478-01-3 | Nobiletin

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$11.00	$8.00
5mg	≥98%	in stock	$47.00	$33.00
25mg	99%(HPLC)powder	in stock	$50.00	$35.00
100mg	98%	in stock	$58.00	$41.00
250mg	98%	in stock	$85.00	$60.00
5g	98%	in stock	$647.00	$453.00

Description

• Catalog Number: AB77686
• Chemical Name: Nobiletin
• CAS Number: 478-01-3
• Molecular Formula: C21H22O8
• Molecular Weight: 402.3946
• MDL Number: MFCD03273560
• SMILES: COc1cc(ccc1OC)c1cc(=O)c2c(o1)c(OC)c(c(c2OC)OC)OC

Computed Properties

• Complexity: 593
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• XLogP3: 3

Literature

• Upregulation of N-methyl-D-aspartate receptor subunits and c-Fos expressing genes in PC12D cells by nobiletin.

  Biological & pharmaceutical bulletin 20140101

• Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines.

  Biochemical and biophysical research communications 20130215

• Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress.

  Food chemistry 20121215

• Development and validation of a highly sensitive LC-MS/MS-ESI method for the determination of nobiletin in rat plasma: application to a pharmacokinetic study.

  Biomedical chromatography : BMC 20121201

• Evaluation of Citrus aurantifolia peel and leaves extracts for their chemical composition, antioxidant and anti-cholinesterase activities.

  Journal of the science of food and agriculture 20121201

• Dietary polyphenols and mechanisms of osteoarthritis.

  The Journal of nutritional biochemistry 20121101

• Antimetastatic effect of nobiletin through the down-regulation of CXC chemokine receptor type 4 and matrix metallopeptidase-9.

  Pharmaceutical biology 20121001

• Inhibitory effects of Citrus flavonoids on starch digestion and antihyperglycemic effects in HepG2 cells.

  Journal of agricultural and food chemistry 20120926

• Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901

• The composition of volatile aroma components, flavanones, and polymethoxylated flavones in Shiikuwasha (Citrus depressa Hayata) peels of different cultivation lines.

  Journal of agricultural and food chemistry 20120815

• In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent.

  Molecular nutrition & food research 20120601

• The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease.

  European journal of pharmacology 20120505

• Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture induction.

  Biochimica et biophysica acta 20120401

• Synergistic anti-inflammatory effects of nobiletin and sulforaphane in lipopolysaccharide-stimulated RAW 264.7 cells.

  Journal of agricultural and food chemistry 20120307

• Antiproliferative effects of Dangyuja (Citrus grandis Osbeck) leaves through suppression of constitutive signal transducer and activator of transcription 3 activation in human prostate carcinoma DU145 cells.

  Journal of medicinal food 20120201

• Phenolic constituents from the heartwood of Artocapus altilis and their tyrosinase inhibitory activity.

  Natural product communications 20120201

• The oxidative state of chylomicron remnants influences their modulation of human monocyte activation.

  International journal of vascular medicine 20120101

• 3',4'-didemethylnobiletin induces phase II detoxification gene expression and modulates PI3K/Akt signaling in PC12 cells.

  Free radical biology & medicine 20120101

• Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• A novel folate-modified self-microemulsifying drug delivery system of curcumin for colon targeting.

  International journal of nanomedicine 20120101

• Isolation and characterization of activators of ERK/MAPK from citrus plants.

  International journal of molecular sciences 20120101

• Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells.

  BMC complementary and alternative medicine 20120101

• Development of an inflammation-associated colorectal cancer model and its application for research on carcinogenesis and chemoprevention.

  International journal of inflammation 20120101

• Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents.

  Asian Pacific journal of cancer prevention : APJCP 20120101

• Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.

  Frontiers in microbiology 20120101

• Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation.

  PPAR research 20120101

• Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects.

  Oxidative medicine and cellular longevity 20120101

• Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis.

  Journal of pharmacological sciences 20120101

• Inhibition of nitric oxide production and inducible nitric oxide synthase expression by a polymethoxyflavone from young fruits of Citrus unshiu in rat primary astrocytes.

  Bioscience, biotechnology, and biochemistry 20120101

• Nobiletin suppresses adipogenesis by regulating the expression of adipogenic transcription factors and the activation of AMP-activated protein kinase (AMPK).

  Journal of agricultural and food chemistry 20111228

• Permeability determination and pharmacokinetic study of nobiletin in rat plasma and brain by validated high-performance liquid chromatography method.

  Fitoterapia 20111201

• B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production.

  Bioorganic & medicinal chemistry 20111201

• [Identification of metabolites of nobiletin in rats using ultra-performance liquid chromatography coupled with triple-quadrupole mass spectrometry].

  Yao xue xue bao = Acta pharmaceutica Sinica 20111201

• In vitro metabolism of nobiletin, a polymethoxy-flavonoid, by human liver microsomes and cytochrome P450.

  Xenobiotica; the fate of foreign compounds in biological systems 20111101

• Nobiletin, a polymethoxylated flavonoid from citrus, shows anti-angiogenic activity in a zebrafish in vivo model and HUVEC in vitro model.

  Journal of cellular biochemistry 20111101

• Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination.

  Analytica chimica acta 20111031

• Development of high-energy amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability.

  Journal of pharmaceutical sciences 20110901

• Nobiletin metabolites: synthesis and inhibitory activity against matrix metalloproteinase-9 production.

  Bioorganic & medicinal chemistry letters 20110801

• High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound.

  Analytical and bioanalytical chemistry 20110701

• Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretion.

  Journal of agricultural and food chemistry 20110511

• Citrus flavonoid 5-demethylnobiletin suppresses scavenger receptor expression in THP-1 cells and alters lipid homeostasis in HepG2 liver cells.

  Molecular nutrition & food research 20110501

• Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance.

  Diabetes 20110501

• Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.

  Bioorganic & medicinal chemistry 20110501

• Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin.

  Life sciences 20110328

• Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).

  Bioorganic & medicinal chemistry 20110315

• PET imaging of nobiletin based on a practical total synthesis.

  Chemical communications (Cambridge, England) 20110314

• Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid.

  Journal of agricultural and food chemistry 20110309

• Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry.

  Journal of agricultural and food chemistry 20110112

• Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin.

  Physiology & behavior 20110110

• Nordihydroguaiaretic Acid from Creosote Bush (Larrea tridentata) Mitigates 12-O-Tetradecanoylphorbol-13-Acetate-Induced Inflammatory and Oxidative Stress Responses of Tumor Promotion Cascade in Mouse Skin.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Suppressive Effect on Lipopolysaccharide-Induced Proinflammatory Mediators by Citrus aurantium L. in Macrophage RAW 264.7 Cells via NF-κB Signal Pathway.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells.

  Molecular and cellular biochemistry 20110101

• Nutraceuticals: do they represent a new era in the management of osteoarthritis? - a narrative review from the lessons taken with five products.

  Osteoarthritis and cartilage 20110101

• Nobiletin, a polymethoxy flavonoid, suppresses bone resorption by inhibiting NFκB-dependent prostaglandin E synthesis in osteoblasts and prevents bone loss due to estrogen deficiency.

  Journal of pharmacological sciences 20110101

• Effects of nobiletin on PhIP-induced prostate and colon carcinogenesis in F344 rats.

  Nutrition and cancer 20110101

• The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

  International journal of molecular sciences 20110101

• Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes.

  Lipids in health and disease 20110101

• Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-κB, iNOS, and TNF-α expression and reduction of MDA accumulation.

  Molecular vision 20110101

• Honeybee royal jelly and nobiletin stimulate CRE-mediated transcription in ERK-independent and -dependent fashions, respectively, in PC12D cells.

  Journal of pharmacological sciences 20110101

• Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat.

  PloS one 20110101

• Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance.

  Cardiovascular diabetology 20110101

• Evaluation of the anti-inflammatory activity of Aegle marmelos (Bilwa) root.

  Indian journal of pharmacology 20110101

• Effect of sulindac sulfide on metallohydrolases in the human colon cancer cell line HT-29.

  PloS one 20110101

• Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice.

  Pharmacognosy research 20110101

• A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells.

  PloS one 20110101

• Flavonoids: A versatile source of anticancer drugs.

  Pharmacognosy reviews 20110101

• Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells.

  PloS one 20110101

• Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p'-DDT in U937 macrophages.

  Archives of toxicology 20101201

• Nobiletin, a citrus polymethoxyflavonoid, suppresses multiple angiogenesis-related endothelial cell functions and angiogenesis in vivo.

  Cancer science 20101101

• Protective effects of the citrus flavanones to PC12 cells against cytotoxicity induced by hydrogen peroxide.

  Neuroscience letters 20101022

• Isolation and identification of polymethoxyflavones from the hybrid Citrus, hallabong.

  Journal of agricultural and food chemistry 20100908

• Study of nobiletin binding to bovine serum albumin by capillary electrophoresis-frontal analysis and circular dichroism.

  Biomedical chromatography : BMC 20100901

• Simultaneous determination of flavonoids in different parts of Citrus reticulata 'Chachi' fruit by high performance liquid chromatography-photodiode array detection.

  Molecules (Basel, Switzerland) 20100805

• Dual effects of nobiletin, a citrus polymethoxy flavone, on catecholamine secretion in cultured bovine adrenal medullary cells.

  Journal of neurochemistry 20100801

• Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice.

  Biochemical pharmacology 20100601

• Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats.

  Experimental biology and medicine (Maywood, N.J.) 20100601

• Prevention of UV-induced skin damages by 11,14,17-eicosatrienoic acid in hairless mice in vivo.

  Journal of Korean medical science 20100601

• Overcoming multidrug resistance in human cancer cells by natural compounds.

  Toxins 20100601

• Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines ( Citrus reticulata Blanco cv. Sainampueng) from Northern Thailand.

  Journal of agricultural and food chemistry 20100526

• [Preventive action of nobiletin, a constituent of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, against amyloid-beta peptide-induced neurotoxicity expression and memory impairment].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100401

• [Isolation and purification of flavones from Murraya exotica L. by high-speed counter-current chromatography].

  Se pu = Chinese journal of chromatography 20100401

• Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells.

  Cancer investigation 20100301

• Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook.

  Molecules (Basel, Switzerland) 20100226

• Nobiletin metabolite, 3',4'-dihydroxy-5,6,7,8-tetramethoxyflavone, inhibits LDL oxidation and down-regulates scavenger receptor expression and activity in THP-1 cells.

  Biochimica et biophysica acta 20100201

• [Study on the contents of flavonoids in Citrus reticulata 'Chachi' from various habitats and different collecting periods].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100201

• Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice.

  Chemico-biological interactions 20100127

• Anti-inflammatory effects of licorice and roasted licorice extracts on TPA-induced acute inflammation and collagen-induced arthritis in mice.

  Journal of biomedicine & biotechnology 20100101

• Hepatoprotective effects of flavonoids from shekwasha (Citrus depressa) against D-galactosamine-induced liver injury in rats.

  Journal of nutritional science and vitaminology 20100101

• Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources.

  BMC pharmacology 20100101

• Induction of apoptosis in human cervical carcinoma HeLa cells by polymethoxylated flavone-rich Citrus grandis Osbeck (Dangyuja) leaf extract.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101

• Clinical physiology and mechanism of dizocilpine (MK-801): electron transfer, radicals, redox metabolites and bioactivity.

  Oxidative medicine and cellular longevity 20100101

• Evaluation of the effect of lime fruit juice on the anticoagulant effect of warfarin.

  Journal of young pharmacists : JYP 20100101

• Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation.

  Biological & pharmaceutical bulletin 20100101

• Methylation of dietary flavones increases their metabolic stability and chemopreventive effects.

  International journal of molecular sciences 20091101

• Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.

  Brain research 20091027

• Modified Wendan Decoction can Attenuate Neurotoxic Action Associated with Alzheimer's Disease.

  Evidence-based complementary and alternative medicine : eCAM 20090901

• Fingerprinting alterations of secondary metabolites of tangerine peels during growth by HPLC-DAD and chemometric methods.

  Analytica chimica acta 20090901

• 4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.

  Biochemistry 20090818

• Simultaneous determination of five bioactive flavonoids in pericarpium Citri reticulatae from china by high-performance liquid chromatography with dual wavelength detection.

  Journal of agricultural and food chemistry 20090812

• Nobiletin, a dietary phytochemical, inhibits vascular smooth muscle cells proliferation via calcium-mediated c-Jun N-terminal kinases pathway.

  European journal of pharmacology 20090801

• An updated review of tyrosinase inhibitors.

  International journal of molecular sciences 20090601

• [Effect of nobiletin on K562 cells xenograft in nude mice].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090601

• [Inhibition effect and its mechanism of nobiletin on proliferation of lung cancer cells].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20090501

• Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion.

  Bioorganic & medicinal chemistry letters 20090401

• Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis.

  Molecular nutrition & food research 20090301

• [Preparation of self-assemble nobiletin proliposomes and its pharmacokinetics in rats].

  Yao xue xue bao = Acta pharmaceutica Sinica 20090201

• Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer.

  Bioorganic & medicinal chemistry 20090101

• Effect of natsudaidain isolated from Citrus plants on TNF-alpha and cyclooxygenase-2 expression in RBL-2H3 cells.

  The Journal of pharmacy and pharmacology 20090101

• Characterization of SV-40 Tag rats as a model to study prostate cancer.

  BMC cancer 20090101

• Arachidonic acid increases matrix metalloproteinase 9 secretion and expression in human monocytic MonoMac 6 cells.

  Lipids in health and disease 20090101

• Colorectal carcinogenesis: Review of human and experimental animal studies.

  Journal of carcinogenesis 20090101

• Chemoprevention with phytochemicals targeting inducible nitric oxide synthase.

  Forum of nutrition 20090101

• Citrus auraptene suppresses cyclin D1 and significantly delays N-methyl nitrosourea induced mammary carcinogenesis in female Sprague-Dawley rats.

  BMC cancer 20090101

• Pinellia ternata, Citrus reticulata, and their combinational prescription inhibit eosinophil infiltration and airway hyperresponsiveness by suppressing CCR3+ and Th2 cytokines production in the ovalbumin-induced asthma model.

  Mediators of inflammation 20090101

• Chinese medicines as a resource for liver fibrosis treatment.

  Chinese medicine 20090101

• Immunomodulatory responses of peripheral blood mononuclear cells from multiple sclerosis patients upon in vitro incubation with the flavonoid luteolin: additive effects of IFN-beta.

  Journal of neuroinflammation 20090101

• Alleviation and prevention of severe allergic rhinitis and conjunctivitis following long-term lemon juice use: a case report.

  Cases journal 20090101

• Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1.

  European journal of pharmacology 20081214

• Anti-inflammatory and antitumor promotional effects of a novel urinary metabolite, 3',4'-didemethylnobiletin, derived from nobiletin.

  Carcinogenesis 20081201

• Investigation of heat treating conditions for enhancing the anti-inflammatory activity of citrus fruit (Citrus reticulata) peels.

  Journal of agricultural and food chemistry 20080910

• Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease.

  The Journal of pharmacology and experimental therapeutics 20080901

• [Pharmacological action of nobiletin, a component of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, and its application for development of functional foods].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20080901

• Suppressive Effects of Selected Food Phytochemicals on CD74 Expression in NCI-N87 Gastric Carcinoma Cells.

  Journal of clinical biochemistry and nutrition 20080901

• [Effect of nobiletin on tubulin polymerization in vitro].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

• Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice.

  Biochemical and biophysical research communications 20080822

• Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line A549 in vitro and in vivo.

  Cancer biology & therapy 20080601

• Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice.

  Carcinogenesis 20080501

• Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-kappaB, AP-1, and Sp1 activation.

  Biochemical pharmacology 20080401

• Distribution of nobiletin chitosan-based microemulsions in brain following i.v. injection in mice.

  International journal of pharmaceutics 20080320

• Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells.

  Bioorganic & medicinal chemistry 20080315

• LPS-induced IL-6, IL-8, VCAM-1, and ICAM-1 expression in human lymphatic endothelium.

  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20080201

• A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells.

  Biochemical and biophysical research communications 20080201

• Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus.

  European journal of pharmacology 20080114

• Validated reversed phase LC method for quantitative analysis of polymethoxyflavones in citrus peel extracts.

  Journal of separation science 20080101

• Minerals, phenolic compounds, and antioxidant capacity of citrus peel extract by hot water.

  Journal of food science 20080101

• Inhibition of oral carcinogenesis by citrus flavonoids.

  Nutrition and cancer 20080101

• Anti-inflammatory effects of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) in animal models.

  Chinese medicine 20080101

• Preparation of nobiletin in self-microemulsifying systems and its intestinal permeability in rats.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20080101

• Inflammaging as a prodrome to Alzheimer's disease.

  Journal of neuroinflammation 20080101

• A citrus polymethoxy flavonoid, nobiletin inhibits sebum production and sebocyte proliferation, and augments sebum excretion in hamsters.

  The Journal of investigative dermatology 20071201

• Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3.

  Biopharmaceutics & drug disposition 20071201

• Comparative study on nobiletin metabolism with liver microsomes from rats, Guinea pigs and hamsters and rat cytochrome p450.

  Biological & pharmaceutical bulletin 20071201

• Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells.

  Pharmaceutical research 20071001

• Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?

  Seminars in cancer biology 20071001

• Comparison of two sample preconcentration strategies for the sensitivity enhancement of flavonoids found in Chinese herbal medicine in micellar electrokinetic chromatography with UV detection.

  Journal of chromatography. A 20070928

• Anti-inflammatory property of the urinary metabolites of nobiletin in mouse.

  Bioorganic & medicinal chemistry letters 20070915

• Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice.

  Journal of pharmacological sciences 20070901

• Antimicrobial activity of wax and hexane extracts from Citrus spp. peels.

  Memorias do Instituto Oswaldo Cruz 20070901

• Nobiletin from citrus fruit peel inhibits the DNA-binding activity of NF-kappaB and ROS production in LPS-activated RAW 264.7 cells.

  Journal of ethnopharmacology 20070815

• Effects of TNF-alpha on leukocyte adhesion molecule expressions in cultured human lymphatic endothelium.

  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20070701

• Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells.

  Bioscience, biotechnology, and biochemistry 20070701

• Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells.

  Cancer letters 20070618

• Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes.

  Biochemical and biophysical research communications 20070601

• [Characteristics of nobiletin-loaded nanoemulsion and its in vivo distribution in mice].

  Yao xue xue bao = Acta pharmaceutica Sinica 20070601

• Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.

  Bioorganic & medicinal chemistry 20070515

• Identification of polymethoxylated flavones from green tangerine peel (Pericarpium Citri Reticulatae Viride) by chromatographic and spectroscopic techniques.

  Journal of pharmaceutical and biomedical analysis 20070509

• Nobiletin, a citrus flavonoid, reverses learning impairment associated with N-methyl-D-aspartate receptor antagonism by activation of extracellular signal-regulated kinase signaling.

  The Journal of pharmacology and experimental therapeutics 20070501

• Quality control and discrimination of pericarpium citri reticulatae and pericarpium citri reticulatae viride based on high-performance liquid chromatographic fingerprints and multivariate statistical analysis.

  Analytica chimica acta 20070411

• Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cells.

  Journal of agricultural and food chemistry 20070404

• Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells.

  Cancer science 20070401

• Correlation between flavonoid content and the NO production inhibitory activity of peel extracts from various citrus fruits.

  Biological & pharmaceutical bulletin 20070401

• Chemopreventive effects of orange peel extract (OPE). I: OPE inhibits intestinal tumor growth in ApcMin/+ mice.

  Journal of medicinal food 20070301

• Chemopreventive effects of orange peel extract (OPE). II: OPE inhibits atypical hyperplastic lesions in rodent mammary gland.

  Journal of medicinal food 20070301

• Simultaneous analysis of eight bioactive compounds in Danning tablet by HPLC-ESI-MS and HPLC-UV.

  Journal of pharmaceutical and biomedical analysis 20070219

• Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070201

• Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts.

  Journal of enzyme inhibition and medicinal chemistry 20070201

• Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts.

  Journal of enzyme inhibition and medicinal chemistry 20070201

• Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells.

  Biochemical pharmacology 20070115

• Determination of polymethoxylated flavones in peels of selected Jamaican and Mexican citrus (Citrus spp.) cultivars by high-performance liquid chromatography.

  Biomedical chromatography : BMC 20070101

• Citrus nobiletin suppresses bone loss in ovariectomized ddY mice and collagen-induced arthritis in DBA/1J mice: possible involvement of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis regulation.

  BioFactors (Oxford, England) 20070101

• Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells.

  BioFactors (Oxford, England) 20070101

• Comparison of supercritical fluid chromatography and liquid chromatography for the separation of urinary metabolites of nobiletin with chiral and non-chiral stationary phases.

  Biomedical chromatography : BMC 20061101

• Insulin-sensitizing and anti-proliferative effects of Argania spinosa seed extracts.

  Evidence-based complementary and alternative medicine : eCAM 20060901

• [Antitumor effects of nobiletin on Heps and its mechanism].

  Yao xue xue bao = Acta pharmaceutica Sinica 20060801

• Nobiletin restoring beta-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats.

  Neuroscience letters 20060612

• Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China.

  Plant foods for human nutrition (Dordrecht, Netherlands) 20060601

• Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells.

  FEBS letters 20060529

• Antagonistic effects of nobiletin, a polymethoxyflavonoid, on eosinophilic airway inflammation of asthmatic rats and relevant mechanisms.

  Life sciences 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells.

  Biological chemistry 20060401

• Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen.

  International journal of molecular medicine 20060301

• Identification of nobiletin metabolites in mouse urine.

  Molecular nutrition & food research 20060301

• Liquid chromatography/mass spectrometry and liquid chromatography/nuclear magnetic resonance as complementary analytical techniques for unambiguous identification of polymethoxylated flavones in residues from molecular distillation of orange peel oils (Citrus sinensis).

  Journal of agricultural and food chemistry 20060125

• Nobiletin: efficient and large quantity isolation from orange peel extract.

  Biomedical chromatography : BMC 20060101

• Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities.

  Biochemical and biophysical research communications 20051202

• Mechanism of neurotrophic action of nobiletin in PC12D cells.

  Biochemistry 20051025

• Preparative isolation and purification of polymethoxylated flavones from Tangerine peel using high-speed counter-current chromatography.

  Journal of chromatography. A 20051007

• Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B.

  Drug metabolism and disposition: the biological fate of chemicals 20050401

• Effect of flavones on rat brain and lung matrix metalloproteinase activity measured by film in-situ zymography.

  The Journal of pharmacy and pharmacology 20050401

• [Chemical study of citrus plants in the search for cancer chemopreventive agents].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20050301

• Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells.

  Bioscience, biotechnology, and biochemistry 20050201

• Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages.

  Atherosclerosis 20050101

• Anti-hepatitis C virus effect of citrus unshiu peel and its active ingredient nobiletin.

  The American journal of Chinese medicine 20050101

• Metabolite fingerprinting in transgenic Nicotiana tabacum altered by the Escherichia coli glutamate dehydrogenase gene.

  Journal of biomedicine & biotechnology 20050101

• Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.

  British journal of pharmacology 20041201

• Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo.

  Cancer science 20041201

• Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.

  Journal of natural products 20041101

• Prevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid, nobiletin, in human keratinocytes in vivo and in vitro.

  Biochemical pharmacology 20040801

• Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription.

  Mutation research 20040713

• Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin.

  Molecular cancer therapeutics 20040701

• Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: antiproliferative effects, induction of apoptosis and cell cycle deregulation.

  Alimentary pharmacology & therapeutics 20040701

• Changes in the levels of polymethoxyflavones and flavanones as part of the defense mechanism of Citrus sinensis (cv. Valencia Late) fruits against Phytophthora citrophthora.

  Journal of agricultural and food chemistry 20040407

• ZD6126 inhibits orthotopic growth and peritoneal carcinomatosis in a mouse model of human gastric cancer.

  British journal of cancer 20040209

• Rapid analysis of gene expression changes caused by liver carcinogens and chemopreventive agents using a newly developed three-dimensional microarray system.

  Cancer science 20040201

• Cancer prevention by antioxidants.

  BioFactors (Oxford, England) 20040101

• Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats.

  BioFactors (Oxford, England) 20040101

• Effect of extraction method on the concentrations of selected bioactive compounds in mandarin juice.

  Journal of agricultural and food chemistry 20031203

• Urinary metabolites of nobiletin orally administered to rats.

  Chemical & pharmaceutical bulletin 20031201

• Fungicidal potential of methoxylated flavones from citrus for in vitro control of Colletotrichum gloeosporioides, causal agent of anthracnose disease in tropical fruits.

  Pest management science 20031101

• Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages.

  Biochemical pharmacology 20030615

• Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-gamma-induced IkappaB degradation in RAW264.7 macrophages.

  Cancer letters 20030530

• Insect antifeedant activity of flavones and chromones against Spodoptera litura.

  Journal of agricultural and food chemistry 20030115

• Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells.

  Journal of cancer research and clinical oncology 20021001

• Nobiletin as a tyrosinase inhibitor from the peel of Citrus fruit.

  Biological & pharmaceutical bulletin 20020601

• Increasing resistance against Phytophthora citrophthora in tangelo Nova fruits by modulating polymethoxyflavones levels.

  Journal of agricultural and food chemistry 20020508

• Genetic toxicity of a standardized mixture of citrus polymethoxylated flavones.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020501

• Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells.

  Cancer research 20020215

• Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease.

  Biochemical pharmacology 20020115

• Characteristic rat tissue accumulation of nobiletin, a chemopreventive polymethoxyflavonoid, in comparison with luteolin.

  BioFactors (Oxford, England) 20020101

• Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4.

  Chemical research in toxicology 20011201

• The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice.

  Japanese journal of cancer research : Gann 20011201

• Immunotoxicity of a standardized citrus polymethoxylated flavone extract.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20011101

• Dietary administration of citrus nobiletin inhibits azoxymethane-induced colonic aberrant crypt foci in rats.

  Life sciences 20010713

• Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants.

  Cancer letters 20010210

• Evaluation of the effects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitro.

  Neuropathology and applied neurobiology 20010201

• In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits.

  Bioscience, biotechnology, and biochemistry 20010101

• Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds.

  Biochemical pharmacology 19940803

• Inhibition of reverse transcriptases by flavonoids.

  Antiviral research 19890901