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Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans.
Diabetes 20150401
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Diminished adrenal sensitivity and ACTH efficacy in obese premenopausal women.
European journal of endocrinology 20121101
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Effects of acute and one-week fatty acid lowering on cardiac function and insulin sensitivity in relation with myocardial and muscle fat and adiponectin levels.
The Journal of clinical endocrinology and metabolism 20120901
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Role of β-adrenergic receptors in regulation of hepatic fat accumulation during aging.
The Journal of endocrinology 20120601
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Triglyceride, nonesterified fatty acids, and prediabetic neuropathy: role for oxidative-nitrosative stress.
Free radical biology & medicine 20120415
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Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms.
Arteriosclerosis, thrombosis, and vascular biology 20120301
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Pancreatic function, type 2 diabetes, and metabolism in aging.
International journal of endocrinology 20120101
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The effects of dietary intervention on HIV dyslipidaemia: a systematic review and meta-analysis.
PloS one 20120101
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Inhibition of lipolysis in Type 2 diabetes normalizes glucose disposal without change in muscle glycogen synthesis rates.
Clinical science (London, England : 1979) 20110801
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Insulin concerns and promises.
Diabetes care 20110601
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Palmitate-induced skeletal muscle insulin resistance does not require NF-κB activation.
Cellular and molecular life sciences : CMLS 20110401
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Acipimox reduces circulating levels of insulin and associated neutrophilic inflammation in metabolic syndrome.
American journal of physiology. Endocrinology and metabolism 20110401
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Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans.
Diabetes 20110301
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Acipimox during exercise points to an inhibitory feedback of GH on ghrelin secretion in bulimic and healthy women.
Regulatory peptides 20110225
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Effects of acute hyperglucagonemia on hepatic and intestinal lipoprotein production and clearance in healthy humans.
Diabetes 20110201
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Feedback modeling of non-esterified fatty acids in rats after nicotinic acid infusions.
Journal of pharmacokinetics and pharmacodynamics 20110201
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Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice.
Diabetes 20110201
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Diabetes 20110101
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Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes.
PloS one 20110101
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Rationale and design of a proof-of-concept trial investigating the effect of uninterrupted perioperative (par)enteral nutrition on amino acid profile, cardiomyocytes structure, and cardiac perfusion and metabolism of patients undergoing coronary artery bypass grafting.
Journal of cardiothoracic surgery 20110101
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Oleic acid induces smooth muscle foam cell formation and enhances atherosclerotic lesion development via CD36.
Lipids in health and disease 20110101
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Normal sweat secretion despite impaired growth hormone-insulin-like growth factor-I axis in obese subjects.
International journal of endocrinology 20110101
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Extended release niacin-laropiprant in patients with hypercholesterolemia or mixed dyslipidemias improves clinical parameters.
Clinical Medicine Insights. Cardiology 20110101
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Free fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolism.
PloS one 20110101
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A higher response of plasma neuropeptide Y, growth hormone, leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose tissue to Acipimox during exercise in patients with bulimia nervosa: single-blind, randomized, microdialysis study.
Nutrition & metabolism 20110101
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Transforming growth factor β receptor 1 is a new candidate prognostic biomarker after acute myocardial infarction.
BMC medical genomics 20110101
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RANTES/CCL5 and risk for coronary events: results from the MONICA/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies.
PloS one 20110101
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A study of pathogenesis of acanthosis nigricans and its clinical implications.
Indian journal of dermatology 20110101
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The intricate role of growth hormone in metabolism.
Frontiers in endocrinology 20110101
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Utilizing the second-meal effect in type 2 diabetes: practical use of a soya-yogurt snack.
Diabetes care 20101201
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Suppression of circulating free fatty acids with acipimox in chronic heart failure patients changes whole body metabolism but does not affect cardiac function.
American journal of physiology. Heart and circulatory physiology 20101001
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ECG-triggered 18F-fluorodeoxyglucose positron emission tomography imaging of the rat heart is dramatically enhanced by acipimox.
European journal of nuclear medicine and molecular imaging 20100801
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The diagnosis of GH deficiency in obese patients: a reappraisal with GHRH plus arginine testing after pharmacological blockade of lipolysis.
European journal of endocrinology 20100801
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Treatment of dyslipidemia in HIV-infected patients.
Expert opinion on pharmacotherapy 20100801
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Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009.
Diabetologia 20100701
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Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20100601
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Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysis.
Diabetes 20100601
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Insulin acutely inhibits intestinal lipoprotein secretion in humans in part by suppressing plasma free fatty acids.
Diabetes 20100301
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The decreased growth hormone response to growth hormone releasing hormone in obesity is associated to cardiometabolic risk factors.
Mediators of inflammation 20100101
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The eSS rat, a nonobese model of disordered glucose and lipid metabolism and fatty liver.
Diabetology & metabolic syndrome 20100101
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Pathogenesis of insulin resistance in skeletal muscle.
Journal of biomedicine & biotechnology 20100101
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The effect of ingested macronutrients on postprandial ghrelin response: a critical review of existing literature data.
International journal of peptides 20100101
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Individualized initiation of statin therapy determined by baseline LDL-C: Are you more likely to achieve goal LDL-C?
Risk management and healthcare policy 20100101
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Atherosclerosis. Supplements 20091229
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Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir.
Arteriosclerosis, thrombosis, and vascular biology 20091201
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The assessment of human regional drug absorption of free acid and sodium salt forms of acipimox, in healthy volunteers, to direct modified release formulation strategy.
Biopharmaceutics & drug disposition 20091201
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Skeletal muscle insulin resistance is the primary defect in type 2 diabetes.
Diabetes care 20091101
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Viewpoints on the way to the consensus session: where does insulin resistance start? The adipose tissue.
Diabetes care 20091101
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Effects of growth hormone and free fatty acids on insulin sensitivity in patients with type 1 diabetes.
The Journal of clinical endocrinology and metabolism 20090901
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Drug-induced liver disease: an 8-year study of patients from one gastroenterological department.
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The second-meal phenomenon in type 2 diabetes.
Diabetes care 20090701
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Free fatty acids inhibit growth hormone/signal transducer and activator of transcription-5 signaling in human muscle: a potential feedback mechanism.
The Journal of clinical endocrinology and metabolism 20090601
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Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.
Diabetes 20090401
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Effects of prolonged fasting and sustained lipolysis on insulin secretion and insulin sensitivity in normal subjects.
American journal of physiology. Endocrinology and metabolism 20090301
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Diabetes treatment.
Diabetes care 20090301
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Endoplasmic reticulum stress: another link between obesity and insulin resistance/inflammation?
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Extremely short duration high intensity interval training substantially improves insulin action in young healthy males.
BMC endocrine disorders 20090101
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Atrial natriuretic peptide induces postprandial lipid oxidation in humans.
Diabetes 20081201
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American College of Endocrinology Pre-Diabetes Consensus Conference: part three.
Diabetes care 20081201
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Changes in triglyceride levels over time and risk of type 2 diabetes in young men.
Diabetes care 20081001
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Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals.
Diabetes 20080901
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Short-term flexibility of myocardial triglycerides and diastolic function in patients with type 2 diabetes mellitus.
American journal of physiology. Endocrinology and metabolism 20080901
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The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans.
American journal of physiology. Endocrinology and metabolism 20080801
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Effects of statins on high-density lipoproteins: a potential contribution to cardiovascular benefit.
Cardiovascular drugs and therapy 20080801
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AAS, growth hormone, and insulin abuse: psychological and neuroendocrine effects.
Therapeutics and clinical risk management 20080601
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Glucose-insulin therapy, plasma substrate levels and cardiac recovery after cardiac ischemic events.
Cardiovascular drugs and therapy 20080401
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Orlistat in the prevention of diabetes in the obese patient.
Vascular health and risk management 20080401
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Dose-response effects of free fatty acids on amino acid metabolism and ureagenesis.
Acta physiologica (Oxford, England) 20080301
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Inflammation and lipid accumulation in xanthoma disseminatum: Therapeutic considerations.
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Butyrate ingestion improves hepatic glycogen storage in the re-fed rat.
BMC physiology 20080101
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International journal of obesity (2005) 20071101
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Intense [18F]FDG tongue uptake in a case of acipimox-related angio-oedema during FDG-PET myocardial viability study.
European journal of nuclear medicine and molecular imaging 20070801
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Inhibition of lipolysis stimulates peripheral glucose uptake but has no effect on endogenous glucose production in HIV lipodystrophy.
Diabetes 20070801
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Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes.
American journal of physiology. Endocrinology and metabolism 20070601
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Nicotinic acid receptor subtypes and their ligands.
Medicinal research reviews 20070501
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Dose-response effects of free fatty acids on glucose and lipid metabolism during somatostatin blockade of growth hormone and insulin in humans.
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Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b.
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Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects.
The Journal of clinical endocrinology and metabolism 20070401
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Growth hormone-induced insulin resistance is associated with increased intramyocellular triglyceride content but unaltered VLDL-triglyceride kinetics.
American journal of physiology. Endocrinology and metabolism 20070301
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Reduced plasma free fatty acid availability during exercise: effect on gene expression.
European journal of applied physiology 20070301
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Diabetes 20070301
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AIDS research and therapy 20070101
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Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists.
Journal of pharmacological and toxicological methods 20070101
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Combination therapy with acipimox enhances the effect of growth hormone treatment on linear body growth in the normal and small-for-gestational-age rat.
American journal of physiology. Endocrinology and metabolism 20061201
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Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure.
Circulation 20061114
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No low-fat diet for the failing heart?
Circulation 20061114
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Improved triglycerides and insulin sensitivity with 3 months of acipimox in human immunodeficiency virus-infected patients with hypertriglyceridemia.
The Journal of clinical endocrinology and metabolism 20061101
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Inhibition of lipolysis does not affect insulin sensitivity to glucose uptake in the mourning dove.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20060701
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Potential role of new therapies in modifying cardiovascular risk in overweight patients with metabolic risk factors.
Obesity (Silver Spring, Md.) 20060601
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Free fatty acids decrease circulating ghrelin concentrations in humans.
European journal of endocrinology 20060501
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Impact of diabetes mellitus on prediction of clinical outcome after coronary revascularization by 18F-FDG SPECT in patients with ischemic left ventricular dysfunction.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20060101
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[Effects of atorvastatin and acipimox on the lipid spectrum of blood plasma, endothelial function and a clinical course of unstable angina pectoris].
Terapevticheskii arkhiv 20060101
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Acute inhibition of lipolysis does not affect postprandial suppression of endogenous glucose production.
American journal of physiology. Endocrinology and metabolism 20051201
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Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients.
Diabetes 20051101
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Inhibition of adipose tissue lipolysis increases intramuscular lipid use in type 2 diabetic patients.
Diabetologia 20051001
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Effects of GH replacement therapy in adults on serum levels of leptin and ghrelin: the role of lipolysis.
European journal of endocrinology 20051001
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Inhibition of adipose tissue lipolysis increases intramuscular lipid and glycogen use in vivo in humans.
American journal of physiology. Endocrinology and metabolism 20050901
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[The pharmacokinetics and bioequivalence of acipimox sustained-release tablets after a single and multiple oral administration in healthy dogs].
Yao xue xue bao = Acta pharmaceutica Sinica 20050501
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The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle.
European journal of endocrinology 20050301
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Plasma adiponectin is modestly decreased during 24-hour insulin infusion but not after inhibition of lipolysis by Acipimox.
Scandinavian journal of clinical and laboratory investigation 20050101
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Enhanced circadian ACTH release in obese premenopausal women: reversal by short-term acipimox treatment.
American journal of physiology. Endocrinology and metabolism 20041101
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Free fatty acid levels modulate microvascular function: relevance for obesity-associated insulin resistance, hypertension, and microangiopathy.
Diabetes 20041101
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FFAs are not involved in regulation of gluconeogenesis and glycogenolysis in adults with uncomplicated P. falciparum malaria.
American journal of physiology. Endocrinology and metabolism 20041001
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Fat oxidation after acipimox-induced reduction in plasma nonesterified fatty acids during exercise at 0 degrees C and 20 degrees C.
Metabolism: clinical and experimental 20040901
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Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes.
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Anti-aging effects of anti-lipolytic drugs.
Experimental gerontology 20040701
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Free fatty acids increase hepatic glycogen content in obese males.
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Acute regulation of adiponectin by free fatty acids.
Metabolism: clinical and experimental 20040601
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Modulation of basal glucose metabolism and insulin sensitivity by growth hormone and free fatty acids during short-term fasting.
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Revista de medicina de la Universidad de Navarra 20040101
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Inhibition of lipolysis during acute GH exposure increases insulin sensitivity in previously untreated GH-deficient adults.
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Expert opinion on pharmacotherapy 20031101
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Effect of beta1- and beta2-adrenergic stimulation on energy expenditure, substrate oxidation, and UCP3 expression in humans.
American journal of physiology. Endocrinology and metabolism 20031001
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Effect of acute reduction of free fatty acids by acipimox on growth hormone-releasing hormone-induced GH secretion in type 1 diabetic patients.
Clinical endocrinology 20031001
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The decisive role of free fatty acids for protein conservation during fasting in humans with and without growth hormone.
The Journal of clinical endocrinology and metabolism 20030901
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Comparison between insulin tolerance test, growth hormone (GH)-releasing hormone (GHRH), GHRH plus acipimox and GHRH plus GH-releasing peptide-6 for the diagnosis of adult GH deficiency in normal subjects, obese and hypopituitary patients.
European journal of endocrinology 20030801
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Effect of diabetes mellitus on myocardial 18F-FDG SPECT using acipimox for the assessment of myocardial viability.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030601
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Molecular identification of nicotinic acid receptor.
Biochemical and biophysical research communications 20030328
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Molecular identification of high and low affinity receptors for nicotinic acid.
The Journal of biological chemistry 20030314
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Feasibility and image quality of dual-isotope SPECT using 18F-FDG and (99m)Tc-tetrofosmin after acipimox administration.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030201
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Diagnosis of growth hormone deficiency after pituitary surgery: the combined acipimox/GH-releasing hormone test.
Clinical endocrinology 20030201
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Acute lowering of circulating fatty acids improves insulin secretion in a subset of type 2 diabetes subjects.
American journal of physiology. Endocrinology and metabolism 20030101
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Effects of lowering circulating free fatty acid levels on protein metabolism in adult growth hormone deficient patients.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20021201
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Human serum adiponectin levels are not under short-term negative control by free fatty acids in vivo.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20021001
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Acipimox stimulates leptin production from isolated rat adipocytes.
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Mechanisms of leptin secretion from white adipocytes.
American journal of physiology. Cell physiology 20020701
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The effect of long-term pharmacological antilipolysis on substrate metabolism in growth hormone (GH)-substituted GH-deficient adults.
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Policosanol: a new treatment for cardiovascular disease?
Alternative medicine review : a journal of clinical therapeutic 20020601
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Long-term follow-up of patients with acute hypertriglyceridemia-induced pancreatitis.
Journal of clinical gastroenterology 20020401
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A pilot study of the long-term effects of acipimox in polycystic ovarian syndrome.
Human reproduction (Oxford, England) 20020301
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Effects of fatty acids on exercise plus insulin-induced glucose utilization in trained and sedentary subjects.
American journal of physiology. Endocrinology and metabolism 20020101
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Intimal redox stress: accelerated atherosclerosis in metabolic syndrome and type 2 diabetes mellitus. Atheroscleropathy.
Cardiovascular diabetology 20020101
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Safety and feasibility of cardiac FDG SPECT following oral administration of Acipimox, a nicotinic acid derivative: Comparison of image quality with hyperinsulinemic euglycemic clamping in nondiabetic patients.
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Effect of acipimox on plasma lipids and glucose/insulin in pregnant rats.
International journal of experimental diabetes research 20020101
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Inhibition of the rise in FFA by Acipimox partially prevents GH-induced insulin resistance in GH-deficient adults.
The Journal of clinical endocrinology and metabolism 20011201
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Metabolic and endocrine consequences of acute suppression of FFAs by acipimox in polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 20011101
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Pharmacological antilipolysis restores insulin sensitivity during growth hormone exposure.
Diabetes 20011001
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Lowering plasma free fatty acids with Acipimox mimics the antidiabetic effects of the beta 3-adrenergic agonist CL-316243 in obese Zucker diabetic fatty rats.
Metabolism: clinical and experimental 20010801
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Short-term Acipimox decreases the ability of plasma from Type 2 diabetic patients and healthy subjects to stimulate cellular cholesterol efflux: a potentially adverse effect on reverse cholesterol transport.
Diabetic medicine : a journal of the British Diabetic Association 20010601
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Evidence that amylin stimulates lipolysis in vivo: a possible mediator of induced insulin resistance.
American journal of physiology. Endocrinology and metabolism 20010401
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Effect of acute pharmacological modulation of plasma free fatty acids on GH secretion in acromegalic patients.
Clinical endocrinology 20010401
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The role of free fatty acids (FFA) in the regulation of intrahepatic fluxes of glucose and glycogen metabolism during short-term starvation in healthy volunteers.
Clinical nutrition (Edinburgh, Scotland) 20010401
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Characterization of a G protein-coupled receptor for nicotinic acid.
Molecular pharmacology 20010201
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Reducing plasma free fatty acids by acipimox improves glucose tolerance in high-fat fed mice.
Acta physiologica Scandinavica 20010201
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Effects of acipimox on the lipolysis rate in subcutaneous adipose tissue of obese subjects.
Diabetes/metabolism research and reviews 20010101
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18F-fluorodeoxyglucose accumulation in the heart, brain and skeletal muscle of rats; the influence of time after injection, depressed lipid metabolism and glucose-insulin.
Nuclear medicine review. Central & Eastern Europe 20010101
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Statins and peripheral neuropathy.
European journal of clinical pharmacology 19990101
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Restoration of growth hormone (GH) response to GH-releasing hormone in elderly and obese subjects by acute pharmacological reduction of plasma free fatty acids.
The Journal of clinical endocrinology and metabolism 19961101
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Acipimox-mediated plasma free fatty acid depression per se stimulates growth hormone (GH) secretion in normal subjects and potentiates the response to other GH-releasing stimuli.
The Journal of clinical endocrinology and metabolism 19960301
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Impaired growth hormone secretion in obese subjects is partially reversed by acipimox-mediated plasma free fatty acid depression.
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