50892-23-4 | [4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$16.00	$11.00
10mg	98%	in stock	$20.00	$14.00
50mg	98%	in stock	$39.00	$27.00
100mg	98%	in stock	$44.00	$31.00
250mg	98%	in stock	$69.00	$48.00
1g	98%	in stock	$154.00	$108.00
5g	98%	in stock	$462.00	$324.00

Description

• Catalog Number: AB80374
• Chemical Name: [4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid
• CAS Number: 50892-23-4
• Molecular Formula: C14H14ClN3O2S
• Molecular Weight: 323.7979
• MDL Number: MFCD00191335
• SMILES: OC(=O)CSc1nc(cc(n1)Cl)Nc1cccc(c1C)C
• NSC Number: 310038

Computed Properties

• Complexity: 361
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 5
• XLogP3: 4.2

Literature

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• Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.

  Journal of medicinal chemistry 20080911

• Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice.

  Journal of hepatology 20080901

• A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats.

  Toxicology 20080819

• Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.

  Diabetes 20080801

• Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists.

  Bioorganic & medicinal chemistry 20080801

• Characterization of Madin-Darby bovine kidney cell line for peroxisome proliferator-activated receptors: temporal response and sensitivity to fatty acids.

  Journal of dairy science 20080701

• The in vivo gene expression signature of oxidative stress.

  Physiological genomics 20080612

• Effect of peroxisome proliferator-activated receptor-alpha ligands in the interaction between adipocytes and macrophages in obese adipose tissue.

  Obesity (Silver Spring, Md.) 20080601

• Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha.

  Biochimica et biophysica acta 20080601

• Gene profiling in the livers of wild-type and PPARalpha-null mice exposed to perfluorooctanoic acid.

  Toxicologic pathology 20080601

• Comparative hepatic effects of perfluorooctanoic acid and WY 14,643 in PPAR-alpha knockout and wild-type mice.

  Toxicologic pathology 20080601

• 1Alpha,25-dihydroxyvitamin D3 attenuates cyanide-induced neurotoxicity by inhibiting uncoupling protein-2 up-regulation.

  Journal of neuroscience research 20080501

• Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR.

  Toxicological sciences : an official journal of the Society of Toxicology 20080501

• In vivo imaging reveals selective peroxisome proliferator activated receptor modulator activity of the synthetic ligand 3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid (MK-886).

  Molecular pharmacology 20080501

• Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers.

  European journal of pharmacology 20080428

• PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators.

  Toxicology 20080403

• Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis.

  The Journal of allergy and clinical immunology 20080401

• Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine.

  Biochimica et biophysica acta 20080401

• Nuclear receptor agonists improve insulin responsiveness in cultured cardiomyocytes through enhanced signaling and preserved cytoskeletal architecture.

  Endocrinology 20080301

• Modulation of receptor phosphorylation contributes to activation of peroxisome proliferator activated receptor alpha by dehydroepiandrosterone and other peroxisome proliferators.

  Molecular pharmacology 20080301

• Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.

  Bioorganic & medicinal chemistry 20080301

• Alpha-alkyl substituted pirinixic acid derivatives as potent dual agonists of the peroxisome proliferator activated receptor alpha and gamma.

  Archiv der Pharmazie 20080301

• Peroxisome proliferator-activated receptor alpha activation attenuated angiotensin type 1-mediated but enhanced angiotensin type 2-mediated hemodynamic effects to angiotensin II in the rat.

  Journal of hypertension 20080301

• Down-regulation of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase by polyunsaturated fatty acids in hepatocytes is not mediated by PPARalpha.

  European journal of nutrition 20080301

• The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha.

  Toxicological sciences : an official journal of the Society of Toxicology 20080101

• Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive oxygen species-dependent mechanism.

  Stem cells (Dayton, Ohio) 20080101

• Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies.

  Environmental health perspectives 20080101

• Placental implications of peroxisome proliferator-activated receptors in gestation and parturition.

  PPAR research 20080101

• Effect of synthetic dietary triglycerides: a novel research paradigm for nutrigenomics.

  PloS one 20080101

• PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression.

  BMC genomics 20080101

• Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response.

  BMC genomics 20080101

• Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders.

  PPAR research 20080101

• PPARalpha- and DEHP-Induced Cancers.

  PPAR research 20080101

• Analgesic properties of oleoylethanolamide (OEA) in visceral and inflammatory pain.

  Pain 20071215

• Time course investigation of PPARalpha- and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression.

  Toxicology and applied pharmacology 20071215

• Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver.

  The Journal of biological chemistry 20071214

• PPARalpha-dependent induction of the energy homeostasis-regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: potential role in starvation adaptation.

  FEBS letters 20071211

• Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha.

  Mutation research 20071201

• Inactivation of peroxisome proliferator-activated receptor isoforms alpha, beta/delta, and gamma mediate distinct facets of hypertrophic transformation of adult cardiac myocytes.

  Pflugers Archiv : European journal of physiology 20071201

• PPARalpha and PP2A are involved in the proapoptotic effect of conjugated linoleic acid on human hepatoma cell line SK-HEP-1.

  International journal of cancer 20071201

• PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages.

  British journal of pharmacology 20071201

• Hepatic PGC-1beta overexpression induces combined hyperlipidemia and modulates the response to PPARalpha activation.

  Arteriosclerosis, thrombosis, and vascular biology 20071201

• Peroxisome proliferator-activated receptor-alpha is required for the neurotrophic effect of oleic acid in neurons.

  Journal of neurochemistry 20071101

• Norepinephrine and rosiglitazone synergistically induce Elovl3 expression in brown adipocytes.

  American journal of physiology. Endocrinology and metabolism 20071101

• WY14,643, a PPARalpha ligand, attenuates expression of anti-glomerular basement membrane disease.

  Clinical and experimental immunology 20071101

• Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells.

  European journal of pharmacology 20071001

• Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.

  Circulation 20070918

• Peroxisome proliferator-activated receptor alpha is involved in cardiomyocyte differentiation of murine embryonic stem cells in vitro.

  Cell biology international 20070901

• Cytotoxicity of peroxisome proliferator-activated receptor alpha and gamma agonists in renal proximal tubular cell lines.

  Toxicology in vitro : an international journal published in association with BIBRA 20070901

• The putative tumor suppressor Tsc-22 is downregulated early in chemically induced hepatocarcinogenesis and may be a suppressor of Gadd45b.

  Toxicological sciences : an official journal of the Society of Toxicology 20070901

• Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation.

  Molecular endocrinology (Baltimore, Md.) 20070901

• Different mechanisms of modulation of gap junction communication by non-genotoxic carcinogens in rat liver in vivo.

  Toxicology 20070816

• Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPARalpha activation and oxidative stress.

  Toxicology and applied pharmacology 20070815

• WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase.

  Toxicological sciences : an official journal of the Society of Toxicology 20070801

• The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter.

  Journal of lipid research 20070801

• A role of liver fatty acid-binding protein in cisplatin-induced acute renal failure.

  Kidney international 20070801

• Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists.

  Bioorganic & medicinal chemistry letters 20070801

• Activation of PPARdelta inhibits cardiac fibroblast proliferation and the transdifferentiation into myofibroblasts.

  Cardiovascular research 20070801

• Genome-wide analysis of PPARalpha activation in murine small intestine.

  Physiological genomics 20070718

• Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha.

  Drug metabolism and disposition: the biological fate of chemicals 20070701

• Quinoline-based derivatives of pirinixic acid as dual PPAR alpha/gamma agonists.

  Archiv der Pharmazie 20070701

• Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis.

  The Journal of biological chemistry 20070615

• Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.

  European journal of pharmacology 20070601

• PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes.

  Diabetes 20070601

• Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors.

  Arteriosclerosis, thrombosis, and vascular biology 20070601

• The peroxisome proliferator WY-14,643 promotes hepatocarcinogenesis caused by endogenously generated oxidative DNA base modifications in repair-deficient Csbm/m/Ogg1-/- mice.

  Cancer research 20070601

• The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.

  Journal of hepatology 20070501

• Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors.

  Cellular and molecular life sciences : CMLS 20070501

• Beyond lipids, pharmacological PPARalpha activation has important effects on amino acid metabolism as studied in the rat.

  American journal of physiology. Endocrinology and metabolism 20070401

• Synthesis and evaluation of N-acetyl-L-tyrosine based compounds as PPARalpha selective activators.

  European journal of medicinal chemistry 20070401

• Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function.

  Journal of immunology (Baltimore, Md. : 1950) 20070401

• PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle.

  Biochemical and biophysical research communications 20070323

• Immunoselection and characterization of a human genomic PPAR binding fragment located within POTE genes.

  Biochimie 20070301

• Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation.

  Drug metabolism and disposition: the biological fate of chemicals 20070301

• Tetradecylselenoacetic acid, a PPAR ligand with antioxidant, antiinflammatory, and hypolipidemic properties.

  Arteriosclerosis, thrombosis, and vascular biology 20070301

• PPARalpha agonist induces the accumulation of ceramide in the heart of rats fed high-fat diet.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070301

• Activation of PPARalpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2.

  Biochemical pharmacology 20070215

• Peroxisome proliferator-activated receptor alpha-independent effects of peroxisome proliferators on cysteinyl leukotriene production in mast cells.

  European journal of pharmacology 20070205

• The dominant negative thyroid hormone receptor beta-mutant {Delta}337T alters PPAR{alpha} signaling in heart.

  American journal of physiology. Endocrinology and metabolism 20070201

• Sustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-alpha, but not NADPH oxidase.

  Free radical biology & medicine 20070201

• Activation of peroxisome proliferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism.

  The American journal of pathology 20070201

• Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation.

  Journal of medicinal chemistry 20070125

• Metabolism of phytol to phytanic acid in the mouse, and the role of PPARalpha in its regulation.

  Journal of lipid research 20070101

• Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells.

  Toxicology and applied pharmacology 20070101

• Cardiovascular actions of the peroxisome proliferator-activated receptor-alpha (PPARalpha) agonist Wy14,643.

  Cardiovascular drug reviews 20070101

• In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma and quantitative analysis of in vivo induction pathway.

  Toxicology and applied pharmacology 20061215

• Wy-14,643 and fenofibrate inhibit mitochondrial respiration in isolated rat cardiac mitochondria.

  Mitochondrion 20061201

• Peroxisome proliferator-activated receptor-alpha and glucocorticoids interactively regulate insulin secretion during pregnancy.

  Diabetes 20061201

• Profiling of gene expression in rat liver and rat primary cultured hepatocytes treated with peroxisome proliferators.

  The Journal of toxicological sciences 20061201

• Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor alpha.

  American journal of physiology. Gastrointestinal and liver physiology 20061101

• Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver.

  Hepatology (Baltimore, Md.) 20061101

• Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha.

  Molecular pharmacology 20061001

• Peroxisome proliferator-activated receptor alpha activation during pregnancy severely impairs mammary lobuloalveolar development in mice.

  Endocrinology 20061001

• WY 14,643 inhibits human aldose reductase activity.

  Journal of enzyme inhibition and medicinal chemistry 20061001

• Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain.

  Endocrinology 20060901

• PPARalpha-mediated upregulation of uncoupling protein-2 switches cyanide-induced apoptosis to necrosis in primary cortical cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20060901

• Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity.

  Journal of lipid research 20060901

• Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth.

  Pharmacogenetics and genomics 20060901

• Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators.

  Shock (Augusta, Ga.) 20060901

• Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity.

  Environmental health perspectives 20060901

• Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: effects of the PPAR-alpha agonist WY14643.

  Free radical biology & medicine 20060815

• Activation of peroxisome proliferator-activated receptor alpha enhances apoptosis in the mouse liver.

  Toxicological sciences : an official journal of the Society of Toxicology 20060801

• Agonists of the peroxisome proliferator-activated receptor alpha induce a fiber-type-selective transcriptional response in rat skeletal muscle.

  Toxicological sciences : an official journal of the Society of Toxicology 20060801

• [Influence and mechanism of peroxisome proliferation activated receptor-alpha expression induced by WY14643 in rat lung with acute lung injury].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20060801

• PPARalpha and PPARgamma regulation of liver and adipose proteins in obese and dyslipidemic rodents.

  Journal of proteome research 20060801

• Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist.

  The Journal of biological chemistry 20060707

• The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats.

  British journal of pharmacology 20060701

• Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast.

  Toxicology letters 20060601

• Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.

  The Journal of clinical investigation 20060601

• Differential effects of contraction and PPAR agonists on the expression of fatty acid transporters in rat skeletal muscle.

  The Journal of physiology 20060515

• Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis.

  Carcinogenesis 20060501

• Protection against myocardial ischaemia/reperfusion injury by PPAR-alpha activation is related to production of nitric oxide and endothelin-1.

  Basic research in cardiology 20060501

• PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver.

  Journal of lipid research 20060501

• Synthesis and anti-diabetic activity of (RS)-2-ethoxy-3-{4-[2-(4-trifluoro-methanesulfonyloxy-phenyl)-ethoxy]-phenyl}-propionic acid.

  Acta pharmacologica Sinica 20060501

• Inhibition of hepatocarcinogenesis by the deletion of the p50 subunit of NF-kappaB in mice administered the peroxisome proliferator Wy-14,643.

  Toxicological sciences : an official journal of the Society of Toxicology 20060401

• Fenofibrate activates AMPK and increases eNOS phosphorylation in HUVEC.

  Biochemical and biophysical research communications 20060324

• Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression.

  Endocrinology 20060301

• Effects of fatty acids on skeletal muscle cell differentiation in vitro.

  The British journal of nutrition 20060301

• Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways.

  Biochemical pharmacology 20060227

• PPARalpha activation increases triglyceride mass and adipose differentiation-related protein in hepatocytes.

  Journal of lipid research 20060201

• Ginsenoside Rf, a component of ginseng, regulates lipoprotein metabolism through peroxisome proliferator-activated receptor alpha.

  Biochemical and biophysical research communications 20060106

• Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha.

  Toxicological sciences : an official journal of the Society of Toxicology 20060101

• Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR.

  Drug metabolism and disposition: the biological fate of chemicals 20060101

• Gene expression profiles in rat liver slices exposed to hepatocarcinogenic enzyme inducers, peroxisome proliferators, and 17alpha-ethinylestradiol.

  International journal of toxicology 20060101

• Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists.

  BMC bioinformatics 20060101

• Hepatocellular proliferation in response to agonists of peroxisome proliferator-activated receptor alpha: a role for Kupffer cells?

  Journal of carcinogenesis 20060101

• PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism.

  Biochemical and biophysical research communications 20051230

• PPARalpha activation potentiates AhR-induced CYP1A1 expression.

  Toxicology 20051215

• Peroxisomal proliferation protects from beta-amyloid neurodegeneration.

  The Journal of biological chemistry 20051209

• Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination.

  Diabetes 20051201

• Plasma free fatty acids and peroxisome proliferator-activated receptor alpha in the control of myocardial uncoupling protein levels.

  Diabetes 20051201

• ROLE OF ENDOGENOUS AND EXOGENOUS LIGANDS FOR THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR alpha IN THE DEVELOPMENT OF BLEOMYCIN-INDUCED LUNG INJURY.

  Shock (Augusta, Ga.) 20051201

• The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes.

  The Journal of biological chemistry 20051118

• Statins and PPARalpha agonists induce myotoxicity in differentiated rat skeletal muscle cultures but do not exhibit synergy with co-treatment.

  Toxicology and applied pharmacology 20051101

• Synthesis of new carbo- and heterocyclic analogues of 8-HETE and evaluation of their activity towards the PPARs.

  Bioorganic & medicinal chemistry letters 20051015

• Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.

  Clinical chemistry 20051001

• Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity.

  American journal of physiology. Regulatory, integrative and comparative physiology 20050901

• A teleost in vitro reporter gene assay to screen for agonists of the peroxisome proliferator-activated receptors.

  Environmental toxicology and chemistry 20050901

• Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity.

  Journal of medicinal chemistry 20050825

• Comparison of the expression profiles induced by genotoxic and nongenotoxic carcinogens in rat liver.

  Mutation research 20050804

• Regulation of peroxisome proliferator-activated receptor alpha by protein kinase C.

  Biochemistry 20050802

• Anti-inflammatory effect of fibrate protects from cisplatin-induced ARF.

  American journal of physiology. Renal physiology 20050801

• Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells.

  Endocrinology 20050801

• Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia.

  Journal of neuroscience research 20050801

• A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver.

  The Biochemical journal 20050715

• Evaluation of cytochrome P450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells.

  Life sciences 20050715

• Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors.

  The Journal of pharmacology and experimental therapeutics 20050701

• Adiponectin receptor gene expression in human skeletal muscle cells is not regulated by fibrates and thiazolidinediones.

  International journal of obesity (2005) 20050701

• Peroxisome proliferator-activated receptor alpha and its response element are required but not sufficient for transcriptional activation of the mouse heart-type fatty acid binding protein gene.

  The international journal of biochemistry & cell biology 20050701

• A new retinoid-like compound that activates peroxisome proliferator-activated receptors and lowers blood glucose in diabetic mice.

  Biological & pharmaceutical bulletin 20050701

• Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats.

  Neuropharmacology 20050601

• Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition.

  Cancer research 20050515

• Peroxisome proliferator-activated receptor alpha physically interacts with CCAAT/enhancer binding protein (C/EBPbeta) to inhibit C/EBPbeta-responsive alpha1-acid glycoprotein gene expression.

  Molecular endocrinology (Baltimore, Md.) 20050501

• Conditional regulation of the human CYP4X1 and CYP4Z1 genes.

  Archives of biochemistry and biophysics 20050415

• Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor.

  Molecular pharmacology 20050401

• Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases.

  Journal of lipid research 20050401

• Future strategies in the treatment of acute renal failure: growth factors, stem cells, and other novel therapies.

  Current opinion in pediatrics 20050401

• Unique patterns of gene expression changes in liver after treatment of mice for 2 weeks with different known carcinogens and non-carcinogens.

  Carcinogenesis 20050301

• Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.

  Archives of biochemistry and biophysics 20050201

• Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists.

  The Journal of biological chemistry 20050128

• Activation of peroxisome proliferator-activated receptor alpha increases the expression and activity of microsomal triglyceride transfer protein in the liver.

  The Journal of biological chemistry 20050114

• Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis.

  Carcinogenesis 20050101

• The peroxisome proliferator-activated receptor alpha activator, Wy14,643, is anti-inflammatory in vivo.

  Inflammopharmacology 20050101

• Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.

  Journal of biochemical and molecular toxicology 20050101

• The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes.

  The Journal of biological chemistry 20041210

• Peroxisome proliferator-activated receptor alpha induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-alpha activation properties.

  Circulation research 20041210

• Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver.

  Molecular pharmacology 20041201

• Peroxisome proliferator-activated receptor alpha regulates B lymphocyte development via an indirect pathway in mice.

  Biochemical pharmacology 20041201

• PPARalpha ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats.

  Biochemical and biophysical research communications 20041112

• Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle.

  American journal of physiology. Endocrinology and metabolism 20041101

• alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers.

  The American journal of pathology 20041101

• Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites.

  Gastroenterology 20041101

• Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors.

  The Journal of biological chemistry 20041029

• Statin induction of liver fatty acid-binding protein (L-FABP) gene expression is peroxisome proliferator-activated receptor-alpha-dependent.

  The Journal of biological chemistry 20041029

• PPARalpha activators down-regulate CYP2C7, a retinoic acid and testosterone hydroxylase.

  Toxicology 20041015

• Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver.

  Toxicology 20041015

• Integrated genomic and proteomic analyses of gene expression in Mammalian cells.

  Molecular & cellular proteomics : MCP 20041001

• WY 14643, a potent exogenous PPAR-alpha ligand, reduces intestinal injury associated with splanchnic artery occlusion shock.

  Shock (Augusta, Ga.) 20041001

• Enhancement of insulin signaling through inhibition of tissue lipid accumulation by activation of peroxisome proliferator-activated receptor (PPAR) alpha in obese mice.

  Medical science monitor : international medical journal of experimental and clinical research 20041001

• 17beta-hydroxysteroid dehydrogenase type 11 is a major peroxisome proliferator-activated receptor alpha-regulated gene in mouse intestine.

  European journal of biochemistry 20041001

• Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro.

  The British journal of dermatology 20041001

• Beneficial and deleterious effects of rosiglitazone on hypertension development in spontaneously hypertensive rats.

  American journal of hypertension 20040901

• PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.

  Regulatory peptides 20040815

• Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha.

  Alcohol (Fayetteville, N.Y.) 20040801

• Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons.

  Journal of neuroscience research 20040715

• Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators.

  Bioorganic & medicinal chemistry letters 20040705

• Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes.

  Biochimica et biophysica acta 20040705

• Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha).

  The Journal of biological chemistry 20040702

• Dissociation of oxidant production by peroxisome proliferator-activated receptor ligands from cell death in human cell lines.

  Free radical biology & medicine 20040701

• Protein profiling of mouse livers with peroxisome proliferator-activated receptor alpha activation.

  Molecular and cellular biology 20040701

• WY-14643 and 9- cis-retinoic acid induce IRS-2/PI 3-kinase signalling pathway and increase glucose transport in human skeletal muscle cells: differential effect in myotubes from healthy subjects and Type 2 diabetic patients.

  Diabetologia 20040701

• Different ways to regulate the PPARalpha stability.

  Biochemical and biophysical research communications 20040625

• Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver.

  The Journal of biological chemistry 20040604

• Coadministration of a liver X receptor agonist and a peroxisome proliferator activator receptor-alpha agonist in Mice: effects of nuclear receptor interplay on high-density lipoprotein and triglyceride metabolism in vivo.

  The Journal of pharmacology and experimental therapeutics 20040601

• Differential regulation of cytosolic and peroxisomal bile acid amidation by PPAR alpha activation favors the formation of unconjugated bile acids.

  Journal of lipid research 20040601

• Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha.

  Cancer research 20040601

• The human semaphorin 6B gene is down regulated by PPARs.

  Genomics 20040601

• Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases.

  The Journal of biological chemistry 20040521

• Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1.

  The Journal of biological chemistry 20040521

• Modulation of PPARalpha expression and inflammatory interleukin-6 production by chronic glucose increases monocyte/endothelial adhesion.

  Arteriosclerosis, thrombosis, and vascular biology 20040501

• Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice.

  Hepatology (Baltimore, Md.) 20040501

• Cardiovascular drugs inhibit MMP-9 activity from human THP-1 macrophages.

  DNA and cell biology 20040501

• Peroxisome proliferator-activated receptor-alpha regulates postischemic liver injury.

  American journal of physiology. Gastrointestinal and liver physiology 20040401

• Peroxisome proliferator-activated receptor alpha agonists increase nitric oxide synthase expression in vascular endothelial cells.

  Arteriosclerosis, thrombosis, and vascular biology 20040401

• Characterization of the species-specificity of peroxisome proliferators in rat and human hepatocytes.

  Toxicological sciences : an official journal of the Society of Toxicology 20040401

• Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level.

  The Biochemical journal 20040315

• PPAR alpha ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity.

  American journal of physiology. Renal physiology 20040301

• Reduction of palmitate-induced cardiac apoptosis by fenofibrate.

  Molecular and cellular biochemistry 20040301

• PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation.

  Circulation research 20040220

• Catalase transgenic mice: characterization and sensitivity to oxidative stress.

  Archives of biochemistry and biophysics 20040215

• Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators.

  Cancer research 20040201

• Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells.

  Immunity 20040201

• 15-Deoxy-delta(12,14)-prostaglandin J2 inhibits the IL-1beta-induced expression of granulocyte-macrophage colony-stimulating factor in BEAS-2B bronchial epithelial cells.

  The Tohoku journal of experimental medicine 20040201

• Hepatocarcinogenesis by peroxisome proliferators.

  The Journal of toxicological sciences 20040201

• Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR.

  Biochemical and biophysical research communications 20040130

• Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes.

  Biochemical and biophysical research communications 20040109

• Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth.

  Biochemical pharmacology 20040101

• Relationship between PPARalpha activation and NO on proximal tubular Na+ transport in the rat.

  BMC pharmacology 20040101

• Peroxisome proliferator-activated receptor agonists inhibit interleukin-1beta-mediated nitric oxide production in cultured lacrimal gland acinar cells.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201

• Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice.

  Journal of lipid research 20031101

• Induction of plasminogen activator inhibitor I by the PPARalpha ligand, Wy-14,643, is dependent on ERK1/2 signaling pathway.

  Thrombosis and haemostasis 20031001

• WY-14,643-mediated promotion of hepatocarcinogenesis in connexin32-wild-type and connexin32-null mice.

  Carcinogenesis 20030901

• Assessment of hepatocytes and liver slices as in vitro test systems to predict in vivo gene expression.

  Toxicological sciences : an official journal of the Society of Toxicology 20030901

• Peroxisome proliferator activated receptor (PPAR)alpha agonists inhibit hypertrophy of neonatal rat cardiac myocytes.

  Endocrinology 20030901

• Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme.

  The Journal of biological chemistry 20030829

• Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice.

  The Journal of biological chemistry 20030725

• Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice.

  American journal of physiology. Heart and circulatory physiology 20030701

• Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.

  Molecular endocrinology (Baltimore, Md.) 20030701

• Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis.

  Diabetes 20030701

• Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice.

  Hepatology (Baltimore, Md.) 20030701

• Bezafibrate is a dual ligand for PPARalpha and PPARbeta: studies using null mice.

  Biochimica et biophysica acta 20030610

• Identification of hepatic transcriptional changes in insulin-resistant rats treated with peroxisome proliferator activated receptor-alpha agonists.

  Journal of molecular endocrinology 20030601

• Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators.

  The Journal of biological chemistry 20030516

• Increased expression of the lipocalin 24p3 as an apoptotic mechanism for MK886.

  The Biochemical journal 20030515

• Activation-induced PPARgamma expression sensitizes primary human T cells toward apoptosis.

  Journal of leukocyte biology 20030501

• Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643.

  Toxicology and applied pharmacology 20030501

• Acute (24 h) activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) reverses high-fat feeding-induced insulin hypersecretion in vivo and in perifused pancreatic islets.

  The Journal of endocrinology 20030501

• Dysregulation of DNA repair pathways in a transforming growth factor alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis.

  Laboratory investigation; a journal of technical methods and pathology 20030501

• Hepatic protein expression of lean mice and obese diabetic mice treated with peroxisome proliferator-activated receptor activators.

  Proteomics 20030401

• Protein expression changes in the Sprague Dawley rat liver proteome following administration of peroxisome proliferator activated receptor alpha and gamma ligands.

  Proteomics 20030401

• Peroxisome proliferator-activated receptor alpha is involved in the regulation of lipid metabolism by ginseng.

  British journal of pharmacology 20030401

• Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643.

  Carcinogenesis 20030401

• Activation of peroxisome proliferator-activated receptors alpha and gamma1 inhibits human smooth muscle cell proliferation.

  Molecular and cellular biochemistry 20030401

• 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism.

  Biochemical and biophysical research communications 20030307

• PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly.

  American journal of physiology. Endocrinology and metabolism 20030301

• Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy.

  Journal of immunology (Baltimore, Md. : 1950) 20030301

• PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway.

  Journal of the American Society of Nephrology : JASN 20030301

• Age-dependent effects of nongenotoxic hepatocarcinogens on liver apoptosis in vivo.

  Mechanisms of ageing and development 20030301

• Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages.

  Circulation research 20030207

• Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice.

  The Biochemical journal 20030201

• Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone.

  The Biochemical journal 20030201

• Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes.

  Journal of dermatological science 20030201

• Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes.

  The Journal of biological chemistry 20030103

• Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone.

  Archives of biochemistry and biophysics 20030101

• Peroxisome proliferator-activated receptor-alpha activation during pregnancy attenuates glucose-stimulated insulin hypersecretion in vivo by increasing insulin sensitivity, without impairing pregnancy-induced increases in beta-cell glucose sensing and responsiveness.

  Endocrinology 20030101

• Delayed induction of delta-6 and delta-5 desaturases by a peroxisome proliferator.

  Biochemical and biophysical research communications 20021220

• WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivo.

  Journal of immunology (Baltimore, Md. : 1950) 20021215

• Non-genotoxic carcinogens: early effects on gap junctions, cell proliferation and apoptosis in the rat.

  Toxicology 20021202

• Peroxisome proliferator-activated receptor activators inhibit oxidized low-density lipoprotein-induced endothelin-1 secretion in endothelial cells.

  Journal of cardiovascular pharmacology 20021201

• Agonists of peroxisome-proliferator activated receptor-alpha (clofibrate and WY14643) reduce renal ischemia/reperfusion injury in the rat.

  Medical science monitor : international medical journal of experimental and clinical research 20021201

• Hepatic expression of polymerase beta, Ref-1, PCNA, and Bax in WY 14,643-exposed rats and hamsters.

  Experimental and molecular pathology 20021201

• PPAR-alpha ligands inhibit H2O2-mediated activation of transforming growth factor-beta1 in human mesangial cells.

  Antioxidants & redox signaling 20021201

• PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4.

  Circulation research 20021129

• Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms.

  Archives of biochemistry and biophysics 20021115

• AZ 242, a novel PPARalpha/gamma agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats.

  Journal of lipid research 20021101

• A metabolic switching hypothesis for the first step in the hypolipidemic effects of fibrates.

  Biological & pharmaceutical bulletin 20021101

• PPAR alpha stimulates the rat gastrin-producing cell.

  Molecular and cellular endocrinology 20020930

• Peroxisome proliferator-activated receptor ligands negatively regulate the expression of the high-affinity IgE receptor Fc epsilon RI in human basophilic KU812 cells.

  Biochemical and biophysical research communications 20020920

• Inhibition of cytokine-induced matrix metalloproteinase 9 expression by peroxisome proliferator-activated receptor alpha agonists is indirect and due to a NO-mediated reduction of mRNA stability.

  The Journal of biological chemistry 20020906

• PPAR agonists amplify iNOS expression while inhibiting NF-kappaB: implications for mesangial cell activation by cytokines.

  Journal of the American Society of Nephrology : JASN 20020901

• Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices.

  Xenobiotica; the fate of foreign compounds in biological systems 20020901

• Effects of the rat hepatic peroxisome proliferator, Wyeth 14,643, on the lactating goat.

  Drug and chemical toxicology 20020801

• Peroxisome proliferator-activated receptor alpha in the human breast cancer cell lines MCF-7 and MDA-MB-231.

  Molecular carcinogenesis 20020801

• Interactions of fluorochemicals with rat liver fatty acid-binding protein.

  Toxicology 20020715

• WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice.

  The Journal of biological chemistry 20020705

• Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020701

• Ligands of the peroxisome proliferator-activated receptor-PPAR-a reduce myocardial infarct size.

  Medical science monitor : international medical journal of experimental and clinical research 20020701

• Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts.

  Toxicology and applied pharmacology 20020701

• Advantages of glutamate dehydrogenase as a blood biomarker of acute hepatic injury in rats.

  Laboratory animals 20020701

• Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48.

  The Journal of biological chemistry 20020621

• Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2.

  Brain research 20020621

• Gene expression analysis reveals chemical-specific profiles.

  Toxicological sciences : an official journal of the Society of Toxicology 20020601

• Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma.

  Journal of neurochemistry 20020601

• Peroxisome proliferator-activated receptor agonists inhibit inflammatory edema and hyperalgesia.

  Inflammation 20020601

• PPAR activators inhibit endothelial cell migration by targeting Akt.

  Biochemical and biophysical research communications 20020524

• Involvement of the peroxisome proliferator-activated receptor alpha in the immunomodulation caused by peroxisome proliferators in mice.

  Biochemical pharmacology 20020515

• Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells.

  Atherosclerosis 20020501

• Selective inhibition of cyclooxygenase-2 expression by 15-deoxy-Delta(12,14)(12,14)-prostaglandin J(2) in activated human astrocytes, but not in human brain macrophages.

  Journal of immunology (Baltimore, Md. : 1950) 20020501

• Comparative effects of phthalate monoesters on gap junctional intercellular communication and peroxisome proliferation in rodent and primate hepatocytes.

  Journal of toxicology and environmental health. Part A 20020426

• PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis.

  Circulation research 20020405

• Peroxisome proliferators activate growth regulatory pathways largely via peroxisome proliferator-activated receptor alpha-independent mechanisms.

  Cellular signalling 20020401

• Mechanism for peroxisome proliferator-activated receptor-alpha activator-induced up-regulation of UCP2 mRNA in rodent hepatocytes.

  The Journal of biological chemistry 20020315

• Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors.

  Journal of immunology (Baltimore, Md. : 1950) 20020315

• Potentiation of TNF-alpha-stimulated group IIA phospholipase A(2) expression by peroxisome proliferator-activated receptor alpha activators in rat mesangial cells.

  Journal of the American Society of Nephrology : JASN 20020301

• Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.

  Journal of medicinal chemistry 20020214

• The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020201

• Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin.

  Diabetes 20020201

• Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism.

  Arthritis and rheumatism 20020201

• Characterization of the adipose tissue atrophy induced by peroxisome proliferators in mice.

  Lipids 20020201

• Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator- activated receptor alpha agonists.

  Biochemical and biophysical research communications 20020125

• PPARalpha and PPARdelta activators inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells.

  European journal of pharmacology 20020125

• Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism.

  The Journal of biological chemistry 20020111

• Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models.

  The Journal of investigative dermatology 20020101

• Effect of peroxisome proliferators on the methylation and protein level of the c-myc protooncogene in B6C3F1 mice liver.

  Journal of biochemical and molecular toxicology 20020101

• Profiling of acyl-CoA oxidase-deficient and peroxisome proliferator Wy14,643-treated mouse liver protein by surface-enhanced laser desorption/ionization ProteinChip Biology System.

  Gene expression 20020101

• The transcription of the peroxisome proliferator-activated receptor alpha gene is regulated by protein kinase C.

  Toxicology letters 20011215

• Antagonism of the actions of peroxisome proliferator-activated receptor-alpha by bile acids.

  The Journal of biological chemistry 20011214

• Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion.

  Diabetes 20011201

• Peroxisome proliferator-activated receptor alpha (PPAR alpha) agonist, WY-14,643, increased transcription of myosin light chain-2 in cardiomyocytes.

  The Journal of toxicological sciences 20011201

• Activators of peroxisome proliferator-activated receptors protect human skin from ultraviolet-B-light-induced inflammation.

  The Journal of investigative dermatology 20011201

• Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart.

  The Journal of biological chemistry 20011130

• Human peroxisome proliferator-activated receptor alpha (PPARalpha) supports the induction of peroxisome proliferation in PPARalpha-deficient mouse liver.

  The Journal of biological chemistry 20011109

• Hepatocellular proliferation in response to a peroxisome proliferator does not require TNFalpha signaling.

  Carcinogenesis 20011101

• Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression.

  Arteriosclerosis, thrombosis, and vascular biology 20011101

• Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development.

  Molecular genetics and metabolism 20011101

• Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines.

  The Journal of biological chemistry 20011019

• Stabilization of peroxisome proliferator-activated receptor alpha by the ligand.

  Biochemical and biophysical research communications 20011019

• Activation of the peroxisome proliferator-activated receptor-alpha enhances cell death in cultured cerebellar granule cells.

  Journal of neuroscience research 20011015

• Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha.

  Biochemical and biophysical research communications 20010921

• Comparison of the mutant frequencies and mutation spectra of three non-genotoxic carcinogens, oxazepam, phenobarbital, and Wyeth 14,643, at the lambdacII locus in Big Blue transgenic mice.

  Biochemical pharmacology 20010915

• Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta.

  The Journal of biological chemistry 20010907

• Phenobarbital, oxazepam and Wyeth 14,643 cause DNA damage as measured by the Comet assay.

  Mutagenesis 20010901

• Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice.

  Biochemical and biophysical research communications 20010831

• Effects of bezafibrate on beta-cell function of rat pancreatic islets.

  European journal of pharmacology 20010831

• Altered expression of the carboxylesterases ES-4 and ES-10 by peroxisome proliferator chemicals.

  Toxicology 20010828

• Regulation of p85alpha phosphatidylinositol-3-kinase expression by peroxisome proliferator-activated receptors (PPARs) in human muscle cells.

  FEBS letters 20010803

• (-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity.

  Journal of medicinal chemistry 20010802

• Peroxisome proliferator-activated receptor-alpha ligands inhibit cardiac lipoprotein lipase activity.

  American journal of physiology. Heart and circulatory physiology 20010801

• PPARalpha-dependent induction of liver microsomal esterification of estradiol and testosterone by a prototypical peroxisome proliferator.

  Endocrinology 20010801

• Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells.

  The Journal of biological chemistry 20010727

• Identification of a peroxisome-proliferator-activated-receptor response element in the apolipoprotein E gene control region.

  The Biochemical journal 20010715

• Inhibitors of arachidonic acid metabolism potentiate tumour necrosis factor-alpha-induced apoptosis in HL-60 cells.

  European journal of pharmacology 20010713

• Differential activation of hepatic NF-kappaB in rats and hamsters by the peroxisome proliferators Wy-14,643, gemfibrozil, and dibutyl phthalate.

  Toxicological sciences : an official journal of the Society of Toxicology 20010701

• Wy-14,643-induced hypomethylation of the c-myc gene in mouse liver.

  Toxicological sciences : an official journal of the Society of Toxicology 20010701

• Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells.

  Experimental cell research 20010701

• Cloning of the human cholesteryl ester hydrolase promoter: identification of functional peroxisomal proliferator-activated receptor responsive elements.

  Biochemical and biophysical research communications 20010622

• Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia.

  Journal of immunology (Baltimore, Md. : 1950) 20010615

• Evidence that reduction of hepatocyte growth factor (HGF) is not required for peroxisome proliferator-induced hepatocyte proliferation.

  Carcinogenesis 20010601

• The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor alpha-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal beta-oxidation enzymes acyl-CoA oxidase and hydratase-dehydrogenase.

  Molecular and cellular endocrinology 20010515

• Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells.

  Toxicology and applied pharmacology 20010501

• PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice.

  The Journal of clinical investigation 20010415

• Effects of peroxisome proliferators on antioxidant enzymes and antioxidant vitamins in rats and hamsters.

  Toxicological sciences : an official journal of the Society of Toxicology 20010401

• Differential regulation of expression of genes encoding uncoupling proteins 2 and 3 in brown adipose tissue during lactation in mice.

  The Biochemical journal 20010401

• The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis.

  European journal of immunology 20010401

• WY-14,643 and other agonists of the peroxisome proliferator-activated receptor reveal a new mode of action for salicylic acid in soybean disease resistance.

  Planta 20010401

• Peroxisome proliferators and fatty acids negatively regulate liver X receptor-mediated activity and sterol biosynthesis.

  The Journal of steroid biochemistry and molecular biology 20010401

• Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids.

  American journal of physiology. Endocrinology and metabolism 20010301

• Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats.

  Toxicological sciences : an official journal of the Society of Toxicology 20010301

• Tumor necrosis factor alpha is not required for WY14,643-induced cell proliferation.

  Carcinogenesis 20010301

• Peroxisome proliferators do not increase DNA synthesis in purified rat hepatocytes.

  Carcinogenesis 20010301

• Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010301

• Effects of peroxisome proliferators on glutathione and glutathione-related enzymes in rats and hamsters.

  Toxicology and applied pharmacology 20010215

• Delayed activation of PPARgamma by LPS and IFN-gamma attenuates the oxidative burst in macrophages.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010201

• PPARalpha agonists inhibit tissue factor expression in human monocytes and macrophages.

  Circulation 20010116

• PPARalpha activators inhibit tissue factor expression and activity in human monocytes.

  Circulation 20010116

• Fatty-acyl-CoA thioesters inhibit recruitment of steroid receptor co-activator 1 to alpha and gamma isoforms of peroxisome-proliferator-activated receptors by competing with agonists.

  The Biochemical journal 20010115

• Dexamethasone selectively inhibits WY14,643-induced cell proliferation and not peroxisome proliferation in mice.

  Toxicology and applied pharmacology 20010115

• Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates.

  Biochimica et biophysica acta 20010115

• Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell.

  The Journal of biological chemistry 20010112

• The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver.

  The Journal of biological chemistry 20010105

• Expression of the mRNA encoding truncated PPAR alpha does not correlate with hepatic insensitivity to peroxisome proliferators.

  Molecular and cellular biochemistry 20010101

• Therapeutic treatment of DMBA-induced mammary tumors with PPAR ligands.

  Anticancer research 20010101

• Unique renal tubule changes induced in rats and mice by the peroxisome proliferators 2,4-dichlorophenoxyacetic acid (2,4-D) and WY-14643.

  Toxicologic pathology 20010101

• Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis.

  Gene expression 20010101

• 15-Deoxy-Delta(12,14)-prostaglandin J(2) facilitates thyroglobulin production by cultured human thyrocytes.

  American journal of physiology. Cell physiology 20001201

• Down-regulation of uncoupling protein-3 and -2 by thiazolidinediones in C2C12 myotubes.

  FEBS letters 20001027

• Keratinocyte differentiation in hyperproliferative epidermis: topical application of PPARalpha activators restores tissue homeostasis.

  The Journal of investigative dermatology 20000901

• Peroxisome proliferator-activated receptor alpha (PPARalpha) activators, bezafibrate and Wy-14,643, increase uncoupling protein-3 mRNA levels without modifying the mitochondrial membrane potential in primary culture of rat preadipocytes.

  Archives of biochemistry and biophysics 20000815

• Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene.

  Diabetes 20000701

• Evidence against the peroxisome proliferator-activated receptor alpha (PPARalpha) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription.

  Journal of lipid research 20000501

• The PPARs: from orphan receptors to drug discovery.

  Journal of medicinal chemistry 20000224

• The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes.

  Cell biology and toxicology 20000101

• trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals.

  Toxicology and applied pharmacology 19991201

• PPARalpha activation by Wy 14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARgamma-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes.

  Biochemical and biophysical research communications 19991022

• Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice.

  Carcinogenesis 19990801

• Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha.

  Biochemical and biophysical research communications 19990714

• Rosiglitazone (BRL49653), a PPARgamma-selective agonist, causes peroxisome proliferator-like liver effects in obese mice.

  Journal of lipid research 19990701

• Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth.

  Diabetes 19990601

• Effects of fibrate compounds on expression of plasminogen activator inhibitor-1 by cultured endothelial cells.

  Arteriosclerosis, thrombosis, and vascular biology 19990601

• A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats.

  Diabetes 19981201

• Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha.

  Thrombosis and haemostasis 19981201

• Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids.

  Environmental health perspectives 19980801

• Dietary glycine prevents increases in hepatocyte proliferation caused by the peroxisome proliferator WY-14,643.

  Chemical research in toxicology 19971001

• PPAR alpha structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents.

  Biological chemistry 19970701

• Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs.

  The Journal of biological chemistry 19970207

• Induction of cyclooxygenase-2 expression by peroxisome proliferators and non-tetradecanoylphorbol 12,13-myristate-type tumor promoters in immortalized mouse liver cells.

  The Journal of biological chemistry 19970207

• Peroxisome proliferators alter the expression of estrogen-metabolizing enzymes.

  Biochimie 19970101

• Molecular profiling of non-genotoxic hepatocarcinogenesis using differential display reverse transcription-polymerase chain reaction (ddRT-PCR).

  European journal of drug metabolism and pharmacokinetics 19970101

• The PPARalpha-leukotriene B4 pathway to inflammation control.

  Nature 19961107

• Growth regulation by peroxisome proliferators: opposing activities in early and late G1.

  Cancer research 19960715

• Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate.

  Molecular pharmacology 19960701

• A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation.

  Cell 19951201

• Gemfibrozil-induced peroxisome proliferation and hepatomegaly in male F344 rats.

  Cancer letters 19951106

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  Environmental health perspectives 19931201

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  Biochemistry 19930601

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  Toxicology and applied pharmacology 19830101

• Enhancement by Wy-14,643, a hepatic peroxisome proliferator, of diethylnitrosamine-initiated hepatic tumorigenesis in the rat.

  British journal of cancer 19781001