50-91-9 | 5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$6.00	$4.00
250mg	98%	in stock	$9.00	$6.00
1g	98%	in stock	$15.00	$11.00
5g	95%	in stock	$43.00	$31.00
10g	95%	in stock	$78.00	$55.00
25g	98%	in stock	$194.00	$136.00

Description

• Catalog Number: AB47386
• Chemical Name: 5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
• CAS Number: 50-91-9
• Molecular Formula: C9H11FN2O5
• Molecular Weight: 246.1924
• MDL Number: MFCD00006530
• SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

Computed Properties

• Complexity: 386
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 3
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 2
• XLogP3: -1.2

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  Cancer science 20100301

• Azidothymidine enhances fluorodeoxyuridine-mediated radiosensitization.

  International journal of radiation oncology, biology, physics 20100301

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• Alternating systemic and hepatic artery infusion therapy for resected liver metastases from colorectal cancer: a North Central Cancer Treatment Group (NCCTG)/ National Surgical Adjuvant Breast and Bowel Project (NSABP) phase II intergroup trial, N9945/CI-66.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100210

• Comparison of average, scaled average, and population bioequivalence methods for assessment of highly variable drugs: an experience with doxifluridine in beagle dogs.

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• Liposome formulations of hydrophobic drugs.

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• Therapeutic usefulness of postoperative adjuvant chemotherapy with Tegafur-Uracil (UFT) in patients with breast cancer: focus on the results of clinical studies in Japan.

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• Prospective evaluation of microscopic extension using whole-mount preparation in patients with hepatocellular carcinoma: Definition of clinical target volume for radiotherapy.

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  Clinical cancer research : an official journal of the American Association for Cancer Research 20090115

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  Clinical pharmacokinetics 20090101

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  Japanese journal of clinical oncology 20080301

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  Journal of mass spectrometry : JMS 20080201

• Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides.

  Bioorganic & medicinal chemistry 20080201

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• Docetaxel, low-dose estramustine, and doxifluridine in hormone-refractory metastatic prostate cancer.

  Cancer chemotherapy and pharmacology 20080101

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• Enhancing the activity and regioselectivity of lipases for 3'-benzoylation of floxuridine and its analogs by using ionic liquid-containing systems.

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• Fixed dose rate infusion of gemcitabine with oral doxifluridine and leucovorin for advanced unresectable pancreatic cancer: a phase II study.

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  Indian journal of ophthalmology 20080101

• Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans.

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• Hemorrhage associated with hepatic artery pseudoaneurysms after regional chemotherapy with floxuridine: case report.

  International seminars in surgical oncology : ISSO 20080101

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  Nucleic acids symposium series (2004) 20080101

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• Long-term actions of interleukin-1beta on delay and tonic firing neurons in rat superficial dorsal horn and their relevance to central sensitization.

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• Hand-foot syndrome due to capecitabine.

  Indian journal of dermatology 20080101

• Institutional guidelines and ongoing studies in management of liver tumours: the experience of the European Institute of Oncology.

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  Annals of oncology : official journal of the European Society for Medical Oncology 20071201

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  Anti-cancer drugs 20070901

• Bioavailability of the amino acid-attached prodrug as a new anti-HIV agent in rats.

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• Development and characterization of a model of liver metastasis using human colon cancer HCT-116 cells.

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  Ai zheng = Aizheng = Chinese journal of cancer 20070801

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  Japanese journal of clinical oncology 20070801

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• [An inadvertent contraindicated combined use of newly prescribed TS-1 and unused doxifluridine].

  Gan to kagaku ryoho. Cancer & chemotherapy 20070401

• Doxifluridine combined with weekly paclitaxel for second-line treatment in patients with gastric cancer resistant to TS-1.

  International journal of clinical oncology 20070401

• Coencapsulation of irinotecan and floxuridine into low cholesterol-containing liposomes that coordinate drug release in vivo.

  Biochimica et biophysica acta 20070301

• Organotypic slice culture of the hypothalamic paraventricular nucleus of rat.

  Journal of veterinary science 20070301

• [Combination therapy with bi-weekly docetaxel and 5'-deoxy-5-fluorouridine for advanced gastric cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20070301

• A possible role of thymidine phosphorylase expression and 5-fluorouracil increased sensitivity in oropharyngeal cancer patients.

  Journal of cellular and molecular medicine 20070301

• Developmental switch in the effects of TNFalpha on ventral midbrain dopaminergic neurons.

  Neuroscience research 20070201

• [A case of recurrent gastric cancer with peritoneal dissemination responding to doxifluridine/paclitaxel combination chemotherapy as third-line treatment].

  Gan to kagaku ryoho. Cancer & chemotherapy 20070201

• The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells.

  British journal of cancer 20070115

• Rapid and simultaneous determination of capecitabine and its metabolites in mouse plasma, mouse serum, and in rabbit bile by high-performance liquid chromatography.

  Journal of chromatography. A 20070105

• Caspase-dependent and -independent induction of phosphatidylserine externalization during apoptosis in human renal carcinoma Cak(1)-1 and A-498 cells.

  Toxicology 20070105

• Tezacitabine enhances the DNA-directed effects of fluoropyrimidines in human colon cancer cells and tumor xenografts.

  Biochemical pharmacology 20070101

• Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines.

  The international journal of biochemistry & cell biology 20070101

• In vitro and in vivo antileukemic effect of novel dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine.

  Neoplasma 20070101

• Interventionally implanted port catheter systems for hepatic arterial infusion of chemotherapy in patients with colorectal liver metastases: a Phase II-study and historical comparison with the surgical approach.

  BMC cancer 20070101

• Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20070101

• A clinical study of docetaxel with or without 5'DFUR as a second-line chemotherapy for advanced gastric cancer.

  Medical oncology (Northwood, London, England) 20070101

• Significance of thymidine phosphorylase in metronomic chemotherapy using CPT-11 and doxifluridine for advanced colorectal carcinoma.

  Anticancer research 20070101

• Chemosensitivity-related genes of breast cancer detected by DNA microarray.

  Anticancer research 20070101

• Increased preclinical efficacy of irinotecan and floxuridine coencapsulated inside liposomes is associated with tumor delivery of synergistic drug ratios.

  Oncology research 20070101

• Proteome and transcriptome analysis of cell death induced by 5-fluoro-2'-deoxyuridine.

  Nucleic acids symposium series (2004) 20070101

• Oral fluoropyrimidines may not reduce the risk of postoperative recurrence in colorectal cancer associated with mesenteric lymph node metastasis.

  International surgery 20070101

• A comparative study of intratumoral chemotherapy in advanced childhood common solid tumors.

  Indian journal of urology : IJU : journal of the Urological Society of India 20070101

• Capecitabine: an evidence-based review of its effectiveness in the treatment of carcinoma of the pancreas.

  Core evidence 20070101

• Human equilibrative nucleoside transporter-1 (hENT1) is required for the transcriptomic response of the nucleoside-derived drug 5'-DFUR in breast cancer MCF7 cells.

  Biochemical pharmacology 20061215

• Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicity.

  Cancer letters 20061208

• Intestinal tract injury by drugs: Importance of metabolite delivery by yellow bile road.

  Pharmacology & therapeutics 20061201

• Rapid microwave-assisted fluorination yielding novel 5'-deoxy-5'-fluorouridine derivatives.

  Bioorganic & medicinal chemistry letters 20061201

• 5-FdUrd-araC heterodinucleoside re-establishes sensitivity in 5-FdUrd- and AraC-resistant MCF-7 breast cancer cells overexpressing ErbB2.

  Differentiation; research in biological diversity 20061201

• Unresectable gastric cancer with multiple liver metastases effectively treated with combined paclitaxel and doxifluridine chemotherapy.

  International journal of clinical oncology 20061201

• Is thymidylate synthase a reliable predictor for response and survival during hepatic arterial infusion for hepatic metastases from colorectal cancer?

  British journal of cancer 20061106

• Irinotecan cytotoxicity does not necessarily depend on the UGT1A1 polymorphism but on fluoropyrimidine: a molecular case report.

  Oncology reports 20061101

• p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.

  PLoS genetics 20061101

• [A treatment for pulmonary metastases from colorectal cancer by pre-operative CPT-11/5'-DFUR combination therapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20061101

• [A case of colon cancer liver metastases treated by combined therapies].

  Gan to kagaku ryoho. Cancer & chemotherapy 20061101

• Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: a model for patient classification to aid fluoropyrimidine therapy.

  Cancer research 20061001

• Nonsurgical approaches to colorectal cancer.

  The oncologist 20061001

• [Effectiveness of preoperative chemoradiotherapy for advanced rectal cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20061001

• [A case of advanced gastric cancer--efficacy of combination therapy of doxifluridine and weekly paclitaxel].

  Gan to kagaku ryoho. Cancer & chemotherapy 20061001

• [A case of stage IVA intrahepatic biliary tract cancer successfully treated with gemcitabine].

  Gan to kagaku ryoho. Cancer & chemotherapy 20061001

• Pump removal in infected patients with hepatic chemotherapy pumps: when is it necessary?

  The American surgeon 20061001

• Uridine phosphorylase in breast cancer: a new prognostic factor?

  Frontiers in bioscience : a journal and virtual library 20060901

• A phase II trial of neoadjuvant cisplatin-fluorouracil followed by postoperative intraperitoneal floxuridine-leucovorin in patients with locally advanced gastric cancer.

  Annals of oncology : official journal of the European Society for Medical Oncology 20060901

• The relationship of premature mitosis to cytotoxicity in response to checkpoint abrogation and antimetabolite treatment.

  Cell cycle (Georgetown, Tex.) 20060901

• Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase.

  Cancer research 20060901

• [A case of local recurrence of rectal cancer in long-term responding to combined therapy of low-dose CPT-11 and 5'-DFUR].

  Gan to kagaku ryoho. Cancer & chemotherapy 20060901

• Thymidylate synthase as a chemotherapeutic drug target: where are we after fifty years?

  Cancer biology & therapy 20060901

• The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitro.

  Cancer chemotherapy and pharmacology 20060801

• A proposed clinical test for monitoring fluoropyrimidine therapy: detection and stability of thymidylate synthase ternary complexes.

  Cancer biology & therapy 20060801

• Synergistic cytotoxic interaction in hormone-refractory prostate cancer with the triple combination docetaxel-erlotinib and 5-fluoro-5'-deoxyuridine.

  Anti-cancer drugs 20060801

• Relationship between AUC of 5'-DFUR and toxicity of capecitabine, fluoropyrimidine carbamate analogs, and 5'-DFUR in monkeys, mice, and rats.

  The Journal of toxicological sciences 20060801

• The role of haemoglobin level in predicting the response to first-line chemotherapy in advanced colorectal cancer patients.

  British journal of cancer 20060703

• Molecular imaging with 123I-FIAU, 18F-FUdR, 18F-FET, and 18F-FDG for monitoring herpes simplex virus type 1 thymidine kinase and ganciclovir prodrug activation gene therapy of cancer.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20060701

• Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling.

  PLoS genetics 20060701

• Ratiometric dosing of anticancer drug combinations: controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice.

  Molecular cancer therapeutics 20060701

• Concurrent chemoradiotherapy with doxifluridine and paclitaxel for extrahepatic bile duct cancer.

  American journal of clinical oncology 20060601

• [Evaluation of safety and efficacy for bi-weekly Docetaxel and 5'-DFUR combination therapy in patients with advanced or recurrent breast cancer--Phase I study].

  Gan to kagaku ryoho. Cancer & chemotherapy 20060601

• Endoscopic ultrasound restaging after neoadjuvant chemotherapy in esophageal cancer.

  The American journal of gastroenterology 20060601

• The MMP-9 expression determined the efficacy of postoperative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer.

  Cancer chemotherapy and pharmacology 20060501

• Short fluorodeoxyuridine exposure of different human glioblastoma lines induces high-level accumulation of S-phase cells that avidly incorporate 125I-iododeoxyuridine.

  European journal of nuclear medicine and molecular imaging 20060501

• Downstaging colorectal liver metastases by concomitant unilateral portal vein ligation and selective intra-arterial chemotherapy.

  The British journal of surgery 20060501

• High-performance liquid chromatographic method for the determination of gemcitabine and 2',2'-difluorodeoxyuridine in plasma and tissue culture media.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060501

• The expression of vascular endothelial growth factor determines the efficacy of post-operative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer.

  Oncology reports 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Improved survival and response to hepatic infusion.

  The Lancet. Oncology 20060501

• Adjuvant hepatic chemotherapy after resection of solitary hepatocellular carcinoma associated with hepatitis B virus cirrhosis.

  Hepatobiliary & pancreatic diseases international : HBPD INT 20060501

• Emerging efficacy endpoints for targeted therapies in advanced renal cell carcinoma.

  Oncology (Williston Park, N.Y.) 20060501

• Modulation of uridine phosphorylase gene expression by tumor necrosis factor-alpha enhances the antiproliferative activity of the capecitabine intermediate 5'-deoxy-5-fluorouridine in breast cancer cells.

  Molecular pharmacology 20060401

• Pharmacokinetics of gemcitabine and its primary metabolite in dogs after intravenous bolus dosing and its in vitro pharmacodynamics.

  Journal of veterinary pharmacology and therapeutics 20060401

• Pharmacokinetics of gemcitabine and its primary metabolite in dogs after intravenous infusion.

  Journal of veterinary pharmacology and therapeutics 20060401

• [A case of gastric cancer with multiple liver metastases resistant to TS-1 responding to chemotherapy with paclitaxel plus doxifluridine].

  Gan to kagaku ryoho. Cancer & chemotherapy 20060401

• Chemotherapy-induced sclerosing cholangitis: long-term response to endoscopic therapy.

  Journal of clinical gastroenterology 20060401

• Supportive care in the management of colon cancer.

  Supportive cancer therapy 20060401

• Apoptosis induced by preoperative oral 5'-DFUR administration in gastric adenocarcinoma and its mechanism of action.

  World journal of gastroenterology 20060307

• [Combined chemotherapy with weekly Paclitaxel and doxifluridine for advanced and recurrent gastric cancers].

  Gan to kagaku ryoho. Cancer & chemotherapy 20060301

• [A case of recurrent gastric cancer effectively treated by combination chemotherapy of weekly paclitaxel and 5'- DFUR after showing resistance to weekly paclitaxel].

  Gan to kagaku ryoho. Cancer & chemotherapy 20060301

• Analysis of mechanisms contributing to AraC-mediated chemoresistance and re-establishment of drug sensitivity by the novel heterodinucleoside phosphate 5-FdUrd-araC.

  Apoptosis : an international journal on programmed cell death 20060301

• 3D-QSAR studies on antitubercular thymidine monophosphate kinase inhibitors based on different alignment methods.

  Bioorganic & medicinal chemistry letters 20060215

• Nucleoside ester prodrug substrate specificity of liver carboxylesterase.

  The Journal of pharmacology and experimental therapeutics 20060201

• Interaction of intestinal nucleoside transporter hCNT2 with amino acid ester prodrugs of floxuridine and 2-bromo-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole.

  Biological & pharmaceutical bulletin 20060201

• [A long-term survivor with stage IV gastric cancer due to postoperative weekly paclitaxel and 5'-DFUR combination therapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20060201

• [Efficacy of FAEV regimen in treatment of high-risk drug-resistant gestational trophoblastic tumor].

  Zhonghua fu chan ke za zhi 20060201

• Nuclear expression of thymidylate synthase in colorectal cancer cell lines and clinical samples.

  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20060101

• Upregulation of thymidine phosphorylase in rectal cancer tissues by mitomycin C.

  Journal of surgical oncology 20060101

• Radiation sensitiser effective against liver disease.

  The Lancet. Oncology 20060101

• Altered mouse leukemia L1210 thymidylate synthase, associated with cell resistance to 5-fluoro-dUrd, is not mutated but rather reflects posttranslational modification.

  Acta biochimica Polonica 20060101

• Hepatic arterial infusion of chemotherapy for hepatic metastases from colorectal cancer.

  Cancer control : journal of the Moffitt Cancer Center 20060101

• Comparative effects of the administration period of adjuvant chemotherapy using doxifluridine (5'-DFUR) for 1 year versus 3 years after breast cancer surgery by the Shimane Breast Cancer Study Group.

  Anticancer research 20060101

• The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells.

  The international journal of biochemistry & cell biology 20060101

• Dopamine presynaptically and heterogeneously modulates nucleus accumbens medium-spiny neuron GABA synapses in vitro.

  BMC neuroscience 20060101

• Transient expression of Drosophila melanogaster deoxynucleoside kinase gene enhances cytotoxicity of nucleoside analogs.

  Nucleosides, nucleotides & nucleic acids 20060101

• Synthesis and biological activity of N-2,3-dihydroxypropyl-N-4-chlorobutyl nucleoside phosphoramidate prodrugs.

  Molecular pharmaceutics 20060101

• Clinical usefulness of oral combination chemotherapy of 5'-deoxy-5-fluorouridine (5'-DFUR) and cyclophosphamide for metastatic breast cancer.

  Breast cancer (Tokyo, Japan) 20060101

• Proteome and transcriptome analysis of 5-fluoro-2'-deoxyuridine-induced cell death mechanisms.

  Nucleic acids symposium series (2004) 20060101

• Morphine stimulates CCL2 production by human neurons.

  Journal of neuroinflammation 20060101

• Hepatic arterial chemotherapy in combination with systemic chemotherapy compared with hepatic arterial chemotherapy alone for liver metastases from colorectal cancer: results of a multi-centric randomized study.

  In vivo (Athens, Greece) 20060101

• Hepatic metastases of colorectal cancer: locoregional intra-arterial treatment.

  Anticancer research 20060101

• Trans-arterial hepatic radioembolisation of yttrium-90 microspheres.

  Biomedical imaging and intervention journal 20060101

• Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides.

  Bioorganic & medicinal chemistry 20051215

• Effects on DNA and RNA after the administration of two different schedules of 5-fluorouracil in colorectal cancer patients.

  Cancer chemotherapy and pharmacology 20051201

• Pharmacokinetic modelling of 5-FU production from capecitabine--a population study in 40 adult patients with metastatic cancer.

  Journal of pharmacokinetics and pharmacodynamics 20051201

• Phase II trial of high-dose conformal radiation therapy with concurrent hepatic artery floxuridine for unresectable intrahepatic malignancies.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051201

• [Pharmacokinetic comparison of capecitabine and 5'-deoxy-5-fluorouridine (doxifluridine; 5'-DFUR)].

  Gan to kagaku ryoho. Cancer & chemotherapy 20051201

• Lifespan extending activity of substances secreted by the nematode Caenorhabditis elegans that include the dauer-inducing pheromone.

  Bioscience, biotechnology, and biochemistry 20051201

• Neoadjuvant chemotherapy, surgery, and adjuvant intraperitoneal chemotherapy in patients with locally advanced gastric or gastroesophageal junction carcinoma: a phase II study.

  Seminars in oncology 20051201

• Simultaneous determination of capecitabine and its metabolites by HPLC and mass spectrometry for preclinical and clinical studies.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051105

• Polymorphic tandem repeat sequences of the thymidylate synthase gene correlates with cellular-based sensitivity to fluoropyrimidine antitumor agents.

  Cancer chemotherapy and pharmacology 20051101

• [A case of advanced gastric cancer with direct invasion of the transverse colon responding to paclitaxel/5'-DFUR combined therapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20051101

• Phase I clinical and pharmacologic study of a 2-weekly administration of cisplatin and gemcitabine in patients with advanced non-small cell lung cancer.

  Anti-cancer drugs 20051001

• [Prediction and treatment of peritoneal dissemination in gastric cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20051001

• [Case report--postoperative continuous intraarterial infusion of small doses of 5-FU successfully controlled residual tumor and liver metastasis of stage IV gastric cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20051001

• [A case of metastatic colon cancer treated with oxaliplatin combination chemotherapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20051001

• [A case of chemoradiation with tissue expander for local reccurence of rectal cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20051001

• Preferential inhibition of bone metastases by 5'-deoxy-5-fluorouridine and capecitabine in the 4T1/luc mouse breast cancer model.

  Oncology reports 20050901

• Floxuridine amino acid ester prodrugs: enhancing Caco-2 permeability and resistance to glycosidic bond metabolism.

  Pharmaceutical research 20050901

• [Experience of weekly paclitaxel combined with orally administered doxifluridine therapy for advanced and recurrent gastric cancer-preliminary study].

  Gan to kagaku ryoho. Cancer & chemotherapy 20050901

• Level of 5-fluorodeoxyuridine 5'-monophosphate in cancerous tissue in patients with gastric cancer under preoperative administration of TS-1. A preliminary study.

  Journal of experimental & clinical cancer research : CR 20050901

• A phase I study of doxifluridine combined with weekly paclitaxel for metastatic gastric cancer.

  Cancer chemotherapy and pharmacology 20050801

• Pharmacokinetic and pharmacodynamic comparison of fluoropyrimidine derivatives, capecitabine and 5'-deoxy-5-fluorouridine (5'-DFUR).

  Cancer chemotherapy and pharmacology 20050801

• Transfection of thymidine phosphorylase cDNA to human hepatocellular carcinoma cells enhances sensitivity to fluoropyrimidine but augments endothelial cell migration.

  Journal of cancer research and clinical oncology 20050801

• Phase I trial of systemic oxaliplatin combination chemotherapy with hepatic arterial infusion in patients with unresectable liver metastases from colorectal cancer.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050801

• A role for hepatic-directed chemotherapy in colorectal liver metastases.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050801

• Improved hepatic toxicity profile of portal vein adjuvant hepatic infusional chemotherapy.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050801

• Hepatic arterial infusion of floxuridine and dexamethasone plus high-dose Mitomycin C for patients with unresectable hepatic metastases from colorectal carcinoma.

  Journal of surgical oncology 20050801

• Continuous intrathecal administration of 5-fluoro-2'-deoxyuridine for the treatment of neoplastic meningitis.

  Neurosurgery 20050801

• [Experience with capecitabine in patients with anthracycline and/or taxane-resistant recurrent breast cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20050801

• Intrathecal administration of Y-27632, a specific rho-associated kinase inhibitor, for rat neoplastic meningitis.

  Molecular cancer research : MCR 20050801

• Improvement in 5-fluorouracil (5-FU) and 5-fluoro-2'-deoxyuridine (FdUrd) concentration by 5-fluorouracil-polyethylene-glycol-liposomes in abdominal stop-flow: treatment of VX2 liver-tumor-bearing rabbits.

  Journal of chemotherapy (Florence, Italy) 20050801

• 5-Fluorouracil concentration in blood, liver and tumor tissues and apoptosis of tumor cells after preoperative oral 5'-deoxy-5-fluorouridine in patients with hepatocellular carcinoma.

  World journal of gastroenterology 20050707

• Cytotoxic effects of novel amphiphilic dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine in cross-resistant H9 human lymphoma cells.

  Leukemia research 20050701

• Correlations between antitumor activities of fluoropyrimidines and DPD activity in lung tumor xenografts.

  Oncology reports 20050701

• Enhancement of antitumor activity of 5'-deoxy-5-fluorouridine (Furtulon) by taxane in human gastric cancer xenografts.

  Oncology reports 20050701

• Combination of 5-deoxy-5-fluorouridine and tamoxifen show cell-type specific antagonistic and cooperative effects on cytotoxicity in human mammary carcinoma cells.

  Oncology reports 20050701

• A human osteosarcoma cell line expressing herpes simplex type-1 thymidine kinase: studies with radiolabeled (E)-5-(2-iodovinyl)-2'-fluoro-2'-deoxyuridine.

  Nuclear medicine and biology 20050701

• Enhancement of 5-fluorouracil sensitivity by an rTS signaling mimic in H630 colon cancer cells.

  Cancer research 20050701

• [Long-term survival in a case of large bowel cancer--efficacy of CPT-11-based chemotherapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20050701

• Charge transfer excited-state dynamics in DNA duplexes substituted with an ethynylpyrenyldeoxyuridine electron source and a fluorodeoxyuridine electron trap.

  The journal of physical chemistry. B 20050623

• Effects of oral 5-fluorouracil drugs on hepatic fat content in patients with colon cancer.

  Academic radiology 20050601

• Bile duct complications of hepatic arterial infusion chemotherapy evaluated by helical CT.

  Clinical radiology 20050601

• Hypoxia-selective activation of 5-fluorodeoxyuridine prodrug possessing indolequinone structure: radiolytic reduction and cytotoxicity characteristics.

  Bioorganic & medicinal chemistry letters 20050502

• Doxycycline may reduce the incidence of aneurysms in haemodialysis vascular accesses.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20050501

• The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.

  Molecular cancer therapeutics 20050501

• [Bi-weekly chemotherapy with medium-dose docetaxel for advanced and recurrent breast cancers (The 15th study of Keiji Breast Cancer Study Group)].

  Gan to kagaku ryoho. Cancer & chemotherapy 20050501

• [Two cases of advanced breast cancer responding to oral chemoendocrine therapy with 5'-deoxy-5-fluorouridine, medroxyprogesterone acetate and cyclophosphamide (DMpC)].

  Gan to kagaku ryoho. Cancer & chemotherapy 20050501

• Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes.

  The Journal of biological chemistry 20050422

• Yeast DEL assay detects clastogens.

  Mutation research 20050404

• Development of a stereological method to measure levels of fluoropyrimidine metabolizing enzymes in tumor sections using laser scanning cytometry.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20050401

• Thymidine phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal cancer patients.

  Oncology reports 20050401

• Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050401

• Targeted delivery to PEPT1-overexpressing cells: acidic, basic, and secondary floxuridine amino acid ester prodrugs.

  Molecular cancer therapeutics 20050401

• [A case of recurrent breast cancer with multiple lung, adrenal, inferior vena cava tumor thrombus and bone metastases successfully treated with 5'-DFUR and hormonal therapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20050401

• Is there a new drug beyond floxuridine for intra-arterial hepatic chemotherapy in liver metastases from colorectal cancer?

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050320

• Tumor necrosis factor alpha-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cells mediated through IKK.

  The Journal of biological chemistry 20050304

• Taxotere-5'-deoxy-5-fluorouridine combination on hormone-refractory human prostate cancer cells.

  Anti-cancer drugs 20050301

• Sequential treatment with irinotecan and doxifluridine: optimal dosing schedule in murine models and in a phase I study for metastatic colorectal cancer.

  Chemotherapy 20050301

• [Weekly paclitaxel administration and intraabdominal CBDCA injection possibly beneficial treatment for recurrent breast cancer associated with metastatic ovarian cancer and peritoneal dissemination after operation--a case report].

  Gan to kagaku ryoho. Cancer & chemotherapy 20050301

• [Effective reduction of elevated tumor markers by exemestane--a 12-year follow-up of a case of bone metastatic breast cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20050301

• A new class of 5-fluoro-2'-deoxyuridine prodrugs conjugated with a tumor-homing cyclic peptide CNGRC by ester linkers: synthesis, reactivity, and tumor-cell-selective cytotoxicity.

  Pharmaceutical research 20050301

• DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.

  The Journal of biological chemistry 20050218

• Global expression changes resulting from loss of telomeric DNA in fission yeast.

  Genome biology 20050101

• Gene expression profiling revealed novel mechanism of action of Taxotere and Furtulon in prostate cancer cells.

  BMC cancer 20050101

• Advanced gastric cancer with peritoneal dissemination successfully treated with paclitaxel and doxifluridine: a case report.

  Hepato-gastroenterology 20050101

• Heterodinucleoside phosphates of 5-fluorodeoxyuridine and arabinofuranosylcytosine--new drugs in cancer chemotherapy?

  In vivo (Athens, Greece) 20050101

• A combination phase I study of weekly paclitaxel and doxifluridine in advanced gastric cancer patients.

  Anticancer research 20050101

• CD134 as target for specific drug delivery to auto-aggressive CD4+ T cells in adjuvant arthritis.

  Arthritis research & therapy 20050101

• Localized hand-foot syndrome after intra-arterial hepatic chemotherapy with floxuridine: a clinical case.

  Tumori 20050101

• Cancer cell adaptation to chemotherapy.

  BMC cancer 20050101

• An encoded N-terminal extension results in low levels of heterologous protein production in Escherichia coli.

  Microbial cell factories 20050101

• Intravesical gemcitabine in superficial bladder cancer: a phase II safety, efficacy and pharmacokinetic study.

  Anticancer research 20050101

• The benefit of post-operative adjuvant chemotherapy using oral fluoropyrimidines in rectal cancer.

  The Kurume medical journal 20050101

• Recognition of an unnatural difluorophenyl nucleotide by uracil DNA glycosylase.

  Biochemistry 20041214

• Gene expression profiles of colorectal carcinoma in response to neo-adjuvant chemotherapy.

  International journal of oncology 20041201

• Determination of gemcitabine and its metabolite in human plasma using high-pressure liquid chromatography coupled with a diode array detector.

  Acta pharmacologica Sinica 20041201

• A prospective randomized study of gemcitabine with doxifluridine versus paclitaxel with doxifluridine in concurrent chemoradiotherapy for locally advanced pancreatic cancer.

  International journal of radiation oncology, biology, physics 20041201

• Morbidity of adjuvant hepatic arterial infusion pump chemotherapy in the management of colorectal cancer metastatic to the liver.

  American journal of surgery 20041201

• [Successful combination therapy with 5'-DFUR and MPA for breast cancer with spinal and vertebral metastases].

  Gan to kagaku ryoho. Cancer & chemotherapy 20041201

• [Docetaxel (TXT), epirubicin (EPI) and doxifluridine (5'-DFUR) combination neoadjuvant chemotherapy for outpatients with locally advanced breast cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20041201

• [Significance of tissue thymidine phosphorylase and dihydropyrimidine dehydrogenase activities in ovarian cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20041201

• Phase I clinical trial of fixed-dose rate infusional gemcitabine and dacarbazine in the treatment of advanced soft tissue sarcoma, with assessment of gemcitabine triphosphate accumulation.

  Cancer 20041115

• Important role of the dihydrouracil/uracil ratio in marked interpatient variations of fluoropyrimidine pharmacokinetics and pharmacodynamics.

  Journal of clinical pharmacology 20041101

• Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.

  Anti-cancer drugs 20041101

• Integrated FDG PET/CT in patients with persistent ovarian cancer: correlation with histologic findings.

  Radiology 20041101

• [Current combination chemotherapy containing paclitaxel for advanced, recurrent gastric cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20041101

• A phase II trial of FUdR in patients with advanced pancreatic cancer.

  Journal of cancer research and clinical oncology 20041001

• Distribution of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20041001

• [Combination therapy with Anastrozole and 5'-DFUR as a treatment for metastatic breast cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20041001

• The efficacy of long-term oral chemotherapy with 5'-deoxy-5-fluorouridine and cyclophosphamide for recurrent breast cancer.

  International journal of clinical oncology 20041001

• [A case of disseminated tumor from cecal cancer with survival for over 5 years after twice surgical resection and systemic chemotherapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20041001

• [A case of long-term survival after chemo-radiation for postoperative local recurrence of rectal cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20041001

• [Effectiveness of chemoradiotherapy for three cases of squamous cell anal carcinoma].

  Gan to kagaku ryoho. Cancer & chemotherapy 20041001

• A non-radioactive sensitive assay to measure 5-fluorouracil incorporation into DNA of solid tumors.

  Nucleosides, nucleotides & nucleic acids 20041001

• 5-Fluoro-2'-deoxyuridine has effects on mitochondria in CEM T-lymphoblast cells.

  Nucleosides, nucleotides & nucleic acids 20041001

• Effect of fluoropyrimidines on the growth of Ureaplasma urealyticum.

  Nucleosides, nucleotides & nucleic acids 20041001

• Cytotoxic and apoptotic effects of novel heterodinucleoside phosphates consisting of 5-fluorodeoxyuridine and Ara-C in human cancer cell lines.

  Nucleosides, nucleotides & nucleic acids 20041001

• Investigation of the pharmacokinetics of gemcitabine and 2',2'-difluorodeoxyuridine in human plasma by liquid chromatography.

  Analytical biochemistry 20040915

• 5-fluoro-2'-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells.

  Cancer research 20040915

• Cytotoxic chemotherapy for metastatic renal cell carcinoma.

  Der Urologe. Ausg. A 20040901

• A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.

  International journal of oncology 20040901

• Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition.

  Molecular pharmacology 20040901

• [The association of expression and gene polymorphism of the thymidylate synthase gene with 5-fluoro-5'-deoxyuridine sensitivity in gastric cancer cell lines].

  Gan to kagaku ryoho. Cancer & chemotherapy 20040901

• [A long-surviving patient with Stage IV breast cancer with no recurrence after combined therapy of medroxy progesterone acetate (MPA) and intra-arterial infusion chemotherapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20040901

• [The effect of pre-operative chemotherapy on calpain in cells of gastrointestinal malignant tumors].

  Zhonghua wai ke za zhi [Chinese journal of surgery] 20040807

• Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients.

  Pharmacological research 20040801

• Effects of oxaliplatin and CPT-11 on cytotoxicity and nucleic acid incorporation of the fluoropyrimidines.

  Journal of cancer research and clinical oncology 20040801

• Hepatic arterial infusion chemotherapy for metastatic colorectal cancer: a concise overview.

  Cancer treatment reviews 20040801

• In vitro and in vivo antitumor activity of novel amphiphilic dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine.

  International journal of oncology 20040801

• Hepatic artery infusion chemotherapy for metastatic colorectal cancer to the liver at the lahey clinic: comparison between two methods of treatment, surgical versus percutaneous catheter placement.

  American journal of clinical oncology 20040801

• [Enhancement effect of interferon gamma on the sensitivity of RT4 bladder cancer cells to 5'-deoxy-5-fluorouridine,and 5-fluorouracil through up-regulation of PD-ECGF/TP].

  Ai zheng = Aizheng = Chinese journal of cancer 20040801

• [A case of liver metastasis of colon cancer responding remarkably to 5'-DFUR].

  Gan to kagaku ryoho. Cancer & chemotherapy 20040801

• Dihydropyrimidine dehydrogenase deficiency: impact of pharmacogenetics on 5-fluorouracil therapy.

  Clinical advances in hematology & oncology : H&O 20040801

• The HPV16 E6/E7 oncogene sensitizes human ovarian surface epithelial cells to low-dose but not high-dose 5-FU and 5-FUdR.

  Biochemical and biophysical research communications 20040716

• Thymidylate synthase inhibition triggers glucose-dependent apoptosis in p53-negative leukemic cells.

  FEBS letters 20040716

• The ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase in tumour tissues of patients with metastatic gastric cancer is predictive of the clinical response to 5'-deoxy-5-fluorouridine.

  European journal of cancer (Oxford, England : 1990) 20040701

• Prediction of 5'-deoxy-5-fluorouridine sensitivity in colorectal cancer cases by thymidine phosphorylase activity and preliminary identification of susceptibility related genes.

  Oncology reports 20040701

• Bioactivation of capecitabine in human liver: involvement of the cytosolic enzyme on 5'-deoxy-5-fluorocytidine formation.

  Drug metabolism and disposition: the biological fate of chemicals 20040701

• Doxifluridine-induced neurotoxicity with normal dihydropyrimidine dehydrogenase activity.

  Neurology 20040608

• Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice.

  International journal of oncology 20040601

• Complications after percutaneous transaxillary implantation of a catheter for intraarterial chemotherapy of liver tumors: clinical relevance and management in 204 patients.

  AJR. American journal of roentgenology 20040601

• Gemcitabine in patients with solid tumors and renal impairment: a pharmacokinetic phase I study.

  American journal of clinical oncology 20040601

• Intra-aortal therapy with 5-fluorouracil- polyethylene glycol stealth liposomes: does the metabolism of 5-fluorouracil into 5-fluoro-2'-deoxyuridine depend on ph value?. An animal study in VX-2 liver tumor-bearing rabbits.

  Chemotherapy 20040601

• Floxuridine-containing regimens in the treatment of gestational trophoblastic tumor.

  The Journal of reproductive medicine 20040601

• Highly efficient DNA incorporation of intratumourally injected [125I]iododeoxyuridine under thymidine synthesis blocking in human glioblastoma xenografts.

  International journal of cancer 20040520

• Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer.

  Journal of the National Cancer Institute 20040519

• [Thymidine phosphorylase expressed in monocyte-macrophages enhanced anticancer effect of 5'-deoxy-5-fluorouridine on colorectal carcinoma cells].

  Zhonghua yi xue za zhi 20040502

• Comparison of intraperitoneal continuous infusion of floxuridine and bolus administration in a peritoneal gastric cancer xenograft model.

  Cancer chemotherapy and pharmacology 20040501

• Defining the role of hepatic arterial infusion chemotherapy in metastatic colorectal cancer.

  Oncology (Williston Park, N.Y.) 20040501

• S-1-induced, prolonged complete regression of lung metastasis from gastric cancer refractory to 5'-DFUR: a case report with pharmacokinetic study.

  Japanese journal of clinical oncology 20040501

• Uridine phosophorylase: an important enzyme in pyrimidine metabolism and fluoropyrimidine activation.

  Drugs of today (Barcelona, Spain : 1998) 20040501

• Translocation (11;13)(q23;q14) as the sole abnormality in a childhood de novo acute myelocytic leukemia.

  Cancer genetics and cytogenetics 20040401

• Interactions of nucleoside analogs, caffeine, and nicotine with human concentrative nucleoside transporters 1 and 2 stably produced in a transport-defective human cell line.

  Molecular pharmacology 20040401

• Regional chemotherapeutic techniques for liver tumors: current knowledge and future directions.

  The Surgical clinics of North America 20040401

• [A case of advanced gastric cancer successfully treated with neoadjuvant chemotherapy of combined weekly paclitaxel and doxifluridine (5'-DFUR)].

  Gan to kagaku ryoho. Cancer & chemotherapy 20040401

• Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents.

  Journal of medicinal chemistry 20040325

• [Two cases of metastatic or recurrent rectal cancer responding to combined chemotherapy of low-dose CPT-11 and 5'-DFUR as second-line chemotherapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20040301

• [Immunotherapy of metastatic renal cell carcinoma: report of 28 cases].

  Zhonghua wai ke za zhi [Chinese journal of surgery] 20040222

• In vitro and in vivo evaluation of novel antitumor prodrugs of 5-fluoro-2'-deoxyuridine activated by hypoxic irradiation.

  International journal of radiation oncology, biology, physics 20040201

• [A case of 10-year survival after combination chemotherapy of 5'-deoxy-5-fluorouridine and cisplatin and adjuvant surgery for gastric cancer with liver metastasis].

  Gan to kagaku ryoho. Cancer & chemotherapy 20040201

• Correlation of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase with sensitivity of gastrointestinal cancer cells to 5-fluorouracil and 5-fluoro-2'-deoxyuridine.

  World journal of gastroenterology 20040115

• Enzyme-prodrug systems: thymidine phosphorylase/5'-deoxy-5-fluorouridine.

  Methods in molecular medicine 20040101

• In vivo comparison of IVDU and IVFRU in HSV1-TK gene expressing tumor bearing rats.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20040101

• Effects of dexamethasone or celecoxib on biliary toxicity after hepatic arterial infusion of 5-fluorodeoxyuridine in a canine model.

  Cancer research 20040101

• Thymidylate synthetase mRNA levels are increased in liver metastases of colorectal cancer patients resistant to fluoropyrimidine-based chemotherapy.

  BMC cancer 20040101

• The role of radiotherapy in the treatment of liver metastases.

  Cancer journal (Sudbury, Mass.) 20040101

• Validated procedure for simultaneous trace level determination of the anti-cancer agent gemcitabine and its metabolite in human urine by high-performance liquid chromatography with tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20040101

• The comet assay differentiates efficiently and rapidly between genotoxins and cytotoxins in quiescent cells.

  Cell biology international 20040101

• Oral 5-FU is a more effective antimetastatic agent than UFT.

  Anticancer research 20040101

• Combination chemotherapy with docetaxel and doxifluridine showed a beneficial outcome in advanced or recurrent breast cancer patients with longer disease-free interval.

  Anticancer research 20040101

• A randomized controlled study of immunochemotherapy with OK-432 after curative surgery for gastric cancer.

  Journal of immunotherapy (Hagerstown, Md. : 1997) 20040101

• Randomized phase II study comparing mitomycin, cisplatin plus doxifluridine with cisplatin plus doxifluridine in advanced unresectable gastric cancer.

  Anticancer research 20040101

• Role of DNA mismatch repair in apoptotic responses to therapeutic agents.

  Environmental and molecular mutagenesis 20040101

• [Antisense oligonucleotides with antitumor activity].

  Magyar onkologia 20040101

• Comparative antitumor activity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in combination with interferon-alpha in renal cell carcinoma cell lines.

  Urologia internationalis 20040101

• Fixation methods for implantable port chamber: comparative study using glue, self-stabilizing leg and suture fixations in rabbits.

  Korean journal of radiology 20040101

• Novel prophylactic effect of doxifluridine in superficial bladder cancer.

  Scandinavian journal of urology and nephrology 20040101

• A phase I and pharmacologic study of weekly gemcitabine in combination with infusional 5-fluorodeoxyuridine and oral calcium leucovorin.

  Cancer chemotherapy and pharmacology 20031201

• [A case of breast cancer with lung and bone metastasis treated successfully by oral combination chemotherapy of 5'-deoxy-5-fluorouridine and cyclophosphamide].

  Gan to kagaku ryoho. Cancer & chemotherapy 20031201

• In vivo monitoring of capecitabine metabolism in human liver by 19fluorine magnetic resonance spectroscopy at 1.5 and 3 Tesla field strength.

  Cancer research 20031115

• The potential for oral combination chemotherapy of 5'-deoxy-5-fluorouridine, a 5-FU prodrug, and cyclophosphamide for metastatic breast cancer.

  British journal of cancer 20031103

• Comparative study of three methods for non-radioactive in vivo DNA labeling in Escherichia coli using nucleoside analogs.

  Preparative biochemistry & biotechnology 20031101

• [A case of advanced breast cancer with multiple lung, bone and lymph node metastases successfully treated with 5'-DFUR alone].

  Gan to kagaku ryoho. Cancer & chemotherapy 20031101

• [Concomitant whole brain radiotherapy and FUDR+VM-26+DDP chemotherapy in brain metastasis of non-small cell lung cancer: a report of short term efficacy].

  Zhongguo fei ai za zhi = Chinese journal of lung cancer 20031020

• One-electron reduction characteristics of N(3)-substituted 5-fluorodeoxyuridines synthesized as radiation-activated prodrugs.

  Bioorganic & medicinal chemistry 20031015

• ZD1839 (Iressa) modifies the activity of key enzymes linked to fluoropyrimidine activity: rational basis for a new combination therapy with capecitabine.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20031015

• An expedient assay for determination of gemcitabine and its metabolite in human plasma using isocratic ion-pair reversed-phase high-performance liquid chromatography.

  Therapeutic drug monitoring 20031001

• Review article: colorectal cancer chemotherapy.

  Alimentary pharmacology & therapeutics 20031001

• [A case of multiple liver metastases of colon cancer with PyNPase-positive successfully treated with 5'-DFUR].

  Gan to kagaku ryoho. Cancer & chemotherapy 20031001

• [A case of hepatic metastasis and local recurrence from rectal cancer responding to hepatic arterial infusion and systemic chemotherapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20031001

• Can colorectal cancer patients with thymidylate synthase-overexpressing liver metastases have an overall survival advantage with hepatic arterial infusion alone?

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030915

• 5'-(2-Nitrophenylalkanoyl)-2'-deoxy-5-fluorouridines as potential prodrugs of FUDR for reductive activation.

  Bioorganic & medicinal chemistry 20030901

• Combination of TRAIL gene therapy and chemotherapy enhances antitumor and antimetastasis effects in chemosensitive and chemoresistant breast cancers.

  Molecular therapy : the journal of the American Society of Gene Therapy 20030901

• Phase I/II study of hepatic arterial therapy with floxuridine and dexamethasone in combination with intravenous irinotecan as adjuvant treatment after resection of hepatic metastases from colorectal cancer.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030901

• [PyNPase and DPD expression potentially predict response to 5'-DFUR treatment for node-positive breast cancer patients].

  Gan to kagaku ryoho. Cancer & chemotherapy 20030901

• Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis.

  Pharmaceutical research 20030901

• [Doxifluridine for treatment of colorectal cancer].

  Nihon rinsho. Japanese journal of clinical medicine 20030901

• [Clinical evaluation of integration of transcatheter arterial chemoembolization and traditional Chinese medicine in treating metastatic liver cancer].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20030901

• Correlation between 5-fluorouracil metabolism and treatment response in two variants of C26 murine colon carcinoma.

  British journal of cancer 20030818

• MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine.

  The Journal of biological chemistry 20030808

• Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans.

  Chembiochem : a European journal of chemical biology 20030804

• Multidetector CT arteriography with volumetric three-dimensional rendering to evaluate patients with metastatic colorectal disease for placement of a floxuridine infusion pump.

  AJR. American journal of roentgenology 20030801

• Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum.

  Biochemical and biophysical research communications 20030801

• [A case of multiple lung metastases of colon cancer with long-term survival following 5'-DFUR and cimetidine therapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20030801

• Intraperitoneal therapy as consolidation for patients with ovarian cancer and negative reassessment after platinum-based chemotherapy.

  Hematology/oncology clinics of North America 20030801

• [Floxuridine-containing regime in the treatment of gestational trophoblastic tumor].

  Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20030801

• Pharmacokinetics of 5-fluorouracil following hepatic intra-arterial infusion in a VX2 hepatic metastasis model.

  Japanese journal of clinical oncology 20030801

• Functional analysis of the EWS/ETS target gene uridine phosphorylase.

  Cancer research 20030715

• A randomized controlled trial of postoperative adjuvant immunochemotherapy for colorectal cancer with oral medicines.

  International journal of oncology 20030701

• Adjuvant hepatic arterial chemotherapy following metastasectomy in patients with isolated liver metastases.

  Annals of surgery 20030601

• [A case of liver metastasis of colon cancer demonstrating complete remission with combination chemotherapy of 5'-DFUR and MMC].

  Gan to kagaku ryoho. Cancer & chemotherapy 20030601

• [Effect of preoperative oral 5'-DFUR on PyNPase level in gastrointestinal malignant tumor tissues].

  Ai zheng = Aizheng = Chinese journal of cancer 20030601

• [18F]5-fluoro-2-deoxyuridine-PET for imaging of malignant tumors and for measuring tissue proliferation.

  Cancer biotherapy & radiopharmaceuticals 20030601

• IPM chemotherapy in cytokine refractory renal cell cancer.

  British journal of cancer 20030519

• Hepatic artery chemotherapy and colorectal liver metastases.

  Lancet (London, England) 20030517

• Hepatic artery chemotherapy and colorectal liver mestastases.

  Lancet (London, England) 20030517

• [Evaluation of weekly paclitaxel and doxifluridine (5'-DFUR) combination therapy in patients with advanced or recurrent breast cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20030501

• [Oral combination chemotherapy of 5'-deoxy-5-fluorouridine (furtulon) and cyclophosphamide for advanced breast cancer].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20030501

• Formation of electrically active clusterized neural networks.

  Physical review letters 20030425

• Effects of introduction of dThdPase cDNA on sensitivity to 5'-deoxy-5-fluorouridine and tumor angiogenesis.

  International journal of oncology 20030401

• A 'combination oligonucleotide' antisense strategy to downregulate thymidylate synthase and decrease tumor cell growth and drug resistance.

  Cancer gene therapy 20030401

• Massive mucinous carcinoma of the breast untreated for 6 years.

  International journal of clinical oncology 20030401

• Preparation and characterization of chitosan microspheres containing doxifluridine.

  Drug development and industrial pharmacy 20030401

• Nonsteroidal anti-inflammatory drugs in colorectal cancer: from prevention to therapy.

  British journal of cancer 20030324

• Randomized controlled trial comparing oral doxifluridine plus oral cyclophosphamide with doxifluridine alone in women with node-positive breast cancer after primary surgery.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030315

• Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: 'nitric oxide donor' agents for evaluation as anticancer and antiviral agents.

  Journal of medicinal chemistry 20030313

• Penetration of capecitabine and its metabolites into malignant and healthy tissues of patients with advanced breast cancer.

  British journal of cancer 20030310

• Population pharmacokinetics and concentration-effect relationships of capecitabine metabolites in colorectal cancer patients.

  British journal of clinical pharmacology 20030301

• Preclinical Auger and gamma radiation dosimetry for fluorodeoxyuridine-enhanced tumour proliferation scintigraphy with [123I]iododeoxyuridine.

  European journal of nuclear medicine and molecular imaging 20030201

• Subconjunctival doxifluridine administration suppresses rat choroidal neovascularization through activated thymidine phosphorylase.

  Investigative ophthalmology & visual science 20030201

• Hepatic artery infusion for liver metastases from colorectal cancer.

  Lancet (London, England) 20030201

• Oral doxifluridine plus leucovorin in metastatic colorectal cancer: randomized phase II trial with intravenous 5-fluorouracil plus leucovorin.

  American journal of clinical oncology 20030201

• [Optimal dosing schedule in combination therapy with irinotecan and doxifluridine in a human colorectal cancer xenograft model].

  Gan to kagaku ryoho. Cancer & chemotherapy 20030201

• [A case of advanced recurrent breast cancer responding to treatment with weekly docetaxel combined with doxorubicin].

  Gan to kagaku ryoho. Cancer & chemotherapy 20030201

• Effects of chlorin-mediated photodynamic therapy combined with fluoropyrimidines in vitro and in a patient.

  Cancer chemotherapy and pharmacology 20030201

• Laparoscopic radiofrequency ablation and hepatic artery infusion pump placement in the evolving treatment of colorectal hepatic metastases.

  Surgical endoscopy 20030101

• Detection of thymidylate synthase modulators by a novel screening assay.

  Molecular pharmacology 20030101

• The mechanism of action of radiosensitization of conventional chemotherapeutic agents.

  Seminars in radiation oncology 20030101

• Technical complications of continuous intra-arterial chemotherapy with 5-fluorodeoxyuridine and 5-fluorouracil for colorectal liver metastases.

  Surgery 20030101

• [The role of the regional (intra-arterial) chemotherapy in the treatment of hepatic metastases of colorectal cancer].

  Medicina (Kaunas, Lithuania) 20030101

• Recombinant leukocyte interferon, doxorubicin, and 5FUDR in patients with hepatocellular carcinoma-A phase II trial.

  Journal of cancer research and clinical oncology 20030101

• Depression of phenytoin metabolic capacity by 5-fluorouracil and doxifluridine in rats.

  The Journal of pharmacy and pharmacology 20030101

• In vitro studies on the immunosuppressive effect of 2',2'-difluorodeoxycytidine (dFdC) and its metabolite 2',2'-difluorodeoxyuridine (dFdU).

  Immunobiology 20030101

• Randomised double blind placebo control study of adjuvant treatment with the metalloproteinase inhibitor, Marimastat in patients with inoperable colorectal hepatic metastases: significant survival advantage in patients with musculoskeletal side-effects.

  Anticancer research 20030101

• Thymidine phosphorylase expressed in macrophages enhances antitumor effect of 5'-deoxy-5-fluorouridine on human colorectal carcinoma cells.

  Anticancer research 20030101

• Arterial chemotherapy as adjuvant and palliative treatment of hepatic colorectal metastases: an update.

  Surgical oncology clinics of North America 20030101

• Induction of thymidine phosphorylase expression by Taxol does not enhance Furtulon sensitivity in a cisplatin-resistant human ovarian carcinoma cell line.

  Anticancer research 20030101

• Totally implantable arterial device (TIAD): a questionable complication.

  Hepato-gastroenterology 20030101

• Thymidine phosphorylase expression correlates with malignant potential and anti-tumor effect of doxifluridine on gastric cancer: multivariate analysis for adjuvant chemotherapy doxifluridine vs. 5-fluorouracil.

  Oncology reports 20030101

• Clinical efficacy of doxifluridine and correlation to in vitro sensitivity of anticancer drugs in patients with colorectal cancer.

  Anticancer research 20030101

• Induction of thymidine phosphorylase expression and enhancement of Furtulon sensitivity by Taxol in a human ovarian carcinoma cell line.

  Anticancer research 20030101

• Hepatic artery embolization and chemoembolization for treatment of patients with metastatic carcinoid tumors: the M.D. Anderson experience.

  Cancer journal (Sudbury, Mass.) 20030101

• Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors.

  Nucleosides, nucleotides & nucleic acids 20030101

• A new class of Spiegelmers containing 2'-fluoro-nucleotides.

  Nucleosides, nucleotides & nucleic acids 20030101

• Synthesis and physicochemical characteristics of a liver-targeted conjugate of fluorodeoxyuridine monophosphate with lactosaminated human albumin.

  Rapid communications in mass spectrometry : RCM 20030101

• A case of chest wall recurrence of breast cancer treated with paclitaxel weekly, 5'-deoxy-5-fluorouridine, arterial embolization and chest wall resection.

  Breast cancer (Tokyo, Japan) 20030101

• Conformal chemoradiation for primary and metastatic liver malignancies.

  Seminars in surgical oncology 20030101

• Combination effects of Ara-C and 5-fluorodeoxyuridine against leukemia cells in vitro and in mice.

  Anticancer research 20030101

• Positive response to oral chemoendocrine combination therapy using 5'-deoxy-5-fluorouridine for locally advanced breast cancer with carcinomatous pleurisy: report of a case.

  Surgery today 20030101

• Induction chemotherapy followed by hyperfractionated radiotherapy with concurrent chemotherapy for locally advanced head and neck cancer.

  Anticancer research 20030101

• Bone morphogenetic protein-6 is a neurotrophic factor for calbindin-positive striatal neurons.

  Journal of neuroscience research 20021201

• Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human liver.

  Cancer chemotherapy and pharmacology 20021201

• Role of thymidine phosphorylase and dihydropyrimidine dehydrogenase in tumour progression and sensitivity to doxifluridine in gastric cancer patients.

  European journal of cancer (Oxford, England : 1990) 20021201

• Penetration of capecitabine and its metabolites into malignant and healthy tissue of patients with advanced breast cancer.

  International journal of clinical pharmacology and therapeutics 20021201

• Enhanced brain targeting by synthesis of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine and incorporation into solid lipid nanoparticles.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20021101

• External genital warts: diagnosis, treatment, and prevention.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021015

• Serotonergic stimulation of corticotropin-releasing hormone and pro-opiomelanocortin gene expression.

  Journal of neuroendocrinology 20021001

• [A case of colon metastasis to the lung treated successfully with combined chemotherapy of CPT-11 and 5'-DFUR].

  Gan to kagaku ryoho. Cancer & chemotherapy 20021001

• [Phenomenon of pseudomutagenesis: experiments with modifiers of cell metabolism in human lymphocytes].

  Genetika 20021001

• Correlation of p53 immunostaining in primary and residual ovarian cancer at the time of positive second-look laparotomy and its prognostic role: a Southwest Oncology Group ancillary study.

  Gynecologic oncology 20021001

• Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine.

  The Journal of biological chemistry 20020927

• A 5-fluorodeoxyuridine prodrug as targeted therapy for prostate cancer.

  Bioorganic & medicinal chemistry letters 20020902

• [Chemotherapy of gastric cancer--a review of clinical trials in Japan].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020901

• [A case of recurrent gastric cancer that responded dramatically to docetaxel and 5'-DFUR combination chemotherapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020901

• The means to an end of tumor cell resistance to chemotherapeutic drugs targeting thymidylate synthase: shoot the messenger.

  Current drug targets 20020801

• [A case of multiple skin metastases from gastric cancer successfully treated with docetaxel combined with doxifluridine].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020801

• Comparison of 5-fluorouracil and 5-fluoro-2'-deoxyuridine as an effector in radiation-activated prodrugs.

  Journal of chemotherapy (Florence, Italy) 20020801

• Analysis of radiation-induced liver disease using the Lyman NTCP model.

  International journal of radiation oncology, biology, physics 20020715

• Quantification of 2'-fluoro-2'-deoxyuridine and 2'-fluoro-2'-deoxycytidine in DNA and RNA isolated from rats and woodchucks using LC/MS/MS.

  Chemical research in toxicology 20020701

• Searching limiting steps in the expression of chloroplast-encoded proteins: relations between gene copy number, transcription, transcript abundance and translation rate in the chloroplast of Chlamydomonas reinhardtii.

  The Plant journal : for cell and molecular biology 20020701

• [Assessment of complications in a randomized controlled study on multimodality therapy for patients following breast-conserving surgery: Kansai Breast Cancer Radiotherapy Research Group (5'-KBR)].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020701

• [One case of locally advanced breast cancer in which multidisciplinary treatment, chiefly, therapy with preoperative intraarterial infusion of docetaxel (TXT), was successful].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020701

• Expression of extracellular signal-regulated kinase and its relationship with clinicopathological characteristics of breast cancer.

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20020701

• Preoperative chemoradiation in patients with resectable rectal cancer: results on tumor response.

  Annals of surgical oncology 20020601

• [A case of colon cancer with multiple liver metastases and lymph nodes metastases successfully treated by 5'-deoxy-5-fluorouridine].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020601

• Floxuridine coupling with lactosaminated human albumin to increase drug efficacy on liver micrometastases.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20020601

• Conjugates of nucleoside analogs with lactosaminated human albumin to selectively increase the drug levels in liver blood: requirements for a regional chemotherapy.

  The Journal of pharmacology and experimental therapeutics 20020501

• Probable metabolic interaction of doxifluridine with phenytoin.

  The Annals of pharmacotherapy 20020501

• [A case of breast cancer with multiple bone metastases that responded remarkably to doxifluridine (5'-DFUR), cyclophosphamide (CPA), medroxyprogesterone acetate (MPA) and pamidronate disodium therapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020501

• [The antitumor activity of DPD inhibitory-fluoropyrimidine (DIF) and non-DIF alone or in combination with paclitaxel against orthotopically implanted human breast cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020501

• Metastatic urothelial cancer showing an efficacy by low-dose cisplatin.

  International journal of urology : official journal of the Japanese Urological Association 20020501

• Thymidine phosphorylase activity in renal cell carcinoma: relationship between histological parameters and chemosensitivity to fluorouracil-related drugs.

  Urological research 20020501

• Covalent analogues of DNA base-pairs and triplets. Part 2: synthesis and cytostatic activity of bis(purin-6-yl)acetylenes,-diacetylenes and related compounds.

  Bioorganic & medicinal chemistry letters 20020408

• Impact of the oxaliplatin-5 fluorouracil-folinic acid combination on respective intracellular determinants of drug activity.

  British journal of cancer 20020408

• Downstaging of hepatocellular carcinoma and liver metastases from colorectal cancer by selective intra-arterial chemotherapy.

  Surgery 20020401

• Intrahepatic arterial infusion of chemotherapy: pharmacologic principles.

  Seminars in oncology 20020401

• Intrahepatic arterial infusion of chemotherapy: clinical results.

  Seminars in oncology 20020401

• [A case report of effective chemoradiation with 5'-DFUR and concomitant preoperative radiotherapy of the lower rectum].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020401

• Prognostic and predictive value of thymidine phosphorylase activity in early-stage breast cancer patients.

  Clinical breast cancer 20020401

• Combined-modality treatment for resectable metastatic colorectal carcinoma to the liver: surgical resection of hepatic metastases in combination with continuous infusion of chemotherapy--an intergroup study.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020315

• Echogenicity of liver metastases from colorectal carcinoma is an independent prognostic factor in patients treated with regional chemotherapy.

  Cancer 20020315

• The effect of adjuvant 5'-deoxy-5-fluorouridine in early stage breast cancer patients: results from a multicenter randomized controlled trial.

  International journal of oncology 20020301

• Fighting wars, winning battles.

  Annals of surgical oncology 20020301

• Systemic irinotecan and regional floxuridine after hepatic cytoreduction in 185 patients with unresectable colorectal cancer metastases.

  Annals of surgical oncology 20020301

• [Successful treatment of advanced recurent breast cancer using DMpC therapy as maintenance therapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020301

• Overexpression of pyrimidine nucleoside phosphorylase enhances the sensitivity to 5'-deoxy-5-fluorouridine in tumour cells in vitro and in vivo.

  European journal of cancer (Oxford, England : 1990) 20020301

• A phase II study of doxifluridine in elderly patients with advanced gastric cancer: the Japan Clinical Oncology Group Study (JCOG 9410).

  Japanese journal of clinical oncology 20020301

• Biochemical and molecular effects of UCN-01 in combination with 5-fluorodeoxyuridine in A431 human epidermoid cancer cells.

  Anti-cancer drugs 20020301

• CT-guided intratumoural administration of cisplatin/epinephrine gel for treatment of malignant liver tumours.

  British journal of cancer 20020212

• [Evidence for and practical use of arterial infusion chemotherapy for liver metastases].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020201

• [A case of long surviving advanced recurrent breast cancer with multiple bone metastases responding to treatment with 5'-DFUR combined with MPA].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020201

• A controlled 'before-after' study: impact of a clinical guidelines programme and regional cancer network organization on medical practice.

  British journal of cancer 20020201

• Sciatic conditioned medium increases survival, proliferation and differentiation of retinal cells in culture.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20020201

• Thymidylate Synthase expression as a predictor of clinical response to fluoropyrimidine-based chemotherapy in advanced colorectal cancer.

  Cancer treatment reviews 20020201

• Immunohistochemical variation of human equilibrative nucleoside transporter 1 protein in primary breast cancers.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020101

• Use of 5-[(76)Br]bromo-2'-fluoro-2'-deoxyuridine as a ligand for tumour proliferation: validation in an animal tumour model.

  European journal of nuclear medicine and molecular imaging 20020101

• [A 5'-DFUR + CPA + THP therapy that was effective for paclitaxel-refractory pulmonary metastasis of breast cancer--a case report].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020101

• [Adjuvant chemotherapy after curative resection for gastric cancer-5'-DFUR + cisplatin vs 5'-DFUR].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020101

• [Antimetastatic and antitumor effects of fluoropyrimidines alone and combined with taxanes in a murine model of breast cancer metastatic to the lung].

  Gan to kagaku ryoho. Cancer & chemotherapy 20020101

• Treatment of patients with superficial bladder cancer by intravesical instillation of anticancer drugs plus oral chemotherapy following TUR-Bt: a randomized controlled trial.

  Oncology reports 20020101

• Thymidine phosphorylase and dihydropyrimidine dehydrogenase levels in primary colorectal cancer show a relationship to clinical effects of 5'-deoxy-5-fluorouridine as adjuvant chemotherapy.

  Oncology reports 20020101

• Circadian chemotherapy for gynecological and genitourinary cancers.

  Chronobiology international 20020101

• Schedule-selective biochemical modulation of 5-fluorouracil in advanced colorectal cancer--a phase II study.

  BMC cancer 20020101

• Neoadjuvant chemotherapy with CPT-11 and cisplatin downstages locally advanced gastric cancer.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20020101

• Percutaneous vs. surgical placement of hepatic artery indwelling catheters for regional chemotherapy.

  Hepato-gastroenterology 20020101

• Isolation perfusion of the liver.

  Cancer journal (Sudbury, Mass.) 20020101

• Postoperative adjuvant chemotherapy is effective in gastric cancer with serosal invasion: significance in patients chosen for multivariate analysis.

  Oncology reports 20020101

• Hepatic artery infusion of chemotherapy as a treatment for hepatic metastases from colorectal cancer.

  Cancer journal (Sudbury, Mass.) 20020101

• Combined surgical-percutaneous approach for placement of arterial devices for hepatic chemotherapy.

  Hepato-gastroenterology 20020101

• Prolonged exposure of chromaffin cells to nitric oxide down-regulates the activity of soluble guanylyl cyclase and corresponding mRNA and protein levels.

  BMC biochemistry 20020101

• Potent antitumor effect of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine on peritoneal dissemination models of gastrointestinal cancers.

  Oncology reports 20020101

• Efficient intracellular delivery of 5-fluorodeoxyuridine into colon cancer cells by targeted immunoliposomes.

  Cancer detection and prevention 20020101

• Effectiveness of doxifluridine (5'-DFUR)/docetaxel against advanced/recurrent gastric cancer showing resistance to various anticancer drug regimens.

  Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20020101

• IFN gamma-induced up-regulation of PD-ECGF/TP enhances the cytotoxicity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in bladder cancer cells.

  Anticancer research 20020101

• [Reorganization of DNA replicating system induced by 5-fluorodeoxyuridine and caffeine as the basis for radiosensitivity in human calls].

  Tsitologiia 20020101

• Comparative antitumor activity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in combination with interferon gamma in renal cell carcinoma cell lines.

  Anticancer research 20020101

• [Impact of preoperative locoregional chemotherapy with fluorodeoxyuridine on the outcome of liver resection].

  Chirurgia italiana 20020101

• Mechanisms of cell death induced by 5-fluoro-2'-deoxyuridine (FUdR)--necrosis or apoptosis after treated with FUdR.

  Nucleic acids research. Supplement (2001) 20020101

• Synthesis and biological studies of novel nucleoside phosphoramidate prodrugs.

  Journal of medicinal chemistry 20011206

• Antisense-induced down-regulation of thymidylate synthase and enhanced cytotoxicity of 5-FUdR in 5-FUdR-resistant HeLa cells.

  British journal of pharmacology 20011201

• Regional chemotherapy of nonresectable colorectal liver metastases with mitoxantrone, 5-fluorouracil, folinic acid, and mitomycin C may prolong survival.

  Cancer 20011201

• Surgery as adjuvant therapy? The treatment of peritoneal metastases from gastrointestinal malignancy.

  Annals of surgical oncology 20011201

• Surgical debulking and intraperitoneal chemotherapy for established peritoneal metastases from colon and appendix cancer.

  Annals of surgical oncology 20011201

• Randomised trial of SIR-Spheres plus chemotherapy vs. chemotherapy alone for treating patients with liver metastases from primary large bowel cancer.

  Annals of oncology : official journal of the European Society for Medical Oncology 20011201

• Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates.

  Bioorganic & medicinal chemistry letters 20011105

• Acquisition of human concentrative nucleoside transporter 2 (hcnt2) activity by gene transfer confers sensitivity to fluoropyrimidine nucleosides in drug-resistant leukemia cells.

  Molecular pharmacology 20011101

• Fluorodeoxyuridine improves imaging of human glioblastoma xenografts with radiolabeled iododeoxyuridine.

  Cancer research 20011101

• P53 mutation and response to hepatic arterial floxuridine in patients with colorectal liver metastases.

  Journal of cancer research and clinical oncology 20011101

• Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine.

  Biological & pharmaceutical bulletin 20011101

• [Hepatic infusion of docetaxel using PEIT for a patient with stage IV breast cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20011101

• [A case of lung metastasis from colon cancer treated successfully with combined chemotherapy of CPT-11 and 5'-DFUR].

  Gan to kagaku ryoho. Cancer & chemotherapy 20011101

• Survival benefits of adjuvant chemotherapy with oral doxifluridine (5'-DFUR) following radiotherapy in patients with unresectable pancreatic cancer.

  Journal of surgical oncology 20011101

• Thymidylate synthase pharmacogenetics in colorectal cancer.

  Clinical colorectal cancer 20011101

• Thymidine phosphorylase expression is useful in selecting adjuvant chemotherapy for stage III gastric cancer.

  International journal of oncology 20011001

• [A patient with recurrent breast cancer whose liver metastasis regressed following combined use of weekly docetaxel and MPA.5'-DFUR].

  Gan to kagaku ryoho. Cancer & chemotherapy 20011001

• [Effect of peroral doxifluridine plus hepatic arterial infusion for synchronous liver metastasis of colorectal cancer--correlation with the expression of thymidine phosphorylase and dihydropyrimidine dehydrogenase in primary colorectal cancer lesions].

  Gan to kagaku ryoho. Cancer & chemotherapy 20011001

• Combined effects of docetaxel and fluoropyrimidines on tumor growth and expression of interleukin-6 and thymidine phosphorylase in breast cancer xenografts.

  Cancer chemotherapy and pharmacology 20011001

• Interaction of thymidylate synthase with the 5'-thiophosphates, 5'-dithiophosphates, 5'-H-phosphonates and 5'-S-thiosulfates of 2'-deoxyuridine, thymidine and 5-fluoro-2'-deoxyuridine.

  Biological chemistry 20011001

• [Study on brain targeting 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine pharmacosomes].

  Yao xue xue bao = Acta pharmaceutica Sinica 20011001

• Inhibition of thymidylate synthase activity by antisense oligodeoxynucleotide and possible role in thymineless treatment.

  Molecular pharmacology 20010901

• Three-dimensional organization of the hepatic microvasculature in hereditary hemorrhagic telangiectasia.

  Archives of pathology & laboratory medicine 20010901

• Variations in 5-fluorouracil concentrations of colorectal tissues as compared with dihydropyrimidine dehydrogenase (DPD) enzyme activities and DPD messenger RNA levels.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20010901

• [Combination chemotherapy of doxifluridine plus mitomycin C for colorectal lung metastasis--phase II study].

  Gan to kagaku ryoho. Cancer & chemotherapy 20010901

• Docetaxel alone or orally combined with 5-fluorouracil and its derivatives: effects on mouse mammary tumor cell line MM2 in vitro and in vivo.

  Anti-cancer drugs 20010901

• Impact of thymidine phosphorylase surexpression on fluoropyrimidine activity and on tumour angiogenesis.

  British journal of cancer 20010801

• Role of Bax in apoptosis of IL-3-dependent cells.

  Oncogene 20010727

• Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses.

  Cancer research 20010701

• Phase I and pharmacologic study of i.v. hydroxyurea infusion given with i.p. 5-fluoro-2'-deoxyuridine and leucovorin.

  Anti-cancer drugs 20010701

• [A phase I study of docetaxel (TXT) and doxifluridine (5'-DFUR) combination therapy in patients with advanced and recurrent breast cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20010701

• [The efficacy of combination chemotherapy of 5'-deoxy-5-fluorouridine (5'-DFUR), cyclophosphamide (CPA) and medroxyprogesterone acetate (MPA) for bone metastasis in breast cancer patients].

  Gan to kagaku ryoho. Cancer & chemotherapy 20010701

• Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug.

  Molecular pharmacology 20010601

• Preoperative chemoradiotherapy with oral doxifluridine plus low-dose oral leucovorin in unresectable primary rectal cancer.

  International journal of radiation oncology, biology, physics 20010601

• Intracavitary chemotherapy with 5-fluoro-2'-deoxyuridine (FdUrd) in malignant brain tumors.

  Japanese journal of clinical oncology 20010601

• [Optimization of the preparation of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine pharmacosomes using central composite design].

  Yao xue xue bao = Acta pharmaceutica Sinica 20010601

• Phase I study of hepatic arterial infusion of floxuridine and dexamethasone with systemic irinotecan for unresectable hepatic metastases from colorectal cancer.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010515

• In vivo evaluation of 5-[(18)F]fluoro-2'-deoxyuridine as tracer for positron emission tomography in a murine pancreatic cancer model.

  Cancer research 20010515

• Enhancement of sensitivity to capecitabine in human renal carcinoma cells transfected with thymidine phosphorylase cDNA.

  International journal of cancer 20010501

• Renal cell carcinoma.

  Current opinion in oncology 20010501

• Sequential intrahepatic and systemic fluoropyrimidine-based chemotherapy for metastatic colorectal cancer confined to the liver. A phase II study.

  Cancer chemotherapy and pharmacology 20010501

• Systemic irinotecan or regional floxuridine chemotherapy prolongs survival after hepatic cryosurgery in patients with metastatic colon cancer refractory to 5-fluorouracil.

  Clinical colorectal cancer 20010501

• Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections.

  Clinical microbiology reviews 20010401

• Progression and enhancement of metastatic potential after exposure of tumor cells to chemotherapeutic agents.

  Cancer research 20010401

• Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20010401

• Schedule dependency of antitumor activity in combination therapy with capecitabine/5'-deoxy-5-fluorouridine and docetaxel in breast cancer models.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20010401

• [Preoperative chemotherapy for advanced colorectal carcinomas--comparison of histological effect between 5'-DFUR + leucovorin tablet and 5'-DFUR alone].

  Gan to kagaku ryoho. Cancer & chemotherapy 20010401

• Therapeutic approaches to metastasis confined to the liver.

  Current oncology reports 20010301

• Coupling of 5-fluoro 2'-deoxyuridine to lactosaminated poly-l-lysine: an approach to a regional, non-invasive chemotherapy of liver micrometastases.

  Biochemical pharmacology 20010215

• Isolated hepatic perfusion for unresectable hepatic metastases from colorectal cancer.

  Surgery 20010201

• Combination of standard cytotoxic agents with polyamine analogues in the treatment of breast cancer cell lines.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20010201

• [Weekly low dose CPT-11 for multiple lung metastases of colon cancer on an out-patient treatment: a case report].

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20010201

• [Clinical evaluation of effects and improvement in quality of life from palliative therapy of combination chemotherapy with Furtulon and consecutive low-dose cisplatin in cases of unresectable advanced gastrointestinal carcinoma].

  Gan to kagaku ryoho. Cancer & chemotherapy 20010201

• [Advanced breast cancer with multiple bone metastases successfully treated with combined chemoendocrine-therapy of CEF (cyclophosphamide, epirubicin, 5-fluorouracil) and 5'-DFUR (5'-deoxy-5-fluorouridine) + MPA (medroxyprogesterone acetate)--a case report].

  Gan to kagaku ryoho. Cancer & chemotherapy 20010201

• Creation and characterization of 5-fluorodeoxyuridine-resistant Arg50 loop mutants of human thymidylate synthase.

  Cancer research 20010115

• Apoptosis of haematopoietic cells upon thymidylate synthase inhibition is independent of p53 accumulation and CD95-CD95 ligand interaction.

  The Biochemical journal 20010101

• The significance of thymidine phosphorylase expression in colorectal cancer.

  Oncology reports 20010101

• Reduced cellular transport and activation of fluoropyrimidine nucleosides and resistance in human lymphocytic cell lines selected for arabinosylcytosine resistance.

  Biochemical pharmacology 20010101

• 5'-deoxy-5-fluorouridine, medroxyprogestrone acetate and mitoxantrone hydrochloride for advanced or recurrent breast cancer.

  Breast cancer (Tokyo, Japan) 20010101

• Prognostic value of thymidine phosphorylase immunostaining in patients with uterine cervical cancer treated concurrently with doxifluridine, radiotherapy and immunotherapy.

  Oncology reports 20010101

• Effects of concomitant use of doxifluridine, radiotherapy and immunotherapy in patients with advanced cervical cancer.

  Oncology reports 20010101

• [Effectiveness of high-dose, intermittent 5'-DFUR therapy for advanced gastric cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20010101

• [Survival of 2 years and 7 months with 5'-DFUR treatment in a patient with peritoneal gastric cancer recurrence].

  Gan to kagaku ryoho. Cancer & chemotherapy 20010101

• Intravenous 5-fluorouracil versus oral doxifluridine as preoperative concurrent chemoradiation for locally advanced rectal cancer: prospective randomized trials.

  Japanese journal of clinical oncology 20010101

• A phase II trial of mitomycin C, 5'-deoxy-5-fluorouridine, etoposide and medroxyprogesterone acetate (McVD-MPA) as a salvage chemotherapy to anthracycline-resistant tumor in relapsed breast cancer and its mechanism(s) of antitumor action.

  Oncology reports 20010101

• Locoregional therapy for liver metastases from colorectal cancer: the possibilities of intraarterial chemotherapy, and new hepatic-directed modalities.

  Hepato-gastroenterology 20010101

• Thymidine phosphorylase expression and effect of doxifluridine: a phase II study.

  Oncology reports 20010101

• Bone morphogenetic protein-2, but not bone morphogenetic protein-7, promotes dendritic growth and calbindin phenotype in cultured rat striatal neurons.

  Neuroscience 20010101

• A randomized study comparing oral and standard regimens for metastatic breast cancer.

  Oncology reports 20010101

• Extrahepatic biliary stenoses after hepatic arterial infusion (HAI) of floxuridine (FUdR) for liver metastases from colorectal cancer.

  Hepato-gastroenterology 20010101

• Malnutrition and cachexia in ovarian cancer patients: pathophysiology and management.

  Anticancer research 20010101

• gamma-Hydroxybutyric acid and 5-fluorouracil, metabolites of UFT, inhibit the angiogenesis induced by vascular endothelial growth factor.

  Angiogenesis 20010101

• Complications of hepatic artery infusion: a review of 4580 reported cases.

  International journal of gastrointestinal cancer 20010101

• Synthesis and antitumor activities of novel pyrimidine derivatives of 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid and 4,5-didehydro-5,6- dideoxy-L-ascorbic acid.

  Journal of medicinal chemistry 20001214

• [A case of effective bisphosphonate therapy of sequential pamidronate and incadronate for bone metastases from breast cancer].

  Gan to kagaku ryoho. Cancer & chemotherapy 20000801

• A rapid phenotypic assay for detection of acyclovir-resistant varicella-zoster virus with mutations in the thymidine kinase open reading frame.

  Antimicrobial agents and chemotherapy 20000401

• [Pain relief with alendronate therapy in a breast cancer patient with bone metastasis].

  Gan to kagaku ryoho. Cancer & chemotherapy 20000401

• Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells.

  British journal of pharmacology 19990801

• Anti-herpesvirus activities and cytotoxicities of 2-thiopyrimidine nucleoside analogues in vitro.

  Antiviral chemistry & chemotherapy 19990701

• Suppression of replication of multidrug-resistant HIV type 1 variants by combinations of thymidylate synthase inhibitors with zidovudine or stavudine.

  Molecular pharmacology 19990301

• Alternating floxuridine and 5-fluorouracil hepatic arterial chemotherapy for colorectal liver metastases minimizes biliary toxicity.

  American journal of surgery 19960901

• Use of floxuridine to modulate the antiviral activity of zidovudine.

  AIDS research and human retroviruses 19960720

• 2',3'-Didehydro-3'-deoxythymidine: regulation of its metabolic activation by modulators of thymidine-5'-triphosphate biosynthesis.

  Molecular pharmacology 19960701

• Epigenetic mechanisms of drug resistance: drug-induced DNA hypermethylation and drug resistance.

  Proceedings of the National Academy of Sciences of the United States of America 19930401

• The effects on toxicity of circadian patterning of continuous hepatic artery infusion.

  HPB surgery : a world journal of hepatic, pancreatic and biliary surgery 19920101

• Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride.

  Journal of medicinal chemistry 19910801

• Hepatobiliary toxicity of 5-fluoro-2'-deoxyuridine. Intra-arterial versus portal venous routes of infusion.

  Investigative radiology 19910501

• Complications of hepatic arterial infusion chemotherapy.

  Radiographics : a review publication of the Radiological Society of North America, Inc 19910101

• Fatty liver change as a result of hepatic artery infusion chemotherapy.

  American journal of clinical oncology 19900401

• Venoocclusive lesions of the central veins and portal vein radicles secondary to intraarterial 5-fluoro-2'-deoxyuridine infusion.

  Human pathology 19891201

• Toxoplasma gondii: the biochemical basis of resistance to emimycin.

  Experimental parasitology 19890801

• Floxuridine-induced sclerosing cholangitis: an ischemic cholangiopathy?

  Hepatology (Baltimore, Md.) 19890201

• [Computed tomographic and angiographic studies of arterial liver perfusion following intra-arterial infusion chemotherapy using 5-fluoro-2-deoxyuridine].

  Rontgen-Blatter; Zeitschrift fur Rontgen-Technik und medizinisch-wissenschaftliche Photographie 19890201

• Mutants of human colon adenocarcinoma, selected for thymidylate synthase deficiency.

  Proceedings of the National Academy of Sciences of the United States of America 19890201

• Floxuridine-associated sclerosing cholangitis. A dog model.

  Investigative radiology 19890101

• Intra-arterial hepatic chemotherapy for metastatic liver from colo-rectal carcinoma origin.

  Selective cancer therapeutics 19890101

• [Biliary and arterial obstructive processes in regional chemotherapy with FUDR].

  RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 19881101

• Effects of various nucleosides on antiviral activity and metabolism of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil against herpes simplex virus types 1 and 2.

  Antimicrobial agents and chemotherapy 19881001

• Drug-induced cholestasis.

  Bailliere's clinical gastroenterology 19880401

• Nonspecific corticosteroid therapy in patients receiving intra-arterial chemotherapy for hepatic metastases of colorectal origin.

  Cancer investigation 19880101

• 2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.

  Journal of medicinal chemistry 19870701

• In vitro and in vivo antiviral activity of 2'-fluorinated arabinosides of 5-(2-haloalkyl)uracil.

  Antiviral research 19870601

• Bile duct strictures associated with hepatic arterial infusion chemotherapy.

  Gastrointestinal radiology 19870101

• Sclerosing cholangitis from intraarterial floxuridine.

  Journal of clinical gastroenterology 19861201

• Fatal liver cirrhosis associated with long-term arterial infusion of floxuridine.

  Lancet (London, England) 19861115

• Hepatic arterial infusion with floxuridine and cisplatin: overriding importance of antitumor effect versus degree of tumor burden as determinants of survival among patients with colorectal cancer.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19860901

• Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.

  Journal of medicinal chemistry 19860701

• Phase II clinical evaluation of doxifluridine.

  Cancer treatment reports 19860601

• Wernicke-Korsakoff-like syndrome in patients with colorectal carcinoma treated with high-dose doxifluridine (5'-dFUrd).

  Acta neurologica Scandinavica 19860501

• Sclerosing cholangitis associated with hepatic arterial FUDR chemotherapy: radiographic-histologic correlation.

  AJR. American journal of roentgenology 19860401

• Cholecystitis secondary to infusion chemotherapy.

  Journal of surgical oncology 19860401

• Chemical cholecystitis after intrahepatic chemotherapy. The case for prophylactic cholecystectomy during pump placement.

  Diseases of the colon and rectum 19860301

• Interaction of monoclonal antibodies directed against bromodeoxyuridine with pyrimidine bases, nucleosides, and DNA.

  Journal of immunology (Baltimore, Md. : 1950) 19860301

• [Sclerosing cholangitis after chemotherapy by continuous hepatic intra-arterial infusion of fluorodeoxyuridine].

  Gastroenterologie clinique et biologique 19860201

• Biliary sclerosis associated with hepatic artery infusion of floxuridine.

  Surgery 19860101

• Common duct stricture associated with hepatic artery infusion of FUDR.

  Journal of surgical oncology 19860101

• Neurologic toxicity associated with hepatic artery infusion HAI of FUdR.

  Cancer chemotherapy and pharmacology 19860101

• Acute cholecystitis associated with hepatic arterial infusion of floxuridine.

  American journal of surgery 19851201

• Hepatic artery infusion chemotherapy for colorectal metastases: a personal experience.

  Journal of surgical oncology 19851101

• Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates.

  The Journal of biological chemistry 19850815

• Neurological manifestations in a phase 2 study of 13 patients treated with doxyfluridine.

  Acta neurologica Scandinavica 19850801

• Iatrogenic sclerosing cholangitis following hepatic arterial chemotherapy infusion.

  Radiology 19850801

• Cholangitis complicating intraarterial chemotherapy in liver metastasis.

  Radiology 19850801

• Hepatobiliary scintigraphy in patients receiving hepatic artery infusion chemotherapy.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 19850501

• Doxifluridine (5'-dFUrd) in patients with advanced colorectal carcinoma. A phase II study.

  Cancer chemotherapy and pharmacology 19850101

• Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine 'acyclic' nucleoside analogues.

  Journal of medicinal chemistry 19841101

• Chemical cholecystitis associated with hepatic artery infusion chemotherapy.

  AJR. American journal of roentgenology 19831001

• Antiherpes activity of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil and some other 5-substituted uracil arabinosyl nucleosides in two different cell lines.

  Antiviral research 19830901

• Long-term hepatic arterial infusion of 5-fluorodeoxyuridine for liver metastases using an implantable infusion pump.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19830501

• Carbocyclic analogues of 5-substituted uracil nucleosides: synthesis and antiviral activity.

  Journal of medicinal chemistry 19830201

• Synthesis and antiviral activity of 5-[(cyanomethylene)oxy]-2'-deoxyuridine.

  Journal of medicinal chemistry 19810401

• Improved synthesis and in vitro antiviral activities of 5-cyanouridine and 5-cyano-2'-deoxyuridine.

  Journal of medicinal chemistry 19770701

• Bioassay of alkyl halides and nucleotide base analogs by pulmonary tumor response in strain A mice.

  Cancer research 19750601

• Nucleosides. 3. Studies on 5-methylamino-2'-deoxyuridine as a specific antiherpes agent.

  Journal of medicinal chemistry 19660501