482-45-1 | Isoimperatorin

Packsize	Purity	Availability	Price	Discounted Price
5mg	≥98%	in stock	$42.00	$29.00
10mg	≥98%	in stock	$79.00	$55.00
25mg	98% by HPLC	in stock	$160.00	$112.00
50mg	98% by HPLC	in stock	$232.00	$163.00
100mg	98% by HPLC	in stock	$360.00	$252.00
500mg	98% by HPLC	in stock	$1,035.00	$724.00
1000mg	98% by HPLC	in stock	$1,621.00	$1,135.00

Description

• Catalog Number: AD22446
• Chemical Name: Isoimperatorin
• CAS Number: 482-45-1
• Molecular Formula: C16H14O4
• Molecular Weight: 270.2800
• MDL Number: MFCD00272155
• SMILES: CC(=CCOc1c2ccoc2cc2c1ccc(=O)o2)C

Computed Properties

• Complexity: 436
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• XLogP3: 3.8

Literature

• Mechanism-based inactivation of cytochrome P450 2B6 by isoimperatorin.

  Chemico-biological interactions 20150125

• Study on pharmacokinetics and tissue distribution of pteryxin in mice by ultra-pressure liquid chromatography with tandem mass spectrometry.

  Biomedical chromatography : BMC 20120701

• [Fingerprint of Angelica polymorpha by HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120301

• Furocoumarins affect hepatic cytochrome P450 and renal organic ion transporters in mice.

  Toxicology letters 20120225

• [Fingerprint analysis of Glehniae Radix by TLC].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20120201

• Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor.

  Bioorganic & medicinal chemistry 20120115

• Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation.

  Journal of natural products 20110624

• [Determination of supermolecular inclusion constants of hydroxylpropyl-beta-cylcodextrin with imperatorin and isoimperatorin by phase solubility method].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110601

• [Determination of imperatorin and isoimperatorin in cosmetics by high performance liquid chromatography-tandem mass spectrometry].

  Se pu = Chinese journal of chromatography 20110501

• Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts.

  PloS one 20110101

• Citrusosides A-D and furanocoumarins with cholinesterase inhibitory activity from the fruit peels of Citrus hystrix.

  Journal of natural products 20101129

• [Fast determination of active components in Angelica dahurica extract using capillary electrochromatography with methacrylate ester-based monolithic columns].

  Se pu = Chinese journal of chromatography 20100301

• Biotransformation of isoimperatorin and imperatorin by Glomerella cingulata and beta-secretase inhibitory activity.

  Bioorganic & medicinal chemistry 20100101

• Imperatorin is responsible for the vasodilatation activity of Angelica Dahurica var. Formosana regulated by nitric oxide in an endothelium-dependent manner.

  Chinese journal of integrative medicine 20091201

• Simultaneous determination of five coumarins in Angelicae dahuricae Radix by HPLC/UV and LC-ESI-MS/MS.

  Biomedical chromatography : BMC 20091001

• Notopterygium forbesii Boiss extract and its active constituent phenethyl ferulate attenuate pro-inflammatory responses to lipopolysaccharide in RAW 264.7 macrophages. A 'protective' role for oxidative stress?

  Chemical research in toxicology 20090801

• Coumarins from Angelica lucida L.--antibacterial activities.

  Molecules (Basel, Switzerland) 20090727

• [Chemical constituents of antibacterial activity fraction of Angelica polymorpha].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080801

• The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.

  Archives of pharmacal research 20080201

• [Studies on chemical constituents in fruit of Gardenia jasminoides].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070601

• Ethyl acetate extract from Angelica Dahuricae Radix inhibits lipopolysaccharide-induced production of nitric oxide, prostaglandin E2 and tumor necrosis factor-alphavia mitogen-activated protein kinases and nuclear factor-kappaB in macrophages.

  Pharmacological research 20070401

• Potent protective effect of isoimperatorin against aflatoxin B1-inducible cytotoxicity in H4IIE cells: bifunctional effects on glutathione S-transferase and CYP1A.

  Carcinogenesis 20061201

• Determination of liquiritin, naringin, hesperidin, thymol, imperatorin, honokiol, isoimperatorin, and magnolol in the traditional Chinese medicinal preparation Huoxiang-zhengqi liquid using high-performance liquid chromatography.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20061101

• Preparative isolation of imperatorin, oxypeucedanin and isoimperatorin from traditional Chinese herb 'bai zhi'Angelica dahurica (Fisch. ex Hoffm) Benth. et Hook using multidimensional high-speed counter-current chromatography.

  Journal of chromatography. A 20060519

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• [Studies on chemical constituents in roots of Heracleum rapula].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060201

• New cosmetic agents for skin whitening from Angelica dahurica.

  Journal of cosmetic science 20060101

• Coumarins are competitive inhibitors of cytochrome P450 1B1, with equal potency for allelic variants.

  Pharmacogenetics and genomics 20050301

• 2D NMR spectroscopic analyses of archangelicin from the seeds of Angelica archangelica.

  Acta pharmaceutica (Zagreb, Croatia) 20041201

• [Determination of coumarins content in Radix Angelicae dahuricae by HPLC and UV].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20041101

• [Determination of isoimperatorin and osthol in ganmao yixiaoshi capsule by RP-HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20041001

• [Study on coumarin compounds from Exocarpium Citri Grandis].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040801

• [Studies on quality standards of radix Angelicae dahuricae].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040701

• [Extraction of coumarins from Angelica dahurica by supercritical extraction and GC-MS analysis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040301

• Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas.

  Archives of pharmacal research 20030901

• Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells.

  Planta medica 20020501

• Inhibitors of 5alpha -reductase type I in LNCaP cells from the roots of Angelica koreana.

  Planta medica 20020201

• Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships.

  Journal of natural products 20010501

• Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides.

  Bioorganic & medicinal chemistry 19941001