50675-18-8 | 4-Formyltetrahydropyran

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$8.00	$6.00
1g	97%	in stock	$10.00	$7.00

Description

• Catalog Number: AB49845
• Chemical Name: 4-Formyltetrahydropyran
• CAS Number: 50675-18-8
• Molecular Formula: C6H10O2
• Molecular Weight: 114.1424
• MDL Number: MFCD03425264
• SMILES: O=CC1CCOCC1

Computed Properties

• Complexity: 74.6
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 8
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1

Upstream Synthesis Route

To synthesize 4-Formyltetrahydropyran, the starting material is often dihydropyran. The chemical synthesis proceeds via the following steps:

1. **Oxidation of Dihydropyran:** Dihydropyran can be oxidized using an appropriate oxidizing agent such as chromium(VI) oxide (CrO₃) to form tetrahydropyran-4-carboxylic acid.

2. **Decarboxylation:** The tetrahydropyran-4-carboxylic acid can then be decarboxylated typically by heating, to give 4-formyltetrahydropyran.

Alternatively:

1. **Hydroformylation of 4-Pentenal:** Begin with 4-pentenal, which can undergo hydroformylation in the presence of a rhodium catalyst and carbon monoxide and hydrogen gases to afford 4-formyltetrahydropyran directly.

The conditions for these reactions, such as temperature, pressure, and time, are to be optimized based on the desired scale of synthesis and the available apparatus. The purity of the product can be verified by standard analytical techniques like NMR, and the reaction can be followed up using TLC.

Literature

• Orally available Mn porphyrins with superoxide dismutase and catalase activities.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090801