48208-26-0 | Rg108

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$21.00	$15.00
5mg	98%	in stock	$53.00	$37.00
10mg	98%	in stock	$68.00	$48.00
25mg	95%	in stock	$85.00	$59.00
50mg	98%	in stock	$108.00	$76.00

Description

• Catalog Number: AB78806
• Chemical Name: Rg108
• CAS Number: 48208-26-0
• Molecular Formula: C19H14N2O4
• Molecular Weight: 334.3255
• MDL Number: MFCD08705332
• SMILES: OC(=O)[C@@H](N1C(=O)c2c(C1=O)cccc2)Cc1c[nH]c2c1cccc2

Computed Properties

• Complexity: 554
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 4
• XLogP3: 2.6

Literature

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• DNA methylation mediates persistent epileptiform activity in vitro and in vivo.

  PloS one 20130101

• Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells.

  Cellular & molecular biology letters 20121201

• DNA methyltransferase inhibitor RG108 and histone deacetylase inhibitors cooperate to enhance NB4 cell differentiation and E-cadherin re-expression by chromatin remodelling.

  Cell biology international 20121101

• New cytosine derivatives as inhibitors of DNA methylation.

  European journal of medicinal chemistry 20120901

• Epigenetic regulation of motor neuron cell death through DNA methylation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20111116

• Synthesis and biochemical evaluation of δ(2)-isoxazoline derivatives as DNA methyltransferase 1 inhibitors.

  Journal of medicinal chemistry 20111110

• Efficient non-viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells.

  PloS one 20110101

• Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors.

  Bioorganic & medicinal chemistry letters 20100201

• Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.

  Journal of immunology (Baltimore, Md. : 1950) 20090101

• Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.

  Cancer research 20060301

• Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases.

  Bioconjugate chemistry 20060101