493-09-4 | 1,4-Benzodioxan

Packsize	Purity	Availability	Price	Discounted Price
25g	98%	in stock	$10.00	$7.00
500g	98%	in stock	$171.00	$120.00

Description

• Catalog Number: AB57421
• Chemical Name: 1,4-Benzodioxan
• CAS Number: 493-09-4
• Molecular Formula: C8H8O2
• Molecular Weight: 136.1479
• MDL Number: MFCD00006821
• SMILES: C1COc2c(O1)cccc2
• NSC Number: 406705

Computed Properties

• Complexity: 99.8
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 2
• XLogP3: 2

Literature

• Design, modification and 3D QSAR studies of novel 2,3-dihydrobenzo[b][1,4]dioxin-containing 4,5-dihydro-1H-pyrazole derivatives as inhibitors of B-Raf kinase.

  Bioorganic & medicinal chemistry 20121015

• Asymmetric synthesis and CD investigation of the 1,4-benzodioxane lignans eusiderins A, B, C, G, L, and M.

  The Journal of organic chemistry 20120921

• Synthesis and antihepatotoxic activity of 5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-substituted-phenyl-4,5-dihydro-1H-pyrazole derivatives.

  Bioorganic & medicinal chemistry letters 20111215

• Synthesis, biological evaluation, and molecular docking studies of 1,3,4-oxadiazole derivatives possessing 1,4-benzodioxan moiety as potential anticancer agents.

  Bioorganic & medicinal chemistry 20111101

• Synthesis, biological evaluation and molecular docking studies of 1,3,4-thiadiazole derivatives containing 1,4-benzodioxan as potential antitumor agents.

  Bioorganic & medicinal chemistry letters 20111015

• Synthesis and antitumor activity of 1,2,4-triazoles having 1,4-benzodioxan fragment as a novel class of potent methionine aminopeptidase type II inhibitors.

  Bioorganic & medicinal chemistry 20111015

• Oxadiazole derivatives containing 1,4-benzodioxan as potential immunosuppressive agents against RAW264.7 cells.

  Bioorganic & medicinal chemistry 20110815

• Rotationally resolved electronic spectroscopy of 1,4-benzodioxan: the anomeric effect in the ground and electronically excited state.

  Chemphyschem : a European journal of chemical physics and physical chemistry 20110711

• Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) studies on α(1A)-adrenergic receptor antagonists based on pharmacophore molecular alignment.

  International journal of molecular sciences 20110101

• 7-Phenyl-sulfonyl-2,3-dihydro-7H-1,4-benzodioxino[6,7-b]carbazole.

  Acta crystallographica. Section E, Structure reports online 20101201

• Copper-catalyzed tandem process: an efficient approach to 2-substituted-1,4-benzodioxanes.

  Organic & biomolecular chemistry 20100621

• Synthesis and glycogen phosphorylase inhibitory activity of N-(beta-D-glucopyranosyl)amides possessing 1,4-benzodioxane moiety.

  Bioorganic & medicinal chemistry 20090915

• Synthesis, crystal structure and immunosuppressive activity of acylamide derivatives containing 1,4-benzodioxan.

  ChemMedChem 20090901

• 5-(2-Pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes: synthesis of all the stereoisomers and alpha4beta2 nicotinic affinity.

  Bioorganic & medicinal chemistry letters 20090201

• Structure-activity relationships in 1,4-benzodioxan-related compounds. 9. From 1,4-benzodioxane to 1,4-dioxane ring as a promising template of novel alpha1D-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents.

  Journal of medicinal chemistry 20081023

• Experimental and computational thermochemistry of 1,4-benzodioxan and its 6-R derivatives.

  The journal of physical chemistry. A 20080828

• Cation spectroscopy and binding energy determination for 1,4-benzodioxan-Ar1 and -Ar2 complexes.

  The journal of physical chemistry. A 20080731

• Theoretical calculations and vibrational spectra of 1,4-benzodioxan in its S(1)(pi, pi*) electronic excited state.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071231

• Synthesis and glycogen phosphorylase inhibitor activity of 2,3-dihydrobenzo[1,4]dioxin derivatives.

  Bioorganic & medicinal chemistry 20070615

• A comparative study on absorption and selectivity of organic vapors by using ionic liquids based on imidazolium, quaternary ammonium, and guanidinium cations.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

• Synthesis and alpha4beta2 nicotinic affinity of unichiral 5-(2-pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes.

  Bioorganic & medicinal chemistry letters 20061101

• Laser-induced fluorescence spectra, structure, and the ring-twisting and ring-bending vibrations of 1,4-benzodioxan in its S0 and S1(pi,pi*) states.

  The journal of physical chemistry. A 20060817

• Modulation of selective serotonin reuptake inhibitor and 5-HT1A antagonist activity in 8-aza-bicyclo[3.2.1]octane derivatives of 2,3-dihydro-1,4-benzodioxane.

  Bioorganic & medicinal chemistry letters 20040119

• Structures of 1,4-benzodioxane derivatives from the seeds of Phytolacca americana and their neuritogenic activity in primary cultured rat cortical neurons.

  Chemical & pharmaceutical bulletin 20031201

• A novel series of 2,6,7-substituted 2,3-dihydro-1,4-benzodioxin and 2,6,7-substituted 1,4-benzodioxin derivatives as lipid peroxidation inhibitors. Structure-activity relationships for high inhibition of human low-density lipoprotein peroxidation.

  Journal of medicinal chemistry 20011108

• Total synthesis and antifungal activity of 9-methoxystrobilurin L as the originally proposed 1,4-benzodioxan structure.

  Bioorganic & medicinal chemistry letters 20011022

• Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties.

  Journal of medicinal chemistry 20010412

• Antitumor agents. Synthesis and biological evaluation of new compounds related to podophyllotoxin, containing the 2,3-dihydro-1,4-benzodioxin system.

  European journal of medicinal chemistry 20010401