518-28-5 | (10R,11R,15R,16R)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1(9),2,7-trien-12-one

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$26.00	$18.00
5g	98%	in stock	$34.00	$24.00
25g	98%	in stock	$90.00	$63.00
100g	98%	in stock	$261.00	$183.00

Description

• Catalog Number: AB53179
• Chemical Name: (10R,11R,15R,16R)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1(9),2,7-trien-12-one
• CAS Number: 518-28-5
• Molecular Formula: C22H22O8
• Molecular Weight: 414.4053
• MDL Number: MFCD00075290
• SMILES: COc1cc(cc(c1OC)OC)[C@H]1[C@H]2C(=O)OC[C@@H]2[C@H](c2c1cc1OCOc1c2)O

Computed Properties

• Complexity: 629
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 2

Literature

• Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.

  Science (New York, N.Y.) 20150911

• Antiplasmodial and Cytotoxic Triterpenoids from the Bark of the Cameroonian Medicinal Plant Entandrophragma congoënse.

  Journal of natural products 20150424

• 4'-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells.

  Chemico-biological interactions 20141205

• Antiplasmodial and cytotoxic dibenzofurans from Preussia sp. harboured in Enantia chlorantha Oliv.

  Fitoterapia 20140301

• Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.

  Bioorganic & medicinal chemistry 20140101

• Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.

  Scientific reports 20140101

• Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers.

  Bioorganic & medicinal chemistry 20131201

• Enantioselective synthesis of encecaline-derived potent antimalarial agents.

  Organic & biomolecular chemistry 20131114

• Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI).

  Journal of medicinal chemistry 20131010

• Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives.

  Journal of medicinal chemistry 20130926

• Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase.

  Bioorganic & medicinal chemistry 20130915

• Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives.

  European journal of medicinal chemistry 20130901

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.

  Journal of medicinal chemistry 20130711

• Antiprotozoal activity of Khaya anthotheca, (Welv.) C.D.C. a plant used by chimpanzees for self-medication.

  Journal of ethnopharmacology 20130502

• Synthesis and in vitro antimalarial testing of neocryptolepines: SAR study for improved activity by introduction and modifications of side chains at C2 and C11 on indolo[2,3-b]quinolines.

  Journal of medicinal chemistry 20130227

• Aminoalkyl derivatives of guanidine diaromatic minor groove binders with antiprotozoal activity.

  Journal of medicinal chemistry 20130214

• Antibacterial and antiplasmodial constituents of Beilschmiedia cryptocaryoides.

  Journal of natural products 20130125

• Next generation sequencing in predicting gene function in podophyllotoxin biosynthesis.

  The Journal of biological chemistry 20130104

• Chemotherapy-induced bowel obstruction in small cell lung cancer: a case report.

  Medical oncology (Northwood, London, England) 20121201

• Antileishmanial bis-arylimidamides: DB766 analogs modified in the linker region and bis-arylimidamide structure-activity relationships.

  Bioorganic & medicinal chemistry letters 20121115

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents.

  Bioorganic & medicinal chemistry 20121101

• Synthesis, characterization and biological evaluation of some novel 2,4-thiazolidinediones as potential cytotoxic, antimicrobial and antihyperglycemic agents.

  Bioorganic & medicinal chemistry letters 20121015

• Quantification of limonin in human urine using solid-phase extraction by LC-MS/MS.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20121015

• 2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani.

  Bioorganic & medicinal chemistry letters 20121001

• Young women's experiences of managing self-treatment for anogenital warts.

  Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives 20121001

• Adva-27a, a novel podophyllotoxin derivative found to be effective against multidrug resistant human cancer cells.

  Anticancer research 20121001

• Anti-mycobacterial natural products from the Canadian medicinal plant Juniperus communis.

  Journal of ethnopharmacology 20120928

• Ultrahigh pressure extraction of lignan compounds from Dysosma versipellis and purification by high-speed counter-current chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120915

• Topical treatments for cutaneous warts.

  The Cochrane database of systematic reviews 20120912

• 18F-FDG microPET imaging detects early transient response to an IGF1R inhibitor in genetically engineered rhabdomyosarcoma models.

  Pediatric blood & cancer 20120901

• CIL-102 binds to tubulin at colchicine binding site and triggers apoptosis in MCF-7 cells by inducing monopolar and multinucleated cells.

  Biochemical pharmacology 20120901

• IGF-1 alleviates ox-LDL-induced inflammation via reducing HMGB1 release in HAECs.

  Acta biochimica et biophysica Sinica 20120901

• Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins.

  Journal of medicinal chemistry 20120809

• Cytotoxic podophyllotoxin type-lignans from the steam bark of Bursera fagaroides var. fagaroides.

  Molecules (Basel, Switzerland) 20120809

• Nordic MCL2 trial update: six-year follow-up after intensive immunochemotherapy for untreated mantle cell lymphoma followed by BEAM or BEAC + autologous stem-cell support: still very long survival but late relapses do occur.

  British journal of haematology 20120801

• Synthesis and biological evaluation of novel 4β-(1,3,4-oxadiazole-2-amino)-podophyllotoxin derivatives.

  Bioorganic & medicinal chemistry letters 20120715

• Antitumor agents 294. Novel E-ring-modified camptothecin-4β-anilino-4'-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents.

  Bioorganic & medicinal chemistry 20120715

• Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies.

  Bioorganic & medicinal chemistry letters 20120715

• Cantharidin-podophylotoxin-salicylic acid versus cryotherapy in the treatment of plantar warts: a randomized prospective study.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20120701

• The effect of light on gene expression and podophyllotoxin biosynthesis in Linum album cell culture.

  Plant physiology and biochemistry : PPB 20120701

• Endophytic fungi: novel sources of anticancer lead molecules.

  Applied microbiology and biotechnology 20120701

• Synthesis and evaluation of novel podophyllotoxin analogs.

  Bioorganic & medicinal chemistry letters 20120701

• Novel 3-nitro-1H-1,2,4-triazole-based amides and sulfonamides as potential antitrypanosomal agents.

  Journal of medicinal chemistry 20120614

• One-step bulk preparation of calcium carbonate nanotubes and its application in anticancer drug delivery.

  Biological trace element research 20120601

• The use of sinecatechins (polyphenon E) ointment for treatment of external genital warts.

  Expert opinion on biological therapy 20120601

• Human papillomavirus-related genital disease in the immunocompromised host: Part II.

  Journal of the American Academy of Dermatology 20120601

• MYC+ diffuse large B-cell lymphoma is not salvaged by classical R-ICE or R-DHAP followed by BEAM plus autologous stem cell transplantation.

  Blood 20120501

• Synthesis and anticancer activity of 2-benzylidene indanones through inhibiting tubulin polymerization.

  Bioorganic & medicinal chemistry 20120501

• [Determination of podophyllotoxin and total lignans in Sinopodophyllum emodi].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501

• The HDAC inhibitor LBH589 enhances the antimyeloma effects of the IGF-1RTK inhibitor picropodophyllin.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20120415

• Synthesis, biological evaluation, and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania.

  Journal of medicinal chemistry 20120412

• Regulation by survivin of cancer cell death induced by F14512, a polyamine-containing inhibitor of DNA topoisomerase II.

  Apoptosis : an international journal on programmed cell death 20120401

• Multiple antitumor effects of picropodophyllin in colon carcinoma cell lines: clinical implications.

  International journal of oncology 20120401

• Condylomata acuminata in children.

  The Pediatric infectious disease journal 20120401

• Synthesis and comparative evaluation of 4-oxa- and 4-aza-podophyllotoxins as antiproliferative microtubule destabilizing agents.

  Bioorganic & medicinal chemistry letters 20120401

• Time-course changes in fungal elicitor-induced lignan synthesis and expression of the relevant genes in cell cultures of Linum album.

  Journal of plant physiology 20120315

• Synthesis and biological evaluation of 4β-sulphonamido and 4β-[(4'-sulphonamido)benzamide]podophyllotoxins as DNA topoisomerase-IIα and apoptosis inducing agents.

  Bioorganic & medicinal chemistry 20120315

• Polygamain, a new microtubule depolymerizing agent that occupies a unique pharmacophore in the colchicine site.

  Molecular pharmacology 20120301

• Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7.

  European journal of medicinal chemistry 20120301

• Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers.

  Bioorganic & medicinal chemistry 20120215

• Synthesis and antitumor activity of novel aroylthiourea derivatives of podophyllotoxin.

  Investigational new drugs 20120201

• In silico inspired design and synthesis of a novel tubulin-binding anti-cancer drug: folate conjugated noscapine (Targetin).

  Journal of computer-aided molecular design 20120201

• Synthesis and anti-protozoal activity of novel dihydropyrrolo[3,4-d][1,2,3]triazoles.

  European journal of medicinal chemistry 20120201

• Synthesis, characterization and in vitro biological evaluation of some novel diarylsulfonylureas as potential cytotoxic and antimicrobial agents.

  Bioorganic & medicinal chemistry letters 20120115

• Factors affecting podophyllotoxin yield in the ex situ grown Podophyllum hexandrum, an endangered alpine native of the western Himalayas.

  Journal of natural medicines 20120101

• Application of ultrasound as pretreatment for extraction of podophyllotoxin from rhizomes of Podophyllum peltatum.

  Ultrasonics sonochemistry 20120101

• Manipulation of heterogeneity product in 4'-demethylepipodophyllotoxin biotransformation process by using yeast extract as nitrogen source.

  Applied microbiology and biotechnology 20120101

• QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells.

  Cancer science 20120101

• Synthesis and biological evaluation of 4α/4β-imidazolyl podophyllotoxin analogues as antitumor agents.

  Archiv der Pharmazie 20120101

• Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents.

  European journal of medicinal chemistry 20120101

• Isolation and Identification of Endophytic Fungi from Actinidia macrosperma and Investigation of Their Bioactivities.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Novel biotransformation process of podophyllotoxin to 4 β-sulfur-substituted podophyllum derivates with anti-tumor activity by Penicillium purpurogenum Y.J. Tang.

  Current medicinal chemistry 20120101

• In vitro antitumour activity of stearic acid-g-chitosan oligosaccharide polymeric micelles loading podophyllotoxin.

  Journal of microencapsulation 20120101

• Insulin-like growth factors promote vasculogenesis in embryonic stem cells.

  PloS one 20120101

• Current approaches toward production of secondary plant metabolites.

  Journal of pharmacy & bioallied sciences 20120101

• Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity.

  Scientific reports 20120101

• How morphological constraints affect axonal polarity in mouse neurons.

  PloS one 20120101

• Anogenital squamous cell carcinoma in neglected patient.

  Bratislavske lekarske listy 20120101

• Inhibition mechanism and model of an angiotensin I-converting enzyme (ACE)-inhibitory hexapeptide from yeast (Saccharomyces cerevisiae).

  PloS one 20120101

• Modified carbon nanotube paste electrode for voltammetric determination of carbidopa, folic Acid, and tryptophan.

  Journal of analytical methods in chemistry 20120101

• Cytotoxicity and cell death mechanisms induced by the polyamine-vectorized anti-cancer drug F14512 targeting topoisomerase II.

  Biochemical pharmacology 20111215

• Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxicity and cell cycle effects.

  Bioorganic & medicinal chemistry letters 20111215

• Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents.

  Bioorganic & medicinal chemistry 20111215

• Design and synthesis of N-phosphoryl peptide modified podophyllotoxin derivatives as potent anticancer agents.

  Protein and peptide letters 20111201

• Absolute configuration of podophyllotoxin related lignans from Bursera fagaroides using vibrational circular dichroism.

  Phytochemistry 20111201

• Identification of lignans and related compounds in Anthriscus sylvestris by LC-ESI-MS/MS and LC-SPE-NMR.

  Phytochemistry 20111201

• Facile synthesis of new 4-aza-podophyllotoxin analogs via microwave-assisted multi-component reactions and evaluation of their cytotoxic activity.

  Bioorganic & medicinal chemistry letters 20111201

• Inhibition of CYP3A4 and CYP2C9 by podophyllotoxin: implication for clinical drug-drug interactions.

  Journal of biosciences 20111201

• Stress-mediated adaptive response leading to genetic diversity and instability in metabolite contents of high medicinal value: an overview on Podophyllum hexandrum.

  Omics : a journal of integrative biology 20111201

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• Synthesis and cytotoxicity evaluation of novel podophyllotoxin derivatives.

  Archiv der Pharmazie 20111101

• Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis).

  Bioorganic & medicinal chemistry letters 20111101

• [Molecular determinants of response to topoisomerase II inhibitors].

  Bulletin du cancer 20111101

• 9-{[4-(Dimethyl-amino)-benzyl]amino}-5-(4-hy-droxy-3,5-dimeth-oxy-phenyl)-5,5a,8a,9-tetra-hydro-furo[3',4':6,7]naphtho-[2,3-d][1,3]dioxol-6(8H)-one methanol monosolvate.

  Acta crystallographica. Section E, Structure reports online 20111101

• In vitro antiprotozoal activity of extracts of five Turkish Lamiaceae species.

  Natural product communications 20111101

• Drug-induced senescence generates chemoresistant stemlike cells with low reactive oxygen species.

  The Journal of biological chemistry 20111028

• Polyalkoxybenzenes from plants. 5. Parsley seed extract in synthesis of azapodophyllotoxins featuring strong tubulin destabilizing activity in the sea urchin embryo and cell culture assays.

  Journal of medicinal chemistry 20111027

• 5k, a novel β-O-demethyl-epipodophyllotoxin analogue, inhibits the proliferation of cancer cells in vitro and in vivo via the induction of G2 arrest and apoptosis.

  Investigational new drugs 20111001

• Genital warts and cost of care in England.

  Sexually transmitted infections 20111001

• Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives.

  Bioorganic & medicinal chemistry letters 20111001

• [Anti-MDR tumor mechanism of CIP-36, a podophyllotoxin derivative].

  Yao xue xue bao = Acta pharmaceutica Sinica 20111001

• Antimalarial β-carbolines from the New Zealand ascidian Pseudodistoma opacum.

  Journal of natural products 20110923

• N-hydroxyethyl-4-aza-didehydropodophyllotoxin derivatives as potential antitumor agents.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110918

• Natural products-based insecticidal agents 11. Synthesis and insecticidal activity of novel 4α-arylsulfonyloxybenzyloxy-2β-chloropodophyllotoxin derivatives against Mythimna separata Walker in vivo.

  Bioorganic & medicinal chemistry letters 20110915

• Podophyllotoxin and other aryltetralin lignans from Eriope latifolia and Eriope blanchetii.

  Natural product research 20110901

• Podophyllotoxin-derived insecticidal agents: part XIII--evaluation of insecticidal activity of podophyllotoxin derivatives against Brontispa longissima.

  Natural product research 20110901

• Synthesis and biological evaluation of derivatives of 4-deoxypodophyllotoxin as antitumor agents.

  European journal of medicinal chemistry 20110901

• Anticancer lignans--from discovery to biotechnology.

  Mini reviews in medicinal chemistry 20110901

• Recent advances in semisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: an update (2008-2010).

  Mini reviews in medicinal chemistry 20110901

• Synthesis of 4β-triazole-podophyllotoxin derivatives by azide-alkyne cycloaddition and biological evaluation as potential antitumor agents.

  European journal of medicinal chemistry 20110901

• Seasonal variations in the deoxypodophyllotoxin content and yield of Anthriscus sylvestris L. (Hoffm.) grown in the field and under controlled conditions.

  Journal of agricultural and food chemistry 20110810

• Podophyllotoxin and deoxypodophyllotoxin in Juniperus bermudiana and 12 other Juniperus species: optimization of extraction, method validation, and quantification.

  Journal of agricultural and food chemistry 20110810

• Association of HSV reactivation and pro-inflammatory cytokine levels with the severity of stomatitis after BEAM chemotherapy and autologous SCT.

  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20110801

• Antiplasmodial and cytotoxicity evaluation of 3-functionalized 2-azetidinone derivatives.

  Bioorganic & medicinal chemistry letters 20110801

• Synthesis and biological evaluation of 4β-acrylamidopodophyllotoxin congeners as DNA damaging agents.

  Bioorganic & medicinal chemistry 20110801

• Does immunotherapy of viral warts provide beneficial effects when it is combined with conventional therapy?

  Annals of dermatology 20110801

• 9-[(Furan-2-ylmeth-yl)amino]-5-(3,4,5-trimeth-oxy-phen-yl)-5,5a,8a,9-tetra-hydro-furo[3',4':6,7]naphtho-[2,3-d][1,3]dioxol-6(8H)-one.

  Acta crystallographica. Section E, Structure reports online 20110801

• Stereoselective synthesis of 4α-alkyloxy-2-α/β-bromopodophyllotoxin derivatives as insecticidal agents.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20110718

• Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.

  Bioorganic & medicinal chemistry 20110715

• Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.

  Journal of medicinal chemistry 20110714

• Antimalarial pyrido[1,2-a]benzimidazoles.

  Journal of medicinal chemistry 20110714

• Unexpectedly convenient and stereoselective synthesis of 4α-acyloxy-2-chloropodophyllotoxins in the presence of BF₃ ·Et₂O.

  Bioorganic & medicinal chemistry letters 20110701

• N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

  Journal of medicinal chemistry 20110623

• Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis.

  Journal of medicinal chemistry 20110623

• Three new cytotoxic aryltetralin lignans from Sinopodophyllum emodi.

  Bioorganic & medicinal chemistry letters 20110615

• Development and characterization of molecularly imprinted polymers for the selective enrichment of podophyllotoxin from traditional Chinese medicines.

  Analytica chimica acta 20110610

• Application of ionic liquids in the microwave-assisted extraction of podophyllotoxin from Chinese herbal medicine.

  The Analyst 20110607

• Expression and effects of inhibition of type I insulin-like growth factor receptor tyrosine kinase in mantle cell lymphoma.

  Haematologica 20110601

• 4β-[(4-Alkyl)-1,2,3-triazol-1-yl] podophyllotoxins as anticancer compounds: design, synthesis and biological evaluation.

  European journal of medicinal chemistry 20110601

• 9-[(2-Chloro-benz-yl)amino]-5-(3,4,5-trimeth-oxy-phen-yl)-5,5a,8a,9-tetra-hydro-furo[3',4':6,7]naphtho-[2,3-d][1,3]dioxol-6(8H)-one.

  Acta crystallographica. Section E, Structure reports online 20110601

• 9-{[4-(Dimethyl-amino)-benz-yl]amino}-5-(3,4,5-trimeth-oxy-phen-yl)-5,5a,8a,9-tetra-hydro-furo[3',4':6,7]naphtho-[2,3-d][1,3]dioxol-6(8H)-one.

  Acta crystallographica. Section E, Structure reports online 20110601

• Synthesis of 4β-carbamoyl epipodophyllotoxins as potential antitumour agents.

  Bioorganic & medicinal chemistry 20110501

• Synthesis and antitumor activity of novel podophyllotoxin derivatives against multidrug-resistant cancer cells.

  Journal of Asian natural products research 20110501

• Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma.

  PLoS neglected tropical diseases 20110501

• [Resources of survey in rare and endangered medicinal plant Sinopodophyllum emodi].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110501

• [Review on biosynthesis of podophyllotoxin].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110501

• Involvement of P-glycoprotein and CYP 3A4 in the enhancement of etoposide bioavailability by a piperine analogue.

  Chemico-biological interactions 20110425

• Didemnidines A and B, indole spermidine alkaloids from the New Zealand ascidian Didemnum sp.

  Journal of natural products 20110425

• Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense.

  Journal of natural products 20110425

• Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage.

  Biochemistry 20110419

• A synthetic route to highly substituted 1,2,3,4-tetrahydroisoquinolines via Yb(OTf)3 -catalyzed diastereoselective ring opening of bridged oxazolidines: asymmetric synthesis of 2-azapodophyllotoxin.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20110418

• Peripheral sensitization caused by insulin-like growth factor 1 contributes to pain hypersensitivity after tissue injury.

  Pain 20110401

• Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents.

  Bioorganic & medicinal chemistry 20110401

• β-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.

  Bioorganic & medicinal chemistry 20110401

• (90)Y ibritumomab tiuxetan (Zevalin) combined with BEAM (Z -BEAM) conditioning regimen plus autologous stem cell transplantation in relapsed or refractory low-grade CD20-positive B-cell lymphoma. A GELA phase II prospective study.

  Clinical lymphoma, myeloma & leukemia 20110401

• Efficacy and safety of imiquimod versus podophyllotoxin in the treatment of anogenital warts.

  Sexually transmitted diseases 20110301

• Synthesis and evaluation of aroylthiourea derivatives of 4-β-amino-4'-O-demethyl-4-desoxypodophyllotoxin as novel topoisomerase II inhibitors.

  European journal of medicinal chemistry 20110301

• Immunobiological properties of selected natural and chemically modified phenylpropanoids.

  Interdisciplinary toxicology 20110301

• Determination of picropodophyllin and its isomer podophyllotoxin in human serum samples with electrospray ionization of hexylamine adducts by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110215

• Preclinical activity of F14512, designed to target tumors expressing an active polyamine transport system.

  Investigational new drugs 20110201

• A novel bis-indole destabilizes microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer.

  Cancer chemotherapy and pharmacology 20110201

• Plant-derived bioactive compounds produced by endophytic fungi.

  Mini reviews in medicinal chemistry 20110201

• Deoxypodophyllotoxin Induces a Th1 Response and Enhances the Antitumor Efficacy of a Dendritic Cell-based Vaccine.

  Immune network 20110201

• Role of the adrenergic system in a mouse model of oxygen-induced retinopathy: antiangiogenic effects of beta-adrenoreceptor blockade.

  Investigative ophthalmology & visual science 20110105

• Podophyllum hexandrum-Mediated Survival Protection and Restoration of Other Cellular Injuries in Lethally Irradiated Mice.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Andrographolide: a new plant-derived antineoplastic entity on horizon.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• REC-2006-A Fractionated Extract of Podophyllum hexandrum Protects Cellular DNA from Radiation-Induced Damage by Reducing the Initial Damage and Enhancing Its Repair In Vivo.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Chemometric evaluation of the anti-cancer pro-drug podophyllotoxin and potential therapeutic analogues in Juniperus and Podophyllum species.

  Phytochemical analysis : PCA 20110101

• Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation.

  Bioorganic & medicinal chemistry 20110101

• An efficient one-pot synthesis of benzothiazolo-4β-anilino-podophyllotoxin congeners: DNA topoisomerase-II inhibition and anticancer activity.

  Bioorganic & medicinal chemistry letters 20110101

• Synthesis and biological evaluation of new 4β-anilino-4'-O-demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents.

  European journal of medicinal chemistry 20110101

• Antimicrobial topical agents used in the vagina.

  Current problems in dermatology 20110101

• The use of endophytes to obtain bioactive compounds and their application in biotransformation process.

  Biotechnology research international 20110101

• Molecular characterization of acquired tolerance of tumor cells to picropodophyllin (PPP).

  PloS one 20110101

• Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells.

  Molecular cancer 20110101

• Molecular characterization of Chinese hamster cells mutants affected in adenosine kinase and showing novel genetic and biochemical characteristics.

  BMC biochemistry 20110101

• Antiproliferation and cell apoptosis inducing bioactivities of constituents from Dysosma versipellis in PC3 and Bcap-37 cell lines.

  Cell division 20110101

• Toxicity and neuropharmacological effects of elenine.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Apoptotic mechanism of human leukemia K562/A02 cells induced by magnetic iron oxide nanoparticles co-loaded with daunorubicin and 5-bromotetrandrin.

  International journal of nanomedicine 20110101

• Antiprotozoal activities of organic extracts from French marine seaweeds.

  Marine drugs 20110101

• Role of Apoptotic Proteins in REC-2006 Mediated Radiation Protection in Hepatoma Cell Lines.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Synthetic and application perspectives of azapodophyllotoxins: alternative scaffolds of podophyllotoxin.

  Current medicinal chemistry 20110101

• An integrated Drosophila model system reveals unique properties for F14512, a novel polyamine-containing anticancer drug that targets topoisomerase II.

  PloS one 20110101

• Imiquimod 3.75% cream applied daily to treat anogenital warts: combined results from women in two randomized, placebo-controlled studies.

  Infectious diseases in obstetrics and gynecology 20110101

• Assessment of anti-cytogenotoxic effects of quercetin in animals treated with topotecan.

  Oxidative medicine and cellular longevity 20110101

• Acetonic extract of Buxus sempervirens induces cell cycle arrest, apoptosis and autophagy in breast cancer cells.

  PloS one 20110101

• Microwave-assisted extraction of oleanolic acid and ursolic acid from Ligustrum lucidum Ait.

  International journal of molecular sciences 20110101

• CCND1 as a predictive biomarker of neoadjuvant chemotherapy in patients with locally advanced head and neck squamous cell carcinoma.

  PloS one 20110101

• Reduction of atherosclerotic lesions in rabbits treated with etoposide associated with cholesterol-rich nanoemulsions.

  International journal of nanomedicine 20110101

• Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signaling.

  PloS one 20110101

• Identification of cytotoxic drugs that selectively target tumor cells with MYC overexpression.

  PloS one 20110101

• The integrated HIV-1 provirus in patient sperm chromosome and its transfer into the early embryo by fertilization.

  PloS one 20110101

• [Comparative assessment of the methods of treatment of Condylomata acuminata].

  Akusherstvo i ginekologiia 20110101

• Synthesis of 4β-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities.

  Bioorganic & medicinal chemistry 20101215

• Design, synthesis, and biological evaluation of the first podophyllotoxin analogues as potential vascular-disrupting agents.

  ChemMedChem 20101203

• Role of radiation dose in the risk of secondary leukemia after a solid tumor in childhood treated between 1980 and 1999.

  International journal of radiation oncology, biology, physics 20101201

• Pharmacological effect of deoxypodophyllotoxin: a medicinal agent of plant origin, on mammalian neurons.

  Neurotoxicology 20101201

• Optimization of podophyllotoxin extraction method from Linum album cell cultures.

  Pharmaceutical biology 20101201

• Development of predictive quantitative structure-activity relationship models of epipodophyllotoxin derivatives.

  Journal of biomolecular screening 20101201

• The binding modes and binding affinities of epipodophyllotoxin derivatives with human topoisomerase IIα.

  Journal of molecular graphics & modelling 20101201

• Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway.

  The Journal of biological chemistry 20101126

• Salicylic acid improves podophyllotoxin production in cell cultures of Linum album by increasing the expression of genes related with its biosynthesis.

  Biotechnology letters 20101101

• Synthesis and cytotoxicity evaluation of novel 1,4-disubstituted 1,2,3-triazoles via CuI catalysed 1,3-dipolar cycloaddition.

  European journal of medicinal chemistry 20101101

• QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids.

  European journal of medicinal chemistry 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections.

  Bioorganic & medicinal chemistry 20101101

• A fluorescent biomarker of the polyamine transport system to select patients with AML for F14512 treatment.

  Leukemia research 20101001

• Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agents.

  Bioorganic & medicinal chemistry 20101001

• Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin.

  Journal of mass spectrometry : JMS 20101001

• [Topical imiquimod for the treatment of anogenital warts in an infant].

  Annales de dermatologie et de venereologie 20101001

• [Effect of deoxypodophyllotoxin on membrane potential of dorsal unpaired median neurons and its relationship with sodium channel].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20101001

• IGF-1 receptor inhibition by picropodophyllin in medulloblastoma.

  Biochemical and biophysical research communications 20100903

• Natural products-based insecticidal agents 7. Semisynthesis and insecticidal activity of novel 4alpha-alkyloxy-2-chloropodophyllotoxin derivatives against Mythimna separata Walker in vivo.

  Bioorganic & medicinal chemistry letters 20100901

• Drug-induced regulation of target expression.

  PLoS computational biology 20100901

• Antiprotozoal steroidal saponins from the marine sponge Pandaros acanthifolium.

  Journal of natural products 20100827

• Immunomagnetic selection of CD34(+) cells carried out in cryopreserved cell concentrates from a paediatric patient affected with non-Hodgkin lymphoma.

  Transfusion medicine (Oxford, England) 20100801

• Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.

  European journal of medicinal chemistry 20100801

• Natural products-based insecticidal agents 6. Design, semisynthesis, and insecticidal activity of novel monomethyl phthalate derivatives of podophyllotoxin against Mythimna separata Walker in vivo.

  Bioorganic & medicinal chemistry letters 20100801

• Podophyllotoxin derivatives show activity against Brontispa longissima larvae.

  Natural product communications 20100801

• Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: a new potential therapy for the treatment of melanoma.

  Experimental cell research 20100715

• Regioselective synthesis and in vitro anticancer activity of 4-aza-podophyllotoxin derivatives catalyzed by L-proline.

  Journal of combinatorial chemistry 20100712

• Molecular characterization and marker based chemotaxonomic studies of Podophyllum hexandrum Royle.

  Fitoterapia 20100601

• Molecular modeling and structure-activity relationship of podophyllotoxin and its congeners.

  Journal of biomolecular screening 20100601

• Pegfilgrastim appears equivalent to daily dosing of filgrastim to treat neutropenia after autologous peripheral blood stem cell transplantation in patients with non-Hodgkin lymphoma.

  Clinical lymphoma, myeloma & leukemia 20100601

• [Quantitative determination of podophyllotoxin in dermal and blood microdialysis samples of rats by liquid chromatography-tandem mass spectrometry].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100601

• Selective insulin-like growth factor-I antagonist inhibits mouse embryo development in a dose-dependent manner.

  Fertility and sterility 20100515

• Inhibitory effects of deoxypodophyllotoxin from Anthriscus sylvestris on human CYP2C9 and CYP3A4.

  Planta medica 20100501

• 6-methoxypodophyllotoxin-7-O-n-hexanoate, a new aryltetralin lignan ester from seeds of Linum flavum.

  Planta medica 20100501

• Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays.

  European journal of medicinal chemistry 20100501

• Thyroid hormone-mediated growth and differentiation of growth plate chondrocytes involves IGF-1 modulation of beta-catenin signaling.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100501

• Search for new and novel chemotherapeutics for the treatment of human malignancies.

  Mini reviews in medicinal chemistry 20100501

• Jacaranone-derived glucosidic esters from Jacaranda glabra and their activity against Plasmodium falciparum.

  Journal of natural products 20100423

• Insulin-like growth factor-I receptor in proliferation and motility of pancreatic cancer.

  World journal of gastroenterology 20100421

• Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo.

  Bioorganic & medicinal chemistry letters 20100415

• 5-FU for genital warts in non-immunocompromised individuals.

  The Cochrane database of systematic reviews 20100414

• Characterization of the colchicine binding site on avian tubulin isotype betaVI.

  Biochemistry 20100406

• First synthesis and biological evaluation of novel spin-labeled derivatives of deoxypodophyllotoxin.

  European journal of medicinal chemistry 20100401

• Cytotoxicity and apoptosis induced by a new podophyllotoxin glucoside in human hepatoma (HepG2) cells.

  Canadian journal of physiology and pharmacology 20100401

• Comparison of the cytotoxic effects of Juniperus sabina and Zataria multiflora extracts with Taxus baccata extract and Cisplatin on normal and cancer cell lines.

  Pharmacognosy magazine 20100401

• The in vitro and in vivo anti-tumor effect of layered double hydroxides nanoparticles as delivery for podophyllotoxin.

  International journal of pharmaceutics 20100330

• Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.

  Journal of natural products 20100326

• Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi.

  Bioorganic & medicinal chemistry letters 20100315

• Updated biotechnological approaches developed for 2,7'-cyclolignan production1.

  Biotechnology and applied biochemistry 20100312

• Podophyllotoxin analogues active versus Trypanosoma brucei.

  Bioorganic & medicinal chemistry letters 20100301

• A QSAR study on the cytotoxicity of podophyllotoxin analogues against various cancer cell lines.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20100301

• Antiproliferative cardenolides from Pentopetia androsaemifolia Decne. from the Madagascar rain forest.

  Indian journal of experimental biology 20100301

• 6-{[(Benz-yloxy)carbon-yl]-oxy}-2-methyl-hexa-hydro-pyrano[3,2-d][1,3]dioxin-7,8-diyl bis-(chloro-acetate).

  Acta crystallographica. Section E, Structure reports online 20100301

• 7-p-Tolyl-10,11-dihydro-benzo[h]furo[3,4-b]quinolin-8(7H)-one.

  Acta crystallographica. Section E, Structure reports online 20100301

• Podophyllum hexandrum as a potential botanical supplement for the medical management of nuclear and radiological emergencies (NREs) and free radical-mediated ailments: leads from in vitro/in vivo radioprotective efficacy evaluation.

  Journal of dietary supplements 20100301

• Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives.

  Journal of medicinal chemistry 20100211

• Synthesis and biological evaluation of new podophyllic aldehyde derivatives with cytotoxic and apoptosis-inducing activities.

  Journal of medicinal chemistry 20100211

• A novel podophyllotoxin derivative (YB-1EPN) induces apoptosis and down-regulates express of P-glycoprotein in multidrug resistance cell line KBV200.

  European journal of pharmacology 20100210

• A novel biotransformation process of 4'-demethylepipodophyllotoxin to 4'-demethylepipodophyllic acid by Bacillus fusiformis CICC 20463, Part II: process optimization.

  Bioprocess and biosystems engineering 20100201

• Tuned C-H functionalization to construct aza-podophyllotoxin/aza-conidendrin derivatives by means of domino cyclization.

  Chemistry, an Asian journal 20100201

• Novel semisynthetic spin-labeled derivatives of podophyllotoxin with cytotoxic and antioxidative activity.

  Bioorganic & medicinal chemistry letters 20100201

• Novel 4 beta-anilino-podophyllotoxin derivatives: design synthesis and biological evaluation as potent DNA-topoisomerase II poisons and anti-MDR agents.

  Molecular bioSystems 20100201

• Consensus conference on the use of 90-yttrium-ibritumomab tiuxetan therapy in clinical practice. A project of the Italian society of hematology.

  American journal of hematology 20100201

• Design and synthesis of C-ring lactone- and lactam-based podophyllotoxin analogues as anticancer agents.

  Chemical & pharmaceutical bulletin 20100201

• Reversal of mdr1-mediated multidrug resistance in human leukemia cells by a new spin-labeled derivative of podophyllotoxin.

  Die Pharmazie 20100201

• Design, synthesis and biological evaluation of novel spin-labeled derivatives of podophyllotoxin.

  Natural product communications 20100201

• [Comparison of the biodistribution and PET imaging with (11)C-PDT and (18)F-FDG in the mouse model of lung adenocarcinoma].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20100201

• Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells.

  Cancer letters 20100128

• Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles.

  Journal of medicinal chemistry 20100114

• A facile construction strategy of stable lipid nanoparticles for drug delivery using a hydrogel-thickened microemulsion system.

  Nanotechnology 20100108

• Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates.

  European journal of medicinal chemistry 20100101

• Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines.

  Bioorganic & medicinal chemistry 20100101

• Verteporfin photodynamic therapy of retinal capillary hemangioblastoma in von Hippel-Lindau disease.

  Indian journal of ophthalmology 20100101

• Podophyllotoxin induces CREB phosphorylation and CRE-driven gene expression via PKA but not MAPKs.

  Molecules and cells 20100101

• Deoxypodophyllotoxin inhibits the expression of intercellular adhesion molecule-1 induced by tumor necrosis factor-alpha in murine lung epithelial cells.

  Biological & pharmaceutical bulletin 20100101

• Molecular bases of liver cancer refractoriness to pharmacological treatment.

  Current medicinal chemistry 20100101

• Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma.

  Neuro-oncology 20100101

• Inhibitory activity of marine sponge-derived natural products against parasitic protozoa.

  Marine drugs 20100101

• The quality of life of patients with genital warts: a qualitative study.

  BMC public health 20100101

• The onconeural antigen cdr2 is a novel APC/C target that acts in mitosis to regulate c-myc target genes in mammalian tumor cells.

  PloS one 20100101

• Tubulin binding cofactor C (TBCC) suppresses tumor growth and enhances chemosensitivity in human breast cancer cells.

  BMC cancer 20100101

• A novel synthetic analog of 5, 8-disubstituted quinazolines blocks mitosis and induces apoptosis of tumor cells by inhibiting microtubule polymerization.

  PloS one 20100101

• Griseofulvin stabilizes microtubule dynamics, activates p53 and inhibits the proliferation of MCF-7 cells synergistically with vinblastine.

  BMC cancer 20100101

• A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds.

  PloS one 20100101

• Bromopyrrole alkaloids as lead compounds against protozoan parasites.

  Marine drugs 20100101

• Sustained spindle-assembly checkpoint response requires de novo transcription and translation of cyclin B1.

  PloS one 20100101

• Production of podophyllotoxin in Linum linearifolium in vitro cultures.

  Pharmacognosy magazine 20100101

• Equivalence of pegfilgrastim and filgrastim in lymphoma patients treated with BEAM followed by autologous stem cell transplantation.

  Oncology 20100101

• Traditional herbal medicine in far-west Nepal: a pharmacological appraisal.

  Journal of ethnobiology and ethnomedicine 20100101

• Quick and simple detection technique to assess the binding of antimicrotubule agents to the colchicine-binding site.

  Biological procedures online 20100101

• Warts (genital).

  BMJ clinical evidence 20100101

• Anticancer drugs from marine flora: an overview.

  Journal of oncology 20100101

• Medical radiation countermeasures for nuclear and radiological emergencies: Current status and future perspectives.

  Journal of pharmacy & bioallied sciences 20100101

• Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs.

  Pharmacognosy reviews 20100101

• A multicentre, randomised, double-blind, placebo controlled study of cryotherapy versus cryotherapy and podophyllotoxin cream as treatment for external anogenital warts.

  Sexually transmitted infections 20091201

• Abnormal blood vessels formed by human liver cavernous hemangioma endothelial cells in nude mice are suitable for drug evaluation.

  Microvascular research 20091201

• Apoptosis of human Burkitt's lymphoma cells induced by 2-N,N-diethylaminocarbonyloxymethyl-1-diphenylmethyl-4-(3,4,5-trimethoxybenzoyl) piperazine hydrochloride (PMS-1077).

  Archives of pharmacal research 20091201

• 4-Des-oxy-4β-(4-methoxy-carbonyl-1,2,3-triazol-1-yl)podophyllotoxin dichloro-methane solvate.

  Acta crystallographica. Section E, Structure reports online 20091201

• Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones.

  Bioorganic & medicinal chemistry 20091115

• Anticancer agents derived from natural products.

  Mini reviews in medicinal chemistry 20091101

• Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues.

  Bioorganic & medicinal chemistry 20091015

• Prognostic factors for the response to treatment in males with genital warts.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20091001

• Imiquimod 5% cream for external genital or perianal warts in human immunodeficiency virus-positive patients treated with highly active antiretroviral therapy: an open-label, noncomparative study.

  The British journal of dermatology 20091001

• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

  Nature chemical biology 20091001

• Phase II study of combination chemotherapy with etoposide and ifosfamide in patients with heavily pretreated recurrent or persistent epithelial ovarian cancer.

  Journal of Korean medical science 20091001

• Natural products-based insecticidal agents 4. Semisynthesis and insecticidal activity of novel esters of 2-chloropodophyllotoxin against Mythimna separata Walker in vivo.

  Bioorganic & medicinal chemistry letters 20090915

• Semisynthesis and quantitative structure-activity relationship (QSAR) study of novel aromatic esters of 4'-demethyl-4-deoxypodophyllotoxin as insecticidal agents.

  Journal of agricultural and food chemistry 20090909

• Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.

  European journal of medicinal chemistry 20090901

• Aspergillus fumigatus Fresenius, an endophytic fungus from Juniperus communis L. Horstmann as a novel source of the anticancer pro-drug deoxypodophyllotoxin.

  Journal of applied microbiology 20090901

• Podophyllum hexandrum fraction (REC-2006) shows higher radioprotective efficacy in the p53-carrying hepatoma cell line: a role of cell cycle regulatory proteins.

  Integrative cancer therapies 20090901

• The influence of bioactive oxylipins from marine diatoms on invertebrate reproduction and development.

  Marine drugs 20090901

• Beta-amyloid monomers are neuroprotective.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090826

• Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine.

  Journal of medicinal chemistry 20090813

• Novel biotransformation process of podophyllotoxin to produce podophyllic acid and picropodophyllotoxin by Pseudomonas aeruginosa CCTCC AB93066. Part I: process development.

  Bioprocess and biosystems engineering 20090801

• Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis.

  Bioorganic & medicinal chemistry letters 20090801

• pY-STAT3 and p53 expression predict outcome for poor prognosis diffuse large B-cell lymphoma treated with high dose chemotherapy and autologous stem cell transplantation.

  Leukemia & lymphoma 20090801

• Giant condyloma with demise secondary to meningococcemia in an infant boy.

  Journal of pediatric urology 20090801

• Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines.

  Molecular cancer therapeutics 20090801

• Deoxypodophyllotoxin, flavolignan, from Anthriscus sylvestris Hoffm. inhibits migration and MMP-9 via MAPK pathways in TNF-alpha-induced HASMC.

  Vascular pharmacology 20090701

• The management of condyloma acuminata in the pediatric population.

  Pediatric annals 20090701

• Insecticidal heterolignans--tubuline polymerization inhibitors with activity against chewing pests.

  Bioorganic & medicinal chemistry 20090615

• Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase.

  Bioorganic & medicinal chemistry letters 20090601

• Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis.

  Journal of chemical biology 20090601

• Synthesis and antiparasitic and antifungal evaluation of 2'-arylsubstituted-1H,1'H-[2,5']bisbenzimidazolyl-5-carboxamidines.

  European journal of medicinal chemistry 20090501

• HPLC-DAD and HPLC-ESI-MS separation, determination and identification of the spin-labeled diastereoisomers of podophyllotoxin.

  Journal of separation science 20090501

• [Stem cell therapy in multiple sclerosis: a clinical update].

  Zeitschrift fur Rheumatologie 20090501

• Synthesis and biological evaluation of novel conjugates of podophyllotoxin and 5-FU as antineoplastic agents.

  Bioorganic & medicinal chemistry 20090415

• Structure-activity study of pentamidine analogues as antiprotozoal agents.

  Journal of medicinal chemistry 20090409

• Molecular modelling evaluation of the cytotoxic activity of podophyllotoxin analogues.

  Journal of computer-aided molecular design 20090401

• Novel biotransformation process of podophyllotoxin to produce podophyllic acid and picropodophyllotoxin by Pseudomonas aeruginosa CCTCC AB93066, part II: process optimization.

  Bioresource technology 20090401

• Yttrium-90 ibritumomab tiuxetan doses calculated to deliver up to 15 Gy to critical organs may be safely combined with high-dose BEAM and autologous transplantation in relapsed or refractory B-cell non-Hodgkin's lymphoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090401

• L1EPO, a novel podophyllotoxin derivative overcomes P-glycoprotein-mediated multidrug resistance in K562/A02 cell line.

  Biological & pharmaceutical bulletin 20090401

• Germinating seeds of the mung bean, Vigna radiata (Fabaceae), as a model for the preliminary evaluation of cytotoxic effects of drugs.

  Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20090401

• [Genital warts].

  Praxis 20090318

• 10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

  Journal of medicinal chemistry 20090312

• Green tea catechins for treatment of external genital warts.

  American journal of obstetrics and gynecology 20090301

• Diagnosis and management of hypersensitivity reactions related to common cancer chemotherapy agents.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20090301

• Effects of zearalenone and alpha-Zearalenol in comparison with Raloxifene on T47D cells.

  Toxicology mechanisms and methods 20090301

• Enantioselective sequential conjugate addition-allylation reactions: a concise total synthesis of (+)-podophyllotoxin.

  Organic letters 20090205

• Preparation, characterization, and anti-tumor property of podophyllotoxin-loaded solid lipid nanoparticles.

  Nanotechnology 20090204

• Antiplasmodial and antitrypanosomal activities of aminobicyclo[2.2.2]octyl omega-aminoalkanoates.

  European journal of medicinal chemistry 20090201

• Redox-active dinitrodiphenylthioethers against Leishmania: synthesis, structure-activity relationships and mechanism of action studies.

  Bioorganic & medicinal chemistry 20090115

• Comparison of podophyllotoxin and imiquimod as anal condyloma acuminata therapy.

  Dermatology online journal 20090115

• Acute leukemia as a secondary malignancy in children and adolescents: current findings and issues.

  Cancer 20090101

• A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007.

  Current medicinal chemistry 20090101

• Applying linear interaction energy method for binding affinity calculations of podophyllotoxin analogues with tubulin using continuum solvent model and prediction of cytotoxic activity.

  Journal of molecular graphics & modelling 20090101

• [Adverse muscle effects of a podofyllotoxin-containing cytotoxic drug product with simvastatin].

  Duodecim; laaketieteellinen aikakauskirja 20090101

• Podophyllin, but not the constituents quercetin or kaempferol, induced genotoxicity in vitro and in vivo through ROS production.

  Drug and chemical toxicology 20090101

• The role of biotechnology in the production of the anticancer compound podophyllotoxin.

  Methods in molecular biology (Clifton, N.J.) 20090101

• Small-cell prostate carcinoma: A retrospective analysis of five newly reported cases.

  Indian journal of urology : IJU : journal of the Urological Society of India 20090101

• Interferon for the treatment of genital warts: a systematic review.

  BMC infectious diseases 20090101

• Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters.

  PloS one 20090101

• Sexually transmitted papillomavirus infections: epidemiology pathogenesis, clinic, morphology, important differential diagnostic aspects, current diagnostic and treatment options.

  Anais brasileiros de dermatologia 20090101

• Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening.

  PloS one 20090101

• 7-Methyl-9-p-tolyl-4,9-dihydro-furo[3,4-b]quinolin-1(3H)-one.

  Acta crystallographica. Section E, Structure reports online 20090101

• Selection methodology with scoring system: application to Mexican plants producing podophyllotoxin related lignans.

  Journal of ethnopharmacology 20081208

• Effect of aeration on production of anticancer lignans by cell suspension cultures of Linum album.

  Applied biochemistry and biotechnology 20081201

• F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system.

  Cancer research 20081201

• Uveal melanoma and macular degeneration: molecular biology and potential therapeutic applications.

  Acta ophthalmologica 20081201

• 4-Des-oxy-4β-[(5-meth-oxy-1H-indol-3-yl)oxalylamino]podophyllotoxin methanol solvate.

  Acta crystallographica. Section E, Structure reports online 20081201

• Separation, determination and identification of the diastereoisomers of podophyllotoxin and its esters by high-performance liquid chromatography/tandem mass spectrometry.

  Journal of chromatography. A 20081114

• Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans.

  Journal of medicinal chemistry 20081113

• Anal intraepithelial neoplasia in HIV infection.

  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20081101

• Introduction: Uveal melanoma.

  Acta ophthalmologica 20081101

• The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.

  Acta ophthalmologica 20081101

• Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma.

  Acta ophthalmologica 20081101

• Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor.

  Acta ophthalmologica 20081101

• Studies on novel 4beta-[(4-substituted)-1,2,3-triazol-1-yl] podophyllotoxins as potential anticancer agents.

  European journal of medicinal chemistry 20081001

• Improved podophyllotoxin production by transformed cultures of Linum album.

  Biotechnology journal 20081001

• Synthesis and structure-activity relationship of 3-phenylquinoxaline 1,4-di-N-oxide derivatives as antimalarial agents.

  European journal of medicinal chemistry 20080901

• Co-culture of arbuscular mycorrhiza-like fungi (Piriformospora indica and Sebacina vermifera) with plant cells of Linum album for enhanced production of podophyllotoxins: a first report.

  Biotechnology letters 20080901

• Keratinocyte growth factor is effective in the prevention of intestinal mucositis in patients with hematological malignancies treated with high-dose chemotherapy and autologous hematopoietic SCT: a video-capsule endoscopy study.

  Bone marrow transplantation 20080901

• Antiprotozoal activities of heterocyclic-substituted xanthones from the marine-derived fungus Chaetomium sp.

  Journal of natural products 20080901

• Modulation of gamma radiation-inflicted damage in Swiss albino mice by an alcoholic fraction of Podophyllum hexandrum rhizome.

  Journal of medicinal food 20080901

• Synthesis and biological evaluation of 4beta-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxins as potential anticancer agents.

  Chemistry & biodiversity 20080901

• Structure-activity relationship studies on a novel class of antiproliferative agents derived from Lavendustin A. Part I: Ring A modifications.

  Bioorganic & medicinal chemistry 20080815

• Noninvasive real-time imaging of intima thickness after rat carotid artery balloon injury using ultrasound biomicroscopy.

  Atherosclerosis 20080801

• New picropodophyllin analogs via palladium-catalyzed allylic alkylation-Hiyama cross-coupling sequences.

  The Journal of organic chemistry 20080801

• Treatments for genital warts.

  Journal of drugs in dermatology : JDD 20080801

• [Effect of podophyllotoxin on human gastric cancer cell line SGC 7901].

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20080801

• Gallic acid-based indanone derivatives as anticancer agents.

  Bioorganic & medicinal chemistry letters 20080715

• Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis.

  Hepatology (Baltimore, Md.) 20080701

• Comorbidities, not age, impact outcomes in autologous stem cell transplant for relapsed non-Hodgkin lymphoma.

  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20080701

• The naturally occurring flavolignan, deoxypodophyllotoxin, inhibits lipopolysaccharide-induced iNOS expression through the NF-kappaB activation in RAW264.7 macrophage cells.

  Biological & pharmaceutical bulletin 20080701

• Modern management of external genital warts.

  Journal of lower genital tract disease 20080701

• Metabolic stereoselectivity of cytochrome P450 3A4 towards deoxypodophyllotoxin: In silico predictions and experimental validation.

  European journal of medicinal chemistry 20080601

• Inhibitors of tubulin polymerization: synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III.

  Bioorganic & medicinal chemistry 20080601

• Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma.

  Investigative ophthalmology & visual science 20080601

• Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor.

  Investigative ophthalmology & visual science 20080601

• Design, synthesis and cytotoxicity of novel podophyllotoxin derivatives.

  Chemical & pharmaceutical bulletin 20080601

• Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.

  Bioorganic & medicinal chemistry 20080515

• Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes.

  British journal of cancer 20080506

• Design and effective synthesis of the first 4-aza-2,3-didehydropodophyllotoxin rigid aminologue: a N-methyl-4-[(3,4,5-trimethoxyphenyl)amino)]-1,2-dihydroquinoline-lactone.

  The Journal of organic chemistry 20080502

• Insulin growth factor signaling mediates neuron-like differentiation of adipose-tissue-derived stem cells.

  Differentiation; research in biological diversity 20080501

• [Interest of lignans in prevention and treatment of cancers].

  Medecine sciences : M/S 20080501

• [Effects of podophyllotoxin solid lipid nanoparticles on proliferation and apoptosis of cervical carcinoma cells].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080501

• [Biotransformation of podophyllotoxin by cell suspension culture and root culture of Rheum palmatum].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501

• Structural simplification of bioactive natural products with multicomponent synthesis. 2. antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones.

  Journal of medicinal chemistry 20080424

• Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.

  Biochemistry 20080415

• Docetaxel-induced mitotic arrest in epithelium of gallbladder: a hitherto unreported occurrence.

  International journal of surgical pathology 20080401

• Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum.

  Journal of medicinal chemistry 20080313

• Synthesis of novel derivatives of bispodophyllotoxin as potential antineoplastic agents--part XVI.

  Natural product research 20080310

• Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1.

  Oncogene 20080306

• The construction and characterization of layered double hydroxides as delivery vehicles for podophyllotoxins.

  Journal of materials science. Materials in medicine 20080301

• Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin.

  Molecular pharmacology 20080301

• Dose-escalated CHOP and tailored intensification with IFE according to early response and followed by BEAM/autologous stem-cell transplantation in poor-risk aggressive B-cell lymphoma: a prospective study from the GEL-TAMO Study Group.

  European journal of haematology 20080301

• Be wary, this is not a case of vulval warts!

  International journal of STD & AIDS 20080301

• Novel three-component synthesis and antiproliferative properties of diversely functionalized pyrrolines.

  Bioorganic & medicinal chemistry letters 20080215

• Seleno-podophyllotoxin derivatives induce hepatoma SMMC-7721 cell apoptosis through Bax pathway.

  Cell biology international 20080201

• Design, synthesis, and biological testing of 4beta-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin analogues as antitumor agents.

  Archiv der Pharmazie 20080201

• Anti-osteosarcoma effects and mechanisms of 4-O-amino-phenol-4'-demethylepipodophyllotoxin ether.

  The Journal of pharmacy and pharmacology 20080201

• Metabolic profiling of lignan variability in Linum species of section Syllinum native to Bulgaria.

  Planta medica 20080201

• Exogenous hormones affecting morphology and biosynthetic potential of hairy root line (LYR2i) of Linum album.

  Journal of bioscience and bioengineering 20080201

• Advances in the use of topical imiquimod to treat dermatologic disorders.

  Therapeutics and clinical risk management 20080201

• Synthesis and antiprotozoal activities of simplified analogs of naphthylisoquinoline alkaloids.

  European journal of medicinal chemistry 20080101

• BEAC or BEAM high-dose chemotherapy followed by autologous stem cell transplantation in non-Hodgkin's lymphoma patients: comparative analysis of efficacy and toxicity.

  Annals of hematology 20080101

• UDP-glucose:(6-methoxy)podophyllotoxin 7-O-glucosyltransferase from suspension cultures of Linum nodiflorum.

  Phytochemistry 20080101

• Phase II trial of a transplantation regimen of yttrium-90 ibritumomab tiuxetan and high-dose chemotherapy in patients with non-Hodgkin's lymphoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080101

• Characterization of in vitro metabolites of deoxypodophyllotoxin in human and rat liver microsomes using liquid chromatography/tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20080101

• A fragmentation study of two compounds related to 4'-demethylepipodophyllotoxin in negative ion electrospray ionization by MSn ion-trap time-of-flight mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20080101

• Adding a quadrivalent human papillomavirus vaccine to the UK cervical cancer screening programme: A cost-effectiveness analysis.

  Cost effectiveness and resource allocation : C/E 20080101

• Thiols oxidation and covalent binding of BSA by cyclolignanic quinones are enhanced by the magnesium cation.

  Free radical research 20080101

• Bag culture: a method for root-root co-culture.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20080101

• Estimation of the incidence of genital warts and the cost of illness in Germany: a cross-sectional study.

  BMC infectious diseases 20080101

• Podophyllotoxin from suspension culture of Linum album.

  Natural product research 20080101

• Concise stereoselective synthesis of (-)-podophyllotoxin by an intermolecular iron(III)-catalyzed Friedel-Crafts alkylation.

  Angewandte Chemie (International ed. in English) 20080101

• Application of cantharidin and podophyllotoxin for the treatment of plantar warts.

  Journal of the American Podiatric Medical Association 20080101

• An experimental and computational study of effects of microtubule stabilization on T-cell polarity.

  PloS one 20080101

• Total excision and V-Y plasty technique in the anal area condyloma acuminatum.

  Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India 20080101

• A review on plant-derived natural products and their analogs with anti-tumor activity.

  Indian journal of pharmacology 20080101

• 3-(2'-Bromopropionylamino)-benzamides as novel S-phase arrest agents.

  Bioorganic & medicinal chemistry letters 20071215

• Pattern analysis of microtubule-polymerizing and -depolymerizing agent combinations as cancer chemotherapies.

  International journal of oncology 20071201

• Reversal of P-glycoprotein-mediated drug efflux by eudesmin from Haplophyllum perforatum and cytotoxicity pattern versus diphyllin, podophyllotoxin and etoposide.

  Planta medica 20071201

• Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

  Journal of medicinal chemistry 20071129

• Synthesis and pharmacological evaluation of fluorescent and photoactivatable analogues of antiplasmodial naphthylisoquinolines.

  Journal of medicinal chemistry 20071129

• Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations.

  Journal of medicinal chemistry 20071115

• Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives.

  Journal of medicinal chemistry 20071115

• Quinuclidine derivatives as potential antiparasitics.

  Antimicrobial agents and chemotherapy 20071101

• Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.

  Bioorganic & medicinal chemistry 20071101

• Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry.

  Bioorganic & medicinal chemistry 20071101

• Frequency, severity and risk factors for oral mucositis after BEAM conditioning and autologous peripheral blood stem cell transplantation: a single center analysis and review of the literature.

  Leukemia & lymphoma 20071101

• Discovery and investigation of antiproliferative and apoptosis-inducing properties of new heterocyclic podophyllotoxin analogues accessible by a one-step multicomponent synthesis.

  Journal of medicinal chemistry 20071018

• Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival.

  International journal of cancer 20071015

• Silenes in organic synthesis: a concise synthesis of (+/-) -epi-picropodophyllin.

  Organic & biomolecular chemistry 20071007

• Rho guanosine 5'-triphosphatases differentially regulate insulin-like growth factor I (IGF-I) receptor-dependent and -independent actions of IGF-II on human trophoblast migration.

  Endocrinology 20071001

• Creatine enhances differentiation of myogenic C2C12 cells by activating both p38 and Akt/PKB pathways.

  American journal of physiology. Cell physiology 20071001

• Primary refractory Hodgkin's lymphoma: outcome after high-dose chemotherapy and autologous SCT and impact of various prognostic factors on overall and event-free survival. A single institution result of 66 patients.

  Bone marrow transplantation 20071001

• Insight into the GTPase activity of tubulin from complexes with stathmin-like domains.

  Biochemistry 20070918

• Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents.

  Bioorganic & medicinal chemistry 20070915

• Synthesis and insecticidal activities of novel derivatives of podophyllotoxin.

  Natural product research 20070901

• Design, synthesis, and biological evaluation of novel spin-labeled derivatives of podophyllotoxin as potential antineoplastic agents. Part XII.

  Natural product research 20070901

• Anti-malarial activity of N6-modified purine analogues.

  Bioorganic & medicinal chemistry 20070815

• Sesquiterpenoids and cytotoxic lignans from the bark of Libocedrus chevalieri.

  Journal of natural products 20070801

• Treatment of ano-genital warts: the effect of an educational event on practitioner choice.

  International journal of STD & AIDS 20070801

• Treatment of molluscum contagiosum: a brief review and discussion of a case successfully treated with adapelene.

  Dermatology online journal 20070713

• Novel potent antimitotic heterocyclic ketones: synthesis, antiproliferative activity, and structure-activity relationships.

  Bioorganic & medicinal chemistry letters 20070701

• GP7 induces internucleosomal DNA fragmentation independent of caspase activation and DNA fragmentation factor in NB4 cells.

  Oncology reports 20070701

• The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling.

  Journal of vascular surgery 20070701

• Secondary acute myelogenous leukemia in patients with retinoblastoma: is chemotherapy a factor?

  Ophthalmology 20070701

• Antioxidative and antitumor activity of derivatives of 4-beta-amino-4'-demethylepipodophyllotoxin and their structure-activity relationship.

  Die Pharmazie 20070601

• Protective efficacy of semi purified fraction of high altitude podophyllum hexandrum rhizomes in lethally irradiated Swiss albino mice.

  Cellular and molecular biology (Noisy-le-Grand, France) 20070530

• Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.

  Journal of medicinal chemistry 20070517

• Aryltetralin-lignan formation in two different cell suspension cultures of Linum album: deoxypodophyllotoxin 6-hydroxylase, a key enzyme for the formation of 6-methoxypodophyllotoxin.

  Phytochemistry 20070501

• A second autologous transplant may be efficacious in selected patients with Hodgkin's lymphoma relapsing after a previous autograft.

  Leukemia & lymphoma 20070501

• [Treatment of recurrent condyloma acuminatum with solid lipid nanoparticle gel containing podophyllotoxin: a randomized double-blinded, controlled clinical trial].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070501

• Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives.

  Bioorganic & medicinal chemistry letters 20070401

• Yttrium-90-ibritumomab tiuxetan (Zevalin) combined with high-dose BEAM chemotherapy and autologous stem cell transplantation for chemo-refractory aggressive non-Hodgkin's lymphoma.

  Experimental hematology 20070401

• Podophyllotoxin content, above- and belowground biomass in relation to altitude in Podophyllum hexandrum populations from Kumaun region of the Indian Central Himalaya.

  Planta medica 20070401

• The contribution of oxazolidinone frame to the biological activity of pharmaceutical drugs and natural products.

  Mini reviews in medicinal chemistry 20070401

• [Transdermal fentanyl in treating severe painful mucositis caused by autologous hematopoietic stem cell transplantation].

  Ai zheng = Aizheng = Chinese journal of cancer 20070401

• The diagnosis and treatment of human papillomavirus-mediated genital lesions.

  Cutis 20070401

• A new and efficient strategy for the synthesis of podophyllotoxin and its analogues.

  Organic letters 20070329

• In the absence of IGF-1 signaling, IFN-gamma suppresses human malignant T-cell growth.

  Blood 20070315

• Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-I receptor.

  Cancer research 20070315

• Structural simplification of bioactive natural products with multicomponent synthesis: dihydropyridopyrazole analogues of podophyllotoxin.

  Bioorganic & medicinal chemistry letters 20070301

• Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents.

  Bioorganic & medicinal chemistry letters 20070301

• Long-term follow-up of endoscopic therapy of anal canal condylomata acuminata with podophyllotoxin.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20070301

• Targeted therapies in adult soft tissue sarcomas.

  Journal of surgical oncology 20070301

• Palifermin and palmar-plantar erythrodysesthesia.

  British journal of haematology 20070301

• Synthesis and cytotoxic evaluation of C-9 oxidized podophyllotoxin derivatives.

  Bioorganic & medicinal chemistry 20070215

• Tandem high-dose chemotherapy and autologous stem cell transplantation in refractory/relapsed Hodgkin's lymphoma: a monocenter prospective study.

  American journal of hematology 20070201

• Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines.

  Journal of natural products 20070201

• Factors influencing engraftment in autologous peripheral hematopoetic stem cell transplantation (PBSCT).

  Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 20070201

• [What is your diagnosis? Neutropenic colitis (neutropenic typhlitis)].

  Praxis 20070124

• Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development.

  Endocrinology 20070101

• Promotion of tubulin assembly by poorly soluble taxol analogs.

  Analytical biochemistry 20070101

• Combination chemotherapy followed by autologous stem cell transplant for enteropathy-associated T cell lymphoma.

  British journal of haematology 20070101

• Two cases of secondary acute myeloid leukemia accompanying adult T-cell leukemia/lymphoma.

  International journal of hematology 20070101

• Control of apoptosis in human multiple myeloma by insulin-like growth factor I (IGF-I).

  Advances in cancer research 20070101

• Root cultures of linum species section Syllinum as rich sources of 6-methoxypodophyllotoxin.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101

• A fragmentation study of podophyllotoxin and its 4'-demethyl-4beta-substituted derivatives by electrospray ionization ion-trap time-of-flight tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20070101

• Induction of apoptosis by alkaloids, non-protein amino acids, and cardiac glycosides in human promyelotic HL-60 cells.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101

• Genital warts treated by photodynamic therapy.

  Skinmed 20070101

• Treatment outcome and cost-effectiveness analysis of two chemotherapeutic regimens (BEP vs. VIP) for poor-prognosis metastatic germ cell tumors.

  Journal of cancer research and therapeutics 20070101

• Warts (genital).

  BMJ clinical evidence 20070101

• The roles of beta-tubulin mutations and isotype expression in acquired drug resistance.

  Cancer informatics 20070101

• 9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

  Journal of medicinal chemistry 20061228

• Dietary antioxidant curcumin inhibits microtubule assembly through tubulin binding.

  The FEBS journal 20061201

• Podophyllum hexandrum Offers Radioprotection by Modulating Free Radical Flux: Role of Aryl-Tetralin Lignans.

  Evidence-based complementary and alternative medicine : eCAM 20061201

• Bioconversion of deoxypodophyllotoxin into epipodophyllotoxin in E. coli using human cytochrome P450 3A4.

  Journal of biotechnology 20061110

• Synthesis and biological evaluation of new 4beta-5-Fu-substituted 4'-demethylepipodophyllotoxin derivatives.

  Molecules (Basel, Switzerland) 20061102

• In vitro antiprotozoal activity of the lipophilic extracts of different parts of Turkish Pistacia vera L.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20061101

• Synthesis and structure-activity relationships of carbazole sulfonamides as a novel class of antimitotic agents against solid tumors.

  Journal of medicinal chemistry 20061019

• Outpatient autologous hematopoietic stem cell transplantation for patients with relapsed follicular lymphoma.

  Annals of hematology 20061001

• Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416.

  Bioorganic & medicinal chemistry 20061001

• Autologous peripheral blood stem cell transplantation for severe multiple sclerosis.

  International journal of hematology 20061001

• Nursing care and treatment of the patient with human papillomavirus.

  British journal of nursing (Mark Allen Publishing) 20061001

• Design and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulin.

  Journal of medicinal chemistry 20060921

• [4-(imidazol-1-yl)thiazol-2-yl]phenylamines. A novel class of highly potent colchicine site binding tubulin inhibitors: synthesis and cytotoxic activity on selected human cancer cell lines.

  Journal of medicinal chemistry 20060921

• IGF-1R tyrosine kinase expression and dependency in clones of IGF-1R knockout cells (R-).

  Biochemical and biophysical research communications 20060908

• Prolonged remission in a case of Richter's transformation of B-cell chronic lymphocytic leukaemia following adoptive immunotherapy.

  Bone marrow transplantation 20060901

• Hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha are expressed in kaposi sarcoma and modulated by insulin-like growth factor-I.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060801

• Endophyte fungal isolates from Podophyllum peltatum produce podophyllotoxin.

  Journal of natural products 20060801

• Synthesis and cytotoxicity of racemic isodeoxypodophyllotoxin analogues with isoprene-derived side chains.

  Journal of natural products 20060801

• Morbidity and transplant-related mortality of CBV and BEAM preparative regimens for patients with lymphoid malignancies undergoing autologous stem-cell transplantation.

  Leukemia & lymphoma 20060801

• Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase.

  Bioorganic & medicinal chemistry letters 20060715

• Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.

  Journal of medicinal chemistry 20060713

• Deoxypodophyllotoxin (DPT) inhibits eosinophil recruitment into the airway and Th2 cytokine expression in an OVA-induced lung inflammation.

  Planta medica 20060701

• Frequency and timing of leaf removal affect growth and podophyllotoxin content of Podophyllum peltatum in full sun.

  Planta medica 20060701

• Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.

  Journal of medicinal chemistry 20060629

• Upfront double high-dose chemotherapy with DICEP followed by BEAM and autologous stem cell transplantation for poor-prognosis aggressive non-Hodgkin lymphoma.

  Blood 20060615

• Molecular identification of Sinopodophyllum hexandrum and Dysosma species using cpDNA sequences and PCR-RFLP markers.

  Planta medica 20060601

• Medicinal chemistry approaches to target the kinase activity of IGF-1R.

  IDrugs : the investigational drugs journal 20060601

• Palifermin for oral mucositis in the high-dose chemotherapy and stem cell transplant setting: the Royal Adelaide Hospital Cancer Centre experience.

  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20060601

• Genital warts.

  Clinical evidence 20060601

• Recent patents therapeutic agents for cancer.

  Recent patents on anti-cancer drug discovery 20060601

• The insulin-like growth factor-1 receptor inhibitor PPP produces only very limited resistance in tumor cells exposed to long-term selection.

  Oncogene 20060525

• Oxalone and lactone moieties of podophyllotoxin exhibit properties of both the B and C rings of colchicine in its binding with tubulin.

  Biochemistry 20060523

• Synthesis and biological evaluation of new spin-labeled derivatives of podophyllotoxin.

  Bioorganic & medicinal chemistry 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Randomised phase III study of R-ICE versus R-DHAP in relapsed patients with CD20 diffuse large B-cell lymphoma (DLBCL) followed by high-dose therapy and a second randomisation to maintenance treatment with rituximab or not: an update of the CORAL study.

  Annals of oncology : official journal of the European Society for Medical Oncology 20060501

• Successful autologous hematopoietic stem cell transplantations for severe multiple sclerosis with fludarabine and cyclophosphamide conditioning.

  International journal of hematology 20060501

• [Studies on the interaction of the metal complex of hydrazide of podophyllic acid with DNA].

  Guang pu xue yu guang pu fen xi = Guang pu 20060501

• [Study on extraction methods of activity components from Podophyllum emodi wall].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060501

• The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllotoxin and related aryl tetralin lignans.

  Journal of biotechnology 20060420

• Benzoylphenylurea sulfur analogues with potent antitumor activity.

  Journal of medicinal chemistry 20060406

• Incidence and clinical relevance of abnormal complete blood counts in long-term survivors of childhood cancer.

  Cancer 20060401

• Evaluation of cytotoxic potential of latex of Calotropis procera and podophyllotoxin in Allium cepa root model.

  Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20060401

• Thiocolchicine-podophyllotoxin conjugates: dynamic libraries based on disulfide exchange reaction.

  The Journal of organic chemistry 20060331

• An evidence-based review of medical and surgical treatments of genital warts.

  Dermatology online journal 20060330

• Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum.

  Organic & biomolecular chemistry 20060307

• Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents.

  Bioorganic & medicinal chemistry letters 20060301

• Efficacy of diverse high-dose regimens followed by autologous peripheral blood stem cell transplantation in consecutive multiple myeloma patients: a single-centre analysis over a 12-year period.

  Annals of hematology 20060301

• Immunology and homeopathy. 2. Cells of the immune system and inflammation.

  Evidence-based complementary and alternative medicine : eCAM 20060301

• The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060215

• Successful autologous peripheral blood stem cell harvest and transplant in a patient with cold agglutinins.

  Bone marrow transplantation 20060201

• Protection of the hemopoietic system by Podophyllum hexandrum against gamma radiation-induced damage.

  Planta medica 20060201

• Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.

  Blood 20060115

• IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.

  Blood 20060115

• Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting.

  Journal of controlled release : official journal of the Controlled Release Society 20060110

• Trial of amifostine in autologous stem cell transplant.

  Bone marrow transplantation 20060101

• Correlations between the activities of 19 anti-tumor agents and the intracellular glutathione concentrations in a panel of 14 human cancer cell lines: comparisons with the National Cancer Institute data.

  Anti-cancer drugs 20060101

• L-carnitine inhibits apoptotic DNA fragmentation induced by a new spin-labeled derivative of podophyllotoxin via caspase-3 in Raji cells.

  Oncology reports 20060101

• Prophylaxis of central venous catheter-related thrombosis with minidose warfarin in patients treated with high-dose chemotherapy and peripheral-blood stem-cell transplantation: retrospective analysis of 228 cancer patients.

  American journal of hematology 20060101

• Isoflavonoids and other compounds from Psorothamnus arborescens with antiprotozoal activities.

  Journal of natural products 20060101

• Camptothecin and podophyllotoxin derivatives: inhibitors of topoisomerase I and II - mechanisms of action, pharmacokinetics and toxicity profile.

  Drug safety 20060101

• [Studies on antitumor effects of podophyllotoxin nanoliposome].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060101

• Aspects of early arthritis. Traditional DMARD therapy: is it sufficient?

  Arthritis research & therapy 20060101

• Characterization of two epimers, 4alpha and 4beta, of a novel podophyllotoxin-4-O-(D)-6-acetylglucopyranoside from Podophyllum hexandrum by LC-ESI-MS-MS.

  Journal of chromatographic science 20060101

• Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel.

  Beilstein journal of organic chemistry 20060101

• Topoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma.

  World journal of surgical oncology 20060101

• Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.

  Molecular neurodegeneration 20060101

• Meta-analysis of 5% imiquimod and 0.5% podophyllotoxin in the treatment of condylomata acuminata.

  Dermatology (Basel, Switzerland) 20060101

• Taxane-resistant lymphoepithelial-like carcinoma: excellent response to VIP chemotherapy.

  Irish journal of medical science 20060101

• Deoxypodophyllotoxin content and antioxidant activity of aerial parts of Anthriscus sylvestris Hoffm.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101

• Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.

  Bioorganic & medicinal chemistry letters 20051215

• Randomized controlled trial of an adjuvanted human papillomavirus (HPV) type 6 L2E7 vaccine: infection of external anogenital warts with multiple HPV types and failure of therapeutic vaccination.

  The Journal of infectious diseases 20051215

• Bioactive constituents from roots of Bursera tonkinensis.

  Phytochemistry 20051201

• Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate.

  Journal of medicinal chemistry 20051117

• Synthesis and biological evaluation of new 4beta-anilino- and 4beta-imido-substituted podophyllotoxin congeners.

  Bioorganic & medicinal chemistry 20051115

• Discovery of novel immunostimulants by dendritic-cell-based functional screening.

  Blood 20051101

• Methyltrioxorhenium catalysed synthesis of highly oxidised aryltetralin lignans with anti-topoisomerase II and apoptogenic activities.

  Bioorganic & medicinal chemistry 20051101

• Plant-based anticancer molecules: a chemical and biological profile of some important leads.

  Bioorganic & medicinal chemistry 20051101

• Enhancement of lignan biosynthesis in suspension cultures of Linum nodiflorum by coronalon, indanoyl-isoleucine and methyl jasmonate.

  Planta 20051101

• Development of an enzyme-linked immunosorbent assay for podophyllotoxin.

  International immunopharmacology 20051001

• Ifosfamide, epirubicin, etoposide (IEV) and autologous peripheral blood progenitor cell transplant: a feasible and effective salvage treatment for lymphoid malignancies.

  Oncology reports 20051001

• A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach.

  Journal of medicinal chemistry 20050922

• Florid cutaneous papillomatosis leading to social exclusion.

  The British journal of dermatology 20050901

• Chemotherapy-induced hypersensitivity reactions.

  Oncology nursing forum 20050901

• Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles.

  British journal of cancer 20050822

• Apoptosis induced by one new podophyllotoxin glucoside in human carcinoma cells.

  Toxicology 20050815

• Cytotoxicity, apoptosis induction, and mitotic arrest by a novel podophyllotoxin glucoside, 4DPG, in tumor cells.

  Acta pharmacologica Sinica 20050801

• Influence of methyl jasmonate on podophyllotoxin and 6-methoxypodophyllotoxin accumulation in Linum album cell suspension cultures.

  Plant cell reports 20050701

• A phase Ib clinical trial of PV701, a milk-derived protein extract, for the prevention and treatment of oral mucositis in patients undergoing high-dose BEAM chemotherapy.

  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20050701

• Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050701

• Pinoresinol-lariciresinol reductases with different stereospecificity from Linum album and Linum usitatissimum.

  Phytochemistry 20050601

• Prediction of genotoxicity of chemical compounds by statistical learning methods.

  Chemical research in toxicology 20050601

• Genital warts.

  Clinical evidence 20050601

• Synthesis and identification of antigenic conjugates of podophyllotoxin.

  Yao xue xue bao = Acta pharmaceutica Sinica 20050601

• Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound.

  Journal of natural products 20050501

• Synthesis and biological activity of new class of dioxygenated anticancer agents.

  Current medicinal chemistry. Anti-cancer agents 20050501

• Insulin-like growth factor-I receptor activity is essential for Kaposi's sarcoma growth and survival.

  British journal of cancer 20050425

• Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans.

  The Journal of biological chemistry 20050401

• Synthesis and in vitro cytotoxic activity of N-, F-, and S-ether derivatives of podophyllotoxin fatty acid adducts.

  Lipids 20050401

• Novel carbamate derivatives of 4-beta-amino-4'-O-demethyl-4-desoxypodophyllotoxin as inhibitors of topoisomerase II: synthesis and biological evaluation.

  Organic & biomolecular chemistry 20050321

• Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life.

  Blood 20050315

• Toxicity of the topoisomerase II inhibitors.

  Expert opinion on drug safety 20050301

• A cross-sectional survey of treatment choices for anogenital warts.

  International journal of STD & AIDS 20050301

• Anticancer activity and possible mode of action of 4-O-podophyllotoxinyl 12-hydroxyl-octadec-Z-9-enoate.

  Lipids 20050301

• [An experimental study on proliferative effects and apoptotic effects of podophyllic acid in K562 cells].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050201

• Synthesis and biological study of a new series of 4'-demethylepipodophyllotoxin derivatives.

  Journal of medicinal chemistry 20050127

• [Preparation of stearic acid solid lipid nanoparticles containing podophyllotoxin].

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050101

• [4-Aza-2,3-didehydropodophyllotoxins: new lignan with antitumor activity obtained from one-step synthesis].

  Annales pharmaceutiques francaises 20050101

• Condyloma with lichen nitidus.

  Skinmed 20050101

• Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents.

  Current pharmaceutical design 20050101

• Linum mucronatum: organ to organ lignan variations.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101

• Genital warts: current and future management options.

  American journal of clinical dermatology 20050101

• Grade 3 vulvar and anal intraepithelial neoplasia in a HIV seropositive child--therapeutic result: case report.

  Clinical and experimental obstetrics & gynecology 20050101

• Cytotoxic activity of a podophyllotoxin-like lignan from Linum tauricum Willd.

  Neoplasma 20050101

• ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal.

  Cancer cell international 20050101

• Genital infection with human papillomavirus in adolescents.

  Advances in therapy 20050101

• Human papillomavirus: burden of illness and treatment cost considerations.

  American journal of clinical dermatology 20050101

• Radioprotective and antioxidant properties of low-altitude Podophyllum hexandrum (LAPH).

  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20050101

• Management of genital warts.

  American family physician 20041215

• Microtubulin binding sites as target for developing anticancer agents.

  Mini reviews in medicinal chemistry 20041201

• Lignan accumulation in cell cultures of Linum strictum ssp. strictum L.

  Acta pharmaceutica (Zagreb, Croatia) 20041201

• Pearly penile lesions.

  The Journal of family practice 20041101

• Insecticidal activity of deoxypodophyllotoxin, isolated from Juniperus sabina L, and related lignans against larvae of Pieris rapae L.

  Pest management science 20041101

• Synthesis and cytotoxic activity of novel derivatives of 4'-demethylepipodophyllotoxin.

  Bioorganic & medicinal chemistry letters 20041018

• The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway.

  Oncogene 20041014

• Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives.

  Journal of medicinal chemistry 20041007

• High-dose CEB vs BEAM with autologous stem cell transplant in lymphoma.

  Bone marrow transplantation 20041001

• Low-dose oral etoposide-based induction regimen for children with acute lymphoblastic leukemia in first bone marrow relapse.

  Leukemia 20041001

• Biotechnological aspects of the production of the anticancer drug podophyllotoxin.

  Applied microbiology and biotechnology 20041001

• Lignoids in insects: chemical probes for the study of ecdysis, excretion and Trypanosoma cruzi-triatomine interactions.

  Toxicon : official journal of the International Society on Toxinology 20040915

• Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives.

  Toxicon : official journal of the International Society on Toxinology 20040915

• Mass spectrometric measurement of differential reactivity of cysteine to localize protein-ligand binding sites. Application to tubulin-binding drugs.

  Analytical biochemistry 20040915

• Design, synthesis, biological evaluation and QSAR studies of novel bisepipodophyllotoxins as cytotoxic agents.

  Bioorganic & medicinal chemistry 20040801

• Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives.

  Bioorganic & medicinal chemistry 20040801

• Remission of acute monocytic leukemia, secondary to treatment with epipodophyllotoxins, in a patient with t(8;16)(p11;p13) and MYST3-CREBBP fusion.

  Cancer genetics and cytogenetics 20040715

• Roles of NF-kappaB and SP-1 in oxidative stress-mediated induction of platelet-derived growth factor-B by TNFalpha in human endothelial cells.

  Journal of cardiovascular pharmacology 20040701

• [Preparation and characterization of podophyllotoxin-dipalmitoylphosphatidylcholine proliposome].

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20040701

• Synthesis, spectroscopic, and biological studies of novel estolides derived from anticancer active 4-O-podophyllotoxinyl 12-hydroxyl-octadec-Z-9-enoate.

  Lipids 20040701

• Antitumor agents. Part 227: Studies on novel 4'-O-demethyl-epipodophyllotoxins as antitumor agents targeting topoisomerase II.

  Bioorganic & medicinal chemistry 20040615

• Critical appraisal of commonly used treatment for genital warts.

  International journal of STD & AIDS 20040601

• Dual inhibition of cyclooxygenases-2 and 5-lipoxygenase by deoxypodophyllotoxin in mouse bone marrow-derived mast cells.

  Biological & pharmaceutical bulletin 20040601

• Comparison of different extraction methods for the determination of podophyllotoxin and 6-methoxypodophyllotoxin in Linum species.

  Journal of pharmaceutical and biomedical analysis 20040528

• A quantitative evaluation of the effects of inhibitors of tubulin assembly on polymerization induced by discodermolide, epothilone B, and paclitaxel.

  Cancer chemotherapy and pharmacology 20040501

• Patient assessment of anogenital warts and the success of treatment with home applied therapy.

  International journal of STD & AIDS 20040501

• Effects of microtubule-depolymerizing agents on the transfection of cultured vascular smooth muscle cells: enhanced expression with free drug and especially with drug-gene lipoplexes.

  Molecular therapy : the journal of the American Society of Gene Therapy 20040501

• Deoxypodophyllotoxin, a naturally occurring lignan, inhibits the passive cutaneous anaphylaxis reaction.

  Planta medica 20040501

• A novel podophyllotoxin lignan from Justicia heterocarpa.

  Chemical & pharmaceutical bulletin 20040501

• Synthesis and biological activity of sulfonamide derivatives of epipodophyllotoxin.

  Journal of medicinal chemistry 20040422

• alphaB-Crystallin-coated MAP microtubule resists nocodazole and calcium-induced disassembly.

  Journal of cell science 20040401

• [Preparation of liposome podophyllotoxin chitosan film and determination the podophyllotoxin content in the film by ultraviolet spectrophotometry].

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20040401

• Deoxypodophyllotoxin reduces skin pigmentation of brown Guinea pigs.

  Planta medica 20040401

• New chromanone acids with antibacterial activity from Calophyllum brasiliense.

  Journal of natural products 20040401

• Alpha-conidendrin as a source for preparation of sikkimotoxin derivatives.

  Journal of natural products 20040401

• Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents.

  Bioorganic & medicinal chemistry letters 20040322

• Synthesis and cytotoxicity of hydrophobic esters of podophyllotoxins.

  Bioorganic & medicinal chemistry letters 20040308

• Synthesis and biological evaluation of new selective cytotoxic cyclolignans derived from podophyllotoxin.

  Journal of medicinal chemistry 20040226

• Sexually transmissible infections other than HIV.

  Lancet (London, England) 20040214

• Cytotoxicity of in vitro produced podophyllotoxin from Podophyllum hexandrum on human cancer cell line.

  Natural product research 20040201

• Antineoplastic agents. 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives).

  Journal of natural products 20040201

• Alkyl and carboxylalkyl esters of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxic, and antitumor activity.

  European journal of medicinal chemistry 20040201

• Synthesis and anticancer activities of fatty acid analogs of podophyllotoxin.

  Lipids 20040201

• A concise stereocontrolled formal total synthesis of (+/-)-podophyllotoxin using sulfoxide chemistry.

  Chemical communications (Cambridge, England) 20040121

• GP7 can induce apoptotic DNA fragmentation of human leukemia cells through caspase-3-dependent and -independent pathways.

  International journal of molecular medicine 20040101

• Pharmacokinetic optimisation of treatment with oral etoposide.

  Clinical pharmacokinetics 20040101

• Radioprotective effect of podophyllotoxin in Saccharomyces cerevisiae.

  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20040101

• Analysis of neutral drugs in human plasma by fluoride attachment in liquid chromatography/negative ion electrospray tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20040101

• Therapy of cutaneous human Papillomavirus infections.

  Dermatologic therapy 20040101

• [The multidrug tumor cell resistance phenotype caused by the impaired cell death program].

  Vestnik Rossiiskoi akademii meditsinskikh nauk 20040101

• [Autologous stem-cell transplantations in children with non-Hodgkin lymphomas].

  Przeglad lekarski 20040101

• Human papillomavirus infections: diagnosis, treatment, and hope for a vaccine.

  Obstetrics and gynecology clinics of North America 20031201

• Synthesis of 4beta-amido and 4beta-sulphonamido analogues of podophyllotoxin as potential antitumour agents.

  Bioorganic & medicinal chemistry 20031117

• LAV694, a new antiproliferative agent showing improved skin tolerability vs. clinical standards for the treatment of actinic keratosis.

  Biochemical pharmacology 20031115

• Extensive condyloma acuminata treated with imiquimod 5% cream: a case report.

  Clinical and experimental dermatology 20031101

• The intramolecular carboxyarylation approach to podophyllotoxin.

  Journal of the American Chemical Society 20031008

• Synthesis, cytotoxicity and antiviral activity of podophyllotoxin analogues modified in the E-ring.

  European journal of medicinal chemistry 20031001

• [Human papillomaviruses].

  Therapeutische Umschau. Revue therapeutique 20031001

• Beta-peltatin 6-O-methyltransferase from suspension cultures of Linum nodiflorum.

  Phytochemistry 20030901

• Enhancement of radiation-induced apoptosis by Podophyllum hexandrum.

  The Journal of pharmacy and pharmacology 20030901

• Antitumor activity of unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin.

  Bioorganic & medicinal chemistry letters 20030818

• A mathematical model for reconstitution of granulopoiesis after high dose chemotherapy with autologous stem cell transplantation.

  Journal of mathematical biology 20030801

• Randomised controlled trial and economic evaluation of podophyllotoxin solution, podophyllotoxin cream, and podophyllin in the treatment of genital warts.

  Sexually transmitted infections 20030801

• A phytochemical study of lignans in whole plants and cell suspension cultures of Anthriscus sylvestris.

  Planta medica 20030801

• The bioconversion process of deoxypodophyllotoxin with Linum flavum cell cultures.

  Planta medica 20030801

• The tumor suppressor interferon regulatory factor 1 interferes with SP1 activation to repress the human CDK2 promoter.

  The Journal of biological chemistry 20030718

• Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

  Journal of medicinal chemistry 20030717

• In vitro cytotoxicity of aplidin and crossresistance with other cytotoxic drugs in childhood leukemic and normal bone marrow and blood samples: a rational basis for clinical development.

  Leukemia 20030701

• Biotransformation of a dibenzylbutanolide to podophyllotoxin analogues by shoot cultures of Haplophyllum patavinum.

  Chemical & pharmaceutical bulletin 20030701

• BEAC or BEAM for high-dose therapy in patients with non-Hodgkin's lymphoma? A single centre analysis on toxicity and efficacy.

  Leukemia & lymphoma 20030701

• Efficient enantioselective total synthesis of (-)-epipodophyllotoxin.

  Angewandte Chemie (International ed. in English) 20030606

• Cytotoxic and cytostatic activity of erlangerins from Commiphora erlangeriana.

  Toxicon : official journal of the International Society on Toxinology 20030501

• A hybrid form of myeloid/NK-cell acute leukemia and myeloid/NK-cell precursor acute leukemia.

  Human pathology 20030501

• Variation of podophyllotoxin in leaves of Eastern Red Cedar (Juniperus virginiana).

  Planta medica 20030501

• Bioactivity of secoiridoid glycosides from Centaurium erythraea.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20030501

• [Therapy-related acute leukaemia and myelodysplastic syndrome].

  Anales de medicina interna (Madrid, Spain : 1984) 20030501

• Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A.

  Journal of medicinal chemistry 20030424

• Transcription factor IID recruitment and Sp1 activation. Dual function of TAF1 in cyclin D1 transcription.

  The Journal of biological chemistry 20030411

• The cost-effectiveness of patient-applied treatments for anogenital warts.

  International journal of STD & AIDS 20030401

• Er:YAG laser followed by topical podophyllotoxin for hard-to-treat palmoplantar warts.

  Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology 20030401

• Modes of methyleneoxy bridging and their effect on tetrahydronaphthalene lignan cytotoxicity.

  Journal of medicinal chemistry 20030327

• Podophyllum peltatum possesses a beta-glucosidase with high substrate specificity for the aryltetralin lignan podophyllotoxin.

  Biochimica et biophysica acta 20030321

• Dearomatizing cyclization of arylsulfonylalkoxymethyl lithiums: a route to the podophyllotoxin skeleton.

  Organic letters 20030320

• [Bacteremia due to Capnocytophaga spp.: two cases].

  Enfermedades infecciosas y microbiologia clinica 20030301

• Preparation and comparative analysis of two podophyllotoxin liposomes.

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030301

• Naphthalene analogues of lignans.

  The Journal of organic chemistry 20030207

• Algicidal activity and gliding motility of Saprospira sp. SS98-5.

  Canadian journal of microbiology 20030201

• Effect of a novel somatostatin analogue combined with cytotoxic drugs on human tumour xenografts and metastasis of B16 melanoma.

  British journal of cancer 20030113

• High-dose therapy in diffuse large cell lymphoma: results and prognostic factors in 452 patients from the GEL-TAMO Spanish Cooperative Group.

  Annals of oncology : official journal of the European Society for Medical Oncology 20030101

• Effect of major nutrients on podophyllotoxin production in Podophyllum hexandrum suspension cultures.

  Applied microbiology and biotechnology 20030101

• Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring.

  European journal of medicinal chemistry 20030101

• Taxanes in the treatment of advanced (stage III and IV) non-small cell lung cancer (NSCLC): recent developments.

  Cancer investigation 20030101

• Late effects of treatment for cancer during childhood and adolescence.

  Current problems in cancer 20030101

• Enhanced production of podophyllotoxin by Podophyllum hexandrum using in situ cell retention bioreactor.

  Biotechnology progress 20030101

• CPH 82.

  BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20030101

• Production of podophyllotoxin using cross-species coculture of Linum flavum hairy roots and Podophyllum hexandrum cell suspensions.

  Biotechnology progress 20030101

• [A model-based comparison of cost effectiveness of imiquimod versus podophyllotoxin for the treatment of external anogenital warts in France].

  Annales de dermatologie et de venereologie 20030101

• Pervilleine F, a new tropane alkaloid aromatic ester that reverses multidrug resistance.

  Anticancer research 20030101

• An epiisopicropodophyllin aza analogue via palladium-catalyzed pseudo-domino cyclization.

  The Journal of organic chemistry 20021227

• Chemoresistant or aggressive lymphoma predicts for a poor outcome following reduced-intensity allogeneic progenitor cell transplantation: an analysis from the Lymphoma Working Party of the European Group for Blood and Bone Marrow Transplantation.

  Blood 20021215

• Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity.

  Bioorganic & medicinal chemistry letters 20021202

• Hemi-synthesis and biological activity of new analogues of podophyllotoxin.

  Bioorganic & medicinal chemistry 20021101

• Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.

  Journal of natural products 20021101

• External genital warts: diagnosis, treatment, and prevention.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021015

• Meiotic telomere clustering is inhibited by colchicine but does not require cytoplasmic microtubules.

  Journal of cell science 20021001

• Methamphetamine activates DNA binding of specific redox-responsive transcription factors in mouse brain.

  Journal of neuroscience research 20021001

• Biosynthesis of podophyllotoxin in Linum album cell cultures.

  Planta 20021001

• Experimental study of podophyllotoxin dipalmitoylphosphatidylcholine liposome for topical skin application.

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20021001

• Zinc enhances the expression of interleukin-2 and interleukin-2 receptors in HUT-78 cells by way of NF-kappaB activation.

  The Journal of laboratory and clinical medicine 20021001

• Assessment of the antiprotozoal activity of Galphimia glauca and the isolation of new nor-secofriedelanes and nor-friedelanes.

  Journal of natural products 20021001

• A multicomponent reaction for the one-pot synthesis of 4-aza-2,3-didehydropodophyllotoxin and derivatives.

  Organic letters 20020919

• Cytogenetic analysis of giant oocytes and zygotes to assess their relevance for the development of digynic triploidy.

  Human reproduction (Oxford, England) 20020901

• [Changes in serum concentration of podophyllotoxin after its topical application with liposome on rat skin].

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20020901

• Four lignans from Commiphora erlangeriana.

  Journal of natural products 20020901

• Antioxidative activity of spin labeled derivatives of podophyllic acid hydrazide.

  Acta pharmacologica Sinica 20020801

• Biological activity of 4-acetyltropolone, the minor component of Thujopsis dolabrata SIeb. et Zucc. hondai Mak.

  Biological & pharmaceutical bulletin 20020801

• [Poisoning with a podophyllin-containing wart-treating tincture].

  Deutsche medizinische Wochenschrift (1946) 20020712

• Unusual implantation site of a port-a-cath system via the right femoral vein.

  Journal of cancer research and clinical oncology 20020701

• Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and X-ray crystal structure of normelicopicine.

  Journal of natural products 20020701

• A unique type II topoisomerase mutant that is hypersensitive to a broad range of cleavage-inducing antitumor agents.

  Biochemistry 20020625

• Microtubule damaging agents induce apoptosis in HL 60 cells and G2/M cell cycle arrest in HT 29 cells.

  Toxicology 20020614

• Flow cytometric estimation on cytotoxic activity of leaf extracts from seashore plants in subtropical Japan: isolation, quantification and cytotoxic action of (-)-deoxypodophyllotoxin.

  Phytotherapy research : PTR 20020601

• Effect of the DNA topoisomerase II inhibitor VP-16 on illegitimate recombination in yeast chromosomes.

  Gene 20020529

• Antitumor agents. 213. Modeling of epipodophyllotoxin derivatives using variable selection k nearest neighbor QSAR method.

  Journal of medicinal chemistry 20020523

• A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs.

  British journal of cancer 20020520

• Antitumor and antioxidant activity of spin labeled derivatives of podophyllotoxin (GP-1) and congeners.

  Life sciences 20020405

• Facial molluscum: treatment with cryotherapy and podophyllotoxin.

  International journal of STD & AIDS 20020401

• Clinical inquiries. What is the most effective treatment for external genital warts?

  The Journal of family practice 20020401

• Evaluation of Podophyllum peltatum accessions for podophyllotoxin production.

  Planta medica 20020401

• Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex.

  Oncogene 20020314

• Synthesis and insecticidal activity of novel 4beta-halogenated benzoylamino podophyllotoxins against Pieris rapae Linnaeus.

  Chemical & pharmaceutical bulletin 20020301

• Deoxypodophyllotoxin; the cytotoxic and antiangiogenic component from Pulsatilla koreana.

  Planta medica 20020301

• Human T-cell leukemia virus type I Tax transactivates the matrix metalloproteinase-9 gene: potential role in mediating adult T-cell leukemia invasiveness.

  Blood 20020215

• Positron emission tomography with [18F]2-fluoro-D-2-deoxyglucose (FDG-PET) predicts relapse of malignant lymphoma after high-dose therapy with stem cell transplantation.

  Leukemia 20020201

• Treatment of non-Hodgkin's lymphoma in the elderly. The Italian studies.

  Tumori 20020101

• Differential modulation by estradiol of P-glycoprotein drug resistance protein expression in cultured MCF7 and T47D breast cancer cells.

  Anticancer research 20020101

• Optimization of culture parameters for production of podophyllotoxin in suspension culture of Podophyllum hexandrum.

  Applied biochemistry and biotechnology 20020101

• [Incidence and management of condylomata acuminata by French general physicians].

  Annales de dermatologie et de venereologie 20020101

• [Management of external genital warts by dermatologists: a French survey].

  Annales de dermatologie et de venereologie 20020101

• [External anogenital condylomas].

  Annales de dermatologie et de venereologie 20020101

• Minimising the long-term adverse effects of childhood leukaemia therapy.

  Drug safety 20020101

• [High-dose chemotherapy with autologous bone marrow transplantation in children with high-risk malignant neoformations].

  Voprosy onkologii 20020101

• Identification of a novel variant of the human NR2B gene promoter region and its possible association with schizophrenia.

  Molecular psychiatry 20020101

• Analysis of the transcriptional regulation of mouse prostacyclin synthase gene.

  Advances in experimental medicine and biology 20020101

• Drugs that inhibit tubulin polymerization: the particular case of podophyllotoxin and analogues.

  Current medicinal chemistry. Anti-cancer agents 20020101

• Production of podophyllotoxin by plant cell cultures of Podophyllum hexandrum in bioreactor.

  Journal of bioscience and bioengineering 20020101

• Podophyllin office therapy against condyloma should be abandoned.

  Sexually transmitted infections 20011201

• A fast and simple GC MS method for lignan profiling in Anthriscus sylvestris and biosynthetically related Plant species.

  Planta medica 20011201

• Factors involved in clearance of genital warts.

  International journal of STD & AIDS 20011201

• The successful treatment of molluscum contagiosum with podophyllotoxin (0.5%) self-application.

  International journal of STD & AIDS 20011201

• Deoxypodophyllotoxin 6-hydroxylase, a cytochrome P450 monooxygenase from cell cultures of Linum flavum involved in the biosynthesis of cytotoxic lignans.

  Planta 20011201

• Consolidation therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of cytosine arabinoside, epipodophyllotoxins and cyclophosphamide.

  Cancer treatment reviews 20011201

• Linker length in podophyllotoxin-acridine conjugates determines potency in vivo and in vitro as well as specificity against MDR cell lines.

  Anti-cancer drug design 20011201

• Analytical approaches for traditional chinese medicines exhibiting antineoplastic activity.

  Journal of chromatography. B, Biomedical sciences and applications 20011125

• Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents.

  Journal of medicinal chemistry 20011108

• Antitumor agents 210. Synthesis and evaluation of taxoid-epipodophyllotoxin conjugates as novel cytotoxic agents.

  Bioorganic & medicinal chemistry 20011101

• Cytogenetic analysis of human zygotes displaying three pronuclei and one polar body after intracytoplasmic sperm injection.

  Human reproduction (Oxford, England) 20011101

• Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine.

  Bioorganic & medicinal chemistry letters 20011008

• Advances in cancer therapy with plant based natural products.

  Current medicinal chemistry 20011001

• Considerations in the selection of an appropriate conditioning regimen for the treatment of rheumatoid arthritis by autologous peripheral blood stem cell transplantation.

  The Journal of rheumatology. Supplement 20011001

• Immunomodulation of early engrafted natural killer cells with interleukin-2 and interferon-alpha in autologous stem cell transplantation.

  Bone marrow transplantation 20011001

• Second malignancy after treatment of childhood non-Hodgkin lymphoma.

  Cancer 20011001

• Silencer activity of NFATc2 in the interleukin-12 receptor beta 2 proximal promoter in human T helper cells.

  The Journal of biological chemistry 20010914

• Aryltetralin lignans: chemistry, pharmacology and biotransformations.

  Current medicinal chemistry 20010901

• Design, synthesis, and biological evaluation of a series of simple and novel potential antimalarial compounds.

  Bioorganic & medicinal chemistry letters 20010723

• [PAPP-A in the first trimester of pregnancy].

  Ceska gynekologie 20010701

• TNF-alpha downregulates murine hepatic growth hormone receptor expression by inhibiting Sp1 and Sp3 binding.

  The Journal of clinical investigation 20010601

• Two new podophyllotoxin glucosides from Sinopodophyllum emodi (Wall.) Ying.

  Chemical & pharmaceutical bulletin 20010601

• New prenylated bi- and tricyclic phloroglucinol derivatives from Hypericum papuanum.

  Journal of natural products 20010601

• A novel topoisomerase II poison GL331 preferentially induces DNA cleavage at (C/G)T sites and can cause telomere DNA damage.

  Pharmaceutical research 20010601

• [Determination of podophyllotoxin lignans in Dysosma and its allied plants].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20010601

• A pancreatic beta -cell-specific enhancer in the human PDX-1 gene is regulated by hepatocyte nuclear factor 3beta (HNF-3beta ), HNF-1alpha, and SPs transcription factors.

  The Journal of biological chemistry 20010518

• Contact dermatitis from topical antiviral drugs.

  Contact dermatitis 20010501

• Pharmacological basis for cladribine resistance in a human acute T lymphoblastic leukaemia cell line selected for resistance to etoposide.

  British journal of haematology 20010501

• Antitumor agents. 207. Design, synthesis, and biological testing of 4beta-anilino-2-fluoro-4'-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents.

  Journal of medicinal chemistry 20010426

• Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection.

  The Journal of biological chemistry 20010420

• A phase I study in paediatric patients to evaluate the safety and pharmacokinetics of SPI-77, a liposome encapsulated formulation of cisplatin.

  British journal of cancer 20010401

• Long-term follow-up in patients treated with Mini-BEAM as salvage therapy for relapsed or refractory Hodgkin's disease.

  British journal of haematology 20010401

• Condyloma eradication: self-therapy with 0.15-0.5% podophyllotoxin versus 20-25% podophyllin preparations--an integrated safety assessment.

  Regulatory toxicology and pharmacology : RTP 20010401

• Cytotoxic cyclolignans related to podophyllotoxin.

  Farmaco (Societa chimica italiana : 1989) 20010401

• Antitumor agents. Synthesis and biological evaluation of new compounds related to podophyllotoxin, containing the 2,3-dihydro-1,4-benzodioxin system.

  European journal of medicinal chemistry 20010401

• Direct medical costs for surgical and medical treatment of condylomata acuminata.

  Archives of dermatology 20010301

• The production of cytotoxic lignans by plant cell cultures.

  Applied microbiology and biotechnology 20010301

• High yield of podophyllotoxin from leaves of Podophyllum peltatum by in situ conversion of podophyllotoxin 4- O-beta-D-glucopyranoside.

  Planta medica 20010201

• Podophyllotoxin lignans enhance IL-1beta but suppress TNF-alpha mRNA expression in LPS-treated monocytes.

  Immunopharmacology and immunotoxicology 20010201

• The treatment of anogenital warts at home.

  Nursing times 20010201

• [Synthesis and activities of 4-deoxy-4 beta-arylmehtylene sulfonylamido-4'-demethylpodophyllotoxins].

  Yao xue xue bao = Acta pharmaceutica Sinica 20010201

• Cytotoxic responses to aromatic ring and configurational variations in alpha-conidendrin, podophyllotoxin, and sikkimotoxin derivatives.

  Journal of medicinal chemistry 20010118

• GATA-4 and serum response factor regulate transcription of the muscle-specific carnitine palmitoyltransferase I beta in rat heart.

  The Journal of biological chemistry 20010112

• [Clinical aspects and therapy of anogenital warts and papillomavirus-associated lesions].

  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20010101

• Issues and practicalities of treating genital warts in the community. Proceedings of a round table meeting facilitated by Succinct Communications Limited.

  International journal of STD & AIDS 20010101

• Imiquimod for the treatment of genital warts: a quantitative systematic review.

  BMC infectious diseases 20010101

• Prevention and management of antineoplastic-induced hypersensitivity reactions.

  Drug safety 20010101

• Management of anogenital warts (condylomata acuminata).

  European journal of dermatology : EJD 20010101

• Treatment of anogenital warts in children with topical 0.05% podofilox gel and 5% imiquimod cream.

  Pediatric dermatology 20010101

• [Myelotoxicity of a plant cytostatic preparation etoposide].

  Eksperimental'naia i klinicheskaia farmakologiia 20010101

• Enhanced podophyllotoxin production from Agrobacterium rhizogenes transformed cultures of Podophyllum hexandrum.

  Natural product letters 20010101

• Accumulation of lignans in suspension cultures of Linum mucronatum ssp. armenum (Bordz.) Davis.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20010101

• Communication challenges in a young man with Hodgkin's disease.

  Cancer practice 20010101

• 6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

  Journal of medicinal chemistry 20001116

• TEL/AML1 gene fusion is related to in vitro drug sensitivity for L-asparaginase in childhood acute lymphoblastic leukemia.

  Blood 20000801

• Podophyllotoxin.

  Phytochemistry 20000501

• Sensory neuropathy due to Bajiaolian (Podophyllotoxin) intoxication.

  European neurology 20000101

• Inhibitory effects of podophyllotoxin derivatives on herpes simplex virus replication.

  Antiviral chemistry & chemotherapy 19980501

• Discovery of podophyllotoxins.

  Biochimie 19980301

• Navoban (tropisetron, ICS 205-930) and dexamethasone combination in the prevention of vomiting for patients receiving preconditioning high-dose chemotherapy before marrow transplantation.

  Japanese journal of clinical oncology 19980201

• Safety and efficacy of 0.5% podofilox gel in the treatment of anogenital warts.

  Archives of dermatology 19980101

• Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent.

  Cancer research 19970815

• Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids.

  Carcinogenesis 19960301

• Differential in vitro anti-HIV activity of natural lignans.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 19900101

• Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.

  Molecular pharmacology 19880801

• Etoposide-induced hypersensitivity reactions. Report of two cases.

  Chemioterapia : international journal of the Mediterranean Society of Chemotherapy 19851201

• Transient heart block. An unreported toxicity of high dose chemotherapy with cyclophosphamide and etoposide.

  Acta clinica Belgica 19850101

• High-dose etoposide for refractory malignancies: a phase I study.

  Cancer treatment reports 19841201

• Tumor lysis syndrome following VP-16-213 in chronic myeloid leukemia in blast crisis.

  American journal of hematology 19840201

• Lack of potentiation of vincristine-induced neurotoxicity by VP-16-213.

  American journal of clinical oncology 19830601

• Possible enhancement of vincristine neuropathy by VP-16.

  Cancer 19820301

• A phase I trial of continuous infusion VP16-213 (etoposide).

  Cancer chemotherapy and pharmacology 19820101

• Combined VM-26 and cytosine arabinoside in treatment of refractory childhood lymphocytic leukemia.

  Cancer 19800315

• Prophylaxis of bladder tumor implantation. Intravesical and systemic chemotherapy.

  Urology 19760101

• 4'-demethyl-epipodophyllotoxin-beta-D-thenylidene glucoside (VM-26)--a brief review.

  European journal of cancer 19730701