50924-49-7 | Mizoribine

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$9.00	$6.00
5mg	98%	in stock	$19.00	$14.00
10mg	98%	in stock	$24.00	$17.00
25mg	98%(HPLC)	in stock	$42.00	$30.00
50mg	98%	in stock	$43.00	$30.00
100mg	98%(HPLC)	in stock	$74.00	$52.00
250mg	98%(HPLC)	in stock	$153.00	$107.00
1g	98%	in stock	$416.00	$291.00

Description

• Catalog Number: AI51441
• Chemical Name: Mizoribine
• CAS Number: 50924-49-7
• Molecular Formula: C9H13N3O6
• Molecular Weight: 259.2160
• MDL Number: MFCD30181862
• SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc(c1O)C(=O)N

Computed Properties

• Complexity: 329
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 5
• Rotatable Bond Count: 3
• XLogP3: -1.9

Literature

• Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay.

  Archives of toxicology 20180601

• Efficacy and safety of multitarget therapy with mizoribine and tacrolimus for systemic lupus erythematosus with or without active nephritis.

  Lupus 20121101

• Population pharmacokinetics of mizoribine in pediatric recipients of renal transplantation.

  Clinical and experimental nephrology 20121001

• Mizoribine, tacrolimus, and corticosteroid combination therapy successfully induces remission in patients with lupus nephritis.

  Clinical and experimental nephrology 20121001

• Effect of single-dose oral mizoribine pulse therapy twice per week for frequently relapsing steroid-dependent nephrotic syndrome.

  Clinical nephrology 20120701

• Childhood nephrotic syndrome--current and future therapies.

  Nature reviews. Nephrology 20120612

• Pharmacokinetics of mizoribine in adult living donor liver transplantation.

  Transplantation proceedings 20120601

• Addition of mizoribine to the prednisolone plus tacrolimus treatment regimen in a patient with lupus flare.

  Rheumatology international 20120401

• GSTT1 gene abnormality in minimal change nephrotic syndrome with elevated serum immunoglobulin E.

  Clinical nephrology 20120401

• Mizoribine--an inosine monophosphate dehydrogenase inhibitor--acts synergistically with cyclosporine A in prolonging survival of murine islet cell and heart transplants across major histocompatibility barrier.

  Transplant immunology 20120301

• Final height in a prospective trial of late steroid withdrawal after pediatric renal transplantation treated with cyclosporine and mizoribine.

  Pediatric transplantation 20120201

• Developmental disruption of the serotonin system alters circadian rhythms.

  Physiology & behavior 20120118

• The efficacy and safety of high-dose mizoribine in ABO-incompatible kidney transplantation using anti-CD20 and anti-CD25 antibody without splenectomy treatment.

  Transplantation proceedings 20120101

• Excellent results with high-dose mizoribine combined with cyclosporine, corticosteroid, and basiliximab in renal transplant recipients: multicenter study in Japan.

  Transplantation proceedings 20120101

• Experiences of high-dose mizoribine as antimetabolite immunosuppressants for kidney transplantation.

  Transplantation proceedings 20120101

• Mizoribine suppresses proliferation of rat glomerular epithelial cells in culture and inhibits increase of monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 stimulated by thrombin.

  Biological & pharmaceutical bulletin 20120101

• A case of acute kidney injury with marked hyperuricemia during mizoribine administration.

  Internal medicine (Tokyo, Japan) 20120101

• Mizoribine as sole immunosuppressive agent in islet xenotransplantation models: a candidate immunosuppressant causing no adverse effects on islets.

  Cell transplantation 20120101

• Mizoribine treatment for antihistamine-resistant chronic autoimmune urticaria.

  Dermatologic therapy 20120101

• Therapeutic effect of mizoribine on pemphigus vulgaris and pemphigus foliaceus.

  Dermatologic therapy 20120101

• Chronopharmacology of mizoribine in collagen-induced arthritis rats.

  Journal of pharmacological sciences 20120101

• [Therapy in IgA nephropathy--when and how to do it].

  Orvosi hetilap 20111218

• Population pharmacokinetics of mizoribine in adult recipients of renal transplantation.

  Clinical and experimental nephrology 20111201

• Structures of Burkholderia thailandensis nucleoside kinase: implications for the catalytic mechanism and nucleoside selectivity.

  Acta crystallographica. Section D, Biological crystallography 20111101

• [Treatment of rheumatic diseases: current status and future prospective. Topics: II. Immunosuppressant/antirheumatic drugs; 5. Leflunomide and mizoribine].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20111010

• Successful use of mizoribine in a patient with sarcoidosis and cutaneous vasculitis.

  Acta dermato-venereologica 20110901

• Novel multidrug therapy for children with cyclosporine-resistant or -intolerant nephrotic syndrome.

  Pediatric nephrology (Berlin, Germany) 20110801

• Enzymatic assay method for measuring mizoribine levels in serum.

  Journal of bioscience and bioengineering 20110801

• Use of mizoribine in two patients with recalcitrant cutaneous polyarteritis nodosa.

  Journal of the American Academy of Dermatology 20110601

• Efficacy and safety of mizoribine combined with losartan in the treatment of IgA nephropathy: a multicenter, randomized, controlled study.

  The American journal of the medical sciences 20110501

• Unexpected occurrence of adrenal Cushing's syndrome in a patient with systemic lupus erythematosus.

  Hypertension research : official journal of the Japanese Society of Hypertension 20110501

• Methylprednisolone pulse plus mizoribine in children with Henoch-Schoenlein purpura nephritis.

  Clinical rheumatology 20110401

• Steroid treatment in patients with membranous nephropathy and hepatitis B virus surface antigenemia: a report of two cases.

  Clinical and experimental nephrology 20110401

• Therapeutic efficacy of mizoribine for discoid lupus erythematosus with normalized frequency of circulating T helper 17 cells.

  Clinical and experimental dermatology 20110401

• Single daily high-dose mizoribine therapy for children with steroid-dependent nephrotic syndrome prior to cyclosporine administration.

  Pediatric nephrology (Berlin, Germany) 20110301

• Modulation in concentrative nucleoside transporters-mediated intestinal absorption of mizoribine, an immunosuppressive agent, in lipopolysaccharide-treated rats.

  Die Pharmazie 20110301

• Methylprednisolone pulse therapy combined with mizoribine following tonsillectomy for immunoglobulin A nephropathy: clinical remission rate, steroid sparing effect, and maintenance of renal function.

  Clinical and experimental nephrology 20110201

• Disappearance of glomerular IgA deposits in childhood IgA nephropathy showing diffuse mesangial proliferation after 2 years of combination/prednisolone therapy.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110101

• Evaluation of limited sampling designs to estimate maximal concentration and area under the curve of mizoribine in pediatric patients with renal disease.

  Drug metabolism and pharmacokinetics 20110101

• [Two cases of rapidly progressive nephritic syndrome complicated with alcoholic liver cirrhosis].

  Nihon Jinzo Gakkai shi 20110101

• Cardiac AA amyloidosis in a patient with rheumatoid arthritis and systemic sclerosis: the therapeutic potential of biological reagents.

  Scandinavian journal of rheumatology 20110101

• [Efficacy and safety of combination therapy with mizoribine and methotrexate for rheumatoid arthritis resistant with methotrexate].

  Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20110101

• Effect of genetic polymorphisms of SLC28A1, ABCG2, and ABCC4 on bioavailability of mizoribine in healthy Japanese males.

  Drug metabolism and pharmacokinetics 20110101

• [Secondary membranous nephropathy: The topics of membranous lupus nephritis].

  Nihon Jinzo Gakkai shi 20110101

• Successful treatment of chronic lupus myocarditis with prednisolone and mizoribine.

  Modern rheumatology 20101201

• Low-dose steroid maintenance for renal transplant recipients.

  Transplantation proceedings 20101201

• Effects of probenecid on the pharmacokinetics of mizoribine and co-administration of the two drugs in patients with nephrotic syndrome.

  International journal of clinical pharmacology and therapeutics 20101101

• Mizoribine protects against bleomycin-induced lung injury.

  Modern rheumatology 20101001

• Modelling the effects of inhibitors of guanine nucleotide synthesis: implications for studies of cellular differentiation pathways.

  Biochemical Society transactions 20101001

• Efficacy of mizoribine for steroid-resistant membranoproliferative glomerulonephritis type III.

  Nephrology (Carlton, Vic.) 20101001

• Mizoribine attenuates renal injury and macrophage infiltration in patients with severe lupus nephritis.

  Clinical rheumatology 20100901

• Acute allograft renal failure with marked hyperuricemia developing during mizoribine administration: a case report with review of the literature.

  Transplantation proceedings 20100901

• A sensitive and practical LC-MS/MS method for the determination of mizoribine in human serum and its bioequivalence study on Chinese healthy volunteers.

  Yao xue xue bao = Acta pharmaceutica Sinica 20100901

• Increased intestinal absorption of mizoribine, an immunosuppressive agent, in cholestatic rats.

  Die Pharmazie 20100701

• Mizoribine therapy in a patient with lupus nephritis: the association between mizoribine concentration and peritoneal dialysis.

  Modern rheumatology 20100601

• Novel anticytomegalovirus activity of immunosuppressant mizoribine and its synergism with ganciclovir.

  The Journal of pharmacology and experimental therapeutics 20100601

• Combination therapy with steroids and mizoribine in juvenile SLE: a randomized controlled trial.

  Pediatric nephrology (Berlin, Germany) 20100501

• Impact of concentrative nucleoside transporter 1 gene polymorphism on oral bioavailability of mizoribine in stable kidney transplant recipients.

  Basic & clinical pharmacology & toxicology 20100401

• Mizoribine reduces serum KL-6 levels in ANCA-associated vasculitis.

  Clinical and experimental nephrology 20100401

• Study on intestinal absorption sites of mizoribine and ribavirin, substrates for concentrative nucleoside transporter(s), in rats.

  European journal of pharmacology 20100225

• Successful use of mizoribine to treat recurrent corticosteroid-resistant palpable purpura in a patient with henoch-schonlein purpura nephritis.

  Archives of dermatology 20100201

• Effect of mizoribine in children with inflammatory bowel disease.

  Pediatrics international : official journal of the Japan Pediatric Society 20100201

• New algorithm (KAWAKAMI algorithm) to diagnose primary cutaneous vasculitis.

  The Journal of dermatology 20100201

• Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat thy-1 mesangial proliferative glomerulonephritis.

  American journal of nephrology 20100101

• Combinational effect of low-dose oral corticosteroid and mizoribine for ulcerative colitis in a patient with systemic sclerosis.

  The Journal of dermatology 20100101

• The immunosuppressive drug mizoribine directly prevents podocyte injury in puromycin aminonucleoside nephrosis.

  Nephron. Experimental nephrology 20100101

• Treatment of Mikulicz's disease with mizoribine.

  Internal medicine (Tokyo, Japan) 20100101

• A case of Mikulicz's disease, IgG4-related plasmacytic syndrome, successfully treated by corticosteroid and mizoribine, followed by mizoribine alone.

  Internal medicine (Tokyo, Japan) 20100101

• A novel target of mizoribine inhibiting mesangial cell proliferation: S phase kinase-associated protein 2.

  American journal of nephrology 20100101

• Efficacy and safety of mizoribine by one single dose administration for patients with rheumatoid arthritis.

  Internal medicine (Tokyo, Japan) 20100101

• [Minimal change nephrotic syndrome].

  Nihon Jinzo Gakkai shi 20100101

• [Focal segmental glomerulosclerosis (FSGS)].

  Nihon Jinzo Gakkai shi 20100101

• [Immunosuppressive therapies for refractory nephrotic syndrome].

  Nihon Jinzo Gakkai shi 20100101

• Protective effects of Mizoribine on Cyclosporine A nephropathy in rats.

  Pediatric research 20091101

• Usefulness of initial histological features for stratifying Sjogren's syndrome responders to mizoribine therapy.

  Rheumatology (Oxford, England) 20091001

• Remission of refractory minimal change nephrotic syndrome after basiliximab therapy.

  Pediatric nephrology (Berlin, Germany) 20090701

• Iliopectineal bursitis associated with rapid destruction of a rheumatoid hip joint.

  Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20090701

• Efficacy of mizoribine pulse therapy in patients with rheumatoid arthritis who show a reduced or insufficient response to infliximab.

  Modern rheumatology 20090601

• Membrane transport mechanisms of mizoribine in the rat intestine and human epithelial LS180 cells.

  Biological & pharmaceutical bulletin 20090401

• Mizoribine may suppress bone erosion in patients with rheumatoid arthritis by inhibiting osteoclastogenesis.

  European journal of pharmacology 20090301

• Therapeutic effect of mizoribine on bullous pemphigoid associated with membranous nephropathy.

  Journal of the American Academy of Dermatology 20090301

• [Renal involvement in connective tissue diseases].

  Nihon rinsho. Japanese journal of clinical medicine 20090301

• [Immunosuppressants].

  Nihon rinsho. Japanese journal of clinical medicine 20090301

• Mizoribine for renal sarcoidosis: effective steroid tapering and prevention of recurrence.

  Pediatric nephrology (Berlin, Germany) 20090201

• Successful treatment of refractory polymyositis with the immunosuppressant mizoribine: case report.

  Clinical rheumatology 20090201

• A case report of steroid-resistant antineutrophil cytoplasmic antibody-related vasculitis successfully treated by mizoribine in a hemodialysis patient.

  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20090201

• [ANCA associated vasculitis and PRGN].

  Nihon Jinzo Gakkai shi 20090101

• Mizoribine suppresses the progression of experimental peritoneal fibrosis in a rat model.

  Nephron. Experimental nephrology 20090101

• Effects of low-dose mizoribine pulse therapy in combination with methotrexate in rheumatoid arthritis patients with an insufficient response to methotrexate.

  Modern rheumatology 20090101

• Mizoribine: a new approach in the treatment of renal disease.

  Clinical & developmental immunology 20090101

• A simple HPLC method for the quantification of mizoribine in human serum: pharmacokinetic applications.

  Biomedical chromatography : BMC 20081101

• Mizoribine for relapsed proteinuria in an adult IgA nephropathy patient.

  Clinical nephrology 20081101

• A novel enzymatic method for measuring mizoribine 5'-monophosphate levels in serum.

  Journal of bioscience and bioengineering 20081101

• Pharmacokinetic study of mizoribine in child-onset glomerulonephritis.

  Pediatrics international : official journal of the Japan Pediatric Society 20081001

• Hypocomplementemic urticarial vasculitis with Jaccoud's arthropathy and valvular heart disease: case report and review of the literature.

  Lupus 20080901

• Conversion from mycophenolate mofetil to mizoribine for patients with positive polyomavirus type BK in urine.

  Transplantation proceedings 20080901

• Oral mizoribine pulse therapy for steroid-dependent focal segmental glomerulosclerosis.

  Clinical nephrology 20080601

• Characterization of intestinal absorption of mizoribine mediated by concentrative nucleoside transporters in rats.

  European journal of pharmacology 20080531

• Combination therapy with mizoribine for severe childhood IgA nephropathy: a pilot study.

  Pediatric nephrology (Berlin, Germany) 20080501

• Use of mizoribine as a rescue drug for steroid-resistant pediatric IgA nephropathy.

  Pediatric nephrology (Berlin, Germany) 20080401

• Effect of oral mizoribine pulse therapy for frequently relapsing steroid-dependent nephrotic syndrome.

  Clinical nephrology 20080301

• Non-corticosteroid treatment for nephrotic syndrome in children.

  The Cochrane database of systematic reviews 20080123

• Mizoribine intermittent pulse protocol for induction therapy for systemic lupus erythematosus in children: an open-label pilot study with five newly diagnosed patients.

  Clinical rheumatology 20080101

• A case of lupus nephritis improved after appropriately adjusting the dosage of mizoribine.

  Modern rheumatology 20080101

• [Treatment of childhood IgA nephropathy].

  Nihon Jinzo Gakkai shi 20080101

• A sudden onset of diabetic ketoacidosis and acute pancreatitis after introduction of mizoribine therapy in a patient with rheumatoid arthritis.

  Modern rheumatology 20080101

• Mizoribine treatment of young patients with severe lupus nephritis: a clinicopathologic study by the tohoku pediatric study group.

  Nephron. Clinical practice 20080101

• Japanese experience of ABO-incompatible living kidney transplantation.

  Transplantation 20071227

• Towards a molecular genetic system for the pathogenic fungus Paracoccidioides brasiliensis.

  Fungal genetics and biology : FG & B 20071201

• Mechanism-of-action determination of GMP synthase inhibitors and target validation in Candida albicans and Aspergillus fumigatus.

  Chemistry & biology 20071001

• Mizoribine corrects defective nephrin biogenesis by restoring intracellular energy balance.

  Journal of the American Society of Nephrology : JASN 20070901

• Efficacy of steroid pulse, plasmapheresis, and mizoribine in a patient with focal segmental glomerulosclerosis.

  Pediatric nephrology (Berlin, Germany) 20070801

• Long-term intermittent pulse therapy with mizoribine attenuates histologic progression in young patients with severe lupus nephritis: report of two patients.

  Nephrology (Carlton, Vic.) 20070801

• Combination therapy of prednisolone and mizoribine improves cryoglobulinemic vasculitis with purpura and skin ulcers.

  Clinical rheumatology 20070701

• Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents.

  Bioorganic & medicinal chemistry letters 20070501

• Safety, tolerability and pharmacokinetics of higher-dose mizoribine in healthy male volunteers.

  British journal of clinical pharmacology 20070401

• Prophylactic treatment of antibody-mediated rejection with high-dose mizoribine and pharmacokinetic study.

  Transplant international : official journal of the European Society for Organ Transplantation 20070401

• Efficacy of single dose of oral mizoribine pulse therapy two times per week for frequently relapsing nephrotic syndrome.

  Journal of nephrology 20070101

• Mizoribine therapy for patients with lupus nephritis: the association between peak mizoribine concentration and clinical efficacy.

  Modern rheumatology 20070101

• Efficacy and safety of mizoribine for the treatment of Sjögren's syndrome: a multicenter open-label clinical trial.

  Modern rheumatology 20070101

• Population pharmacokinetics of higher-dose mizoribine in healthy male volunteers.

  Biological & pharmaceutical bulletin 20061201

• Mizoribine oral pulse therapy for a patient with polyarticular juvenile idiopathic arthritis.

  Pediatrics international : official journal of the Japan Pediatric Society 20061201

• Effects of mizoribine on MHC-restricted exogenous antigen presentation in dendritic cells.

  Archives of pharmacal research 20061201

• Comparison of tacrolimus and mizoribine in a randomized, double-blind controlled study in patients with rheumatoid arthritis.

  The Journal of rheumatology 20061101

• Changing mizoribine administration from three divided doses to one single dose induced remission of relapsed membranous nephropathy.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060801

• Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin.

  Antiviral research 20060801

• Combination effect of mycophenolate mofetil with mizoribine on cell proliferation assays and in a mouse heart transplantation model.

  Transplantation 20060727

• Long-term mizoribine intermittent pulse therapy for young patients with flare of lupus nephritis.

  Pediatric nephrology (Berlin, Germany) 20060701

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Mizoribine induces remission of relapsed ANCA-associated renal vasculitis.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060401

• High-dose mizoribine treatment for adolescents with systemic lupus erythematosus.

  Pediatrics international : official journal of the Japan Pediatric Society 20060401

• The nucleotide derivatives inosine and inosinic acid inhibit intestinal absorption of mizoribine in rats.

  European journal of pharmacology 20060215

• [Molecular action mechanisms of the therapeutic agents for kidney diseases: Immunosuppressants].

  Nihon rinsho. Japanese journal of clinical medicine 20060201

• Stevens-Johnson syndrome induced by mizoribine in a patient with systemic lupus erythematosus.

  Modern rheumatology 20060101

• [Beneficial and adverse effects of high-dosage MZR therapy in the management of children with frequently relapsing nephrotic syndrome].

  Nihon Jinzo Gakkai shi 20060101

• Acceptability and usefulness of mizoribine in the management of rheumatoid arthritis in methotrexate-refractory patients and elderly patients, based on analysis of data from a large-scale observational cohort study.

  Modern rheumatology 20060101

• Revival of effective and safe high-dose mizoribine for the kidney transplantation.

  Clinical transplantation 20060101

• High-dose mizoribine therapy for childhood-onset frequently relapsing steroid-dependent nephrotic syndrome with cyclosporin nephrotoxicity.

  Pediatric nephrology (Berlin, Germany) 20051201

• Induction therapy with low-dose intravenous cyclophosphamide, oral mizoribine, and steroids for severe lupus nephritis in children.

  Pediatric nephrology (Berlin, Germany) 20051001

• Oral mizoribine pulse therapy for patients with steroid-resistant and frequently relapsing steroid-dependent nephrotic syndrome.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20051001

• Mizoribine reduces renal injury and macrophage infiltration in non-insulin-dependent diabetic rats.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20050801

• Effects of long-term treatment with mizoribine in patients with proliferative lupus nephritis.

  Clinical nephrology 20050701

• Mizoribine decreases urinary protein excretion in two patients with IgA nephropathy.

  Clinical nephrology 20050701

• Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus.

  Antiviral research 20050601

• Implication of the peak serum level of mizoribine for control of the serum anti-dsDNA antibody titer in patients with lupus nephritis.

  Clinical nephrology 20050601

• Mizoribine inhibits hepatitis C virus RNA replication: effect of combination with interferon-alpha.

  Biochemical and biophysical research communications 20050513

• Immunosuppressive efficacy of mycophenolate mofetil when compared with azathioprine and mizoribine against peripheral lymphocytes from renal transplant recipients.

  Transplant international : official journal of the European Society for Organ Transplantation 20050501

• [Mizoribine].

  Nihon rinsho. Japanese journal of clinical medicine 20050501

• Potential value of high-dose mizoribine as rescue therapy for ongoing acute humoral rejection.

  Transplant international : official journal of the European Society for Organ Transplantation 20050401

• A prospective trial of steroid withdrawal after renal transplantation treated with cyclosporine and mizoribine in children: results obtained between 1990 and 2003.

  Pediatric transplantation 20050401

• Mizoribine-induced rhabdomyolysis in a rheumatoid arthritis patient receiving bezafibrate treatment.

  The American journal of the medical sciences 20050401

• The functional basis of mycophenolic acid resistance in Candida albicans IMP dehydrogenase.

  The Journal of biological chemistry 20050325

• Mizoribine in combination therapy with tacrolimus for living donor renal transplantation: analysis of a nationwide study in Japan.

  Transplantation proceedings 20050301

• Mizoribine oral pulse therapy for steroid-dependent nephrotic syndrome.

  Pediatric nephrology (Berlin, Germany) 20050101

• Mizoribine pulse therapy for a pediatric patient with steroid-resistant nephrotic syndrome.

  The Tohoku journal of experimental medicine 20050101

• Mizoribine-mediated apoptotic signaling pathway in human T-Cell line.

  Transplantation proceedings 20050101

• A simple determination of mizoribine in human plasma by liquid chromatography with UV detection.

  Journal of AOAC International 20050101

• [Treatment guidelines for the idiopathic nephrotic syndrome in children].

  Nihon Jinzo Gakkai shi 20050101

• Inhibition of bovine viral diarrhea virus (BVDV) by mizoribine: synergistic effect of combination with interferon-alpha.

  Antiviral research 20041201

• Mizoribine for the treatment of lupus nephritis in children and adolescents.

  Clinical nephrology 20041201

• Pharmacokinetic study of mizoribine in an adolescent with lupus nephritis.

  Pediatrics international : official journal of the Japan Pediatric Society 20041001

• [Immunosuppressive therapy for nephrotic syndrome and strategy for adverse side effects from that therapy].

  Nihon rinsho. Japanese journal of clinical medicine 20041001

• Efficacy of mizoribine in the treatment of systemic lupus erythematosus in children.

  Pediatrics international : official journal of the Japan Pediatric Society 20040801

• Mizoribine pulse therapy for patients with flares of lupus nephritis: a 1-year observation.

  Clinical nephrology 20040801

• Treatment with the purine synthesis inhibitor mizoribine for ANCA-associated renal vasculitis.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20040701

• [Angiotensin type 1 receptor blocker reduced proteinuria in patients of focal glomerular sclerosis].

  Nihon Jinzo Gakkai shi 20040701

• D-penicillamine-induced pemphigus successfully treated with combination therapy of mizoribine and prednisolone.

  The Journal of dermatological treatment 20040701

• A randomized open-label comparative study of conventional therapy versus mizoribine onlay therapy in patients with steroid-resistant nephrotic syndrome (postmarketing survey).

  Clinical and experimental nephrology 20040601

• [A case of rheumatoid arthritis/Sjogren's syndrome with acute renal failure due to hyperuricemia associated with mizoribine therapy].

  Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20040601

• Substitution of the conserved Arg-Tyr dyad selectively disrupts the hydrolysis phase of the IMP dehydrogenase reaction.

  Biochemistry 20040420

• Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target.

  Current medicinal chemistry 20040401

• A prospective trial of steroid withdrawal after renal transplantation in children: results obtained 1990 and 2002.

  Transplantation proceedings 20040301

• Efficacy of prednisolone and mizoribine therapy for diffuse IgA nephropathy.

  American journal of nephrology 20040101

• Allochronic overlapping malignancies after renal transplantation in a patient with p53 gene mutation: report of a case.

  Surgery today 20040101

• Efficacy of multidrug therapy combined with mizoribine in children with diffuse IgA nephropathy in comparison with multidrug therapy without mizoribine and with methylprednisolone pulse therapy.

  American journal of nephrology 20040101

• Mizoribine oral pulse therapy for patients with disease flare of lupus nephritis.

  Clinical nephrology 20031201

• Comparison of antiproteinuric effects of two different combination therapies in children with IgA nephropathy.

  Clinical and experimental nephrology 20031201

• Mizoribine oral pulse therapy for a patient with severe lupus nephritis.

  Pediatrics international : official journal of the Japan Pediatric Society 20030801

• The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase.

  Biochemistry 20030204

• [IMP dehydrogenase].

  Nihon rinsho. Japanese journal of clinical medicine 20030101

• Effect of conversion from cyclosporine A to mizoribine on transplant arteriosclerosis in rat aortic allograft models.

  Microsurgery 20030101

• Metabolic enzymes as targets for 14-3-3 proteins.

  Plant molecular biology 20021201

• Acute vascular and interstitial rejection following renal allograft transplantation in dogs.

  The Journal of veterinary medical science 20021201

• [Guidelines for the management of refractory nephrotic syndrome--from investigations between 1997 and 2001--research project team for progressive renal lesions in the Ministry of Health, Labor and Welfare, Japan].

  Nihon Jinzo Gakkai shi 20021201

• Inhibitors of the IMPDH enzyme as potential anti-bovine viral diarrhoea virus agents.

  Antiviral chemistry & chemotherapy 20021101

• [A case of acute renal failure with marked hyperuricemia developing during mizoribine administration].

  Nihon Jinzo Gakkai shi 20021001

• Synergistic effect of high-dose mizoribine and low-dose tacrolimus on renal allograft survival in nonhuman primates.

  Transplantation proceedings 20020801

• Reversible segmental stenotic lesion of subclavian artery in an 8-year-old girl: an atypical Takayasu's arteritis?

  Clinical rheumatology 20020801

• Effect of mizoribine on IL-6 release by peripheral blood mononuclear cells.

  Nephron 20020701

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Mizoribine: mode of action and effects in clinical use.

  Pediatrics international : official journal of the Japan Pediatric Society 20020401

• Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.

  Pediatrics international : official journal of the Japan Pediatric Society 20020401

• Nephrotic syndrome and mizoribine in children.

  Pediatrics international : official journal of the Japan Pediatric Society 20020401

• Mizoribine treatment for childhood IgA nephropathy.

  Pediatrics international : official journal of the Japan Pediatric Society 20020401

• Role of mizoribine in renal transplantation.

  Pediatrics international : official journal of the Japan Pediatric Society 20020401

• Identification of heat shock protein 60 as a molecular mediator of alpha 3 beta 1 integrin activation.

  Cancer research 20020301

• Potentiating effect of mizoribine on the anti-herpes virus activity of acyclovir.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101

• Mizoribine ameliorates the tubulointerstitial fibrosis of obstructive nephropathy.

  Nephron 20011001

• [Systemic lupus erythematosus presenting as a brainstem infarction and hemorrhage during treating retroperitoneal abscess: a case report].

  Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 20010701

• Effect of mizoribine on serum IgE concentration in patients with IgA nephropathy.

  Nephron 20010201

• The antiproliferative effect of mizoribine on rheumatoid synovial fibroblast mediated by induction of apoptosis.

  The Kobe journal of medical sciences 20010201

• Inosine-5'-monophosphate dehydrogenase is required for mitogenic competence of transformed pancreatic beta cells.

  Endocrinology 20010101

• The efficacy and safety of mizoribine in living donor kidney transplantation: a 24-week, open-label, prospective study (phase III clinical trial).

  Transplantation proceedings 20010101

• Long-term results of spousal renal donor transplants with donor-specific blood transfusions.

  Transplantation proceedings 20010101

• Dosing time-dependent pharmacological effects of anti-metabolites for rat cardiac graft.

  Research communications in molecular pathology and pharmacology 20010101

• Mizoribine in steroid-dependent nephrotic syndrome of childhood.

  Pediatric nephrology (Berlin, Germany) 19971001

• Mizoribine reduces urinary protein excretion in rats given puromycin aminonucleoside.

  American journal of nephrology 19960101

• [Comparison of the effects of various immunosuppressive drugs on subrenal capsule assay (SRC assay)].

  Hinyokika kiyo. Acta urologica Japonica 19900701

• [Suppressive effect of mizoribine on progression of bovine serum albumin nephritis in mice].

  Nihon Jinzo Gakkai shi 19870401