481-72-1 | Aloe-emodin

Packsize	Purity	Availability	Price	Discounted Price
25mg	97%	in stock	$6.00	$4.00
250mg	97%	in stock	$11.00	$8.00
1g	98%	in stock	$33.00	$23.00
5g	97%	in stock	$60.00	$42.00
25g	97%	in stock	$180.00	$126.00
100g	97%	in stock	$592.00	$414.00

Description

• Catalog Number: AI50962
• Chemical Name: Aloe-emodin
• CAS Number: 481-72-1
• Molecular Formula: C15H10O5
• Molecular Weight: 270.2369
• MDL Number: MFCD00017373
• SMILES: OCc1cc(O)c2c(c1)C(=O)c1c(C2=O)c(O)ccc1
• NSC Number: 38628

Computed Properties

• Complexity: 421
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 1
• XLogP3: 1.8

Literature

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• The natural anthraquinones from Rheum palmatum induced the metabolic disorder of melatonin by inhibiting human CYP and SULT enzymes.

  Toxicology letters 20161116

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  Apoptosis : an international journal on programmed cell death 20120801

• Aloe-emodin inhibits adipocyte differentiation and maturation during in vitro human mesenchymal stem cell adipogenesis.

  Journal of biochemical and molecular toxicology 20120801

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• Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2.

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  European journal of medicinal chemistry 20120601

• Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120411

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  Journal of pharmaceutical and biomedical analysis 20120325

• The endoplasmic reticulum stress response is involved in apoptosis induced by aloe-emodin in HK-2 cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301

• Apoptosis by aloe-emodin is mediated through down-regulation of calpain-2 and ubiquitin-protein ligase E3A in human hepatoma Huh-7 cells.

  Cell biology international 20120201

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• Comparison of dispersive liquid-liquid microextraction based on organic solvent and ionic liquid combined with high-performance liquid chromatography for the analysis of emodin and its metabolites in urine samples.

  Journal of separation science 20120101

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  Pharmacology 20120101

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  International journal of molecular sciences 20120101

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  Life sciences 20111121

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  Fitoterapia 20110401

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  Journal of cellular biochemistry 20110401

• Novel methodology for the extraction and identification of natural dyestuffs in historical textiles by HPLC-UV-Vis-ESI MS. Case study: chasubles from the Wawel Cathedral collection.

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  Bioorganic & medicinal chemistry 20110101

• In vitro study of the PLA2 inhibition and antioxidant activities of Aloe vera leaf skin extracts.

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  Talanta 20101215

• Photodynamic activity of aloe-emodin induces resensitization of lung cancer cells to anoikis.

  European journal of pharmacology 20101201

• Down-regulation of MMP-2 through the p38 MAPK-NF-kappaB-dependent pathway by aloe-emodin leads to inhibition of nasopharyngeal carcinoma cell invasion.

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• Antitumor properties of aloe-emodin and induction of transglutaminase 2 activity in B16-F10 melanoma cells.

  Life sciences 20100828

• Temperature-assisted ionic liquid dispersive liquid-liquid microextraction combined with high performance liquid chromatography for the determination of anthraquinones in Radix et Rhizoma Rhei samples.

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  Journal of separation science 20100601

• Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway.

  Cancer letters 20100501

• Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells through the inhibition of gene expression of matrix metalloproteinase-9.

  International journal of oncology 20100501

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  Anticancer research 20100301

• Screening of Kit inhibitors: suppression of Kit signaling and melanogenesis by emodin.

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  BMC gastroenterology 20100101

• The molecular effects of aloe-emodin (AE)/liposome-AE on human nonmelanoma skin cancer cells and skin permeation.

  Chemical research in toxicology 20091201

• Characterization of emodin metabolites in Raji cells by LC-APCI-MS/MS.

  Bioorganic & medicinal chemistry 20091101

• Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells.

  Anticancer research 20091101

• Metabolism and pharmacokinetics of anthraquinones in Rheum palmatum in rats and ex vivo antioxidant activity.

  Planta medica 20091001

• Induction of defence mechanisms in grapevine leaves by emodin- and anthraquinone-rich plant extracts and their conferred resistance to downy mildew.

  Plant physiology and biochemistry : PPB 20090901

• Effective constituents in Xiexin Decoction for anti-inflammation.

  Journal of ethnopharmacology 20090817

• Aloe-emodin-induced DNA fragmentation in the mouse in vivo comet assay.

  Mutation research 20090801

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  Yao xue xue bao = Acta pharmaceutica Sinica 20090801

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• Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells.

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• Investigations of free anthraquinones from rhubarb against alpha-naphthylisothiocyanate-induced cholestatic liver injury in rats.

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• [Simultaneous determination of anthraquinones in Liuwei'anxiao capsules by HPLC].

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• Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages.

  Bioscience, biotechnology, and biochemistry 20090423

• Pharmacokinetics of anthraquinones in Xiexin decoction and in different combinations of its constituent herbs.

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• Anti-angiogenic effects of rhubarb and its anthraquinone derivatives.

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• [The anti-proliferation and anti-migration dual effects of aloe-emodin on KB cells and its mechanism].

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• Intestinal absorption of aloin, aloe-emodin, and aloesin; A comparative study using two in vitro absorption models.

  Nutrition research and practice 20090101

• Is senna laxative use associated to cathartic colon, genotoxicity, or carcinogenicity?

  Journal of toxicology 20090101

• A modified method for isolation of rhein from senna.

  Indian journal of pharmaceutical sciences 20090101

• Antitumor and antimetastatic actions of anthrone-C-glucoside, cassialoin isolated from Cassia garrettiana heartwood in colon 26-bearing mice.

  Cancer science 20081101

• Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71.

  International journal of antimicrobial agents 20081001

• Anthraquinone-benzisochromanquinone dimers from the roots of Berchemia floribunda.

  Chemical & pharmaceutical bulletin 20080901

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  European journal of medicinal chemistry 20080601

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  Oral oncology 20080601

• Anti-proliferative effects of estrogen receptor-modulating compounds isolated from Rheum palmatum.

  Archives of pharmacal research 20080601

• Suppression of C-myc expression associates with anti-proliferation of aloe-emodin on gastric cancer cells.

  Cancer investigation 20080501

• [Studies on chemical constituents and volatile oil of Xiaochengqi decoction].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501

• Modeling the interactions of herbal drugs to beta-ketoacyl ACP synthase of Mycobacterium tuberculosis H37Rv.

  Journal of biomolecular structure & dynamics 20080401

• Preparation of 1,8-di-O-alkylaloe-emodins and 15-amino-, 15-thiocyano-, and 15-selenocyanochrysophanol derivatives from aloe-emodin and studying their cytotoxic effects.

  Chemical & pharmaceutical bulletin 20080401

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  Toxicology in vitro : an international journal published in association with BIBRA 20080301

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  Yao xue xue bao = Acta pharmaceutica Sinica 20080201

• Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography.

  Talanta 20080115

• Studies of the interaction between Aloe-emodin and DNA and preparation of DNA biosensor for detection of PML-RARalpha fusion gene in acute promyelocytic leukemia.

  Talanta 20080115

• Inhibitory effect of aloe-emodin on metastasis potential in HO-8910PM cell line.

  Journal of Asian natural products research 20080101

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  BMC pharmacology 20080101

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  PPAR research 20080101

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  Indian journal of dermatology 20080101

• Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin.

  Nutrition research and practice 20080101

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  Journal of chromatography. A 20071228

• Inhibitory effect of schisandrin B on gastric cancer cells in vitro.

  World journal of gastroenterology 20071228

• Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation.

  Acta pharmacologica Sinica 20071201

• Chaperones are the target in aloe-emodin-induced human lung nonsmall carcinoma H460 cell apoptosis.

  European journal of pharmacology 20071114

• Aloe-emodin-induced apoptosis in human gastric carcinoma cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071101

• Aloe-emodin suppressed NMDA-induced apoptosis of retinal ganglion cells through regulation of ERK phosphorylation.

  Phytotherapy research : PTR 20071101

• Aloe-emodin induces in vitro G2/M arrest and alkaline phosphatase activation in human oral cancer KB cells.

  Oral oncology 20071001

• In situ synthesis of molecularly imprinted polymers on glass microspheres in a column.

  Analytical and bioanalytical chemistry 20071001

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  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071001

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  Medicinal research reviews 20070901

• Aloe emodin inhibits the cytotoxic action of tumor necrosis factor.

  European journal of pharmacology 20070730

• Simultaneous determination and pharmacokinetic studies of aloe emodin and chrysophanol in rats after oral administration of Da-Cheng-Qi decoction by high-performance liquid chromatography.

  Biomedical chromatography : BMC 20070701

• Affinity chromatography with immobilized DNA stationary phase for biological fingerprinting analysis of traditional Chinese medicines.

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  Planta medica 20070601

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  Biomedical chromatography : BMC 20070501

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  Bioscience, biotechnology, and biochemistry 20070501

• Application of 1-alkyl-3-methylimidazolium-based ionic liquids as background electrolyte in capillary zone electrophoresis for the simultaneous determination of five anthraquinones in Rhubarb.

  Talanta 20070430

• Aloe-emodin metabolites protected N-methyl-d-aspartate-treated retinal ganglion cells by Cu-Zn superoxide dismutase.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070401

• Anticancer effects of aloe-emodin on HepG2 cells: Cellular and proteomic studies.

  Proteomics. Clinical applications 20070401

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  Journal of chromatography. A 20070323

• Simultaneous determination of eight active components in Chinese medicine 'YIQING' capsule using high-performance liquid chromatography.

  Journal of pharmaceutical and biomedical analysis 20070104

• Rapid separation and determination of structurally related anthraquinones in Rhubarb by pressurized capillary electrochromatography.

  Journal of pharmaceutical and biomedical analysis 20070104

• Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin.

  Cancer biology & therapy 20070101

• Determination of the anthraquinones aloe-emodin and aloin-A by liquid chromatography with mass spectrometric and diode array detection.

  Journal of AOAC International 20070101

• Preparative isolation and purification of hydroxyanthraquinones from Rheum tanguticum Maxim. on normal phase silica gel: using a Flash Master Personal system.

  Preparative biochemistry & biotechnology 20070101

• Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice,aloe Barbadensis Leaf Polysaccharides, Aloe Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract.

  International journal of toxicology 20070101

• Effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice.

  The American journal of Chinese medicine 20070101

• Virucidal agents in the eve of manorapid synergy.

  GMS Krankenhaushygiene interdisziplinar 20070101

• Evaluation of the anti-angiogenic effect of aloe-emodin.

  Cellular and molecular life sciences : CMLS 20061201

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  Journal of chromatography. A 20060804

• Aloe-emodin induced DNA damage through generation of reactive oxygen species in human lung carcinoma cells.

  Cancer letters 20060728

• Isolation and inhibitory activity against ERK phosphorylation of hydroxyanthraquinones from rhubarb.

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  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060201

• Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway.

  The Journal of urology 20060101

• Aloe-emodin affects the levels of cytokines and functions of leukocytes from Sprague-Dawley rats.

  In vivo (Athens, Greece) 20060101

• Effect of inhibition of aloe-emodin on N-acetyltransferase activity and gene expression in human malignant melanoma cells (A375.S2).

  Melanoma research 20051201

• Spectroscopic characterization of effective components anthraquinones in Chinese medicinal herbs binding with serum albumins.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051101

• Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds.

  Antiviral research 20051001

• Effects of tannins and related polyphenols on methicillin-resistant Staphylococcus aureus.

  Phytochemistry 20050901

• [Screening of antineoplastic components in Radix et Rhizoma Rhei using chromatographic fingerprints].

  Se pu = Chinese journal of chromatography 20050901

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  Electrophoresis 20050801

• [Studies on the chemical constituents in herb of Mentha haplocalyx].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050701

• Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin.

  Cellular and molecular life sciences : CMLS 20050601

• Aloe emodin-induced apoptosis in t-HSC/Cl-6 cells involves a mitochondria-mediated pathway.

  Basic & clinical pharmacology & toxicology 20050601

• Simultaneous determination of anthraquinones in Rhubarb by pressurized liquid extraction and capillary zone electrophoresis.

  Electrophoresis 20050501

• Simultaneous determination of anthraquinones, their 8-beta-D-glucosides, and sennosides of Rhei Rhizoma by capillary electrophoresis.

  Chemical & pharmaceutical bulletin 20050501

• Release of nucleophosmin from the nucleus: Involvement in aloe-emodin-induced human lung non small carcinoma cell apoptosis.

  International journal of cancer 20050301

• Anti-glioma action of aloe emodin: the role of ERK inhibition.

  Cellular and molecular life sciences : CMLS 20050301

• Activity of wen-pi-tang, and purified constituents of rhei rhizoma and glycyrrhizae radix against glucose-mediated protein damage.

  The American journal of Chinese medicine 20050101

• Analysis of the anthraquinones aloe-emodin and aloin by gas chromatography/mass spectrometry.

  International immunopharmacology 20041220

• Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells.

  International immunopharmacology 20041220

• Preparative isolation and purification of hydroxyanthraquinones and cinnamic acid from the chinese medicinal herb Rheum officinale Baill. by high-speed counter-current chromatography.

  Journal of chromatography. A 20041015

• Anthraquinones isolated from Cassia tora (Leguminosae) seed show an antifungal property against phytopathogenic fungi.

  Journal of agricultural and food chemistry 20041006

• [Determination of active anthraquinones in Rheum and its tea preparations by micellar electrokinetic capillary electrophoresis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040901

• Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040801

• Aloe-emodin prevents cytokine-induced tumor cell death: the inhibition of auto-toxic nitric oxide release as a potential mechanism.

  Cellular and molecular life sciences : CMLS 20040701

• Determination of active ingredients in Huangdan Yinchen Keli by CZE with amperometric detection.

  Journal of pharmaceutical and biomedical analysis 20040629

• Identification and determination of active anthraquinones in Chinese teas by micellar electrokinetic capillary chromatography.

  Biomedical chromatography : BMC 20040401

• Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.

  Journal of ethnopharmacology 20040401

• Ethanol and aloe emodin alter the p53 mutational spectrum in ultraviolet radiation-induced murine skin tumors.

  Molecular carcinogenesis 20040301

• Evaluation of Rhubarb using antioxidative activity as an index of pharmacological usefulness.

  Journal of ethnopharmacology 20040301

• Determination of three compounds in Aloe vera by capillary electrophoresis.

  Biomedical chromatography : BMC 20040301

• Combined effect of aloe-emodin and chemotherapeutic agents on the proliferation of an adherent variant cell line of Merkel cell carcinoma.

  Oncology reports 20040101

• Microbial glycosylation of four free anthraquinones by Absidia coerulea.

  Biotechnology letters 20040101

• Interaction of emodin, aloe-emodin, and rhein with human serum albumin: a fluorescence spectroscopic study.

  Toxicology mechanisms and methods 20040101

• [Relationship between antibacterial activity of aloe and its anthaquinone compounds].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031101

• High-performance liquid chromatographic assay for the determination of Aloe Emodin in mouse plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031025

• Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin.

  International journal of cancer 20031010

• Aloe-emodin inhibited N-acetylation and DNA adduct of 2-aminofluorene and arylamine N-acetyltransferase gene expression in mouse leukemia L 1210 cells.

  Leukemia research 20030901

• Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell.

  International journal of cancer 20030810

• Transcriptional suppression of the HIV promoter by natural compounds.

  Antiviral research 20030301

• Determination of active components in rhubarb and study of their hydrophobicity by micellar electrokinetic chromatography.

  Bioorganic & medicinal chemistry letters 20030224

• Permeation-enhancing effect of aloe-emodin anthrone on water-soluble and poorly permeable compounds in rat colonic mucosa.

  Biological & pharmaceutical bulletin 20021201

• [Determination of six effective components in Rheum by cyclodextrin modified micellar electrokinetic chromatography].

  Yao xue xue bao = Acta pharmaceutica Sinica 20021001

• The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines.

  Life sciences 20020906

• Simultaneous determination of Aloe-emodin and Rhein by synchronous fluorescence spectroscopy.

  Journal of pharmaceutical and biomedical analysis 20020720

• Studies on the photostability and phototoxicity of aloe-emodin, emodin and rhein.

  Die Pharmazie 20020601

• [Contents of barbaloin-related compounds in aloe drinks and their change during storage].

  Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20020601

• Cytotoxicity of rhein, the active metabolite of sennoside laxatives, is reduced by multidrug resistance-associated protein 1.

  British journal of cancer 20020506

• Photochemistry and phototoxicity of aloe emodin.

  Photochemistry and photobiology 20020401

• Aloe emodin suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture.

  Pharmacology & toxicology 20020401

• The effect of aloe emodin on the proliferation of a new merkel carcinoma cell line.

  The American Journal of dermatopathology 20020201

• Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma.

  European journal of pharmacology 20011123

• Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell.

  British journal of pharmacology 20011101

• Metabolism of 1,8-dihydroxy 3-hydroxy methyl anthraquinone (aloe-emodin) isolated from the leaves of Cassia tora in albino rats.

  Phytotherapy research : PTR 20010801

• Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity.

  Bioorganic & medicinal chemistry letters 20010723

• [Effect of aloe-emodin on c-myc gene expression of cultured vascular smooth muscle cells of injured artery].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010701

• Effect of aloe-emodin on expression of proliferating cell nuclear antigen of vascular smooth muscle cells in culture after arterial injury.

  Chinese medical journal 20010601

• In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus.

  Antiviral research 20010301

• Cytotoxic and DNA damage-inducing activities of low molecular weight phenols from rhubarb.

  Anticancer research 20010101

• Antifungal activity of anthraquinone derivatives from Rheum emodi.

  Journal of ethnopharmacology 20000901

• Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus.

  Antiviral research 19920101

• In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives.

  Antiviral research 19910901