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Expression of cytochrome P450 epoxygenases and soluble epoxide hydrolase is regulated by hypolipidemic drugs in dose-dependent manner.
Toxicology and applied pharmacology 20180915
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PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling.
Toxicology 20170715
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The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARα down-regulation.
Toxicology 20170615
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Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.
Archives of toxicology 20170501
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Antidiabetic effect of SN158 through PPARα/γ dual activation in ob/ob mice.
Chemico-biological interactions 20170425
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Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis.
Toxicology 20170301
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Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models.
Toxicology and applied pharmacology 20170301
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Activation of the Constitutive Androstane Receptor by Monophthalates.
Chemical research in toxicology 20161017
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Activation of peroxisome proliferator-activated receptor α ameliorates perfluorododecanoic acid-induced production of reactive oxygen species in rat liver.
Archives of toxicology 20160601
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Effects of Crude Oil/Dispersant Mixture and Dispersant Components on PPARγ Activity in Vitro and in Vivo: Identification of Dioctyl Sodium Sulfosuccinate (DOSS; CAS #577-11-7) as a Probable Obesogen.
Environmental health perspectives 20160101
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Transcriptome analyses demonstrate that Peroxisome Proliferator-Activated Receptor α (PPARα) activity of an ultraviolet absorber, 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole, as possible mechanism of their toxicity and the gender differences.
The Journal of toxicological sciences 20160101
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A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.
Archives of toxicology 20151201
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Activation of sterol regulatory element-binding proteins in mice exposed to perfluorooctanoic acid for 28Â days.
Archives of toxicology 20150901
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Oxidative Stress Mechanisms Do Not Discriminate between Genotoxic and Nongenotoxic Liver Carcinogens.
Chemical research in toxicology 20150817
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Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability.
Toxicological sciences : an official journal of the Society of Toxicology 20150501
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Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium.
PloS one 20150101
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Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium.
Nuclear receptor signaling 20150101
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Role of the ubiquitin-proteasome system in cardiac dysfunction of adipose triglyceride lipase-deficient mice.
Journal of molecular and cellular cardiology 20141201
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Fish oil and fenofibrate prevented phosphorylation-dependent hepatic sortilin 1 degradation in Western diet-fed mice.
The Journal of biological chemistry 20140808
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Sargahydroquinoic acid inhibits TNFα-induced AP-1 and NF-κB signaling in HaCaT cells through PPARα activation.
Biochemical and biophysical research communications 20140808
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Resveratrol and its metabolites bind to PPARs.
Chembiochem : a European journal of chemical biology 20140526
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Evaluating the additivity of perfluoroalkyl acids in binary combinations on peroxisome proliferator-activated receptor-α activation.
Toxicology 20140227
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Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action.
PloS one 20140101
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PPARα-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons.
The Journal of steroid biochemistry and molecular biology 20131101
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Normalization strategies for gene expression studies by real-time PCR in a marine fish species, Scophthalmus maximus.
Marine genomics 20130601
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Identification of transcription factors and coactivators affected by dibutylphthalate interactions in fetal rat testes.
Toxicological sciences : an official journal of the Society of Toxicology 20130401
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Detection of genotoxic and non-genotoxic carcinogens in Xpc(-/-)p53(+/-) mice.
Toxicology and applied pharmacology 20130115
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Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.
PloS one 20130101
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Perfluorooctanoic acid induced-developmental cardiotoxicity: are peroxisome proliferator activated receptor α (PPARα) and bone morphorgenic protein 2 (BMP2) pathways involved?
Journal of toxicology and environmental health. Part A 20130101
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Wy14643 improves vascular function in the aorta of the spontaneously hypertensive rat mainly by activating peroxisome proliferator-activated receptors alpha.
European journal of pharmacology 20121205
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APOA5 gene expression in the human intestinal tissue and its response to in vitro exposure to fatty acid and fibrate.
Nutrition, metabolism, and cardiovascular diseases : NMCD 20120901
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Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver.
Archives of toxicology 20120901
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Assessment of possible carcinogenicity of oxyfluorfen to humans using mode of action analysis of rodent liver effects.
Toxicological sciences : an official journal of the Society of Toxicology 20120801
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PPAR-alpha activation as a preconditioning-like intervention in rats in vivo confers myocardial protection against acute ischaemia-reperfusion injury: involvement of PI3K-Akt.
Canadian journal of physiology and pharmacology 20120801
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Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells.
Cell death and differentiation 20120701
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Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity.
Hepatology (Baltimore, Md.) 20120701
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Topical application of PPARα (but not β/δ or γ) suppresses atopic dermatitis in NC/Nga mice.
Allergy 20120701
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Total synthesis and dual PPARα/γ agonist effects of amorphastilbol and its synthetic derivatives.
Bioorganic & medicinal chemistry letters 20120615
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Cytokine production by infrapatellar fat pad can be stimulated by interleukin 1β and inhibited by peroxisome proliferator activated receptor α agonist.
Annals of the rheumatic diseases 20120601
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Co-treatment with retinyl retinoate and a PPARα agonist reduces retinoid dermatitis.
International journal of dermatology 20120601
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Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart.
Physiological genomics 20120319
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Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists.
Bioorganic & medicinal chemistry 20120315
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Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARα and CAR/PXR.
Toxicology 20120311
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PPARα and PPARγ regulate the nucleoside transporter hENT1.
Biochemical and biophysical research communications 20120309
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Peroxisome proliferator-activated receptor-α agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis.
Journal of gastroenterology and hepatology 20120201
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Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potency.
Toxicological sciences : an official journal of the Society of Toxicology 20120201
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Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer.
PLoS computational biology 20120201
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Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.
Journal of medicinal chemistry 20120112
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Cardiac dysfunction in adipose triglyceride lipase deficiency: treatment with a PPARα agonist.
British journal of pharmacology 20120101
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Fine metabolic regulation in ruminants via nutrient-gene interactions: saturated long-chain fatty acids increase expression of genes involved in lipid metabolism and immune response partly through PPAR-α activation.
The British journal of nutrition 20120101
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Fenofibrate down-regulates renal OCT2-mediated organic cation transport via PPARα-independent pathways.
Drug metabolism and pharmacokinetics 20120101
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Combining ZHENG Theory and High-Throughput Expression Data to Predict New Effects of Chinese Herbal Formulae.
Evidence-based complementary and alternative medicine : eCAM 20120101
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Organotypic modeling of human keratinocyte response to peroxisome proliferators.
Cells, tissues, organs 20120101
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Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction.
PloS one 20120101
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In Vitro and In Vivo Characterizations of Chiglitazar, a Newly Identified PPAR Pan-Agonist.
PPAR research 20120101
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Tertiary alkylamines as nucleophiles in substitution reactions at heteroaromatic halide during the synthesis of the highly potent pirinixic acid derivative 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS-121).
Molecules (Basel, Switzerland) 20111205
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Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity.
Toxicological sciences : an official journal of the Society of Toxicology 20111201
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Adiponectin reduces connective tissue growth factor in human hepatocytes which is already induced in non-fibrotic non-alcoholic steatohepatitis.
Experimental and molecular pathology 20111201
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Efficacy of combined peroxisome proliferator-activated receptor-α ligand and glucocorticoid therapy in a murine model of atopic dermatitis.
The Journal of investigative dermatology 20110901
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PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation.
Biochimica et biophysica acta 20110801
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A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm.
British journal of pharmacology 20110801
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Peroxisome proliferator activated receptor alpha activation decreases inflammatory and destructive responses in osteoarthritic cartilage.
Osteoarthritis and cartilage 20110701
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Differential regulation of bovine pyruvate carboxylase promoters by fatty acids and peroxisome proliferator-activated receptor-α agonist.
Journal of dairy science 20110701
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Effects of chronic systemic treatment with peroxisome proliferator-activated receptor α activators on neuroinflammation induced by intracerebral injection of lipopolysaccharide in adult mice.
Neuroscience research 20110601
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20-Hydroxyeicosatetraenoic acid inhibits ATP-induced COX-2 expression via peroxisome proliferator activator receptor-α in vascular smooth muscle cells.
British journal of pharmacology 20110601
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Revisiting glitazars: thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives as highly potent PPARα/γ dual agonists devoid of adverse effects in rodents.
Bioorganic & medicinal chemistry letters 20110515
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Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin Eâ‚‚ synthase-1 (mPGES-1).
Journal of medicinal chemistry 20110512
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A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver.
Biochimie 20110501
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Lack of PPARα exacerbates lipopolysaccharide-induced liver toxicity through STAT1 inflammatory signaling and increased oxidative/nitrosative stress.
Toxicology letters 20110410
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PPARα agonist prevented the apoptosis induced by glucose and fatty acid in neonatal cardiomyocytes.
Journal of endocrinological investigation 20110401
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Fenofibrate suppresses microvascular inflammation and apoptosis through adenosine monophosphate-activated protein kinase activation.
Metabolism: clinical and experimental 20110401
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Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors.
Biological psychiatry 20110401
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A novel class of dual mPGES-1/5-LO inhibitors based on the α-naphthyl pirinixic acid scaffold.
Bioorganic & medicinal chemistry letters 20110301
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Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists.
Bioorganic & medicinal chemistry 20110115
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26-Week carcinogenicity study of di-isodecyl phthalate by dietary administration to CB6F1-rasH2 transgenic mice.
Archives of toxicology 20110101
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Activation of peroxisome proliferator-activated receptor α in megakaryocytes reduces platelet-derived growth factor-BB in platelets.
Journal of atherosclerosis and thrombosis 20110101
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Peroxisome proliferator-activated receptor activators protect sebocytes from apoptosis: a new treatment modality for acne?
The British journal of dermatology 20110101
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The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats.
BMC endocrine disorders 20110101
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Clofibrate relaxes the longitudinal smooth muscle of the mouse distal colon through calcium-mediated desensitisation of contractile machinery.
Pharmacology 20110101
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Two thiophenes compounds are partial peroxisome proliferator-activated receptor α/γ dual agonists.
Biological & pharmaceutical bulletin 20110101
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Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice.
Lipids in health and disease 20110101
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Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity.
Toxicology and applied pharmacology 20101215
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PPARalpha-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells.
Toxicological sciences : an official journal of the Society of Toxicology 20101201
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Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Toxicological sciences : an official journal of the Society of Toxicology 20101201
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Fenofibrate but not fenofibric acid inhibits 11beta-hydroxysteroid dehydrogenase 1 in C2C12 myotubes.
Molecular and cellular biochemistry 20101101
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Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 20101101
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Functionalization of fatty acid mimetics for solid-phase coupling and subsequent target identification.
Archiv der Pharmazie 20101101
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Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR.
Archives of toxicology 20101001
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PPARα contributes to colonic protection in mice with DSS-induced colitis.
International immunopharmacology 20101001
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Adiponectin-mediated heme oxygenase-1 induction protects against iron-induced liver injury via a PPARα dependent mechanism.
The American journal of pathology 20101001
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Effect of prenatal peroxisome proliferator-activated receptor alpha (PPARalpha) agonism on postnatal development.
Toxicology 20100930
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Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans.
Diabetologia 20100901
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Peroxisome proliferation activation receptor alpha modulation of Ca2+-regulated exocytosis via arachidonic acid in guinea-pig antral mucous cells.
Experimental physiology 20100801
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Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNFalpha/NF-kappaB signaling axis.
Leukemia 20100801
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Pravastatin attenuates carboplatin-induced nephrotoxicity in rodents via peroxisome proliferator-activated receptor alpha-regulated heme oxygenase-1.
Molecular pharmacology 20100701
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Evaluation of in vivo liver genotoxic potential of Wy-14,643 and piperonyl butoxide in rats subjected to two-week repeated oral administration.
Archives of toxicology 20100601
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Deciphering diseases and biological targets for environmental chemicals using toxicogenomics networks.
PLoS computational biology 20100501
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The effects of a PPARalpha agonist on myocardial damage in obese diabetic mice with heart failure.
International heart journal 20100501
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Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator.
Bioorganic & medicinal chemistry letters 20100415
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Validation of an in vitro screening test for predicting the tumor promoting potential of chemicals based on gene expression.
Toxicology in vitro : an international journal published in association with BIBRA 20100401
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Control of steroid 21-oic acid synthesis by peroxisome proliferator-activated receptor alpha and role of the hypothalamic-pituitary-adrenal axis.
The Journal of biological chemistry 20100305
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The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
The Journal of pharmacology and experimental therapeutics 20100301
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Impacts of different promoters on the mammalian one-hybrid assay for detecting nuclear receptor agonists.
Analytical and bioanalytical chemistry 20100301
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Short-term therapy with peroxisome proliferation-activator receptor-alpha agonist Wy-14,643 protects murine fatty liver against ischemia-reperfusion injury.
Hepatology (Baltimore, Md.) 20100301
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Enantiomer separation and indirect chromatographic absolute configuration prediction of chiral pirinixic acid derivatives: Limitations of polysaccharide-type chiral stationary phases in comparison to chiral anion-exchangers.
Journal of chromatography. A 20100212
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Design, synthesis, and docking studies of novel benzimidazoles for the treatment of metabolic syndrome.
Journal of medicinal chemistry 20100211
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Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse.
Carcinogenesis 20100201
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The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms.
Environmental health perspectives 20100201
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Induction of RIP-2 kinase by proinflammatory cytokines is mediated via NF-kappaB signaling pathways and involves a novel feed-forward regulatory mechanism.
Molecular and cellular biochemistry 20100101
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Glucans from the Caripia montagnei mushroom present anti-inflammatory activity.
International immunopharmacology 20100101
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Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.
Toxicological sciences : an official journal of the Society of Toxicology 20100101
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Iridoids from Fraxinus excelsior with adipocyte differentiation-inhibitory and PPARalpha activation activity.
Journal of natural products 20100101
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Analysis of the heat shock response in mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha).
BMC genomics 20100101
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Peroxisome proliferator-activated receptor alpha (PPARalpha) agonists induce constitutive androstane receptor (CAR) and cytochrome P450 2B in rat primary hepatocytes.
Drug metabolism and pharmacokinetics 20100101
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PPARα in Obesity: Sex Difference and Estrogen Involvement.
PPAR research 20100101
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WY-14 643, a selective PPAR{alpha} agonist, induces proinflammatory and proangiogenic responses in human ocular cells.
International journal of toxicology 20100101
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PRIC295, a Nuclear Receptor Coactivator, Identified from PPARα-Interacting Cofactor Complex.
PPAR research 20100101
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Gene Expression Profiling in Wild-Type and PPARα-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPARα-Independent Effects.
PPAR research 20100101
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Effects of the PPARα Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism.
PPAR research 20100101
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Regulation of Proteome Maintenance Gene Expression by Activators of Peroxisome Proliferator-Activated Receptor α.
PPAR research 20100101
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Role of the nuclear receptors HNF4 alpha, PPAR alpha, and LXRs in the TNF alpha-mediated inhibition of human apolipoprotein A-I gene expression in HepG2 cells.
Biochemistry 20091222
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The absence of a functional peroxisome proliferator-activated receptor-alpha gene in mice enhances motor sensitizing effects of morphine, but not cocaine.
Neuroscience 20091201
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Organic cation/carnitine transporter OCTN3 is present in astrocytes and is up-regulated by peroxisome proliferators-activator receptor agonist.
The international journal of biochemistry & cell biology 20091201
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Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver.
Molecular and cellular biology 20091201
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7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.
Journal of medicinal chemistry 20091112
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PPARalpha ligand WY14643 reduced acute rejection after rat lung transplantation with the upregulation of IL-4, IL-10 and TGFbeta mRNA expression.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20091101
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Studies on induction of lamotrigine metabolism in transgenic UGT1 mice.
Xenobiotica; the fate of foreign compounds in biological systems 20091101
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A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants.
Environmental health perspectives 20091101
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Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice.
Chemico-biological interactions 20091030
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New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function.
Journal of medicinal chemistry 20091022
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Chronic treatment with the peroxisome proliferator-activated receptor alpha agonist Wy-14,643 attenuates myocardial respiratory capacity and contractile function.
Molecular and cellular biochemistry 20091001
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Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells.
Biochimica et biophysica acta 20091001
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Synergistic acceleration of thyroid hormone degradation by phenobarbital and the PPAR alpha agonist WY14643 in rat hepatocytes.
Toxicology and applied pharmacology 20091001
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Regulation of CYP4A expression by bezafibrate in primary culture of rat and human hepatocytes: interspecies difference and influence of N-acetylcysteine.
Toxicology in vitro : an international journal published in association with BIBRA 20091001
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Interference of alpha-alkyl-substituted pirinixic acid derivatives with neutrophil functions and signalling pathways.
European journal of pharmacology 20091001
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PPARalpha ligands cause lymphocyte depletion and cell cycle block and this is associated with augmented TRB3 and reduced Cyclin B1 expression.
Molecular immunology 20091001
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Glucose deprivation, oxidative stress and peroxisome proliferator-activated receptor-alpha (PPARA) cause peroxisome proliferation in preimplantation mouse embryos.
Reproduction (Cambridge, England) 20090901
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Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner.
Hepatology (Baltimore, Md.) 20090901
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Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells.
Anticancer research 20090901
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Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor alpha activity.
Journal of lipid research 20090801
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Oleoylethanolamide, a natural ligand for PPAR-alpha, inhibits insulin receptor signalling in HTC rat hepatoma cells.
Biochimica et biophysica acta 20090801
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Differential hepatic effects of perfluorobutyrate mediated by mouse and human PPAR-alpha.
Toxicological sciences : an official journal of the Society of Toxicology 20090701
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Cyanide-induced death of dopaminergic cells is mediated by uncoupling protein-2 up-regulation and reduced Bcl-2 expression.
Toxicology and applied pharmacology 20090701
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PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 20090701
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Effects of WY-14643 on peroxisomal enzyme activity and hormone secretion in immortalized human trophoblast cells.
Biological & pharmaceutical bulletin 20090701
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Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species.
Reproductive toxicology (Elmsford, N.Y.) 20090601
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The IkappaBalpha gene is a peroxisome proliferator-activated receptor cardiac target gene.
The FEBS journal 20090601
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Differentiated CaCo-2 cells as an in-vitro model to evaluate de-novo apolipoprotein A-I production in the small intestine.
European journal of gastroenterology & hepatology 20090601
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Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy.
The Journal of toxicological sciences 20090601
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Peroxisome proliferator-activated receptor alpha activation induces unfavourable changes in fatty acid composition of myocardial phospholipids.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090601
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15-deoxy-Delta(12,14)-prostaglandin J(2) inhibits fibrogenic response in human hepatoma cells.
Toxicology letters 20090522
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Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase.
Archives of biochemistry and biophysics 20090501
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Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors.
Learning & memory (Cold Spring Harbor, N.Y.) 20090501
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Mechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis.
The Journal of biological chemistry 20090403
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Clinically relevant concentrations of di (2-ethylhexyl) phthalate (DEHP) uncouple cardiac syncytium.
Toxicology and applied pharmacology 20090401
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Cancer biomarker AKR1B10 and carbonyl metabolism.
Chemico-biological interactions 20090316
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Regulation of peroxisome proliferator-activated receptor-alpha by MDM2.
Toxicological sciences : an official journal of the Society of Toxicology 20090301
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Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver.
Toxicology and applied pharmacology 20090301
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PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway.
American journal of physiology. Heart and circulatory physiology 20090301
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Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1.
European journal of pharmacology 20090301
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Differential effects of in vivo PPAR alpha and gamma activation on fatty acid transport proteins expression and lipid content in rat liver.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090301
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Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification.
The Journal of investigative dermatology 20090201
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Rapid non-genomic regulation of Ca2+ signals and insulin secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans.
The Journal of endocrinology 20090201
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Optimization of an enzyme-linked immunosorbent assay to screen ligand of Peroxisome proliferator-activated receptor alpha.
Immunopharmacology and immunotoxicology 20090101
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Chronic, in vivo, PPARalpha activation prevents lipid overload in rat liver induced by high fat feeding.
Advances in medical sciences 20090101
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Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human.
PloS one 20090101
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Modulation of the hepatic fatty acid pool in peroxisomal 3-ketoacyl-CoA thiolase B-null mice exposed to the selective PPARalpha agonist Wy14,643.
Biochimie 20090101
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Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles.
PloS one 20090101
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Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Journal of medicinal chemistry 20081225
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Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design.
Journal of medicinal chemistry 20081225
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Effects of Wy14643 on hepatic ischemia reperfusion injury in rats.
World journal of gastroenterology 20081207
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PPARalpha activation and increased dietary lipid oppose thyroid hormone signaling and rescue impaired glucose-stimulated insulin secretion in hyperthyroidism.
American journal of physiology. Endocrinology and metabolism 20081201
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Synthesis and evaluation of a series of benzopyran derivatives as PPAR alpha/gamma agonists.
European journal of medicinal chemistry 20081101
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A PPARs cross-talk concertedly commits C6 glioma cells to oligodendrocytes and induces enzymes involved in myelin synthesis.
Journal of cellular physiology 20081101
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Peroxisome proliferator-activated receptor-alpha reduces inflammation and vascular leakage in a murine model of acute lung injury.
The European respiratory journal 20081101
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Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths.
Toxicological sciences : an official journal of the Society of Toxicology 20081101
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Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity.
Bioorganic & medicinal chemistry 20081101
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Inflammatory pathways are activated during cardiomyocyte hypertrophy and attenuated by peroxisome proliferator-activated receptors PPARalpha and PPARdelta.
The Journal of biological chemistry 20081024
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Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent.
Bioorganic & medicinal chemistry letters 20081015
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PPAR alpha, more than PPAR delta, mediates the hepatic and skeletal muscle alterations induced by the PPAR agonist GW0742.
Toxicological sciences : an official journal of the Society of Toxicology 20081001
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Effects of peroxisome proliferator-activated receptor alpha (PPARalpha) agonists on leucine-induced phosphorylation of translational targets in C2C12 cells.
Biochimica et biophysica acta 20081001
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Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.
Mutation research 20080926
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Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.
Journal of medicinal chemistry 20080911
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Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice.
Journal of hepatology 20080901
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A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats.
Toxicology 20080819
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Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.
Diabetes 20080801
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Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists.
Bioorganic & medicinal chemistry 20080801
-
Characterization of Madin-Darby bovine kidney cell line for peroxisome proliferator-activated receptors: temporal response and sensitivity to fatty acids.
Journal of dairy science 20080701
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The in vivo gene expression signature of oxidative stress.
Physiological genomics 20080612
-
Effect of peroxisome proliferator-activated receptor-alpha ligands in the interaction between adipocytes and macrophages in obese adipose tissue.
Obesity (Silver Spring, Md.) 20080601
-
Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha.
Biochimica et biophysica acta 20080601
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Gene profiling in the livers of wild-type and PPARalpha-null mice exposed to perfluorooctanoic acid.
Toxicologic pathology 20080601
-
Comparative hepatic effects of perfluorooctanoic acid and WY 14,643 in PPAR-alpha knockout and wild-type mice.
Toxicologic pathology 20080601
-
1Alpha,25-dihydroxyvitamin D3 attenuates cyanide-induced neurotoxicity by inhibiting uncoupling protein-2 up-regulation.
Journal of neuroscience research 20080501
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Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR.
Toxicological sciences : an official journal of the Society of Toxicology 20080501
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In vivo imaging reveals selective peroxisome proliferator activated receptor modulator activity of the synthetic ligand 3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid (MK-886).
Molecular pharmacology 20080501
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Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers.
European journal of pharmacology 20080428
-
PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators.
Toxicology 20080403
-
Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis.
The Journal of allergy and clinical immunology 20080401
-
Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine.
Biochimica et biophysica acta 20080401
-
Nuclear receptor agonists improve insulin responsiveness in cultured cardiomyocytes through enhanced signaling and preserved cytoskeletal architecture.
Endocrinology 20080301
-
Modulation of receptor phosphorylation contributes to activation of peroxisome proliferator activated receptor alpha by dehydroepiandrosterone and other peroxisome proliferators.
Molecular pharmacology 20080301
-
Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.
Bioorganic & medicinal chemistry 20080301
-
Alpha-alkyl substituted pirinixic acid derivatives as potent dual agonists of the peroxisome proliferator activated receptor alpha and gamma.
Archiv der Pharmazie 20080301
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Peroxisome proliferator-activated receptor alpha activation attenuated angiotensin type 1-mediated but enhanced angiotensin type 2-mediated hemodynamic effects to angiotensin II in the rat.
Journal of hypertension 20080301
-
Down-regulation of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase by polyunsaturated fatty acids in hepatocytes is not mediated by PPARalpha.
European journal of nutrition 20080301
-
The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha.
Toxicological sciences : an official journal of the Society of Toxicology 20080101
-
Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive oxygen species-dependent mechanism.
Stem cells (Dayton, Ohio) 20080101
-
Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies.
Environmental health perspectives 20080101
-
Placental implications of peroxisome proliferator-activated receptors in gestation and parturition.
PPAR research 20080101
-
Effect of synthetic dietary triglycerides: a novel research paradigm for nutrigenomics.
PloS one 20080101
-
PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression.
BMC genomics 20080101
-
Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response.
BMC genomics 20080101
-
Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders.
PPAR research 20080101
-
PPARalpha- and DEHP-Induced Cancers.
PPAR research 20080101
-
Analgesic properties of oleoylethanolamide (OEA) in visceral and inflammatory pain.
Pain 20071215
-
Time course investigation of PPARalpha- and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression.
Toxicology and applied pharmacology 20071215
-
Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver.
The Journal of biological chemistry 20071214
-
PPARalpha-dependent induction of the energy homeostasis-regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: potential role in starvation adaptation.
FEBS letters 20071211
-
Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha.
Mutation research 20071201
-
Inactivation of peroxisome proliferator-activated receptor isoforms alpha, beta/delta, and gamma mediate distinct facets of hypertrophic transformation of adult cardiac myocytes.
Pflugers Archiv : European journal of physiology 20071201
-
PPARalpha and PP2A are involved in the proapoptotic effect of conjugated linoleic acid on human hepatoma cell line SK-HEP-1.
International journal of cancer 20071201
-
PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages.
British journal of pharmacology 20071201
-
Hepatic PGC-1beta overexpression induces combined hyperlipidemia and modulates the response to PPARalpha activation.
Arteriosclerosis, thrombosis, and vascular biology 20071201
-
Peroxisome proliferator-activated receptor-alpha is required for the neurotrophic effect of oleic acid in neurons.
Journal of neurochemistry 20071101
-
Norepinephrine and rosiglitazone synergistically induce Elovl3 expression in brown adipocytes.
American journal of physiology. Endocrinology and metabolism 20071101
-
WY14,643, a PPARalpha ligand, attenuates expression of anti-glomerular basement membrane disease.
Clinical and experimental immunology 20071101
-
Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells.
European journal of pharmacology 20071001
-
Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
Circulation 20070918
-
Peroxisome proliferator-activated receptor alpha is involved in cardiomyocyte differentiation of murine embryonic stem cells in vitro.
Cell biology international 20070901
-
Cytotoxicity of peroxisome proliferator-activated receptor alpha and gamma agonists in renal proximal tubular cell lines.
Toxicology in vitro : an international journal published in association with BIBRA 20070901
-
The putative tumor suppressor Tsc-22 is downregulated early in chemically induced hepatocarcinogenesis and may be a suppressor of Gadd45b.
Toxicological sciences : an official journal of the Society of Toxicology 20070901
-
Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation.
Molecular endocrinology (Baltimore, Md.) 20070901
-
Different mechanisms of modulation of gap junction communication by non-genotoxic carcinogens in rat liver in vivo.
Toxicology 20070816
-
Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPARalpha activation and oxidative stress.
Toxicology and applied pharmacology 20070815
-
WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase.
Toxicological sciences : an official journal of the Society of Toxicology 20070801
-
The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter.
Journal of lipid research 20070801
-
A role of liver fatty acid-binding protein in cisplatin-induced acute renal failure.
Kidney international 20070801
-
Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists.
Bioorganic & medicinal chemistry letters 20070801
-
Activation of PPARdelta inhibits cardiac fibroblast proliferation and the transdifferentiation into myofibroblasts.
Cardiovascular research 20070801
-
Genome-wide analysis of PPARalpha activation in murine small intestine.
Physiological genomics 20070718
-
Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha.
Drug metabolism and disposition: the biological fate of chemicals 20070701
-
Quinoline-based derivatives of pirinixic acid as dual PPAR alpha/gamma agonists.
Archiv der Pharmazie 20070701
-
Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis.
The Journal of biological chemistry 20070615
-
Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.
European journal of pharmacology 20070601
-
PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes.
Diabetes 20070601
-
Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors.
Arteriosclerosis, thrombosis, and vascular biology 20070601
-
The peroxisome proliferator WY-14,643 promotes hepatocarcinogenesis caused by endogenously generated oxidative DNA base modifications in repair-deficient Csbm/m/Ogg1-/- mice.
Cancer research 20070601
-
The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.
Journal of hepatology 20070501
-
Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors.
Cellular and molecular life sciences : CMLS 20070501
-
Beyond lipids, pharmacological PPARalpha activation has important effects on amino acid metabolism as studied in the rat.
American journal of physiology. Endocrinology and metabolism 20070401
-
Synthesis and evaluation of N-acetyl-L-tyrosine based compounds as PPARalpha selective activators.
European journal of medicinal chemistry 20070401
-
Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function.
Journal of immunology (Baltimore, Md. : 1950) 20070401
-
PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle.
Biochemical and biophysical research communications 20070323
-
Immunoselection and characterization of a human genomic PPAR binding fragment located within POTE genes.
Biochimie 20070301
-
Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation.
Drug metabolism and disposition: the biological fate of chemicals 20070301
-
Tetradecylselenoacetic acid, a PPAR ligand with antioxidant, antiinflammatory, and hypolipidemic properties.
Arteriosclerosis, thrombosis, and vascular biology 20070301
-
PPARalpha agonist induces the accumulation of ceramide in the heart of rats fed high-fat diet.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070301
-
Activation of PPARalpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2.
Biochemical pharmacology 20070215
-
Peroxisome proliferator-activated receptor alpha-independent effects of peroxisome proliferators on cysteinyl leukotriene production in mast cells.
European journal of pharmacology 20070205
-
The dominant negative thyroid hormone receptor beta-mutant {Delta}337T alters PPAR{alpha} signaling in heart.
American journal of physiology. Endocrinology and metabolism 20070201
-
Sustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-alpha, but not NADPH oxidase.
Free radical biology & medicine 20070201
-
Activation of peroxisome proliferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism.
The American journal of pathology 20070201
-
Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation.
Journal of medicinal chemistry 20070125
-
Metabolism of phytol to phytanic acid in the mouse, and the role of PPARalpha in its regulation.
Journal of lipid research 20070101
-
Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells.
Toxicology and applied pharmacology 20070101
-
Cardiovascular actions of the peroxisome proliferator-activated receptor-alpha (PPARalpha) agonist Wy14,643.
Cardiovascular drug reviews 20070101
-
In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma and quantitative analysis of in vivo induction pathway.
Toxicology and applied pharmacology 20061215
-
Wy-14,643 and fenofibrate inhibit mitochondrial respiration in isolated rat cardiac mitochondria.
Mitochondrion 20061201
-
Peroxisome proliferator-activated receptor-alpha and glucocorticoids interactively regulate insulin secretion during pregnancy.
Diabetes 20061201
-
Profiling of gene expression in rat liver and rat primary cultured hepatocytes treated with peroxisome proliferators.
The Journal of toxicological sciences 20061201
-
Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor alpha.
American journal of physiology. Gastrointestinal and liver physiology 20061101
-
Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver.
Hepatology (Baltimore, Md.) 20061101
-
Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha.
Molecular pharmacology 20061001
-
Peroxisome proliferator-activated receptor alpha activation during pregnancy severely impairs mammary lobuloalveolar development in mice.
Endocrinology 20061001
-
WY 14,643 inhibits human aldose reductase activity.
Journal of enzyme inhibition and medicinal chemistry 20061001
-
Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain.
Endocrinology 20060901
-
PPARalpha-mediated upregulation of uncoupling protein-2 switches cyanide-induced apoptosis to necrosis in primary cortical cells.
Toxicological sciences : an official journal of the Society of Toxicology 20060901
-
Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity.
Journal of lipid research 20060901
-
Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth.
Pharmacogenetics and genomics 20060901
-
Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators.
Shock (Augusta, Ga.) 20060901
-
Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity.
Environmental health perspectives 20060901
-
Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: effects of the PPAR-alpha agonist WY14643.
Free radical biology & medicine 20060815
-
Activation of peroxisome proliferator-activated receptor alpha enhances apoptosis in the mouse liver.
Toxicological sciences : an official journal of the Society of Toxicology 20060801
-
Agonists of the peroxisome proliferator-activated receptor alpha induce a fiber-type-selective transcriptional response in rat skeletal muscle.
Toxicological sciences : an official journal of the Society of Toxicology 20060801
-
[Influence and mechanism of peroxisome proliferation activated receptor-alpha expression induced by WY14643 in rat lung with acute lung injury].
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20060801
-
PPARalpha and PPARgamma regulation of liver and adipose proteins in obese and dyslipidemic rodents.
Journal of proteome research 20060801
-
Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist.
The Journal of biological chemistry 20060707
-
The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats.
British journal of pharmacology 20060701
-
Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast.
Toxicology letters 20060601
-
Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.
The Journal of clinical investigation 20060601
-
Differential effects of contraction and PPAR agonists on the expression of fatty acid transporters in rat skeletal muscle.
The Journal of physiology 20060515
-
Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis.
Carcinogenesis 20060501
-
Protection against myocardial ischaemia/reperfusion injury by PPAR-alpha activation is related to production of nitric oxide and endothelin-1.
Basic research in cardiology 20060501
-
PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver.
Journal of lipid research 20060501
-
Synthesis and anti-diabetic activity of (RS)-2-ethoxy-3-{4-[2-(4-trifluoro-methanesulfonyloxy-phenyl)-ethoxy]-phenyl}-propionic acid.
Acta pharmacologica Sinica 20060501
-
Inhibition of hepatocarcinogenesis by the deletion of the p50 subunit of NF-kappaB in mice administered the peroxisome proliferator Wy-14,643.
Toxicological sciences : an official journal of the Society of Toxicology 20060401
-
Fenofibrate activates AMPK and increases eNOS phosphorylation in HUVEC.
Biochemical and biophysical research communications 20060324
-
Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression.
Endocrinology 20060301
-
Effects of fatty acids on skeletal muscle cell differentiation in vitro.
The British journal of nutrition 20060301
-
Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways.
Biochemical pharmacology 20060227
-
PPARalpha activation increases triglyceride mass and adipose differentiation-related protein in hepatocytes.
Journal of lipid research 20060201
-
Ginsenoside Rf, a component of ginseng, regulates lipoprotein metabolism through peroxisome proliferator-activated receptor alpha.
Biochemical and biophysical research communications 20060106
-
Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha.
Toxicological sciences : an official journal of the Society of Toxicology 20060101
-
Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR.
Drug metabolism and disposition: the biological fate of chemicals 20060101
-
Gene expression profiles in rat liver slices exposed to hepatocarcinogenic enzyme inducers, peroxisome proliferators, and 17alpha-ethinylestradiol.
International journal of toxicology 20060101
-
Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists.
BMC bioinformatics 20060101
-
Hepatocellular proliferation in response to agonists of peroxisome proliferator-activated receptor alpha: a role for Kupffer cells?
Journal of carcinogenesis 20060101
-
PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism.
Biochemical and biophysical research communications 20051230
-
PPARalpha activation potentiates AhR-induced CYP1A1 expression.
Toxicology 20051215
-
Peroxisomal proliferation protects from beta-amyloid neurodegeneration.
The Journal of biological chemistry 20051209
-
Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination.
Diabetes 20051201
-
Plasma free fatty acids and peroxisome proliferator-activated receptor alpha in the control of myocardial uncoupling protein levels.
Diabetes 20051201
-
ROLE OF ENDOGENOUS AND EXOGENOUS LIGANDS FOR THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR alpha IN THE DEVELOPMENT OF BLEOMYCIN-INDUCED LUNG INJURY.
Shock (Augusta, Ga.) 20051201
-
The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes.
The Journal of biological chemistry 20051118
-
Statins and PPARalpha agonists induce myotoxicity in differentiated rat skeletal muscle cultures but do not exhibit synergy with co-treatment.
Toxicology and applied pharmacology 20051101
-
Synthesis of new carbo- and heterocyclic analogues of 8-HETE and evaluation of their activity towards the PPARs.
Bioorganic & medicinal chemistry letters 20051015
-
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
Clinical chemistry 20051001
-
Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity.
American journal of physiology. Regulatory, integrative and comparative physiology 20050901
-
A teleost in vitro reporter gene assay to screen for agonists of the peroxisome proliferator-activated receptors.
Environmental toxicology and chemistry 20050901
-
Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity.
Journal of medicinal chemistry 20050825
-
Comparison of the expression profiles induced by genotoxic and nongenotoxic carcinogens in rat liver.
Mutation research 20050804
-
Regulation of peroxisome proliferator-activated receptor alpha by protein kinase C.
Biochemistry 20050802
-
Anti-inflammatory effect of fibrate protects from cisplatin-induced ARF.
American journal of physiology. Renal physiology 20050801
-
Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells.
Endocrinology 20050801
-
Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia.
Journal of neuroscience research 20050801
-
A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver.
The Biochemical journal 20050715
-
Evaluation of cytochrome P450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells.
Life sciences 20050715
-
Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors.
The Journal of pharmacology and experimental therapeutics 20050701
-
Adiponectin receptor gene expression in human skeletal muscle cells is not regulated by fibrates and thiazolidinediones.
International journal of obesity (2005) 20050701
-
Peroxisome proliferator-activated receptor alpha and its response element are required but not sufficient for transcriptional activation of the mouse heart-type fatty acid binding protein gene.
The international journal of biochemistry & cell biology 20050701
-
A new retinoid-like compound that activates peroxisome proliferator-activated receptors and lowers blood glucose in diabetic mice.
Biological & pharmaceutical bulletin 20050701
-
Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats.
Neuropharmacology 20050601
-
Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition.
Cancer research 20050515
-
Peroxisome proliferator-activated receptor alpha physically interacts with CCAAT/enhancer binding protein (C/EBPbeta) to inhibit C/EBPbeta-responsive alpha1-acid glycoprotein gene expression.
Molecular endocrinology (Baltimore, Md.) 20050501
-
Conditional regulation of the human CYP4X1 and CYP4Z1 genes.
Archives of biochemistry and biophysics 20050415
-
Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor.
Molecular pharmacology 20050401
-
Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases.
Journal of lipid research 20050401
-
Future strategies in the treatment of acute renal failure: growth factors, stem cells, and other novel therapies.
Current opinion in pediatrics 20050401
-
Unique patterns of gene expression changes in liver after treatment of mice for 2 weeks with different known carcinogens and non-carcinogens.
Carcinogenesis 20050301
-
Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.
Archives of biochemistry and biophysics 20050201
-
Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists.
The Journal of biological chemistry 20050128
-
Activation of peroxisome proliferator-activated receptor alpha increases the expression and activity of microsomal triglyceride transfer protein in the liver.
The Journal of biological chemistry 20050114
-
Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis.
Carcinogenesis 20050101
-
The peroxisome proliferator-activated receptor alpha activator, Wy14,643, is anti-inflammatory in vivo.
Inflammopharmacology 20050101
-
Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.
Journal of biochemical and molecular toxicology 20050101
-
The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes.
The Journal of biological chemistry 20041210
-
Peroxisome proliferator-activated receptor alpha induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-alpha activation properties.
Circulation research 20041210
-
Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver.
Molecular pharmacology 20041201
-
Peroxisome proliferator-activated receptor alpha regulates B lymphocyte development via an indirect pathway in mice.
Biochemical pharmacology 20041201
-
PPARalpha ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats.
Biochemical and biophysical research communications 20041112
-
Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle.
American journal of physiology. Endocrinology and metabolism 20041101
-
alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers.
The American journal of pathology 20041101
-
Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites.
Gastroenterology 20041101
-
Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors.
The Journal of biological chemistry 20041029
-
Statin induction of liver fatty acid-binding protein (L-FABP) gene expression is peroxisome proliferator-activated receptor-alpha-dependent.
The Journal of biological chemistry 20041029
-
PPARalpha activators down-regulate CYP2C7, a retinoic acid and testosterone hydroxylase.
Toxicology 20041015
-
Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver.
Toxicology 20041015
-
Integrated genomic and proteomic analyses of gene expression in Mammalian cells.
Molecular & cellular proteomics : MCP 20041001
-
WY 14643, a potent exogenous PPAR-alpha ligand, reduces intestinal injury associated with splanchnic artery occlusion shock.
Shock (Augusta, Ga.) 20041001
-
Enhancement of insulin signaling through inhibition of tissue lipid accumulation by activation of peroxisome proliferator-activated receptor (PPAR) alpha in obese mice.
Medical science monitor : international medical journal of experimental and clinical research 20041001
-
17beta-hydroxysteroid dehydrogenase type 11 is a major peroxisome proliferator-activated receptor alpha-regulated gene in mouse intestine.
European journal of biochemistry 20041001
-
Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro.
The British journal of dermatology 20041001
-
Beneficial and deleterious effects of rosiglitazone on hypertension development in spontaneously hypertensive rats.
American journal of hypertension 20040901
-
PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.
Regulatory peptides 20040815
-
Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha.
Alcohol (Fayetteville, N.Y.) 20040801
-
Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons.
Journal of neuroscience research 20040715
-
Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators.
Bioorganic & medicinal chemistry letters 20040705
-
Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes.
Biochimica et biophysica acta 20040705
-
Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha).
The Journal of biological chemistry 20040702
-
Dissociation of oxidant production by peroxisome proliferator-activated receptor ligands from cell death in human cell lines.
Free radical biology & medicine 20040701
-
Protein profiling of mouse livers with peroxisome proliferator-activated receptor alpha activation.
Molecular and cellular biology 20040701
-
WY-14643 and 9- cis-retinoic acid induce IRS-2/PI 3-kinase signalling pathway and increase glucose transport in human skeletal muscle cells: differential effect in myotubes from healthy subjects and Type 2 diabetic patients.
Diabetologia 20040701
-
Different ways to regulate the PPARalpha stability.
Biochemical and biophysical research communications 20040625
-
Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver.
The Journal of biological chemistry 20040604
-
Coadministration of a liver X receptor agonist and a peroxisome proliferator activator receptor-alpha agonist in Mice: effects of nuclear receptor interplay on high-density lipoprotein and triglyceride metabolism in vivo.
The Journal of pharmacology and experimental therapeutics 20040601
-
Differential regulation of cytosolic and peroxisomal bile acid amidation by PPAR alpha activation favors the formation of unconjugated bile acids.
Journal of lipid research 20040601
-
Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha.
Cancer research 20040601
-
The human semaphorin 6B gene is down regulated by PPARs.
Genomics 20040601
-
Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases.
The Journal of biological chemistry 20040521
-
Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1.
The Journal of biological chemistry 20040521
-
Modulation of PPARalpha expression and inflammatory interleukin-6 production by chronic glucose increases monocyte/endothelial adhesion.
Arteriosclerosis, thrombosis, and vascular biology 20040501
-
Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice.
Hepatology (Baltimore, Md.) 20040501
-
Cardiovascular drugs inhibit MMP-9 activity from human THP-1 macrophages.
DNA and cell biology 20040501
-
Peroxisome proliferator-activated receptor-alpha regulates postischemic liver injury.
American journal of physiology. Gastrointestinal and liver physiology 20040401
-
Peroxisome proliferator-activated receptor alpha agonists increase nitric oxide synthase expression in vascular endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 20040401
-
Characterization of the species-specificity of peroxisome proliferators in rat and human hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 20040401
-
Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level.
The Biochemical journal 20040315
-
PPAR alpha ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity.
American journal of physiology. Renal physiology 20040301
-
Reduction of palmitate-induced cardiac apoptosis by fenofibrate.
Molecular and cellular biochemistry 20040301
-
PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation.
Circulation research 20040220
-
Catalase transgenic mice: characterization and sensitivity to oxidative stress.
Archives of biochemistry and biophysics 20040215
-
Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators.
Cancer research 20040201
-
Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells.
Immunity 20040201
-
15-Deoxy-delta(12,14)-prostaglandin J2 inhibits the IL-1beta-induced expression of granulocyte-macrophage colony-stimulating factor in BEAS-2B bronchial epithelial cells.
The Tohoku journal of experimental medicine 20040201
-
Hepatocarcinogenesis by peroxisome proliferators.
The Journal of toxicological sciences 20040201
-
Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR.
Biochemical and biophysical research communications 20040130
-
Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes.
Biochemical and biophysical research communications 20040109
-
Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth.
Biochemical pharmacology 20040101
-
Relationship between PPARalpha activation and NO on proximal tubular Na+ transport in the rat.
BMC pharmacology 20040101
-
Peroxisome proliferator-activated receptor agonists inhibit interleukin-1beta-mediated nitric oxide production in cultured lacrimal gland acinar cells.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201
-
Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice.
Journal of lipid research 20031101
-
Induction of plasminogen activator inhibitor I by the PPARalpha ligand, Wy-14,643, is dependent on ERK1/2 signaling pathway.
Thrombosis and haemostasis 20031001
-
WY-14,643-mediated promotion of hepatocarcinogenesis in connexin32-wild-type and connexin32-null mice.
Carcinogenesis 20030901
-
Assessment of hepatocytes and liver slices as in vitro test systems to predict in vivo gene expression.
Toxicological sciences : an official journal of the Society of Toxicology 20030901
-
Peroxisome proliferator activated receptor (PPAR)alpha agonists inhibit hypertrophy of neonatal rat cardiac myocytes.
Endocrinology 20030901
-
Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme.
The Journal of biological chemistry 20030829
-
Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice.
The Journal of biological chemistry 20030725
-
Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice.
American journal of physiology. Heart and circulatory physiology 20030701
-
Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.
Molecular endocrinology (Baltimore, Md.) 20030701
-
Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis.
Diabetes 20030701
-
Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice.
Hepatology (Baltimore, Md.) 20030701
-
Bezafibrate is a dual ligand for PPARalpha and PPARbeta: studies using null mice.
Biochimica et biophysica acta 20030610
-
Identification of hepatic transcriptional changes in insulin-resistant rats treated with peroxisome proliferator activated receptor-alpha agonists.
Journal of molecular endocrinology 20030601
-
Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators.
The Journal of biological chemistry 20030516
-
Increased expression of the lipocalin 24p3 as an apoptotic mechanism for MK886.
The Biochemical journal 20030515
-
Activation-induced PPARgamma expression sensitizes primary human T cells toward apoptosis.
Journal of leukocyte biology 20030501
-
Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643.
Toxicology and applied pharmacology 20030501
-
Acute (24 h) activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) reverses high-fat feeding-induced insulin hypersecretion in vivo and in perifused pancreatic islets.
The Journal of endocrinology 20030501
-
Dysregulation of DNA repair pathways in a transforming growth factor alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis.
Laboratory investigation; a journal of technical methods and pathology 20030501
-
Hepatic protein expression of lean mice and obese diabetic mice treated with peroxisome proliferator-activated receptor activators.
Proteomics 20030401
-
Protein expression changes in the Sprague Dawley rat liver proteome following administration of peroxisome proliferator activated receptor alpha and gamma ligands.
Proteomics 20030401
-
Peroxisome proliferator-activated receptor alpha is involved in the regulation of lipid metabolism by ginseng.
British journal of pharmacology 20030401
-
Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643.
Carcinogenesis 20030401
-
Activation of peroxisome proliferator-activated receptors alpha and gamma1 inhibits human smooth muscle cell proliferation.
Molecular and cellular biochemistry 20030401
-
15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism.
Biochemical and biophysical research communications 20030307
-
PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly.
American journal of physiology. Endocrinology and metabolism 20030301
-
Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy.
Journal of immunology (Baltimore, Md. : 1950) 20030301
-
PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway.
Journal of the American Society of Nephrology : JASN 20030301
-
Age-dependent effects of nongenotoxic hepatocarcinogens on liver apoptosis in vivo.
Mechanisms of ageing and development 20030301
-
Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages.
Circulation research 20030207
-
Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice.
The Biochemical journal 20030201
-
Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone.
The Biochemical journal 20030201
-
Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes.
Journal of dermatological science 20030201
-
Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes.
The Journal of biological chemistry 20030103
-
Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone.
Archives of biochemistry and biophysics 20030101
-
Peroxisome proliferator-activated receptor-alpha activation during pregnancy attenuates glucose-stimulated insulin hypersecretion in vivo by increasing insulin sensitivity, without impairing pregnancy-induced increases in beta-cell glucose sensing and responsiveness.
Endocrinology 20030101
-
Delayed induction of delta-6 and delta-5 desaturases by a peroxisome proliferator.
Biochemical and biophysical research communications 20021220
-
WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 20021215
-
Non-genotoxic carcinogens: early effects on gap junctions, cell proliferation and apoptosis in the rat.
Toxicology 20021202
-
Peroxisome proliferator-activated receptor activators inhibit oxidized low-density lipoprotein-induced endothelin-1 secretion in endothelial cells.
Journal of cardiovascular pharmacology 20021201
-
Agonists of peroxisome-proliferator activated receptor-alpha (clofibrate and WY14643) reduce renal ischemia/reperfusion injury in the rat.
Medical science monitor : international medical journal of experimental and clinical research 20021201
-
Hepatic expression of polymerase beta, Ref-1, PCNA, and Bax in WY 14,643-exposed rats and hamsters.
Experimental and molecular pathology 20021201
-
PPAR-alpha ligands inhibit H2O2-mediated activation of transforming growth factor-beta1 in human mesangial cells.
Antioxidants & redox signaling 20021201
-
PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4.
Circulation research 20021129
-
Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms.
Archives of biochemistry and biophysics 20021115
-
AZ 242, a novel PPARalpha/gamma agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats.
Journal of lipid research 20021101
-
A metabolic switching hypothesis for the first step in the hypolipidemic effects of fibrates.
Biological & pharmaceutical bulletin 20021101
-
PPAR alpha stimulates the rat gastrin-producing cell.
Molecular and cellular endocrinology 20020930
-
Peroxisome proliferator-activated receptor ligands negatively regulate the expression of the high-affinity IgE receptor Fc epsilon RI in human basophilic KU812 cells.
Biochemical and biophysical research communications 20020920
-
Inhibition of cytokine-induced matrix metalloproteinase 9 expression by peroxisome proliferator-activated receptor alpha agonists is indirect and due to a NO-mediated reduction of mRNA stability.
The Journal of biological chemistry 20020906
-
PPAR agonists amplify iNOS expression while inhibiting NF-kappaB: implications for mesangial cell activation by cytokines.
Journal of the American Society of Nephrology : JASN 20020901
-
Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices.
Xenobiotica; the fate of foreign compounds in biological systems 20020901
-
Effects of the rat hepatic peroxisome proliferator, Wyeth 14,643, on the lactating goat.
Drug and chemical toxicology 20020801
-
Peroxisome proliferator-activated receptor alpha in the human breast cancer cell lines MCF-7 and MDA-MB-231.
Molecular carcinogenesis 20020801
-
Interactions of fluorochemicals with rat liver fatty acid-binding protein.
Toxicology 20020715
-
WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice.
The Journal of biological chemistry 20020705
-
Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020701
-
Ligands of the peroxisome proliferator-activated receptor-PPAR-a reduce myocardial infarct size.
Medical science monitor : international medical journal of experimental and clinical research 20020701
-
Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts.
Toxicology and applied pharmacology 20020701
-
Advantages of glutamate dehydrogenase as a blood biomarker of acute hepatic injury in rats.
Laboratory animals 20020701
-
Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48.
The Journal of biological chemistry 20020621
-
Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2.
Brain research 20020621
-
Gene expression analysis reveals chemical-specific profiles.
Toxicological sciences : an official journal of the Society of Toxicology 20020601
-
Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma.
Journal of neurochemistry 20020601
-
Peroxisome proliferator-activated receptor agonists inhibit inflammatory edema and hyperalgesia.
Inflammation 20020601
-
PPAR activators inhibit endothelial cell migration by targeting Akt.
Biochemical and biophysical research communications 20020524
-
Involvement of the peroxisome proliferator-activated receptor alpha in the immunomodulation caused by peroxisome proliferators in mice.
Biochemical pharmacology 20020515
-
Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells.
Atherosclerosis 20020501
-
Selective inhibition of cyclooxygenase-2 expression by 15-deoxy-Delta(12,14)(12,14)-prostaglandin J(2) in activated human astrocytes, but not in human brain macrophages.
Journal of immunology (Baltimore, Md. : 1950) 20020501
-
Comparative effects of phthalate monoesters on gap junctional intercellular communication and peroxisome proliferation in rodent and primate hepatocytes.
Journal of toxicology and environmental health. Part A 20020426
-
PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis.
Circulation research 20020405
-
Peroxisome proliferators activate growth regulatory pathways largely via peroxisome proliferator-activated receptor alpha-independent mechanisms.
Cellular signalling 20020401
-
Mechanism for peroxisome proliferator-activated receptor-alpha activator-induced up-regulation of UCP2 mRNA in rodent hepatocytes.
The Journal of biological chemistry 20020315
-
Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors.
Journal of immunology (Baltimore, Md. : 1950) 20020315
-
Potentiation of TNF-alpha-stimulated group IIA phospholipase A(2) expression by peroxisome proliferator-activated receptor alpha activators in rat mesangial cells.
Journal of the American Society of Nephrology : JASN 20020301
-
Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.
Journal of medicinal chemistry 20020214
-
The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020201
-
Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin.
Diabetes 20020201
-
Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism.
Arthritis and rheumatism 20020201
-
Characterization of the adipose tissue atrophy induced by peroxisome proliferators in mice.
Lipids 20020201
-
Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator- activated receptor alpha agonists.
Biochemical and biophysical research communications 20020125
-
PPARalpha and PPARdelta activators inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells.
European journal of pharmacology 20020125
-
Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism.
The Journal of biological chemistry 20020111
-
Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models.
The Journal of investigative dermatology 20020101
-
Effect of peroxisome proliferators on the methylation and protein level of the c-myc protooncogene in B6C3F1 mice liver.
Journal of biochemical and molecular toxicology 20020101
-
Profiling of acyl-CoA oxidase-deficient and peroxisome proliferator Wy14,643-treated mouse liver protein by surface-enhanced laser desorption/ionization ProteinChip Biology System.
Gene expression 20020101
-
The transcription of the peroxisome proliferator-activated receptor alpha gene is regulated by protein kinase C.
Toxicology letters 20011215
-
Antagonism of the actions of peroxisome proliferator-activated receptor-alpha by bile acids.
The Journal of biological chemistry 20011214
-
Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion.
Diabetes 20011201
-
Peroxisome proliferator-activated receptor alpha (PPAR alpha) agonist, WY-14,643, increased transcription of myosin light chain-2 in cardiomyocytes.
The Journal of toxicological sciences 20011201
-
Activators of peroxisome proliferator-activated receptors protect human skin from ultraviolet-B-light-induced inflammation.
The Journal of investigative dermatology 20011201
-
Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart.
The Journal of biological chemistry 20011130
-
Human peroxisome proliferator-activated receptor alpha (PPARalpha) supports the induction of peroxisome proliferation in PPARalpha-deficient mouse liver.
The Journal of biological chemistry 20011109
-
Hepatocellular proliferation in response to a peroxisome proliferator does not require TNFalpha signaling.
Carcinogenesis 20011101
-
Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression.
Arteriosclerosis, thrombosis, and vascular biology 20011101
-
Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development.
Molecular genetics and metabolism 20011101
-
Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines.
The Journal of biological chemistry 20011019
-
Stabilization of peroxisome proliferator-activated receptor alpha by the ligand.
Biochemical and biophysical research communications 20011019
-
Activation of the peroxisome proliferator-activated receptor-alpha enhances cell death in cultured cerebellar granule cells.
Journal of neuroscience research 20011015
-
Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha.
Biochemical and biophysical research communications 20010921
-
Comparison of the mutant frequencies and mutation spectra of three non-genotoxic carcinogens, oxazepam, phenobarbital, and Wyeth 14,643, at the lambdacII locus in Big Blue transgenic mice.
Biochemical pharmacology 20010915
-
Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta.
The Journal of biological chemistry 20010907
-
Phenobarbital, oxazepam and Wyeth 14,643 cause DNA damage as measured by the Comet assay.
Mutagenesis 20010901
-
Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice.
Biochemical and biophysical research communications 20010831
-
Effects of bezafibrate on beta-cell function of rat pancreatic islets.
European journal of pharmacology 20010831
-
Altered expression of the carboxylesterases ES-4 and ES-10 by peroxisome proliferator chemicals.
Toxicology 20010828
-
Regulation of p85alpha phosphatidylinositol-3-kinase expression by peroxisome proliferator-activated receptors (PPARs) in human muscle cells.
FEBS letters 20010803
-
(-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity.
Journal of medicinal chemistry 20010802
-
Peroxisome proliferator-activated receptor-alpha ligands inhibit cardiac lipoprotein lipase activity.
American journal of physiology. Heart and circulatory physiology 20010801
-
PPARalpha-dependent induction of liver microsomal esterification of estradiol and testosterone by a prototypical peroxisome proliferator.
Endocrinology 20010801
-
Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells.
The Journal of biological chemistry 20010727
-
Identification of a peroxisome-proliferator-activated-receptor response element in the apolipoprotein E gene control region.
The Biochemical journal 20010715
-
Inhibitors of arachidonic acid metabolism potentiate tumour necrosis factor-alpha-induced apoptosis in HL-60 cells.
European journal of pharmacology 20010713
-
Differential activation of hepatic NF-kappaB in rats and hamsters by the peroxisome proliferators Wy-14,643, gemfibrozil, and dibutyl phthalate.
Toxicological sciences : an official journal of the Society of Toxicology 20010701
-
Wy-14,643-induced hypomethylation of the c-myc gene in mouse liver.
Toxicological sciences : an official journal of the Society of Toxicology 20010701
-
Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells.
Experimental cell research 20010701
-
Cloning of the human cholesteryl ester hydrolase promoter: identification of functional peroxisomal proliferator-activated receptor responsive elements.
Biochemical and biophysical research communications 20010622
-
Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia.
Journal of immunology (Baltimore, Md. : 1950) 20010615
-
Evidence that reduction of hepatocyte growth factor (HGF) is not required for peroxisome proliferator-induced hepatocyte proliferation.
Carcinogenesis 20010601
-
The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor alpha-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal beta-oxidation enzymes acyl-CoA oxidase and hydratase-dehydrogenase.
Molecular and cellular endocrinology 20010515
-
Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells.
Toxicology and applied pharmacology 20010501
-
PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice.
The Journal of clinical investigation 20010415
-
Effects of peroxisome proliferators on antioxidant enzymes and antioxidant vitamins in rats and hamsters.
Toxicological sciences : an official journal of the Society of Toxicology 20010401
-
Differential regulation of expression of genes encoding uncoupling proteins 2 and 3 in brown adipose tissue during lactation in mice.
The Biochemical journal 20010401
-
The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis.
European journal of immunology 20010401
-
WY-14,643 and other agonists of the peroxisome proliferator-activated receptor reveal a new mode of action for salicylic acid in soybean disease resistance.
Planta 20010401
-
Peroxisome proliferators and fatty acids negatively regulate liver X receptor-mediated activity and sterol biosynthesis.
The Journal of steroid biochemistry and molecular biology 20010401
-
Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids.
American journal of physiology. Endocrinology and metabolism 20010301
-
Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats.
Toxicological sciences : an official journal of the Society of Toxicology 20010301
-
Tumor necrosis factor alpha is not required for WY14,643-induced cell proliferation.
Carcinogenesis 20010301
-
Peroxisome proliferators do not increase DNA synthesis in purified rat hepatocytes.
Carcinogenesis 20010301
-
Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010301
-
Effects of peroxisome proliferators on glutathione and glutathione-related enzymes in rats and hamsters.
Toxicology and applied pharmacology 20010215
-
Delayed activation of PPARgamma by LPS and IFN-gamma attenuates the oxidative burst in macrophages.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010201
-
PPARalpha agonists inhibit tissue factor expression in human monocytes and macrophages.
Circulation 20010116
-
PPARalpha activators inhibit tissue factor expression and activity in human monocytes.
Circulation 20010116
-
Fatty-acyl-CoA thioesters inhibit recruitment of steroid receptor co-activator 1 to alpha and gamma isoforms of peroxisome-proliferator-activated receptors by competing with agonists.
The Biochemical journal 20010115
-
Dexamethasone selectively inhibits WY14,643-induced cell proliferation and not peroxisome proliferation in mice.
Toxicology and applied pharmacology 20010115
-
Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates.
Biochimica et biophysica acta 20010115
-
Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell.
The Journal of biological chemistry 20010112
-
The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver.
The Journal of biological chemistry 20010105
-
Expression of the mRNA encoding truncated PPAR alpha does not correlate with hepatic insensitivity to peroxisome proliferators.
Molecular and cellular biochemistry 20010101
-
Therapeutic treatment of DMBA-induced mammary tumors with PPAR ligands.
Anticancer research 20010101
-
Unique renal tubule changes induced in rats and mice by the peroxisome proliferators 2,4-dichlorophenoxyacetic acid (2,4-D) and WY-14643.
Toxicologic pathology 20010101
-
Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis.
Gene expression 20010101
-
15-Deoxy-Delta(12,14)-prostaglandin J(2) facilitates thyroglobulin production by cultured human thyrocytes.
American journal of physiology. Cell physiology 20001201
-
Down-regulation of uncoupling protein-3 and -2 by thiazolidinediones in C2C12 myotubes.
FEBS letters 20001027
-
Keratinocyte differentiation in hyperproliferative epidermis: topical application of PPARalpha activators restores tissue homeostasis.
The Journal of investigative dermatology 20000901
-
Peroxisome proliferator-activated receptor alpha (PPARalpha) activators, bezafibrate and Wy-14,643, increase uncoupling protein-3 mRNA levels without modifying the mitochondrial membrane potential in primary culture of rat preadipocytes.
Archives of biochemistry and biophysics 20000815
-
Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene.
Diabetes 20000701
-
Evidence against the peroxisome proliferator-activated receptor alpha (PPARalpha) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription.
Journal of lipid research 20000501
-
The PPARs: from orphan receptors to drug discovery.
Journal of medicinal chemistry 20000224
-
The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes.
Cell biology and toxicology 20000101
-
trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals.
Toxicology and applied pharmacology 19991201
-
PPARalpha activation by Wy 14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARgamma-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes.
Biochemical and biophysical research communications 19991022
-
Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice.
Carcinogenesis 19990801
-
Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha.
Biochemical and biophysical research communications 19990714
-
Rosiglitazone (BRL49653), a PPARgamma-selective agonist, causes peroxisome proliferator-like liver effects in obese mice.
Journal of lipid research 19990701
-
Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth.
Diabetes 19990601
-
Effects of fibrate compounds on expression of plasminogen activator inhibitor-1 by cultured endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 19990601
-
A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats.
Diabetes 19981201
-
Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha.
Thrombosis and haemostasis 19981201
-
Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids.
Environmental health perspectives 19980801
-
Dietary glycine prevents increases in hepatocyte proliferation caused by the peroxisome proliferator WY-14,643.
Chemical research in toxicology 19971001
-
PPAR alpha structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents.
Biological chemistry 19970701
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Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs.
The Journal of biological chemistry 19970207
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Induction of cyclooxygenase-2 expression by peroxisome proliferators and non-tetradecanoylphorbol 12,13-myristate-type tumor promoters in immortalized mouse liver cells.
The Journal of biological chemistry 19970207
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Peroxisome proliferators alter the expression of estrogen-metabolizing enzymes.
Biochimie 19970101
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Molecular profiling of non-genotoxic hepatocarcinogenesis using differential display reverse transcription-polymerase chain reaction (ddRT-PCR).
European journal of drug metabolism and pharmacokinetics 19970101
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The PPARalpha-leukotriene B4 pathway to inflammation control.
Nature 19961107
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Growth regulation by peroxisome proliferators: opposing activities in early and late G1.
Cancer research 19960715
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Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate.
Molecular pharmacology 19960701
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A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation.
Cell 19951201
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Gemfibrozil-induced peroxisome proliferation and hepatomegaly in male F344 rats.
Cancer letters 19951106
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Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element.
The Journal of biological chemistry 19941209
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Initiator-specific promotion of hepatocarcinogenesis by WY-14,643 and clofibrate.
Carcinogenesis 19940801
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Proliferating cell nuclear antigen: a marker for hepatocellular proliferation in rodents.
Environmental health perspectives 19931201
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cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor.
Biochemistry 19930601
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Loss of peroxisomal enzyme expression in preneoplastic and neoplastic lesions induced by peroxisome proliferators in rat livers.
Carcinogenesis 19920201
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Peroxisome proliferator-induced alterations in the expression and modification of rat hepatocyte plasma membrane proteins.
Cancer research 19900201
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Reversible alteration in the expression of the gap junctional protein connexin 32 during tumor promotion in rat liver and its role during cell proliferation.
Cancer communications 19900101
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Lack of expression of glutathione-S-transferase P, gamma-glutamyl transpeptidase, and alpha-fetoprotein messenger RNAs in liver tumors induced by peroxisome proliferators.
Cancer research 19880901
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Peroxisome proliferation in primary cultures of rat hepatocytes.
Toxicology and applied pharmacology 19830101
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Enhancement by Wy-14,643, a hepatic peroxisome proliferator, of diethylnitrosamine-initiated hepatic tumorigenesis in the rat.
British journal of cancer 19781001