50-44-2 | 6-Mercaptopurine

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$12.00	$8.00
5g	95%	in stock	$18.00	$12.00
10g	95%	in stock	$30.00	$21.00
25g	95%	in stock	$73.00	$51.00
100g	95%	in stock	$201.00	$141.00
500g	95%	in stock	$572.00	$400.00

Description

• Catalog Number: AB51053
• Chemical Name: 6-Mercaptopurine
• CAS Number: 50-44-2
• Molecular Formula: C5H4N4S
• Molecular Weight: 152.1771
• MDL Number: MFCD03854445
• SMILES: Sc1ncnc2c1[nH]cn2

Computed Properties

• Complexity: 190
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2

Literature

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• A cross-sectional investigation of chronic exposure to microcystin in relationship to childhood liver damage in the Three Gorges Reservoir Region, China.

  Environmental health perspectives 20111001

• Update on the management of ulcerative colitis.

  Current gastroenterology reports 20111001

• Mesenchymal stromal cell function is not affected by drugs used in the treatment of inflammatory bowel disease.

  Cytotherapy 20111001

• Individualized toxicity-titrated 6-mercaptopurine increments during high-dose methotrexate consolidation treatment of lower risk childhood acute lymphoblastic leukaemia. A Nordic Society of Paediatric Haematology and Oncology (NOPHO) pilot study.

  British journal of haematology 20111001

• Thiopurine metabolite measurement - not for everyone.

  Alimentary pharmacology & therapeutics 20111001

• Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells.

  Nature medicine 20111001

• Diagnosis and treatment of fistulising Crohn's disease.

  Danish medical bulletin 20111001

• Splenic littoral cell hemangioendothelioma in a patient with Crohn's disease previously treated with immunomodulators and anti-TNF agents: a rare tumor linked to deep immunosuppression.

  The American journal of gastroenterology 20111001

• Nucleobase transport by human equilibrative nucleoside transporter 1 (hENT1).

  The Journal of biological chemistry 20110916

• Thiopurine immunomodulators in ulcerative colitis: moving forward with current evidence.

  Current drug targets 20110901

• 6-Mercaptopurine transport by equilibrative nucleoside transporters in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBTs.

  Journal of pharmaceutical sciences 20110901

• Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients.

  Alimentary pharmacology & therapeutics 20110901

• 3-Aryl-2-[1H-benzotriazol-1-yl]acrylonitriles: a novel class of potent tubulin inhibitors.

  European journal of medicinal chemistry 20110901

• Risk of malignant lymphoma in patients with inflammatory bowel diseases: a Dutch nationwide study.

  Inflammatory bowel diseases 20110901

• Autoimmune neuromuscular disorders.

  Current neuropharmacology 20110901

• Neuropsychiatric systemic lupus erythematosus.

  Current neuropharmacology 20110901

• Toxicities of immunosuppressive treatment of autoimmune neurologic diseases.

  Current neuropharmacology 20110901

• Food-borne bacteremic illnesses in febrile neutropenic children.

  Hematology reports 20110831

• [Stratification therapy in patients with acute promyelocytic leukemia after a complete remission by all-trans retinoic acid].

  Zhonghua yi xue za zhi 20110830

• ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.

  Journal of the National Cancer Institute 20110817

• Efficient DNA interstrand crosslinking by 6-thioguanine and UVA radiation.

  DNA repair 20110815

• Minimally invasive surface-enhanced Raman scattering detection with depth profiles based on a surface-enhanced Raman scattering-active acupuncture needle.

  Analytical chemistry 20110815

• Common misconceptions about 5-aminosalicylates and thiopurines in inflammatory bowel disease.

  World journal of gastroenterology 20110814

• A cost effectiveness analysis of thiopurine methyltransferase testing for guiding 6-mercaptopurine dosing in children with acute lymphoblastic leukemia.

  Pediatric blood & cancer 20110801

• Varicella zoster meningoradiculitis in Crohn's disease treated with 6-mercaptopurine.

  Inflammatory bowel diseases 20110801

• Steroid dependency and pediatric inflammatory bowel disease in the era of immunomodulators--a population-based study.

  Inflammatory bowel diseases 20110801

• Reversible bone marrow necrosis after all-trans retinoic acid induction therapy for acute promyelocytic leukaemia.

  Pathology 20110801

• 6-Mercaptopurine complexes with silver and gold ions: anti-tuberculosis and anti-cancer activities.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110801

• The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells.

  Biochemical and biophysical research communications 20110722

• Current treatment of ulcerative colitis.

  World journal of gastroenterology 20110721

• A microchip electrophoresis strategy with online labeling and chemiluminescence detection for simultaneous quantification of thiol drugs.

  Journal of pharmaceutical and biomedical analysis 20110715

• Escalating intravenous methotrexate improves event-free survival in children with standard-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group.

  Blood 20110714

• Tacrolimus therapy as an alternative to thiopurines for maintaining remission in patients with refractory ulcerative colitis.

  Journal of clinical gastroenterology 20110701

• Detection of thiopurine methyltransferase activity in lysed red blood cells by means of lab-on-a-chip surface enhanced Raman spectroscopy (LOC-SERS).

  Analytical and bioanalytical chemistry 20110701

• Pre-analytic and analytic sources of variations in thiopurine methyltransferase activity measurement in patients prescribed thiopurine-based drugs: A systematic review.

  Clinical biochemistry 20110701

• Relapse rate following azathioprine withdrawal in maintaining remission for Crohn's disease: a meta-analysis.

  Digestive diseases and sciences 20110701

• 'Tac'kling a difficult problem: using tacrolimus to maintain remission in ulcerative colitis.

  Journal of clinical gastroenterology 20110701

• Inflammatory bowel disease therapy: current state-of-the-art.

  Current opinion in gastroenterology 20110701

• Strength capacity in young patients who are receiving maintenance therapy for acute lymphoblastic leukemia: a case-control study.

  Clinics (Sao Paulo, Brazil) 20110701

• Insight into the 6-thiopurine-mediated termination of the invasive motility of tumor cells derived from inflammatory breast cancer.

  Biochemistry 20110628

• Quantum mechanical/molecular mechanical molecular dynamics and free energy simulations of the thiopurine S-methyltransferase reaction with 6-mercaptopurine.

  The journal of physical chemistry. B 20110623

• Nonmyeloablative, HLA-haploidentical bone marrow transplantation with high dose, post-transplantation cyclophosphamide.

  Pediatric reports 20110622

• Assessment of thiopurine S-methyltransferase activity in patients prescribed thiopurines: a systematic review.

  Annals of internal medicine 20110621

• Successful treatment of relapsed and refractory extramedullary acute promyelocytic leukemia with tamibarotene.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110620

• Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease.

  Inflammatory bowel diseases 20110601

• Optimizing thiopurine therapy in inflammatory bowel disease.

  Inflammatory bowel diseases 20110601

• Thiopurine derivatives containing triazole and steroid: synthesis, antimalarial and antileishmanial activities.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110601

• Eruptive benign melanocytic naevi during immunosuppressive therapy in a Crohn's disease patient.

  Inflammatory bowel diseases 20110601

• Biotransformation of 6-thioguanine in inflammatory bowel disease patients: a comparison of oral and intravenous administration of 6-thioguanine.

  British journal of pharmacology 20110601

• Clinical course of Crohn's disease following treatment of lymphoma.

  Inflammatory bowel diseases 20110601

• Meta-analysis of randomised trials comparing thiopurines in childhood acute lymphoblastic leukaemia.

  Leukemia 20110601

• Severe muscular weakness as an isolated symptom of azathioprine hypersensitivity.

  Inflammatory bowel diseases 20110601

• Effects of methylenetetrahydrofolate reductase gene polymorphisms on toxicities during consolidation therapy in pediatric acute lymphoblastic leukemia in a Chinese population.

  Leukemia & lymphoma 20110601

• Female patients suffering from inflammatory bowel diseases are treated less frequently with immunosuppressive medication and have a higher disease activity: a subgroup analysis of a large multi-centre, prospective, internet-based study.

  Journal of Crohn's & colitis 20110601

• The effects of azathioprine on birth outcomes in women with inflammatory bowel disease (IBD).

  Journal of Crohn's & colitis 20110601

• The 6-MP versus placebo clinical trial in acute leukemia.

  Clinical trials (London, England) 20110601

• Toxicological pathology in the rat placenta.

  Journal of toxicologic pathology 20110601

• Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk.

  PLoS currents 20110515

• AIDA 0493 protocol for newly diagnosed acute promyelocytic leukemia: very long-term results and role of maintenance.

  Blood 20110505

• Outcome following thiopurine use in children with ulcerative colitis: a prospective multicenter registry study.

  The American journal of gastroenterology 20110501

• Risk of nonmelanoma skin cancer in patients with inflammatory bowel disease who use thiopurines is not increased.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20110501

• Conventional medical management of inflammatory bowel disease.

  Gastroenterology 20110501

• Identification of BRAF mutations in eruptive melanocytic nevi: new insights into melanomagenesis?

  Expert review of anticancer therapy 20110501

• Azathioprine and mercaptopurine: lymphoma.

  Prescrire international 20110501

• Bayesian analysis for monotone hazard ratio.

  Lifetime data analysis 20110401

• Difficulties and possibilities with thiopurine therapy in inflammatory bowel disease--proceedings of the first Thiopurine Task Force meeting.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20110401

• Treatment of autoimmune hepatitis: a review of current and evolving therapies.

  Journal of gastroenterology and hepatology 20110401

• 6-Mercaptopurine reverses experimental vasospasm and alleviates the production of endothelins in NO-independent mechanism-a laboratory study.

  Acta neurochirurgica 20110401

• Practice patterns in the use of anti-tumor necrosis factor alpha agents in the management of Crohn's disease: a US national practice survey comparing experts and non-experts.

  Digestive diseases and sciences 20110401

• [Plasmacytoid dendritic cell tumor].

  Actas dermo-sifiliograficas 20110401

• Long-term efficacy and safety of cyclosporine as a rescue therapy in acute, steroid-refractory severe ulcerative colitis: switching to infliximab is more effective than treating with concomitant immunomodulators.

  Journal of clinical gastroenterology 20110401

• Long-term results of AIEOP-8805 protocol for acute B-cell lymphoblastic leukemia of childhood.

  Pediatric blood & cancer 20110401

• Determinants of mercaptopurine toxicity in paediatric acute lymphoblastic leukemia maintenance therapy.

  British journal of clinical pharmacology 20110401

• Efficacy of immunosuppressive therapy for inflammatory bowel disease: a systematic review and meta-analysis.

  The American journal of gastroenterology 20110401

• Pyoderma gangrenosum in inflammatory bowel disease: the experience at Mater Health Services' Adult Hospital 1998-2009.

  Journal of Crohn's & colitis 20110401

• Antibacterial activity and phytochemical study of six medicinal plants used in Benin.

  Pakistan journal of biological sciences : PJBS 20110401

• Excited-state dynamics in 6-thioguanosine from the femtosecond to microsecond time scale.

  The journal of physical chemistry. B 20110331

• Treatment of acute promyelocytic leukaemia in the Jehovah's Witness population.

  Annals of hematology 20110301

• The role of standard-dose cytarabine in children with acute promyelocytic leukemia: a single-center experience.

  Journal of pediatric hematology/oncology 20110301

• 6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1.

  Cancer research 20110301

• Preoperative infliximab is not associated with an increased risk of short-term postoperative complications after restorative proctocolectomy and ileal pouch-anal anastomosis.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20110301

• Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing.

  Clinical pharmacology and therapeutics 20110301

• Increased sensitivity to thiopurines in methylthioadenosine phosphorylase-deleted cancers.

  Molecular cancer therapeutics 20110301

• Severe hypoglycemic seizures in a child receiving 6-mercaptopurine.

  Journal of pediatric hematology/oncology 20110301

• Insulin infusion to treat severe hypertriglyceridemia associated with pegaspargase therapy: a case report.

  Journal of pediatric hematology/oncology 20110301

• Treatment outcome of all-trans retinoic acid/anthracycline combination chemotherapy and the prognostic impact of FLT3/ITD mutation in acute promyelocytic leukemia patients.

  The Korean journal of hematology 20110301

• Promyelocytic sarcoma of the sternum: a case report and review of the literature.

  The Korean journal of hematology 20110301

• Recent advances in the diagnosis and management of childhood acute promyelocytic leukemia.

  Korean journal of pediatrics 20110301

• Cyclosporine is safe and effective in patients with severe ulcerative colitis.

  Journal of clinical gastroenterology 20110201

• Prevention and treatment of postoperative Crohn's disease recurrence: an update for a new decade.

  Current gastroenterology reports 20110201

• Patient profiling for treatment toxicity: potential use of clinical and genomic factors.

  Current oncology reports 20110201

• Pregnancy outcome in patients with inflammatory bowel disease treated with thiopurines: cohort from the CESAME Study.

  Gut 20110201

• Effects of chronic immunosuppression on long-term oncologic outcomes for colorectal cancer patients undergoing surgery.

  Annals of surgery 20110201

• Assessment of non-cirrhotic portal hypertension associated with thiopurine therapy in inflammatory bowel disease.

  Journal of Crohn's & colitis 20110201

• Immunosuppressive therapy in children.

  Journal of the Indian Medical Association 20110201

• Pemphigus autoimmunity: hypotheses and realities.

  Autoimmunity 20110201

• Oral 5-aminosalicylic acid for maintenance of surgically-induced remission in Crohn's disease.

  The Cochrane database of systematic reviews 20110119

• Erythroblastic islands.

  Blood 20110106

• The relationship between fetal growth restriction and small placenta in 6-mercaptopurine exposed rat.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20110101

• Cutaneous lymphoproliferative disorder complicating infectious mononucleosis in an immunosuppressed patient.

  Pediatric dermatology 20110101

• Cytogenetic instability in childhood acute lymphoblastic leukemia survivors.

  Journal of biomedicine & biotechnology 20110101

• Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil.

  Drug metabolism and disposition: the biological fate of chemicals 20110101

• Methotrexate-induced subacute neurotoxicity in a child with acute lymphoblastic leukemia carrying genetic polymorphisms related to folate homeostasis.

  American journal of hematology 20110101

• Infliximab and/or azathioprine in the treatment of Crohn's disease-like complications after IPAA.

  Diseases of the colon and rectum 20110101

• Allopurinol might improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio.

  Journal of gastroenterology and hepatology 20110101

• Crohn's disease: a surgeon's perspective.

  Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 20110101

• Ex vivo activity of cardiac glycosides in acute leukaemia.

  PloS one 20110101

• Azathioprine metabolite measurements are not useful in following treatment of autoimmune hepatitis in Alaska Native and other non-Caucasian people.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20110101

• Managing pregnancy in inflammatory rheumatological diseases.

  Arthritis research & therapy 20110101

• Cdc45 limits replicon usage from a low density of preRCs in mammalian cells.

  PloS one 20110101

• Sex differences in drug disposition.

  Journal of biomedicine & biotechnology 20110101

• Adalimumab - an effective and promising treatment for patients with fistulizing Crohn's disease: a case series.

  Journal of medical case reports 20110101

• [Influence of exogeneous proteins on mutagenic process].

  TSitologiia i genetika 20110101

• Presence of intestinal Mycobacterium avium subspecies paratuberculosis (MAP) DNA is not associated with altered MMP expression in ulcerative colitis.

  BMC gastroenterology 20110101

• Infliximab induces clonal expansion of γδ-T cells in Crohn's disease: a predictor of lymphoma risk?

  PloS one 20110101

• Successful treatment of adult onset Langerhans cell histiocytosis with multi-drug combination therapy.

  Internal medicine (Tokyo, Japan) 20110101

• Clinical relevance of thiopurine S-methyltransferase gene polymorphisms.

  Neoplasma 20110101

• Medication safety of five oral chemotherapies: a proactive risk assessment.

  Journal of oncology practice 20110101

• Safety and efficacy of the immunosuppressive agent 6-tioguanine in murine model of acute and chronic colitis.

  BMC gastroenterology 20110101

• A complicated case of tacrolimus-induced rapid remission after cesarean section in the early third trimester for refractory severe ulcerative colitis flaring in the initial period of gestation.

  Case reports in gastroenterology 20110101

• Current and emerging drugs for the treatment of inflammatory bowel disease.

  Drug design, development and therapy 20110101

• Spontaneous remission of Crohn's disease following a febrile infection: case report and literature review.

  BMC gastroenterology 20110101

• Glucose-6-phosphatase deficiency.

  Orphanet journal of rare diseases 20110101

• 25-hydroxyvitamin D concentration is inversely associated with serum MMP-9 in a cross-sectional study of African American ESRD patients.

  BMC nephrology 20110101

• Disruption of learning processes by chemotherapeutic agents in childhood survivors of acute lymphoblastic leukemia and preclinical models.

  Journal of Cancer 20110101

• A sleeping phantom leg awakened following hemicolectomy, thrombosis, and chemotherapy: a case report.

  Journal of medical case reports 20110101

• Adverse events of thiopurine immunomodulators in patients with inflammatory bowel disease.

  Gastroenterologia y hepatologia 20110101

• An unusual cutaneous manifestation of Crohn's disease.

  Skinmed 20110101

• Predicting selective drug targets in cancer through metabolic networks.

  Molecular systems biology 20110101

• Infliximab therapy for moderately severe Crohn's disease and ulcerative colitis: a retrospective comparison over 6 years.

  Clinical and experimental gastroenterology 20110101

• Amebic encephalitis.

  Surgical neurology international 20110101

• Epidemiology of therapy-related myeloid neoplasms after treatment for pediatric acute lymphoblastic leukemia in the nordic countries.

  Mediterranean journal of hematology and infectious diseases 20110101

• Outcome of combination antiviral therapy in chronic hepatitis C virus infection during therapy of acute lymphoblastic leukemia.

  Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 20110101

• Current and future role of biomarkers in Crohn's disease risk assessment and treatment.

  Clinical and experimental gastroenterology 20110101

• A case of Crohn's disease with improvement after azathioprine-induced pancytopenia.

  Case reports in gastroenterology 20110101

• Clinical therapeutics in pregnancy.

  Journal of biomedicine & biotechnology 20110101

• Rhodococcus equi venous catheter infection: a case report and review of the literature.

  Journal of medical case reports 20110101

• Current and emerging treatments for the management of myasthenia gravis.

  Therapeutics and clinical risk management 20110101

• Acute pancreatitis with saw palmetto use: a case report.

  Journal of medical case reports 20110101

• Mesenchymal stem cells: from experiment to clinic.

  Fibrogenesis & tissue repair 20110101

• Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia.

  Clinical proteomics 20110101

• Drug metabolizing enzyme activities versus genetic variances for drug of clinical pharmacogenomic relevance.

  Clinical proteomics 20110101

• A Burkitt's Lymphoma Case Mimicking Crohn's Disease: A Case Report.

  Case reports in medicine 20110101

• Clostridium difficile Infection and Inflammatory Bowel Disease: A Review.

  Gastroenterology research and practice 20110101

• Vitiligo during Treatment of Crohn's Disease with Adalimumab: Adverse Effect or Co-Occurrence?

  Case reports in dermatology 20110101

• Iridoid glycosides fraction of Folium syringae leaves modulates NF-κB signal pathway and intestinal epithelial cells apoptosis in experimental colitis.

  PloS one 20110101

• Eosinophilic enteritis confined to an ileostomy site.

  Case reports in gastroenterology 20110101

• Oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis.

  Clinical ophthalmology (Auckland, N.Z.) 20110101

• Hypersensitivity reactions to anticancer agents: data mining of the public version of the FDA adverse event reporting system, AERS.

  Journal of experimental & clinical cancer research : CR 20110101

• Diabetes insipidus associated with a thickened pituitary stalk in a case of Langerhans Cell Histiocytosis.

  Journal of pediatric neurosciences 20110101

• Immunomodulators and immunosuppressants for Japanese patients with ulcerative colitis.

  ISRN gastroenterology 20110101

• Role of mucosal inflammation in eosinophilic esophagitis: review of the literature.

  ISRN gastroenterology 20110101

• Drug sensitivity patterns of HHV8 carrying body cavity lymphoma cell lines.

  BMC cancer 20110101

• Infliximab to treat Crohn's disease: an update.

  Clinical and experimental gastroenterology 20110101

• The use, safety, and effectiveness of herpes zoster vaccination in individuals with inflammatory and autoimmune diseases: a longitudinal observational study.

  Arthritis research & therapy 20110101

• A thiopurine drug inhibits West Nile virus production in cell culture, but not in mice.

  PloS one 20110101

• Ulcerative colitis in infancy.

  Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 20110101

• Novel formulation of a methotrexate derivative with a lipid nanoemulsion.

  International journal of nanomedicine 20110101

• Treatment of Acute Promyelocytic Leukemia with AIDA Based Regimen. Update of a Tunisian Single Center Study.

  Mediterranean journal of hematology and infectious diseases 20110101

• 'Il corpo ritrovato': dermocosmetological skin care project for the oncologic patient.

  ISRN oncology 20110101

• The reasons for discontinuation of infliximab treatment in patients with Crohn's disease: a review of practice at NHS teaching hospital.

  ISRN gastroenterology 20110101

• Mechanisms of neurotoxicity induced in the developing brain of mice and rats by DNA-damaging chemicals.

  The Journal of toxicological sciences 20110101

• Azathioprine induced cholestatic hepatitis.

  Indian journal of pharmacology 20110101

• Biologics in paediatric Crohn's disease.

  Gastroenterology research and practice 20110101

• Type 1 autoimmune pancreatitis.

  Orphanet journal of rare diseases 20110101

• Characterization of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin.

  PloS one 20110101

• Thiopurine methyltransferase predicts the extent of cytotoxicty and DNA damage in astroglial cells after thioguanine exposure.

  PloS one 20110101

• Peripheral Blood CD64 Levels Decrease in Crohn's Disease following Granulocyte and Monocyte Adsorptive Apheresis.

  Case reports in gastroenterology 20110101

• Clinical features and treatment outcome of acute promyelocytic leukemia patients treated at cairo national cancer institute in egypt.

  Mediterranean journal of hematology and infectious diseases 20110101

• Emerging role of rasburicase in the management of increased plasma uric acid levels in patients with hematologic malignancies.

  Journal of blood medicine 20110101

• Nevogenesis: a benign metastatic process?

  ISRN dermatology 20110101

• Measures of rheumatoid arthritis disease activity in Australian clinical practice.

  ISRN rheumatology 20110101

• Catheter-Related Acremonium kiliense Fungemia in a Patient with Ulcerative Colitis under Treatment with Infliximab.

  Case reports in infectious diseases 20110101

• Gold nanoparticles in biology and medicine: recent advances and prospects.

  Acta naturae 20110101

• Compliance with a protocol for acute lymphoblastic leukemia in childhood.

  Revista brasileira de hematologia e hemoterapia 20110101

• Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial.

  Lancet (London, England) 20101211

• Frequency of TPMT alleles in Indian patients with acute lymphatic leukemia and effect on the dose of 6-mercaptopurine.

  Medical oncology (Northwood, London, England) 20101201

• Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines.

  The pharmacogenomics journal 20101201

• Combination biological and surgical therapy in an adolescent presenting with highly destructive perianal Crohn disease.

  Journal of pediatric gastroenterology and nutrition 20101201

• A single-center experience with methotrexate after thiopurine therapy in pediatric Crohn disease.

  Journal of pediatric gastroenterology and nutrition 20101201

• A predictive ligand-based Bayesian model for human drug-induced liver injury.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Ecto-5'-nucleotidase and thiopurine cellular circulation: association with cytotoxicity.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Preparing the patient for immunosuppressive therapy.

  Current gastroenterology reports 20101201

• Thiopurines in Crohn's disease, is there something new?

  Expert opinion on drug metabolism & toxicology 20101201

• Infliximab, azathioprine or combination therapy in the treatment of active Crohn's disease.

  Expert review of gastroenterology & hepatology 20101201

• Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease.

  Journal of Crohn's & colitis 20101201

• Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells.

  PLoS computational biology 20101201

• Outcome of childhood acute promyelocytic leukemia treated using a modified AIDA protocol.

  The Korean journal of hematology 20101201

• Cancer pharmacogenomics and pharmacoepidemiology: setting a research agenda to accelerate translation.

  Journal of the National Cancer Institute 20101117

• Thiol with an unusual adsorption-desorption behavior: 6-mercaptopurine on Au(111).

  Langmuir : the ACS journal of surfaces and colloids 20101116

• Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710.

  Blood 20101111

• Azathioprine-induced hypersensitivity hepatitis: tolerance to 6-mercaptopurine.

  Inflammatory bowel diseases 20101101

• The inflammatory bowel diseases and ambient air pollution: a novel association.

  The American journal of gastroenterology 20101101

• Acute pancreatitis in type 2 diabetes treated with exenatide or sitagliptin: a retrospective observational pharmacy claims analysis.

  Diabetes care 20101101

• Activating BRAF mutations in eruptive melanocytic naevi.

  The British journal of dermatology 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Childhood acute lymphoblastic leukemia in Turkey: factors influencing treatment and outcome: a single center experience.

  Journal of pediatric hematology/oncology 20101101

• Allopurinol-thiopurine combination therapy in inflammatory bowel disease: are there genetic clues to this puzzle?

  Pharmacogenomics 20101101

• Hepatosplenic T-cell lymphoma and inflammatory bowel disease.

  Journal of Crohn's & colitis 20101101

• A prospective evaluation of the impact of allopurinol in pediatric and adult IBD patients with preferential metabolism of 6-mercaptopurine to 6-methylmercaptopurine.

  Journal of Crohn's & colitis 20101101

• Adherence of gastroenterologists to European Crohn's and Colitis Organisation consensus on ulcerative colitis: a real-life survey in Spain.

  Journal of Crohn's & colitis 20101101

• Long-term efficacy of adalimumab in paediatric Crohn's disease patients naïve to other anti-TNF therapies.

  Journal of Crohn's & colitis 20101101

• Usefulness of the measurement of azathioprine metabolites in the assessment of non-adherence.

  Journal of Crohn's & colitis 20101101

• [A successful case of tanshinone II A treatment for relapsed acute promyelocytic leukemia after maintainance therapy of all-trans retinoic acid and arsenic trioxide].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20101101

• Brief report: Barriers to treatment adherence in pediatric inflammatory bowel disease.

  Journal of pediatric psychology 20101001

• Merkel cell carcinoma metastatic to the thyroid gland: Aspiration findings and differential diagnosis.

  Diagnostic cytopathology 20101001

• The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease.

  Journal of gastroenterology 20101001

• Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL#3 as adjunctive to a standard pharmaceutical treatment: a double-blind, randomized, placebo-controlled study.

  The American journal of gastroenterology 20101001

• Genetic analysis of thiopurine methyltransferase polymorphism in the Jordanian population.

  European journal of clinical pharmacology 20101001

• Allopurinol salvage therapy in pediatric overlap autoimmune hepatitis-primary sclerosing cholangitis with 6-MMP toxicity.

  Journal of pediatric gastroenterology and nutrition 20101001

• Vaccinations in patients with immune-mediated inflammatory diseases.

  Rheumatology (Oxford, England) 20101001

• Renal cell carcinoma and acute promyelocytic leukemia: a nonrandom association?

  American journal of hematology 20101001

• Combination of the histone deacetylase inhibitor valproic acid with oral hydroxyurea or 6-mercaptopurin can be safe and effective in patients with advanced acute myeloid leukaemia--a report of five cases.

  Hematology (Amsterdam, Netherlands) 20101001

• Monitoring 6-thioguanine nucleotide concentrations in Japanese children and adolescents with inflammatory bowel disease.

  Journal of gastroenterology and hepatology 20101001

• Hepatosplenic T-cell lymphoma in inflammatory bowel disease: a possible thiopurine-induced chromosomal abnormality.

  The American journal of gastroenterology 20101001

• Thiopurine therapy in inflammatory bowel disease.

  Expert review of gastroenterology & hepatology 20101001

• Combination of thiopurines and allopurinol: adverse events and clinical benefit in IBD.

  Journal of Crohn's & colitis 20101001

• Tolerability and usefulness of mercaptopurine in azathioprine-intolerant Japanese patients with ulcerative colitis.

  Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 20101001

• An unusual case of capecitabine hyperpigmentation: Is hyperpigmentation a part of hand-foot syndrome or a separate entity?

  Indian journal of pharmacology 20101001

• Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1.

  Biochemical pharmacology 20100915

• Substrate orientation and catalytic specificity in the action of xanthine oxidase: the sequential hydroxylation of hypoxanthine to uric acid.

  The Journal of biological chemistry 20100903

• Bone marrow suppression in the setting of normal thiopurine methyltransferase phenotype testing.

  Clinical pediatrics 20100901

• Thiopurine pathway.

  Pharmacogenetics and genomics 20100901

• The impact of high-dose methotrexate on intracellular 6-mercaptopurine disposition during interval therapy of childhood acute lymphoblastic leukemia.

  Cancer chemotherapy and pharmacology 20100901

• Treatment-associated acute myeloid leukemia in a patient with Crohn's disease on 6-mercaptopurine.

  Inflammatory bowel diseases 20100901

• Thiopurine therapy in inflammatory bowel disease patients: analyses of two 8-year intercept cohorts.

  Inflammatory bowel diseases 20100901

• Natural history of Crohn's disease in a population-based cohort from Cardiff (1986-2003): a study of changes in medical treatment and surgical resection rates.

  Gut 20100901

• Outcomes of pregnancies fathered by inflammatory bowel disease patients exposed to thiopurines.

  The American journal of gastroenterology 20100901

• [Remission of ulcerative colitis after appendectomy: a case report].

  The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20100901

• Cologastric fistula with a foreign body in a patient with Crohn's disease.

  The Yale journal of biology and medicine 20100901

• Acquired factor VIII deficiency after consuming the dried gallbladder of a cobra, Naja naja.

  The Korean journal of hematology 20100901

• Optimizing therapy with 6-mercaptopurine and azathioprine: to measure or not to measure?

  Therapeutic advances in gastroenterology 20100901

• Change in the treatment strategy for pediatric Crohn's disease.

  Korean journal of pediatrics 20100901

• CNS relapse in acute promyeloctyic leukemia.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100820

• DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma.

  Cancer chemotherapy and pharmacology 20100801

• Thiopurine maintenance therapy for ulcerative colitis: the clinical significance of monitoring 6-thioguanine nucleotide.

  Inflammatory bowel diseases 20100801

• Thiopurine S-methyltransferase gene polymorphism and 6-mercaptopurine dose intensity in Indian children with acute lymphoblastic leukemia.

  Leukemia research 20100801

• Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis.

  Inflammatory bowel diseases 20100801

• Pyridoxine treatment of vincristine-induced cranial polyneuropathy in an adult patient with acute lymphocytic leukemia: Case report and review of the literature.

  Leukemia research 20100801

• Nuclear receptor Nur77 suppresses inflammatory response dependent on COX-2 in macrophages induced by oxLDL.

  Journal of molecular and cellular cardiology 20100801

• 6-mercaptopurine inhibits atherosclerosis in apolipoprotein e*3-leiden transgenic mice through atheroprotective actions on monocytes and macrophages.

  Arteriosclerosis, thrombosis, and vascular biology 20100801

• 6-Mercaptopurine exerts an immunomodulatory and neuroprotective effect on permanent focal cerebral occlusion in rats.

  Acta neurochirurgica 20100801

• Monitoring of azathioprine metabolites in pediatric patients with autoimmune hepatitis.

  Therapeutic drug monitoring 20100801

• Immunosuppressive treatments in Crohn's disease induce myelodysplasia and leukaemia.

  American journal of hematology 20100801

• Randomized trial to compare LSA2L2-type maintenance therapy to daily 6-mercaptopurine and weekly methotrexate with vincristine and dexamethasone pulse for children with acute lymphoblastic leukemia.

  Pediatric blood & cancer 20100801

• Langerhans cell histiocytosis in a child with non-Hodgkin lymphoma.

  Journal of pediatric hematology/oncology 20100801

• 6-Mercaptopurine, monocytes, and atherosclerosis.

  Arteriosclerosis, thrombosis, and vascular biology 20100801

• Complete paraplegia after nelarabine treatment in a T-cell acute lymphoblastic leukemia adult patient.

  American journal of hematology 20100801

• IBD: Switching metabolism-can two drugs be better than one?

  Nature reviews. Gastroenterology & hepatology 20100801

• The genetics of inflammatory bowel disease: diagnostic and therapeutic implications.

  World journal of pediatrics : WJP 20100801

• Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine.

  Chemico-biological interactions 20100730

• Thiopurine S-methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease.

  World journal of gastroenterology 20100707

• Review article: malignancy on thiopurine treatment with special reference to inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20100701

• A 30-month-old child with acute renal failure due to primary renal cytotoxic T-cell lymphoma.

  The American journal of surgical pathology 20100701

• LC-MS/MS coupled with stable isotope dilution method for the quantification of 6-thioguanine and S(6)-methylthioguanine in genomic DNA of human cancer cells treated with 6-thioguanine.

  Analytical chemistry 20100701

• Crystallographic and docking studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry 20100701

• Influence of 5-aminosalicylic acid on 6-thioguanosine phosphate metabolite levels: a prospective study in patients under steady thiopurine therapy.

  British journal of pharmacology 20100701

• Postoperative Crohn's disease: how can we prevent it?

  Expert review of clinical immunology 20100701

• Use of immunomodulators and biologic therapies in children with inflammatory bowel disease.

  Expert review of clinical immunology 20100701

• [A case of hemophagocytic syndrome in an ulcerative colitis patient].

  The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20100701

• Photodynamic therapy for multi-resistant cutaneous Langerhans cell histiocytosis.

  Rare tumors 20100630

• Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease.

  The Cochrane database of systematic reviews 20100616

• Using adaptive model predictive control to customize maintenance therapy chemotherapeutic dosing for childhood acute lymphoblastic leukemia.

  Journal of theoretical biology 20100607

• Response to medical treatment in patients with Crohn's disease: the role of NOD2/CRAD15, disease phenotype, and age of diagnosis.

  Digestive diseases and sciences 20100601

• Health-related quality of life of youth with inflammatory bowel disease: a comparison with published data using the PedsQL 4.0 generic core scales.

  Inflammatory bowel diseases 20100601

• Azathioprine or mercaptopurine-induced acute pancreatitis is not a disease-specific phenomenon.

  Alimentary pharmacology & therapeutics 20100601

• Limited stability of thiopurine metabolites in blood samples: relevant in research and clinical practise.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601

• Central nervous system complications during treatment of acute lymphoblastic leukemia in a single pediatric institution.

  Leukemia & lymphoma 20100601

• Novel strategies in the thiopurine treatment of inflammatory bowel disease.

  Nucleosides, nucleotides & nucleic acids 20100601

• How should thiopurine treatment be monitored?--methodological aspects.

  Nucleosides, nucleotides & nucleic acids 20100601

• Seronegative polyarthritis as severe systemic disease.

  The Netherlands journal of medicine 20100601

• Subcutaneous panniculitis-like T-cell lymphoma in a 19 month-old boy: a case report.

  Collegium antropologicum 20100601

• Localization of the magnetic equivalent of the ERN and induced oscillatory brain activity.

  NeuroImage 20100515

• Impact of concomitant immunomodulator use on long-term outcomes in patients receiving scheduled maintenance infliximab.

  Digestive diseases and sciences 20100501

• Safety of immunomodulators and biologics for the treatment of inflammatory bowel disease during pregnancy and breast-feeding.

  Inflammatory bowel diseases 20100501

• The impact of thiopurines on the risk of surgical recurrence in patients with Crohn's disease after first intestinal surgery.

  The American journal of gastroenterology 20100501

• Reaction mechanisms of allicin and allyl-mixed disulfides with proteins and small thiol molecules.

  European journal of medicinal chemistry 20100501

• Prediction of 6-thioguanine nucleotides levels in Japanese patients with inflammatory bowel diseases during long-term thiopurine administration.

  Scandinavian journal of gastroenterology 20100501

• 6-Mercaptopurine attenuates adhesive molecules in experimental vasospasm.

  Acta neurochirurgica 20100501

• Desensitization of patients with allergic reactions to immunosuppressives in the treatment of inflammatory bowel disease.

  Expert opinion on drug safety 20100501

• Prospective study of hemostatic alterations in children with acute lymphoblastic leukemia.

  American journal of hematology 20100501

• Neurological complications during treatment of childhood cancer: mind Wernicke encephalopathy.

  Pediatric hematology and oncology 20100501

• trans-Tetra-aqua-bis{(E)-2-cyano-1-[(ethoxy-carbon-yl)methyl-sulfan-yl]-2-(1-naphthyl-amino-carbon-yl)ethene-1-thiol-ato}calcium(II) diethyl ether disolvate.

  Acta crystallographica. Section E, Structure reports online 20100501

• Benefits of the intermittent use of 6-mercaptopurine and methotrexate in maintenance treatment for low-risk acute lymphoblastic leukemia in children: randomized trial from the Brazilian Childhood Cooperative Group--protocol ALL-99.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100410

• Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2.

  The Journal of biological chemistry 20100409

• Oral 6-mercaptopurine versus oral 6-thioguanine and veno-occlusive disease in children with standard-risk acute lymphoblastic leukemia: report of the Children's Oncology Group CCG-1952 clinical trial.

  Blood 20100408

• Design and in vitro evaluation of branched peptide conjugates: turning nonspecific cytotoxic drugs into tumor-selective agents.

  ChemMedChem 20100406

• Recent advances in the management of distal ulcerative colitis.

  World journal of gastrointestinal pharmacology and therapeutics 20100406

• Contemporary challenges in mastocytosis.

  Clinical reviews in allergy & immunology 20100401

• Central nervous system involvement at the time of presentation in acute promyelocytic leukemia.

  Pediatric blood & cancer 20100401

• Prospective bone ultrasound patterns during childhood acute lymphoblastic leukemia treatment.

  Bone 20100401

• Ongoing remission after intensive ALL-type chemotherapy in pediatric intestinal T-cell lymphoma.

  Pediatric blood & cancer 20100401

• Supervising the supervisors--procedural training and supervision in internal medicine residency.

  Journal of general internal medicine 20100401

• Pancreatitis in inflammatory bowel diseases.

  Journal of clinical gastroenterology 20100401

• Cytomegalovirus infection in patients with active inflammatory bowel disease.

  Digestive diseases and sciences 20100401

• The degree of myelosuppression during maintenance therapy of adolescents with B-lineage intermediate risk acute lymphoblastic leukemia predicts risk of relapse.

  Leukemia 20100401

• Hepatosplenic T-cell lymphoma in a young man with Crohn's disease: case report and literature review.

  Clinical lymphoma, myeloma & leukemia 20100401

• Disseminated coccidioidomycosis in a patient managed with adalimumab for Crohn's disease.

  Nature reviews. Gastroenterology & hepatology 20100401

• [Tolerability of 6-mercaptopurine in children with acute lymphoblastic leukemia].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20100401

• Very long-term outcome of acute promyelocytic leukemia after treatment with all-trans retinoic acid and chemotherapy: the European APL Group experience.

  Blood 20100304

• Preoperative infliximab treatment in patients with ulcerative and indeterminate colitis does not increase rate of conversion to emergent and multistep abdominal surgery.

  International journal of colorectal disease 20100301

• Azathioprine, mucosal healing in ulcerative colitis, and the chemoprevention of colitic cancer: a clinical-practice-based forecast.

  Inflammation & allergy drug targets 20100301

• Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20100301

• Anticancer agents against malaria: time to revisit?

  Trends in parasitology 20100301

• Outpatient care for inflammatory bowel disease at a primary referral hospital in Turin.

  Minerva gastroenterologica e dietologica 20100301

• Significance of myeloid antigen expression in precursor T lymphoblastic lymphoma.

  Chinese journal of cancer 20100301

• Human lymphoblastoid cell line panels: novel tools for assessing shared drug pathways.

  Pharmacogenomics 20100301

• Juvenile myelomonocytic leukemia with PTPN11 mutation in a 23-month-old girl.

  Collegium antropologicum 20100301

• N,N'-Bis(2-chloroethyl)-N-nitrosourea (BCNU)-induced Apoptosis of Neural Progenitor Cells in the Developing Fetal Rat Brain.

  Journal of toxicologic pathology 20100301

• 13C chemical shift tensors in hypoxanthine and 6-mercaptopurine: effects of substitution, tautomerism, and intermolecular interactions.

  The journal of physical chemistry. A 20100204

• Toxic non-resorptive internal hydrocephalus as a result of haemorrhagic ventriculitis during induction chemotherapy of Bcr-Abl positive acute lymphoblastic leukaemia.

  Annals of hematology 20100201

• Algorithms outperform metabolite tests in predicting response of patients with inflammatory bowel disease to thiopurines.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20100201

• Central variant of posterior reversible encephalopathy syndrome in systemic lupus erythematosus: new associations?

  Lupus 20100201

• Correlation of genotypes for thiopurine methyltransferase and inosine triphosphate pyrophosphatase with long-term clinical outcomes in Korean patients with inflammatory bowel diseases during treatment with thiopurine drugs.

  Journal of human genetics 20100201

• Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia.

  Leukemia 20100201

• Long-term results of the pediatric oncology group studies for childhood acute lymphoblastic leukemia 1984-2001: a report from the children's oncology group.

  Leukemia 20100201

• 'I am older, not elderly,' said the patient with acute myeloid leukemia.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100201

• Building a tiered approach to in vitro predictive toxicity screening: a focus on assays with in vivo relevance.

  Combinatorial chemistry & high throughput screening 20100201

• Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits.

  Diabetes care 20100201

• Are patients with intermediate TPMT activity at increased risk of myelosuppression when taking thiopurine medications?

  Pharmacogenomics 20100201

• Oedema and Crohn's disease.

  The Netherlands journal of medicine 20100201

• Thiopurine S-methyltransferase genotype and the use of thiopurines in paediatric inflammatory bowel disease Greek patients.

  Journal of clinical pharmacy and therapeutics 20100201

• Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter's syndrome.

  Hematology reports 20100126

• Modulating dendritic cells (DC) from immunogenic to tolerogenic responses: a novel mechanism of AZA/6-MP.

  Journal of neuroimmunology 20100125

• Mercaptopurine rescue after azathioprine-induced liver injury in inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20100101

• Flow injection chemiluminescence determination of 6-mercaptopurine based on a new system of potassium permanganate-thioacetamide-sodium hexametaphosphate.

  Luminescence : the journal of biological and chemical luminescence 20100101

• MTHFR and TYMS genotypes influence TPMT activity and its differential modulation in males and females.

  Clinical biochemistry 20100101

• Pro-inflammatory and pro-coagulant properties of 6-thioguanine and 6-mercaptopurine: implications for their potential role in the development of sinusoidal obstruction syndrome.

  Leukemia & lymphoma 20100101

• Characterisation and utility of thiopurine methyltransferase and thiopurine metabolite measurements in autoimmune hepatitis.

  Journal of hepatology 20100101

• Methylene tetrahydrofolate reductase gene polymorphism in Egyptian children with acute lymphoblastic leukemia.

  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20100101

• Cutaneous xanthogranulomas, hepatosplenomegaly, anemia, and thrombocytopenia as presenting signs of juvenile myelomonocytic leukemia.

  American journal of clinical dermatology 20100101

• Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status.

  Expert opinion on drug safety 20100101

• Mercaptopurine-induced fever: hypersensitivity reaction in a patient with acute lymphoblastic leukemia.

  Pharmacotherapy 20100101

• Idarubicin plus behenoyl cytarabine and 6-thioguanine compares favorably with idarubicin plus cytarabine-based regimen for children with previously untreated acute myeloid leukemia: 10-year retrospective, multicenter study in Korea.

  Journal of Korean medical science 20100101

• Recurrence and impact of postoperative prophylaxis in laparoscopically treated primary ileocolic Crohn disease.

  Archives of surgery (Chicago, Ill. : 1960) 20100101

• Clinical profile, treatment, and visual outcome of ampiginous choroiditis.

  Ocular immunology and inflammation 20100101

• [Immunosuppressive therapy update 2010 for ANCA-associated glomerulonephritis and intractable nephrotic syndrome].

  Nihon Jinzo Gakkai shi 20100101

• Management of hyperuricemia in gout: focus on febuxostat.

  Clinical interventions in aging 20100101

• The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease.

  PloS one 20100101

• The effects of thiopurine therapy on health-related quality of life in Inflammatory Bowel Disease patients.

  BMC gastroenterology 20100101

• Pharmacogenetics of thiopurines in inflammatory bowel disease.

  Current pharmaceutical design 20100101

• Influences of thiopurine methyltransferase genotype and activity on thiopurine-induced leukopenia in Korean patients with inflammatory bowel disease: a retrospective cohort study.

  Journal of clinical gastroenterology 20100101

• An ab initio and AIM investigation into the hydration of 2-thioxanthine.

  Chemistry Central journal 20100101

• Biology-driven cancer drug development: back to the future.

  BMC biology 20100101

• Rapid selection and proliferation of CD133+ cells from cancer cell lines: chemotherapeutic implications.

  PloS one 20100101

• Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.

  PloS one 20100101

• The thioamides methimazole and thiourea inhibit growth of M. avium Subspecies paratuberculosis in culture.

  PloS one 20100101

• Photo-oxidation of 6-thioguanine by UVA: the formation of addition products with low molecular weight thiol compounds.

  Photochemistry and photobiology 20100101

• Experimental human cell and tissue models of pemphigus.

  Dermatology research and practice 20100101

• Long-term follow-up with Granulocyte and Monocyte Apheresis re-treatment in patients with chronically active inflammatory bowel disease.

  BMC gastroenterology 20100101

• [Therapeutic drug monitoring of 6-thioguanine nucleotides in paediatric acute lymphoblastic leukaemia: interest and limits].

  Therapie 20100101

• Guilt by association - what is the true risk of malignancy in children treated with etanercept for JIA?

  Pediatric rheumatology online journal 20100101

• Langerhans cell histiocytosis of the petrous bone with sudden sensorineural hearing loss. Case report.

  Neurologia medico-chirurgica 20100101

• Miss to the right: the effect of attentional asymmetries on goal-kicking.

  PloS one 20100101

• Concurrent sternal and pulmonary foci of Langerhans cell histiocytosis.

  Annals of thoracic medicine 20100101

• [Acute lymphoblastic leukaemia in children and adolescents: chance of cure now higher than 80%].

  Nederlands tijdschrift voor geneeskunde 20100101

• FragViz: visualization of fragmented networks.

  BMC bioinformatics 20100101

• State-of-the-art: Immunosuppression and biologic therapy.

  Digestive diseases (Basel, Switzerland) 20100101

• How rapidly should remission be achieved?

  Digestive diseases (Basel, Switzerland) 20100101

• Fistula treatment: The unresolved challenge.

  Digestive diseases (Basel, Switzerland) 20100101

• Predicting enzyme targets for cancer drugs by profiling human metabolic reactions in NCI-60 cell lines.

  BMC bioinformatics 20100101

• Elevated Levels of DNA Strand Breaks Induced by a Base Analog in the Human Cell Line with the P32T ITPA Variant.

  Journal of nucleic acids 20100101

• Hydronephrosis Resulting from Bilateral Ureteral Stenosis: A Late Complication of Polyoma BK Virus Cystitis?

  Journal of transplantation 20100101

• Dent's disease.

  Orphanet journal of rare diseases 20100101

• Esophageal Crohn's disease treated 'topically' with swallowed aerosolized budesonide.

  Case reports in medicine 20100101

• Genetic variations in human glutathione transferase enzymes: significance for pharmacology and toxicology.

  Human genomics and proteomics : HGP 20100101

• [Guideline 'Diagnosis and treatment of inflammatory bowel disease in children'].

  Nederlands tijdschrift voor geneeskunde 20100101

• Drug interaction and pharmacist.

  Journal of young pharmacists : JYP 20100101

• Use of methotrexate in patients with inflammatory bowel diseases.

  Clinical and experimental rheumatology 20100101

• Usefulness of thiopurine methyltransferase and thiopurine metabolite analysis in clinical practice in patients with inflammatory bowel diseases.

  Acta gastro-enterologica Belgica 20100101

• Vaccination and infection prevention in inflammatory bowel disease.

  F1000 medicine reports 20100101

• Immunomodulators for all patients with inflammatory bowel disease?

  Therapeutic advances in gastroenterology 20100101

• Monitoring treatment response of childhood acute lymphocytic leukemia with certain molecular and biochemical markers.

  Journal of biochemical and molecular toxicology 20100101

• Langerhan's cell histiocytosis: A single institutional experience.

  Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology 20100101

• Personalized medicine: FAQs.

  Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology 20100101

• Early Detection of t(8;21) Chromosomal Translocations During Treatment of PML-RARA Positive Acute Promyelocytic Leukemia: A Case Study.

  Clinical Medicine Insights. Oncology 20100101

• Successful long-term use of infliximab in refractory pouchitis in an adolescent.

  Gastroenterology research and practice 20100101

• [A case of the association of acute lymphoblastic lymphoma with active tuberculosis in the child: a Malian case].

  Le Mali medical 20100101

• Stem cell therapeutics: potential in the treatment of inflammatory bowel disease.

  Clinical and experimental gastroenterology 20100101

• Infliximab therapy in pediatric Crohn's disease: a review.

  Clinical and experimental gastroenterology 20100101

• Advances in the management of gout: critical appraisal of febuxostat in the control of hyperuricemia.

  International journal of nephrology and renovascular disease 20100101

• New and improved strategies for the treatment of gout.

  International journal of nephrology and renovascular disease 20100101

• Intracranial Rosai Dorfman Disease: report of three cases and literature review.

  Asian journal of neurosurgery 20100101

• Design and development of hydrogel nanoparticles for mercaptopurine.

  Journal of advanced pharmaceutical technology & research 20100101

• Nanotechnology for early cancer detection.

  Sensors (Basel, Switzerland) 20100101

• Impact of anti-cancer drugs and other determinants on serum protein binding of morphine 6-glucuronide.

  Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20100101

• Microprocessor in controlled transdermal drug delivery of anti-cancer drugs.

  Journal of materials science. Materials in medicine 20091201

• Peripheral neuropathy with infliximab therapy in inflammatory bowel disease.

  Inflammatory bowel diseases 20091201

• A phase II study of Campath-1H in children with relapsed or refractory acute lymphoblastic leukemia: a Children's Oncology Group report.

  Pediatric blood & cancer 20091201

• Captopril and 6-mercaptopurine: whose SH possesses higher antioxidant ability?

  European journal of medicinal chemistry 20091201

• Population pharmacokinetic analysis of infliximab in patients with ulcerative colitis.

  European journal of clinical pharmacology 20091201

• Immunomodulator agent-related lymphoproliferative disorders.

  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20091201

• Immunomodulation does not alter histology in resected Crohn's disease.

  Techniques in coloproctology 20091201

• [Individual and strain differences of aldehyde oxidase in the rat].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20091201

• Secondary osteosarcoma arising after treatment for childhood hematologic malignancies.

  Upsala journal of medical sciences 20091201

• [Significant changes of pharmacotherapy in gastroenterological rehabilitation of Crohn's disease].

  Die Rehabilitation 20091201

• Partition coefficients of some purine derivatives and its application to pharmacokinetics.

  Die Pharmazie 20091201

• Azathioprine induced pneumonitis in a patient with ulcerative colitis.

  Journal of Crohn's & colitis 20091201

• 6-Benzyl-sulfanyl-9H-purine.

  Acta crystallographica. Section E, Structure reports online 20091201

• Outcome and haemato-toxicity of two chemotherapy regimens for childhood non-Hodgkin's lymphoma in a Kenyan hospital.

  East African medical journal 20091201

• Additional chromosomal abnormalities and their prognostic significance in adult Philadelphia-positive acute lymphoblastic leukemia: with or without imatinib in chemotherapy.

  Annals of hematology 20091101

• 2-Arylbenzimidazoles as antiviral and antiproliferative agents--Part 2.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20091101

• Timing of myelosuppression during thiopurine therapy for inflammatory bowel disease: implications for monitoring recommendations.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20091101

• The development of an objective methodology to measure medication adherence to oral thiopurines in paediatric patients with acute lymphoblastic leukaemia--an exploratory study.

  European journal of clinical pharmacology 20091101

• Effects of interactions of antibacterial drugs with each other and with 6-mercaptopurine on in vitro growth of Mycobacterium avium subspecies paratuberculosis.

  The Journal of antimicrobial chemotherapy 20091101

• Therapy of inflammatory bowel diseases in pregnancy and lactation.

  Expert opinion on drug safety 20091101

• Random serum methotrexate determinations for assessing compliance with maintenance therapy for childhood acute lymphoblastic leukemia.

  Leukemia & lymphoma 20091101

• Patent watch. Drug metabolite claims are patentable.

  Nature reviews. Drug discovery 20091101

• Orange juice and hesperetin supplementation to hyperuricemic rats alter oxidative stress markers and xanthine oxidoreductase activity.

  Journal of clinical biochemistry and nutrition 20091101

• The cytotoxic effects of gemtuzumab ozogamicin (mylotarg) in combination with conventional antileukemic agents by isobologram analysis in vitro.

  Anticancer research 20091101

• On therapeutic drug monitoring of thiopurines in inflammatory bowel disease; pharmacology, pharmacogenomics, drug intolerance and clinical relevance.

  Current drug metabolism 20091101

• Prospective study of the effects of concomitant medications on thiopurine metabolism in inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20091015

• Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease.

  The Cochrane database of systematic reviews 20091007

• Severe refractory orofacial Crohn's disease: report of a case.

  Digestive diseases and sciences 20091001

• The race and dose of chemotherapy should be considered for optimizing maintenance therapy for acute promyelocytic leukemia.

  Leukemia research 20091001

• Adverse events associated with common therapy regimens for moderate-to-severe Crohn's disease.

  The American journal of gastroenterology 20091001

• Glyceraldehyde 3-phosphate dehydrogenase depletion induces cell cycle arrest and resistance to antimetabolites in human carcinoma cell lines.

  The Journal of pharmacology and experimental therapeutics 20091001

• Changes in matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinases (TIMP) expression profile in Crohn's disease after immunosuppressive treatment correlate with histological score and calprotectin values.

  International journal of colorectal disease 20091001

• Dose-response relationships of rat fetal skeleton variations: Relevance for risk assessment.

  Environmental research 20091001

• The effect of active hexose correlated compound in modulating cytosine arabinoside-induced hair loss, and 6-mercaptopurine- and methotrexate-induced liver injury in rodents.

  Cancer epidemiology 20091001

• Dexamethasone-based therapy for childhood acute lymphoblastic leukaemia: results of the prospective Dutch Childhood Oncology Group (DCOG) protocol ALL-9 (1997-2004).

  The Lancet. Oncology 20091001

• Inflammatory bowel diseases and management considerations: fertility and pregnancy.

  Current gastroenterology reports 20091001

• New and emerging therapies for inflammatory bowel diseases.

  Journal of gastroenterology and hepatology 20091001

• Efficacy of methotrexate in Crohn's disease and ulcerative colitis patients unresponsive or intolerant to azathioprine /mercaptopurine.

  Alimentary pharmacology & therapeutics 20090915

• Emerging treatments for complex perianal fistula in Crohn's disease.

  World journal of gastroenterology 20090914

• Autoimmune pancreatitis with multiorgan involvement. A case of pericardial involvement.

  JOP : Journal of the pancreas 20090904

• Autologous hematopoietic stem cell transplantation in adult acute lymphoblastic leukemia: still not out of fashion.

  Annals of hematology 20090901

• Inflammatory bowel disease in the setting of autoimmune pancreatitis.

  Inflammatory bowel diseases 20090901

• On the effect of thalidomide on Mycobacterium avium subspecies paratuberculosis in culture.

  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20090901

• The role of transporters in the pharmacokinetics of orally administered drugs.

  Pharmaceutical research 20090901

• Anaplastic large cell lymphoma of the ovary in a pediatric patient.

  Journal of pediatric hematology/oncology 20090901

• Mutagenicity and potential carcinogenicity of thiopurine treatment in patients with inflammatory bowel disease.

  Cancer research 20090901

• Long term efficacy and safety of allopurinol and azathioprine or 6-mercaptopurine in patients with inflammatory bowel disease.

  Journal of Crohn's & colitis 20090901

• Thiopurines, a previously unrecognised cause for fatigue in patients with inflammatory bowel disease.

  Journal of Crohn's & colitis 20090901

• CNS relapse in a low risk acute promyelocytic leukemia patient treated with ATRA-based regimen: is there a role for prophylactic CNS therapy in acute promyelocytic leukemia?

  Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion 20090901

• Synthesis of designed conductive one-dimensional coordination polymers of Ni(II) with 6-mercaptopurine and 6-thioguanine.

  Inorganic chemistry 20090817

• Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia.

  Blood 20090813

• Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Münster protocols.

  Blood 20090813

• Incidence of stress fractures of the femoral shaft in women treated with bisphosphonate.

  Acta orthopaedica 20090807

• Infliximab and other immunomodulating drugs in patients with inflammatory bowel disease and the risk of serious bacterial infections.

  Alimentary pharmacology & therapeutics 20090801

• The impact of risk stratification by early bone-marrow response in childhood lymphoblastic leukaemia: results from the United Kingdom Medical Research Council trial ALL97 and ALL97/99.

  British journal of haematology 20090801

• Azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in Crohn's disease: a meta-analysis.

  The American journal of gastroenterology 20090801

• Phenylethanoid glycosides from Lantana fucata with in vitro anti-inflammatory activity.

  Journal of natural products 20090801

• Overexpression of X-linked inhibitor of apoptosis protein (XIAP) is an independent unfavorable prognostic factor in childhood de novo acute myeloid leukemia.

  Journal of Korean medical science 20090801

• Use of azathioprine and 6MP in postoperative Crohn's: changing natural history or just along for the ride?

  The American journal of gastroenterology 20090801

• Individualization of thiopurine therapy: thiopurine S-methyltransferase and beyond.

  Pharmacogenomics 20090801

• Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.

  Journal of natural products 20090801

• Hydrogen bonding and stacking pi-pi interactions in solid 6-thioguanine and 6-mercaptopurine (antileukemia and antineoplastic drugs) studied by NMR-NQR double resonance spectroscopy and density functional theory.

  The journal of physical chemistry. A 20090730

• Meta-analysis: the efficacy of azathioprine and mercaptopurine in ulcerative colitis.

  Alimentary pharmacology & therapeutics 20090701

• Capillary electrophoresis determination of thiopurine methyl transferase activity in erythrocytes.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090701

• Thiopurine methyltransferase and thiopurine metabolite testing in patients with inflammatory bowel disease who are taking thiopurine drugs.

  Pharmacogenomics 20090701

• [Prophylaxis and treatment of modified BFM-90 regimen for lymphoblastic lymphoma in children and adolescents accompanied with infection].

  Ai zheng = Aizheng = Chinese journal of cancer 20090701

• Reactivation of bovine tuberculosis in patient treated with infliximab, Switzerland.

  Emerging infectious diseases 20090701

• TPMT*26 (208F-->L), a novel mutation detected in a Chinese.

  British journal of clinical pharmacology 20090701

• T cell lymphoproliferative disorders associated with anti-tumor necrosis factor alpha antibody therapy for ulcerative colitis: literature summary.

  Journal of hematopathology 20090701

• Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2.

  Cancer letters 20090628

• Treating childhood acute lymphoblastic leukemia without cranial irradiation.

  The New England journal of medicine 20090625

• Prognostic significance of CD20 expression in adults with de novo precursor B-lineage acute lymphoblastic leukemia.

  Blood 20090618

• S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts.

  Biochemical pharmacology 20090615

• Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study.

  Blood 20090611

• On the malignant potential of thiopurine therapy.

  Blood 20090611

• Therapeutic strategies for the management of ulcerative colitis.

  Inflammatory bowel diseases 20090601

• Effective treatment of advanced-stage childhood lymphoblastic lymphoma without prophylactic cranial irradiation: results of St Jude NHL13 study.

  Leukemia 20090601

• Monitoring of thiopurine metabolites in patients with inflammatory bowel disease-what is actually measured?

  Therapeutic drug monitoring 20090601

• Fatal disseminated cytomegalovirus infection associated with infliximab and 6-mercaptopurine therapy in a child with Crohn disease.

  The Pediatric infectious disease journal 20090601

• Current and future treatments of autoimmune hepatitis.

  Expert review of gastroenterology & hepatology 20090601

• Acquired acute myelogenous leukemia after therapy for acute promyelocytic leukemia with t(15;17): a case report and review of the literature.

  Puerto Rico health sciences journal 20090601

• Serendipity-methotrexate and 6-mercaptopurine for continuation therapy for patients with acute lymphoblastic leukemia: the leukemic stem cell and beyond?

  Journal of pediatric hematology/oncology 20090601

• Oral methotrexate/6-mercaptopurine may be superior to a multidrug LSA2L2 Maintenance therapy for higher risk childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study.

  Journal of pediatric hematology/oncology 20090601

• Management of eosinophilic granuloma occurring in the appendicular skeleton in children.

  Clinics in orthopedic surgery 20090601

• Safe 6-thioguanine therapy of a TPMT deficient Crohn's disease patient by using therapeutic drug monitoring.

  Journal of Crohn's & colitis 20090601

• Influenza vaccinations: should they really be encouraged for IBD patients being treated with immunosuppressives?

  Inflammatory bowel diseases 20090501

• Heterozygosity at the TPMT gene locus, augmented by mutated MTHFR gene, predisposes to 6-MP related toxicities in childhood ALL patients.

  Leukemia 20090501

• Simultaneous analysis of plasma thiols by high-performance liquid chromatography with fluorescence detection using a new probe, 1,3,5,7-tetramethyl-8-phenyl-(4-iodoacetamido)difluoroboradiaza-s-indacene.

  Journal of chromatography. A 20090501

• Methotrexate treatment in pediatric Crohn disease patients intolerant or resistant to purine analogues.

  Journal of pediatric gastroenterology and nutrition 20090501

• Febuxostat: a new treatment for hyperuricaemia in gout.

  Rheumatology (Oxford, England) 20090501

• The presentation of 6-mercaptopurine overdose in ED.

  The American journal of emergency medicine 20090501

• Chemotherapy induced esophageal stricture.

  Pediatric blood & cancer 20090401

• Roles of inner blood-retinal barrier organic anion transporter 3 in the vitreous/retina-to-blood efflux transport of p-aminohippuric acid, benzylpenicillin, and 6-mercaptopurine.

  The Journal of pharmacology and experimental therapeutics 20090401

• Application of new resin gels for measuring mercury by diffusive gradients in a thin-films technique.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20090401

• Inflammatory bowel disease potpourri: a vignette-based discussion.

  Medicine and health, Rhode Island 20090401

• Reproductive issues in inflammatory bowel disease.

  Medicine and health, Rhode Island 20090401

• Hepatosplenic T-cell lymphoma following infliximab therapy for Crohn's disease.

  The Medical journal of Australia 20090316

• Mercaptopurine treatment should be considered in azathioprine intolerant patients with inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20090315

• 6-Thioguanine therapy in Crohn's disease--observational data in Swedish patients.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20090301

• Early preservation of effector functions followed by eventual T cell memory depletion: a model for the delayed onset of the effect of thiopurines.

  Gut 20090301

• Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study.

  Leukemia 20090301

• Efficacy of infliximab in pediatric Crohn's disease: a randomized multicenter open-label trial comparing scheduled to on demand maintenance therapy.

  Inflammatory bowel diseases 20090301

• Distribution of TPMT risk alleles for thiopurine [correction of thioupurine] toxicity in the Israeli population.

  European journal of clinical pharmacology 20090301

• Systematic review: does concurrent therapy with 5-ASA and immunomodulators in inflammatory bowel disease improve outcomes?

  Alimentary pharmacology & therapeutics 20090301

• Time-course changes in neural cell apoptosis in the rat fetal brain from dams treated with 6-mercaptopurine (6-MP).

  Histology and histopathology 20090301

• [Pharmacological and pharmacogenetic study of two immunomodulators: azathioprine and 6-mercaptopurine. Strategies for preventing complications].

  Gastroenterologie clinique et biologique 20090301

• Where are all the Mycobacterium avium subspecies paratuberculosis in patients with Crohn's disease?

  PLoS pathogens 20090301

• Medical therapy of IBD in 2009.

  Medicine and health, Rhode Island 20090301

• 3-Alkylpyridinium alkaloids from the Pacific sponge Haliclona sp.

  Journal of natural products 20090227

• Development and validation of an HPLC method for the rapid and simultaneous determination of 6-mercaptopurine and four of its metabolites in plasma and red blood cells.

  Journal of pharmaceutical and biomedical analysis 20090220

• Pharmacogenetics--tailoring treatment for the outliers.

  The New England journal of medicine 20090219

• Novel derivatives of 6-mercaptopurine: synthesis, characterization and antiproliferative activities of S-allylthio-mercaptopurines.

  European journal of medicinal chemistry 20090201

• Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia.

  Clinical pharmacology and therapeutics 20090201

• Co-prescribing azathiopurine or 6-mercaptopurine and 5-aminosalicylate compounds in ulcerative colitis.

  Inflammatory bowel diseases 20090201

• 6-mercaptopurine as an alternative to azathioprine in azathioprine-induced hepatoxicity.

  Inflammatory bowel diseases 20090201

• The increasing complexity of mercaptopurine pharmacogenomics.

  Clinical pharmacology and therapeutics 20090201

• [Optimising azathioprine treatment: determination of thiopurine methyltransferase activity and thiopurine metabolites].

  Anales de pediatria (Barcelona, Spain : 2003) 20090201

• Normal thiopurine methyltransferase phenotype testing in a Crohn disease patient with azathioprine induced myelosuppression.

  Internal medicine journal 20090201

• A new method for CE-EC determination of mercaptopurine (MP) in a PMMA biochip with on-chip gold nano-electrode ensemble (GNEE) working and decouple electrodes.

  Journal of nanoscience and nanotechnology 20090201

• [Thiopurine S-methyltransferase gene polymorphism in Chilean blood donors].

  Revista medica de Chile 20090201

• [Treatment of Crohn's disease].

  Praxis 20090121

• Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease.

  The Cochrane database of systematic reviews 20090121

• Response to mercaptopurine for refractory autoimmune cytopenias in children.

  Pediatric blood & cancer 20090101

• Foot-drop: an unusual complaint in Henoch-Schönlein purpura.

  Pediatric nephrology (Berlin, Germany) 20090101

• 6-Mercaptopurine: teaching an old drug new tricks.

  Pediatric blood & cancer 20090101

• Langerhans cell histiocytosis in children.

  Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses 20090101

• 6-Mercaptopurine (6-MP) induces cell cycle arrest and apoptosis of neural progenitor cells in the developing fetal rat brain.

  Neurotoxicology and teratology 20090101

• Targeting of cancer energy metabolism.

  Molecular nutrition & food research 20090101

• Poor treatment compliance in children with down syndrome and acute lymphoblastic leukemia.

  Journal of pediatric hematology/oncology 20090101

• Pharmacogenetics and pharmacogenomics of anticancer agents.

  CA: a cancer journal for clinicians 20090101

• Current strategies for the treatment of ulcerative colitis.

  Recent patents on inflammation & allergy drug discovery 20090101

• Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration.

  Arthritis research & therapy 20090101

• Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment.

  Journal of gastroenterology 20090101

• ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature.

  Journal of hematology & oncology 20090101

• Thiopurine methyltransferase gene polymorphisms in Chinese patients with inflammatory bowel disease.

  Digestion 20090101

• 6-mercaptopurine (6-MP) induces p53-mediated apoptosis of neural progenitor cells in the developing fetal rodent brain.

  Neurotoxicology and teratology 20090101

• Interferon beta-1a for the maintenance of remission in patients with Crohn's disease: results of a phase II dose-finding study.

  BMC gastroenterology 20090101

• Monensin causes dose dependent inhibition of Mycobacterium avium subspecies paratuberculosis in radiometric culture.

  Gut pathogens 20090101

• Hypersensitivity reactions to antineoplastic agents: an overview.

  Anti-cancer drugs 20090101

• Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme.

  Antiviral chemistry & chemotherapy 20090101

• Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine.

  Digestion 20090101

• Severe myelosuppression following alopecia shortly after the initiation of 6-mercaptopurine in a patient with Crohn's disease.

  Internal medicine (Tokyo, Japan) 20090101

• Azathioprine favourably influences the course of malaria.

  Malaria journal 20090101

• Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy.

  PloS one 20090101

• Gold nanoparticles induce cytotoxicity in the alveolar type-II cell lines A549 and NCIH441.

  Particle and fibre toxicology 20090101

• Allele frequency of thiopurine methyltransferase and inosine triphosphate pyrophosphatase gene polymorphisms in Korean patients with inflammatory bowel diseases.

  Hepato-gastroenterology 20090101

• Mycobacterium avium subspecies paratuberculosis, Crohn's disease and the Doomsday scenario.

  Gut pathogens 20090101

• Epstein-Barr Virus (EBV) Prevalence and the Risk of Reactivation in Patients with Inflammatory Arthritis Using Anti-TNF Agents and in those who are Biologic Naive.

  The open rheumatology journal 20090101

• Gout. Novel therapies for treatment of gout and hyperuricemia.

  Arthritis research & therapy 20090101

• Management strategies for pulmonary sarcoidosis.

  Therapeutics and clinical risk management 20090101

• Biologic targeting in the treatment of inflammatory bowel diseases.

  Biologics : targets & therapy 20090101

• Genome-wide analysis of small RNA and novel MicroRNA discovery in human acute lymphoblastic leukemia based on extensive sequencing approach.

  PloS one 20090101

• [P-glycoprotein functional activity in peripheral blood lymphocytes in ulcerative colitis].

  Medicina 20090101

• Mild to moderate Crohn's disease: still room for step-up therapies?

  Digestive diseases (Basel, Switzerland) 20090101

• Drug monitoring in inflammatory bowel disease: helpful or dispensable?

  Digestive diseases (Basel, Switzerland) 20090101

• Drugs associated with more suicidal ideations are also associated with more suicide attempts.

  PloS one 20090101

• Detailed analysis of X chromosome inactivation in a 49,XXXXX pentasomy.

  Molecular cytogenetics 20090101

• Medical management of ulcerative colitis.

  Digestive diseases (Basel, Switzerland) 20090101

• The future of inflammatory bowel disease care.

  Reviews in gastroenterological disorders 20090101

• Current trends in the management of ocular symptoms in Adamantiades-Behçet's disease.

  Clinical ophthalmology (Auckland, N.Z.) 20090101

• Simultaneous occurrence of hyperthyroidism and fistulizing Crohn's disease complicated with intra-abdominal fistulas and abscess: a case report and review of the literature.

  Cases journal 20090101

• Recurrent orbital myositis with radiological feature mimicking thyroid eye disease in a patient with Crohn's disease.

  Orbit (Amsterdam, Netherlands) 20090101

• Patient considerations in the management of ulcerative colitis: role of once-daily MMX mesalamine.

  Patient preference and adherence 20090101

• The efficacy of low dose azathioprine/6-mercaptopurine in patients with inflammatory bowel disease.

  Hepato-gastroenterology 20090101

• Vitamin e and N-acetylcysteine as antioxidant adjuvant therapy in children with acute lymphoblastic leukemia.

  Advances in hematology 20090101

• A systematic review of the reporting of Data Monitoring Committees' roles, interim analysis and early termination in pediatric clinical trials.

  BMC pediatrics 20090101

• An evidence-based review of natalizumab therapy in the management of Crohn's disease.

  Therapeutics and clinical risk management 20090101

• TPMT and DPD polymorphisms: Efficient screening method for Indian patients considering taking Thiopurine and 5-FU drugs.

  Disease markers 20090101

• Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals.

  Drug metabolism and pharmacokinetics 20090101

• Mizoribine: a new approach in the treatment of renal disease.

  Clinical & developmental immunology 20090101

• Development of fludarabine formulations in the treatment of chronic lymphocytic leukemia.

  Drug design, development and therapy 20090101

• Changing therapy from Glivecto a 'copy' imatinib results in a worsening of chronic myeloid leukemia disease status: two case reports.

  Cases journal 20090101

• Hand-foot syndrome due to capecitabine.

  Indian journal of dermatology 20090101

• Molecular dynamics simulation of a human thiopurine S-methyltransferase complexed with 6-mercaptopurine model.

  Bioinformation 20090101

• The rise of an opportunistic infection called 'Invasive Zygomycosis'.

  Journal of global infectious diseases 20090101

• Clinician adoption of genetic testing for drug metabolizing enzymes: is patient safety the low-hanging fruit of personalized medicine?

  AMIA ... Annual Symposium proceedings. AMIA Symposium 20090101

• [Phytocorrection of structural changes in the gastrointestinal tract caused by 6-mercaptopurine].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101

• Polyelectrolyte Complexes: A Review of their Applicability in Drug Delivery Technology.

  Indian journal of pharmaceutical sciences 20090101

• Does infliximab increase complications after surgery for inflammatory bowel disease?

  F1000 medicine reports 20090101

• Extraction of Conditional Probabilities of the Relationships Between Drugs, Diseases, and Genes from PubMed Guided by Relationships in PharmGKB.

  Summit on translational bioinformatics 20090101

• Cause for controversy? Infliximab in the treatment of ulcerative colitis: an update.

  Clinical and experimental gastroenterology 20090101

• Pharmacogenetics: implementing personalized medicine.

  Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases 20090101

• Initial clinical experience with allopurinol-thiopurine combination therapy in pediatric inflammatory bowel disease.

  Inflammatory bowel diseases 20081201

• Minimal residual disease is an important predictive factor of outcome in children with relapsed 'high-risk' acute lymphoblastic leukemia.

  Leukemia 20081201

• Cost-effectiveness of 5-aminosalicylic acid therapy for maintenance of remission in ulcerative colitis.

  The American journal of gastroenterology 20081201

• Population pharmacokinetic and pharmacogenetic analysis of 6-mercaptopurine in paediatric patients with acute lymphoblastic leukaemia.

  British journal of clinical pharmacology 20081201

• Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides.

  European journal of gastroenterology & hepatology 20081201

• Optimizing conventional therapy for inflammatory bowel disease.

  Current gastroenterology reports 20081201

• Thiopurine S-methyltransferase (TPMT) gene polymorphism in Brazilian children with acute lymphoblastic leukemia: association with clinical and laboratory data.

  Therapeutic drug monitoring 20081201

• Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways.

  PLoS medicine 20081201

• [Efficacy of premedication with intravenous corticosteroids and antihistaminics in preventing infusion reactions to infliximab].

  Gastroenterologia y hepatologia 20081201

• [Inflammatory bowel disease. If a patient with Crohn's disease remains in remission for 4 years with azathioprine (or mercaptopurine), should the drug be withdrawn?].

  Gastroenterologia y hepatologia 20081201

• Adalimumab for the treatment of Crohn's disease.

  Biologics : targets & therapy 20081201

• Lower doses of 6-mercaptopurine/azathioprine bring enough clinical efficacy and therapeutic concentration of erythrocyte 6-mercaptopurine metabolite in Japanese IBD patients.

  Journal of Crohn's & colitis 20081201

• Azathioprine treatment during lactation.

  Alimentary pharmacology & therapeutics 20081115

• Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia.

  Blood 20081115

• Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

  Journal of medicinal chemistry 20081113

• A lecithinized superoxide dismutase (PC-SOD) improves ulcerative colitis.

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20081101

• Influence of methylene tetrahydrofolate reductase polymorphisms and coadministration of antimetabolites on toxicity after high dose methotrexate.

  European journal of haematology 20081101

• Oral mucositis in acute lymphoblastic leukaemia: analysis of 169 paediatric patients.

  Oral diseases 20081101

• Maintenance therapy with dose-adjusted 6-mercaptopurine in idiopathic pulmonary hemosiderosis.

  Pediatric pulmonology 20081101

• Pharmacodynamic parameters of immunosuppressive drugs are not correlated with age, duration of dialysis, percentage of lymphocytes or lymphocyte stimulation index in renal transplant recipients.

  Biological & pharmaceutical bulletin 20081101

• 2-Arylbenzimidazoles as antiviral and antiproliferative agents. Part 1.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20081101

• Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.

  PLoS genetics 20081101

• PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients.

  British journal of cancer 20081021

• The effect of thiopurine drugs on DNA methylation in relation to TPMT expression.

  Biochemical pharmacology 20081015

• Results of the hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone regimen in elderly patients with acute lymphocytic leukemia.

  Cancer 20081015

• Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine.

  British journal of clinical pharmacology 20081001

• Laboratory evaluation of inflammatory bowel disease.

  Current opinion in pediatrics 20081001

• What are the rules when treatment with 6-MP/AZA is started?

  Inflammatory bowel diseases 20081001

• Is it always therapeutically important to distinguish between Crohn's disease and ulcerative colitis?

  Inflammatory bowel diseases 20081001

• Neo-clinicians, clinical trials, and the reorganization of medical research in Paris hospitals after the Second World War: the trajectory of Jean Bernard.

  Medical history 20081001

• Treatment of Crohn's disease with colony-stimulating factors: An overview.

  Therapeutics and clinical risk management 20081001

• Complete regression of cirrhosis after immunosuppressive treatment in autoimmune hepatitis.

  Pediatrics international : official journal of the Japan Pediatric Society 20081001

• Miscellaneous.

  Indian journal of pharmacology 20081001

• Crohnology: a tale of time and times and inflammatory bowel diseases.

  World journal of gastroenterology 20080928

• Are we giving azathioprine too late? The case for early immunomodulation in inflammatory bowel disease.

  World journal of gastroenterology 20080928

• Review article: treatment algorithms to maximize remission and minimize corticosteroid dependence in patients with inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20080915

• Influence of xanthine oxidase on thiopurine metabolism in Crohn's disease.

  Alimentary pharmacology & therapeutics 20080915

• Long-term outcome of using allopurinol co-therapy as a strategy for overcoming thiopurine hepatotoxicity in treating inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20080915

• Medication adherence and quality of life in pediatric inflammatory bowel disease.

  Journal of pediatric psychology 20080901

• Efficacy of infliximab for induction and maintenance of remission in intestinal Behçet's disease.

  Inflammatory bowel diseases 20080901

• Predictive factors associated with immunosuppressive agent use in ulcerative colitis: a case-control study.

  Alimentary pharmacology & therapeutics 20080901

• Monitoring 6-thioguanine nucleotide concentrations in Japanese patients with inflammatory bowel disease.

  Journal of gastroenterology and hepatology 20080901

• Thiopurine hepatotoxicity in inflammatory bowel disease: the role for adding allopurinol.

  Expert opinion on drug safety 20080901

• Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides.

  Molecular cancer therapeutics 20080901

• [Benefits and risks of immunosuppression in chronic inflammatory bowel diseases].

  Deutsche medizinische Wochenschrift (1946) 20080901

• Azathioprine: when less is more.

  Journal of gastroenterology and hepatology 20080901

• Gene polymorphisms and pharmacogenetics in rheumatoid arthritis.

  Current genomics 20080901

• Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells.

  Biologics : targets & therapy 20080901

• Infliximab in ulcerative colitis.

  Biologics : targets & therapy 20080901

• Mutagenic and cytotoxic properties of 6-thioguanine, S6-methylthioguanine, and guanine-S6-sulfonic acid.

  The Journal of biological chemistry 20080829

• The study of oxidization fluorescence sensor with molecular imprinting polymer and its application for 6-mercaptopurine (6-MP) determination.

  Talanta 20080815

• On the rate and extent of drug delivery to the brain.

  Pharmaceutical research 20080801

• Clinical pharmacology and pharmacogenetics of thiopurines.

  European journal of clinical pharmacology 20080801

• Pure motor lumbosacral radiculopathy after intrathecal chemotherapy.

  European journal of neurology 20080801

• A video game improves behavioral outcomes in adolescents and young adults with cancer: a randomized trial.

  Pediatrics 20080801

• Palmar-plantar erythrodysesthesia caused by mercaptopurine and mesalamine.

  Archives of dermatology 20080801

• Immune reconstitution during maintenance therapy in children with acute lymphoblastic leukemia, relation to co-existing infection.

  Hematology (Amsterdam, Netherlands) 20080801

• Efficacy of 6-mercaptopurine treatment after azathioprine hypersensitivity in inflammatory bowel disease.

  World journal of gastroenterology 20080721

• Renal cell carcinoma in a patient with cystinosis and inflammatory bowel disease: a case report.

  Pediatric nephrology (Berlin, Germany) 20080701

• Decrease in factor V activity: a new adverse effect of purine analogs in inflammatory bowel diseases?

  Inflammatory bowel diseases 20080701

• Effect of early immunomodulator use in moderate to severe pediatric Crohn disease.

  Inflammatory bowel diseases 20080701

• The role of maintenance chemotherapy after autotransplantation for acute lymphoblastic leukemia in first remission: single-center experience of 100 patients.

  Bone marrow transplantation 20080701

• Azathioprine-induced warfarin resistance.

  The Annals of pharmacotherapy 20080701

• Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review.

  The American journal of gastroenterology 20080701

• Transporter-mediated protection against thiopurine-induced hematopoietic toxicity.

  Cancer research 20080701

• Effects and treatment of inflammatory bowel disease during pregnancy.

  Canadian family physician Medecin de famille canadien 20080701

• Severe neurotoxicities in a case of Charcot-Marie-Tooth disease type 2 caused by vincristine for acute lymphoblastic leukemia.

  Journal of pediatric hematology/oncology 20080701

• Use of allopurinol to optimize thiopurine immunomodulator efficacy in inflammatory bowel disease.

  Gastroenterology & hepatology 20080701

• Down-regulation of Na+/H+ exchanger regulatory factor 1 increases expression and function of multidrug resistance protein 4.

  Cancer research 20080615

• Structural basis of substrate recognition in thiopurine s-methyltransferase.

  Biochemistry 20080610

• Exposing the weaknesses: a systematic review of azathioprine efficacy in ulcerative colitis.

  Digestive diseases and sciences 20080601

• Increased dosing requirements for 6-mercaptopurine and azathioprine in inflammatory bowel disease patients six years and younger.

  Inflammatory bowel diseases 20080601

• Use of methotrexate in refractory Crohn's disease: the Edinburgh experience.

  Inflammatory bowel diseases 20080601

• Thiopurine methyltransferase activity combined with 6-thioguanine metabolite levels predicts clinical response to thiopurines in patients with inflammatory bowel disease.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20080601

• A purine-selective nucleobase/nucleoside transporter in PK15NTD cells.

  American journal of physiology. Regulatory, integrative and comparative physiology 20080601

• Withdrawal of immunosuppression in Crohn's disease treated with scheduled infliximab maintenance: a randomized trial.

  Gastroenterology 20080601

• Antiproliferative oleanane saponins from Meryta denhamii.

  Journal of natural products 20080601

• Modulatory effects of 6-carboxymethylthiopurine on activated murine macrophages.

  Chemical biology & drug design 20080601

• Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20080601

• Fatal myelotoxicity after azathioprine treatment.

  Nucleosides, nucleotides & nucleic acids 20080601

• Effect of 6-mercaptopurine on rat placenta.

  The Journal of veterinary medical science 20080601

• Natalizumab in the treatment of Crohn's disease.

  Biologics : targets & therapy 20080601

• Cytotoxic activities of nucleoside and nucleobase analog drugs in malignant mesothelioma: characterization of a novel nucleobase transport activity.

  Biochemical pharmacology 20080515

• A novel gene delivery system for stable transfection of thiopurine-S-methyltransferase gene in versatile cell types.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080501

• Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine.

  Leukemia research 20080501

• 6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4.

  Human mutation 20080501

• Infliximab-induced disseminated histoplasmosis in a patient with Crohn's disease.

  Nature clinical practice. Gastroenterology & hepatology 20080501

• [Effectiveness of maintenance azathioprine therapy without oral cyclosporine after severe attacks of ulcerative colitis refractory to endovenous steroids].

  Gastroenterologia y hepatologia 20080501

• Influence of MTHFR and RFC1 polymorphisms on toxicities during maintenance chemotherapy for childhood acute lymphoblastic leukemia or lymphoma.

  Journal of pediatric hematology/oncology 20080501

• [Immunomodulator therapy for maintenance of remission in Crohn's disease].

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20080501

• Successful treatment of adult multisystemic Langerhans cell histiocytosis with psoralen-UV-A, prednisolone, mercaptopurine, and vinblastine.

  Archives of dermatology 20080501

• [The frequency and the course of the adverse effects of azathioprine/6-mercaptopurine treatment in patients with inflammatory bowel disease].

  The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20080501

• [The frequency and the course of the adverse effects of azathioprine/6-mercaptopurine treatment in patients with inflammatory bowel disease].

  The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20080501

• [Chemiluminescence determination of 6-mercaptopurine in the luminol-potassium ferricyanide system].

  Guang pu xue yu guang pu fen xi = Guang pu 20080501

• Glutathione transferase activity with a novel substrate mimics the activation of the prodrug azathioprine.

  Analytical biochemistry 20080415

• Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus.

  Biochemical pharmacology 20080415

• [Epstein-Barr virus-associated large B-cell lymphoma in a patient with colitis ulcerosa treated with azathioprine].

  Ugeskrift for laeger 20080407

• How are Azathioprine and 6-mercaptopurine dosed by gastroenterologists? Results of a survey of clinical practice.

  Inflammatory bowel diseases 20080401

• IgA nephropathy associated with leukemia and lymphoma: report of two cases.

  Clinical and experimental nephrology 20080401

• Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes.

  Toxicology in vitro : an international journal published in association with BIBRA 20080401

• A case of adult Langerhans cell histiocytosis showing successfully regenerated osseous tissue of the skull after chemotherapy.

  International journal of hematology 20080401

• Effect of frequently used chemotherapeutic drugs on cytotoxic activity of human cytotoxic T-lymphocytes.

  Journal of immunotherapy (Hagerstown, Md. : 1997) 20080401

• In vivo immunomodulatory, cumulative skin irritation, sensitization and effect of d-limonene on permeation of 6-mercaptopurine through transdermal drug delivery.

  Biological & pharmaceutical bulletin 20080401

• In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile.

  PLoS medicine 20080401

• Acute diarrhea during azathioprine treatment of type I autoimmune hepatitis.

  Minerva medica 20080401

• Outcomes of a modified CALGB 19802 regimen in adult acute lymphoblastic leukemia.

  Journal of Korean medical science 20080401

• Treating refractory leukemias in childhood, role of clofarabine.

  Therapeutics and clinical risk management 20080401

• Parotid acinar cell carcinoma in a long-term survivor of childhood acute lymphoblastic leukemia.

  Pediatric blood & cancer 20080301

• Thyroid involvement with Langerhans cell histiocytosis in a 3-year-old male.

  Pediatric blood & cancer 20080301

• EBV+ lymphoproliferative disease following prolonged chemotherapy for refractory LCH.

  Pediatric blood & cancer 20080301

• Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia.

  Pediatric blood & cancer 20080301

• Triple intrathecal therapy without cranial irradiation for central nervous system preventive therapy in childhood acute lymphoblastic leukemia.

  Pediatric blood & cancer 20080301

• Squamous dysplasia of the rectum in a patient with ulcerative colitis treated with 6-mercaptopurine.

  Digestive diseases and sciences 20080301

• Improved outcome in multisystem Langerhans cell histiocytosis is associated with therapy intensification.

  Blood 20080301

• Effect of buffer and antioxidant on stability of a mercaptopurine suspension.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080301

• Ethnic variation of thiopurine S-methyltransferase activity: a large, prospective population study.

  Pharmacogenomics 20080301

• Rituximab therapy for refractory biliary strictures in immunoglobulin G4-associated cholangitis.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20080301

• The impact of medical therapy for inflammatory bowel disease on pregnancy outcome.

  The American journal of gastroenterology 20080301

• Tubulointerstitial nephritis: an extraintestinal manifestation of Crohn disease in children.

  Journal of pediatric gastroenterology and nutrition 20080301

• Pitfalls, prevention, and treatment of hyperuricemia during tumor lysis syndrome in the era of rasburicase (recombinant urate oxidase).

  Biologics : targets & therapy 20080301

• The Role of heat shock protein 27 in extravillous trophoblast differentiation.

  Journal of cellular biochemistry 20080215

• Treatment of neurodegenerative CNS disease in Langerhans cell histiocytosis with a combination of intravenous immunoglobulin and chemotherapy.

  Pediatric blood & cancer 20080201

• Tolerability and safety of mercaptopurine in azathioprine-intolerant patients with inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20080201

• Absence of nodular regenerative hyperplasia after low-dose 6-thioguanine maintenance therapy in inflammatory bowel disease patients.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20080201

• Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members.

  Journal of molecular biology 20080201

• Synthesis and cytotoxic activity of imidazo[1,2-a]-1,3,5-triazine analogues of 6-mercaptopurine.

  Archiv der Pharmazie 20080201

• Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.

  European journal of clinical pharmacology 20080201

• Use of allopurinol with low-dose 6-mercaptopurine in inflammatory bowel disease to achieve optimal active metabolite levels: a review of four cases and the literature.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20080201

• Isolated central nervous system relapse in childhood acute promyelocytic leukemia.

  Journal of pediatric hematology/oncology 20080201

• Start low, go slow, but don't go this way yet.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20080201

• Azathioprine in inflammatory bowel disease: improved molecular insights and resulting clinical implications.

  Expert review of gastroenterology & hepatology 20080201

• Treatment of inflammatory bowel disease: a review of medical therapy.

  World journal of gastroenterology 20080121

• Gold nanoparticles enhance the anti-leukemia action of a 6-mercaptopurine chemotherapeutic agent.

  Langmuir : the ACS journal of surfaces and colloids 20080115

• Long-term results of the AIEOP-ALL-95 Trial for Childhood Acute Lymphoblastic Leukemia: insight on the prognostic value of DNA index in the framework of Berlin-Frankfurt-Muenster based chemotherapy.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080110

• IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations.

  British journal of clinical pharmacology 20080101

• Azathioprine-associated acute myeloid leukemia in a patient with Crohn's disease and thiopurine S-methyltransferase deficiency.

  American journal of hematology 20080101

• High mobility group protein B1 is an activator of apoptotic response to antimetabolite drugs.

  Molecular pharmacology 20080101

• Health care and cost of medication for inflammatory bowel disease in the Rhein-Main region, Germany: a multicenter, prospective, internet-based study.

  Inflammatory bowel diseases 20080101

• Disparities in the use of immunomodulators and biologics for the treatment of inflammatory bowel disease: a retrospective cohort study.

  Inflammatory bowel diseases 20080101

• Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer.

  Nature reviews. Cancer 20080101

• Stability of thiopurine metabolites: a potential analytical bias.

  Clinical chemistry 20080101

• Ondansetron-associated hypokalemia in a 2-year-old with pre-B-cell ALL.

  Journal of pediatric hematology/oncology 20080101

• Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells.

  Molecular cancer 20080101

• Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: a multi-centre, double-masked, factorial randomised controlled trial.

  Trials 20080101

• Wound healing in patients with cancer.

  Eplasty 20080101

• Pulmonary manifestations in a pediatric patient with ulcerative colitis: a case report.

  Journal of medical case reports 20080101

• Pharmacogenomics of drug-metabolizing enzymes and drug transporters in chemotherapy.

  Methods in molecular biology (Clifton, N.J.) 20080101

• Pharmacogenomics in gastrointestinal disorders.

  Methods in molecular biology (Clifton, N.J.) 20080101

• Histopathology of liver biopsies from a thiopurine-naïve inflammatory bowel disease cohort: prevalence of nodular regenerative hyperplasia.

  Scandinavian journal of gastroenterology 20080101

• Proteomic changes in rat hippocampus and adrenals following short-term sleep deprivation.

  Proteome science 20080101

• The binding of the sulfur and oxygen purine derivatives with bovine serum albumin.

  Acta poloniae pharmaceutica 20080101

• The usefulness of growth hormone treatment for psychological status in young adult survivors of childhood leukaemia: an open-label study.

  BMC pediatrics 20080101

• On the action of cyclosporine A, rapamycin and tacrolimus on M. avium including subspecies paratuberculosis.

  PloS one 20080101

• Efficacy and safety of azathioprine and 6-mercaptopurine in Japanese pediatric patients with ulcerative colitis: a survey of the Japanese Society for Pediatric Inflammatory Bowel Disease.

  Digestion 20080101

• Reactivation of hepatitis B in a patient with Crohn's disease treated using infliximab.

  Journal of gastroenterology 20080101

• Improved outcome for children with acute lymphoblastic leukemia after risk-adjusted intensive therapy: a single-institution experience.

  Annals of Saudi medicine 20080101

• On the prevalence of M. avium subspecies paratuberculosis DNA in the blood of healthy individuals and patients with inflammatory bowel disease.

  PloS one 20080101

• Membranous glomerulopathy associated with rheumatoid arthritis may respond to rituximab.

  Scandinavian journal of rheumatology 20080101

• Sinusoidal obstruction syndrome (veno-occlusive disease) in a patient receiving bevacizumab for metastatic colorectal cancer: a case report.

  Journal of medical case reports 20080101

• Prognostic impact of combined fludarabine, treosulfan and mitoxantrone resistance profile in childhood acute myeloid leukemia.

  Anticancer research 20080101

• Cell killing and resistance in pre-operative breast cancer chemotherapy.

  BMC cancer 20080101

• Laparoscopic ileocolic resection versus infliximab treatment of distal ileitis in Crohn's disease: a randomized multicenter trial (LIR!C-trial).

  BMC surgery 20080101

• [6-mercaptopurine-related hand-foot syndrome in a four-year-old child].

  Annales de dermatologie et de venereologie 20080101

• Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus.

  Arthritis research & therapy 20080101

• Combining gene expression, demographic and clinical data in modeling disease: a case study of bipolar disorder and schizophrenia.

  BMC genomics 20080101

• Effect of dexamethasone on quality of life in children with acute lymphoblastic leukaemia: a prospective observational study.

  Health and quality of life outcomes 20080101

• Undue reliance on I(2) in assessing heterogeneity may mislead.

  BMC medical research methodology 20080101

• Treatment of acute lymphoblastic leukemia in children and adolescents: peaks and pitfalls.

  Hematology. American Society of Hematology. Education Program 20080101

• [Adolescents with de novo acute lymphoblastic leukemia: efficacy and safety of a pediatric vs adult treatment protocol].

  Gaceta medica de Mexico 20080101

• Eosinophilic oesophagitis: clinical manifestations and treatment options. The role of the allergologist.

  Allergologia et immunopathologia 20080101

• [Importance of genotyping of thiopurine S-methyltransferase in children with acute lymphoblastic leukaemia during maintenance therapy].

  Srpski arhiv za celokupno lekarstvo 20080101

• Effects of 5-fluorouracil on human mitogen-activated peripheral blood lymphocytes from healthy individuals.

  Anticancer research 20080101

• Sensitive mercury speciation by reversed-phase column high-performance liquid chromatography with UV-visible detection after solid-phase extraction using 6-mercaptopurine and dithizone.

  Journal of AOAC International 20080101

• New and emerging trends in the treatment of atopic dermatitis.

  Patient preference and adherence 20080101

• Hand-foot syndrome due to capecitabine.

  Indian journal of dermatology 20080101

• Adverse Drug Reactions (ADR) in the inPatients of Medicine Department of a Rural Tertiary Care Teaching Hospital and Influence of Pharmacovigilance in Reporting ADR.

  Indian journal of pharmacology 20080101

• Outcome after relapse among children with standard-risk acute lymphoblastic leukemia: Children's Oncology Group study CCG-1952.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20071220

• Raman spectroscopy of natural accumulated paraffins from rocks: evenkite, ozokerite and hatchetine.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071215

• [Azathioprine and 6-mercaptopurine for maintenance treatment in ulcerative colitis. A survey of a Cochrane review].

  Ugeskrift for laeger 20071210

• The importance of disease associations and concomitant therapy for the long-term management of psoriasis patients.

  Archives of dermatological research 20071201

• Two cases of isolated symptomatic myocarditis induced by all-trans retinoic acid (ATRA).

  Annals of hematology 20071201

• A simple method for the preparation of PEG-6-mercaptopurine for oral administration.

  Bioorganic & medicinal chemistry letters 20071201

• Effect of chronic azathioprine treatment on germ-line transmission of Hprt mutation in mice.

  Environmental and molecular mutagenesis 20071201

• Should TPMT genotype and activity be used to monitor 6-mercaptopurine treatment in children with acute lymphoblastic leukaemia?

  Journal of clinical pharmacy and therapeutics 20071201

• Methotrexate following unsuccessful thiopurine therapy in pediatric Crohn's disease.

  The American journal of gastroenterology 20071201

• The role of xanthine oxidase in thiopurine metabolism: a case report.

  Therapeutic drug monitoring 20071201

• Drug Insight: pharmacology and toxicity of thiopurine therapy in patients with IBD.

  Nature clinical practice. Gastroenterology & hepatology 20071201

• Interaction between mercaptopurine and milk.

  Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20071201

• Successful treatment of steroid refractory active ulcerative colitis with natural interferon-beta--an open long-term trial.

  Zeitschrift fur Gastroenterologie 20071201

• Optimizing drug therapy in inflammatory bowel disease.

  Current gastroenterology reports 20071201

• Dexamethasone in the maintenance phase of acute lymphoblastic leukaemia treatment: is the risk of lethal infections too high?

  European journal of cancer (Oxford, England : 1990) 20071101

• Hepatotoxicity of 6-mercaptopurine (6-MP) and Azathioprine (AZA) in adult IBD patients.

  The American journal of gastroenterology 20071101

• [Optimization of immunomodulatory treatment with azathioprine or 6-mercaptopurine in inflammatory bowel disease].

  Gastroenterologia y hepatologia 20071101

• Ulcerative colitis: diagnosis and treatment.

  American family physician 20071101

• [Current status of treatment of inflammatory bowel disease].

  Cirugia espanola 20071101

• [Pharmacogenomics of acute lymphoblastic leukemia].

  Medecine sciences : M/S 20071101

• [A short duration treatment with intensive consolidation therapy for patients with acute myelogenous leukemia--13 year experience in a single institute].

  Gan to kagaku ryoho. Cancer & chemotherapy 20071101

• [Prediction of adverse drug reactions based on genomic information].

  Nihon rinsho. Japanese journal of clinical medicine 20071028

• [Ulcerative colitis].

  Nihon rinsho. Japanese journal of clinical medicine 20071028

• Influence of the solution pH in the 6-mercaptopurine self-assembled monolayer (6MP-SAM) on a Au(111) single-crystal electrode.

  Langmuir : the ACS journal of surfaces and colloids 20071023

• Chemoprophylaxis of colorectal cancer in inflammatory bowel disease: current concepts.

  Inflammatory bowel diseases 20071001

• The low frequency of defective TPMT alleles in Turkish population: a study on pediatric patients with acute lymphoblastic leukemia.

  American journal of hematology 20071001

• Corticosteroid-dependent eosinophilic oesophagitis: azathioprine and 6-mercaptopurine can induce and maintain long-term remission.

  European journal of gastroenterology & hepatology 20071001

• Medical management of mild to moderate Crohn's disease: evidence-based treatment algorithms for induction and maintenance of remission.

  Alimentary pharmacology & therapeutics 20071001

• [Common errors in the management of outpatients with inflammatory bowel disease].

  Gastroenterologia y hepatologia 20071001

• A critical analysis of barriers to the clinical implementation of pharmacogenomics.

  Therapeutics and clinical risk management 20071001

• Substitution of oral and intravenous thioguanine for mercaptopurine in a treatment regimen for children with standard risk acute lymphoblastic leukemia: a collaborative Children's Oncology Group/National Cancer Institute pilot trial (CCG-1942).

  Pediatric blood & cancer 20070901

• Mucormycosis presenting as recurrent gastric perforation in a patient with Crohn's disease on glucocorticoid, 6-mercaptopurine, and infliximab therapy.

  Digestive diseases and sciences 20070901

• Liver injury in inflammatory bowel disease: long-term follow-up study of 786 patients.

  Inflammatory bowel diseases 20070901

• Induction of acute lymphocytic leukemia differentiation by maintenance therapy.

  Leukemia 20070901

• Adverse reaction caused by excipients in mercaptopurine tablets.

  The Annals of pharmacotherapy 20070901

• Phase II study of chemotherapy and stem cell transplantation for adult acute lymphoblastic leukemia or lymphoblastic lymphoma: Japan Clinical Oncology Group Study 9004.

  Cancer science 20070901

• Sequential evaluation of thiopurine methyltransferase, inosine triphosphate pyrophosphatase, and HPRT1 genes polymorphisms to explain thiopurines' toxicity and efficacy.

  Alimentary pharmacology & therapeutics 20070901

• Oral tacrolimus for steroid-dependent and steroid-resistant ulcerative colitis in children.

  Journal of pediatric gastroenterology and nutrition 20070901

• Effect of long-term low-dose prednisone on height velocity and disease activity in pediatric and adolescent patients with Crohn disease.

  Journal of pediatric gastroenterology and nutrition 20070901

• Pharmacogenetic significance of inosine triphosphatase.

  Pharmacogenomics 20070901

• Relevance of pharmacogenetic aspects of mercaptopurine metabolism in the treatment of interstitial lung disease.

  Current opinion in pulmonary medicine 20070901

• Translation of pharmacogenetic knowledge into cancer therapeutics.

  Clinical advances in hematology & oncology : H&O 20070901

• The management of hemophilia in elderly patients.

  Clinical interventions in aging 20070901

• Antimetabolite therapy for lesser-risk B-lineage acute lymphoblastic leukemia of childhood: a report from Children's Oncology Group Study P9201.

  Blood 20070815

• Importance of a hypervariable active-site residue in human Mu class glutathione transferases catalyzing the bioactivation of chemotherapeutic thiopurine prodrugs.

  Biochimica et biophysica acta 20070801

• The efficiency of a PAMAM dendrimer toward the encapsulation of the antileukemic drug 6-mercaptopurine.

  Anti-cancer drugs 20070801

• Should we test TPMT enzyme levels before starting azathioprine?

  Hematology (Amsterdam, Netherlands) 20070801

• A triangulation study of the clinician and patient experiences of the use of the immunosuppressant drugs azathioprine and 6-mercaptopurine for the management of inflammatory bowel disease.

  Journal of clinical nursing 20070801

• Severe pulmonary toxicity after azathioprine/6-mercaptopurine initiation for the treatment of inflammatory bowel disease.

  Journal of clinical gastroenterology 20070801

• Pharmacogenomics in drug-metabolizing enzymes catalyzing anticancer drugs for personalized cancer chemotherapy.

  Current drug metabolism 20070801

• Translating pharmacogenomics: challenges on the road to the clinic.

  PLoS medicine 20070801

• In vitro study of 6-mercaptopurine oxidation catalysed by aldehyde oxidase and xanthine oxidase.

  Drug metabolism and pharmacokinetics 20070801

• The nucleoside and nucleotide mixture (OG-VI) rescues intestinal-like epithelial cells from the cytotoxicity of chemotherapeutic agents.

  The journal of medical investigation : JMI 20070801

• Solid-phase extraction and spectrophotometric determination of mercury with 6-mercaptopurine in environmental samples.

  Annali di chimica 20070801

• Adherence to thiopurine treatment in out-patients with Crohn's disease.

  Alimentary pharmacology & therapeutics 20070715

• Development of ulcerative colitis in a patient with multiple sclerosis following treatment with interferon beta 1a.

  World journal of gastroenterology 20070714

• Thiopurine-induced liver injury in patients with inflammatory bowel disease: a systematic review.

  The American journal of gastroenterology 20070701

• Therapeutic drug use in women with Crohn's disease and birth outcomes: a Danish nationwide cohort study.

  The American journal of gastroenterology 20070701

• 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial.

  Clinical chemistry 20070701

• The rate of hepatitis B and C virus infections and the importance of HBV vaccination in children with acute lymphoblastic leukemia.

  Hepatology research : the official journal of the Japan Society of Hepatology 20070701

• Immune response to influenza vaccine in pediatric patients with inflammatory bowel disease.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070701

• Medical therapy and birth outcomes in women with Crohn's disease: what should we tell our patients?

  The American journal of gastroenterology 20070701

• Disseminated intravascular coagulation in acute leukemia at presentation and during induction therapy.

  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20070701

• Leupeptin inhibits ventilator-induced diaphragm dysfunction in rats.

  American journal of respiratory and critical care medicine 20070601

• Pneumocystis jiroveci (carinii) pneumonia after infliximab therapy: a review of 84 cases.

  Digestive diseases and sciences 20070601

• Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs.

  Biochemical pharmacology 20070601

• Management of steroid-dependent ulcerative colitis: immunomodulatory agents, biologics, or surgery?

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070601

• Microscopic colitis.

  Current treatment options in gastroenterology 20070601

• [Current status of inflammatory bowel disease treatment].

  Revista clinica espanola 20070601

• Erythema nodosum-like eruption as a manifestation of azathioprine hypersensitivity in patients with inflammatory bowel disease.

  Archives of dermatology 20070601

• Evaluation of renal function in Turkish children receiving BFM-95 therapy for acute lymphoblastic leukemia.

  Pediatric hematology and oncology 20070601

• Hand-foot syndrome with scleroderma-like change induced by the oral capecitabine: a case report.

  The Korean journal of internal medicine 20070601

• [Treatment of chronic inflammatory bowel diseases].

  Bulletin de l'Academie nationale de medecine 20070601

• 6-Mercaptopurine, an activator of Nur77, enhances transcriptional activity of HIF-1alpha resulting in new vessel formation.

  Oncogene 20070531

• What can we learn from geographical comparisons of childhood cancer survival?

  British journal of cancer 20070521

• Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics.

  Cancer research 20070515

• Reinduction of relapsed acute promyelocytic leukemia with ATRA and low dose antimetabolite-based chemotherapy.

  Pediatric blood & cancer 20070501

• Studies of interactions among cobalt(III) polypyridyl complexes, 6-mercaptopurine and DNA.

  Bioelectrochemistry (Amsterdam, Netherlands) 20070501

• Application of HPLC to study the kinetics of a branched bi-enzyme system consisting of hypoxanthine-guanine phosphoribosyltransferase and xanthine oxidase--an important biochemical system to evaluate the efficiency of the anticancer drug 6-mercaptopurine in ALL cell line.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501

• Thiopurine methyltransferase activity in Spain: a study of 14,545 patients.

  Digestive diseases and sciences 20070501

• Assessment of thiopurine methyltransferase enzyme activity is superior to genotype in predicting myelosuppression following azathioprine therapy in patients with inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20070501

• Management of inflammatory bowel disease in adults.

  Journal of digestive diseases 20070501

• Thiopurine metabolite monitoring in paediatric inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20070415

• Synthesis and biological evaluation of some 6-substituted purines.

  European journal of medicinal chemistry 20070401

• Relationship between 6-mercaptopurine dose and 6-thioguanine nucleotide levels in patients with inflammatory bowel disease.

  Inflammatory bowel diseases 20070401

• Azathioprine and breastfeeding: is it safe?

  BJOG : an international journal of obstetrics and gynaecology 20070401

• Comment: Breast-feeding during maternal use of azathioprine.

  The Annals of pharmacotherapy 20070401

• Risk of fecal diversion in complicated perianal Crohn's disease.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20070401

• Impact of FLT3 internal tandem duplications on Indian acute promyelocytic leukemia patients: prognostic implications.

  Hematology (Amsterdam, Netherlands) 20070401

• Anticancer nucleobase analogues 6-mercaptopurine and 6-thioguanine are novel substrates for equilibrative nucleoside transporter 2.

  International journal of pharmaceutics 20070321

• T-cell acute lymphoblastic leukemia relapsing as acute myelogenous leukemia.

  Pediatric blood & cancer 20070301

• Autologous transplantation of CD133 selected hematopoietic progenitor cells for treatment of relapsed acute lymphoblastic leukemia.

  Pediatric blood & cancer 20070301

• Adolescents with acute lymphoblastic leukaemia: outcome on UK national paediatric (ALL97) and adult (UKALLXII/E2993) trials.

  Pediatric blood & cancer 20070301

• Improved outcome in childhood acute myeloid leukemia in Singapore with the MRC AML 10 protocol.

  Pediatric blood & cancer 20070301

• Should ileoanal pouch surgery be staged for patients with mucosal ulcerative colitis on immunosuppressives?

  International journal of colorectal disease 20070301

• Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light.

  DNA repair 20070301

• Synthesis and antiproliferative properties of N3/8-disubstituted 3,8-diazabicyclo[3.2.1]octane analogues of 3,8-bis[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl-piperazine.

  European journal of medicinal chemistry 20070301

• [Combination therapy with low-dose cyclosporin A, azathiopurine, and prednisolone for a child with refractory chronic idiopathic thrombocytopenic purpura].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 20070301

• 6-mercaptopurine (6-MP) entrapped stealth liposomes for improvement of leukemic treatment without hepatotoxicity and nephrotoxicity.

  Cancer investigation 20070301

• Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: results of an Austrian-German multicenter longitudinal study and implications for follow-up.

  Pediatric hematology and oncology 20070301

• Targeting nanomedicines in the treatment of Crohn's disease: focus on certolizumab pegol (CDP870).

  International journal of nanomedicine 20070301

• Isolated pulmonary Langerhans cell histiocytosis presenting with recurrent pneumothorax.

  Pediatric blood & cancer 20070201

• Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines.

  Investigational new drugs 20070201

• Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20070201

• Efficient screening method of the thiopurine methyltransferase polymorphisms for patients considering taking thiopurine drugs in a Chinese Han population in Henan Province (central China).

  Clinica chimica acta; international journal of clinical chemistry 20070201

• Results of the PETHEMA ALL-96 trial in elderly patients with Philadelphia chromosome-negative acute lymphoblastic leukemia.

  European journal of haematology 20070201

• Medium-term results of oral tacrolimus treatment in refractory inflammatory bowel disease.

  Inflammatory bowel diseases 20070201

• Pharmacogenomics in cancer treatment defining genetic bases for inter-individual differences in responses to chemotherapy.

  Current opinion in pediatrics 20070201

• Nonadherence with thiopurine immunomodulator and mesalamine medications in children with Crohn disease.

  Journal of pediatric gastroenterology and nutrition 20070201

• A nudge in the right direction: shaping the metabolic fate of thiopurines for therapeutic gain.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070201

• Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070201

• Crohn's disease of the esophagus.

  Current treatment options in gastroenterology 20070201

• Monitoring of thiopurine methyltransferase activity in postsurgical patients with Crohn's disease during 1 year of treatment with azathioprine or mesalazine.

  Therapeutic drug monitoring 20070201

• Analysis of ITPA phenotype-genotype correlation in the Bulgarian population revealed a novel gene variant in exon 6.

  Therapeutic drug monitoring 20070201

• Nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase--enzymatic reaction pathways of 6-mercaptopurine and 2-mercaptopurine are different.

  Biochemistry. Biokhimiia 20070201

• Activation of nuclear receptor Nur77 by 6-mercaptopurine protects against neointima formation.

  Circulation 20070130

• Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis.

  The Cochrane database of systematic reviews 20070124

• Prognostic role of the reduced folate carrier, the major membrane transporter for methotrexate, in childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070115

• Pulses of vincristine and dexamethasone in addition to intensive chemotherapy for children with intermediate-risk acute lymphoblastic leukaemia: a multicentre randomised trial.

  Lancet (London, England) 20070113

• Targeting the cerebrovascular large neutral amino acid transporter (LAT1) isoform using a novel disulfide-based brain drug delivery system.

  Drug delivery 20070101

• Radiation-induced meningioma following prophylactic radiotherapy for acute lymphoblastic leukemia in childhood.

  Pediatric neurosurgery 20070101

• Meta-analysis of risk of malignancy with immunosuppressive drugs in inflammatory bowel disease.

  The Annals of pharmacotherapy 20070101

• Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease.

  Inflammatory bowel diseases 20070101

• Pouch outcomes among children with ulcerative colitis treated with calcineurin inhibitors before ileal pouch anal anastomosis surgery.

  Journal of pediatric surgery 20070101

• Birth outcome in women treated with azathioprine or mercaptopurine during pregnancy: A Danish nationwide cohort study.

  Alimentary pharmacology & therapeutics 20070101

• [Case of severe ulcerative colitis successfully treated with intravenous cyclosporine without high dose corticosteroid].

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20070101

• Steroid treatment for severe acute cryptogenic hepatitis.

  Zeitschrift fur Gastroenterologie 20070101

• On the action of methotrexate and 6-mercaptopurine on M. avium subspecies paratuberculosis.

  PloS one 20070101

• Individualized drug therapy.

  Current opinion in drug discovery & development 20070101

• Inflammatory bowel disease: past, present, and future.

  Journal of gastroenterology 20070101

• Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing.

  Clinical pharmacokinetics 20070101

• Gastroparesis in patients with inactive Crohn's disease: a case series.

  BMC gastroenterology 20070101

• Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout.

  International journal of medical sciences 20070101

• Impact of pharmacogenomics on clinical practice in oncology.

  Molecular diagnosis & therapy 20070101

• Genetic tests for predicting the toxicity and efficacy of anticancer chemotherapy.

  Neoplasma 20070101

• Eruptive post-chemotherapy in situ melanomas and dysplastic nevi.

  Pediatric dermatology 20070101

• Adolescent adherence to oral therapy for leukemia: a focus group study.

  Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses 20070101

• [Influence of antitumor preparations on the concentration of free radicals in cells of Fusarium bulbigenum var. blasticola fungus during primary and tumour-like secondary growth].

  Biofizika 20070101

• Resolution of disseminated fusariosis in a child with acute leukemia treated with combined antifungal therapy: a case report.

  BMC infectious diseases 20070101

• Preferential inhibition of xanthine oxidase by 2-amino-6-hydroxy-8-mercaptopurine and 2-amino-6-purine thiol.

  BMC biochemistry 20070101

• Daunorubicin-induced cell kill with 1-hour versus 24-hour infusions: a randomized comparison in children with newly diagnosed acute lymphoblastic leukemia.

  Klinische Padiatrie 20070101

• The patient with persistent perianal fistulae.

  Best practice & research. Clinical gastroenterology 20070101

• On the action of 5-amino-salicylic acid and sulfapyridine on M. avium including subspecies paratuberculosis.

  PloS one 20070101

• [Modified BFM-90 regimen greatly improves treatment outcomes of chinese childhood and adolescent lymphoblastic lymphoma].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20070101

• Fludarabine, treosulfan and etoposide sensitivity and the outcome of hematopoietic stem cell transplantation in childhood acute myeloid leukemia.

  Anticancer research 20070101

• [Comparison of the present and previously used protocol of risk stratification in children with acute lymphoblastic leukemia].

  Medycyna wieku rozwojowego 20070101

• Long-term graft function after allogeneic islet transplantation.

  Cell transplantation 20070101

• Infliximab therapy in children and adolescents with inflammatory bowel disease.

  Drugs 20070101

• Thiopurine treatment in inflammatory bowel disease.

  Clinical pharmacokinetics 20070101

• [The results of a multicenter trial of acute lymphoblastic leukemia treatment on ALL-MB 91/ALL-BFM 90m in children: analysis of efficacy and toxicity].

  Terapevticheskii arkhiv 20070101

• Crystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferase.

  BMC structural biology 20070101

• [Combination of purine analogues and aminosalicylates in patients with inflammatory bowel disease: why and how?].

  Gastroenterologie clinique et biologique 20070101

• [Clinical manifestation of hepatotoxic effect of cytostatic chemicals].

  Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20070101

• Azathioprine: a guide for the management of dermatology patients.

  Dermatologic therapy 20070101

• Myasthenia gravis.

  Orphanet journal of rare diseases 20070101

• Morphine in children with cancer: impact of age, chemotherapy and other factors on protein binding.

  Journal of pain & palliative care pharmacotherapy 20070101

• Acute lymphoblastic leukemia in a patient with chronic cyanoacrylate exposure.

  Acta haematologica 20070101

• Azathioprine in dermatology.

  Acta dermatovenerologica Croatica : ADC 20070101

• Maintenance of medically induced remission of Crohn's disease.

  Digestion 20070101

• Maintenance of surgically induced remission of Crohn's disease.

  Digestion 20070101

• Extraintestinal manifestations of Crohn's disease.

  Digestion 20070101

• Pregnancy and breastfeeding in patients with Crohn's disease.

  Digestion 20070101

• Drug safety in Crohn's disease therapy.

  Digestion 20070101

• Survival analysis.

  Methods in molecular biology (Clifton, N.J.) 20070101

• Infliximab: the evidence for its place in therapy in ulcerative colitis.

  Core evidence 20070101

• Certolizumab pegol: an evidence-based review of its place in the treatment of Crohn's disease.

  Core evidence 20070101

• Refractory ulcerative colitis treatment.

  Gastroenterology & hepatology 20070101

• Body mass index does not influence pharmacokinetics or outcome of treatment in children with acute lymphoblastic leukemia.

  Blood 20061215

• Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases.

  Journal of medicinal chemistry 20061214

• Authenticity and drug resistance in a panel of acute lymphoblastic leukaemia cell lines.

  British journal of cancer 20061204

• In vivo comparison of various polymeric and low molecular mass inhibitors of intestinal P-glycoprotein.

  Biomaterials 20061201

• Avascular necrosis--an antineoplastic-treatment-related toxicity: the experiences of two institutions.

  Pediatric hematology and oncology 20061201

• Insights in immunomodulatory therapies for ulcerative colitis and Crohn's disease.

  Current gastroenterology reports 20061201

• Adding pharmacogenetics information to drug labels: lessons learned.

  Pharmacogenetics and genomics 20061201

• Infliximab in ulcerative colitis.

  Gastroenterology clinics of North America 20061201

• Breast-feeding during maternal use of azathioprine.

  The Annals of pharmacotherapy 20061201

• Analysis of thiopurine S-methyltransferase polymorphism in the population of Serbia and Montenegro and mercaptopurine therapy tolerance in childhood acute lymphoblastic leukemia.

  Therapeutic drug monitoring 20061201

• Childhood CD4+/CD56+ hematodermic neoplasm: case report and review of the literature.

  Haematologica 20061201

• Favourable outcome in an APL patient with PLZF/RARalpha fusion gene: quantitative real-time RT-PCR confirms molecular response.

  Haematologica 20061201

• Review article: Medical therapy for fistulizing Crohn's disease.

  Alimentary pharmacology & therapeutics 20061101

• [Monitoring of thiopurine methyltransferase and thiopurine metabolites to optimize azathioprine therapy in inflammatory bowel disease].

  Gastroenterologia y hepatologia 20061101

• [Risk of postoperative infection in patients with inflammatory bowel disease].

  The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20061101

• Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) treated with 2-chlorodeoxyadenosine.

  Pediatric blood & cancer 20061015

• Thioguanine versus mercaptopurine in childhood ALL.

  Lancet (London, England) 20061014

• Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial.

  Lancet (London, England) 20061014

• Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease.

  Gut 20061001

• Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis.

  Journal of hepatology 20061001

• Decreased activity of clotting factor V during ALL consolidation treatment with mercaptopurine in a child.

  The Annals of pharmacotherapy 20061001

• Review article: can post-operative recurrence in Crohn's disease be prevented?

  Alimentary pharmacology & therapeutics 20061001

• Review article: the effect of aminosalicylates and immunomodulation on cancer risk in inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20061001

• Azathioprine as a postoperative prophylaxis reduces symptoms in aggressive Crohn's disease.

  Scandinavian journal of gastroenterology 20061001

• Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs.

  British journal of clinical pharmacology 20061001

• Leukocytapheresis in patients with moderate-severe steroid-dependant ulcerative colitis: clinical response without endoscopic response.

  Inflammatory bowel diseases 20061001

• The thiopurine methyltransferase genetic polymorphism is associated with thioguanine-related veno-occlusive disease of the liver in children with acute lymphoblastic leukemia.

  Clinical pharmacology and therapeutics 20061001

• Treatment of acute myeloid leukemia patients aged more than 75 years: results of the E-AML-01 trial of the Japanese Elderly Leukemia and Lymphoma Study Group (JELLSG).

  Leukemia & lymphoma 20061001

• [Postoperative recurrence in Crohn's disease. Risk factors and methods of prevention].

  La Tunisie medicale 20061001

• [The clinical features of B cell lymphoblastic lymphoma and outcomes after BFM-90 regimen therapy].

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20061001

• Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside.

  Biochemical pharmacology 20060928

• A synthetic route to 9-(polyhydroxyalkyl)purines.

  Carbohydrate research 20060925

• Assembling of dimeric entities of Cd(II) with 6-mercaptopurine to afford one-dimensional coordination polymers: synthesis and scanning probe microscopy characterization.

  Inorganic chemistry 20060918

• Oral outpatient chemotherapy medication errors in children with acute lymphoblastic leukemia.

  Cancer 20060915

• Stabilization of gold nanoparticles by 6-mercaptopurine monolayers. Effects of the solvent properties.

  The journal of physical chemistry. B 20060914

• Symptomatic hypoglycemia: an unusual side effect of oral purine analogues for treatment of ALL.

  Pediatric blood & cancer 20060901

• Reduction in bioavailability of 6-mercaptopurine on simultaneous administration with cow's milk.

  Pediatric hematology and oncology 20060901

• Azathioprine in dermatology: the past, the present, and the future.

  Journal of the American Academy of Dermatology 20060901

• Review article: thiopurines in inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20060901

• [A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient].

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20060901

• Next steps on the thiopurine methyltransferase 6-thioguanine nucleotide pathway.

  Journal of pediatric gastroenterology and nutrition 20060901

• Evolution of thiopurine use in pediatric inflammatory bowel disease in an academic center.

  Journal of pediatric gastroenterology and nutrition 20060901

• [Twenty years of treating childhood acute lymphoblastic leukemia].

  Anales de pediatria (Barcelona, Spain : 2003) 20060901

• Lack of cross-reactivity between 5-aminosalicylic acid-based drugs: a case report and review of the literature.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060901

• AIDS-associated Burkitt or Burkitt-like lymphoma: short intensive polychemotherapy is feasible and effective.

  Leukemia & lymphoma 20060901

• Treatment of recurrent Langerhans cell histiocytosis in children with 2-chlorodeoxyadenosine.

  Leukemia & lymphoma 20060901

• Asparaginase (native ASNase or pegylated ASNase) in the treatment of acute lymphoblastic leukemia.

  International journal of nanomedicine 20060901

• Cancer treatment-induced mucositis pain: strategies for assessment and management.

  Therapeutics and clinical risk management 20060901

• Nine-year survival of lymphoblastic lymphoma patients.

  Yonsei medical journal 20060831

• Divergent activities of human glutathione transferases in the bioactivation of azathioprine.

  Molecular pharmacology 20060801

• Incidence of neoplasms in patients who develop sustained leukopenia during or after treatment with 6-mercaptopurine for inflammatory bowel disease.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20060801

• TPMT, UGT1A1 and DPYD: genotyping to ensure safer cancer therapy?

  Trends in pharmacological sciences 20060801

• Case report: lymphoma arising in an ileal pouch anal anastomosis after immunomodulatory therapy for inflammatory bowel disease.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20060801

• Genetic variants and the risk of Crohn's disease: what does it mean for future disease management?

  Expert opinion on pharmacotherapy 20060801

• Physical activity during treatment in children with leukemia: a pilot study.

  Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 20060801

• Remission on thiopurinic immunomodulators normalizes quality of life and psychological status in patients with Crohn's disease.

  Inflammatory bowel diseases 20060801

• Severe muscular weakness: an unusual adverse effect of azathioprine therapy.

  Journal of clinical gastroenterology 20060801

• Adverse events leading to modification of therapy in a large cohort of patients with inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20060715

• Synthesis, hydrolyses and dermal delivery of N-alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) derivatives of phenol, imide and thiol containing drugs.

  Bioorganic & medicinal chemistry letters 20060701

• Systematic review of postoperative complications in patients with inflammatory bowel disease treated with immunomodulators.

  The British journal of surgery 20060701

• Postoperative maintenance therapy for inflammatory bowel disease.

  Current opinion in gastroenterology 20060701

• Bis(6-thioxo-1,6-dihydropurinium) tetrachlorozincate(II).

  Acta crystallographica. Section C, Crystal structure communications 20060701

• Pharmacogenetics in inflammatory bowel disease.

  World journal of gastroenterology 20060621

• Inhibition of inducible nitric oxide synthesis by azathioprine in a macrophage cell line.

  Life sciences 20060620

• Erythrocyte concentrations of metabolites or cumulative doses of 6-mercaptopurine and methotrexate do not predict liver changes in children treated for acute lymphoblastic leukemia.

  Pediatric blood & cancer 20060601

• Outcome of treatment in adults with Philadelphia chromosome-positive and/or BCR-ABL--positive acute lymphoblastic leukemia-retrospective analysis of Polish Adult Leukemia Group (PALG).

  Annals of hematology 20060601

• TR3 nuclear orphan receptor prevents cyclic stretch-induced proliferation of venous smooth muscle cells.

  The American journal of pathology 20060601

• Management of refractory ulcerative colitis.

  Current treatment options in gastroenterology 20060601

• Primary endobronchial anaplastic large cell lymphoma in a pediatric patient.

  Puerto Rico health sciences journal 20060601

• Does intravenous 6-mercaptopurine decrease salvage after relapse in childhood acute lymphoblastic leukemia?

  Pediatric blood & cancer 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• The significance of minimal residual disease kinetics in adults with newly diagnosed PML-RARalpha-positive acute promyelocytic leukemia: results of a prospective trial.

  Haematologica 20060501

• [HPLC determination and diversity analysis of thiopurine methyltransferase activity in human and pig].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060501

• Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines.

  Biochemical and biophysical research communications 20060428

• Determination of 6-mercaptopurine based on the fluorescence enhancement of Au nanoparticles.

  Talanta 20060415

• Monitoring of inosine monophosphate dehydrogenase activity in mononuclear cells of children with acute lymphoblastic leukemia: enzymological and clinical aspects.

  Pediatric blood & cancer 20060401

• Del(5q) and MLL amplification in homogeneously staining region in acute myeloblastic leukemia: a recurrent cytogenetic association.

  Annals of hematology 20060401

• 6-Thioguanine-related hepatotoxicity in patients with inflammatory bowel disease: dose or level dependent?

  Journal of hepatology 20060401

• Risk of lymphoma: inflammatory bowel disease and immunomodulators.

  Gut 20060401

• Role of treatment intensification in infants with acute lymphoblastic leukemia: results of two consecutive AIEOP studies.

  Haematologica 20060401

• Chemoprevention of colorectal neoplasia in ulcerative colitis: the effect of 6-mercaptopurine.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20060401

• Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis.

  Gastroenterology 20060401

• Infliximab plus azathioprine for steroid-dependent Crohn's disease patients: a randomized placebo-controlled trial.

  Gastroenterology 20060401

• When is too much enough?

  Gastroenterology 20060401

• Infliximab and azathioprine: bridge or parachute?

  Gastroenterology 20060401

• 5-aminosalicylate therapy is associated with higher 6-thioguanine levels in adults and children with inflammatory bowel disease in remission on 6-mercaptopurine or azathioprine.

  Inflammatory bowel diseases 20060401

• Pregnane glycosides from Leptadenia pyrotechnica.

  Journal of natural products 20060401

• Inflammatory bowel disease in children: a pediatrician's perspective.

  Minerva pediatrica 20060401

• [Experimental methods in the treatment of Leśniowski-Crohn disease].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20060401

• Infliximab for ulcerative colitis.

  The New England journal of medicine 20060330

• Orientation of 6-mercaptopurine SAMs at the silver electrode as studied by Raman mapping and in situ SERS.

  The journal of physical chemistry. B 20060323

• Case records of the Massachusetts General Hospital. Case 8-2006. A 71-year-old woman with Crohn's disease and altered mental status.

  The New England journal of medicine 20060316

• Leflunomide prevents alveolar fluid clearance inhibition by respiratory syncytial virus.

  American journal of respiratory and critical care medicine 20060315

• Chromosomal change during 6-mercaptopurine (6-MP) therapy in juvenile myelomonocytic leukemia: the growth of a 6-MP-refractory clone that already exists at onset.

  Leukemia 20060301

• Roles of protein C, protein S, and antithrombin III in acute leukemia.

  American journal of hematology 20060301

• American Gastroenterological Association Institute medical position statement on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease.

  Gastroenterology 20060301

• American Gastroenterological Association Institute technical review on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease.

  Gastroenterology 20060301

• Prevalence of methylenetetrahydrofolate reductase polymorphisms in young patients with inflammatory bowel disease.

  Digestive diseases and sciences 20060301

• How low is too low? Use of cluster analysis to define low levels of mercaptopurine metabolites.

  Pediatric blood & cancer 20060201

• Treatment adherence and 6-mercaptopurine metabolites.

  Pediatric blood & cancer 20060201

• Chronic liver disease related to 6-thioguanine in children with acute lymphoblastic leukaemia.

  Journal of hepatology 20060201

• Growth hormone deficiency after chemotherapy for acute lymphoblastic leukemia in children who have not received cranial radiation.

  Pediatric blood & cancer 20060201

• Predictors of immunomodulator use as early therapy in pediatric Crohn's disease.

  Journal of clinical gastroenterology 20060201

• Treatment of severe disseminated juvenile systemic xanthogranuloma with multiple lesions in the central nervous system.

  Journal of pediatric hematology/oncology 20060201

• JPN Guidelines for the management of acute pancreatitis: epidemiology, etiology, natural history, and outcome predictors in acute pancreatitis.

  Journal of hepato-biliary-pancreatic surgery 20060201

• [Wegener's granulomatosis: Pathogenesis, pathophysiology, and therapy].

  Nihon rinsho. Japanese journal of clinical medicine 20060201

• Mechanistic mathematical modelling of mercaptopurine effects on cell cycle of human acute lymphoblastic leukaemia cells.

  British journal of cancer 20060116

• Thiopurine methyltransferase in acute lymphoblastic leukemia.

  Blood 20060115

• Is thiopurine therapy in ulcerative colitis as effective as in Crohn's disease?

  Gut 20060101

• Cyclosporine for severe ulcerative colitis.

  The Annals of pharmacotherapy 20060101

• Toxicity of infliximab in the course of treatment of Crohn's disease.

  Expert opinion on drug safety 20060101

• Pharmacogenomics and individualized drug therapy.

  Annual review of medicine 20060101

• Pharmacogenomics in inflammatory bowel disease.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20060101

• A rash imposition from a lifestyle omission: a case report of pellagra.

  The Ulster medical journal 20060101

• Pharmacogenetics, adverse drug reactions and public health.

  Community genetics 20060101

• 6-Thioguanine treatment in inflammatory bowel disease: a critical appraisal by a European 6-TG working party.

  Digestion 20060101

• Inflammatory bowel disease: current therapeutic options.

  Digestion 20060101

• Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer.

  Clinical pharmacokinetics 20060101

• The NR4A subgroup: immediate early response genes with pleiotropic physiological roles.

  Nuclear receptor signaling 20060101

• Anti-inflammatory and immunosuppressive drugs and reproduction.

  Arthritis research & therapy 20060101

• Choice of azathioprine or 6-mercaptopurine dose based on thiopurine methyltransferase (TPMT) activity to avoid myelosuppression. A prospective study.

  Hepato-gastroenterology 20060101

• Efficacy and tolerability of gemtuzumab ozogamicin (anti-CD33 monoclonal antibody, CMA-676, Mylotarg) in children with relapsed/refractory myeloid leukemia.

  BMC cancer 20060101

• The early history of chemical immunosuppression: 1900-1965.

  Journal of nephrology 20060101

• Overcoming the force and power of immunity: a history of immunosuppression in kidney transplantation.

  Journal of nephrology 20060101

• [Pharmacogenetics and pharmacogenomics].

  Bulletin de l'Academie nationale de medecine 20060101

• [Xenobiotic-metabolizing polymorphic enzymes. An opportunity for individualized drug treatment].

  Bulletin de l'Academie nationale de medecine 20060101

• Successful management of cerebral and pulmonary mucormycosis with liposomal amphotericin B in a 28-year-old woman with acute lymphoblastic leukemia.

  Acta bio-medica : Atenei Parmensis 20060101

• Guidelines for treatment with infliximab for Crohn's disease.

  The Netherlands journal of medicine 20060101

• Antidepressants and inflammatory bowel disease: a systematic review.

  Clinical practice and epidemiology in mental health : CP & EMH 20060101

• [Otoacoustic emissions measurements in children during the chemotherapy because of the acute lymphoblastic leukemia].

  Otolaryngologia polska = The Polish otolaryngology 20060101

• Langerhans cell histiocytosis on the penis: a case report.

  BMC urology 20060101

• Current therapy of inflammatory bowel disease in children.

  Paediatric drugs 20060101

• No induction of thiopurine methyltransferase during thiopurine treatment in inflammatory bowel disease.

  Nucleosides, nucleotides & nucleic acids 20060101

• Impaired transport as a mechanism of resistance to thiopurines in human T-lymphoblastic leukemia cells.

  Nucleosides, nucleotides & nucleic acids 20060101

• Determination of ITPase activity in erythrocyte lysates obtained for determination of TPMT activity.

  Nucleosides, nucleotides & nucleic acids 20060101

• Acute ascending motoric paraplegia following intrathecal chemotherapy for treatment of acute lymphoblastic leukemia in children: case reports and review of the literature.

  Klinische Padiatrie 20060101

• Cytotoxic drug sensitivity of Epstein-Barr virus transformed lymphoblastoid B-cells.

  BMC cancer 20060101

• Thiopurine S-methyltransferase phenotype-genotype correlation in hemodialyzed patients.

  Pharmacological reports : PR 20060101

• Thiopurines, DNA damage, DNA repair and therapy-related cancer.

  British medical bulletin 20060101

• [Reults of treatment with protocols BFM 90 and BFM 95].

  Medicinski arhiv 20060101

• [Auditory evoked potentials in patients after acute children's lymphoblastic leukemia treatment].

  Przeglad lekarski 20060101

• Clinical pharmacogenomics of thiopurine S-methyltransferase.

  Current clinical pharmacology 20060101

• Medical management of Crohn's disease: current therapy and recent advances.

  Expert review of clinical immunology 20060101

• A randomized, postremission comparison of four courses of standard-dose consolidation therapy without maintenance therapy versus three courses of standard-dose consolidation with maintenance therapy in adults with acute myeloid leukemia: the Japan Adult Leukemia Study Group AML 97 Study.

  Cancer 20051215

• TPMT genotype and the use of thiopurines in paediatric inflammatory bowel disease.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20051201

• The thiopurines: an update.

  Investigational new drugs 20051201

• Observations on the use of allopurinol in combination with azathioprine or mercaptopurine.

  Alimentary pharmacology & therapeutics 20051201

• Managing complicated Crohn's disease in children and adolescents.

  Nature clinical practice. Gastroenterology & hepatology 20051201

• West Nile virus infection in a teenage boy with acute lymphocytic leukemia in remission.

  Journal of pediatric hematology/oncology 20051201

• Simultaneous control of third-degree graft-versus-host disease and prevention of recurrence of juvenile myelomonocytic leukemia (JMML) with 6-mercaptopurine following fulminant JMML relapse early after KIR-mismatched bone marrow transplantation.

  Journal of pediatric hematology/oncology 20051201

• p16 inactivation associated with aggressive clinical course and fatal outcome in TEL/AML1-positive acute lymphoblastic leukemia.

  Journal of pediatric hematology/oncology 20051201

• Role of 5'-nucleotidase in thiopurine metabolism: enzyme kinetic profile and association with thio-GMP levels in patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment.

  Clinica chimica acta; international journal of clinical chemistry 20051101

• Toxicity due to 6-thioquanine.

  Pediatric blood & cancer 20051101

• Effects of azathioprine and its metabolites on repair mechanisms of the intestinal epithelium in vitro.

  Regulatory peptides 20051101

• Liquid chromatography-tandem mass spectrometry analysis of erythrocyte thiopurine nucleotides and effect of thiopurine methyltransferase gene variants on these metabolites in patients receiving azathioprine/6-mercaptopurine therapy.

  Clinical chemistry 20051101

• Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics.

  Pharmacogenetics and genomics 20051101

• Incidence, risk factors and clinical course of thiopurine-induced liver injury in patients with inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20051101

• Lymphoma after Imuran and 6-MP: a new look.

  Journal of pediatric gastroenterology and nutrition 20051101

• Drug therapy for the treatment of Langerhans cell histiocytosis.

  Expert opinion on pharmacotherapy 20051101

• Membranous glomerulopathy in children given allogeneic hematopoietic stem cell transplantation.

  Haematologica 20051101

• Intracranial plasma cell granuloma: case report and treatment of recurrence with methotrexate and 6-mercaptopurine.

  Journal of pediatric hematology/oncology 20051101

• 6-Thioguanine for Crohn's disease during pregnancy: thiopurine metabolite measurements in both mother and child.

  Scandinavian journal of gastroenterology 20051101

• Alert: 6-mercaptopurine may be erroneously dispensed instead of propylthiouracil.

  Thyroid : official journal of the American Thyroid Association 20051101

• Treatment with all-trans retinoic acid and anthracycline monochemotherapy for children with acute promyelocytic leukemia: a multicenter study by the PETHEMA Group.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051020

• [Crohn's disease--standards of treatment 2004].

  Praxis 20051012

• The risk of lymphoma in the treatment of inflammatory bowel disease with immunosuppressive agents.

  Critical reviews in oncology/hematology 20051001

• Low-dose oral methotrexate for maintaining Crohn's disease remission: where we stand.

  Journal of clinical gastroenterology 20051001

• Genetic determinants of cancer drug efficacy and toxicity: practical considerations and perspectives.

  Anti-cancer drugs 20051001

• The impact of age and gender on biology, clinical features and treatment outcome of non-Hodgkin lymphoma in childhood and adolescence.

  British journal of haematology 20051001

• Thiopurine therapies: problems, complexities, and progress with monitoring thioguanine nucleotides.

  Therapeutic drug monitoring 20051001

• The pharmacokinetic effect of discontinuation of mesalazine on mercaptopurine metabolite levels in inflammatory bowel disease patients.

  Alimentary pharmacology & therapeutics 20051001

• A cost-effectiveness analysis of alternative disease management strategies in patients with Crohn's disease treated with azathioprine or 6-mercaptopurine.

  The American journal of gastroenterology 20051001

• Thiopurine methyltransferase and 6-thioguanine nucleotide measurement: early experience of use in clinical practice.

  Internal medicine journal 20051001

• Chemoprevention of colorectal neoplasia in ulcerative colitis: the effect of 6-mercaptopurine.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20051001

• Excellent response of chemotherapy-resistant B-cell-type chronic lymphocytic leukemia with meningeal involvement to rituximab.

  International journal of clinical oncology 20051001

• A prospective, open-label trial of 6-thioguanine in patients with ulcerative or indeterminate colitis.

  Scandinavian journal of gastroenterology 20051001

• On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprine or 6-mercaptopurine intolerant IBD patients.

  World journal of gastroenterology 20050921

• [Thiopurine methyltransferase activity in inflammatory bowel disease. A study on 7046 Spanish patients].

  Medicina clinica 20050910

• [Erythrocyte activity of thiopurine methyltransferase and treatment with thiopurines in inflammatory bowel disease].

  Medicina clinica 20050910

• Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment.

  Blood 20050901

• Fluorometric investigation of the interaction of bovine serum albumin with surfactants and 6-mercaptopurine.

  Journal of photochemistry and photobiology. B, Biology 20050901

• The yicM (nepI) gene of Escherichia coli encodes a major facilitator superfamily protein involved in efflux of purine ribonucleosides.

  FEMS microbiology letters 20050901

• Drug-induced pancreatitis: an update.

  Journal of clinical gastroenterology 20050901

• Azathioprine pancreatitis in inflammatory bowel disease and successful subsequent treatment with mercaptopurine.

  Internal medicine journal 20050901

• Allopurinol safely and effectively optimizes tioguanine metabolites in inflammatory bowel disease patients not responding to azathioprine and mercaptopurine.

  Alimentary pharmacology & therapeutics 20050901

• On the limitation of 6-tioguaninenucleotide monitoring during tioguanine treatment.

  Alimentary pharmacology & therapeutics 20050901

• Nuclear winter.

  Transfusion 20050901

• A survey of Canadian gastroenterologists about the use of methotrexate in patients with Crohn's disease.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20050901

• Pharmacokinetics of azathioprine following single-dose intravenous and oral administration and effects of azathioprine following chronic oral administration in horses.

  American journal of veterinary research 20050901

• Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles.

  British journal of cancer 20050822

• Adsorption of 6-mercaptopurine and 6-mercaptopurine-ribosideon silver colloid: a pH-dependent surface-enhanced Raman spectroscopy and density functional theory study. II. 6-mercaptopurine-riboside.

  Biopolymers 20050815

• [Epstein-Barr virus-related lymphomas in patients with inflammatory bowel disease].

  Nederlands tijdschrift voor geneeskunde 20050813

• Suboptimal physician adherence to quality indicators for the management of gout and asymptomatic hyperuricaemia: results from the UK General Practice Research Database (GPRD).

  Rheumatology (Oxford, England) 20050801

• Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine.

  Gut 20050801

• Use of endoscopic ultrasound to guide combination medical and surgical therapy for patients with Crohn's perianal fistulas.

  Inflammatory bowel diseases 20050801

• The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients.

  Therapeutic drug monitoring 20050801

• Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.

  Journal of gastroenterology and hepatology 20050801

• Successful bone marrow transplantation for life threatening xanthogranuloma disseminatum in neurofibromatosis type-1.

  Pediatric transplantation 20050801

• Liposomal formulations of inflammatory bowel disease drugs: local versus systemic drug delivery in a rat model.

  Pharmaceutical research 20050801

• Development of hepatocellular carcinoma following treatment with 6-mercaptopurine for ulcerative colitis: investigation of chromosomal aberration by comparative genomic hybridization.

  International journal of clinical oncology 20050801

• Interventions for growth failure in childhood Crohn's disease.

  The Cochrane database of systematic reviews 20050720

• Factors affecting recurrence after surgery for Crohn's disease.

  World journal of gastroenterology 20050714

• Interference free and simplyfied liquid chromatography-based determination of thiopurine S-methyltransferase activity in erythrocytes.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050705

• Intravenous 6-mercaptopurine decreases salvage after relapse in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group study CCG 1922.

  Pediatric blood & cancer 20050701

• Do minor differences in primary therapy influence rescue-ability after relapse in childhood ALL?

  Pediatric blood & cancer 20050701

• In vitro activity of imatinib in cells from patients with adult acute lymphoblastic leukemia.

  Anti-cancer drugs 20050701

• Thiopurine S-methyltransferase as a target for drug interactions.

  European journal of clinical pharmacology 20050701

• Review article: practical management of inflammatory bowel disease patients taking immunomodulators.

  Alimentary pharmacology & therapeutics 20050701

• Rosai-Dorfman disease: successful long-term results by combination chemotherapy with prednisone, 6-mercaptopurine, methotrexate, and vinblastine: a case report.

  International journal of surgical pathology 20050701

• Modeling of purine derivatives transport across cell membranes based on their partition coefficient determination and quantum chemical calculations.

  Journal of medicinal chemistry 20050630

• Pharmacogenetics of outcome in children with acute lymphoblastic leukemia.

  Blood 20050615

• Immunophenotypic cell lineage and in vitro cellular drug resistance in childhood relapsed acute lymphoblastic leukaemia.

  European journal of cancer (Oxford, England : 1990) 20050601

• Predicting drug response and toxicity based on gene polymorphisms.

  Critical reviews in oncology/hematology 20050601

• Appropriateness of immunosuppressive drugs in inflammatory bowel diseases assessed by RAND method: Italian Group for IBD (IG-IBD) position statement.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20050601

• Pediatric inflammatory bowel disease: what children can teach adults.

  Inflammatory bowel diseases 20050601

• Are patients with inflammatory bowel disease receiving optimal care?

  The American journal of gastroenterology 20050601

• Determination of mercaptopurine and its four metabolites by large-volume sample stacking with polarity switching in capillary electrophoresis.

  Electrophoresis 20050601

• Azathioprine, 6-mercaptopurine and thiopurine S-methyltransferase.

  Journal of gastroenterology and hepatology 20050601

• TRAP220 is modulated by the antineoplastic agent 6-Mercaptopurine, and mediates the activation of the NR4A subgroup of nuclear receptors.

  Journal of molecular endocrinology 20050601

• Screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides.

  Biotechnology letters 20050601

• Pyoderma gangrenosum associated with osteomyelitis in a paediatric patient: a case report.

  The West Indian medical journal 20050601

• [Pharmacogenetics of inflammatory bowel disease].

  Orvosi hetilap 20050522

• [Individual monitoring of thiopurine and methotrexate treatment].

  Ugeskrift for laeger 20050516

• [Immunosuppressive agents: Imurel and Purinethol].

  La Revue du praticien 20050515

• Value of intravenous 6-mercaptopurine during continuation treatment in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma: final results of a randomized phase III trial (58881) of the EORTC CLG.

  Leukemia 20050501

• The effect of 6-mercaptopurine on early human placental explants.

  Human reproduction (Oxford, England) 20050501

• Immunosuppressive efficacy of mycophenolate mofetil when compared with azathioprine and mizoribine against peripheral lymphocytes from renal transplant recipients.

  Transplant international : official journal of the European Society for Organ Transplantation 20050501

• Effects of aminosalicylates on thiopurine S-methyltransferase activity: an ex vivo study in patients with inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20050501

• Preventing postoperative recurrence in Crohn's disease with 6-mercaptopurine and azathioprine: approaching the cutting edge.

  Inflammatory bowel diseases 20050501

• [Immunosuppressants for therapy of patients with ulcerative colitis].

  Nihon rinsho. Japanese journal of clinical medicine 20050501

• [Guidelines for treatment of ulcerative colitis in children].

  Nihon rinsho. Japanese journal of clinical medicine 20050501

• Amphotericin B-induced nephrogenic diabetes insipidus in a case of cryptococcemia.

  Internal medicine (Tokyo, Japan) 20050501

• [Azathioprine].

  Nihon rinsho. Japanese journal of clinical medicine 20050501

• Azathioprine induced nodular regenerative hyperplasia in IBD patients.

  Gastroenterologie clinique et biologique 20050501

• ITPA genotyping test does not improve detection of Crohn's disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression.

  Gut 20050401

• Promising treatment of autoimmune hepatitis with 6-thioguanine after adverse events on azathioprine.

  European journal of gastroenterology & hepatology 20050401

• Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20050401

• 6-tioguanine monitoring in steroid-dependent patients with inflammatory bowel diseases receiving azathioprine.

  Alimentary pharmacology & therapeutics 20050401

• Genotyping of thiopurine methyltransferase using pyrosequencing.

  Biological & pharmaceutical bulletin 20050401

• Sudden onset of Multiple nevi after administration of 6-mercaptopurine in an adult with Crohn's disease: a case report.

  International journal of dermatology 20050401

• Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.

  Cancer cell 20050401

• Effects of 6-mercaptopurine treatment on sperm production and reproductive performance: a study in male mice.

  Scandinavian journal of gastroenterology 20050401

• A simple hybrid variance estimator for the Kaplan-Meier survival function.

  Statistics in medicine 20050330

• Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia.

  JAMA 20050323

• Portal hypertension develops in a subset of children with standard risk acute lymphoblastic leukemia treated with oral 6-thioguanine during maintenance therapy.

  Pediatric blood & cancer 20050301

• Infliximab efficacy in pediatric ulcerative colitis.

  Inflammatory bowel diseases 20050301

• Can we alter the natural history of Crohn disease in children?

  Journal of pediatric gastroenterology and nutrition 20050301

• Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects.

  European journal of cancer (Oxford, England : 1990) 20050301

• Measurement of thiopurine methyl transferase activity guides dose-initiation and prevents toxicity from azathioprine.

  The New Zealand medical journal 20050225

• Raman mapping and in situ SERS spectroelectrochemical studies of 6-mercaptopurine SAMs on the gold electrode.

  The journal of physical chemistry. B 20050224

• [Adolescents with acute lymphatic leukaemia achieve significantly better results when treated following Dutch paediatric oncology protocols than with adult protocols].

  Nederlands tijdschrift voor geneeskunde 20050219

• Explained randomness in proportional hazards models.

  Statistics in medicine 20050215

• Review article: monitoring of immunomodulators in inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20050215

• [Inflammatory bowel disease--diagnosis and therapy].

  Praxis 20050202

• Selective inhibition of inflammatory gene expression in activated T lymphocytes: a mechanism of immune suppression by thiopurines.

  The Journal of pharmacology and experimental therapeutics 20050201

• Mesenteric pulsatility index analysis predicts response to azathioprine in patients with Crohn's disease.

  Inflammatory bowel diseases 20050201

• Use of 6-mercaptopurine/azathioprine as the immunomodulator of choice for moderately active Crohn's disease: pro.

  Inflammatory bowel diseases 20050201

• Use of 6-mercapturine/azathioprine as the immunomodulator of choice for moderately active Crohn's disease: con.

  Inflammatory bowel diseases 20050201

• Use of 6-mercaptopurine/azathioprine as the immunomodulator of choice for moderately active Crohn's disease: balance.

  Inflammatory bowel diseases 20050201

• Hepatosplenic T-cell lymphoma in an adolescent patient after immunomodulator and biologic therapy for Crohn disease.

  Journal of pediatric gastroenterology and nutrition 20050201

• Cognitive changes in children treated for acute lymphoblastic leukemia with chemotherapy only according to the Pediatric Oncology Group 9605 protocol.

  Journal of child neurology 20050201

• Advanced-stage large-cell lymphoma in children and adolescents: results of a randomized trial incorporating intermediate-dose methotrexate and high-dose cytarabine in the maintenance phase of the APO regimen: a Pediatric Oncology Group phase III trial.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050120

• [Treatment results with ALL-BFM-95 protocol in children with acute lymphoblastic leukemia in Hungary].

  Orvosi hetilap 20050109

• The ten-year single-center experience with 6-mercaptopurine in the treatment of inflammatory bowel disease.

  Journal of clinical gastroenterology 20050101

• Pharmacology of drugs for hyperuricemia. Mechanisms, kinetics and interactions.

  Contributions to nephrology 20050101

• Azathioprine and 6 Mercaptopurine in postoperative maintenance of Crohn's disease remission: is no evidence of effect an evidence of no effect?

  Gastroenterology 20050101

• 6-Mercaptopurine and mesalamine for prevention of relapse after conservative surgery for Crohn's disease.

  Gastroenterology 20050101

• Pharmacokinetics following intraventricular administration of chemotherapy in patients with neoplastic meningitis.

  Clinical pharmacokinetics 20050101

• Long-term oral tacrolimus therapy in refractory to infliximab fistulizing Crohn's disease: a pilot study.

  Inflammatory bowel diseases 20050101

• Extraintestinal manifestations of Crohn's disease.

  Digestion 20050101

• Maintenance of remission in Crohn's disease.

  Digestion 20050101

• Pregnancy and Crohn's disease.

  Digestion 20050101

• Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5).

  Drug metabolism reviews 20050101

• Treatment of acute lymphocytic leukemia using zinc adjuvant with chemotherapy and radiation--a case history and hypothesis.

  Medical hypotheses 20050101

• 6-mercaptopurine in patients with inflammatory bowel disease and previous digestive intolerance of azathioprine.

  Scandinavian journal of gastroenterology 20050101

• Comprehensive screening of the thiopurine methyltransferase polymorphisms by denaturing high-performance liquid chromatography.

  Genetic testing 20050101

• [Evaluation of compliance through specific interviews: a prospective study of 73 children with acute lymphoblastic leukemia].

  Jornal de pediatria 20050101

• ATP-binding cassette (ABC) transporters in normal and pathological lung.

  Respiratory research 20050101

• Long-term outcome of ph-negative acute lymphoblastic leukaemia in adults: a single centre experience.

  Acta haematologica 20050101

• Folate system correlations in DNA microarray data.

  BMC cancer 20050101

• [Treatment of adult Berkitt-like lymphoma].

  Terapevticheskii arkhiv 20050101

• Effects of 6-mercaptopurine (6-MP) on histomorphometric parameters of the rat bones.

  Pharmacological reports : PR 20050101

• Economic implications of biological therapies for Crohn's disease: review of infliximab.

  PharmacoEconomics 20050101

• Treatment of acute promyelocytic leukemia: a single institution experience.

  Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion 20050101

• Digital drug discovery.

  Genome biology 20050101

• [Pellagra].

  Sante (Montrouge, France) 20050101

• Designing drugs.

  American heritage of invention & technology 20050101

• Nitrogen fertilizer recommendations for corn grown on soils amended with oily food waste.

  Journal of environmental quality 20050101

• Prognostic impact of age in children and adolescents with acute lymphoblastic leukemia: data from the trials ALL-BFM 86, 90, and 95.

  Klinische Padiatrie 20050101

• Nurr1 dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts.

  Journal of inflammation (London, England) 20050101

• [Treatment results of Langerhans cell histiocytosis with LSH II protocol].

  Casopis lekaru ceskych 20050101

• Electrochemical determination of 6-mercaptopurine at silver microdisk electrodes.

  Annali di chimica 20050101

• Impact of efalizumab on patient-reported outcomes in high-need psoriasis patients: results of the international, randomized, placebo-controlled Phase III Clinical Experience Acquired with Raptiva (CLEAR) trial [NCT00256139].

  BMC dermatology 20050101

• 6-mercaptopurine and daunorubicin double drug liposomes-preparation, drug-drug interaction and characterization.

  Journal of liposome research 20050101

• Medical therapy for ulcerative colitis: the state of the art and beyond.

  Current gastroenterology reports 20041201

• Advances in medical therapy for Crohn's disease.

  Current gastroenterology reports 20041201

• Childhood leukaemia: a relationship between intracellular 6-mercaptopurine metabolites and neutropenia. 1983.

  British journal of clinical pharmacology 20041201

• [Efficacy of modified BFM-90 regimen on children and adolescents with T cell lymphoblastic lymphoma: a report of 20 cases].

  Ai zheng = Aizheng = Chinese journal of cancer 20041201

• Azathioprine acts upon rat hepatocyte mitochondria and stress-activated protein kinases leading to necrosis: protective role of N-acetyl-L-cysteine.

  The Journal of pharmacology and experimental therapeutics 20041101

• Acute promyelocytic leukemia and HIV-1 infection: case report and review of the literature.

  American journal of hematology 20041101

• Reviewing the mechanism of action of thiopurine drugs: towards a new paradigm in clinical practice.

  Medical science monitor : international medical journal of experimental and clinical research 20041101

• Use of laboratory testing to guide 6-mercaptopurine/azathioprine therapy.

  Gastroenterology 20041101

• Monitoring of long-term thiopurine therapy among adults with inflammatory bowel disease.

  Scandinavian journal of gastroenterology 20041101

• [Primary study of relationship between serum level of VEGF and non-Hodgkin's lymphoma in children and adolescent patients].

  Ai zheng = Aizheng = Chinese journal of cancer 20041101

• Efficacy of conventional immunosuppressive drugs in IBD.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20041101

• Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis.

  European journal of gastroenterology & hepatology 20041101

• [Chronic inflammatory bowel diseases].

  Deutsche medizinische Wochenschrift (1946) 20041015

• Establishment and characterisation of a human carcinoma cell line with acquired resistance to Aplidin.

  British journal of cancer 20041004

• Ulcerative colitis: conservative management and long-term effects.

  Langenbeck's archives of surgery 20041001

• Common variable immunodeficiency and the gastrointestinal tract.

  Current gastroenterology reports 20041001

• Review article: the long-term management of ulcerative colitis.

  Alimentary pharmacology & therapeutics 20041001

• Review article: chronic active disease and maintaining remission in Crohn's disease.

  Alimentary pharmacology & therapeutics 20041001

• Review article: treatment of perianal fistulizing Crohn's disease.

  Alimentary pharmacology & therapeutics 20041001

• Sperm, sex, and 6-MP: the perception on conception.

  Gastroenterology 20041001

• [Methotrexate-induced interstitial pneumonitis in a child with acute lymphoblastic leukemia].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 20041001

• The clinical impact of thiopurine methyltransferase polymorphisms on thiopurine treatment.

  Nucleosides, nucleotides & nucleic acids 20041001

• Allele frequency of inosine triphosphate pyrophosphatase gene polymorphisms in a Japanese population.

  Nucleosides, nucleotides & nucleic acids 20041001

• Consequences of binding an S-adenosylmethionine analogue on the structure and dynamics of the thiopurine methyltransferase protein backbone.

  Biochemistry 20040928

• Azathioprine formulation optimizes metabolite profile in inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20040915

• Inflammatory bowel disease: management issues during pregnancy.

  Archives of gynecology and obstetrics 20040901

• Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis.

  Blood 20040901

• Diagnosis of 6 mercaptopurine hepatotoxicity post liver transplantation utilizing metabolite assays.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040901

• Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel disease.

  The American journal of surgical pathology 20040901

• Experience with the use of low-dose methotrexate for inflammatory bowel disease.

  European journal of gastroenterology & hepatology 20040901

• Improved HPLC methodology for monitoring thiopurine metabolites in patients on thiopurine therapy.

  Clinical biochemistry 20040901

• The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease.

  The American journal of gastroenterology 20040901

• Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20040901

• Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo: a 2-year trial.

  Gastroenterology 20040901

• The efficacy of azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in patients with Crohn's disease remains uncertain.

  Gastroenterology 20040901

• [Ulcerative colitis. Chronic active course].

  Zeitschrift fur Gastroenterologie 20040901

• [Ulcerative colitis. Maintenance therapy].

  Zeitschrift fur Gastroenterologie 20040901

• [Immunosuppressive therapy for inflammatory bowel disease: consensus by the Austrian working group on IBD].

  Zeitschrift fur Gastroenterologie 20040901

• Could immunosuppressive drugs reduce recurrence rate after second resection for Crohn disease?

  Inflammatory bowel diseases 20040901

• Acute sinusoidal obstruction syndrome after 6-thioguanine therapy for Crohn's disease.

  Inflammatory bowel diseases 20040901

• [Life-threatening adverse effects of pharmacologic antihyperuricemic therapy].

  Therapeutische Umschau. Revue therapeutique 20040901

• In vitro drug sensitivity and apoptosis induction in newly diagnosed pediatric acute lymphoblastic leukemia: correlation with overall survival.

  Pediatric hematology and oncology 20040901

• Drug therapy for ulcerative colitis.

  World journal of gastroenterology 20040815

• The fidelity of replication of the three-base-pair set adenine/thymine, hypoxanthine/cytosine and 6-thiopurine/5-methyl-2-pyrimidinone with T7 DNA polymerase.

  The Biochemical journal 20040801

• A comparison of red blood cell thiopurine metabolites in children with acute lymphoblastic leukemia who received oral mercaptopurine twice daily or once daily: a Pediatric Oncology Group study (now The Children's Oncology Group).

  Pediatric blood & cancer 20040801

• Clinical significance of azathioprine active metabolite concentrations in inflammatory bowel disease.

  Gut 20040801

• Synthesis and antiproliferative activity of 3-aryl-2-[1H(2H)-benzotriazol-1(2)-yl]acrylonitriles variously substituted: Part 4.

  Farmaco (Societa chimica italiana : 1989) 20040801

• Clinical and laboratory evaluation of compliance in acute lymphoblastic leukaemia.

  Archives of disease in childhood 20040801

• Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs.

  Journal of neurochemistry 20040801

• [A systematic review of the clinical effectiveness of azathioprine in patients with ulcerative colitis].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040801

• Thiopurine drug adverse effects in a population of New Zealand patients with inflammatory bowel disease.

  Pharmacoepidemiology and drug safety 20040801

• How effective are the usual treatments for Crohn's disease?

  Alimentary pharmacology & therapeutics 20040715

• Efficacy and safety of thiopurinic immunomodulators (azathioprine and mercaptopurine) in steroid-dependent ulcerative colitis.

  Alimentary pharmacology & therapeutics 20040715

• The benefit of induction chemotherapy in patients age > or = 75 years.

  Cancer 20040715

• Medical approaches and future options in chronic active ulcerative colitis.

  International journal of colorectal disease 20040701

• Some cases demonstrating the clinical usefulness of therapeutic drug monitoring in thiopurine-treated inflammatory bowel disease patients.

  European journal of gastroenterology & hepatology 20040701

• Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?

  Annals of clinical biochemistry 20040701

• Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease.

  Inflammatory bowel diseases 20040701

• Infliximab therapy in pediatric Crohn's pouchitis.

  Inflammatory bowel diseases 20040701

• [A study on inclusion complexes of cyclodextrin with three anticancer xanthines by fluorescence].

  Guang pu xue yu guang pu fen xi = Guang pu 20040701

• Using pharmacogenetics to improve drug safety and efficacy.

  JAMA 20040616

• High-dose melphalan and autotransplantation followed by post transplant maintenance chemotherapy for acute lymphoblastic leukemia in first remission.

  Bone marrow transplantation 20040601

• Pharmacokinetics of 6-mercaptopurine in patients with inflammatory bowel disease: implications for therapy.

  Therapeutic drug monitoring 20040601

• Frequency distribution of thiopurine S-methyltransferase activity in red blood cells of a healthy Japanese population.

  Therapeutic drug monitoring 20040601

• General principles of medical therapy of inflammatory bowel disease.

  Gastroenterology clinics of North America 20040601

• Treatment of inflammatory bowel disease with azathioprine and 6-mercaptopurine.

  Gastroenterology clinics of North America 20040601

• Medical management of severe ulcerative colitis.

  Gastroenterology clinics of North America 20040601

• Medical management of postoperative recurrence in Crohn's disease.

  Gastroenterology clinics of North America 20040601

• Medical management of the pregnant patient with inflammatory bowel disease.

  Gastroenterology clinics of North America 20040601

• Discordant erythrocyte sedimentation rate and C-reactive protein in children with inflammatory bowel disease taking azathioprine or 6-mercaptopurine.

  Journal of pediatric gastroenterology and nutrition 20040501

• Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3.

  Drug metabolism and disposition: the biological fate of chemicals 20040501

• An improved HPLC method for the quantitation of 6-mercaptopurine and its metabolites in red blood cells.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20040501

• Review article: The medical treatment of Crohn's perianal fistulas.

  Alimentary pharmacology & therapeutics 20040501

• Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20040501

• In vivo kinetics of micronuclei induction by bifunctional alkylating antineoplastics.

  Mutagenesis 20040501

• Toxic ingestion of 6-mercaptopurine by young siblings of pediatric oncology patients.

  The Journal of pediatrics 20040501

• Early postoperative complications are not increased in patients with Crohn's disease treated perioperatively with infliximab or immunosuppressive therapy.

  The American journal of gastroenterology 20040501

• Additional discussion on the safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study.

  Gastroenterology 20040501

• Pharmacogenetic determinants of outcome in acute lymphoblastic leukaemia.

  British journal of haematology 20040501

• Mycophenolate mofetil for the treatment of autoimmune hepatitis in patients refractory to standard therapy.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20040501

• Comprehensive analysis of risk factors associating with Hepatitis B virus (HBV) reactivation in cancer patients undergoing cytotoxic chemotherapy.

  British journal of cancer 20040405

• Methylated metabolites of 6-mercaptopurine are associated with hepatotoxicity.

  Clinical pharmacology and therapeutics 20040401

• Bone marrow necrosis in a patient with acute promyelocytic leukemia during re-induction therapy with arsenic trioxide.

  European journal of haematology 20040401

• The effect on the fetus of medications used to treat pregnant inflammatory bowel-disease patients.

  The American journal of gastroenterology 20040401

• Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy.

  Therapeutic drug monitoring 20040401

• Analytic aspects of monitoring therapy with thiopurine medications.

  Therapeutic drug monitoring 20040401

• The analysis of correlations between drug resistance and clinical/laboratory measures found in a group of children with all treated by ALL-BFM 90 protocol.

  Bulletin du cancer 20040401

• The risk of congenital abnormalities in children fathered by men treated with azathioprine or mercaptopurine before conception.

  Alimentary pharmacology & therapeutics 20040315

• A multiplexed allele-specific polymerase chain reaction assay for the detection of common thiopurine S-methyltransferase (TPMT) mutations.

  Clinica chimica acta; international journal of clinical chemistry 20040301

• Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National Cancer Institute's anticancer drug screen.

  Drug metabolism and disposition: the biological fate of chemicals 20040301

• Thiopurine S-methyltransferase polymorphisms: efficient screening method for patients considering taking thiopurine drugs.

  European journal of clinical pharmacology 20040301

• Enzyme-catalyzed activation of anticancer prodrugs.

  Pharmacological reviews 20040301

• A search for the optimal duration of treatment with 6-mercaptopurine for ulcerative colitis.

  The American journal of gastroenterology 20040301

• Toxicity of low dose azathioprine and 6-mercaptopurine in rat hepatocytes. Roles of xanthine oxidase and mitochondrial injury.

  Journal of hepatology 20040301

• Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).

  Pharmacogenetics 20040301

• 6-Mercaptopurine is effective in Crohn's disease without concomitant steroids.

  Inflammatory bowel diseases 20040301

• Pulmonary involvement in Crohn's disease report of a case and review of the literature.

  Inflammatory bowel diseases 20040301

• Pharmacogenetics and inflammatory bowel disease: progress and prospects.

  Inflammatory bowel diseases 20040301

• Effect of antimetabolite immunosuppressants on Flaviviridae, including hepatitis C virus.

  Transplantation 20040227

• Antagonist: Early surgical intervention in ulcerative colitis.

  Gut 20040201

• Healthy offspring in parents both receiving thiopurines.

  Gastroenterology 20040201

• Antitumor activity of sugar-modified cytosine nucleosides.

  Cancer science 20040201

• [Observation on treatment of post-remission acute myeloid leukemia patients by lingxiong piaoling powder and longchan cigu decoction].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040201

• Azathioprine transport through rat skin and its immunosuppressive effect.

  Die Pharmazie 20040201

• Prolonged remission of severe Crohn's disease after fever and leukopenia caused by 6-mercaptopurine.

  Digestive diseases and sciences 20040201

• Pharmacogenomics and IBD: TPMT and thiopurines.

  Inflammatory bowel diseases 20040201

• Ulcerative proctitis.

  Clinics in colon and rectal surgery 20040201

• Cancer pharmacogenetics.

  British journal of cancer 20040112

• Bone marrow stroma damage induced by chemotherapy for acute lymphoblastic leukemia in children.

  Pediatric research 20040101

• Relevance of thiopurine methyltransferase status in rheumatology patients receiving azathioprine.

  Rheumatology (Oxford, England) 20040101

• Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders. The impact of TPMT genotyping in predicting toxicity.

  European journal of clinical pharmacology 20040101

• Current therapy of ulcerative colitis in children.

  Expert opinion on pharmacotherapy 20040101

• Oral treatment of acute myeloid leukaemia with etoposide, thioguanine, and idarubicin (ETI) in elderly patients: a prospective randomised comparison with intravenous cytarabine, idarubicin, and thioguanine in the second and third treatment cycle.

  European journal of haematology 20040101

• Clinical utility of thiopurine S-methyltransferase genotyping.

  American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 20040101

• Two-day induction with thymoglobulin in kidney transplantation: risks and benefits.

  Transplantation proceedings 20040101

• Thiopurine methyltransferase activity in red blood cells of dogs.

  Journal of veterinary internal medicine 20040101

• Maintenance therapy in childhood acute myeloid leukemia.

  Annals of hematology 20040101

• Maintenance of remission in Crohn's disease: current and emerging therapeutic options.

  Drugs 20040101

• Unintentional intravenous infusion of Golytely in a 4-year-old girl.

  The Annals of pharmacotherapy 20040101

• [Genetic polymorphism and treatment of chronic bowel inflammatory diseases: the example of azathioprine].

  Therapie 20040101

• Acute lymphoblastic leukemia in infants.

  The Turkish journal of pediatrics 20040101

• Human red blood cells: rheological aspects, uptake, and release of cytotoxic drugs.

  Critical reviews in clinical laboratory sciences 20040101

• Metals and metal compounds in cancer treatment.

  Anticancer research 20040101

• All-transretinoic acid and chemotherapy in the treatment of acute promyelocytic leukemia.

  Indian journal of cancer 20040101

• PEG prodrugs of 6-mercaptopurine for parenteral administration using benzyl elimination of thiols.

  Oncology research 20040101

• [Immunotherapy of inflammatory bowel diseases].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20040101

• Management of ulcerative colitis and Crohn's disease.

  Acta clinica Belgica 20040101

• [Immunosupressants and MICI].

  Gastroenterologie clinique et biologique 20040101

• [Treatment results in children with standard-risk acute lymphoblastic leukemia. Report of the Polish Pediatric Leukemia/Lymphoma Study Group].

  Przeglad lekarski 20040101

• [Second neoplasm in a 13-year-old boy complicated by Crohn's disease. Case report].

  Medycyna wieku rozwojowego 20040101

• Reduction of drug toxicity using dendrimers based on melamine.

  Molecular pharmaceutics 20040101

• [Immunosuppressive therapy of inflammatory diseases of the large intestine].

  Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20040101

• Optimizing anti-tumor necrosis factor strategies in inflammatory bowel disease.

  Current gastroenterology reports 20031201

• Optimizing immunomodulator therapy for inflammatory bowel disease.

  Current gastroenterology reports 20031201

• Role of macrophages and stellate cells in the pathogenesis of veno-occlusive disease: an electron microscopic case study.

  Experimental and molecular pathology 20031201

• Study of ruthenium(II) complexes with anticancer drugs as ligands. Design of metal-based phototherapeutic agents.

  Inorganic chemistry 20031201

• Evidence-based treatment algorithm for mild to moderate Crohn's disease.

  The American journal of gastroenterology 20031201

• Maintenance therapy for inflammatory bowel disease.

  The American journal of gastroenterology 20031201

• Synthesis of base substituted 2-hydroxy-3-(purin-9-yl)-propanoic acids and 4-(purin-9-yl)-3-butenoic acids.

  Nucleosides, nucleotides & nucleic acids 20031201

• [Relationship between single nucleotide polymorphisms in thiopurine methyltransferase gene and tolerance to thiopurines in acute leukemia].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20031201

• Fistula response to methotrexate in Crohn's disease: a case series.

  Alimentary pharmacology & therapeutics 20031115

• Spectroscopy behavior of 6-Mercaptopurine, Azathiopurine, and 8-Azaguanine.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20031101

• Predictive factors of response of perianal Crohn's disease to azathioprine or 6-mercaptopurine.

  Diseases of the colon and rectum 20031101

• Protein expression of the glucocorticoid receptor in childhood acute lymphoblastic leukemia.

  Haematologica 20031101

• Discussion on the safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study.

  Gastroenterology 20031101

• Monitoring of AZA/6-MP treatment in children with IBD is necessary.

  Inflammatory bowel diseases 20031101

• Monitoring of azathioprine/6-mercaptopurine treatment in children with IBD is not necessary.

  Inflammatory bowel diseases 20031101

• 6TG: when less is more than you bargained for.

  Inflammatory bowel diseases 20031101

• A novel Escherichia coli strain allows functional analysis of guanylate kinase drug resistance and sensitivity.

  Analytical biochemistry 20031101

• High-performance liquid chromatographic assay of metabolites of thioguanine and mercaptopurine in capillary blood.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031025

• Tertiary structure of thiopurine methyltransferase from Pseudomonas syringae, a bacterial orthologue of a polymorphic, drug-metabolizing enzyme.

  Journal of molecular biology 20031024

• Preventing toxicity with a gene test.

  Science (New York, N.Y.) 20031024

• Drug methylation in cancer therapy: lessons from the TPMT polymorphism.

  Oncogene 20031020

• Thioguanine offers no advantage over mercaptopurine in maintenance treatment of childhood ALL: results of the randomized trial COALL-92.

  Blood 20031015

• Determination of thiopurine methyltransferase phenotype in isolated human erythrocytes using a new simple nonradioactive HPLC method.

  Therapeutic drug monitoring 20031001

• Veno-occlusive disease in patients receiving thiopurines during maintenance therapy for childhood acute lymphoblastic leukaemia.

  British journal of haematology 20031001

• Childhood T-cell acute lymphoblastic leukemia: the Dana-Farber Cancer Institute acute lymphoblastic leukemia consortium experience.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20031001

• [Juvenile myelomonocytic leukaemia, xanthoma, and neurofibromatosis type 1].

  Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20031001

• Choice of chemotherapy in induction, consolidation and maintenance in acute promyelocytic leukaemia.

  Best practice & research. Clinical haematology 20030901

• Treatment of older adults with acute promyelocytic leukaemia.

  Best practice & research. Clinical haematology 20030901

• Cumulative experience with short- and long-term toxicity to 6-mercaptopurine in the treatment of Crohn's disease and ulcerative colitis.

  Journal of clinical gastroenterology 20030901

• Thiopurine S-methyltransferase pharmacogenetics: chaperone protein association and allozyme degradation.

  Pharmacogenetics 20030901

• [Acute myeloid leukemia originating from the same leukemia clone after the complete remission of acute lymphoid leukemia].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 20030901

• Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20030815

• Tioguanine in patients with Crohn's disease intolerant or resistant to azathioprine/mercaptopurine.

  Alimentary pharmacology & therapeutics 20030815

• Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia.

  International journal of oncology 20030801

• Msh2 deficiency attenuates but does not abolish thiopurine hematopoietic toxicity in msh2-/- mice.

  Molecular pharmacology 20030801

• Leflunomide treatment of Crohn's disease patients intolerant to standard immunomodulator therapy.

  Journal of clinical gastroenterology 20030801

• Myelodysplastic syndrome after acute promyelocytic leukemia: the European APL group experience.

  Leukemia 20030801

• Corticosteroids and immunomodulators: postoperative infectious complication risk in inflammatory bowel disease patients.

  Gastroenterology 20030801

• 6-mercaptopurine beats a bum rap.

  Gastroenterology 20030801

• Amperometric determination of 6-mercaptopurine on functionalized multi-wall carbon nanotubes modified electrode by liquid chromatography coupled with microdialysis and its application to pharmacokinetics in rabbit.

  Talanta 20030727

• High variation of tioguanine absorption in patients with chronic active Crohn's disease.

  Alimentary pharmacology & therapeutics 20030715

• Study of the interaction of 6-mercaptopurine with protein by microdialysis coupled with LC and electrochemical detection based on functionalized multi-wall carbon nanotubes modified electrode.

  Journal of pharmaceutical and biomedical analysis 20030714

• The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine.

  The Journal of biological chemistry 20030704

• Identification of the antineoplastic agent 6-mercaptopurine as an activator of the orphan nuclear hormone receptor Nurr1.

  The Journal of biological chemistry 20030704

• Real-time RT-PCR methodology for quantification of thiopurine methyltransferase gene expression.

  European journal of clinical pharmacology 20030701

• Severe gastrointestinal illness associated with olestra ingestion.

  Journal of pediatric gastroenterology and nutrition 20030701

• Dose reduction of coadministered 6-mercaptopurine decreases myelotoxicity following high-dose methotrexate in childhood leukemia.

  Leukemia 20030701

• A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL.

  Leukemia 20030701

• [Molecular mechanisms of drug influx and efflux transport at the blood-brain barrier].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030701

• Severe isolated Crohn's-like disease of the gastroduodenal tract.

  Digestive diseases and sciences 20030701

• Genetic polymorphism of thiopurine S-methyltransferase in Argentina.

  Annals of clinical biochemistry 20030701

• Erythrocyte mean corpuscular volume as a surrogate marker for 6-thioguanine nucleotide concentration monitoring in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine.

  Inflammatory bowel diseases 20030701

• [Thiopurine methyltransferase activity and myelosuppression in inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine].

  Medicina clinica 20030607

• Hypersensitivity reactions to chemotherapeutic drugs.

  Clinical reviews in allergy & immunology 20030601

• Distinct tissue distribution of metabolites of the novel glutathione-activated thiopurine prodrugs cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)guanine and 6-thioguanine in the mouse.

  Drug metabolism and disposition: the biological fate of chemicals 20030601

• Review article: medical treatment of moderate to severe Crohn's disease.

  Alimentary pharmacology & therapeutics 20030601

• Review article: maintenance treatment of Crohn's disease.

  Alimentary pharmacology & therapeutics 20030601

• Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia.

  Clinical pharmacology and therapeutics 20030601

• Long-term survival in acute lymphoblastic leukaemia in adults treated according to the LALA 87 protocol.

  Chemotherapy 20030601

• Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group.

  Blood 20030515

• The role of multidrug resistance protein 1 (MRP1) in transport of fluorescent anions across the human erythrocyte membrane.

  The Journal of membrane biology 20030515

• Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells.

  Nature genetics 20030501

• On-line monitoring of airborne chemistry in levitated nanodroplets: in situ synthesis and application of SERS-active Ag-Sols for trace analysis by FT-Raman spectroscopy.

  Analytical chemistry 20030501

• 6-mercaptopurine and inflammatory bowel disease: hidden ground for the cytomegalovirus.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20030501

• Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine.

  The American journal of gastroenterology 20030501

• [Auto-immune hepatitis: therapeutic management].

  Gastroenterologie clinique et biologique 20030501

• CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes.

  The Journal of clinical investigation 20030415

• Complications of pregnancy and child development after cessation of treatment with 6-mercaptopurine for inflammatory bowel disease.

  Journal of clinical gastroenterology 20030401

• Second malignant neoplasms after treatment of childhood cancer.

  European journal of cancer (Oxford, England : 1990) 20030401

• Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030401

• Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20030401

• Topical delivery of 5-fluorouracil and 6-mercaptopurine by their alkylcarbonyloxymethyl prodrugs from water: vehicle effects on design of prodrugs.

  Pharmaceutical research 20030401

• Cancer pharmacogenomics: current and future applications.

  Biochimica et biophysica acta 20030317

• Azathioprine, mercaptopurine and birth outcome: a population-based cohort study.

  Alimentary pharmacology & therapeutics 20030315

• Cytotoxic activity of 6-alkynyl- and 6-alkenylpurines.

  Bioorganic & medicinal chemistry letters 20030310

• Cell proliferation is related to in vitro drug resistance in childhood acute leukaemia.

  British journal of cancer 20030310

• High survival rate in childhood non-Hodgkin lymphoma without CNS involvement: results of BFM 95 study in Kuwait.

  Pediatric hematology and oncology 20030301

• Benign intracranial hypertension in association with acute lymphoblastic leukemia.

  Pediatric hematology and oncology 20030301

• Hepatotoxicity associated with 6-thioguanine therapy for Crohn's disease.

  Journal of clinical gastroenterology 20030301

• Recent advances in immunomodulation in the treatment of inflammatory bowel disease.

  European journal of gastroenterology & hepatology 20030301

• Thiopurine therapy: when to start and when to stop.

  European journal of gastroenterology & hepatology 20030301

• Ciclosporin and refractory colitis.

  European journal of gastroenterology & hepatology 20030301

• Successful reintroduction of methotrexate after acute pneumonitis in a patient with acute lymphoblastic leukemia.

  Annals of hematology 20030301

• Treatment of recurrent eosinophilic granuloma with systemic therapy.

  Ophthalmic plastic and reconstructive surgery 20030301

• First experience with intracytoplasmic sperm injection for extreme oligozoospermia associated with Crohn's disease and 6-mercaptopurine chemotherapy.

  Asian journal of andrology 20030301

• Low dose methotrexate in inflammatory bowel disease: current status and future directions.

  The American journal of gastroenterology 20030301

• Immunomodulators and 'on demand' therapy with infliximab in Crohn's disease: clinical experience with 400 infusions.

  The American journal of gastroenterology 20030301

• [Management of ulcerative colitis].

  Therapeutische Umschau. Revue therapeutique 20030301

• Comparison of suppressive potency between azathioprine and 6-mercaptopurine against mitogen-induced blastogenesis of human peripheral blood mononuclear cells in-vitro.

  The Journal of pharmacy and pharmacology 20030301

• Position statement: immunomodulator therapy for inflammatory Bowel disease.

  The Israel Medical Association journal : IMAJ 20030301

• [Therapy of chronic inflammatory bowel diseases with azathioprine, 6-mercaptopurine and 6-thioguanine. Clinico-pharmacologic aspects].

  Deutsche medizinische Wochenschrift (1946) 20030221

• 6-thioguanine--efficacy and safety in chronic active Crohn's disease.

  Alimentary pharmacology & therapeutics 20030215

• Effective drug delivery by PEGylated drug conjugates.

  Advanced drug delivery reviews 20030210

• Cyclosporin for refractory ulcerative colitis.

  Gut 20030201

• Diminished anticoagulant effects of warfarin with concomitant mercaptopurine therapy.

  Pharmacotherapy 20030201

• Optimizing treatment with thioguanine derivatives in inflammatory bowel disease.

  Best practice & research. Clinical gastroenterology 20030201

• Safe treatment of thiopurine S-methyltransferase deficient Crohn's disease patients with azathioprine.

  Gut 20030101

• Dental abnormalities in children after chemotherapy treatment for acute lymphoid leukemia.

  Leukemia research 20030101

• Unlicensed and off label drug use in acute lymphoblastic leukaemia and other malignancies in children.

  Annals of oncology : official journal of the European Society for Medical Oncology 20030101

• Review article: immunopathogenetic and therapeutic aspects of autoimmune hepatitis.

  Alimentary pharmacology & therapeutics 20030101

• Mercaptopurine metabolite results in clinical gastroenterology practice.

  Alimentary pharmacology & therapeutics 20030101

• Is thiopurine methyltransferase genetic polymorphism a major factor for withdrawal of azathioprine in rheumatoid arthritis patients?

  Rheumatology (Oxford, England) 20030101

• The safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study.

  Gastroenterology 20030101

• Application of pharmacokinetic/pharmacodynamic and stochastic modelling to 6-mercaptopurine micronucleus induction in mouse bone marrow erythrocytes.

  Journal of applied toxicology : JAT 20030101

• [Invasive cancer of the cervix in a patient undergoing chronic treatment with 6-mercaptopurine for Crohns disease].

  Gastroenterologia y hepatologia 20030101

• Azathioprine and anti-TNF alpha therapies in Crohn's disease: a review of pharmacology, clinical efficacy and safety.

  Pharmacological research 20030101

• [Acute episode].

  Zeitschrift fur Gastroenterologie 20030101

• [Chronically active Crohn's disease].

  Zeitschrift fur Gastroenterologie 20030101

• [Maintaining a remission].

  Zeitschrift fur Gastroenterologie 20030101

• Combination therapy in childhood leukaemia: in vitro studies of thiopurines and inhibitors of purine metabolism on apoptosis.

  Annals of clinical biochemistry 20030101

• Measurement of thiopurine S-methyltransferase activity in human blood samples based on high-performance liquid chromatography: reference values in erythrocytes from children.

  Annals of clinical biochemistry 20030101

• 6-Thioguanine seems promising in azathioprine- or 6-mercaptopurine-intolerant inflammatory bowel disease patients: a short-term safety assessment.

  European journal of gastroenterology & hepatology 20030101

• [Inflammatory bowel diseases (IBD) -- critical discussion of etiology, pathogenesis, diagnostics, and therapy].

  Der Radiologe 20030101

• Investigation of the mechanisms of therapy-related hypoglycaemia in children with acute lymphoblastic leukaemia.

  Acta paediatrica (Oslo, Norway : 1992) 20030101

• Treatment of inflammatory bowel disease in childhood: best available evidence.

  Inflammatory bowel diseases 20030101

• [Significance of TPMT activity and TGNs level detection for individualizing 6-mercaptopurine chemotherapy].

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20030101

• Therapeutic efficacy and safety of 6-mercaptopurine and azathioprine in patients with Crohn's disease.

  Reviews in gastroenterological disorders 20030101

• Clinical use and practical application of TPMT enzyme and 6-mercaptopurine metabolite monitoring in IBD.

  Reviews in gastroenterological disorders 20030101

• Optimizing the therapeutic potential of azathioprine/6-mercaptopurine in the treatment of inflammatory bowel disease.

  Journal of clinical gastroenterology 20030101

• Utility of measuring 6-methylmercaptopurine and 6-thioguanine nucleotide levels in managing inflammatory bowel disease patients treated with 6-mercaptopurine in a clinical practice setting.

  Journal of clinical gastroenterology 20030101

• The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 5'-nucleotidase.

  BMC biochemistry 20030101

• Optimization and individualization of thiopurine therapy in inflammatory bowel disease: the great variability among drug responses.

  The pharmacogenomics journal 20030101

• Cytokine and anti-cytokine therapies for inflammatory bowel disease.

  Current pharmaceutical design 20030101

• The state of the art in the management of inflammatory bowel disease.

  Reviews in gastroenterological disorders 20030101

• A national survey on the patterns of treatment of inflammatory bowel disease in Canada.

  BMC gastroenterology 20030101

• [Does conservative therapy of chronic inflammatory bowel diseases still play a role?].

  Swiss surgery = Schweizer Chirurgie = Chirurgie suisse = Chirurgia svizzera 20030101

• Wegener's granulomatosis: current and upcoming therapies.

  Arthritis research & therapy 20030101

• [The assessment of plasma levels of insulin-like growth factor (IGF-I) and binding protein (IGFBP-3) during the maintenance therapy and after remissionof acute lymphoblastic leukemia (ALL)].

  Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych 20030101

• [The influence of age, gender and modifications of therapeutic protocols on physical development of children and adolescents after completion of therapy for acute lymphoblastic leukemia].

  Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych 20030101

• A case of leukemia of the appendix presenting as acute appendicitis.

  Acta haematologica 20030101

• Laparoscopic management of complex Crohn's disease.

  JSLS : Journal of the Society of Laparoendoscopic Surgeons 20030101

• Role of red blood cells in pharmacokinetics of chemotherapeutic agents.

  Clinical pharmacokinetics 20030101

• Comparison of the effects of azathioprine and its novel non-mercaptopurine analog on antibody response in rabbits.

  Polish journal of pharmacology 20030101

• Allelic variants of the thiopurine methyltransferase (TPMT) gene in the Colombian population.

  Methods and findings in experimental and clinical pharmacology 20030101

• Pharmacogenomics of azathioprine and 6-mercaptopurine in gastroenterologic therapy.

  Reviews in gastroenterological disorders 20030101

• Low-dose azathioprine is effective and safe for maintenance of remission in patients with ulcerative colitis.

  Journal of gastroenterology 20030101

• Role and side-effects of TPMT polymorphisms of 6-MP and azathioprine in the treatment of steroid-resistant and -dependent ulcerative colitis.

  Journal of gastroenterology 20030101

• [Improved results in children with acute lymphoblastic leukemia treated with the ALL-BFM 90 protocol in the Czech Republic].

  Casopis lekaru ceskych 20030101

• Thioguanine, mercaptopurine: their analogs and nucleosides as antimetabolites.

  Current pharmaceutical design 20030101

• Cancer pharmacogenomics: SNPs, chips, and the individual patient.

  Cancer investigation 20030101

• Standard treatment of ulcerative colitis.

  Digestive diseases (Basel, Switzerland) 20030101

• Pediatric acute lymphoblastic leukemia.

  Hematology. American Society of Hematology. Education Program 20030101

• Azathioprine as a treatment for severe atopic eczema in children with a partial thiopurine methyl transferase (TPMT) deficiency.

  Pediatric dermatology 20030101

• Bioequivalence of azathioprine products.

  Reviews in gastroenterological disorders 20030101

• Comparative kinetics of azathioprine and metazathioprine mercaptolysis in presence of physiological thiols.

  Acta poloniae pharmaceutica 20030101

• Safety of thiopurines in the treatment of inflammatory bowel disease.

  Scandinavian journal of gastroenterology. Supplement 20030101

• [Efficacy of medical therapy in preventing the post-surgical recurrence in Crohn's disease].

  Annali italiani di chirurgia 20030101

• [Conservative therapy of inflammatory bowel diseases].

  Orvosi hetilap 20021215

• Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells.

  Molecular pharmacology 20021201

• Evolving medical therapies for ulcerative colitis.

  Current gastroenterology reports 20021201

• Advances in medical therapy for Crohn's disease.

  Current gastroenterology reports 20021201

• Infliximab in the treatment of Crohn's disease: a user's guide for clinicians.

  The American journal of gastroenterology 20021201

• Induction therapy with idarubicin alone significantly influences event-free survival duration in patients with newly diagnosed hypergranular acute promyelocytic leukemia: final results of the GIMEMA randomized study LAP 0389 with 7 years of minimal follow-up.

  Blood 20021101

• Improvement over time in outcome for children with acute lymphoblastic leukemia in second remission given hematopoietic stem cell transplantation from unrelated donors.

  Leukemia 20021101

• Appendectomy protects against the development of ulcerative colitis but does not affect its course.

  The American journal of gastroenterology 20021101

• Inhibitors of de novo nucleotide biosynthesis as drugs.

  Accounts of chemical research 20021101

• Methotrexate polyglutamation may lack prognostic significance in children with B-cell precursor acute lymphoblastic leukemia treated with intensive oral methotrexate.

  Journal of pediatric hematology/oncology 20021101

• Severe pancytopenia from thiopurine methyltransferase deficiency: a preventable complication of 6-mercaptopurine therapy in children with Crohn disease.

  Journal of pediatric gastroenterology and nutrition 20021101

• The glutathione-activated thiopurine prodrugs trans-6-(2-acetylvinylthio)guanine and cis-6-(2-acetylvinylthio)purine cause less in vivo toxicity than 6-thioguanine after single- and multiple-dose regimens.

  Molecular cancer therapeutics 20021101

• Recent developments in inflammatory bowel disease.

  The Medical clinics of North America 20021101

• Oral cancer treatment: developments in chemotherapy and beyond.

  British journal of cancer 20021021

• [Resistance to tumor specific therapy with imatinib by clonal selection of mutated cells].

  Deutsche medizinische Wochenschrift (1946) 20021018

• Drug side-effects in IBD.

  Alimentary pharmacology & therapeutics 20021001

• Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain.

  Journal of neurochemistry 20021001

• [Individualized therapy with azathioprine or 6-mercaptopurine by monitoring thiopurine methyl-transferase (TPMT) activity].

  Revista clinica espanola 20021001

• [Pharmacogenetic study of thiopurine S-methyltransferase (TPMT) and thiopurine toxicity].

  Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 20021001

• Determination of thiols in urinary sample by capillary-column liquid chromatography with amperometric detection at a carbon electrode.

  Talanta 20020912

• Loss of heterozygosity of p16 correlates with minimal residual disease at the end of the induction therapy in non-high risk childhood B-cell precursor acute lymphoblastic leukemia.

  Leukemia research 20020901

• Thiopurine S-methyltransferase activity in Japanese subjects: metabolic activity of 6-mercaptopurine 6-methylation in different TPMT genotypes.

  Clinica chimica acta; international journal of clinical chemistry 20020901

• The role of posttransplantation maintenance chemotherapy in improving the outcome of autotransplantation in adult acute lymphoblastic leukemia.

  Blood 20020901

• Therapy-related myelodysplastic syndrome or acute myelogenous leukemia in patients with acute promyelocytic leukemia (APL).

  Leukemia 20020901

• Simple chemiluminescence method for the determination of mercaptopurine.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20020901

• Spectrophotometric determination of biologically active thiols with eosin, silver(I) and adenine.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20020901

• 6-Mercaptopurine teratogenicity.

  Postgraduate medical journal 20020901

• Biologic and molecular mechanisms for sex differences in pharmacokinetics, pharmacodynamics, and pharmacogenetics: Part I.

  Journal of women's health & gender-based medicine 20020901

• Azathioprine or 6-mercaptopurine before colectomy for ulcerative colitis is not associated with increased postoperative complications.

  Inflammatory bowel diseases 20020901

• Ex vivo drug resistance profile in childhood acute myelogenous leukemia: no drug is more effective in comparison to acute lymphoblastic leukemia.

  Leukemia & lymphoma 20020901

• Use of the photo-micronucleus assay in Chinese hamster V79 cells to study photochemical genotoxicity.

  Mutation research 20020826

• De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo.

  Blood 20020815

• TPMT in the treatment of Crohn's disease with azathioprine.

  Gut 20020801

• Protagonist: Crohn's disease recurrence can be prevented after ileal resection.

  Gut 20020801

• Immunosuppressants and operation in ulcerative colitis.

  Journal of the American College of Surgeons 20020801

• Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism.

  Pharmacogenetics 20020801

• Combining infliximab with 6-mercaptopurine/azathioprine for fistula therapy in Crohn's disease.

  The American journal of gastroenterology 20020801

• [Progress in the field of hematology in the last 100 years: Medical history of acute leukemia].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20020710

• CD56 expression predicts occurrence of CNS disease in acute lymphoblastic leukemia.

  Leukemia research 20020701

• Review article: treatment of mild to moderate ulcerative colitis and pouchitis.

  Alimentary pharmacology & therapeutics 20020701

• Review article: maintenance of remission in ulcerative colitis.

  Alimentary pharmacology & therapeutics 20020701

• Review article: the management of refractory Crohn's disease.

  Alimentary pharmacology & therapeutics 20020701

• The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs.

  Molecular pharmacology 20020701

• Leucocyte versus erythrocyte thioguanine nucleotide concentrations in children taking thiopurines for acute lymphoblastic leukaemia.

  Cancer chemotherapy and pharmacology 20020701

• Symptomatic hypoglycemia in children receiving oral purine analogues for treatment of childhood acute lymphoblastic leukemia.

  Medical and pediatric oncology 20020701

• Variant translocations of 11q23 in infant acute lymphoblastic leukemia (ALL): do outcomes differ from t(4;11)?

  Medical and pediatric oncology 20020701

• Increased factor VIII activity and dural sinus thrombosis.

  Medical and pediatric oncology 20020701

• Infliximab improves quality of life in patients with Crohn's disease.

  Inflammatory bowel diseases 20020701

• Corticosteroid-sparing treatments in patients with Crohn's disease.

  The American journal of gastroenterology 20020701

• [Development of simplified and rapid detection assay for genetic polymorphisms influencing drug response and its clinical applications].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20020701

• Advances in the medical therapy of inflammatory bowel disease.

  Current opinion in gastroenterology 20020701

• Thiopurine methyltransferase activity: new conditions for reversed-phase high-performance liquid chromatographic assay without extraction and genotypic-phenotypic correlation.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020625

• Impact of addition of maintenance therapy to intensive induction and consolidation chemotherapy for childhood acute myeloblastic leukemia: results of a prospective randomized trial, LAME 89/91. Leucámie Aiqüe Myéloïde Enfant.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020615

• Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: possible role of concomitant methotrexate.

  Therapeutic drug monitoring 20020601

• BFM-oriented treatment for children with acute lymphoblastic leukemia without cranial irradiation and treatment reduction for standard risk patients: results of DCLSG protocol ALL-8 (1991-1996).

  Leukemia 20020601

• Recurrence of Langerhans cell histiocytosis in the graft after liver transplantation in adults.

  Transplantation proceedings 20020601

• Forecast for using metabolite measurements in the dosing of azathioprine or 6-mercaptopurine for IBD patients: 'partly cloudy'.

  Gastroenterology 20020601

• Cytotoxic effects of 27 anticancer drugs in HeLa and MDR1-overexpressing derivative cell lines.

  Biological & pharmaceutical bulletin 20020601

• [When is drug therapy with azathioprine indicated in Crohn's disease?].

  Deutsche medizinische Wochenschrift (1946) 20020531

• Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemia.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020515

• Review article: is clinical remission the optimum therapeutic goal in the treatment of Crohn's disease?

  Alimentary pharmacology & therapeutics 20020501

• Teratogen update: azathioprine and 6-mercaptopurine.

  Teratology 20020501

• Modulation of colony stimulating factor release and apoptosis in human colon cancer cells by anticancer drugs.

  British journal of cancer 20020422

• Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice.

  The Journal of pharmacology and experimental therapeutics 20020401

• 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.

  Gastroenterology 20020401

• Review article: monitoring for drug side-effects in inflammatory bowel disease.

  Alimentary pharmacology & therapeutics 20020401

• Determination of thiopurine S-methyltransferase phenotype using thin-layer chromatography and quantitative scanning.

  European journal of clinical pharmacology 20020401

• Burkitt's lymphoma: single-centre experience with modified BFM protocol.

  Clinical and laboratory haematology 20020401

• Immunomodulatory therapy for pediatric inflammatory bowel disease: changing patterns of use, 1990-2000.

  The American journal of gastroenterology 20020401

• The role of drug efflux pumps in acute myeloid leukemia.

  Leukemia & lymphoma 20020401

• Management of internal fistulas in Crohn's disease.

  Inflammatory bowel diseases 20020301

• The Children Leukemia Group: 30 years of research and achievements.

  European journal of cancer (Oxford, England : 1990) 20020301

• Randomized, controlled trial of recombinant human interleukin-11 in patients with active Crohn's disease.

  Alimentary pharmacology & therapeutics 20020301

• Pharmacological characterization of the ATP-dependent low K(m) guanosine 3',5'-cyclic monophosphate (cGMP) transporter in human erythrocytes.

  Biochemical pharmacology 20020301

• [Treatment of acute lymphoblastic leukemia in adults with seven-drug induction therapy and intensive consolidation with or without autologous stem cell transplantation followed by maintenance therapy. Experience of a single center].

  Casopis lekaru ceskych 20020301

• Successful treatment of postoperative pyoderma gangrenosum with cyclosporin.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20020301

• Inflammatory bowel disease in the pediatric and adolescent patient.

  Gastroenterology clinics of North America 20020301

• Cytotoxic and antibacterial activity of 2-oxopurine derivatives.

  Bioorganic & medicinal chemistry letters 20020225

• Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia: increased early death after chemotherapy.

  Leukemia 20020201

• Effect of methotrexate polyglutamates on thioguanine nucleotide concentrations during continuation therapy of acute lymphoblastic leukemia with mercaptopurine.

  Leukemia 20020201

• Review article: Immunosuppressants in distal ulcerative colitis.

  Alimentary pharmacology & therapeutics 20020201

• No major cognitive impairment in young children with acute lymphoblastic leukemia using chemotherapy only: a prospective longitudinal study.

  Journal of pediatric hematology/oncology 20020201

• HPLC determination of thiopurine nucleosides and nucleotides in vivo in lymphoblasts following mercaptopurine therapy.

  Clinical chemistry 20020101

• Management of growth retardation in the young patient with Crohn's disease.

  Expert opinion on pharmacotherapy 20020101

• Epstein-Barr virus-positive lymphoma in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine.

  Gastroenterology 20020101

• Recurrent mercaptopurine-induced acute pancreatitis: a rare complication of chemotherapy for acute lymphoblastic leukemia in children.

  Medical and pediatric oncology 20020101

• Prognosis of elderly patients with acute myelogenous leukemia: analysis of 126 AML cases.

  International journal of hematology 20020101

• Philadelphia chromosome-positive acute myeloid leukemia with tetraploidy.

  International journal of hematology 20020101

• Results of a randomized phase III trial in children and adolescents with advanced stage diffuse large cell non-Hodgkin's lymphoma: a Pediatric Oncology Group study.

  Leukemia & lymphoma 20020101

• Pentasomy 8q resulting from duplication of isochromosome 8q in chronic myelomonocytic leukemia.

  Leukemia & lymphoma 20020101

• The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics.

  Pharmacogenomics 20020101

• Pharmacogenetics: has it reached the clinic?

  The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 20020101

• Intermediate-dose methotrexate and intravenous 6-mercaptopurine chemotherapy for children with acute lymphoblastic leukemia who did not respond to initial induction therapy.

  Journal of pediatric hematology/oncology 20020101

• Do immunosuppressants really work as maintenance therapy after the achievement of remission of severe ulcerative colitis?

  Journal of gastroenterology 20020101

• [Questions and answers on the role of azathioprine and 6-mercaptopurine in the treatment of inflammatory bowel disease].

  Gastroenterologia y hepatologia 20020101

• Food-drug interactions.

  Drugs 20020101

• Treatment of inflammatory bowel disease in the elderly: an update.

  Drugs & aging 20020101

• Comparative tolerability of therapies for ulcerative colitis.

  Drug safety 20020101

• Thiopurine methyltransferase polymorphisms in a multiracial asian population and children with acute lymphoblastic leukemia.

  Journal of pediatric hematology/oncology 20020101

• CD7+ and CD56+ myeloid/natural killer cell precursor acute leukemia treated with idarubicin and cytosine arabinoside.

  Acta haematologica 20020101

• Immunosuppressive treatment of Crohn's disease with fistulae.

  Bratislavske lekarske listy 20020101

• Ulcerative colitis in children: medical management.

  Paediatric drugs 20020101

• Preconcentration and separation of copper, zinc and cadmium by the use of 6-mercapto purinylazo resin and their application in microwave digested certified biological samples followed by AAS determination of the metal ions.

  Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20020101

• [Results of the treatment of childhood acute lymphoblastic leukemia according to the Berlin-Moscow-91 protocol in 1991-2000].

  Voprosy onkologii 20020101

• The combined effects of antibacterial peptide cecropin A and anti-cancer agents on leukemia cells.

  Anticancer research 20020101

• Evolving medical therapies for ulcerative colitis.

  Current gastroenterology reports 20011201

• Comparative pharmacokinetics of oral 6-mercaptopurine and intravenous 6-mercaptopurine riboside in children.

  Pediatrics international : official journal of the Japan Pediatric Society 20011201

• Mechanism of azathioprine-induced injury to hepatocytes: roles of glutathione depletion and mitochondrial injury.

  Journal of hepatology 20011201

• Why measure thiopurine methyltransferase activity? Direct administration of 6-thioguanine might be the alternative for 6-mercaptopurine or azathioprine.

  Gut 20011201

• Avoidance of steroids by the early use of infliximab and 6-mercaptopurine in an adolescent with active Crohn's colitis.

  The American journal of gastroenterology 20011201

• Randomized, double-blind, crossover, placebo-controlled trial of intravenous ondansetron for the prevention of intrathecal chemotherapy-induced vomiting in children.

  Journal of pediatric hematology/oncology 20011201

• Successful treatment of refractory Langerhans cell histiocytosis with unrelated cord blood transplantation.

  Journal of pediatric hematology/oncology 20011201

• Unrelated cord blood transplantation for an infant with chemotherapy-resistant progressive Langerhans cell histiocytosis.

  Journal of pediatric hematology/oncology 20011201

• Continuing therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of methotrexate, 6-mercaptopurine and 6-thioguanine.

  Cancer treatment reviews 20011201

• Diagnosis and treatment of perianal fistulas in Crohn disease.

  Annals of internal medicine 20011120

• In vitro bioassays for anticancer drug screening: effects of cell concentration and other assay parameters on growth inhibitory activity.

  Cancer letters 20011108

• Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide.

  Gut 20011101

• Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease.

  Gut 20011101

• Azathioprine treatment and male fertility in inflammatory bowel disease.

  Gastroenterology 20011101

• Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine.

  Leukemia 20011101

• Pitfalls in the determination of mutant alleles of the thiopurine methyltransferase gene.

  Leukemia 20011101

• Review article: the treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprine.

  Alimentary pharmacology & therapeutics 20011101

• Azathioprine for prevention of postoperative recurrence in Crohn's disease.

  European journal of gastroenterology & hepatology 20011101

• Management of fistulas in patients with Crohn's disease: antibiotic to antibody.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20011101

• Cytostatic activity of Achillea ageratum L.

  Phytotherapy research : PTR 20011101

• Langerhans cell histiocytosis.

  The Australasian journal of dermatology 20011101

• Review article: the limitations of corticosteroid therapy in Crohn's disease.

  Alimentary pharmacology & therapeutics 20011001

• Determination of thiopurine methyltransferase activity in human erythrocytes by high-performance liquid chromatography: comparison with the radiochemical method.

  Therapeutic drug monitoring 20011001

• 6-mercaptopurine metabolite levels in children with inflammatory bowel disease.

  Journal of pediatric gastroenterology and nutrition 20011001

• A variant form of acute promyelocytic leukemia with marked myelofibrosis.

  International journal of hematology 20011001

• Managing the glucocorticoid dependent inflammatory bowel disease patient.

  Seminars in gastrointestinal disease 20011001

• Medical management of ulcerative proctitis, proctosigmoiditis, and left-sided colitis.

  Seminars in gastrointestinal disease 20011001

• Modified cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone therapy for posttransplantation lymphoproliferative disease in pediatric patients undergoing solid organ transplantation.

  Journal of pediatric hematology/oncology 20011001

• Development of obesity and neurochemical backing in aurothioglucose-treated mice.

  Autonomic neuroscience : basic & clinical 20010917

• Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine.

  The Journal of biological chemistry 20010907

• Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010901

• Therapeutic drug monitoring of cytotoxic drugs.

  British journal of clinical pharmacology 20010901

• Neutropenia is not required for clinical remission during azathioprine therapy in inflammatory bowel disease.

  European journal of gastroenterology & hepatology 20010901

• Use of azathioprine or 6-mercaptopurine for treatment of steroid-dependent lymphocytic and collagenous colitis.

  The American journal of gastroenterology 20010901

• Therapy-related CD7+ acute myeloid leukemia with trisomy 8 following acute monocytic leukemia.

  Anti-cancer drugs 20010901

• Single-agent therapy with oral mercaptopurine for nonlymphoid blast crisis of chronic myeloid leukemia.

  Annals of hematology 20010901

• Long-term follow-up of the clinical efficacy of chemotherapy for acute myeloid leukemia at a single institute.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20010901

• Review article: the risk of lymphoma associated with inflammatory bowel disease and immunosuppressive treatment.

  Alimentary pharmacology & therapeutics 20010801

• Glucocorticoids and IL-10, but not 6-MP, 5-ASA or sulfasalazine block endothelial expression of MAdCAM-1: implications for inflammatory bowel disease therapy.

  Alimentary pharmacology & therapeutics 20010801

• [Metastatic Crohn's disease in childhood].

  Anales espanoles de pediatria 20010801

• Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.

  Cancer research 20010801

• An open-label pilot study using thioguanine as a therapeutic alternative in Crohn's disease patients resistant to 6-mercaptopurine therapy.

  Inflammatory bowel diseases 20010801

• 6-Thioguanine: a naked bullet? (Or how pharmacogenomics can make old drugs brand new).

  Inflammatory bowel diseases 20010801

• Reversal of cytosine arabinoside (ara-C) resistance by the synergistic combination of 6-thioguanine plus ara-C plus PEG-asparaginase (TGAP) in human leukemia lines lacking or expressing p53 protein.

  Cancer chemotherapy and pharmacology 20010801

• Photoactivation of DNA thiobases as a potential novel therapeutic option.

  Current biology : CB 20010724

• Antimycobacterial activity of 9-sulfonylated/sulfenylated-6-mercaptopurine derivatives.

  Bioorganic & medicinal chemistry letters 20010709

• Mechanism of activation of an immunosuppressive drug: azathioprine. Quantum chemical study on the reaction of azathioprine with cysteine.

  Journal of the American Chemical Society 20010704

• A comparison of early intensive methotrexate/mercaptopurine with early intensive alternating combination chemotherapy for high-risk B-precursor acute lymphoblastic leukemia: a Pediatric Oncology Group phase III randomized trial.

  Leukemia 20010701

• Outcome of acute lymphoblastic leukemia in children with AL90 regimen: impact of response to treatment and sex difference on prognostic factors.

  Medical and pediatric oncology 20010701

• If at first you don't succeed...Try again?

  The American journal of gastroenterology 20010701

• Azathioprine for atopic dermatitis.

  Clinical and experimental dermatology 20010701

• Treatment of acute promyelocytic leukaemia using a combination of all-trans retinoic acid and chemotherapy.

  Annals of the Academy of Medicine, Singapore 20010701

• Involvement of the NUP98 gene in a chromosomal translocation t(11;20)(p15;q11.2) in a patient with acute monocytic leukemia (FAB-M5b).

  International journal of hematology 20010701

• Repetitious appearance and disappearance of different kinds of clonal cytogenetic abnormalities after allogeneic bone marrow transplantation.

  International journal of hematology 20010701

• Pneumococcal arthritis affects performance status in patients with chronic GVHD of the skin following allogeneic bone marrow transplantation.

  International journal of hematology 20010701

• Prognostic impact of CD45 antigen expression in high-risk, childhood B-cell precursor acute lymphoblastic leukemia.

  Leukemia & lymphoma 20010701

• Results of a randomized phase III trial in children and adolescents with advanced stage diffuse large cell non Hodgkin's lymphoma: a Pediatric Oncology Group study.

  Leukemia & lymphoma 20010701

• Pediatric inflammatory bowel disease: clinical and therapeutic aspects.

  Current opinion in gastroenterology 20010701

• Improved methods for determining the concentration of 6-thioguanine nucleotides and 6-methylmercaptopurine nucleotides in blood.

  Journal of chromatography. B, Biomedical sciences and applications 20010605

• 6-Mercaptopurine for children newly diagnosed with Crohn's disease.

  Current gastroenterology reports 20010601

• Cost-utility of initial medical management for Crohn's disease perianal fistulae.

  Gastroenterology 20010601

• Magnetic resonance imaging detection of avascular necrosis of the bone in children receiving intensive prednisone therapy for acute lymphoblastic leukemia or non-Hodgkin lymphoma.

  Leukemia 20010601

• Rational dosing of azathioprine and 6-mercaptopurine.

  Gut 20010501

• Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease.

  Gut 20010501

• Treatment of refractory microscopic colitis with azathioprine and 6-mercaptopurine.

  Gastroenterology 20010501

• Conventional treatment of Crohn's disease: objectives and outcomes.

  Inflammatory bowel diseases 20010501

• Approach to corticosteroid-dependent and corticosteroid-refractory Crohn's disease.

  Inflammatory bowel diseases 20010501

• Crohn's disease of the esophagus: clinical features and outcomes.

  Inflammatory bowel diseases 20010501

• Treatment of childhood acute lymphoblastic leukemia. Long-term results of the AIEOP-ALL 87 study.

  Haematologica 20010501

• Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010415

• Hepatic dysfunction in children with acute lymphoblastic leukemia in remission: relation to hepatitis infection.

  Medical and pediatric oncology 20010401

• Genetic polymorphisms of thiopurine S-methyltransferase and 6-mercaptopurine toxicity in Japanese children with acute lymphoblastic leukaemia.

  Pharmacogenetics 20010401

• Allelotype frequency of the thiopurine methyltransferase (TPMT) gene in Japanese.

  Pharmacogenetics 20010401

• Thiopurine methyltransferase activity in the Jewish population of Israel.

  European journal of clinical pharmacology 20010401

• Genotype-phenotype correlation for thiopurine S-methyltransferase in healthy Italian subjects.

  European journal of clinical pharmacology 20010401

• Effect of the glutathione/glutathione disulfide redox couple on thiopurine methyltransferase.

  Biochemical pharmacology 20010315

• High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC.

  Clinical chemistry 20010301

• Fasting hypoglycemia is common during maintenance therapy for childhood acute lymphoblastic leukemia.

  The Journal of pediatrics 20010301

• Plasma pharmacokinetics and cerebrospinal fluid penetration of thioguanine in children with acute lymphoblastic leukemia: a collaborative Pediatric Oncology Branch, NCI, and Children's Cancer Group study.

  Cancer chemotherapy and pharmacology 20010301

• A novel protein complex distinct from mismatch repair binds thioguanylated DNA.

  Molecular pharmacology 20010201

• Testicular relapse in acute promyelocytic leukaemia.

  British journal of haematology 20010201

• Tautomerism and infrared spectra of 2-thiopurine: an experimental matrix isolation and theoretical ab initio and density functional theory study.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20010201

• Hepatic dysfunction as the presenting feature of acute lymphoblastic leukemia.

  Journal of pediatric hematology/oncology 20010201

• Smooth muscle tumor developing in an immunocompromised child after therapy for leukemia.

  Journal of pediatric hematology/oncology 20010201

• Tumor lysis syndrome in an infant with Langerhans cell histiocytosis successfully treated using continuous arteriovenous hemofiltration.

  Journal of pediatric hematology/oncology 20010201

• Intravenous cyclosporine in refractory pyoderma gangrenosum complicating inflammatory bowel disease.

  Inflammatory bowel diseases 20010201

• New developments in the immunosuppressive drug monitoring of cyclosporine, tacrolimus, and azathioprine.

  Clinical biochemistry 20010201

• Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone.

  Hematology/oncology clinics of North America 20010201

• A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn disease.

  Journal of pediatric gastroenterology and nutrition 20010201

• Langerhans' cell histiocytosis presenting with a para-aortic lesion and heart failure.

  Journal of the Formosan Medical Association = Taiwan yi zhi 20010201

• New bioactive sulfated metabolites from the Mediterranean tunicate Sidnyum turbinatum.

  Journal of natural products 20010201

• The use of denaturing high-pressure liquid chromatography for the detection of mutations in thiopurine methyltransferase.

  Journal of biochemical and biophysical methods 20010130

• Long-term results of TPMT activity monitoring in azathioprine-treated renal allograft recipients.

  Journal of the American Society of Nephrology : JASN 20010101

• Stochastic modeling in toxicokinetics. Application to the in vivo micronucleus assay.

  Mathematical biosciences 20010101

• De novo acute myeloid leukemia in the elderly; a consistent fraction of long-term survivors by standard-dose chemotherapy.

  Leukemia research 20010101

• Molecular dynamics of DNA quadruplex molecules containing inosine, 6-thioguanine and 6-thiopurine.

  Biophysical journal 20010101

• Frequency of use and standards of care for the use of azathioprine and 6-mercaptopurine in the treatment of inflammatory bowel disease: a systematic review of the literature and a survey of Canadian gastroenterologists.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20010101

• WAGR syndrome in a baby--the result of 6-MP treatment in a father affected by Crohn's disease?

  The American journal of gastroenterology 20010101

• Further evidence that 6-MP taken by the father with IBD provides risk of congenital anomaly to the pregnancy.

  The American journal of gastroenterology 20010101

• [Guidelines of the DGVS. Chronic active course. German Society of Digestive and Metabolic Diseases].

  Zeitschrift fur Gastroenterologie 20010101

• Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease.

  Scandinavian journal of gastroenterology 20010101

• 6-mercaptopurine dosage and pharmacokinetics influence the degree of bone marrow toxicity following high-dose methotrexate in children with acute lymphoblastic leukemia.

  Leukemia 20010101

• Severe life-threatening diarrhea caused by azathioprine but not by 6-mercaptopurine.

  Digestion 20010101

• Prognostic value of day 14 blast percentage and the absolute blast index in bone marrow of children with acute lymphoblastic leukemia.

  Pediatric hematology and oncology 20010101

• Intrathecal chemotherapy with antineoplastic agents in children.

  Paediatric drugs 20010101

• Cyclosporine in ulcerative colitis: state of the art.

  Acta gastro-enterologica Belgica 20010101

• [Treatment of acute lymphoblastic leukemia in adults as an unsolved problem].

  Terapevticheskii arkhiv 20010101

• [Experimental study of radiosensitizing effect of analogs of purines and pyrimidine bases in cultured HeLa cells].

  Vestnik Rossiiskoi akademii meditsinskikh nauk 20010101

• Pharmacokinetic considerations in the treatment of inflammatory bowel disease.

  Clinical pharmacokinetics 20010101

• Pharmacogenetics: the therapeutic drug monitoring of the future?

  Clinical pharmacokinetics 20010101

• Favorable outcome for children and adolescents with T-cell lymphoblastic lymphoma with an intensive ALL-type therapy without local radiotherapy.

  Annals of hematology 20010101

• Late effects of anticancer therapy on kidney function in children with acute lymphoblastic leukemia.

  Bratislavske lekarske listy 20010101

• Recent advances in the pharmacogenomics of thiopurine methyltransferase.

  The pharmacogenomics journal 20010101

• Dosing time-dependent pharmacological effects of anti-metabolites for rat cardiac graft.

  Research communications in molecular pathology and pharmacology 20010101

• Immune hemolytic anemia induced by 6-mercaptopurine.

  Transfusion 20000101

• Cognitive sequelae in children treated for acute lymphoblastic leukemia with dexamethasone or prednisone.

  Journal of pediatric hematology/oncology 20000101

• Veno-occlusive disease of the liver associated with thiopurines in a child with acute lymphoblastic leukemia.

  Pediatric hematology and oncology 20000101

• Assessment of brain perfusion by 99mTc-HMPAO SPECT in akinetic mutism due to high-dose intravenous methotrexate therapy.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 19971001

• Piperacillin-induced seizures.

  Clinical pediatrics 19970801

• Thiopurine methyltransferase activity in the erythrocytes of adults and children: and HPLC-linked assay.

  Clinica chimica acta; international journal of clinical chemistry 19970318

• 6-Mercaptopurine decreases the Bcl-2/Bax ratio and induces apoptosis in activated splenic B lymphocytes.

  Molecular pharmacology 19970301

• Myelodysplastic syndrome following successful therapy of acute promyelocytic leukemia.

  Leukemia 19970101

• The successful treatment of autoimmune hepatitis with 6-mercaptopurine after failure with azathioprine.

  Gastroenterology 19960101

• Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide.

  European journal of clinical pharmacology 19960101

• HPLC analysis of azathioprine metabolites in red blood cells, plasma and urine in renal transplant recipients.

  International journal of clinical pharmacology and therapeutics 19951201

• Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii.

  Biochemical pharmacology 19951109

• Low-dose 6-mercaptopurine in inflammatory bowel disease is associated with minimal hematologic toxicity.

  Digestive diseases and sciences 19940801

• Behavioral effects of corticosteroids in children with acute lymphoblastic leukemia.

  Medical and pediatric oncology 19920101

• Hepatocellular carcinoma and bladder cancer as complications following five years of chemotherapy for acute myeloblastic leukemia.

  Japanese journal of medicine 19900101

• An adult case of acute lymphoblastic leukemia with necrotizing leukoencephalopathy.

  Japanese journal of medicine 19900101

• Protection against isoproterenol-induced myocardial necrosis in rats by 6-mercaptopurine and 6-thioguanine or by irradiation.

  Research communications in chemical pathology and pharmacology 19890301

• Aggressive treatment improves survival in adult acute lymphoblastic leukemia.

  European journal of haematology 19881101

• [Acute pericarditis caused by daunorubicin in acute myelocytic leukemia].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 19880601

• Severe vincristine neurotoxicity in a patient with Charcot-Marie-Tooth disease.

  Pediatric hematology and oncology 19880101

• Hepatocellular carcinoma in a long-term survivor of acute lymphocytic leukemia.

  Cancer 19871115

• [Daunomycin-induced cardiogenic shock in a case of acute myelogenous leukemia].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 19870901

• Superior sagittal sinus thrombosis associated with Evans' syndrome of haemolytic anaemia.

  Journal of neurology 19850101

• [Porphyria cutanea tarda caused by methotrexate and buthiopurine therapy].

  Zeitschrift fur Hautkrankheiten 19830215

• Antiviral effects if ribavirin and 6-mercapto-9-tetrahydro-2-furylpurine against dengue viruses in vitro.

  Antiviral research 19820501

• Muscular degeneration in rats after postnatal treatment with 6-mercaptopurine.

  Drug and chemical toxicology 19810101

• Hypersensitivity and jaundice due to azathioprine.

  Postgraduate medical journal 19800401

• [Hemolysis after combined azathioprine and allopurinol therapy].

  Acta medica Austriaca 19790101

• Encephalomyelopathy following intrathecal methotrexate treatment in a child with acute leukemia.

  Cancer 19780901

• Neuraxonal dystrophy of the brain in patients receiving antineoplastic chemotherapy.

  Acta neuropathologica 19770331

• Cytogenetic studies in a patient with acute granulocytic leukemia of seven and one-half years duration.

  Blood 19751101

• [Carcinoma of the liver in a child after seven-year complete remission of acute lymphoblastic leukaemia(author's transl)].

  Deutsche medizinische Wochenschrift (1946) 19750905

• Immunosuppressive and cytotoxic chemotherapy: long-term complications.

  Annals of internal medicine 19750101

• Combination therapy in 130 patients with acute lymphoblastic leukemia (protocol 06 LA 66-Paris).

  Cancer research 19731201

• Seizures associated with vincristine sulfate therapy.

  The Journal of pediatrics 19730401

• Anemias with renal transplantation.

  JAMA 19720911

• Hematuria and crystalluria after high-dose 6-mercaptopurine administration.

  The New England journal of medicine 19720810

• Daunorubicin. Results in childhood leukaemia.

  Archives of disease in childhood 19720401

• 6-Azauridine in combination chemotherapy of childhood acute myelocytic leukemia.

  Cancer 19720401

• Clinical note: allergic reaction to daunomycin (NSC-82151).

  Cancer chemotherapy reports 19701201

• Development of myeloblastoma with massive breast and ovarian involvement during remission in acute leukemia.

  Cancer 19691001

• Purine analogs as potential anticytomegalovirus agents.

  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19690901

• Vincristine-induced neuropathy. A clinical study of fifty leukemic patients.

  Neurology 19690401

• Neurofibrillary degeneration induced by vincristine therapy.

  Archives of neurology 19690201

• Neuropathy in lymphoblastic leukemia treated with vincristine.

  Archives of neurology 19670401