512-04-9 | Diosgenin

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$13.00	$9.00
25g	98%	in stock	$24.00	$17.00
100g	98%	in stock	$78.00	$55.00
500g	98%	in stock	$252.00	$176.00

Description

• Catalog Number: AB49783
• Chemical Name: Diosgenin
• CAS Number: 512-04-9
• Molecular Formula: C27H42O3
• Molecular Weight: 414.6206
• MDL Number: MFCD00016887
• SMILES: C[C@@H]1CC[C@@]2(OC1)O[C@@H]1[C@H]([C@@H]2C)[C@@]2([C@@H](C1)[C@@H]1CC=C3[C@]([C@H]1CC2)(C)CC[C@@H](C3)O)C

Computed Properties

• Complexity: 746
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 11
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• XLogP3: 5.7

Literature

• Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation.

  Toxicology 20170301

• Polyphyllin I induces cell cycle arrest and apoptosis in human myeloma cells via modulating β-catenin signaling pathway.

  European journal of haematology 20161001

• Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats.

  Toxicology and applied pharmacology 20160815

• Effect of diosgenin on metabolic dysfunction: Role of ERβ in the regulation of PPARγ.

  Toxicology and applied pharmacology 20151201

• Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20151201

• Isolation and prevention of calcium oxalate-induced apoptotic death and oxidative stress in MDCK cells by diosgenin.

  Chemico-biological interactions 20141205

• Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways.

  Toxicology and applied pharmacology 20141201

• Dioscin enhances methotrexate absorption by down-regulating MDR1 in vitro and in vivo.

  Toxicology and applied pharmacology 20140601

• Protective effects of dioscin against alcohol-induced liver injury.

  Archives of toxicology 20140301

• Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines.

  Journal of biomedical science 20140101

• PPAR's and Diosgenin a chemico biological insight in NIDDM.

  Chemico-biological interactions 20131125

• Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways.

  Journal of applied toxicology : JAT 20130801

• Dioscin's antiviral effect in vitro.

  Virus research 20130301

• The antifungal activity and membrane-disruptive action of dioscin extracted from Dioscorea nipponica.

  Biochimica et biophysica acta 20130301

• Caveats of using acetaminophen hepatotoxicity models for natural product testing.

  Toxicology letters 20121123

• Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.

  Toxicology letters 20121002

• Cytotoxicity and apoptosis-inducing effect of steroidal saponins from Dioscorea zingiberensis Wright against cancer cells.

  Steroids 20121001

• Molluscicidal activity of Balanites aegyptiaca against Monacha cartusiana.

  Pharmaceutical biology 20121001

• Beneficial role of diosgenin on oxidative stress in aorta of streptozotocin induced diabetic rats.

  European journal of pharmacology 20120915

• Simultaneous quantification of Polyphyllin D and Paris H, two potential antitumor active components in Paris polyphylla by liquid chromatography-tandem mass spectrometry and the application to pharmacokinetics in rats.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120915

• Dioscin: a synergistic tyrosinase inhibitor from the roots of Smilax china.

  Food chemistry 20120915

• Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy.

  Fitoterapia 20120901

• Application of hypoiodite-mediated aminyl radical cyclization to synthesis of solasodine acetate.

  Steroids 20120901

• Steroidal saponins from Paris polyphylla var. yunnanensis.

  Phytochemistry 20120901

• Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKKβ and IRS-1 pathways.

  Atherosclerosis 20120801

• Synthesis and selective anticancer activity of steroidal glycoconjugates.

  European journal of medicinal chemistry 20120801

• Diosgenin hemihydrate.

  Acta crystallographica. Section E, Structure reports online 20120801

• Paris saponin II of Rhizoma Paridis--a novel inducer of apoptosis in human ovarian cancer cells.

  Bioscience trends 20120801

• Small molecular weight PEGylation of diosgenin in an in vivo animal study for diabetic auditory impairment treatment.

  Bioorganic & medicinal chemistry letters 20120715

• Diosgenin promotes oligodendrocyte progenitor cell differentiation through estrogen receptor-mediated ERK1/2 activation to accelerate remyelination.

  Glia 20120701

• In vitro propagation of Dioscorea alata var. purpurae.

  Applied biochemistry and biotechnology 20120701

• Chemical characteristics of saponins from Paris fargesii var. brevipetala and cytotoxic activity of its main ingredient, paris saponin H.

  Fitoterapia 20120601

• Cationic lipids containing cyclen and ammonium moieties as gene delivery vectors.

  Chemical biology & drug design 20120601

• A 90-day subchronic toxicological assessment of dioscin, a natural steroid saponin, in Sprague-Dawley rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501

• Behavioral and IL-2 responses to diosgenin in ovariectomized rats.

  The Chinese journal of physiology 20120430

• Anti-tumour and anti-oxidative potential of diosgenin against 7, 12-dimethylbenz(a)anthracene induced experimental oral carcinogenesis.

  Pathology oncology research : POR 20120401

• Regioselective cleavage of 22-oxo-23-spiroketals. Novel cholestanic frameworks with pyranone and cyclopentenone E rings on the side chain.

  Steroids 20120401

• [Novel derivatives of diosgenin: design, synthesis and anti-tumor activity].

  Yao xue xue bao = Acta pharmaceutica Sinica 20120401

• Antitumor promoting potential of selected phytochemicals derived from spices: a review.

  European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20120301

• A novel β-glucosidase from Aspergillus fumigates releases diosgenin from spirostanosides of Dioscorea zingiberensis C. H. Wright (DZW).

  World journal of microbiology & biotechnology 20120301

• Diosgenin induces apoptosis in IGF-1-stimulated human thyrocytes through two caspase-dependent pathways.

  Biochemical and biophysical research communications 20120210

• Improved production of transgenic Dioscorea zingiberensis (Dioscoreaceae) by Agrobacterium tumefaciens-mediated transformation.

  Genetics and molecular research : GMR 20120203

• Triterpene saponins of Quillaja saponaria show strong aphicidal and deterrent activity against the pea aphid Acyrthosiphon pisum.

  Pest management science 20120201

• Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins.

  Cancer biology & therapy 20120201

• Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties.

  Journal of neuroendocrinology 20120101

• Antidiabetic Activity of Gnidia glauca and Dioscorea bulbifera: Potent Amylase and Glucosidase Inhibitors.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Effects of auxins on the production of steroidal alkaloids in rapidly proliferating tissue and cell cultures of Solanum lyratum.

  Phytochemical analysis : PCA 20120101

• Saponins do not affect the ecdysteroid receptor complex but cause membrane permeation in insect culture cell lines.

  Journal of insect physiology 20120101

• Cancer cell signaling pathways targeted by spice-derived nutraceuticals.

  Nutrition and cancer 20120101

• Conversion of spirostane and solanidane into pregnane (1)introduction of oxygen function into C-23.

  Chemical & pharmaceutical bulletin 20120101

• Anti-tumour and immunomodulating activities of diosgenin, a naturally occurring steroidal saponin.

  Natural product research 20120101

• Study of lipid profile and parieto-temporal lipid peroxidation in AlCl₃ mediated neurotoxicity. Modulatory effect of fenugreek seeds.

  Lipids in health and disease 20120101

• Synthesis of silver nanoparticles using Dioscorea bulbifera tuber extract and evaluation of its synergistic potential in combination with antimicrobial agents.

  International journal of nanomedicine 20120101

• Current approaches toward production of secondary plant metabolites.

  Journal of pharmacy & bioallied sciences 20120101

• Antimicrobial activity of sesquiterpene lactones isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm.

  BMC complementary and alternative medicine 20120101

• Application of high-speed countercurrent chromatography-evaporative light scattering detection for the separation of seven steroidal saponins from Dioscorea villosa.

  Phytochemical analysis : PCA 20120101

• Phytochemicals from plants to combat cardiovascular disease.

  Current medicinal chemistry 20120101

• Two new steroidal saponins from the biotransformation product of the rhizomes of Dioscorea nipponica.

  Journal of Asian natural products research 20120101

• Solanum lyratum Extracts Induce Extrinsic and Intrinsic Pathways of Apoptosis in WEHI-3 Murine Leukemia Cells and Inhibit Allograft Tumor.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Functional herbal food ingredients used in type 2 diabetes mellitus.

  Pharmacognosy reviews 20120101

• Diosgenin Induces Apoptosis in HepG2 Cells through Generation of Reactive Oxygen Species and Mitochondrial Pathway.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Effects of various asparagus production methods on rutin and protodioscin contents in spears and cladophylls.

  Bioscience, biotechnology, and biochemistry 20120101

• Extraction optimization of water-extracted mycelial polysaccharide from endophytic fungus Fusarium oxysporum Dzf17 by response surface methodology.

  International journal of molecular sciences 20120101

• Anti-proliferation and anti-invasion effects of diosgenin on gastric cancer BGC-823 cells with HIF-1α shRNAs.

  International journal of molecular sciences 20120101

• Diosgenin is an exogenous activator of 1,25D₃-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice.

  Scientific reports 20120101

• Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma.

  PloS one 20120101

• Enhancement of diosgenin production in Dioscorea zingiberensis cell cultures by oligosaccharides from its endophytic fungus Fusarium oxysporum Dzf17.

  Molecules (Basel, Switzerland) 20111219

• Paris saponin I induces G₂/M cell cycle arrest and apoptosis in human gastric carcinoma SGC7901 cells.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20111201

• Diosgenin stimulates osteogenic activity by increasing bone matrix protein synthesis and bone-specific transcription factor Runx2 in osteoblastic MC3T3-E1 cells.

  The Journal of nutritional biochemistry 20111101

• Microbial transformations of diosgenin by the white-rot basidiomycete Coriolus versicolor.

  Journal of natural products 20111028

• Effects of polysaccharide elicitors from endophytic Fusarium oxysporium Dzf17 on growth and diosgenin production in cell suspension culture of Dioscorea zingiberensis.

  Molecules (Basel, Switzerland) 20111026

• Paris chinensis dioscin induces G2/M cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells.

  World journal of gastroenterology 20111021

• Relative feeding and development of armyworm on switchgrass and corn, and its potential effects on switchgrass grown for biomass.

  Journal of economic entomology 20111001

• Osteoprotective effect of Monascus-fermented dioscorea in ovariectomized rat model of postmenopausal osteoporosis.

  Journal of agricultural and food chemistry 20110914

• Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo.

  Journal of ethnopharmacology 20110901

• Synthesis and biological evaluation of the glycoside (25R)-3β,16β-diacetoxy-22-oxocholest-5-en-26-yl β-d-glucopyranoside: a selective anticancer agent in cervicouterine cell lines.

  European journal of medicinal chemistry 20110901

• Cationic lipids containing protonated cyclen and different hydrophobic groups linked by uracil-PNA monomer: synthesis and application for gene delivery.

  European journal of medicinal chemistry 20110901

• Pedalium murex Linn.: an overview of its phytopharmacological aspects.

  Asian Pacific journal of tropical medicine 20110901

• In vitro & in vivo estrogenic activity of glycoside fractions of Solanum nigrum fruit.

  The Indian journal of medical research 20110901

• Novel cationic lipids possessing protonated cyclen and imidazolium salt for gene delivery.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110801

• Synthesis, antiproliferative activity, acute toxicity and assessment of the antiandrogenic activities of new androstane derivatives.

  Archives of pharmacal research 20110701

• Cytotoxicity of active ingredients extracted from plants of the Brazilian 'Cerrado'.

  Natural product communications 20110701

• [Anti-inflammatory and analgesic effects of saponins from D. zingiberensis C. H. Wright and diosgenin derivative on mice].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20110701

• Chemoprevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by freeze-dried yam sanyaku and its constituent diosgenin.

  Cancer prevention research (Philadelphia, Pa.) 20110601

• The effects of wild ginger (Costus speciosus (Koen) Smith) rhizome extract and diosgenin on rat uterine contractions.

  Reproductive sciences (Thousand Oaks, Calif.) 20110601

• Identification of antiplatelet and acetylcholinesterase inhibitory constituents in betel nut.

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20110601

• Effects of diosgenin on cell proliferation induced by IGF-1 in primary human thyrocytes.

  Archives of pharmacal research 20110601

• Diosgenin suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition by down-regulation of Mdm2 and vimentin.

  Journal of agricultural and food chemistry 20110525

• Total synthesis of solamargine.

  Bioorganic & medicinal chemistry letters 20110515

• [Structure-activity relationship of diosgenin derivatives as Bcl-2 antagonists].

  Yao xue xue bao = Acta pharmaceutica Sinica 20110501

• [Studies on the chemical constituents from the flowers of Ophiopogon japonicus].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110501

• Diosgenin, a plant-derived sapogenin, exhibits antiviral activity in vitro against hepatitis C virus.

  Journal of natural products 20110425

• Anti-thrombosis effect of diosgenin extract from Dioscorea zingiberensis C.H. Wright in vitro and in vivo.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20110415

• Effect of Dioscorea opposita Thunb. (yam) supplementation on physicochemical and sensory characteristics of yogurt.

  Journal of dairy science 20110401

• [Determination of diosgenin and ruscogenin in Radix Ophiopogonis by nonaqueous capillary electrophoresis].

  Yao xue xue bao = Acta pharmaceutica Sinica 20110401

• [Effects of organic solvents on proliferation of Hela cells line].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110401

• The hypocholesterolemic and antioxidative effect of dietary diosgenin and chromium chloride supplementation on high-cholesterol fed Japanese quails.

  Pakistan journal of biological sciences : PJBS 20110401

• Formosanin C-inhibited pulmonary metastasis through repression of matrix metalloproteinases on mouse lung adenocarcinoma.

  Cancer biology & therapy 20110315

• Reversal effect of Dioscin on multidrug resistance in human hepatoma HepG2/adriamycin cells.

  European journal of pharmacology 20110305

• Application of proteomic and bioinformatic techniques for studying the hepatoprotective effect of dioscin against CCl₄-induced liver damage in mice.

  Planta medica 20110301

• Diosgenin modulates vascular smooth muscle cell function by regulating cell viability, migration, and calcium homeostasis.

  The Journal of pharmacology and experimental therapeutics 20110301

• Microbial transformation of diosgenin by filamentous fungus Cunninghamella echinulata.

  Journal of Asian natural products research 20110301

• Biochemical monitoring in fenugreek to develop functional food and medicinal plant variants.

  New biotechnology 20110227

• Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells.

  Cancer letters 20110227

• The effect of fenugreek on the gene expression of arachidonic acid metabolizing enzymes.

  Phytotherapy research : PTR 20110201

• Synthesis of new symmetrical bis-steroidal pyrazine analogues from diosgenin.

  Steroids 20110201

• Plant-derived bioactive compounds produced by endophytic fungi.

  Mini reviews in medicinal chemistry 20110201

• The synthesis of cholestane and furostan saponin analogues and the determination of sapogenin's absolute configuration at C-22.

  Steroids 20110101

• Simultaneous analysis of diosgenin and sarsasapogenin in Asparagus officinalis byproduct by thin-layer chromatography.

  Phytochemical analysis : PCA 20110101

• Antiproliferative effects of some novel synthetic solanidine analogs on HL-60 human leukemia cells in vitro.

  Steroids 20110101

• Toxic compound, anti-nutritional factors and functional properties of protein isolated from detoxified Jatropha curcas seed cake.

  International journal of molecular sciences 20110101

• New challenges in the new year for Phcog Mag.: 5 years of quality publication.

  Pharmacognosy magazine 20110101

• A growth factor attenuates HIV-1 Tat and morphine induced damage to human neurons: implication in HIV/AIDS-drug abuse cases.

  PloS one 20110101

• Traditional chinese medicines in treatment of patients with type 2 diabetes mellitus.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Diosgenin ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D-galactose.

  The American journal of Chinese medicine 20110101

• Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression.

  PloS one 20110101

• In Vitro and In Vivo Antimalarial Activity Assays of Seeds from Balanites aegyptiaca: Compounds of the Extract Show Growth Inhibition and Activity against Plasmodial Aminopeptidase.

  Journal of parasitology research 20110101

• Antihypertriglyceridemia and anti-inflammatory activities of monascus-fermented dioscorea in streptozotocin-induced diabetic rats.

  Experimental diabetes research 20110101

• Dioscorea phytocompounds enhance murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Effects of diosgenin on myometrial matrix metalloproteinase-2 and -9 activity and expression in ovariectomized rats.

  International journal of biological sciences 20110101

• Influence of Momordica charantia on oxidative stress-induced perturbations in brain monoamines and plasma corticosterone in albino rats.

  Indian journal of pharmacology 20110101

• Apoptosis of human ovarian cancer cells induced by Paris chinensis dioscin via a Ca(2+)-mediated mitochondrion pathway.

  Asian Pacific journal of cancer prevention : APJCP 20110101

• Diosgenin from Dioscorea nipponica ameliorates diabetic neuropathy by inducing nerve growth factor.

  Biological & pharmaceutical bulletin 20110101

• A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells.

  PloS one 20110101

• The chloroform fraction of Solanum nigrum suppresses nitric oxide and tumor necrosis factor-α in LPS-stimulated mouse peritoneal macrophages through inhibition of p38, JNK and ERK1/2.

  The American journal of Chinese medicine 20110101

• Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death.

  Molecular neurodegeneration 20110101

• A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity.

  Pharmacognosy reviews 20110101

• Dose-dependent effects, safety and tolerability of fenugreek in diet-induced metabolic disorders in rats.

  Lipids in health and disease 20110101

• Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System.

  International journal of Alzheimer's disease 20110101

• Anthelmintic activity of steroidal saponins from Paris polyphylla.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20101201

• Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues.

  Molecular nutrition & food research 20101101

• Determination of diosgenin content in medicinal plants with enzyme-linked immunosorbent assay.

  Planta medica 20101101

• Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft.

  Acta biochimica et biophysica Sinica 20101101

• Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica.

  Planta medica 20101001

• Chemical study and medical application of saponins as anti-cancer agents.

  Fitoterapia 20101001

• Investigating the relationship between cell cycle stage and diosgenin-induced megakaryocytic differentiation of HEL cells using sedimentation field-flow fractionation.

  Analytical and bioanalytical chemistry 20101001

• Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.

  Toxins 20101001

• [Protein and creatine supplements and erroneous diagnosis of kidney diseases].

  Praxis 20100908

• Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF-kappaB and AP-1 activation.

  International immunopharmacology 20100901

• Top 10 botanical ingredients in 2010 anti-aging creams.

  Journal of cosmetic dermatology 20100901

• [Them man and the root bulb that gave the idea of the oral contraceptive pill].

  Lakartidningen 20100901

• Apoptosis inducing activity of steroidal constituents from Solanum xanthocarpum and Asparagus racemosus.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20100801

• A sensitive indirect competitive enzyme-linked immunosorbent assay for the detection of sarsasapogenin in rat plasma.

  Acta pharmacologica Sinica 20100801

• Steroidal saponins from two species of Dracaena.

  Journal of natural products 20100723

• One unique steroidal sapogenin obtained through the microbial transformation of ruscogenin by Phytophthora cactorum ATCC 32134 and its potential inhibitory effect on tissue factor (TF) procoagulant activity.

  Bioorganic & medicinal chemistry letters 20100715

• Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells.

  Cancer letters 20100628

• Diosgenin, a plant-derived sapogenin, enhances regulatory T-cell immunity in the intestine of mice with food allergy.

  Journal of natural products 20100625

• Some biomedical applications of Balanites aegyptiaca grown naturally in radioactive area, Southeastern Desert, Egypt.

  Journal of hazardous materials 20100615

• Process optimization for the production of diosgenin with Trichoderma reesei.

  Bioprocess and biosystems engineering 20100601

• Diosgenin attenuates inflammatory changes in the interaction between adipocytes and macrophages.

  Molecular nutrition & food research 20100601

• Synthesis, antiproliferative, acute toxicity and assessment of antiandrogenic activities of some newly synthesized steroidal lactams.

  European journal of medicinal chemistry 20100601

• New dioscin-glycosidase hydrolyzing multi-glycosides of dioscin from Absidia strain.

  Journal of microbiology and biotechnology 20100601

• Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells.

  International journal of oncology 20100501

• Pharmacokinetics of methyl protodioscin in rats.

  Die Pharmazie 20100501

• Synthesis of 26-hydroxy-22-oxocholestanic frameworks from diosgenin and hecogenin and their in vitro antiproliferative and apoptotic activity on human cervical cancer CaSki cells.

  Bioorganic & medicinal chemistry 20100401

• Structural requirement of spirostanol glycosides for rat uterine contractility and mode of their synergism.

  The Journal of pharmacy and pharmacology 20100401

• [Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20100401

• Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis.

  Chemico-biological interactions 20100330

• Two 22S-solanidine-type steroidal alkaloids from Fritillaria anhuiensis.

  Fitoterapia 20100301

• Synthesis and anti-glioma activity of 25(R)-spirostan-3beta,5alpha,6beta,19-tetrol.

  Steroids 20100301

• Deacylation reactions of 20-acetyl dinorcholanic lactones and 20,23-diacetyl furost-22-enes.

  Steroids 20100301

• Hydroxylation of diosgenin by Absidia coerulea.

  Natural product communications 20100301

• Cholesterol oxidase ChoL is a critical enzyme that catalyzes the conversion of diosgenin to 4-ene-3-keto steroids in Streptomyces virginiae IBL-14.

  Applied microbiology and biotechnology 20100201

• Production of diosgenin from Dioscorea zingiberensis tubers through enzymatic saccharification and microbial transformation.

  Applied microbiology and biotechnology 20100201

• Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease.

  Neuroscience 20100120

• Qualitative and quantitative analysis of steroidal saponins in crude extracts from Paris polyphylla var. yunnanensis and P. polyphylla var. chinensis by high performance liquid chromatography coupled with mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20100105

• Hemolytic mechanism of dioscin proposed by molecular dynamics simulations.

  Journal of molecular modeling 20100101

• Biotransformation of steriodal saponins in Dioscorea zingiberensis C. H. Wright to diosgenin by Trichoderma harzianum.

  Applied microbiology and biotechnology 20100101

• [Effects of methyl protodioscin on [Ca2+]i and ATPase activity in cardiomyocytes and analysis of mechanisms].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101

• Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies.

  Mediators of inflammation 20100101

• In vitro tetraploid induction and generation of tetraploids from mixoploids in Dioscorea zingiberensis.

  Pharmacognosy magazine 20100101

• Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines.

  BMC complementary and alternative medicine 20100101

• Inhibition of TNF-α-induced adhesion molecule expression by diosgenin in mouse vascular smooth muscle cells via downregulation of the MAPK, Akt and NF-κB signaling pathways.

  Vascular pharmacology 20100101

• The effects of a commercially available botanical supplement on strength, body composition, power output, and hormonal profiles in resistance-trained males.

  Journal of the International Society of Sports Nutrition 20100101

• Synthesis and characterization of new aromatic esters based on 4,16-pregnadiene-6,20-dione skeleton.

  Chemistry Central journal 20100101

• The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents.

  Diabetes, metabolic syndrome and obesity : targets and therapy 20100101

• Development of a rapid HPLC-UV method for simultaneous quantification of protodioscin and rutin in white and green asparagus spears.

  Journal of food science 20100101

• Chemical constituents of Asparagus.

  Pharmacognosy reviews 20100101

• Assessment of anti-nociceptive efficacy of costus speciosus rhizome in swiss albino mice.

  Journal of advanced pharmaceutical technology & research 20100101

• Acute toxicity and sub-chronic toxicity of steroidal saponins from Dioscorea zingiberensis C.H.Wright in rodents.

  Journal of ethnopharmacology 20091210

• Structural analogues of diosgenyl saponins: synthesis and anticancer activity.

  Bioorganic & medicinal chemistry 20091115

• Colic caused by Panicum maximum toxicosis in equidae in northern Brazil.

  Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 20091101

• Enhancement of diosgenin production in Dioscorea zingiberensis cell culture by oligosaccharide elicitor from its endophytic fungus Fusarium oxysporum Dzf17.

  Natural product communications 20091101

• Diosgenin attenuates allergen-induced intestinal inflammation and IgE production in a murine model of food allergy.

  Planta medica 20091001

• [Determination of pseudoprodioscin in Dioscorea panthaica by HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091001

• Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells.

  International journal of cancer 20090815

• New microbiological transformations of steroids by Streptomyces virginiae IBL-14.

  Environmental science & technology 20090801

• Antilipoperoxidative and membrane stabilizing effect of diosgenin, in experimentally induced myocardial infarction.

  Molecular and cellular biochemistry 20090701

• A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation.

  Journal of cellular biochemistry 20090701

• [Seedling botanical characters and determination of effective components on Dioscorea zingerbrensis by space mutation].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090701

• [Chemical constituents from herb of Solanum lyratum].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090701

• Novel effects of diosgenin on skin aging.

  Steroids 20090601

• [Analysis of biochemical indices and efficient ingredients in autotetraploid of Dioscorea zingibiernsis].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090601

• Methyl 3β-methoxy-carbon-yloxy-4,4-di-methyl-17-oxo-16α-(3-oxobut-yl)-16β-carboxylate.

  Acta crystallographica. Section E, Structure reports online 20090601

• Synthesis and cytotoxicities of icogenin analogues with disaccharide residues.

  Bioorganic & medicinal chemistry letters 20090515

• Development and validation of a sensitive and rapid non-aqueous LC-ESI-MS/MS method for measurement of diosgenin in the plasma of normal and hyperlipidemic rats: a comparative study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090515

• Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent.

  Journal of lipid research 20090501

• Analysis of relationship between cell cycle stage and apoptosis induction in K562 cells by sedimentation field-flow fractionation.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090415

• Molecularly imprinted layer-coated silica nanoparticles toward highly selective separation of active diosgenin from Dioscorea nipponica Makino.

  Journal of chromatography. A 20090320

• Synthesis and biological activity of the (25R)-cholesten-26-oic acids--ligands for the hormonal receptor DAF-12 in Caenorhabditis elegans.

  Organic & biomolecular chemistry 20090307

• Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential.

  Cancer science 20090301

• Caprospinol: moving from a neuroactive steroid to a neurotropic drug.

  Expert opinion on investigational drugs 20090301

• In vitro and in vivo anticancer activity of steroid saponins of Paris polyphylla var. yunnanensis.

  Experimental oncology 20090301

• N-tert-Butyl-5α-androstane-17β-carboxamide.

  Acta crystallographica. Section E, Structure reports online 20090301

• Fenugreek: a naturally occurring edible spice as an anticancer agent.

  Cancer biology & therapy 20090201

• New thinking in the development of novel derivatization reagents for liquid chromatography-mass spectrometric detection.

  Biomedical chromatography : BMC 20090101

• Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea.

  Steroids 20090101

• Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla.

  Fitoterapia 20090101

• Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin.

  Nutrition and cancer 20090101

• Microbial biotransformation: recent developments on steroid drugs.

  Recent patents on biotechnology 20090101

• Polyphyllin D exerts potent anti-tumour effects on Lewis cancer cells under hypoxic conditions.

  The Journal of international medical research 20090101

• Yam (Dioscorea pseudojaponica Yamamoto) ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D-galactose.

  The American journal of Chinese medicine 20090101

• Distribution of glycoalkaloids in potato tubers of 59 accessions of two wild and five cultivated Solanum species.

  Journal of agricultural and food chemistry 20081224

• [Steroidal saponins from the plant Agave brittoniana with activity against the parasite Trichomona vaginalis].

  Revista de biologia tropical 20081201

• The best utilization of D. zingiberensis C.H. Wright by an eco-friendly process.

  Bioresource technology 20081001

• Potential of spice-derived phytochemicals for cancer prevention.

  Planta medica 20081001

• Efficient protocol for purification of diosgenin and two fatty acids from Rhizoma dioscoreae by SFE coupled with high-speed counter-current chromatography and evaporative light scattering detection.

  Journal of separation science 20081001

• Increased cyclooxygenase-2 and thromboxane synthase expression is implicated in diosgenin-induced megakaryocytic differentiation in human erythroleukemia cells.

  Analytical biochemistry 20080901

• Cancer is a preventable disease that requires major lifestyle changes.

  Pharmaceutical research 20080901

• Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways.

  Proteomics 20080801

• Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages.

  FEBS letters 20080709

• Synthesis of bis-diosgenin pyrazine dimers: new cephalostatin analogs.

  Steroids 20080701

• Preparative separation of dioscin derivatives from Dioscorea villosa by centrifugal partition chromatography coupled with evaporative light scattering detection.

  Journal of separation science 20080701

• [Study on optimization of the hydrolysis process of dioscin catalyzed by hydrochloric acid].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080701

• Study of diosgenin-induced apoptosis kinetics in K562 cells by Sedimentation Field Flow Fractionation.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080615

• Efficient synthesis of alpha- and beta-chacotriosyl glycosides using appropriate donors, and their cytotoxic activity.

  Carbohydrate research 20080609

• Effects of yam and diosgenin on calpain systems in skeletal muscle of ovariectomized rats.

  Taiwanese journal of obstetrics & gynecology 20080601

• [Determination of plasma protein binding rate of methyl protodioscin with ultrafiltration].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080601

• [Isolation and identification of major steroidal saponins of Paris polyphylla Smith var stenophylla Franch].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080501

• Development and validation of a liquid chromatography/tandem mass spectrometry assay for the quantification of methyl protodioscin in rat plasma: application to a pharmacokinetic study.

  Biomedical chromatography : BMC 20080401

• Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells.

  Cancer letters 20080318

• Synthesis and cytotoxic activity of diosgenyl saponin analogues.

  Bioorganic & medicinal chemistry 20080315

• Balanitin-6 and -7: diosgenyl saponins isolated from Balanites aegyptiaca Del. display significant anti-tumor activity in vitro and in vivo.

  International journal of oncology 20080101

• Salinity stress enhances production of solasodine in Solanum nigrum L.

  Chemical & pharmaceutical bulletin 20080101

• Biotransformation of cholesterol to diosgenin by freely suspended and immobilised cells of Dioscorea bulbifera L.

  Journal of Asian natural products research 20080101

• [Research on the application of supercritical fluid extraction of diosgenin of Smilax china].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080101

• Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives.

  Carbohydrate research 20071228

• Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation.

  FEBS letters 20071222

• Identification and characterization of several dietary alkaloids as weak inhibitors of hedgehog signaling.

  Toxicological sciences : an official journal of the Society of Toxicology 20071201

• Biotransformation of diosgenin to nuatigenin-type steroid by a newly isolated strain, Streptomyces virginiae IBL-14.

  Applied microbiology and biotechnology 20071201

• Dioscin (saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: a proteomic-based study.

  Journal of proteome research 20071201

• Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam (Dioscorea spp.), on high-cholesterol fed rats.

  Bioscience, biotechnology, and biochemistry 20071201

• Induction of growth hormone release by dioscin from Dioscorea batatas DECNE.

  Journal of biochemistry and molecular biology 20071130

• Mechanisms involved in the vasodilator effect induced by diosgenin in rat superior mesenteric artery.

  European journal of pharmacology 20071128

• Synthesis of neosaponins and neoglycolipids containing a chacotriosyl moiety.

  Carbohydrate research 20071105

• Diosgenin, a naturally occurring steroid [corrected] saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells.

  Cancer letters 20071008

• Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2.

  International journal of molecular medicine 20071001

• Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry.

  Analytica chimica acta 20070905

• Ultrastructural and intracellular chemical changes of a novel halophilic strain V430 of Staphylococcus saprophyticus under CaCl2 stress.

  Applied biochemistry and biotechnology 20070901

• [Studies on chemical constituents of Liriope platyphylla].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070901

• [Selection of the microorganism for dioscin hydrolyze].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070801

• Sedimentation field flow fractionation to study human erythroleukemia cell megakaryocytic differentiation after short period diosgenin induction.

  Journal of chromatography. A 20070720

• Bioidentical hormones for menopausal hormone therapy: variation on a theme.

  Journal of general internal medicine 20070701

• Diosgenin inhibits melanogenesis through the activation of phosphatidylinositol-3-kinase pathway (PI3K) signaling.

  Life sciences 20070627

• Immuno-stimulating properties of diosgenyl saponins isolated from Paris polyphylla.

  Bioorganic & medicinal chemistry letters 20070501

• Diosgenin, a steroidal sapogenin, enhances antigen-specific IgG2a and interferon-gamma expression in ovalbumin-sensitized BALB/c mice.

  Planta medica 20070501

• Determination of protodioscin in rat plasma by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401

• Genetic fidelity of in vitro regenerants, encapsulation of shoot tips and high diosgenin content in Dioscorea bulbifera L., a potential alternative source of diosgenin.

  Biotechnology letters 20070401

• Nitric oxide inhibitory substances from the rhizomes of Dioscorea membranacea.

  Journal of ethnopharmacology 20070212

• Medicinal flowers. XII.(1)) New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer.

  Chemical & pharmaceutical bulletin 20070201

• Biological activities and syntheses of steroidal saponins: the shark-repelling pavoninins.

  Lipids 20070201

• CHIH-DFT determination of the molecular structure and IR and UV spectra of solanidine.

  Journal of molecular modeling 20070101

• MAP kinase subtypes and Akt regulate diosgenin-induced apoptosis of rheumatoid synovial cells in association with COX-2 expression and prostanoid production.

  International journal of molecular medicine 20070101

• Efficient synthesis of solasodine, O-acetylsolasodine, and soladulcidine as anticancer steroidal alkaloids.

  Chemistry & biodiversity 20070101

• Influence of plant matrix on microwave-assisted extraction process. The case of diosgenin extracted from fenugreek (Trigonella foenum-graecum L.).

  Phytochemical analysis : PCA 20070101

• A validated quantitative thin-layer chromatographic method for estimation of diosgenin in various plant samples, extract, and market formulation.

  Journal of AOAC International 20070101

• Ethnobotanical remarks on Central and Southern Italy.

  Journal of ethnobiology and ethnomedicine 20070101

• Determination of saponins in the kernel cake of Balanites aegyptiaca by HPLC-ESI/MS.

  Phytochemical analysis : PCA 20070101

• Psychoimmunological effects of dioscorea in ovariectomized rats: role of anxiety level.

  Annals of general psychiatry 20070101

• Large scale analysis of genes contributing to the herbal preparation dependent hippocampal plasticity in postischemic rehabilitation.

  Vascular pharmacology 20070101

• Effects of domestic processing on steroidal saponins in Taiwanese yam cultivar (Dioscorea pseudojaponica Yamamoto).

  Journal of agricultural and food chemistry 20061227

• Anti-allergic substances from the rhizomes of Dioscorea membranacea.

  Bioorganic & medicinal chemistry 20061215

• Synthesis of three natural diosgenyl glycosides.

  Journal of Asian natural products research 20061201

• Synthesis and cytotoxicities of dioscin derivatives with decorated chacotriosyl residues.

  Bioorganic & medicinal chemistry letters 20061101

• Determination of ruscogenin in crude Chinese medicines and biological samples by immunoassay.

  Analytical and bioanalytical chemistry 20061101

• [Study on steroidal compounds from Dioscorea zingiberensis].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20061101

• [Study on steroidal saponins of Dioscorea septemloba thunb].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20061101

• Diabetes and sport: managing the complex interactions.

  British journal of hospital medicine (London, England : 2005) 20061001

• Intestinal lipids and minerals in streptozotocin-induced diabetic rats fed bitter yam (Dioscorea polygonoides) sapogenin extract.

  Pakistan journal of pharmaceutical sciences 20061001

• Pre-apoptotic sub-population cell sorting from diosgenin apoptosis induced 1547 cells by Sedimentation Field-Flow Fractionation. The effect of channel thickness on sorting performance.

  Journal of chromatography. A 20060922

• Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.

  Cancer letters 20060908

• The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice.

  Journal of lipid research 20060901

• Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines.

  Steroids 20060901

• Metabolism of tomato steroidal glycosides in humans.

  Chemical & pharmaceutical bulletin 20060901

• Megakaryocyte cell sorting from diosgenin-differentiated human erythroleukemia cells by sedimentation field-flow fractionation.

  Analytical biochemistry 20060801

• Short synthesis of 16beta-hydroxy-5alpha-cholestane-3,6-dione a novel cytotoxic marine oxysterol.

  Steroids 20060701

• Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: protection by diosgenin and L-deprenyl.

  Neurobiology of disease 20060701

• Microbial metabolism of methyl protodioscin by Aspergillus niger culture--a new androstenedione producing way from steroid.

  The Journal of steroid biochemistry and molecular biology 20060701

• Facile conversion of spirostan saponin into furostan saponin: synthesis of methyl protodioscin and its 26-thio-analogue.

  Organic letters 20060622

• [Effect of potassium level on output and diosgenin content of Dioscorea zingiberensisg].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060601

• Molecular targets of dietary agents for prevention and therapy of cancer.

  Biochemical pharmacology 20060514

• Effect of ethanol extract of dried Chinese yam (Dioscorea batatas) flour containing dioscin on gastrointestinal function in rat model.

  Archives of pharmacal research 20060501

• Intestinal disaccharidases and some renal enzymes in streptozotocin-induced diabetic rats fed sapogenin extract from bitter yam (Dioscorea polygonoides).

  Life sciences 20060425

• Proteomic approach to study the cytotoxicity of dioscin (saponin).

  Proteomics 20060401

• Diosgenin, a plant-derived sapogenin, stimulates Ca2+-activated K+ current in human cortical HCN-1A neuronal cells.

  Planta medica 20060401

• [Study on fertillizer application techniques of annual Dioscoreae zingiberensis].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060401

• Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression.

  Oncogene 20060309

• Steroidal saponins from roots of Asparagus officinalis.

  Steroids 20060201

• Role of MAPKs and NF-kappaB in diosgenin-induced megakaryocytic differentiation and subsequent apoptosis in HEL cells.

  International journal of oncology 20060101

• Reactions of 26-iodopseudodiosgenin and 26-iodopseudodiosgenone with various nucleophiles and pharmacological activities of the products.

  Chemical & pharmaceutical bulletin 20060101

• Diosgenin glucuronides from Solanum lyratum and their cytotoxicity against tumor cell lines.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101

• HIV neurotoxicity: potential therapeutic interventions.

  Journal of biomedicine & biotechnology 20060101

• Structural requirements of cholesterol for binding to Vibrio cholerae hemolysin.

  Microbiology and immunology 20060101

• Diosgenin contents and DNA fingerprint screening of various yam (Dioscorea sp.) genotypes.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101

• Synthesis of the shark repellent pavoninin-4.

  The Journal of organic chemistry 20051223

• Synthesis of 7alpha-hydroxy-dehydroepiandrosterone and 7beta-hydroxy-dehydroepiandrosterone.

  Steroids 20051215

• Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-kappaB binding.

  International journal of molecular medicine 20051201

• [Research on correlations of quality and growing environment of Smilax China].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20051201

• Hypoglycemic effects of steroidal sapogenins isolated from Jamaican bitter yam, Dioscorea polygonoides.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20051101

• Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft.

  Cancer biology & therapy 20051101

• Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts.

  Molecular pharmacology 20051001

• Alteration of the expression of adenosine triphosphate-binding cassette transporters associated with bile acid and cholesterol transport in the rat liver and intestine during cholestasis.

  Journal of gastroenterology and hepatology 20050901

• [Study on chemical constituents in total saponin from Trigonella foenum-graecum].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050901

• Purification and characterization of dioscin-alpha-L-rhamnosidase from pig liver.

  Chemical & pharmaceutical bulletin 20050801

• Characterization of the pharmacokinetics of dioscin in rat.

  Steroids 20050701

• Preparations of vitamin D analogs, spirostanols and furostanols from diosgenin and their cytotoxic activities.

  European journal of medicinal chemistry 20050701

• Liquid-liquid systems for acid hydrolysis of glycoalkaloids from Solanum tuberosum L. tuber sprouts and solanidine extraction.

  Medical science monitor : international medical journal of experimental and clinical research 20050701

• Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria.

  Cancer letters 20050628

• Abiotic metal stress enhances diosgenin yield in Dioscorea bulbifera L. cultures.

  Plant cell reports 20050601

• Electrochemical study of breast cancer cells MCF-7 and its application in evaluating the effect of diosgenin.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20050501

• Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.

  Journal of natural products 20050501

• [Effect of intestinal bacteria on metabolism of ophiopognin saponin D' in rats].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050401

• Determination of dioscin in rat plasma by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325

• Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion.

  The Journal of biological chemistry 20050311

• Elicitation of diosgenin production in Dioscorea floribunda by ethylene-generating agent.

  Fitoterapia 20050301

• Changes in some liver enzymes in streptozotocin-induced diabetic rats fed sapogenin extract from bitter yam (Dioscorea polygonoides) or commercial diosgenin.

  The West Indian medical journal 20050301

• [Separation and identification of diosgenin in Trigonella foenum-graecum L. and its compound preparation by gradient thin-layer chromatography].

  Se pu = Chinese journal of chromatography 20050301

• Fluorophore-appended steroidal saponin (dioscin and polyphyllin D) derivatives.

  Organic letters 20050217

• Structure-function relationship for saponin effects on cell cycle arrest and apoptosis in the human 1547 osteosarcoma cells: a molecular modelling approach of natural molecules structurally close to diosgenin.

  Bioorganic & medicinal chemistry 20050215

• Effects of steroidal glycoalkaloids from potatoes (Solanum tuberosum) on in vitro bovine embryo development.

  Animal reproduction science 20050201

• [Steroidal constituents from Dioscorea parviflora].

  Yao xue xue bao = Acta pharmaceutica Sinica 20050201

• Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells.

  Cancer letters 20050120

• Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis.

  Cancer chemotherapy and pharmacology 20050101

• Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8.

  Hepatology (Baltimore, Md.) 20050101

• Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3.

  Molecular diversity 20050101

• A novel glucosyltransferase involved in steroid saponin biosynthesis in Solanum aculeatissimum.

  Plant molecular biology 20050101

• Diosgenin dose-dependent apoptosis and differentiation induction in human erythroleukemia cell line and sedimentation field-flow fractionation monitoring.

  Analytical biochemistry 20041215

• Supercritical fluid extraction of sapogenins from tubers of Smilax china.

  Fitoterapia 20041201

• Clemmensen reduction of diosgenin and kryptogenin: synthesis of [16,16,22,22,23,23-(2)H(6)]-(25R)-26-hydroxycholesterol.

  Steroids 20041201

• [Effect of N, P, K on rhizome yield and diosgenin content of Dioscorea zingiberensis].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20041201

• Activation of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine isolated left anterior descending coronary artery by diosgenin.

  European journal of pharmacology 20041011

• Cytotoxicity of the phytosterol diosgenin and its derivatives in rat cultured hepatocytes and V79 fibroblasts.

  Human & experimental toxicology 20041001

• SdFFF monitoring of cellular apoptosis induction by diosgenin and different inducers in the human 1547 osteosarcoma cell line.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040905

• Diosgenin induces cell cycle arrest and apoptosis in HEL cells with increase in intracellular calcium level, activation of cPLA2 and COX-2 overexpression.

  International journal of oncology 20040901

• Phytochemical analysis and anti-allergic study of Agave intermixta Trel. and Cissus sicyoides L.

  The Journal of pharmacy and pharmacology 20040901

• Facile synthesis of saponins containing 2,3-branched oligosaccharides by using partially protected glycosyl donors.

  The Journal of organic chemistry 20040806

• Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040801

• Diosgenin induces apoptosis in HeLa cells via activation of caspase pathway.

  Acta pharmacologica Sinica 20040801

• Synthesis of bidesmosidic dihydrodiosgenin saponins bearing a 3-O-beta-chacotriosyl moiety.

  Carbohydrate research 20040712

• Microbial metabolism of pseudoprotodioscin.

  Planta medica 20040701

• The mitotic-arresting and apoptosis-inducing effects of diosgenyl saponins on human leukemia cell lines.

  Biological & pharmaceutical bulletin 20040701

• Diosgenin-3-O-alpha-L-rhamnopyranosyl-(1 --> 4)-beta-D-glucopyranoside obtained as a new anticancer agent from Dioscorea futschauensis induces apoptosis on human colon carcinoma HCT-15 cells via mitochondria-controlled apoptotic pathway.

  Journal of Asian natural products research 20040601

• Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells.

  Cell research 20040601

• [Studies on the dynamic trends of diosgenin content in vegetative organs of Dioscorea zingiberensis].

  Shi yan sheng wu xue bao 20040601

• Microarray analysis of gene expression on herbal glycoside recipes improving deficient ability of spatial learning memory in ischemic mice.

  Journal of neurochemistry 20040301

• In vivo antiosteoporotic activity of a fraction of Dioscorea spongiosa and its constituent, 22-O-methylprotodioscin.

  Planta medica 20040301

• Alpha-hydroxylation at C-15 and C-16 in cholesterol: synthesis of (25R)-5alpha-cholesta-3beta,15alpha,26-triol and (25R)-5alpha-cholesta-3beta,16alpha,26-triol from diosgenin.

  Organic letters 20040122

• Antifungal steroid saponins from Dioscorea cayenensis.

  Planta medica 20040101

• A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol.

  BMC medicine 20040101

• Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression.

  Arthritis research & therapy 20040101

• Final report of the amended safety assessment of Dioscorea Villosa (Wild Yam) root extract.

  International journal of toxicology 20040101

• Synthesis of rhamnosylated diosgenyl glucosides as mimetics of cytostatic steroidal saponins from Ornithogalum saindersiae and Galtonia candicans.

  Organic & biomolecular chemistry 20031221

• Isolation and identification of steroidal saponins in Taiwanese yam cultivar (Dioscorea pseudojaponica Yamamoto).

  Journal of agricultural and food chemistry 20031022

• Quantification of protodioscin and rutin in asparagus shoots by LC/MS and HPLC methods.

  Journal of agricultural and food chemistry 20031008

• [Study on the production condition of extraction in combination hydrolysis in situ for isolating diosgenin].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031001

• Furostanol saponins from Tribulus terrestris.

  Fitoterapia 20030901

• A new steroidal saponin from Dioscorea zingiberensis Wright.

  Natural product research 20030801

• [Apoptosis of human chronic myeloid leukemia k562 cell induced by prosapogenin B of dioscin (P.B) in vitro].

  Ai zheng = Aizheng = Chinese journal of cancer 20030801

• Regulation of biliary cholesterol secretion is associated with abcg5 and abcg8 expressions in the rats: effects of diosgenin and ethinyl estradiol.

  Hepatology research : the official journal of the Japan Society of Hepatology 20030801

• In vitro micropropagation, differentiation of aerial bulbils and tubers and diosgenin content in Dioscorea bulbifera.

  Planta medica 20030801

• Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents.

  Bioscience, biotechnology, and biochemistry 20030701

• [Sports and doping].

  Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology 20030701

• Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice.

  Journal of hepatology 20030601

• The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro.

  Cancer investigation 20030601

• Total synthesis of methyl protodioscin: a potent agent with antitumor activity.

  The Journal of organic chemistry 20030502

• [Advances in the study on Dioscorea zingiberensis C.H. Wright].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030501

• The synthesis of gracillin and dioscin: two typical representatives of spirostanol glycosides.

  Carbohydrate research 20030404

• Structural features of sterols required to inhibit human sperm capacitation.

  Biology of reproduction 20030401

• Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin and tigogenin, on human 1547 osteosarcoma cells.

  International journal of oncology 20030401

• Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): an evaluation using a rat model.

  Journal of alternative and complementary medicine (New York, N.Y.) 20030401

• Solanidine hydrolytic extraction and separation from the potato (Solanum tuberosum L.) vines by using solid-liquid-liquid systems.

  Journal of agricultural and food chemistry 20030326

• Protective effects of steroid saponins from Paris polyphylla var. yunnanensis on ethanol- or indomethacin-induced gastric mucosal lesions in rats: structural requirement for activity and mode of action.

  Bioorganic & medicinal chemistry letters 20030324

• Ovine metabolism of diosgenin coated on cellulose in relation to hepatogenous photosensitization of ruminants.

  Veterinary and human toxicology 20030201

• Regioselective cleavage of rings E and F in sarsasapogenin.

  Steroids 20030201

• Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants.

  Neurology 20030128

• Synthesis of monomethylated dioscin derivatives and their antitumor activities.

  Carbohydrate research 20030120

• Synthesis and induction of apoptosis in B cell chronic leukemia by diosgenyl 2-amino-2-deoxy-beta-D-glucopyranoside hydrochloride and its derivatives.

  Carbohydrate research 20030120

• Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030101

• Protodioscin isolated from fenugreek (Trigonella foenumgraecum L.) induces cell death and morphological change indicative of apoptosis in leukemic cell line H-60, but not in gastric cancer cell line KATO III.

  International journal of molecular medicine 20030101

• Biological activities of synthetic saponins and cardiac glycosides.

  Phytotherapy research : PTR 20030101

• The effects of sustained delivery of diosgenin on the adrenal gland of female rats.

  Biomedical sciences instrumentation 20030101

• Structural changes in the kidney associated with ovariectomy and diosgenin replacement therapy in adult female rats.

  Biomedical sciences instrumentation 20030101

• Genetic stability assessment of plants regenerated from cryopreserved embryogenic tissues of Dioscorea bulbifera l. Using RAPD, biochemical and morphological analysis.

  Cryo letters 20030101

• Electrospray ionization mass spectrometry of AZT H-phosphonates conjugated with steroids.

  Rapid communications in mass spectrometry : RCM 20030101

• Glycosyl trifluoroacetimidates. 2. Synthesis of dioscin and xiebai saponin I.

  The Journal of organic chemistry 20021213

• Synthesis of (25R)-26-hydroxycholesterol.

  Steroids 20021201

• Studies toward the synthesis of the shark repellent pavoninin-5.

  Lipids 20021201

• A facile approach to diosgenin and furostan type saponins bearing a 3beta-chacotriose moiety.

  Carbohydrate research 20021119

• Variation in diosgenin levels among 10 accessions of fenugreek seeds produced in western Canada.

  Journal of agricultural and food chemistry 20021009

• Determination of aculeatisides based on immunoassay using a polyclonal antibody against aculeatiside A.

  The Analyst 20021001

• [The antitumor activity of Diosgenin in vivo and in vitro].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20021001

• Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation.

  Developmental biology 20020915

• [Study on hydrolysis conditions of Dioscorea nipponica with uniform design method].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020901

• [Study on chemical constituents of rhizome of Anemone raddeana].

  Yao xue xue bao = Acta pharmaceutica Sinica 20020901

• [Intestinal bacteria metabolism of TSDP and characterization of metabolites in rats].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020901

• Preparations of heterospirostanols and their pharmacological activities.

  European journal of medicinal chemistry 20020801

• [Comparative study on anti-hypercholesterolemia activity of diosgenin and total saponin of Dioscorea panthaica].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020701

• Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests.

  Journal of natural products 20020601

• Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel.

  Planta medica 20020401

• Molecular cloning and functional expression of cDNAs encoding oxidosqualene cyclases from Costus speciosus.

  Biological & pharmaceutical bulletin 20020401

• [Isolation and identification of steroidal saponins in total saponin from Dioscorea nipponica Makino].

  Yao xue xue bao = Acta pharmaceutica Sinica 20020401

• [Advances in the study of Paris L. and its uses].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020301

• Meiosis activating sterols derived from diosgenin.

  Bioorganic & medicinal chemistry letters 20020225

• Chemical toxins and body defences.

  Biologist (London, England) 20020201

• Apoptosis induced by dioscin in Hela cells.

  Biological & pharmaceutical bulletin 20020201

• Influence of different light intensities on the content of diosgenin, lipids, carotenoids and fatty acids in leaves of Dioscorea zingiberensis.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101

• Low temperature crystal structure of natural diosgenone.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101

• Phospholipids modulate the substrate specificity of soluble UDP-glucose:steroid glucosyltransferase from eggplant leaves.

  Phytochemistry 20011101

• The isolation and identification of steroidal sapogenins in switchgrass.

  Journal of natural toxins 20011101

• Cytotoxic activities and structure-cytotoxic relationships of steroidal saponins.

  Biological & pharmaceutical bulletin 20011101

• A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells.

  FEBS letters 20011012

• [Screening of steroidal saponins from the bulbs of Lilium brownii var. colchesteri by combination of high performance liquid chromatography-electrospray ionization mass spectrometry and electron impact mass spectrometry].

  Se pu = Chinese journal of chromatography 20010901

• Regulation of biliary cholesterol secretion is independent of hepatocyte canalicular membrane lipid composition: a study in the diosgenin-fed rat model.

  Journal of hepatology 20010801

• [The change of diosgenin content in cultivated Dioscorea zingiberensis and D. panthaica from Guizhou province].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20010801

• Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women.

  Climacteric : the journal of the International Menopause Society 20010601

• An improved synthesis of the saponin, polyphyllin D.

  Carbohydrate research 20010309

• Effects of two saponins extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells.

  Biological & pharmaceutical bulletin 20010201

• Release of intermediate reactive hydrogen peroxide by macrophage cells activated by natural products.

  Biological & pharmaceutical bulletin 20010201

• The prevention of osteoporotic progression by means of steroid loaded TCPL drug delivery systems.

  Biomedical sciences instrumentation 20010101

• The use of estrogen, DHEA, and diosgenin in a sustained delivery setting as a novel treatment approach for osteoporosis in the ovariectomized adult rat model.

  Biomedical sciences instrumentation 20010101

• Inhibitory effect of steroidal alkaloids on drug transport and multidrug resistance in human cancer cells.

  Anticancer research 20010101

• C-27 and C-3 glucosylation of diosgenin by cell suspension cultures of Costus speciosus.

  Journal of Asian natural products research 20010101

• 13C cross-polarization MAS NMR study of some steroidal sapogenins.

  Solid state nuclear magnetic resonance 20010101

• Medicinal and ethnoveterinary remedies of hunters in Trinidad.

  BMC complementary and alternative medicine 20010101

• [Forgotten episodes of the birth of cortisone].

  Yakushigaku zasshi 20010101

• In vitro effect of fenugreek extracts on intestinal sodium-dependent glucose uptake and hepatic glycogen phosphorylase A.

  International journal of experimental diabetes research 20010101

• Effects of diosgenin, a plant-derived steroid, on bile secretion and hepatocellular cholestasis induced by estrogens in the rat.

  Hepatology (Baltimore, Md.) 19980701