500-92-5 | Proguanil

Packsize	Purity	Availability	Price	Discounted Price
5mg	≥98%	in stock	$62.00	$44.00
250mg	≥97%	in stock	$86.00	$60.00
1g	≥97%	in stock	$213.00	$149.00
5g	95%	in stock	$946.00	$662.00
10g	≥97%	in stock	$965.00	$675.00
25g	≥97%	in stock	$1,715.00	$1,200.00

Description

• Catalog Number: AG21175
• Chemical Name: Proguanil
• CAS Number: 500-92-5
• Molecular Formula: C11H16ClN5
• Molecular Weight: 253.7312
• MDL Number: MFCD00866201
• SMILES: CC(NC(=N)NC(=N)Nc1ccc(cc1)Cl)C

Computed Properties

• Complexity: 292
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 4
• XLogP3: 1.5

Literature

• Quinolone-3-diarylethers: a new class of antimalarial drug.

  Science translational medicine 20130320

• Efficacy and safety of atovaquone-proguanil in treating imported malaria in Japan: the second report from the research group.

  Parasitology international 20120901

• A cluster of Plasmodium vivax malaria in an expedition group to Ethiopia: prophylactic efficacy of atovaquone/proguanil on liver stages of P. vivax.

  The Journal of infection 20120901

• Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene.

  Parasitology international 20120601

• Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K.

  The Journal of pharmacology and experimental therapeutics 20120601

• Standby emergency treatment of malaria in travelers: experience to date and new developments.

  Expert review of anti-infective therapy 20120501

• Dosing rationale for fixed-dose combinations in children: shooting from the hip?

  Clinical pharmacology and therapeutics 20120401

• Bridging strategies for drug combinations in pediatric indications.

  Clinical pharmacology and therapeutics 20120401

• Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression.

  The Journal of biological chemistry 20120323

• Mosquito infection studies with Aotus monkeys and humans infected with the Chesson strain of Plasmodiun vivax.

  The American journal of tropical medicine and hygiene 20120301

• Anti-malarial chemoprophylaxis following evacuation from Afghanistan.

  Journal of the Royal Army Medical Corps 20120301

• Prolonged protection provided by a single dose of atovaquone-proguanil for the chemoprophylaxis of Plasmodium falciparum malaria in a human challenge model.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120115

• Randomized, prospective, three-arm study to confirm the auditory safety and efficacy of artemether-lumefantrine in Colombian patients with uncomplicated Plasmodium falciparum malaria.

  The American journal of tropical medicine and hygiene 20120101

• Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria.

  Malaria journal 20120101

• Therapy of uncomplicated falciparum malaria in Europe: MALTHER - a prospective observational multicentre study.

  Malaria journal 20120101

• A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria.

  PloS one 20120101

• Focused Screening and Treatment (FSAT): a PCR-based strategy to detect malaria parasite carriers and contain drug resistant P. falciparum, Pailin, Cambodia.

  PloS one 20120101

• Review: Malaria chemoprophylaxis for travelers to Latin America.

  The American journal of tropical medicine and hygiene 20111201

• Malaria therapy in HIV: drug interactions between nevirapine and quinine.

  International journal of STD & AIDS 20111201

• [Atovaquone-proguanil treatment failure in Plasmodium falciparum].

  Presse medicale (Paris, France : 1983) 20111101

• Pharmacokinetics of antimalarials in pregnancy: a systematic review.

  Clinical pharmacokinetics 20111101

• Prophylactic use of antimalarials during pregnancy.

  Canadian family physician Medecin de famille canadien 20111101

• Prolonged administration of proguanil induces reproductive toxicity in male rats.

  The Journal of toxicological sciences 20111001

• Community management of anti-malarials in Africa and iatrogenic risk.

  Journal of tropical pediatrics 20110601

• Severe hypersensitivity reaction as acute eosinophilic pneumonia and skin eruption induced by proguanil.

  The European respiratory journal 20110601

• Improvements in compliance with medical force protection measures by simplification of the anti-malarial chemoprophylaxis regime.

  Journal of the Royal Army Medical Corps 20110601

• Exploring QSAR, pharmacophore mapping and docking studies and virtual library generation for cycloguanil derivatives as PfDHFR-TS inhibitors.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20110501

• Formation and identification of a degradant in chlorproguanil-dapsone-artesunate (Dacart™) tablets.

  Journal of pharmaceutical and biomedical analysis 20110220

• Azithromycin for treating uncomplicated malaria.

  The Cochrane database of systematic reviews 20110216

• Atovaquone-proguanil use in early pregnancy and the risk of birth defects.

  Archives of internal medicine 20110214

• [Post-malaria neurological syndrome complicating a relapse of Plasmodium falciparum malaria after atovaquone-proguanil treatment].

  Medecine et maladies infectieuses 20110101

• Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis.

  Malaria journal 20110101

• Fitness trade-offs in the evolution of dihydrofolate reductase and drug resistance in Plasmodium falciparum.

  PloS one 20110101

• Randomized trial of safety and effectiveness of chlorproguanil-dapsone and lumefantrine-artemether for uncomplicated malaria in children in the Gambia.

  PloS one 20110101

• Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials.

  Malaria journal 20110101

• Antimalarial chemoprophylaxis in a deployed Naval Unit.

  Journal of the Royal Naval Medical Service 20110101

• [Duodenal ulcers caused by chloroquine-proguanil association].

  Medecine tropicale : revue du Corps de sante colonial 20101201

• Localization of artesunate and its derivatives in the pregnant rat and fetus following oral administration and relationship to developmental toxicity.

  Birth defects research. Part B, Developmental and reproductive toxicology 20101001

• The rise and fall of the antimalarial Lapdap: a lesson in pharmacogenetics.

  Lancet (London, England) 20100828

• Pancytopenia due to proguanil toxicity in a returning traveller with fever.

  European journal of clinical pharmacology 20100801

• Do 5-fluorouracil therapies alter CYP2C19 metaboliser status?

  Cancer chemotherapy and pharmacology 20100701

• Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir.

  AIDS (London, England) 20100515

• Letter to the editor of travel medicine and infectious disease.

  Travel medicine and infectious disease 20100501

• Quantitative structure-activity relationships for cycloguanil analogs as PfDHFR inhibitors using mathematical molecular descriptors.

  SAR and QSAR in environmental research 20100401

• Chronic malaria infections increase family inequalities and reduce parental fitness: experimental evidence from a wild bird population.

  Journal of evolutionary biology 20100301

• Alteration of pharmacokinetics of proguanil in healthy volunteers following concurrent administration of efavirenz.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100219

• Shape- and chemical feature-based 3D-pharmacophore model generation and virtual screening: identification of potential leads for P. falciparum DHFR enzyme inhibition.

  Chemical biology & drug design 20100101

• Duration of protection against clinical malaria provided by three regimens of intermittent preventive treatment in Tanzanian infants.

  PloS one 20100101

• Intermittent preventive treatment in infants for the prevention of malaria in rural Western kenya: a randomized, double-blind placebo-controlled trial.

  PloS one 20100101

• Alternatives for malaria prophylaxis during the first trimester of pregnancy: our personal view.

  Journal of travel medicine 20100101

• Assessment of adherence to atovaquone-proguanil prophylaxis in travelers.

  Journal of travel medicine 20100101

• Different mutation patterns of Plasmodium falciparum among patients in Jimma University Hospital, Ethiopia.

  Malaria journal 20100101

• Direct quantitative bioanalysis of drugs in dried blood spot samples using a thin-layer chromatography mass spectrometer interface.

  Analytical chemistry 20091215

• Chlorproguanil-dapsone-artesunate versus chlorproguanil-dapsone: a randomized, double-blind, phase III trial in African children, adolescents, and adults with uncomplicated Plasmodium falciparum malaria.

  The American journal of tropical medicine and hygiene 20091201

• 3D-QSAR analysis of cycloguanil derivatives as inhibitors of A16V + S108T mutant Plasmodium falciparum dihydrofolate reductase enzyme.

  Journal of molecular graphics & modelling 20091101

• Effectiveness of malaria chemoprophylaxis against Plasmodium falciparum infection in UK travellers: retrospective observational data.

  Travel medicine and infectious disease 20091101

• Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.

  Lancet (London, England) 20091031

• Mefloquine has more adverse effects than other drugs for malaria prophylaxis.

  BMJ (Clinical research ed.) 20091013

• Drugs for preventing malaria in travellers.

  The Cochrane database of systematic reviews 20091007

• Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria.

  European journal of clinical pharmacology 20091001

• Plasmodium relictum (lineage P-SGS1): Further observation of effects on experimentally infected passeriform birds, with remarks on treatment with Malarone.

  Experimental parasitology 20091001

• Use of peroxisome proliferator-activated receptor gamma agonists as adjunctive treatment for Plasmodium falciparum malaria: a randomized, double-blind, placebo-controlled trial.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090915

• Drug impurity profiling by capillary electrophoresis/mass spectrometry using various ionization techniques.

  Rapid communications in mass spectrometry : RCM 20090901

• Effects of genetic variation at the CYP2C19/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians.

  Pharmacogenomics 20090901

• Structure-activity relationship and comparative docking studies for cycloguanil analogs as PfDHFR-TS inhibitors.

  Journal of chemical information and modeling 20090701

• Atovaquone + proguanil: new indication. For children weighing as little as 5 kg; an inconvenient form. A flavoured syrup would be better suited to infants and young children.

  Prescrire international 20090601

• Interactions between cycloguanil derivatives and wild type and resistance-associated mutant Plasmodium falciparum dihydrofolate reductases.

  Journal of computer-aided molecular design 20090401

• A novel in silico approach to drug discovery via computational intelligence.

  Journal of chemical information and modeling 20090401

• [Fever in returning travellers].

  Praxis 20090318

• Short report: comparison of chlorproguanil-dapsone with a combination of sulfadoxine-pyrimethamine and chloroquine in children with malaria in northcentral Nigeria.

  The American journal of tropical medicine and hygiene 20090201

• Evaluation of mood profiles during malaria chemoprophylaxis: a randomized, double-blind, four-arm study.

  Journal of travel medicine 20090101

• Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania.

  PloS one 20090101

• Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria.

  PloS one 20090101

• Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi.

  Malaria journal 20090101

• Influence of the genetic polymorphisms in the 5' flanking and exonic regions of CYP2C19 on proguanil oxidation.

  Drug metabolism and pharmacokinetics 20090101

• Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agents.

  Bioorganic & medicinal chemistry letters 20081215

• Bone marrow aplasia following acute poisoning with chloroquine-proguanil.

  Clinical toxicology (Philadelphia, Pa.) 20081201

• Well-tolerated chemoprophylaxis uniformly prevented Swedish soldiers from Plasmodium falciparum malaria in Liberia, 2004-2006.

  Military medicine 20081201

• Bullous erythema multiforme after treatment with Malarone, a combination antimalarial composed of atovaquone and proguanil hydrochloride.

  Tropical doctor 20080701

• Atovaquone-proguanil resistance in imported falciparum malaria in a young child.

  The Pediatric infectious disease journal 20080601

• Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer.

  Parasitology research 20080501

• A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20080501

• Failure of atovaquone/proguanil to prevent Plasmodium ovale malaria in traveler returning from Cameroon.

  Travel medicine and infectious disease 20080501

• Artemether + lumefantrine: new drug. An alternative to atovaquone + proguanil.

  Prescrire international 20080401

• A randomized clinical trial comparing safety, clinical and parasitological response to artemether-lumefantrine and chlorproguanil-dapsone in treatment of uncomplicated malaria in pregnancy in Mulago hospital, Uganda.

  Journal of infection in developing countries 20080401

• [Tolerance and efficacy of atovaquone-proguanil for the treatment of paediatric imported Plasmodium falciparum malaria in France: clinical practice in a university hospital in Paris].

  Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20080301

• Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines.

  Drug metabolism and disposition: the biological fate of chemicals 20080201

• Plasmodium falciparum malaria and atovaquone-proguanil treatment failure.

  Emerging infectious diseases 20080201

• An investigation into the native-like properties of de novo designed cavitand-based four-helix bundle proteins.

  Biopolymers 20080101

• In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand.

  Malaria journal 20080101

• Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falciparum malaria.

  PloS one 20080101

• Escalating Plasmodium falciparum antifolate drug resistance mutations in Macha, rural Zambia.

  Malaria journal 20080101

• An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria.

  PloS one 20080101

• Ototoxicity of artemether/lumefantrine in the treatment of falciparum malaria: a randomized trial.

  Malaria journal 20080101

• Trends in antimalarial prescriptions in Australia 2002 to 2005.

  Journal of travel medicine 20080101

• Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil.

  Malaria journal 20080101

• Pharmacodynamic interaction between monodesbutyl-benflumetol and artemisinin as well as proguanil in Plasmodium falciparum in vitro.

  Wiener klinische Wochenschrift 20080101

• High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency.

  PloS one 20080101

• Treatment of refractory Babesia microti infection with atovaquone-proguanil in an HIV-infected patient: case report.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071215

• The risk of antimalarials in patients with renal failure.

  Postgraduate medical journal 20071201

• Inadequate chemoprophylaxis and the risk of malaria.

  Australian family physician 20071201

• Malaria chemoprophylaxis: what do the travelers choose, and how does pretravel consultation influence their final decision.

  The American journal of tropical medicine and hygiene 20071201

• Selective ambulatory management of Plasmodium falciparum malaria in paediatric refugees.

  Archives of disease in childhood 20071101

• A systematic review and meta-analysis of the effectiveness and safety of atovaquone proguanil (Malarone) for chemoprophylaxis against malaria.

  The Journal of antimicrobial chemotherapy 20071101

• Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance.

  Clinical pharmacology and therapeutics 20071101

• Clinical efficacy of antiparasite treatments against intestinal helminths and haematic protozoa in Gallotia caesaris (lizards).

  Experimental parasitology 20070801

• Parallel evolution of adaptive mutations in Plasmodium falciparum mitochondrial DNA during atovaquone-proguanil treatment.

  Molecular biology and evolution 20070801

• The role of tryptophan-48 in catalysis and binding of inhibitors of Plasmodium falciparum dihydrofolate reductase.

  International journal for parasitology 20070601

• Chloroquine-resistant Plasmodium falciparum infections among UK travellers returning with malaria after chloroquine prophylaxis.

  The Journal of antimicrobial chemotherapy 20070601

• Sulfadoxine-pyrimethamine, chlorproguanil-dapsone, or chloroquine for the treatment of Plasmodium vivax malaria in Afghanistan and Pakistan: a randomized controlled trial.

  JAMA 20070523

• Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers.

  Basic & clinical pharmacology & toxicology 20070401

• Quality evaluation of chloroquine, quinine, sulfadoxine-pyrimethamine and proguanil formulations sold on the market in East Congo DR.

  Journal of clinical pharmacy and therapeutics 20070401

• Efficacy of atovaquone-proguanil for treatment of acute multidrug-resistant Plasmodium falciparum malaria in Thailand.

  The American journal of tropical medicine and hygiene 20070401

• Cerebral malaria in spite of peripheral parasite clearance in a patient treated with atovaquone/proguanil.

  Parasitology research 20070301

• Analyses of cytochrome b mutations in Plasmodium falciparum isolates in Thai-Myanmar border.

  Travel medicine and infectious disease 20070301

• Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum.

  Nature 20070301

• Simultaneous determination of monodesethylchloroquine, chloroquine, cycloguanil and proguanil on dried blood spots by reverse-phase liquid chromatography.

  Journal of pharmaceutical and biomedical analysis 20070219

• Atovaquone-proguanil: report from the CDC expert meeting on malaria chemoprophylaxis (II).

  The American journal of tropical medicine and hygiene 20070201

• The safety and tolerance of atovaquone/proguanil for the long-term prophylaxis of plasmodium falciparum malaria in non-immune travelers and expatriates [corrected].

  Journal of travel medicine 20070101

• Hodgkin lymphoma in a child with sickle cell anemia.

  Pediatric hematology and oncology 20070101

• A man with tropical travel history, fever, and pulmonary infiltrates.

  Comprehensive therapy 20070101

• Relapsing vivax malaria after 6 months of daily atovaquone/proguanil in Afghanistan: the case for expanded use of primaquine as a causal prophylactic.

  Journal of travel medicine 20070101

• Outpatient treatment of malaria in recently arrived African migrants.

  The Medical journal of Australia 20061201

• A randomised, double-blind, placebo-controlled trial of atovaquone-proguanil vs. sulphadoxine-pyrimethamine in the treatment of malarial anaemia in Zambian children.

  Tropical medicine & international health : TM & IH 20061101

• Plasmodium falciparum malaria associated with mefloquine failure in Gambia.

  Pharmacotherapy 20061001

• Amino acid mutations in Plasmodium vivax DHFR and DHPS from several geographical regions and susceptibility to antifolate drugs.

  The American journal of tropical medicine and hygiene 20061001

• Efficacy and safety of atovaquone-proguanil compared with mefloquine in the treatment of nonimmune patients with uncomplicated P. falciparum malaria in Japan.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20061001

• Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations.

  Microbes and infection 20060901

• Randomized, double-blind, placebo-controlled study of Malarone for malaria prophylaxis in non-immune Colombian soldiers.

  The American journal of tropical medicine and hygiene 20060901

• Evaluation of the bio-efficacy of three brands of repellents against wild populations of anthropophilic mosquitoes.

  Tanzania health research bulletin 20060901

• Resisting resistance: dealing with the irrepressible problem of malaria.

  British journal of clinical pharmacology 20060601

• Folic acid treatment of Zambian children with moderate to severe malaria anemia.

  The American journal of tropical medicine and hygiene 20060601

• Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria.

  European journal of clinical pharmacology 20060501

• Efficacy of chloroquine-proguanil malaria prophylaxis in a non-immune population in Bangui, Central African Republic: a case-control study.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20060401

• [Malaria: a medical and economic problem].

  Presse medicale (Paris, France : 1983) 20060401

• [Retrospective analysis of 107 imported adult cases of malaria. Experience report of uncomplicated falciparum malaria treatment in adults with oral atovaquone-proguanil].

  Presse medicale (Paris, France : 1983) 20060401

• Multiple synergistic interactions between atovaquone and antifolates against Plasmodium falciparum in vitro: a rational basis for combination therapy.

  Acta tropica 20060301

• Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone.

  British journal of clinical pharmacology 20060301

• Sensitive method for the quantitative determination of proguanil and its metabolites in rat blood and plasma by liquid chromatography-mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060118

• Apparent absence of atovaquone/proguanil resistance in 477 Plasmodium falciparum isolates from untreated French travellers.

  The Journal of antimicrobial chemotherapy 20060101

• [Cytochrome P-450 and the response to antimalarial drugs].

  Revista panamericana de salud publica = Pan American journal of public health 20060101

• Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola.

  Malaria journal 20060101

• Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa.

  Malaria journal 20060101

• [Severe imported malaria. The experience of the military hospital of Marrakech].

  Annales de biologie clinique 20060101

• Tertian malaria (Plasmodium vivax and Plasmodium ovale) in two travelers despite atovaquone-proguanil prophylaxis.

  Journal of travel medicine 20060101

• Molecular surveillance of mutations in the cytochrome b gene of Plasmodium falciparum in Gabon and Ethiopia.

  Malaria journal 20060101

• Pharmacodynamic interaction between atovaquone and other antimalarial compounds against Plasmodium falciparum in vitro.

  Wiener klinische Wochenschrift 20060101

• [Severe imported malaria: the experience of the Avicenna military hospital of Marrakech].

  Sante (Montrouge, France) 20060101

• Atovaquone/proguanil for the prophylaxis and treatment of malaria.

  Expert review of anti-infective therapy 20051201

• Malaria: prevention in travellers.

  Clinical evidence 20051201

• Plasmodium falciparum: interaction of shikimate analogues with antimalarial drugs.

  Experimental parasitology 20051101

• [Ineffective change of antimalaria prophylaxis to Artemisia vulgaris in a group travelling to West Africa].

  Ugeskrift for laeger 20051024

• Atovaquone-proguanil for treating uncomplicated malaria.

  The Cochrane database of systematic reviews 20051019

• [Malaria chemoprophylaxis].

  Ugeskrift for laeger 20051017

• [Malaria prophylaxis for long-term travellers and expatriates].

  Ugeskrift for laeger 20051017

• A simple dual selection for functionally active mutants of Plasmodium falciparum dihydrofolate reductase with improved solubility.

  Protein engineering, design & selection : PEDS 20051001

• Susceptibility studies of Malaysian Plasmodium falciparum clones to type II antifolate drugs after 3 years of continuous in vitro culture.

  Chemotherapy 20051001

• The pharmacokinetics and pharmacodynamics of atovaquone and proguanil for the treatment of uncomplicated falciparum malaria in third-trimester pregnant women.

  European journal of clinical pharmacology 20050901

• A randomized comparison of artesunate-atovaquone-proguanil versus quinine in treatment for uncomplicated falciparum malaria during pregnancy.

  The Journal of infectious diseases 20050901

• Consumption of charcoal-broiled meat as an experimental tool for discerning CYP1A2-mediated drug metabolism in vivo.

  Basic & clinical pharmacology & toxicology 20050901

• Hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil.

  International journal of antimicrobial agents 20050801

• Short report: no evidence of cardiotoxicity of atovaquone-proguanil alone or in combination with artesunate.

  The American journal of tropical medicine and hygiene 20050801

• Effectiveness of antimalarial drugs.

  The New England journal of medicine 20050728

• Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni.

  Molecular and biochemical parasitology 20050701

• The chemotherapy of rodent malaria. LXIII. Drug combinations to impede the selection of drug resistance, part 6: the potential value of chlorproguanil and dapsone in combination, and with the addition of artesunate.

  Annals of tropical medicine and parasitology 20050701

• Occult Plasmodium vivax infection diagnosed by a polymerase chain reaction-based detection system: a case report.

  The American journal of tropical medicine and hygiene 20050701

• Prediction of genotoxicity of chemical compounds by statistical learning methods.

  Chemical research in toxicology 20050601

• Malaria: uncomplicated, caused by Plasmodium falciparum.

  Clinical evidence 20050601

• In vitro metabolism of phenoxypropoxybiguanide analogues in human liver microsomes to potent antimalarial dihydrotriazines.

  Journal of medicinal chemistry 20050421

• Emergence of atovaquone-proguanil resistance during treatment of Plasmodium falciparum malaria acquired by a non-immune north American traveller to west Africa.

  The American journal of tropical medicine and hygiene 20050401

• [Color reaction of chlorhexidine and proguanil with hypobromite].

  Die Pharmazie 20050401

• Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase.

  Analytical chemistry 20050301

• A randomized open label clinical trial to compare the efficacy and safety of intravenous quinine followed by oral malarone vs. intravenous quinine followed by oral quinine in the treatment of severe malaria.

  Journal of tropical pediatrics 20050201

• Efficacy of antimalarial chemoprophylaxis among French residents travelling to Africa.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20050201

• Artesunate-dapsone-proguanil treatment of falciparum malaria: genotypic determinants of therapeutic response.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20050201

• Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents.

  Bioorganic & medicinal chemistry letters 20050201

• A malaria outbreak following a British military deployment to Sierra Leone.

  The Journal of infection 20050201

• In vitro recrudescence of Plasmodium falciparum parasites suppressed to dormant state by atovaquone alone and in combination with proguanil.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20050101

• Novel alleles of Plasmodium falciparum dhfr that confer resistance to chlorcycloguanil.

  Molecular and biochemical parasitology 20050101

• Simultaneous quantitation of the highly lipophilic atovaquone and hydrophilic strong basic proguanil and its metabolites using a new mixed-mode SPE approach and steep-gradient LC.

  Journal of chromatographic science 20050101

• Malaria prophylaxis for aircrew: safety of atovaquone/proguanil in healthy volunteers under aircraft cabin pressure conditions.

  Journal of travel medicine 20050101

• Acute hepatitis and atovaquone/proguanil.

  Journal of travel medicine 20050101

• Pfcrt K76T mutation and its associations in imported Plasmodium falciparum malaria cases.

  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20041201

• Developmental toxicity of artesunate and an artesunate combination in the rat and rabbit.

  Birth defects research. Part B, Developmental and reproductive toxicology 20041201

• The chemotherapy of rodent malaria. LXII. Drug combinations to impede the selection of drug resistance, part 5: rates of development of resistance to some inhibitors of folate metabolism and to artesunate.

  Annals of tropical medicine and parasitology 20041201

• Rare, highly pyrimethamine-resistant alleles of the Plasmodium falciparum dihydrofolate reductase gene from 5 African sites.

  The Journal of infectious diseases 20041115

• Screening for mutations related to atovaquone/proguanil resistance in treatment failures and other imported isolates of Plasmodium falciparum in Europe.

  The Journal of infectious diseases 20041101

• Chlorproguanil-dapsone for malaria.

  Lancet (London, England) 20041101

• Chlorproguanil-dapsone for treating uncomplicated malaria.

  The Cochrane database of systematic reviews 20041018

• Quinine-resistant severe falciparum malaria effectively treated with atovaquone and proguanil hydrochloride combination therapy.

  Internal medicine (Tokyo, Japan) 20040701

• [Malaria: prophylaxis, treatment, stand-by medication. A single mosquito bite suffices].

  MMW Fortschritte der Medizin 20040617

• Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in nonimmune pediatric travelers: results of an international, randomized, open-label study.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040615

• Chlorproguanil-dapsone for malaria in Africa.

  Lancet (London, England) 20040605

• Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial.

  Lancet (London, England) 20040605

• Malaria: prevention in travellers.

  Clinical evidence 20040601

• Short communication: Prevalence of mutations associated with resistance to atovaquone and to the antifolate effect of proguanil in Plasmodium falciparum isolates from northern Ghana.

  Tropical medicine & international health : TM & IH 20040301

• A malaria outbreak following a British military deployment to Sierra Leone.

  The Journal of infection 20040201

• CV8, a new combination of dihydroartemisinin, piperaquine, trimethoprim and primaquine, compared with atovaquone-proguanil against falciparum malaria in Vietnam.

  Tropical medicine & international health : TM & IH 20040201

• Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.

  Journal of medicinal chemistry 20040129

• Susceptibility of Plasmodium falciparum to the drugs used to treat severe malaria (quinine) and to prevent malaria (mefloquine, cycloguanil) in Comoros Union and Madagascar.

  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20040101

• [Pharmaceutical care for international voyagers: prophylaxis including chloroquine plus proguanil].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20040101

• Malarone treatment failure not associated with previously described mutations in the cytochrome b gene.

  Malaria journal 20040101

• Atovaquone-proguanil (malarone): an effective treatment for uncomplicated Plasmodium falciparum malaria in travelers from Denmark.

  Journal of travel medicine 20040101

• Long-term malaria prophylaxis for travelers.

  Journal of travel medicine 20040101

• Atovaquone and proguanil versus amodiaquine for the treatment of Plasmodium falciparum malaria in African infants and young children.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031201

• Military aviators, special operations forces, and causal malaria prophylaxis.

  Military medicine 20031201

• Malaria: prevention in travellers.

  Clinical evidence 20031201

• Diagnosis and treatment of malaria in children.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031115

• New antimalarial drugs.

  Angewandte Chemie (International ed. in English) 20031110

• Concordance between proguanil phenotype and CYP2C19 genotype in Chinese.

  European journal of clinical pharmacology 20031101

• Analysis of Sepik populations of Papua New Guinea suggests an increase of CYP2C19 null allele frequencies during the colonization of Melanesia.

  Pharmacogenetics 20031101

• Pregnancy and use of oral contraceptives reduces the biotransformation of proguanil to cycloguanil.

  European journal of clinical pharmacology 20031001

• The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria.

  European journal of clinical pharmacology 20031001

• [Oxcarbazepine-induced encephalopathy].

  Presse medicale (Paris, France : 1983) 20030906

• Atovaquone-proguanil for prophylaxis and treatment of malaria.

  The Annals of pharmacotherapy 20030901

• New malaria drug to be unveiled in Africa.

  Nature medicine 20030901

• Atovaquone-proguanil for recrudescent Plasmodium falciparum in Vietnam.

  Annals of tropical medicine and parasitology 20030901

• Malaria and children: the risks, precautions, and the nurse's role.

  Professional nurse (London, England) 20030901

• Roll back of Plasmodium falciparum antifolate resistance by insecticide-treated nets.

  The American journal of tropical medicine and hygiene 20030901

• Drug company to offer new malaria drug cheaply in Africa.

  BMJ (Clinical research ed.) 20030816

• Antidiabetic and antimalarial biguanide drugs are metal-interactive antiproteolytic agents.

  Biochemical pharmacology 20030815

• Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030801

• DHFR and DHPS genotypes of Plasmodium falciparum isolates from Gabon correlate with in vitro activity of pyrimethamine and cycloguanil, but not with sulfadoxine-pyrimethamine treatment efficacy.

  The Journal of antimicrobial chemotherapy 20030701

• Stevens-Johnson syndrome associated with Malarone antimalarial prophylaxis.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030701

• The impact of Malarone and primaquine on psychomotor performance.

  Aviation, space, and environmental medicine 20030701

• [Malaria--case report].

  Deutsche medizinische Wochenschrift (1946) 20030606

• Atovaquone/proguanil: the need for family protection.

  Journal of travel medicine 20030501

• The safety of atovaquone/proguanil in long-term malaria prophylaxis of nonimmune adults.

  Journal of travel medicine 20030501

• Post-marketing surveillance: adverse events during long-term use of atovaquone/proguanil for travelers to malaria-endemic countries.

  Journal of travel medicine 20030501

• Toxicity related to chloroquine treatment of resistant vivax malaria.

  The Annals of pharmacotherapy 20030401

• The mechanisms of resistance to antimalarial drugs in Plasmodium falciparum.

  Fundamental & clinical pharmacology 20030401

• The new drug combinations: their place in the treatment of uncomplicated Plasmodium falciparum malaria.

  Fundamental & clinical pharmacology 20030401

• Problems in prescribing malaria chemoprophylaxis for travelers.

  Fundamental & clinical pharmacology 20030401

• Parasitemia in children with Plasmodium falciparum malaria receiving chemoprophylaxis.

  The Pediatric infectious disease journal 20030401

• Malaria in Austria 1990-2000.

  Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20030401

• Evidence of Plasmodium falciparum malaria resistant to atovaquone and proguanil hydrochloride: case reports.

  BMJ (Clinical research ed.) 20030322

• The development of Lapdap, an affordable new treatment for malaria.

  The Lancet. Infectious diseases 20030301

• Malaria: use of restriction endonuclease digestion and mutation-specific PCR for antifolate resistance isolate detection.

  Parassitologia 20030301

• [Three newly registered drugs in the Netherlands for the treatment and chemoprophylaxis of malaria: atovaquone-proguanil, artemether-lumefantrine and artemotil].

  Nederlands tijdschrift voor geneeskunde 20030215

• Utilisation of malaria prophylaxis: the effect of changes in guidelines in The Netherlands, 1993-1998.

  Pharmacy world & science : PWS 20030201

• [Adverse drug reactions (ADRs) to antimalarial drugs. Analysis of spontaneous report from the French pharmacovigilance database (1996-2000)].

  Presse medicale (Paris, France : 1983) 20030125

• Synthesis of solution-phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum.

  Bioorganic & medicinal chemistry 20030117

• Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.

  Archives of biochemistry and biophysics 20030101

• Persistence of atovaquone in human sera following treatment: inhibition of Plasmodium falciparum development in vivo and in vitro.

  The American journal of tropical medicine and hygiene 20030101

• Atovaquone/proguanil: a review of its use for the prophylaxis of Plasmodium falciparum malaria.

  Drugs 20030101

• Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo: rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker.

  Malaria journal 20030101

• Severe mucocutaneous necrotizing vasculitis associated with the combination of chloroquine and proguanil.

  Acta dermato-venereologica 20030101

• The efficacy of chemoprophylaxis against malaria with chloroquine plus proguanil, mefloquine, and atovaquone plus proguanil in travelers from Denmark.

  Journal of travel medicine 20030101

• Trends in antimalarial drugs prescribed in Australia 1992 to 1998.

  Journal of travel medicine 20030101

• Trends in antimalarial drugs prescribed in New Zealand 1993 to 1998.

  Journal of travel medicine 20030101

• Current status and replies to frequently posed questions on atovaquone plus proguanil (Malarone) for the prevention of malaria.

  BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20030101

• Detection of atovaquone and Malarone resistance conferring mutations in Plasmodium falciparum cytochrome b gene (cytb).

  Molecular and cellular probes 20030101

• Plasmodium falciparum outwits Malarone, protector of travellers.

  Bulletin of the World Health Organization 20030101

• Variation of malaria transmission and morbidity with altitude in Tanzania and with introduction of alphacypermethrin treated nets.

  Malaria journal 20030101

• Antimosquito precautions and medical chemoprophylaxis in French children with malaria.

  Journal of travel medicine 20030101

• Plasmodium vivax malaria in spite of atovaquone/proguanil (malarone) prophylaxis.

  Journal of travel medicine 20030101

• Atovaquone/proguanil resistance in Africa: a case report.

  Scandinavian journal of infectious diseases 20030101

• Malaria prophylaxis in post renal transplant recipients in the tropics: is it necessary?

  The Central African journal of medicine 20030101

• Pharmacodynamic interactions among atovaquone, proguanil and cycloguanil against Plasmodium falciparum in vitro.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20030101

• Artesunate-atovaquone-proguanil rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20030101

• [Presence of pyrimethamine and cycloguanil resistance genotype in West Africa? Evidence of a single mutation 59Arg in the dhfr gene of Plasmodium falciparum].

  Acta medica portuguesa 20030101

• Mutations in dhfr in Plasmodium falciparum infections selected by chlorproguanil-dapsone treatment.

  The Journal of infectious diseases 20021215

• Treatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021215

• Effect of proguanil interaction on bioavailability of cloxacillin.

  Journal of clinical pharmacy and therapeutics 20021201

• In vitro sensitivity of Plasmodium falciparum to amodiaquine compared with other major antimalarials in Madagascar.

  Parassitologia 20021201

• Proguanil plus sulfamethoxazole in the treatment of uncomplicated Plasmodium falciparum malaria.

  The Southeast Asian journal of tropical medicine and public health 20021201

• Efficacy of atovaquone/proguanil for malaria prophylaxis in children and its effect on the immunogenicity of live oral typhoid and cholera vaccines.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021115

• Atovaquone/proguanil therapy for Plasmodium falciparum and Plasmodium vivax malaria in Indonesians who lack clinical immunity.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021101

• Tolerability of doxycycline monohydrate salt vs. chloroquine-proguanil in malaria chemoprophylaxis.

  Tropical medicine & international health : TM & IH 20021101

• Polymorphic oxidative metabolism of proguanil in a Nigerian population.

  European journal of clinical pharmacology 20021101

• Massive hepatosplenomegaly in a child with malaria.

  The Pediatric infectious disease journal 20021101

• Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial.

  Lancet (London, England) 20021012

• Randomized, placebo-controlled trial of atovaquone/proguanil for the prevention of Plasmodium falciparum or Plasmodium vivax malaria among migrants to Papua, Indonesia.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021001

• Atovaquone + proguanil: new preparation. Second-line antimalarial combination.

  Prescrire international 20021001

• Molecular epidemiology of malaria in Cameroon. XII. In vitro drug assays and molecular surveillance of chloroquine and proguanil resistance.

  The American journal of tropical medicine and hygiene 20021001

• [Preventive vaccination for travel. Every dog has it, but only every 10th grandmother].

  MMW Fortschritte der Medizin 20020919

• [Blackwater fever].

  Presse medicale (Paris, France : 1983) 20020907

• Atovaquone plus chloroguanide versus mefloquine for malaria prophylaxis: a focus on neuropsychiatric adverse events.

  Clinical pharmacology and therapeutics 20020901

• [Value of malarone in therapy of malaria tropica].

  Medizinische Klinik (Munich, Germany : 1983) 20020815

• Molecular modeling of wild-type and antifolate resistant mutant Plasmodium falciparum DHFR.

  Biophysical chemistry 20020802

• Atovaquone/proguanil for plasmodium falciparum malaria.

  The Pediatric infectious disease journal 20020801

• [New strategies in therapy to roll back malaria].

  Deutsche medizinische Wochenschrift (1946) 20020726

• Profile and evolution of the chemosusceptibility of falciparum malaria imported into France in 2000.

  Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20020701

• [Many travellers suffer of side-effects of malaria prophylaxis].

  Lakartidningen 20020627

• [A collective malarial infestation during a humanitarian mission in west Africa].

  Bulletin de la Societe de pathologie exotique (1990) 20020601

• Tolerability of antimalaria drugs.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020501

• Polyclonal Plasmodium falciparum malaria in travelers and selection of antifolate mutations after proguanil prophylaxis.

  The American journal of tropical medicine and hygiene 20020501

• Time-dependent pharmacokinetics and drug metabolism of atovaquone plus proguanil (Malarone) when taken as chemoprophylaxis.

  European journal of clinical pharmacology 20020401

• Lariam's legacy.

  Consumer reports 20020301

• Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria.

  The Journal of infectious diseases 20020201

• Dual-mode gradient HPLC procedure for the simultaneous determination of chloroquine and proguanil.

  Journal of pharmaceutical and biomedical analysis 20020101

• Malaria deaths following inappropriate malaria chemoprophylaxis--United States, 2001.

  Annals of emergency medicine 20020101

• [Malarone: a new antimalarial for malaria chemoprevention].

  Medecine tropicale : revue du Corps de sante colonial 20020101

• Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria.

  Malaria journal 20020101

• Bioequivalence evaluation of a fixed combination of chloroquine and proguanil in a capsule formulation versus a standard medication.

  Arzneimittel-Forschung 20020101

• Trends in antimalarial drugs prescribed in New Zealand 1993 to 1998.

  Journal of travel medicine 20020101

• [Mechanism of action of antimalarials. Value of combined atovaquone/proguanil].

  Medecine tropicale : revue du Corps de sante colonial 20020101

• [Clinical studies using the combination atovaquone-proguanil as malaria prophylaxis in non-immune adult and child travelers].

  Medecine tropicale : revue du Corps de sante colonial 20020101

• [Experience with the combination atovaquone-proguanil in the treatment of uncomplicated Plasmodium falciparum malaria--report of 112 cases].

  Medecine tropicale : revue du Corps de sante colonial 20020101

• [What is the value of the combination atovaquone-proguanil for the clinician?].

  Medecine tropicale : revue du Corps de sante colonial 20020101

• A public-private partnership for malaria control: lessons from the Malarone Donation Programme.

  Bulletin of the World Health Organization 20020101

• Trends in malaria chemoprophylaxis prescription in South Africa 1994 to 2000.

  Journal of travel medicine 20020101

• Randomized, parallel placebo-controlled trial of primaquine for malaria prophylaxis in Papua, Indonesia.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20011215

• Plasmodium falciparum: pfcrt and DHFR mutations are associated with failure of chloroquine plus proguanil prophylaxis in travelers.

  The Journal of infectious diseases 20011215

• Current drugs for antimalarial chemoprophylaxis: a review of efficacy and safety.

  Journal of travel medicine 20011201

• [Epileptic crisis after antimalaria chemoprophylaxis with chloroquine].

  Presse medicale (Paris, France : 1983) 20011124

• Phenoxypropoxybiguanides, prodrugs of DHFR-inhibiting diaminotriazine antimalarials.

  Journal of medicinal chemistry 20011108

• Subacute malaria due to Plasmodium falciparum and the role of polymerase chain reaction.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20011101

• Chlorproguanil-dapsone (LAPDAP) for uncomplicated falciparum malaria.

  Tropical medicine & international health : TM & IH 20011101

• Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania.

  Lancet (London, England) 20011013

• Atovaquone-proguanil versus mefloquine for malaria prophylaxis in nonimmune travelers: results from a randomized, double-blind study.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20011001

• What's new: newly approved drugs for children.

  Pediatrics in review 20011001

• [symbol: see text] Atovaquone + proguanil for malaria prophylaxis.

  Drug and therapeutics bulletin 20011001

• Malaria remains a military medical problem.

  Journal of the Royal Army Medical Corps 20011001

• Novel alleles of the Plasmodium falciparum dhfr highly resistant to pyrimethamine and chlorcycloguanil, but not WR99210.

  Molecular and biochemical parasitology 20010928

• Death from malaria following inappropriate chemoprophylaxis.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010901

• From the Centers for Disease Control and Prevention. Malaria deaths following inappropriate malaria chemoprophylaxis--United States, 2001.

  JAMA 20010815

• Homology modeling of wild type and pyrimethamine/cycloguanil-cross resistant mutant type Plasmodium falciparum dihydrofolate reductase. A model for antimalarial chemotherapy resistance.

  Biophysical chemistry 20010724

• Malaria deaths following inappropriate malaria chemoprophylaxis--United States, 2001.

  MMWR. Morbidity and mortality weekly report 20010720

• Malaria chemoprophylaxis in the age of drug resistance. I. Currently recommended drug regimens.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010715

• [Expanded arsenal for prevention and therapy. What is the value of the new malaria drugs? (interview by Waltraut Paukstadt)].

  MMW Fortschritte der Medizin 20010705

• Subacute clinical forms of Plasmodium falciparum malaria in travelers receiving chloroquine-proguanil prophylaxis.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010701

• A political analysis of corporate drug donations: the example of Malarone in Kenya.

  Health policy and planning 20010601

• Microbial drug resistance and the roles of the new antibiotics.

  Cleveland Clinic journal of medicine 20010601

• [Malaria--chemoprophylaxis 2001].

  Therapeutische Umschau. Revue therapeutique 20010601

• Analysis of proguanil and its metabolites by application of the sweeping technique in micellar electrokinetic chromatography.

  Journal of chromatography. A 20010504

• Efficacy of atovaquone-proguanil?

  Lancet (London, England) 20010421

• Genome comparison of progressively drug resistant Plasmodium falciparum lines derived from drug sensitive clone.

  Memorias do Instituto Oswaldo Cruz 20010401

• Atovaquone and proguani hydrochloride compared with chloroquine or pyrimethamine/sulfodaxine for treatment of acute Plasmodium falciparum malaria in Peru.

  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20010401

• Mode of action and mechanisms of resistance for antimalarial drugs.

  Pharmacology & therapeutics 20010201

• Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s.

  Drug metabolism and disposition: the biological fate of chemicals 20010101

• [Severe skin disease induced by a chloroquine-proguanil combination].

  Therapie 20010101

• Studies of the complexation of chloranilic acid with proguanil.

  Bollettino chimico farmaceutico 20010101

• Causal prophylactic efficacy of atovaquone-proguanil (Malarone) in a human challenge model.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20010101

• A trial of proguanil-dapsone in comparison with sulfadoxine-pyrimethamine for the clearance of Plasmodium falciparum infections in Tanzania.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20010101

• The Italian army standpoint on malaria chemoprophylaxis.

  Medecine tropicale : revue du Corps de sante colonial 20010101

• The malaria threat.

  Medecine tropicale : revue du Corps de sante colonial 20010101

• [Gene point mutation in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20010101

• Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in non-immune travellers: a randomised, double-blind study. Malarone International Study Team.

  Lancet (London, England) 20001202

• Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum.

  The Journal of infectious diseases 20000601

• Seizures after antimalarial medication in previously healthy persons.

  Journal of travel medicine 20000101

• A mechanism for the synergistic antimalarial action of atovaquone and proguanil.

  Antimicrobial agents and chemotherapy 19990601

• The antimalarial triazine WR99210 and the prodrug PS-15: folate reversal of in vitro activity against Plasmodium falciparum and a non-antifolate mode of action of the prodrug.

  The American journal of tropical medicine and hygiene 19990601

• Neuro-psychiatric effects of antimalarials.

  European journal of clinical pharmacology 19970101

• Adverse effects and compliance with mefloquine or proguanil antimalarial chemoprophylaxis.

  European journal of clinical pharmacology 19970101

• Adverse events associated with mefloquine. Study in returned travellers confirms authors' findings.

  BMJ (Clinical research ed.) 19961214

• Combination of PS-15, epiroprim, or pyrimethamine with dapsone in prophylaxis of Toxoplasma gondii and Pneumocystis carinii dual infection in a rat model.

  Antimicrobial agents and chemotherapy 19960901

• Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: postal and telephone survey of travellers.

  BMJ (Clinical research ed.) 19960831

• In vitro activities of PS-15, a new dihydrofolate reductase inhibitor, and its cyclic metabolite against Mycobacterium avium complex.

  Antimicrobial agents and chemotherapy 19950801

• Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro.

  Experimental parasitology 19950501

• Effect of atovaquone and atovaquone drug combinations on prophylaxis of Pneumocystis carinii pneumonia in SCID mice.

  Antimicrobial agents and chemotherapy 19950401

• Relative potency of 10 drugs with anti-Pneumocystis carinii activity in an animal model.

  The Journal of infectious diseases 19941001

• In vitro effects of artemisinin ether, cycloguanil hydrochloride (alone and in combination with sulfadiazine), quinine sulfate, mefloquine, primaquine phosphate, trifluoperazine hydrochloride, and verapamil on Toxoplasma gondii.

  Antimicrobial agents and chemotherapy 19940601

• Anti-Pneumocystis carinii activity of PS-15, a new biguanide folate antagonist.

  Antimicrobial agents and chemotherapy 19930701

• Mefloquine.

  Lancet (London, England) 19930619

• Chloroquine-induced mania.

  The British journal of psychiatry : the journal of mental science 19910701

• In vitro cultivation of Cryptosporidium parvum and screening for anticryptosporidial drugs.

  Antimicrobial agents and chemotherapy 19900801

• Neuromyopathy associated with amodiaquine hydrochloride.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 19871001

• A case of recurrent subacute disseminated intravascular coagulation associated with malarial prophylaxis.

  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 19750125