101

• Regulation of bile acid and cholesterol metabolism by PPARs.

  PPAR research 20090101

• Effect of 12-monoketocholic acid on modulation of analgesic action of morphine and tramadol.

  European journal of drug metabolism and pharmacokinetics 20090101

• Various techniques for the surgical treatment of common bile duct stones: a meta review.

  Gastroenterology research and practice 20090101

• Regulation of sulfotransferase and UDP-glucuronosyltransferase gene expression by the PPARs.

  PPAR research 20090101

• A new bile acid from the bile of Anser anser.

  Natural product research 20090101

• Erythropoietic protoporphyria.

  Orphanet journal of rare diseases 20090101

• A transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells.

  BMC genomics 20090101

• Functional and probiotic attributes of an indigenous isolate of Lactobacillus plantarum.

  PloS one 20090101

• Transport assays and permeability in pathogenic mycobacteria.

  Methods in molecular biology (Clifton, N.J.) 20090101

• 7alpha- and 12alpha-Hydroxysteroid dehydrogenases from Acinetobacter calcoaceticus lwoffii: a new integrated chemo-enzymatic route to ursodeoxycholic acid.

  Steroids 20081222

• The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor.

  Hepatology (Baltimore, Md.) 20081201

• Elevated cholesterol precursors other than cholestanol can also be a hallmark for CTX.

  Journal of inherited metabolic disease 20081201

• Physical and chemical factors influencing the germination of Clostridium difficile spores.

  Journal of applied microbiology 20081201

• Beta-glucans in the treatment of diabetes and associated cardiovascular risks.

  Vascular health and risk management 20081201

• Synthetic chenodeoxycholic acid derivative, HS-1200, induces apoptosis of human hepatoma cells via a mitochondrial pathway.

  Cancer letters 20081108

• Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity.

  Molecular endocrinology (Baltimore, Md.) 20081101

• beta-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes.

  American journal of physiology. Gastrointestinal and liver physiology 20081101

• Bile acids induce CCN2 production through p38 MAP kinase activation in human bronchial epithelial cells: a factor contributing to airway fibrosis.

  Respirology (Carlton, Vic.) 20081101

• Altered bile acid metabolism in childhood functional constipation: inactivation of secretory bile acids by sulfation in a subset of patients.

  Journal of pediatric gastroenterology and nutrition 20081101

• FXRalpha down-regulates LXRalpha signaling at the CETP promoter via a common element.

  Molecules and cells 20081031

• Association between fecal bile acids and colorectal cancer: a meta-analysis of observational studies.

  Yonsei medical journal 20081031

• Synthesis of sterically hindered phthalocyanines and their applications to dye-sensitized solar cells.

  Dalton transactions (Cambridge, England : 2003) 20081028

• Effect of coadsorbent on the photovoltaic performance of squaraine sensitized nanocrystalline solar cells.

  Nanotechnology 20081022

• A chenodeoxycholic derivative, HS-1200, induces apoptosis and cell cycle modulation via Egr-1 gene expression control on human hepatoma cells.

  Cancer letters 20081018

• Pyrazolidine-3,5-dione derivatives as potent non-steroidal agonists of farnesoid X receptor: virtual screening, synthesis, and biological evaluation.

  Bioorganic & medicinal chemistry letters 20081015

• Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid.

  Drug metabolism and disposition: the biological fate of chemicals 20081001

• New lithocholic and chenodeoxycholic piperazinylcarboxamides with antiproliferative and pro-apoptotic effects on human cancer cell lines.

  Bioorganic & medicinal chemistry 20080915

• The synthesis of MP-CDCA conjugates and dissolution kinetics of model cholesterol gallstones.

  Acta biomaterialia 20080901

• Bile acids repress E-cadherin through the induction of Snail and increase cancer invasiveness in human hepatobiliary carcinoma.

  Cancer science 20080901

• Effects of bile acids on pancreatic ductal bicarbonate secretion in guinea pig.

  Gut 20080801

• Critical micellar concentrations of keto derivatives of selected bile acids: thermodynamic functions of micelle formation.

  Colloids and surfaces. B, Biointerfaces 20080715

• Teaching neuroimage: cerebrotendinous xanthomatosis.

  Neurology 20080708

• Impact of impurity on kinetic estimates from transport and inhibition studies.

  The Journal of pharmacology and experimental therapeutics 20080701

• Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis.

  American journal of physiology. Renal physiology 20080701

• Metabolic profiling of an Echinostoma caproni infection in the mouse for biomarker discovery.

  PLoS neglected tropical diseases 20080701

• The novel compounds that activate farnesoid X receptor: the diversity of their effects on gene expression.

  Journal of pharmacological sciences 20080701

• Determination of bile acids in human serum by on-line restricted access material-ultra high-performance liquid chromatography-mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080615

• Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

  Journal of medicinal chemistry 20080612

• Bile acid levels are increased in the liver of patients with steatohepatitis.

  European journal of gastroenterology & hepatology 20080601

• Effect of coadsorbent on the photovoltaic performance of zinc pthalocyanine-sensitized solar cells.

  Langmuir : the ACS journal of surfaces and colloids 20080520

• [Effects of farnesoid X receptor ligand on the metabolism of bile acids in rats with estrogen-induced intrahepatic cholestasis of pregnancy].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20080501

• [Analysis of bile acid-related proteins by mass spectrometry].

  Rinsho byori. The Japanese journal of clinical pathology 20080501

• Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma.

  Cancer research 20080415

• Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia.

  Journal of lipid research 20080401

• Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation.

  American journal of physiology. Gastrointestinal and liver physiology 20080401

• Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.

  Journal of medicinal chemistry 20080327

• Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes.

  FEBS letters 20080319

• Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells.

  The Biochemical journal 20080301

• Influence of the semisynthetic bile acid MKC on the ileal permeation of gliclazide in vitro in healthy and diabetic rats treated with probiotics.

  Methods and findings in experimental and clinical pharmacology 20080301

• Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes.

  Cancer letters 20080218

• FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells.

  Cardiovascular research 20080201

• Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells.

  British journal of pharmacology 20080201

• Enhancement of genotype 1 hepatitis C virus replication by bile acids through FXR.

  Journal of hepatology 20080201

• Systematic studies on the paracellular permeation of model permeants and oligonucleotides in the rat small intestine with chenodeoxycholate as enhancer.

  Journal of pharmaceutical sciences 20080101

• The use of High Performance Thin-Layer Chromatography to determine the role of membrane lipid composition in bile salt-induced kidney cell damage.

  Journal of pharmacological and toxicological methods 20080101

• Spectral-resolved gene technology for multiplexed bioluminescence and high-content screening.

  Analytical chemistry 20080101

• Clostridium scindens baiCD and baiH genes encode stereo-specific 7alpha/7beta-hydroxy-3-oxo-delta4-cholenoic acid oxidoreductases.

  Biochimica et biophysica acta 20080101

• Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model.

  Molecular systems biology 20080101

• Role of sulphated polysaccharides from Sargassum Wightii in Cyclosporine A-induced oxidative liver injury in rats.

  BMC pharmacology 20080101

• Effect of colonic bacterial metabolites on Caco-2 cell paracellular permeability in vitro.

  Nutrition and cancer 20080101

• Peroxisome proliferator-activated receptor alpha activates cyclooxygenase-2 gene transcription through bile acid transport in human colorectal cancer cell lines.

  Journal of gastroenterology 20080101

• An amphioxus orthologue of the estrogen receptor that does not bind estradiol: insights into estrogen receptor evolution.

  BMC evolutionary biology 20080101

• Farnesoid X receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101

• Influence of sodium monoketocholate on the hypolipidemic activity of lovastatin in healthy and diabetic rats.

  European journal of drug metabolism and pharmacokinetics 20080101

• Influence of the semisynthetic bile acid (MKC) on the ileal permeation of gliclazide in healthy and diabetic rats.

  Pharmacological reports : PR 20080101

• N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta.

  BMC cell biology 20080101

• Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes.

  Molecular systems biology 20080101

• Bile composition in Alagille Syndrome and PFIC patients having Partial External Biliary Diversion.

  BMC gastroenterology 20080101

• The influence of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanate on gliclazide pharmacokinetics and glucose levels in a rat model of diabetes.

  European journal of drug metabolism and pharmacokinetics 20080101

• Deoxycholic acid induces the overexpression of intestinal mucin, MUC2, via NF-kB signaling pathway in human esophageal adenocarcinoma cells.

  BMC cancer 20080101

• Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry.

  Analytical chemistry insights 20080101

• Organic anion transporting polypeptide 1B3 (OATP1B3) is overexpressed in colorectal tumors and is a predictor of clinical outcome.

  Clinical and experimental gastroenterology 20080101

• Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis.

  Clinical and experimental gastroenterology 20080101

• Regulation of hepatic bile acid transporters Ntcp and Bsep expression.

  Biochemical pharmacology 20071203

• Isolation and chemical synthesis of a major, novel biliary bile acid in the common wombat (Vombatus ursinus): 15alpha-hydroxylithocholic acid.

  Journal of lipid research 20071201

• Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317.

  Journal of lipid research 20071201

• Regulation of human liver delta-aminolevulinic acid synthase by bile acids.

  Hepatology (Baltimore, Md.) 20071201

• Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration.

  Arteriosclerosis, thrombosis, and vascular biology 20071201

• Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids.

  Journal of medicinal chemistry 20071129

• p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis.

  The Journal of biological chemistry 20071123

• Structural and dynamic determinants of ligand binding in the ternary complex of chicken liver bile acid binding protein with two bile salts revealed by NMR.

  Biochemistry 20071106

• Use of selected chemical markers in combination with a multiple regression model to assess the contribution of domesticated animal sources of fecal pollution in the environment.

  Chemosphere 20071101

• COX-2 induction by unconjugated bile acids involves reactive oxygen species-mediated signalling pathways in Barrett's oesophagus and oesophageal adenocarcinoma.

  Gut 20071101

• Novel cytotoxic agents from an unexpected source: bile acids and ovarian tumor apoptosis.

  Gynecologic oncology 20071101

• Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stress.

  Molecular pharmacology 20071101

• Exposure of airway epithelium to bile acids associated with gastroesophageal reflux symptoms: a relation to transforming growth factor-beta1 production and fibroblast proliferation.

  Chest 20071101

• Protective effect of n-3 polyunsaturated fatty acid on primary culture of rat hepatocytes.

  Journal of gastroenterology and hepatology 20071101

• Perinatal bile acid metabolism: bile acid analysis of meconium of preterm and full-term infants.

  Journal of gastroenterology 20071101

• Beneficial effects of hydrocortisone in induced acute pancreatitis of rats.

  Chinese medical journal 20071020

• Protective effects of ursodeoxycholic acid on chenodeoxycholic acid-induced liver injury in hamsters.

  World journal of gastroenterology 20071007

• NMR-based modeling and binding studies of a ternary complex between chicken liver bile acid binding protein and bile acids.

  Proteins 20071001

• Dihydroxy bile acids increase mucosal permeability and bacterial uptake in human colon biopsies.

  Scandinavian journal of gastroenterology 20071001

• A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma.

  Cancer research 20071001

• Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5.

  Journal of medicinal chemistry 20070906

• The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution.

  American journal of physiology. Regulatory, integrative and comparative physiology 20070901

• Role of bile bacteria in gallbladder carcinoma.

  Hepato-gastroenterology 20070901

• Cerebrotendinous xanthomatosis: a treatable cause of metabolic ataxia.

  The Journal of the Association of Physicians of India 20070901

• Lithocholic acid induction of the FGF19 promoter in intestinal cells is mediated by PXR.

  World journal of gastroenterology 20070821

• [Cerebrotendinous xanthomatosis].

  Deutsche medizinische Wochenschrift (1946) 20070729

• Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6).

  The Journal of biological chemistry 20070706

• Adaptive response to increased bile acids: induction of MDR1 gene expression and P-glycoprotein activity in renal epithelial cells.

  Pflugers Archiv : European journal of physiology 20070701

• Human cecal bile acids: concentration and spectrum.

  American journal of physiology. Gastrointestinal and liver physiology 20070701

• Rifampicin-induced CYP3A4 activation in CTX patients cannot replace chenodeoxycholic acid treatment.

  Biochimica et biophysica acta 20070701

• Synthetic organic chemistry based on small ring compounds.

  Chemical & pharmaceutical bulletin 20070701

• Cerebrotendinous xanthomatosis in a Saudi Arabian family-genotyping and long-term follow-up.

  Saudi medical journal 20070701

• Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture.

  American journal of physiology. Gastrointestinal and liver physiology 20070701

• Overexpression of the cholesterol-binding protein MLN64 induces liver damage in the mouse.

  World journal of gastroenterology 20070614

• Bile acids and lipoprotein metabolism: effects of cholestyramine and chenodeoxycholic acid on human hepatic mRNA expression.

  Biochemical and biophysical research communications 20070608

• Ontogenic development-associated changes in the expression of genes involved in rat bile acid homeostasis.

  Journal of lipid research 20070601

• In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue.

  Molecular endocrinology (Baltimore, Md.) 20070601

• Crystal structure of chenodeoxycholic acid, ursodeoxycholic acid and their two 3beta,7alpha- and 3beta,7beta-dihydroxy epimers.

  Steroids 20070601

• Transcriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosis.

  PLoS pathogens 20070601

• Can pigment gallstones be induced by biliary stricture and prevented by medicine in Guinea pigs?

  World journal of gastroenterology 20070521

• On the mechanism of cerebral accumulation of cholestanol in patients with cerebrotendinous xanthomatosis.

  Journal of lipid research 20070501

• Internalization of PrP106-126 by the formyl-peptide-receptor-like-1 in glial cells.

  Journal of neurochemistry 20070501

• Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist.

  Bioorganic & medicinal chemistry 20070401

• Non-invasive analysis of gallbladder bile composition in cynomolgus monkeys using in vivo 1H magnetic resonance spectroscopy.

  Biochimica et biophysica acta 20070401

• A novel chenodeoxycholic derivative HS-1200 enhances radiation-induced apoptosis in MCF-7 cells.

  Oncology reports 20070401

• Why bile acid glucuronidation is a minor pathway for conjugation of endogenous bile acids in man.

  Hepatology (Baltimore, Md.) 20070401

• Coordinated defence and the liver.

  Clinical medicine (London, England) 20070401

• Acquisition of resistance to butyrate induces resistance to luminal components and other types of stress in human colon adenocarcinoma cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20070301

• Glycochenodeoxycholate (GCDC) inhibits cytokine induced iNOS expression in rat hepatocytes.

  The Journal of surgical research 20070301

• Enzymes in the conversion of cholesterol into bile acids.

  Current molecular medicine 20070301

• [Preparation and antitussive, expectorant and antiasthmatic activities of verticinone-bile acids salts].

  Yao xue xue bao = Acta pharmaceutica Sinica 20070301

• Bile acid-mediated thrombospondin-1 induction in hepatocytes leads to transforming growth factor-beta-dependent hepatic stellate cell activation.

  Biochemical and biophysical research communications 20070223

• LC/ESI-tandem mass spectrometric determination of bile acid 3-sulfates in human urine 3beta-Sulfooxy-12alpha-hydroxy-5beta-cholanoic acid is an abundant nonamidated sulfate.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070201

• Analysis of bile acid-induced regulation of FXR target genes in human liver slices.

  Liver international : official journal of the International Association for the Study of the Liver 20070201

• Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole.

  Oncogene 20070111

• Bile acid-induced secretion in polarized monolayers of T84 colonic epithelial cells: Structure-activity relationships.

  American journal of physiology. Gastrointestinal and liver physiology 20070101

• In silico prediction of pregnane X receptor activators by machine learning approaches.

  Molecular pharmacology 20070101

• Comparative study on major bioactive components in natural, artificial and in-vitro cultured Calculus Bovis.

  Chemical & pharmaceutical bulletin 20070101

• Removal of bile acids by two different extracorporeal liver support systems in acute-on-chronic liver failure.

  ASAIO journal (American Society for Artificial Internal Organs : 1992) 20070101

• An improved high throughput protein-protein interaction assay for nuclear hormone receptors.

  Nuclear receptor signaling 20070101

• Bioavailability and hypoglycemic activity of the semisynthetic bile acid salt, sodium 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate, in healthy and diabetic rats.

  European journal of drug metabolism and pharmacokinetics 20070101

• A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model.

  Molecular systems biology 20070101

• Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids.

  PloS one 20070101

• Cerebrotendinous xanthomatosis: case report with evidence of oxidative stress.

  Redox report : communications in free radical research 20070101

• Biomarker discovery in animal health and disease: the application of post-genomic technologies.

  Biomarker insights 20070101

• Dietary chitosan enhances hepatic CYP7A1 activity and reduces plasma and liver cholesterol concentrations in diet-induced hypercholesterolemia in rats.

  Nutrition research and practice 20070101

• Bile acid analysis in biliary tract cancer.

  Yonsei medical journal 20061231

• Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase.

  Journal of lipid research 20061201

• Chenodeoxycholic acid and taurochenodexycholic acid induce anti-apoptotic cIAP-1 expression in human hepatocytes.

  Journal of gastroenterology and hepatology 20061201

• Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man.

  Journal of internal medicine 20061201

• Modulation of the cell cycle and induction of apoptosis in human cancer cells by synthetic bile acids.

  Current cancer drug targets 20061201

• Decreased glucagon responsiveness by bile acids: a role for protein kinase Calpha and glucagon receptor phosphorylation.

  Endocrinology 20061101

• Constitutive androstane receptor (CAR) as a potential sensing biomarker of persistent organic pollutants (POPs) in aquatic mammal: molecular characterization, expression level, and ligand profiling in Baikal seal (Pusa sibirica).

  Toxicological sciences : an official journal of the Society of Toxicology 20061101

• Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver.

  Hepatology (Baltimore, Md.) 20061101

• The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo.

  Molecular pharmacology 20061001

• Presenile cataract: consider cholestanol.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20061001

• The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone.

  Endocrinology 20060901

• Biphasic regulation by bile acids of dermal fibroblast proliferation through regulation of cAMP production and COX-2 expression level.

  American journal of physiology. Cell physiology 20060901

• Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit.

  Journal of lipid research 20060901

• ORF18-disrupted mutant of Comamonas testosteroni TA441 accumulates significant amounts of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid and its derivatives after incubation with steroids.

  The Journal of steroid biochemistry and molecular biology 20060901

• Expression and significance of ICAM-1 and its counter receptors LFA-1 and Mac-1 in experimental acute pancreatitis of rats.

  World journal of gastroenterology 20060821

• Chenodeoxycholic acid stimulates the progression of human esophageal cancer cells: A possible mechanism of angiogenesis in patients with esophageal cancer.

  International journal of cancer 20060815

• Identification of a lead pharmacophore for the development of potent nuclear receptor modulators as anticancer and X syndrome disease therapeutic agents.

  Bioorganic & medicinal chemistry letters 20060815

• Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes.

  World journal of gastroenterology 20060807

• Bile acids induce adhesion molecule expression in endothelial cells through activation of reactive oxygen species, NF-kappaB, and p38.

  American journal of physiology. Heart and circulatory physiology 20060801

• Bile acids stimulate PKCalpha autophosphorylation and activation: role in the attenuation of prostaglandin E1-induced cAMP production in human dermal fibroblasts.

  American journal of physiology. Gastrointestinal and liver physiology 20060801

• Influence of Verapamil and Cyclosporin A on bile acid metabolism and transport in rat liver slices.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20060801

• Characterization of fasted-state human intestinal fluids collected from duodenum and jejunum.

  The Journal of pharmacy and pharmacology 20060801

• Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase.

  Drug metabolism and pharmacokinetics 20060801

• A simple and general strategy for the design of fluorescent cation sensor beads.

  Organic letters 20060720

• Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives.

  Journal of medicinal chemistry 20060713

• Biliary lipid output in the early stage of acute liver failure induced by 90% hepatectomy in the rat.

  The Journal of surgical research 20060701

• Identification of a novel bile acid in swans, tree ducks, and geese: 3alpha,7alpha,15alpha-trihydroxy-5beta-cholan-24-oic acid.

  Journal of lipid research 20060701

• Interaction of native bile acids with human apical sodium-dependent bile acid transporter (hASBT): influence of steroidal hydroxylation pattern and C-24 conjugation.

  Pharmaceutical research 20060701

• Chemical fingerprinting of Shexiang Baoxin Pill and simultaneous determination of its major constituents by HPLC with evaporative light scattering detection and electrospray mass spectrometric detection.

  Chemical & pharmaceutical bulletin 20060701

• Effects of chenodeoxycholic acid and deoxycholic acid on cholesterol absorption and metabolism in humans.

  Translational research : the journal of laboratory and clinical medicine 20060701

• Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands.

  Bioorganic & medicinal chemistry letters 20060615

• Determination of three bile acids in artificial Calculus Bovis and its medicinal preparations by micellar electrokinetic capillary electrophoresis.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060606

• Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.

  American journal of physiology. Gastrointestinal and liver physiology 20060601

• Potential role of trans-inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy.

  Journal of hepatology 20060601

• Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3.

  Journal of lipid research 20060601

• Plasma levels of ursodeoxycholic acid in black bears, Ursus americanus: seasonal changes.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20060601

• Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells.

  Hepatology (Baltimore, Md.) 20060601

• Single-step analysis of individual conjugated bile acids in human bile using 1H NMR spectroscopy.

  Lipids 20060601

• Bile acid promotes the proliferation of squamous cell carcinoma of the esophagus, independent of its inducing COX-2 expression.

  The Journal of surgical research 20060501

• The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha.

  The Journal of pharmacology and experimental therapeutics 20060501

• Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Pharmacophore model for bile acids recognition by the FPR receptor.

  Journal of computer-aided molecular design 20060501

• Bile acid-mediated induction of cyclooxygenase-2 and Mcl-1 in hepatic stellate cells.

  Biochemical and biophysical research communications 20060421

• Exploitation of the alcohol dehydrogenase-acetone NADP-regeneration system for the enzymatic preparative-scale production of 12-ketochenodeoxycholic acid.

  Biotechnology and bioengineering 20060420

• Could steroids mask the diagnosis of cerebrotendinous xanthomatosis?

  Journal of the neurological sciences 20060415

• The region of CQQQKPQRRP of PGC-1alpha interacts with the DNA-binding complex of FXR/RXRalpha.

  Biochemical and biophysical research communications 20060414

• NMR dynamic studies suggest that allosteric activation regulates ligand binding in chicken liver bile acid-binding protein.

  The Journal of biological chemistry 20060407

• 11Beta-hydroxysteroid dehydrogenase type 2 and the regulation of surfactant protein A by dexamethasone metabolites.

  American journal of physiology. Endocrinology and metabolism 20060401

• Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters.

  American journal of physiology. Endocrinology and metabolism 20060401

• Bile acid profiles by capillary electrophoresis in intrahepatic cholestasis of pregnancy.

  Clinical science (London, England : 1979) 20060401

• Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor.

  The Journal of pharmacology and experimental therapeutics 20060401

• Fish oil increases bile acid synthesis in male patients with hypertriglyceridemia.

  The Journal of nutrition 20060401

• Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene.

  Journal of gastroenterology 20060401

• Retrograded tapioca starch prevents ovarian hormone deficiency-induced hypercholesterolemia.

  Journal of nutritional science and vitaminology 20060401

• Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver.

  Archives of biochemistry and biophysics 20060315

• Modulation of cholesterol metabolism by the green tea polyphenol (-)-epigallocatechin gallate in cultured human liver (HepG2) cells.

  Journal of agricultural and food chemistry 20060308

• The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes.

  American journal of physiology. Gastrointestinal and liver physiology 20060301

• Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily.

  The Journal of pharmacology and experimental therapeutics 20060301

• Bile acid transport and metabolism in rat liver slices.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20060301

• Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep.

  American journal of physiology. Gastrointestinal and liver physiology 20060301

• 1,25-dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor.

  The Journal of endocrinology 20060301

• Immunoaffinity extraction of a peptide modified by a small molecule.

  Analytical biochemistry 20060215

• Nuclear receptors, bile-acid detoxification, and cholestasis.

  Lancet (London, England) 20060211

• Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells.

  Circulation research 20060203

• A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids.

  Journal of lipid research 20060201

• Studies of serum and feces bile acids determination by gas chromatography-mass spectrometry.

  Rinsho byori. The Japanese journal of clinical pathology 20060201

• Molecular adsorbent recirculating system (MARS) application in liver failure: clinical and hemodepurative results in 22 patients.

  The International journal of artificial organs 20060201

• FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.

  Journal of lipid research 20060101

• Micellization of conjugated chenodeoxy- and ursodeoxycholates and solubilization of cholesterol into their micelles: comparison with other four conjugated bile salts species.

  Chemistry and physics of lipids 20060101

• Enhancement of DNA topoisomerase I inhibitor-induced apoptosis by ursodeoxycholic acid.

  Molecular cancer therapeutics 20060101

• Bile acid metabolism in extrahepatic biliary atresia: lithocholic acid in stored dried blood collected at neonatal screening.

  Upsala journal of medical sciences 20060101

• Laparoscopic common bile duct exploration in pregnancy with acute gallstone pancreatitis.

  JSLS : Journal of the Society of Laparoendoscopic Surgeons 20060101

• Influence of charge and steric bulk in the C-24 region on the interaction of bile acids with human apical sodium-dependent bile acid transporter.

  Molecular pharmaceutics 20060101

• Chenodeoxycholic acid reduce bacterial translocation in sepsis.

  Medical hypotheses 20060101

• State-of-art methodology of marine natural products chemistry: structure determination with extremely small sample amounts.

  Progress in molecular and subcellular biology 20060101

• Resistance to ursodeoxycholic acid-induced growth arrest can also result in resistance to deoxycholic acid-induced apoptosis and increased tumorgenicity.

  BMC cancer 20060101

• Cerebrotendinous xanthomatosis: need for early diagnosis.

  Indian journal of dermatology, venereology and leprology 20060101

• Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro.

  Molecular cancer 20060101

• Autosomal recessive cerebellar ataxias.

  Orphanet journal of rare diseases 20060101

• Chemical and metabolic transformations of selected bile acids.

  European journal of drug metabolism and pharmacokinetics 20060101

• Pharmacology of bile acids and their derivatives: absorption promoters and therapeutic agents.

  European journal of drug metabolism and pharmacokinetics 20060101

• Increased serum concentrations of secondary bile salts during cholate feeding are due to coprophagy. A study with wild-type and Atp8b1-deficient mice.

  Molecular pharmaceutics 20060101

• [Effect of thromboxane B2 on morphological features of apoptosis in cultured rat hepatocytes exposed to hepatotropic substances].

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20060101

• FTF and LRH-1, two related but different transcription factors in human Caco-2 cells: their different roles in the regulation of bile acid transport.

  Biochimica et biophysica acta 20051230

• Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine.

  The Journal of biological chemistry 20051223

• Effect of a coadsorbent on the performance of dye-sensitized TiO2 solar cells: shielding versus band-edge movement.

  The journal of physical chemistry. B 20051215

• Unusual cerebrotendinous xanthomatosis with fronto-temporal dementia phenotype.

  American journal of medical genetics. Part A 20051201

• Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes.

  Hepatology (Baltimore, Md.) 20051201

• Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus.

  The Journal of biological chemistry 20051111

• Synthetic bile acid derivatives induce apoptosis through a c-Jun N-terminal kinase and NF-kappaB-dependent process in human cervical carcinoma cells.

  Cancer letters 20051108

• Bile acids reduce SR-BI expression in hepatocytes by a pathway involving FXR/RXR, SHP, and LRH-1.

  Biochemical and biophysical research communications 20051104

• Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice.

  Biochemical and biophysical research communications 20051028

• Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis.

  The Journal of pharmacology and experimental therapeutics 20051001

• 1H and 13C NMR characterization and stereochemical assignments of bile acids in aqueous media.

  Lipids 20051001

• Impaired proximal colonic motor response to rectal mechanical and chemical stimulation in obstructed defecation.

  Diseases of the colon and rectum 20050901

• VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium.

  Hepatology (Baltimore, Md.) 20050901

• Downregulation of TACO gene transcription restricts mycobacterial entry/survival within human macrophages.

  FEMS microbiology letters 20050901

• Synthetic chenodeoxycholic acid derivatives inhibit glioblastoma multiform tumor growth in vitro and in vivo.

  International journal of oncology 20050901

• Effect of Larrea tridentata (creosote bush) on cholesterol gallstones and bile secretion in hamsters.

  The Journal of pharmacy and pharmacology 20050901

• Cerebrotendinous xanthomatosis: possible higher prevalence than previously recognized.

  Archives of neurology 20050901

• Bile acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes.

  American journal of physiology. Gastrointestinal and liver physiology 20050801

• A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis.

  The Journal of pharmacology and experimental therapeutics 20050801

• The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes.

  Molecular pharmacology 20050801

• Development of stably transfected monolayer overexpressing the human apical sodium-dependent bile acid transporter (hASBT).

  Pharmaceutical research 20050801

• Characteristics of apoptosis in HCT116 colon cancer cells induced by deoxycholic acid.

  Journal of biochemistry 20050801

• Lithocholic acid decreases expression of UGT2B7 in Caco-2 cells: a potential role for a negative farnesoid X receptor response element.

  Drug metabolism and disposition: the biological fate of chemicals 20050701

• Serum bile acid profile in women during pregnancy and childbed.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20050701

• Pretreatment with ursodeoxycholic acid (UDCA) as a novel pharmacological intervention in hepatobiliary scintigraphy.

  Yonsei medical journal 20050630

• Regulation of ileal bile acid-binding protein expression in Caco-2 cells by ursodeoxycholic acid: role of the farnesoid X receptor.

  Biochemical pharmacology 20050615

• The mechanism underlying the contractile effect of a chemotactic peptide, formyl-Met-Leu-Phe on the guinea-pig Taenia coli.

  British journal of pharmacology 20050601

• The cell envelope structure and properties of Mycobacterium smegmatis mc(2)155: is there a clue for the unique transformability of the strain?

  Microbiology (Reading, England) 20050601

• Induction of human cholesterol 7alpha-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone.

  European journal of pharmacology 20050516

• Transient changes in the expression pattern of key enzymes for bile acid synthesis during rat liver regeneration.

  Biochimica et biophysica acta 20050515

• Feedback regulation of bile acid synthesis in human liver: importance of HNF-4alpha for regulation of CYP7A1.

  Biochemical and biophysical research communications 20050506

• Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis.

  The Journal of pharmacology and experimental therapeutics 20050501

• The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4 alpha and suppressed by bile acids.

  Molecular pharmacology 20050501

• Cerebrotendinous xanthomatosis: a treatable ataxia.

  Neurology 20050426

• Bile acids induce MUC2 overexpression in human colon carcinoma cells.

  Cancer 20050415

• Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene.

  American journal of physiology. Gastrointestinal and liver physiology 20050401

• Chemical synthesis of 24-beta-D-galactopyranosides of bile acids: a new type of bile acid conjugates in human urine.

  Chemistry and physics of lipids 20050401

• Inhibition of hepatocyte growth factor production in human fibroblasts by ursodeoxycholic acid.

  Biological & pharmaceutical bulletin 20050401

• Usefulness of combined measurement of serum bile acids and ferritin as additional prognostic markers to predict failure to reach sustained response to antiviral treatment in chronic hepatitis C.

  Journal of gastroenterology and hepatology 20050401

• Increasing ursodeoxycholic acid in the enterohepatic circulation of pigs through the administration of living bacteria.

  The British journal of nutrition 20050401

• Interfacial properties of most monofluorinated bile acids deviate markedly from the natural congeners: studies with the Langmuir-Pockels surface balance.

  Journal of lipid research 20050301

• Isotopomer spectral analysis of intermediates of cholesterol synthesis in patients with cerebrotendinous xanthomatosis.

  Metabolism: clinical and experimental 20050301

• A new drug carrier, Nalpha-deoxycholyl-L: -lysyl-methylester, for enhancing insulin absorption in the intestine.

  Diabetologia 20050301

• Bile-induced laryngitis: is there a basis in evidence?

  The Annals of otology, rhinology, and laryngology 20050301

• Disrupted coordinate regulation of farnesoid X receptor target genes in a patient with cerebrotendinous xanthomatosis.

  Journal of lipid research 20050201

• Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.

  Archives of biochemistry and biophysics 20050201

• Measurement of hepatic functional mass by means of 13C-methacetin and 13C-phenylalanine breath tests in chronic liver disease: comparison with Child-Pugh score and serum bile acid levels.

  World journal of gastroenterology 20050107

• Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump.

  American journal of physiology. Gastrointestinal and liver physiology 20050101

• Expression of macrophage migration inhibitory factor in esophageal squamous cell carcinoma and effects of bile acids and NSAIDs.

  Carcinogenesis 20050101

• Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative.

  Journal of lipid research 20050101

• Bile acid induced gene expression in LT97 colonic adenoma cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050101

• FXR-activating ligands inhibit rabbit ASBT expression via FXR-SHP-FTF cascade.

  American journal of physiology. Gastrointestinal and liver physiology 20050101

• Esophageal visceral sensitivity to bile salts in patients with functional heartburn and in healthy control subjects.

  Digestive diseases and sciences 20050101

• [Differential approach to detection and treatment of cholelithiasis in outpatient conditions].

  Terapevticheskii arkhiv 20050101

• Inhibition of MRP1-mediated efflux in human erythrocytes by mono-anionic bile salts.

  Anticancer research 20050101

• Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).

  Nuclear receptor 20050101

• Polymorphism in the coding part of the sterol 12alpha-hydroxylase gene does not explain the marked differences in the ratio of cholic acid and chenodeoxycholic acid in human bile.

  Scandinavian journal of clinical and laboratory investigation 20050101

• Inherited cholesterol lipidosis: cerebrotendinous xanthomatosis (van Bogaert Scherer Epstein disease). A clinicopathological study.

  Clinical neuropathology 20050101

• Effects of a 3-mo consumption of short-chain fructo-oligosaccharides on parameters of colorectal carcinogenesis in patients with or without small or large colorectal adenomas.

  Nutrition and cancer 20050101

• Effect of bile acids on butyrate-sensitive and -resistant human colon adenocarcinoma cells.

  Nutrition and cancer 20050101

• Determination of underivatised sterols and bile acid trimethyl silyl ether methyl esters by gas chromatography-mass spectrometry-single ion monitoring in faeces.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225

• Effects of bile acids on proliferation and production of proteinase activity of Uronema marinum (Ciliophora: Scuticociliatida).

  Diseases of aquatic organisms 20041213

• Megalin and cubilin expression in gallbladder epithelium and regulation by bile acids.

  Journal of lipid research 20041201

• Farnesoid X receptor represses hepatic lipase gene expression.

  Journal of lipid research 20041101

• The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis.

  Gastroenterology 20041101

• Multidrug resistance3 is in situ detected in the liver of patients with primary biliary cirrhosis, and induced in human hepatoma cells by bezafibrate.

  Hepatology research : the official journal of the Japan Society of Hepatology 20041101

• Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4.

  The Journal of biological chemistry 20041029

• Effects of meal frequency and high-fibre rye-bread diet on glucose and lipid metabolism and ileal excretion of energy and sterols in ileostomy subjects.

  European journal of clinical nutrition 20041001

• Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16.

  PLoS biology 20041001

• Normalisation of serum cholestanol concentration in a patient with cerebrotendinous xanthomatosis by combined treatment with chenodeoxycholic acid, simvastatin and LDL apheresis.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20041001

• The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner.

  The Biochemical journal 20040915

• Bioconversion of 3beta-hydroxy-5-cholenoic acid into chenodeoxycholic acid by rat brain enzyme systems.

  Journal of lipid research 20040901

• The farnesoid X receptor: a novel drug target?

  Expert opinion on investigational drugs 20040901

• Ursodeoxycholate/Sulindac combination treatment effectively prevents intestinal adenomas in a mouse model of polyposis.

  Gastroenterology 20040901

• DNA hypomethylation induced by non-genotoxic carcinogens in mouse and rat colon.

  Cancer letters 20040830

• Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid.

  Journal of medicinal chemistry 20040826

• Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor.

  Journal of lipid research 20040801

• Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets.

  DNA and cell biology 20040801

• Synthetic bile acid derivatives inhibit cell proliferation and induce apoptosis in HT-29 human colon cancer cells.

  International journal of oncology 20040701

• Cyclosporine A-induced reduction of bile salt synthesis associated with increased plasma lipids in children after liver transplantation.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20040701

• Bile acid-induced negative feedback regulation of the human ileal bile acid transporter.

  Hepatology (Baltimore, Md.) 20040701

• [Menthol in the adjuvant treatment of gallbladder stones fragmented by ESWL as an option for reducing doses of urso- and chenodeoxycholic acid].

  Medizinische Klinik (Munich, Germany : 1983) 20040615

• Epimerization of chenodeoxycholic acid to ursodeoxycholic acid by Clostridium baratii isolated from human feces.

  FEMS microbiology letters 20040601

• Effect of chenodeoxycholic acid on 11beta-hydroxysteroid dehydrogenase in various target tissues.

  Metabolism: clinical and experimental 20040601

• Short-step synthesis of chenodiol from stigmasterol.

  Bioscience, biotechnology, and biochemistry 20040601

• [Cerebrotendinous xanthomatosis--a treatable metabolic disorder].

  Der Nervenarzt 20040601

• The bile acid nuclear receptor FXR and the bile acid binding protein IBABP are differently expressed in colon cancer.

  Digestive diseases and sciences 20040601

• Production of prostaglandinE2 via bile acid is enhanced by trypsin and acid in normal human esophageal epithelial cells.

  Life sciences 20040521

• The farnesoid X receptor induces very low density lipoprotein receptor gene expression.

  FEBS letters 20040521

• Ion-selective electrodes based on molecular tweezer-type neutral carriers.

  Talanta 20040510

• Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis.

  Toxicological sciences : an official journal of the Society of Toxicology 20040501

• Hydrophilic 7 beta-hydroxy bile acids, lovastatin, and cholestyramine are ineffective in the treatment of cerebrotendinous xanthomatosis.

  Metabolism: clinical and experimental 20040501

• [Studies on mechanism of antiasthmatic and anti-inflammatory actions of CDCA].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040401

• The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion.

  The Journal of biological chemistry 20040305

• Bile acids induce cyclooxygenase-2 expression in human pancreatic cancer cell lines.

  Carcinogenesis 20040301

• [Studies on antitussive, antiasthmatic and expectorant action of chenodeoxycholine acid].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040301

• Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of the human angiotensinogen gene.

  The Journal of biological chemistry 20040227

• Serum bile acids and risk factors for colorectal cancer.

  British journal of cancer 20040209

• Presence of protein-bound unconjugated bile acids in the cytoplasmic fraction of rat brain.

  Journal of lipid research 20040201

• Cerebrotendinous xanthomatosis: clinical course, genotypes and metabolic backgrounds.

  Clinical and investigative medicine. Medecine clinique et experimentale 20040201

• Increased acyclovir oral bioavailability via a bile acid conjugate.

  Molecular pharmaceutics 20040112

• Facile synthesis, aggregation behavior, and cholesterol solubilization ability of avicholic acid.

  Organic letters 20040108

• Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation.

  Journal of lipid research 20040101

• Cross-resistance to antibiotics of Escherichia coli adapted to benzalkonium chloride or exposed to stress-inducers.

  Journal of applied microbiology 20040101

• Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs.

  Lipids in health and disease 20040101

• 3Alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate as blood-brain barrier permeator.

  Polish journal of pharmacology 20040101

• Comparison among fecal secondary bile acid levels, fecal microbiota and Clostridium scindens cell numbers in Japanese.

  Microbiology and immunology 20040101

• Enhanced susceptibility of LDL to oxidative modification in a CTX patient:- role of chenodeoxycholic acid in xanthoma formation.

  Journal of atherosclerosis and thrombosis 20040101

• T0901317 is a dual LXR/FXR agonist.

  Molecular genetics and metabolism 20040101

• Farnesoid X receptor activates transcription of the phospholipid pump MDR3.

  The Journal of biological chemistry 20031219

• Combined treatment with LDL-apheresis, chenodeoxycholic acid and HMG-CoA reductase inhibitor for cerebrotendinous xanthomatosis.

  Journal of the neurological sciences 20031215

• Fluorescence resonance energy transfer in a novel cyclodextrin-peptide conjugate for detecting steroid molecules.

  Bioorganic & medicinal chemistry letters 20031215

• Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.

  The Journal of clinical investigation 20031201

• In vitro farnesoid X receptor ligand sensor assay using surface plasmon resonance and based on ligand-induced coactivator association.

  The Journal of steroid biochemistry and molecular biology 20031201

• Impairment of blood rheology by cholestatic jaundice in human beings.

  The Journal of laboratory and clinical medicine 20031201

• Cloning and characterization of the NAD-dependent 7alpha-Hydroxysteroid dehydrogenase from Bacteroides fragilis.

  Current microbiology 20031201

• Orphan nuclear receptor Nur77 translocates to mitochondria in the early phase of apoptosis induced by synthetic chenodeoxycholic acid derivatives in human stomach cancer cell line SNU-1.

  Annals of the New York Academy of Sciences 20031201

• Micelle formation of sodium chenodeoxycholate and solubilization into the micelles: comparison with other unconjugated bile salts.

  Biochimica et biophysica acta 20031115

• Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake.

  American journal of physiology. Gastrointestinal and liver physiology 20031101

• Bile acid composition in snake bile juice and toxicity of snake bile acids to rats.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20031101

• Metabolic changes in Clostridium absonum ATCC 27555 accompanying induction of epimerization of a primary bile acid.

  Current microbiology 20031101

• Ligand-binding domain of farnesoid X receptor (FXR) had the highest sensitivity and activity among FXR variants in a fluorescence-based assay.

  Lipids 20031101

• Gallstones - approach to medical management.

  MedGenMed : Medscape general medicine 20031015

• Steroid ring hydroxylation patterns govern cooperativity in human bile acid binding protein.

  Biochemistry 20031014

• Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy.

  Gut 20031001

• Inhibition of the rat hepatic microsomal flurbiprofen acyl glucuronidation by bile acids.

  Journal of pharmaceutical sciences 20031001

• Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor.

  Hepatology (Baltimore, Md.) 20031001

• Biliary diversion for progressive familial intrahepatic cholestasis: improved liver morphology and bile acid profile.

  Gastroenterology 20031001

• Apoptosis and modulation of cell cycle control by synthetic derivatives of ursodeoxycholic acid and chenodeoxycholic acid in human prostate cancer cells.

  Cancer letters 20030925

• The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.

  Molecular endocrinology (Baltimore, Md.) 20030901

• Cerebrotendinous xanthomatosis: clinical manifestations, diagnostic criteria, pathogenesis, and therapy.

  Journal of child neurology 20030901

• Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha).

  Gene 20030814

• Human kininogen gene is transactivated by the farnesoid X receptor.

  The Journal of biological chemistry 20030801

• Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis.

  Genes & development 20030701

• Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR).

  Bioorganic & medicinal chemistry letters 20030602

• Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids.

  The Biochemical journal 20030601

• Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats.

  Toxicological sciences : an official journal of the Society of Toxicology 20030601

• Hydrophilic but not hydrophobic bile acids prevent gallbladder muscle dysfunction in acute cholecystitis.

  Hepatology (Baltimore, Md.) 20030601

• Bile acid induces cyclo-oxygenase-2 expression in cultured human pharyngeal cells: a possible mechanism of carcinogenesis in the upper aerodigestive tract by laryngopharyngeal reflux.

  The Laryngoscope 20030601

• FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity.

  Gastroenterology 20030601

• Influence of ethinyloestradiol propanolsulphonate on serum bile acids in healthy volunteers.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20030601

• Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter.

  The Journal of biological chemistry 20030530

• Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor.

  The Journal of biological chemistry 20030530

• Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat.

  Metabolism: clinical and experimental 20030501

• Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.

  Biochemical and biophysical research communications 20030425

• Regression of diaphyseal multiloculated bone cyst in familial steroid dehydrogenase deficiency.

  Journal of pediatric gastroenterology and nutrition 20030401

• A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.

  Molecular cell 20030401

• Gum arabic (GA) modifies paracellular water and electrolyte transport in the small intestine.

  Digestive diseases and sciences 20030401

• Retinoid X receptor (RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to absence of coactivator recruitment and decreased DNA binding.

  The Journal of biological chemistry 20030321

• Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump.

  The Journal of biological chemistry 20030321

• Inhibitory effects of ursodeoxycholic acid on the induction of nitric oxide synthase in vascular smooth muscle cells.

  European journal of pharmacology 20030319

• A G protein-coupled receptor responsive to bile acids.

  The Journal of biological chemistry 20030314

• Differentiated thermal crystallization from amorphous chenodeoxycholic acid between the ground specimens derived from the polymorphs.

  International journal of pharmaceutics 20030306

• Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression.

  Hepatology (Baltimore, Md.) 20030301

• Synthetic chenodeoxycholic acid derivative HS-1200-induced apoptosis of p815 mastocytoma cells is augmented by co-treatment with lactacystin.

  Anti-cancer drugs 20030301

• Chenodeoxycholate induction of mitochondrial permeability transition pore is associated with increased membrane fluidity and cytochrome c release: protective role of carvedilol.

  Mitochondrion 20030301

• Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance.

  Proceedings of the National Academy of Sciences of the United States of America 20030204

• Upregulation of the oncogene c-myc in Barrett's adenocarcinoma: induction of c-myc by acidified bile acid in vitro.

  Gut 20030201

• Glucosidation of hyodeoxycholic acid by UDP-glucuronosyltransferase 2B7.

  Biochemical pharmacology 20030201

• Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.

  Molecular endocrinology (Baltimore, Md.) 20030201

• Increase of bile acid production by tacrolimus in the rat liver.

  Transplantation proceedings 20030201

• Mitochondrially mediated synergistic cell killing by bile acids.

  Biochimica et biophysica acta 20030120

• Influence of breast feeding, and adapted and hydrolyzed formulas on biliary bile acids in newborn guinea pigs.

  Biology of the neonate 20030101

• Role of MR imaging in the diagnosis of cerebrotendinous xanthogranulomatosis, case report and review of literature.

  La Radiologia medica 20030101

• Taurochenodeoxycholic acid induced biphasic hepatotoxicity in isolated perfused rat liver: roles of Ca2+ and calpain.

  Hepato-gastroenterology 20030101

• The cytotoxicity of hydrophobic bile acids is ameliorated by more hydrophilic bile acids in intestinal cell lines IEC-6 and Caco-2.

  Oncology reports 20030101

• Cholestanol metabolism, molecular pathology, and nutritional implications.

  Journal of medicinal food 20030101

• Reproducibility of the serum lipid response to coffee oil in healthy volunteers.

  Nutrition journal 20030101

• [Cerebrotendinous xanthomatosis, a treatable metabolic disorder].

  Der Nervenarzt 20021201

• [Cerebrotendinous xanthomatosis without tendinous xanthomas: presentation of two cases].

  Neurologia (Barcelona, Spain) 20021201

• Selective inhibition of CYP27A1 and of chenodeoxycholic acid synthesis in cholestatic hamster liver.

  Biochimica et biophysica acta 20021120

• Identification of membrane-type receptor for bile acids (M-BAR).

  Biochemical and biophysical research communications 20021115

• Bile acids enhance low density lipoprotein receptor gene expression via a MAPK cascade-mediated stabilization of mRNA.

  The Journal of biological chemistry 20021004

• Bile acids stimulate invasion and haptotaxis in human colorectal cancer cells through activation of multiple oncogenic signaling pathways.

  Oncogene 20021003

• The impact of the absence of glycopeptidolipids on the ultrastructure, cell surface and cell wall properties, and phagocytosis of Mycobacterium smegmatis.

  Microbiology (Reading, England) 20021001

• Potential bile acid metabolites. 25. Synthesis and chemical properties of stereoisomeric 3alpha,7alpha,16- and 3alpha,7alpha,15-trihydroxy-5beta-cholan-24-oic acids.

  Chemical & pharmaceutical bulletin 20021001

• Mutations in the sterol 27-hydroxylase gene (CYP27A) cause hepatitis of infancy as well as cerebrotendinous xanthomatosis.

  Journal of inherited metabolic disease 20021001

• Effect of chenodeoxycholic acid on the toxicity of 5alpha-cyprinol sulfate in rats.

  Toxicology 20020930

• Synthesis of [3,4-(13)c(2)]-enriched bile salts as NMR probes of protein-ligand interactions.

  The Journal of organic chemistry 20020920

• Regulation of hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and cholesterol 7alpha-hydroxylase mRNAs in human liver.

  The Journal of clinical endocrinology and metabolism 20020901

• A monoclonal antibody-based enzyme-linked immunosorbent assay of glycolithocholic acid sulfate in human urine for liver function test.

  Steroids 20020901

• Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity.

  The Journal of biological chemistry 20020830

• 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

  Journal of medicinal chemistry 20020815

• Changes in bile acid composition and effect on cytolytic activity of fecal water by ursodeoxycholic acid administration: a placebo-controlled cross-over intervention trial in healthy volunteers.

  Scandinavian journal of gastroenterology 20020801

• Differences in the regulation of the classical and the alternative pathway for bile acid synthesis in human liver. No coordinate regulation of CYP7A1 and CYP27A1.

  The Journal of biological chemistry 20020726

• The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate.

  The Journal of biological chemistry 20020719

• Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor.

  The Journal of biological chemistry 20020719

• Fibrates suppress chenodeoxycholic acid-induced RANTES expression through inhibition of NF-kappaB activation.

  European journal of pharmacology 20020712

• Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling.

  The Journal of biological chemistry 20020705

• On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha.

  Biochimica et biophysica acta 20020613

• A prospective study of serum bile acid concentrations and colorectal cancer risk in post-menopausal women on the island of Guernsey.

  British journal of cancer 20020605

• Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor.

  Gastroenterology 20020601

• Postprandial changes in serum unconjugated bile acid concentrations in healthy beagles.

  American journal of veterinary research 20020601

• Effect of colestimide on absorption of unconjugated bile acids in the rat jejunum.

  Journal of gastroenterology and hepatology 20020601

• A natural product that lowers cholesterol as an antagonist ligand for FXR.

  Science (New York, N.Y.) 20020531

• Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters.

  Gene 20020515

• A novel primary bile acid in the Shoebill stork and herons and its phylogenetic significance.

  Journal of lipid research 20020501

• Relationship between asymptomatic hypercholanaemia of pregnancy and progesterone metabolism.

  Clinical science (London, England : 1979) 20020501

• Immunosuppressive effect of chenodeoxycholic acid on natural killer cell activity in patients with biliary atresia and hepatitis C virus-related liver cirrhosis.

  Digestive diseases and sciences 20020501

• Disruption of mitochondrial calcium homeostasis after chronic alpha-naphthylisothiocyanate administration: relevance for cholestasis.

  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20020501

• Characterization of cloned mouse Na+/taurocholate cotransporting polypeptide by transient expression in COS-7 cells.

  Bioscience, biotechnology, and biochemistry 20020501

• Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes.

  Hepatology (Baltimore, Md.) 20020401

• Cerebrotendinous xanthomatosis: a rare disease with diverse manifestations.

  Archives of neurology 20020401

• [Treatment of cholestatic liver diseases].

  Medizinische Klinik (Munich, Germany : 1983) 20020315

• The proximal colonic motor response to rectal mechanical and chemical stimulation.

  American journal of physiology. Gastrointestinal and liver physiology 20020301

• Characterization of rat liver bile acid acyl glucuronosyltransferase.

  Steroids 20020301

• Unconjugated bile acids modulate adult and neonatal neutrophil chemotaxis induced in vitro by N-formyl-met-leu-phe-peptide.

  Pediatric research 20020301

• Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump.

  Hepatology (Baltimore, Md.) 20020301

• The UDCA dosage deficit: a fate shared with CDCA.

  European journal of gastroenterology & hepatology 20020301

• Two novel mutations in the sterol 27-hydroxylase gene causing cerebrotendinous xanthomatosis.

  Clinical genetics 20020301

• Interactions of combined bile acids on hepatocyte viability: cytoprotection or synergism.

  Toxicology letters 20020207

• Use of ursodeoxycholic acid in patients with liver disease.

  Current gastroenterology reports 20020201

• MALDI-TOF-MS analysis of droplets prepared in an electrodynamic balance: 'wall-less' sample preparation.

  Analytical chemistry 20020201

• Guest-responsive fluorescence variations of gamma-cyclodextrins labeled with hetero-functionalized pyrene and tosyl moieties.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20020201

• Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis?

  The Journal of laboratory and clinical medicine 20020201

• Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.

  The Journal of biological chemistry 20020125

• Induction of cyclooxygenase-2 by tumor promoters in transformed and cytochrome P450 2E1-expressing hepatocytes.

  Carcinogenesis 20020101

• Bile salts modulate chronic ethanol-induced hepatotoxicity.

  Alcohol and alcoholism (Oxford, Oxfordshire) 20020101

• Demonstration of a direct stimulatory effect of bile salts on rat colonic epithelial cell proliferation.

  Scandinavian journal of gastroenterology 20020101

• Effects of bile acids on base hydroxylation in a model of human colonic mucosal DNA.

  Cancer detection and prevention 20020101

• Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytes.

  Journal of pharmacological and toxicological methods 20020101

• Enhanced expression of the human multidrug resistance protein 3 by bile salt in human enterocytes. A transcriptional control of a plausible bile acid transporter.

  The Journal of biological chemistry 20011214

• Antagonism of the actions of peroxisome proliferator-activated receptor-alpha by bile acids.

  The Journal of biological chemistry 20011214

• Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: evidence for involvement of bile acids.

  Gastroenterology 20011201

• Effect of bile acids on absorption of nitrendipine in healthy subjects.

  British journal of clinical pharmacology 20011201

• Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20011201

• Anti-inflammatory effects of 5-aminosalicylic acid conjugates with chenodeoxycholic acid and ursodeoxycholic acid on carrageenan-induced colitis in guinea-pigs.

  The Journal of pharmacy and pharmacology 20011201

• Predominance of human versus rat phenotype in the metabolic pathways for bile acid synthesis by hybrid WIF-B9 cells.

  Biochimica et biophysica acta 20011130

• Bile acids regulate RANTES gene expression through its cognate NF-kappaB binding sites.

  Biochemical and biophysical research communications 20011116

• Cerebrotendinous xanthomatosis.

  Neurology 20011113

• Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression.

  The Journal of biological chemistry 20011109

• Reduced activity of 11 beta-hydroxysteroid dehydrogenase in patients with cholestasis.

  The Journal of clinical investigation 20011101

• Green tea upregulates the low-density lipoprotein receptor through the sterol-regulated element binding Protein in HepG2 liver cells.

  Journal of agricultural and food chemistry 20011101

• Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

  The Journal of biological chemistry 20011019

• Functional analysis of the transcriptional activity of the mouse phospholipid transfer protein gene.

  Biochemical and biophysical research communications 20011005

• Effects of bile acids on the humoral immune response: a mechanistic approach.

  Life sciences 20011005

• Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids.

  Molecular endocrinology (Baltimore, Md.) 20011001

• Acute effects of dietary fat composition on postprandial plasma bile acid and cholecystokinin concentrations in healthy premenopausal women.

  The British journal of nutrition 20011001

• 3beta-hydroxy-delta5 -C27-steroid dehydrogenase deficiency: diagnosis and treatment.

  Journal of paediatrics and child health 20011001

• Cerebrotendinous xanthomatosis: 11-year treatment with chenodeoxycholic acid in five patients. An electrophysiological study.

  Journal of the neurological sciences 20010915

• Nuclear receptor-mediated repression of human cholesterol 7alpha-hydroxylase gene transcription by bile acids.

  Journal of lipid research 20010901

• Biliary excretion of tauroursodeoxycholate-3-sulfate in the rat.

  Steroids 20010901

• [Cerebrotendinous xanthomatosis].

  Nederlands tijdschrift voor geneeskunde 20010901

• External biliary drainage plus bile acid feeding is not equal to internal drainage in preserving the cellular immunity following prolonged obstructive jaundice.

  Digestive diseases and sciences 20010901

• Effect of bile acids on formation of azoxymethane-induced aberrant crypt foci in colostomized F344 rat colon.

  Cancer letters 20010828

• The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors.

  The Journal of biological chemistry 20010817

• Cerebrotendinous xanthomatosis.

  Journal of the American Academy of Dermatology 20010801

• Cerebrotendinous xanthomatosis presenting as 'chologenic diarrhoea'.

  Acta paediatrica (Oslo, Norway : 1992) 20010701

• Protective effect of carvedilol on chenodeoxycholate induction of the permeability transition pore.

  Biochemical pharmacology 20010601

• Bile acid hydrophobicity is correlated with induction of apoptosis and/or growth arrest in HCT116 cells.

  The Biochemical journal 20010601

• Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo.

  Gastroenterology 20010601

• Effect of bile salts on colonic mucus secretion in isolated vascularly perfused rat colon.

  Digestive diseases and sciences 20010601

• Apoptotic activity of novel bile acid derivatives in human leukemic T cells through the activation of caspases.

  International journal of oncology 20010501

• Effects of treatment with deoxycholic acid and chenodeoxycholic acid on the hepatic synthesis of cholesterol and bile acids in healthy subjects.

  Hepatology (Baltimore, Md.) 20010501

• Synthetic bile acid derivatives induce nonapoptotic death of human retinal pigment epithelial cells.

  Current eye research 20010501

• Enhancement of endothelial nitric oxide production by chenodeoxycholic acids in patients with hepatobiliary diseases.

  Japanese heart journal 20010501

• Effects of bile salts and aliphatic ionic surfactants on human lymphocyte proliferation.

  European journal of clinical investigation 20010401

• Successful combination therapy--flunarizine, pentoxifylline, and cholestyramine--for spur cell anemia.

  International journal of hematology 20010401

• LUV's lipid composition modulates diffusion of bile acids.

  Chemistry and physics of lipids 20010401

• Cloning and expression of a pig liver taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily.

  The Journal of biological chemistry 20010330

• Chenodeoxycholic treatment of cerebrotendinous xanthomatosis.

  Neurology 20010313

• Ursodeoxycholic acid administration in patients with cholestasis of pregnancy: effects on primary bile acids in babies and mothers.

  Hepatology (Baltimore, Md.) 20010301

• High-performance liquid chromatographic determination of ursodeoxycholic acid after solid phase extraction of blood serum and detection-oriented derivatization.

  Journal of pharmaceutical and biomedical analysis 20010301

• The nuclear receptors FXR and LXRalpha: potential targets for the development of drugs affecting lipid metabolism and neoplastic diseases.

  Current pharmaceutical design 20010301

• Hypocholesterolemic effect of bile acid sulfonate analogs in hamsters.

  Biological & pharmaceutical bulletin 20010301

• Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid.

  Journal of hepatology 20010301

• [3 beta-Hydroxysteroid-delta 5-oxidoreductase/isomerase deficiency].

  Nihon rinsho. Japanese journal of clinical medicine 20010301

• [3-oxo-delta 4-steroid 5 beta-reductase deficiency].

  Nihon rinsho. Japanese journal of clinical medicine 20010301

• [Cerebrotendinous xanthomatosis].

  Nihon rinsho. Japanese journal of clinical medicine 20010301

• [Other antihyperlipidemic drugs with novel mechanism].

  Nihon rinsho. Japanese journal of clinical medicine 20010301

• Novel bile acid derivatives induce apoptosis via a p53-independent pathway in human breast carcinoma cells.

  Cancer letters 20010210

• Colonic luminal contents induce cyclooxygenase 2 transcription in human colon carcinoma cells.

  Gastroenterology 20010201

• Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27(-/-) mice and CTX.

  Journal of lipid research 20010201

• Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria.

  Bioscience reports 20010201

• Magnetic resonance imaging and spectroscopic changes in brains of patients with cerebrotendinous xanthomatosis.

  Brain : a journal of neurology 20010101

• Ursodeoxycholic acid alone or with chenodeoxycholic acid for dissolution of cholesterol gallstones: a randomized multicentre trial. The British-Italian Gallstone Study group.

  Alimentary pharmacology & therapeutics 20010101

• Determination of bile acids in biological fluids by liquid chromatography-electrospray tandem mass spectrometry.

  Journal of lipid research 20010101

• [Advances in the diagnosis and treatment of cholelithiasis].

  Terapevticheskii arkhiv 20010101

• Cerebrotendinous xanthomatosis in three siblings from a Chinese family.

  Singapore medical journal 20010101

• Enzyme immunoassay for conjugated 7alpha-hydroxy-3-oxo-4-cholenoic acid in human urine.

  Journal of immunoassay & immunochemistry 20010101

• Suppression of renal disease and mortality in the female NZB x NZW F1 mouse model of systemic lupus erythematosus (SLE) by chenodeoxycholic acid.

  Lupus 20010101

• Differential modulation of cellular death and survival pathways by conjugated bile acids.

  BMC biochemistry 20010101

• Extracorporeal shock wave lithotripsy of gallstones with oral dissolution. Results in course of ten years in Czech Republic in correlation to indication criteria.

  Sbornik lekarsky 20010101

• Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20001201

• Identification of a chemical tool for the orphan nuclear receptor FXR.

  Journal of medicinal chemistry 20000810

• In the search for specific inhibitors of human 11beta-hydroxysteroid-dehydrogenases (11beta-HSDs): chenodeoxycholic acid selectively inhibits 11beta-HSD-I.

  European journal of endocrinology 20000201

• Identification of a nuclear receptor for bile acids.

  Science (New York, N.Y.) 19990521

• Bile acids: natural ligands for an orphan nuclear receptor.

  Science (New York, N.Y.) 19990521

• Endogenous bile acids are ligands for the nuclear receptor FXR/BAR.

  Molecular cell 19990501

• Differential effects of 17alpha-ethinylestradiol on the neutral and acidic pathways of bile salt synthesis in the rat.

  Journal of lipid research 19990101

• Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter.

  The American journal of physiology 19980101

• Triterpenes as potential dimerization inhibitors of HIV-1 protease.

  Biochemical and biophysical research communications 19961014

• Bile acids produce a generalized reduction of the catalytic activity of cytochromes P450 and other hepatic microsomal enzymes in vitro: relevance to drug metabolism in experimental cholestasis.

  Journal of gastroenterology and hepatology 19960901

• Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids.

  Carcinogenesis 19960301

• Cyclosporin A-mediated cholestasis in patients with chronic hepatitis after heart transplantation.

  European journal of gastroenterology & hepatology 19960301

• Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.

  The Biochemical journal 19960115

• Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytes.

  The Biochemical journal 19950115

• Ursodeoxycholic acid in the Ursidae: biliary bile acids of bears, pandas, and related carnivores.

  Journal of lipid research 19931101

• cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family.

  The Journal of biological chemistry 19930515

• Oral and contact dissolution of gallstones.

  American journal of surgery 19930401

• Promotion of hepatocellular foci in female rats by chenodeoxycholic acid.

  Carcinogenesis 19910101

• Benign recurrent intrahepatic cholestasis: altered bile acid metabolism.

  Gastroenterology 19890801

• Selective activity of several cholic acid derivatives against human immunodeficiency virus replication in vitro.

  Journal of acquired immune deficiency syndromes 19890101

• [Promoting effect of bile acids on gastric carcinogenesis induced by MNNG in rats].

  Nihon Geka Gakkai zasshi 19890101

• [Effect of bile and bile acids on monoamine oxidase and acetylcholinesterase activity in the jejunum of rabbits, guinea pigs and swine].

  Polskie archiwum weterynaryjne 19870101

• Evidence for an ordered reaction mechanism for bile salt: 3'phosphoadenosine-5'-phosphosulfate: sulfotransferase from rhesus monkey liver that catalyzes the sulfation of the hepatotoxin glycolithocholate.

  Journal of lipid research 19861101

• Inhibition of hepatic and extrahepatic glutathione S-transferases by primary and secondary bile acids.

  The Biochemical journal 19860115

• Comparative efficacy and side effects of ursodeoxycholic and chenodeoxycholic acids in dissolving gallstones. A double-blind controlled study.

  Gastroenterology 19831201

• Early morphologic and enzymatic changes in livers of rats treated with chenodeoxycholic and ursodeoxycholic acids.

  Hepatology (Baltimore, Md.) 19830101

• Serum bile acid levels in intrahepatic cholestasis of pregnancy during treatment with phenobarbital or cholestyramine.

  European journal of obstetrics, gynecology, and reproductive biology 19821201

• Carcinoma of the gall-bladder in a patient on long-term chenodeoxycholic acid therapy.

  Clinical oncology 19810901

• Lack of response to chenodeoxycholic acid in obese and non-obese patients. Role of cholesterol synthesis and possible response to ursodeoxycholic acid.

  Gut 19801201

• [Effect of cholestyramine and chenodesoxycholic acid on liver cirrhosis. An experimental study in rats].

  Zeitschrift fur experimentelle Chirurgie 19800401

• Hepatic toxicity in the rhesus monkey treated with chenodeoxycholic acid for 6 months: biochemical and ultrastructural studies.

  Gastroenterology 19760101

• Effects of clofibrate in primary biliary cirrhosis hypercholesterolemia and gallstones.

  Gastroenterology 19751001

• Measurement of bile acid synthesis by 14CO2: the metabolism of propionyl CoA.

  Steroids 19751001

• Toxicity of chenodeoxycholic acid in the rhesus monkey.

  Gastroenterology 19750801

• Toxicity of chenodeoxycholic acid in the nonhuman primate.

  Surgery 19750601

• Medical treatment of gallstones.

  Southern medical journal 19750101

• [Effects of diet on bile secretion].

  Acta medica Austriaca 19750101

• Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo.

  Molecular endocrinology (Baltimore, Md.)

• Bile acids down-regulate caveolin-1 in esophageal epithelial cells through sterol responsive element-binding protein.

  Molecular endocrinology (Baltimore, Md.)