481-53-8 | Tangeretin

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$6.00	$4.00
5mg	98%	in stock	$7.00	$5.00
50mg	98%	in stock	$20.00	$14.00
250mg	98%	in stock	$95.00	$67.00
1g	98%(HPLC)	in stock	$255.00	$179.00
5g	98%	in stock	$347.00	$243.00

Description

• Catalog Number: AI50961
• Chemical Name: Tangeretin
• CAS Number: 481-53-8
• Molecular Formula: C20H20O7
• Molecular Weight: 372.3686
• MDL Number: MFCD00017438
• SMILES: COc1ccc(cc1)c1cc(=O)c2c(o1)c(OC)c(c(c2OC)OC)OC

Computed Properties

• Complexity: 540
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• XLogP3: 3

Literature

• Tangeretin inhibits the proliferation of human breast cancer cells via CYP1A1/CYP1B1 enzyme induction and CYP1A1/CYP1B1-mediated metabolism to the product 4' hydroxy tangeretin.

  Toxicology in vitro : an international journal published in association with BIBRA 20180801

• Tangeretin attenuates cisplatin-induced renal injury in rats: Impact on the inflammatory cascade and oxidative perturbations.

  Chemico-biological interactions 20161025

• In vitro effects of some flavones on human pyruvate kinase isoenzyme M2.

  Journal of biochemical and molecular toxicology 20150301

• Tangeretin ameliorates oxidative stress in the renal tissues of rats with experimental breast cancer induced by 7,12-dimethylbenz[a]anthracene.

  Toxicology letters 20140902

• Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress.

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  Food chemistry 20120915

• The composition of volatile aroma components, flavanones, and polymethoxylated flavones in Shiikuwasha (Citrus depressa Hayata) peels of different cultivation lines.

  Journal of agricultural and food chemistry 20120815

• Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice.

  Molecular and cellular endocrinology 20120706

• Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities.

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• Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors.

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• Simultaneous quantification of polymethoxylated flavones and coumarins in Fructus aurantii and Fructus aurantii immaturus using HPLC-ESI-MS/MS.

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• Phenolic constituents from the heartwood of Artocapus altilis and their tyrosinase inhibitory activity.

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• Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis.

  Journal of pharmacological sciences 20120101

• Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation.

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• Tangeretin and its metabolite 4'-hydroxytetramethoxyflavone attenuate EGF-stimulated cell cycle progression in hepatocytes; role of inhibition at the level of mTOR/p70S6K.

  British journal of pharmacology 20110401

• Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin.

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• Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).

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• Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid.

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• Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation.

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• Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry.

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• The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

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• Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes.

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• Enzymatic Synthesis of the Flavone Glucosides, Prunin and Isoquercetin, and the Aglycones, Naringenin and Quercetin, with Selective α-L-Rhamnosidase and β-D-Glucosidase Activities of Naringinase.

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  Molecules (Basel, Switzerland) 20100805

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  Molecular nutrition & food research 20100701

• Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework.

  Bioinformatics (Oxford, England) 20100615

• The flavonoid tangeretin activates the unfolded protein response and synergizes with imatinib in the erythroleukemia cell line K562.

  Molecular nutrition & food research 20100601

• Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines ( Citrus reticulata Blanco cv. Sainampueng) from Northern Thailand.

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• Managing phenol contents in crop plants by phytochemical farming and breeding-visions and constraints.

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• Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources.

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  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101

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  Journal of young pharmacists : JYP 20100101

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  Cancer research 20091201

• Methylation of dietary flavones increases their metabolic stability and chemopreventive effects.

  International journal of molecular sciences 20091101

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  Analytica chimica acta 20090901

• UPLC/Q-TOFMS/MS as a powerful technique for rapid identification of polymethoxylated flavones in Fructus aurantii.

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  Se pu = Chinese journal of chromatography 20090301

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  Bioorganic & medicinal chemistry 20090101

• Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention.

  BMC cancer 20090101

• Exogenous Cx43 expression decrease cell proliferation rate in rat hepatocarcinoma cells independently of functional gap junction.

  Cancer cell international 20090101

• Investigation of heat treating conditions for enhancing the anti-inflammatory activity of citrus fruit (Citrus reticulata) peels.

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• Suppressive Effects of Selected Food Phytochemicals on CD74 Expression in NCI-N87 Gastric Carcinoma Cells.

  Journal of clinical biochemistry and nutrition 20080901

• Activation of pregnane X receptor and induction of MDR1 by dietary phytochemicals.

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• Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes.

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• Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells.

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  Anti-cancer agents in medicinal chemistry 20080201

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  Journal of separation science 20080101

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  Journal of food science 20080101

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  Memorias do Instituto Oswaldo Cruz 20070901

• Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells.

  Cancer letters 20070618

• Inhibitors of stress-activated protein/mitogen-activated protein kinase pathways.

  Current opinion in pharmacology 20070601

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• Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.

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• Characterization of polymethoxylated flavones in Fructus aurantii by liquid chromatography with atmospheric pressure chemical ionization combined with tandem mass spectrometry.

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• Quality control and discrimination of pericarpium citri reticulatae and pericarpium citri reticulatae viride based on high-performance liquid chromatographic fingerprints and multivariate statistical analysis.

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• Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cells.

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  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070201

• Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells.

  Biochemical pharmacology 20070115

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  American journal of physiology. Cell physiology 20070101

• Determination of polymethoxylated flavones in peels of selected Jamaican and Mexican citrus (Citrus spp.) cultivars by high-performance liquid chromatography.

  Biomedical chromatography : BMC 20070101

• Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells.

  BioFactors (Oxford, England) 20070101

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  Lipids 20040201

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  Drug metabolism and disposition: the biological fate of chemicals 20040101

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  Nutrition and cancer 20040101

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  Reproductive toxicology (Elmsford, N.Y.) 20030101

• Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20021101

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  Carcinogenesis 20021001

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  Melanoma research 20020401

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  Acta pharmacologica Sinica 20020101

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  Advances in experimental medicine and biology 20020101

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  Neuroreport 20011204

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  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20011101

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  European journal of cell biology 20010901

• Evaluation of the effects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitro.

  Neuropathology and applied neurobiology 20010201

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  Xenobiotica; the fate of foreign compounds in biological systems 19991201