51803-78-2 | N-(4-nitro-2-phenoxyphenyl)methanesulfonamide

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$11.00	$8.00
25mg	98%	in stock	$13.00	$9.00
100mg	98%	in stock	$16.00	$11.00
1g	98%	in stock	$19.00	$13.00
5g	98%	in stock	$23.00	$16.00
10g	98%	in stock	$42.00	$30.00
25g	98%	in stock	$97.00	$68.00
100g	98%	in stock	$297.00	$208.00

Description

• Catalog Number: AI51610
• Chemical Name: N-(4-nitro-2-phenoxyphenyl)methanesulfonamide
• CAS Number: 51803-78-2
• Molecular Formula: C13H12N2O5S
• Molecular Weight: 308.3098
• MDL Number: MFCD00079470
• SMILES: [O-][N+](=O)c1ccc(c(c1)Oc1ccccc1)NS(=O)(=O)C
• NSC Number: 758412

Computed Properties

• Complexity: 450
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 2.6

Literature

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  Comparative hepatology 20110101

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  Journal of toxicology 20110101

• Celecoxib: considerations regarding its potential disease-modifying properties in osteoarthritis.

  Arthritis research & therapy 20110101

• Targeting KSHV/HHV-8 latency with COX-2 selective inhibitor nimesulide: a potential chemotherapeutic modality for primary effusion lymphoma.

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  Chemistry Central journal 20110101

• Efficacy and Safety of COX-2 Inhibitors in the Clinical Management of Arthritis: Mini Review.

  ISRN pharmacology 20110101

• Randomized split-mouth study on postoperative effects of palmitoylethanolamide for impacted lower third molar surgery.

  ISRN surgery 20110101

• Paraneoplastic syndrome mimicking adult-onset Still's disease caused by advanced lung cancer: a case report.

  BMC cancer 20110101

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  Ayu 20110101

• Treatment of early arthritis using arthrofoon (ultra-low doses of antibodies to tumor necrosis factor-α).

  Indian journal of pharmacology 20110101

• Bilateral spontaneous retroperitoneal bleeding in a patient on nimesulide: a case report.

  Journal of medical case reports 20110101

• Investigation of microemulsion system for transdermal delivery of itraconazole.

  Journal of advanced pharmaceutical technology & research 20110101

• TTF-1 action on the transcriptional regulation of cyclooxygenase-2 gene in the rat brain.

  PloS one 20110101

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• Removal of oral lichen planus by CO2 laser.

  Brazilian dental journal 20110101

• Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.

  PloS one 20110101

• Cyclooxygenase-2-expressing macrophages in human pterygium co-express vascular endothelial growth factor.

  Molecular vision 20110101

• Formulation and optimization of mucoadhesive nanodrug delivery system of acyclovir.

  Journal of young pharmacists : JYP 20110101

• Fast disintegrating tablets: Opportunity in drug delivery system.

  Journal of advanced pharmaceutical technology & research 20110101

• Formulation and evaluation of fast dissolving tablets of cinnarizine using superdisintegrant blends and subliming material.

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  Pharmacognosy reviews 20110101

• Development and validation of simultaneous spectrophotometric methods for drotaverine hydrochloride and aceclofenac from tablet dosage form.

  Indian journal of pharmaceutical sciences 20110101

• Lallemantia reylenne seeds as superdisintegrant: Formulation and evaluation of nimesulide orodispersible tablets.

  International journal of pharmaceutical investigation 20110101

• Prostaglandins mediate depressive-like behaviour induced by endotoxin in mice.

  Behavioural brain research 20101220

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• Non-steroidal anti-inflammatory drugs: What is the actual risk of liver damage?

  World journal of gastroenterology 20101207

• Non-steroidal anti-inflammatory drugs may modulate the protease activity of Candida albicans.

  Microbial pathogenesis 20101201

• Effects of aspirin and nimesulide on tissue damage in diabetic rats.

  Cytokine 20101201

• A predictive ligand-based Bayesian model for human drug-induced liver injury.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Chemoprevention of chemically induced skin tumorigenesis by ligand activation of peroxisome proliferator-activated receptor-beta/delta and inhibition of cyclooxygenase 2.

  Molecular cancer therapeutics 20101201

• Comparison of analgesic effects of nimesulide, paracetamol, and their combination in animal models.

  Indian journal of pharmacology 20101201

• Olanzapine-induced hepatopathy in albino rats: A newer model for screening putative hepatoprotective agents, namely silymarin.

  Indian journal of pharmacology 20101201

• Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

  Healthcare informatics research 20101201

• Neutrophil- and myeloperoxidase-mediated metabolism of reduced nimesulide: evidence for bioactivation.

  Chemical research in toxicology 20101115

• Augmented cyclooxygenase-2 effects on renal function during varying states of angiotensin II.

  American journal of physiology. Renal physiology 20101101

• Cyclooxygenase-2 mediates anandamide metabolism in the mouse brain.

  The Journal of pharmacology and experimental therapeutics 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Radiation recall with anticancer agents.

  The oncologist 20101101

• [Effect of Bizhongxiao decoction on proteomics of peripheral blood mononuclear cells in patients with rheumatoid arthritis].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20101101

• ['Doing something good' for the body? Definitely not! Liver damage caused by food supplements].

  MMW Fortschritte der Medizin 20101028

• Nimesulide improves the disease modifying anti-rheumatic profile of methotrexate in mice with collagen-induced arthritis.

  European journal of pharmacology 20101010

• COX-2 inhibitor nimesulide analogs are aromatase suppressors in breast cancer cells.

  The Journal of steroid biochemistry and molecular biology 20101001

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  Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20101001

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  European annals of allergy and clinical immunology 20101001

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  Toxicology 20100910

• Endothelium-dependent contraction induced by acetylcholine in the chicken ductus arteriosus involves cyclooxygenase-1 activation and TP receptor stimulation.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20100901

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  Critical care medicine 20100901

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• Comparison of cyclooxygenase-1 crystal structures: cross-talk between monomers comprising cyclooxygenase-1 homodimers.

  Biochemistry 20100824

• Structural and binding studies of C-terminal half (C-lobe) of lactoferrin protein with COX-2-specific non-steroidal anti-inflammatory drugs (NSAIDs).

  Archives of biochemistry and biophysics 20100815

• Acute low back pain with radiculopathy: a double-blind, randomized, placebo-controlled study.

  Photomedicine and laser surgery 20100801

• Similar antineoplastic effects of nimesulide, a selective COX-2 inhibitor, and prostaglandin E1 on B16-F10 murine melanoma cells.

  Melanoma research 20100801

• [Nimesulide: 25 years later].

  Minerva medica 20100801

• Interaction of PGHS-2 and glutamatergic mechanisms controlling the ovine fetal hypothalamus-pituitary-adrenal axis.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100701

• Increased risk of hospitalization for acute hepatitis in patients with previous exposure to NSAIDs.

  Pharmacoepidemiology and drug safety 20100701

• In vitro and ex vivo inhibition of canine cyclooxygenase isoforms by robenacoxib: a comparative study.

  Research in veterinary science 20100601

• Synthesis and biological evaluation of some pyrazolylpyrazolines as anti-inflammatory-antimicrobial agents.

  European journal of medicinal chemistry 20100601

• Efficacy of nimesulide versus meloxicam in the control of pain, swelling and trismus following extraction of impacted lower third molar.

  International journal of oral and maxillofacial surgery 20100601

• Anaphylactoid reaction after injection of ketorolac in a loading dose for patient-controlled analgesia -A case report-.

  Korean journal of anesthesiology 20100601

• Effects of COX-2 inhibition on spinal nociception: the role of endocannabinoids.

  British journal of pharmacology 20100601

• Effect of preferential cyclooxygenase-2 (COX-2) inhibitor against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced striatal lesions in rats: behavioral, biochemical and histological evidences.

  Indian journal of experimental biology 20100601

• In vitro-in vivo correlation study on nimesulide loaded hydroxypropylmethylcellulose microparticles.

  Yao xue xue bao = Acta pharmaceutica Sinica 20100601

• 4-Nitro-2-phenoxy-aniline.

  Acta crystallographica. Section E, Structure reports online 20100601

• Nimesulide-induced electrophile stress activates Nrf2 in human hepatocytes and mice but is not sufficient to induce hepatotoxicity in Nrf2-deficient mice.

  Chemical research in toxicology 20100517

• Novel milk-based oral formulations: proof of concept.

  International journal of pharmaceutics 20100510

• In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives.

  European journal of medicinal chemistry 20100501

• A clinical picture of chronic polyarticular tophaceous gout.

  Rheumatology international 20100401

• Addition of nimesulide to small intestinal submucosa biomaterial inhibits postsurgical adhesiogenesis in rats.

  Journal of biomedical materials research. Part B, Applied biomaterials 20100401

• Assessment of cytotoxic and clastogenic effects of nimesulide: an NSAID drug in somatic cells of BALB/c mice in vivo.

  Drug and chemical toxicology 20100401

• Involvement of mitochondria mediated pathways in hepatoprotection conferred by Fumaria parviflora Lam. extract against nimesulide induced apoptosis in vitro.

  Toxicology in vitro : an international journal published in association with BIBRA 20100301

• The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1.

  Brain, behavior, and immunity 20100301

• Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats.

  Neurotoxicology 20100301

• The COX-2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain.

  British journal of pharmacology 20100301

• Bioavailability of two oral suspension and two oral tablet formulations of nimesulide 100 mg in healthy Brazilian adult subjects.

  International journal of clinical pharmacology and therapeutics 20100301

• [Mechanistic study of nimesulide on enhancing gammadeltaT cell-mediated killing of gastric cancer cells].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20100301

• Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6).

  Journal of ethnopharmacology 20100217

• Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor.

  British journal of cancer 20100216

• Analysis of activity and inhibition of oxygen-dependent enzymes by optical respirometry on the LightCycler system.

  Analytical biochemistry 20100215

• Clinical course and outcomes of drug-induced liver injury: nimesulide as the first implicated medication.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20100201

• Hyperoxia and prevention of adhesion formation: a laparoscopic mouse model for open surgery.

  BJOG : an international journal of obstetrics and gynaecology 20100201

• Trends in the non-steroidal anti-inflammatory drug market in six Central-Eastern European countries based on retail information.

  Pharmacoepidemiology and drug safety 20100201

• Suppressive effect of COX2 inhibitor on the progression of adipose inflammation in high-fat-induced obese rats.

  European journal of clinical investigation 20100201

• Enhancement of tongue carcinogenesis in Hras128 transgenic rats treated with 4-nitroquinoline 1-oxide.

  Oncology reports 20100201

• Absorption and distribution of etoricoxib in plasma, CSF, and wound tissue in patients following hip surgery--a pilot study.

  Naunyn-Schmiedeberg's archives of pharmacology 20100201

• Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress.

  Neuroscience bulletin 20100201

• Kaposi's sarcoma associated herpes virus (KSHV) induced COX-2: a key factor in latency, inflammation, angiogenesis, cell survival and invasion.

  PLoS pathogens 20100201

• Transglutaminase-dependent antiproliferative and differentiative properties of nimesulide on B16-F10 mouse melanoma cells.

  Amino acids 20100101

• Ligand activation of peroxisome proliferator-activated receptor-beta/delta and inhibition of cyclooxygenase-2 enhances inhibition of skin tumorigenesis.

  Toxicological sciences : an official journal of the Society of Toxicology 20100101

• Interaction of nimesulide, a cyclooxygenase-2 inhibitor, with cisplatin in normotensive and spontaneously hypertensive rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101

• Degeneration of dopaminergic neurons induced by thrombin injection in the substantia nigra of the rat is enhanced by dexamethasone: role of monoamine oxidase enzyme.

  Neurotoxicology 20100101

• A computer simulation of progesterone and Cox2 inhibitor treatment for preterm labor.

  PloS one 20100101

• Prescriptions for selective cyclooxygenase-2 inhibitors, non-selective non-steroidal anti-inflammatory drugs, and risk of breast cancer in a population-based case-control study.

  Breast cancer research : BCR 20100101

• Gene expression profiles identify inflammatory signatures in dendritic cells.

  PloS one 20100101

• [Drug-induced liver injury from the dietary supplement Fortodol. A manipulated preparation delayed the diagnosis].

  Lakartidningen 20100101

• Disruption of actin filaments induces mitochondrial Ca2+ release to the cytoplasm and [Ca2+]c changes in Arabidopsis root hairs.

  BMC plant biology 20100101

• The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies.

  International journal of cell biology 20100101

• Rare bilateral nasopalatine duct cysts: a case report.

  The open dentistry journal 20100101

• Effects of selective and non-selective cyclooxygenase (COX) inhibitors on postoperative adhesion formation in a rat uterine horn model.

  Clinical and experimental obstetrics & gynecology 20100101

• [Efficacy and tolerability of short courses of nonsteroid anti-inflammatory drugs in the treatment of dorsalgia: results of the comparative study].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• Formulation of two-drug controlled release non-biodegradable microparticles for potential treatment of muscles pain and spasm and their simultaneous spectrophotometeric estimation.

  Acta poloniae pharmaceutica 20100101

• Presenilin/gamma-Secretase and Inflammation.

  Frontiers in aging neuroscience 20100101

• Effects of the European restrictive actions concerning nimesulide prescription: a simulation study on hepatopathies and gastrointestinal bleedings in Italy.

  Annali dell'Istituto superiore di sanita 20100101

• In vitro antibacterial activity of Ibuprofen and acetaminophen.

  Journal of global infectious diseases 20100101

• Hydrogen peroxide regulates glucose-regulated protein 78 expression via a cyclooxygenase-2 dependent mechanism.

  Journal of biochemical and molecular toxicology 20100101

• Cytosolic phospholipase A2 alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice.

  Journal of neuroinflammation 20100101

• Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment?

  Frontiers in aging neuroscience 20100101

• Recent advancement in nonsteroidal aromatase inhibitors for treatment of estrogen-dependent breast cancer.

  Current medicinal chemistry 20100101

• Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway.

  PloS one 20100101

• Adverse effects of extra-articular corticosteroid injections: a systematic review.

  BMC musculoskeletal disorders 20100101

• Study of nephrotoxic potential of acetaminophen in birds.

  Toxicology international 20100101

• Microencapsulation: an acclaimed novel drug-delivery system for NSAIDs in arthritis.

  Critical reviews in therapeutic drug carrier systems 20100101

• Preparation and in vitro/in vivo characterization of porous sublingual tablets containing ternary kneaded solid system of vinpocetine with î-cyclodextrin and hydroxy Acid.

  Scientia pharmaceutica 20100101

• Preparation and in vivo evaluation of indomethacin loaded true nanoemulsions.

  Scientia pharmaceutica 20100101

• Prevalence of pharmacotherapy in the department of paediatric dentistry.

  Kathmandu University medical journal (KUMJ) 20100101

• Formulation design and optimization of fast disintegrating Lorazepam tablets by effervescent method.

  Indian journal of pharmaceutical sciences 20100101

• Formulation and evaluation of mouth dissolving tablets of cinnarizine.

  Indian journal of pharmaceutical sciences 20100101

• Formulation and evaluation of extended-release solid dispersion of metformin hydrochloride.

  Journal of young pharmacists : JYP 20100101

• A pharmacovigilance study in medicine department of tertiary care hospital in chhattisgarh (jagdalpur), India.

  Journal of young pharmacists : JYP 20100101

• Phase IV of Drug Development.

  Perspectives in clinical research 20100101

• Bioenhancers: Revolutionary concept to market.

  Journal of Ayurveda and integrative medicine 20100101

• In vitro evaluation of domperidone mouth dissolving tablets.

  Indian journal of pharmaceutical sciences 20100101

• Orodispersible tablets: A new trend in drug delivery.

  Journal of natural science, biology, and medicine 20100101

• Practice of rational drug uses in a rural area of 24 pgs(s) in West Bengal.

  Journal of advanced pharmaceutical technology & research 20100101

• Cyclooxygenase competitive inhibitors alter tyrosyl radical dynamics in prostaglandin H synthase-2.

  Biochemistry 20091222

• Protective effect of cyclooxygenase (COX)-inhibitors against drug-induced catatonia and MPTP-induced striatal lesions in rats.

  Pharmacology, biochemistry, and behavior 20091201

• Development and validation of a discriminative dissolution test for nimesulide suspensions.

  AAPS PharmSciTech 20091201

• Lead optimization of COX-2 inhibitor nimesulide analogs to overcome aromatase inhibitor resistance in breast cancer cells.

  Bioorganic & medicinal chemistry letters 20091201

• The antinociceptive and anti-inflammatory activities of caulerpin, a bisindole alkaloid isolated from seaweeds of the genus Caulerpa.

  Marine drugs 20091201

• Gastrointestinal and cardiovascular risk of non-selective NSAIDs and COX-2 inhibitors in elderly patients with knee osteoarthritis.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20091201

• Mmp-9, a potential target for cerebral ischemic treatment.

  Current neuropharmacology 20091201

• Cyclooxygenase 2 and Prostaglandin E2 are not Involved in N-Nitrosodiethylamine-Initiated Early Rat Hepatocarcinogenesis.

  Journal of toxicologic pathology 20091201

• Eicosanoids influence insect susceptibility to nucleopolyhedroviruses.

  Journal of invertebrate pathology 20091101

• Metabolomics in drug intolerance.

  Current drug metabolism 20091101

• Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors.

  Journal of medicinal chemistry 20091008

• Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs.

  Molecular carcinogenesis 20091001

• Psoriasiform fixed drug eruption caused by nimesulide.

  Clinical and experimental dermatology 20091001

• Nitric oxide dilates rat retinal blood vessels by cyclooxygenase-dependent mechanisms.

  American journal of physiology. Regulatory, integrative and comparative physiology 20091001

• Diclofenac-induced biochemical and histopathological changes in white leghorn birds (Gallus domesticus).

  Indian journal of pharmacology 20091001

• Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.

  European journal of medicinal chemistry 20090901

• In vitro and in vivo evaluation of nimesulide lyophilized orally disintegrating tablets.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20090901

• Effects of a cyclooxygenase-2 preferential inhibitor in young healthy dogs exposed to air pollution: a pilot study.

  Toxicologic pathology 20090801

• Drug-induced liver disease: an 8-year study of patients from one gastroenterological department.

  Journal of digestive diseases 20090801

• Therapeutic class-specific signal detection of bradycardia associated with propranolol hydrochloride.

  Indian journal of pharmacology 20090801

• Determination of drug-like properties of a novel antileishmanial compound: In vitro absorption, distribution, metabolism, and excretion studies.

  Indian journal of pharmacology 20090801

• Anti-inflammatory effects of ethanolic extract and alkamides-derived from Heliopsis longipes roots.

  Journal of ethnopharmacology 20090730

• Mathematical modeling of pH-surfactant-mediated solubilization of nimesulide.

  Drug development and industrial pharmacy 20090701

• Preparation and evaluation of nimesulide-loaded ethylcellulose and methylcellulose nanoparticles and microparticles for oral delivery.

  Journal of biomaterials applications 20090701

• Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.

  Toxicology and applied pharmacology 20090615

• A COX-2 inhibitor nimesulide analog selectively induces apoptosis in Her2 overexpressing breast cancer cells via cytochrome c dependent mechanisms.

  Biochemical pharmacology 20090615

• Comment on: severe hemolytic anemia and fatal hepatic failure associated with nimesulide.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20090601

• COX-2-mediated inflammation in fat is crucial for obesity-linked insulin resistance and fatty liver.

  Obesity (Silver Spring, Md.) 20090601

• Prevention of adhesion formation in a laparoscopic mouse model should combine local treatment with peritoneal cavity conditioning.

  Human reproduction (Oxford, England) 20090601

• Enhancement of doxorubicin cytotoxicity on human esophageal squamous cell carcinoma cells by indomethacin and 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC236) via inhibiting P-glycoprotein activity.

  Molecular pharmacology 20090601

• Blockade of PGHS-2 inhibits the hypothalamus-pituitary-adrenal axis response to cerebral hypoperfusion in the sheep fetus.

  American journal of physiology. Regulatory, integrative and comparative physiology 20090601

• Murine typhus in child, Yucatan, Mexico.

  Emerging infectious diseases 20090601

• The effects of cardiovascular risk factors on cognitive compromise.

  Dialogues in clinical neuroscience 20090601

• Lack of effect of naltrindole on the spinal synergism of morphine and non-steroidal anti-inflammatory drugs (NSAIDS).

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090601

• Nicotine enhances migration and invasion of human esophageal squamous carcinoma cells which is inhibited by nimesulide.

  World journal of gastroenterology 20090528

• Unique endoscopy findings in collagenous colitis.

  Gastrointestinal endoscopy 20090501

• Nimesulide, a selective COX-2 inhibitor, acts synergistically with ionizing radiation against A549 human lung cancer cells through the activation of caspase-8 and caspase-3.

  International journal of oncology 20090501

• The cyclooxygenase-2 inhibitor nimesulide, a nonsteroidal analgesic, decreases the effect of radiation therapy in head-and-neck cancer cells.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20090501

• Importance of cyclooxygenase 2-mediated low-grade inflammation in the development of fructose-induced insulin resistance in rats.

  The Chinese journal of physiology 20090430

• Nimesulide inhibits IFN-gamma-induced programmed death-1-ligand 1 surface expression in breast cancer cells by COX-2 and PGE2 independent mechanisms.

  Cancer letters 20090408

• Inhibition of cyclooxygenase-2 and EP1 receptor antagonism reduces human colonic longitudinal muscle contractility in vitro.

  Prostaglandins & other lipid mediators 20090401

• Synergism between NSAIDs in the orofacial formalin test in mice.

  Pharmacology, biochemistry, and behavior 20090401

• Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation.

  Nature chemical biology 20090401

• Too much effectiveness from a herbal drug.

  British journal of clinical pharmacology 20090401

• [Hematuria caused by oral nimesulide in 2 infants].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20090401

• [Acute liver failure due to a treatment by nimesulide].

  Annales francaises d'anesthesie et de reanimation 20090301

• Selective cyclooxygenase-2 inhibition protects against myocardial damage in experimental acute ischemia.

  Clinics (Sao Paulo, Brazil) 20090301

• The warming acupuncture for treatment of sciatica in 30 cases.

  Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20090301

• A comparative study on oxidative stress induced by LPS and rotenone in homogenates of rat brain regions.

  Environmental toxicology and pharmacology 20090301

• Separation and determination of nimesulide related substances for quality control purposes by micellar electrokinetic chromatography.

  Journal of pharmaceutical and biomedical analysis 20090220

• Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: orally effective anti-inflammatory drug candidates.

  Bioorganic & medicinal chemistry 20090201

• Diagnostic delay and suboptimal management in a referral population with hemicrania continua.

  Headache 20090201

• Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid.

  Aging 20090201

• A review of analytical techniques for determination of oxicams, nimesulide and nabumetone.

  Talanta 20090115

• Effects of cyclooxygenase-2 non-selective and selective inhibitors on proliferation inhibition and apoptosis induction of esophageal squamous carcinoma cells.

  Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20090101

• Severe hemolytic anemia and fatal hepatic failure associated with nimesulide.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20090101

• In vitro nimesulide studies toward understanding idiosyncratic hepatotoxicity: diiminoquinone formation and conjugation.

  Chemical research in toxicology 20090101

• Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin.

  Reproductive biology and endocrinology : RB&E 20090101

• Effects of nimesulide, acetylsalicylic acid, ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo.

  Basic & clinical pharmacology & toxicology 20090101

• Characterization of SV-40 Tag rats as a model to study prostate cancer.

  BMC cancer 20090101

• Complexation of cox-2 inhibitors with bovine serum albumin: interaction mechanism.

  Pharmaceutical development and technology 20090101

• Comment on: nimesulide and adverse drug reactions: time for a database.

  Journal of postgraduate medicine 20090101

• Information about ADRs explored by pharmacovigilance approaches: a qualitative review of studies on antibiotics, SSRIs and NSAIDs.

  BMC clinical pharmacology 20090101

• In vitro ultramorphological assessment of apoptosis induced by zerumbone on (HeLa).

  Journal of biomedicine & biotechnology 20090101

• Competition between COX-2 inhibitors and some other drugs for binding sites on human serum albumin.

  Drug metabolism and drug interactions 20090101

• Efficacy and safety of two generic copies of nimesulide in patients with low back pain or knee osteoarthritis.

  Reumatismo 20090101

• Lack of effect of naltrexone on the spinal synergism between morphine and non steroidal anti-inflammatory drugs.

  Pharmacological reports : PR 20090101

• Role of cyclooxygenase in vasodilation of retinal blood vessels induced by bradykinin in Brown Norway rats.

  Vascular pharmacology 20090101

• Chloroform extract of cigarette smoke induces proliferation of human esophageal squamous-cell carcinoma cells: modulation by beta-adrenoceptors.

  Drug and chemical toxicology 20090101

• Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer.

  BMC cancer 20090101

• Reason for the aggravation of diseases caused by inflammation and the ineffectiveness of NSAIDs on these diseases in rainy weather.

  Pharmacological reports : PR 20090101

• Spatiotemporal correlations between blood-brain barrier permeability and apparent diffusion coefficient in a rat model of ischemic stroke.

  PloS one 20090101

• Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy.

  Molecular cancer 20090101

• Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice.

  BMC neuroscience 20090101

• [Detection of nimesulide in biological materials].

  Sudebno-meditsinskaia ekspertiza 20090101

• Effects of nonsteroidal anti-inflammatory drugs on the expression and function of P-glycoprotein/MDR1 in Caco-2 cells.

  Drug and chemical toxicology 20090101

• Drugs associated with more suicidal ideations are also associated with more suicide attempts.

  PloS one 20090101

• [New potentialities in symptom-modifying therapy of osteoarthrosis].

  Terapevticheskii arkhiv 20090101

• Possible link between history of hypersensitivity to a specific non-steroidal anti-inflammatory drug (NSAID) and positive results following challenge test to alternative NSAIDS.

  Arzneimittel-Forschung 20090101

• Guaifenesin enhances the analgesic potency of ibuprofen, nimesulide and celecoxib in mice.

  Neuro endocrinology letters 20090101

• Randomised controlled trial of local corticosteroid injections for de Quervain's tenosynovitis in general practice.

  BMC musculoskeletal disorders 20090101

• Influence of nonsteroidal anti-inflammatory drugs on progesterone production by cultured bovine luteal cells.

  Polish journal of veterinary sciences 20090101

• [Low back pain in young subjects: a new approach to therapy].

  Terapevticheskii arkhiv 20090101

• [Cholestatic hepatitis associated with nimesulide--a case report].

  Srpski arhiv za celokupno lekarstvo 20090101

• Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles.

  PloS one 20090101

• Current and emerging treatments for amyotrophic lateral sclerosis.

  Neuropsychiatric disease and treatment 20090101

• [Comparative analysis of effectiveness and safety of diclofenac and nimesulide in patients with early rheumatoid arthritis].

  Klinicheskaia meditsina 20090101

• Role of prostaglandins and specific place in therapy of bimatoprost in the treatment of elevated intraocular pressure and ocular hypertension: A closer look at the agonist properties of bimatoprost and the prostamides.

  Clinical ophthalmology (Auckland, N.Z.) 20090101

• Evaluation of gastric tolerability, antinociceptive and antiinflammatory activity of combination NSAIDs in rats.

  Indian journal of dental research : official publication of Indian Society for Dental Research 20090101

• Various solvent systems for solubility enhancement of enrofloxacin.

  Indian journal of pharmaceutical sciences 20090101

• Suppression of constitutively expressed cyclooxygenase-2 in the epididymis of mice by nimesulide decreases sperm motility.

  Journal of basic and clinical physiology and pharmacology 20090101

• Formulation design and optimization of fast dissolving clonazepam tablets.

  Indian journal of pharmaceutical sciences 20090101

• Pain management in pediatric age group.

  Indian journal of palliative care 20090101

• Selective COX-2 inhibitors modulate cellular senescence in human dermal fibroblasts in a catalytic activity-independent manner.

  Mechanisms of ageing and development 20081201

• Comments on assessment of drug-induced liver injury in clinical practice by Lucena MI et al., Fundamental & Clinical Pharmacology 2008; 22: 141-158.

  Fundamental & clinical pharmacology 20081201

• Four-week administration of nimesulide, a cyclooxygenase-2 inhibitor, improves endothelial dysfunction in the hindlimb vasculature of streptozotocin-induced diabetic rats.

  Archives of pharmacal research 20081201

• [Research advance on pediatric antipyretic].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20081201

• Indirect role of beta2-adrenergic receptors in the mechanism of anti-inflammatory action of NSAIDS.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20081201

• Nimesulide associated fulminant hepatic failure.

  Pharmacoepidemiology and drug safety 20081101

• Effect of pH and water-soluble polymers on the aqueous solubility of nimesulide in the absence and presence of beta-cyclodextrin derivatives.

  The Journal of pharmacy and pharmacology 20081101

• Negrin Dastis S. et al.: Liver transplantation for nonsteroidal anti-inflammatory drug-induced liver failure: nimesulide as the first implicated compound. Eur J Gastroenterol Hepatol 2007; 19:919-922.

  European journal of gastroenterology & hepatology 20081101

• The effects of etodolac, nimesulid and naproxen sodium on the frequency of sister chromatid exchange after enclused third molars surgery.

  Yonsei medical journal 20081031

• Effect of thermodynamic activities of the unionized and ionized species on drug flux across buccal mucosa.

  Journal of pharmaceutical sciences 20081001

• Drug policy research & pharmacoeconomics.

  Indian journal of pharmacology 20081001

• Clinical pharmacology.

  Indian journal of pharmacology 20081001

• Pharmacovigilance and pharmacoepidemiology.

  Indian journal of pharmacology 20081001

• Strategies to minimize discomfort during diagnostic hysterosalpingography with disposable balloon catheters: a randomized placebo-controlled study with oral nonsteroidal premedication.

  Fertility and sterility 20080901

• Cellular imaging predictions of clinical drug-induced liver injury.

  Toxicological sciences : an official journal of the Society of Toxicology 20080901

• Cyclooxygenase inhibitors down regulate P-glycoprotein in human colorectal Caco-2 cell line.

  Pharmaceutical research 20080901

• Determination of rupatadine in pharmaceutical formulations by a validated stability-indicating MEKC method.

  Journal of separation science 20080901

• [Acute liver failure due to a treatment by nimesulide: another case and review].

  Annales francaises d'anesthesie et de reanimation 20080901

• Estrogen protects the heart from ischemia-reperfusion injury via COX-2-derived PGI2.

  Journal of cardiovascular pharmacology 20080901

• Chondroprotective Potential of Fruit Extracts of Phyllanthus emblica in Osteoarthritis.

  Evidence-based complementary and alternative medicine : eCAM 20080901

• Synthesis and anti-inflammatory evaluation of methylene bridged benzofuranyl imidazo[2,1-b][1,3,4]thiadiazoles.

  European journal of medicinal chemistry 20080801

• Effect of nonsteroidal anti-inflammatory drugs on the cellular membrane fluidity.

  Journal of pharmaceutical sciences 20080801

• Inhibition of brain prostaglandin endoperoxide synthase-2 prevents the preparturient increase in fetal adrenocorticotropin secretion in the sheep fetus.

  Endocrinology 20080801

• Morphine, opioids, and the feline pulmonary vascular bed.

  Acta anaesthesiologica Scandinavica 20080801

• Apparently unexplainable hypoglycemia in a diabetic patient--clue for renal failure?

  The Journal of the Association of Physicians of India 20080801

• Allosteric modulation of SULT2A1 by celecoxib and nimesulide: computational analyses.

  Drug metabolism letters 20080801

• Spectrophotometric monitoring of nimesulide photodegradation by a combined hard-soft multivariate curve resolution-alternative least square method.

  Journal of pharmaceutical and biomedical analysis 20080715

• Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain.

  Neuropharmacology 20080701

• Cyclooxygenase-2 derived PGE2 and PGI2 play an important role via EP2 and PPARdelta receptors in early steps of oil induced decidualization in mice.

  Placenta 20080601

• ATP induces guinea pig gallbladder smooth muscle excitability via the P2Y4 receptor and COX-1 activity.

  American journal of physiology. Gastrointestinal and liver physiology 20080601

• Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy: effect of nimesulide.

  Metabolic brain disease 20080601

• Comparison between two cyclooxygenase inhibitors in an experimental dry eye model in albino rabbits.

  Acta pharmaceutica (Zagreb, Croatia) 20080601

• [Acute cholestasis following treatment with nimesulide and oral contraception: case report and review].

  Vnitrni lekarstvi 20080601

• A comparative clinical trial evaluating efficacy and safety of fixed dose combination of nimesulide (100 mg) and racemethionine (50 mg) (namsafe) versus reference drug (nimesulide) and other NSAIDs in the treatment of osteoarthritis.

  Journal of the Indian Medical Association 20080601

• In vivo inhibition of prostaglandin e(2) production by crude aqueous extract of the root bark of zanthoxylum xanthoxyloides.

  Ghana medical journal 20080601

• Selective hypersensitivity to nimesulide.

  Allergy 20080501

• Nimesulide-induced hepatotoxicity and fatal hepatic failure.

  Singapore medical journal 20080501

• Re-expansion pulmonary oedema: is its prevention possible?

  Interactive cardiovascular and thoracic surgery 20080501

• Prescribing pattern of drugs in the treatment of osteoarthritis in Italian general practice: the effect of rofecoxib withdrawal.

  Arthritis and rheumatism 20080415

• Characterization of changes in the viscosity of lipid membranes with the molecular rotor FCVJ.

  Biochimica et biophysica acta 20080401

• Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity.

  British journal of pharmacology 20080401

• Toxoplasma gondii induces prostaglandin E2 synthesis in macrophages via signal pathways for calcium-dependent arachidonic acid production and PKC-dependent induction of cyclooxygenase-2.

  Parasitology research 20080401

• [Synergistic lethal effect of mDRA-6 and nimesulide on human hepatocellular cancer cell line SMMC-7721].

  Ai zheng = Aizheng = Chinese journal of cancer 20080401

• Nimesulide as a promising neuroprotectant in brain ischemia: new experimental evidences.

  Pharmacological research 20080401

• Using factorial design to improve the solubility and in-vitro dissolution of nimesulide hydrophilic polymer binary systems.

  Drug discoveries & therapeutics 20080401

• Novel sulfonanilide analogs decrease aromatase activity in breast cancer cells: synthesis, biological evaluation, and ligand-based pharmacophore identification.

  Journal of medicinal chemistry 20080313

• Analgesic, anti-inflammatory and antioxidant properties of Buddleja globosa, Buddlejaceae.

  Journal of ethnopharmacology 20080305

• Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitis.

  Drug metabolism and disposition: the biological fate of chemicals 20080301

• Effect of trikatu pretreatment on the pharmacokinetics of pefloxacin administered orally in mountain Gaddi goats.

  Journal of veterinary science 20080301

• Lymphangitis in a Portuguese patient infected with Rickettsia sibirica.

  Emerging infectious diseases 20080301

• Involvement of endogenous prostaglandin F2alpha on kainic acid-induced seizure activity through FP receptor: the mechanism of proconvulsant effects of COX-2 inhibitors.

  Brain research 20080208

• Differential effects of selective cyclooxygenase-2 inhibitors in inhibiting proliferation and induction of apoptosis in oral squamous cell carcinoma.

  Oncology reports 20080201

• Effects of nimesulide, a cyclooxygenase-2 selective inhibitor, on colitis induced tumors.

  Inflammopharmacology 20080201

• Nimesulide and hepatitis: death, transplantation; regulatory failures.

  Prescrire international 20080201

• [The effect of cyclooxygenase-2 on lymphangiogenesis in breast cancer].

  Zhonghua wai ke za zhi [Chinese journal of surgery] 20080115

• Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms.

  Carcinogenesis 20080101

• Effects of cyclooxygenase inhibition on canine coronary artery blood flow and thrombosis.

  American journal of physiology. Heart and circulatory physiology 20080101

• Renoprotective effects of neuronal NOS-derived nitric oxide and cyclooxygenase-2 metabolites in transgenic rats with inducible malignant hypertension.

  American journal of physiology. Renal physiology 20080101

• Effects of nonsteroidal anti-inflammatory drugs on the expression of urokinase plasminogen activator and inhibitor and gelatinases in the early osteoarthritic knee of humans.

  Clinical biochemistry 20080101

• Effects of aspirin, nimesulide, and SC-560 on vasopressin-induced contraction of human gastroepiploic artery and saphenous vein.

  Critical care medicine 20080101

• Nimesulide 90 mg orally twice daily does not influence postoperative morphine requirements after major chest surgery.

  Anesthesia and analgesia 20080101

• The ACTIVE (Acute Cholecystitis Trial Invasive Versus Endoscopic) study: multicenter randomized, double-blind, controlled trial of laparoscopic (LC) versus open (LTC) surgery for acute cholecystitis (AC) in adults.

  Trials 20080101

• COX-2 mRNA expression in esophageal squamous cell carcinoma (ESCC) and effect by NSAID.

  Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20080101

• No effect of one-year treatment with indomethacin on Alzheimer's disease progression: a randomized controlled trial.

  PloS one 20080101

• Detrimental effects of tropisetron on permanent ischemic stroke in the rat.

  BMC neuroscience 20080101

• Cyclooxygenase-2 inhibitor nimesulide blocks ultraviolet B-induced photocarcinogenesis in SKH-1 hairless mice.

  Photochemistry and photobiology 20080101

• The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective.

  Journal of neuroinflammation 20080101

• Long-term retention on treatment with lumiracoxib 100 mg once or twice daily compared with celecoxib 200 mg once daily: a randomised controlled trial in patients with osteoarthritis.

  BMC musculoskeletal disorders 20080101

• Nimesulide is a selective COX-2 inhibitory, atypical non-steroidal anti-inflammatory drug.

  Current medicinal chemistry 20080101

• Malignant transformation of normal enterocytes following downregulation of Bak expression.

  Digestion 20080101

• Synthesis and biological evaluation of novel sulfonanilide compounds as antiproliferative agents for breast cancer.

  Journal of combinatorial chemistry 20080101

• Peroxisome Proliferator-Activated Receptor-gamma Ligands: Potential Pharmacological Agents for Targeting the Angiogenesis Signaling Cascade in Cancer.

  PPAR research 20080101

• Nimesulide-induced hepatitis and toxic epidermal necrolysis.

  Journal of postgraduate medicine 20080101

• Effects of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of ovarian carcinoma in vivo.

  Medical oncology (Northwood, London, England) 20080101

• Acute premature constriction of the ductus arteriosus after maternal self-medication with nimesulide.

  Fetal diagnosis and therapy 20080101

• NO-Donating NSAIDs, PPARdelta, and Cancer: Does PPARdelta Contribute to Colon Carcinogenesis?

  PPAR research 20080101

• Influence of regulatory measures on the rate of spontaneous adverse drug reaction reporting in Italy.

  Drug safety 20080101

• Interactions between APP secretases and inflammatory mediators.

  Journal of neuroinflammation 20080101

• Effect of different non-steroidal anti-inflammatory drugs, aspirin, nimesulide and celecoxib on the disaccharide hydrolases and histoarchitecture of the rat intestinal brush border membrane.

  Nutricion hospitalaria 20080101

• Nimesulide and adverse drug reactions: time for a database.

  Journal of postgraduate medicine 20080101

• Drug-related deaths: an analysis of the Italian spontaneous reporting database.

  Drug safety 20080101

• [AULIN--treatment in primary dysmenorrhea].

  Akusherstvo i ginekologiia 20080101

• Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial.

  BMJ (Clinical research ed.) 20080101

• A 6-week, multicentre, randomised, double-blind, double-dummy, active-controlled, clinical safety study of lumiracoxib and rofecoxib in osteoarthritis patients.

  BMC musculoskeletal disorders 20080101

• Prescriptions of NSAIDs to patients undergoing third molar surgery : an observational, prospective, multicentre survey.

  Clinical drug investigation 20080101

• Nimesulide-induced, multifocal, urticarial fixed drug eruption confirmed by oral provocation test.

  Indian journal of dermatology, venereology and leprology 20080101

• Effects of celecoxib and nimesulide on the proliferation of ectopic endometrial stromal cells in vitro.

  The Journal of international medical research 20080101

• Comparison of NSAID consumption in Slovakia, Finland and Norway.

  Bratislavske lekarske listy 20080101

• Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway.

  Journal of neuroinflammation 20080101

• Finding multiple target optimal intervention in disease-related molecular network.

  Molecular systems biology 20080101

• T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis.

  Arthritis research & therapy 20080101

• [Experimental NSAID-associated gastric mucosa injuries].

  Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20080101

• The influence of malnutrition on the oral pharmacokinetics of nimesulide in rats.

  Proceedings of the Western Pharmacology Society 20080101

• Comparison of suspension composition on the pharmacokinetics of nimesulide in rats.

  Proceedings of the Western Pharmacology Society 20080101

• Antiinflammatory, analgesic and antipyretic activity of certain thiazolidinones.

  Indian journal of pharmaceutical sciences 20080101

• Optimization of fast dissolving etoricoxib tablets prepared by sublimation technique.

  Indian journal of pharmaceutical sciences 20080101

• Furosemide-loaded Alginate Microspheres Prepared by Ionic Cross-linking Technique: Morphology and Release Characteristics.

  Indian journal of pharmaceutical sciences 20080101

• Relationship between arachidonic acid pathway and human renal cell carcinoma.

  OncoTargets and therapy 20080101

• Preemptive versus postoperative lumiracoxib for analgesia in ambulatory arthroscopic knee surgery.

  Journal of pain research 20080101

• Flow of Formulation Granules through a Conical Hopper.

  Indian journal of pharmaceutical sciences 20080101

• Analysis of bulk sample of salicylic Acid by application of hydrotropic solubilization method.

  Indian journal of pharmaceutical sciences 20080101

• Pharmacological nature of nicotine-induced contraction in the rat basilar artery: involvement of arachidonic acid metabolites.

  European journal of pharmacology 20071222

• Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice.

  Seizure 20071201

• World Institute of Pain (WIP)--Fourth World Congress.

  IDrugs : the investigational drugs journal 20071201

• Anti-inflammatory and immune therapy for Alzheimer's disease: current status and future directions.

  Current neuropharmacology 20071201

• Current therapeutic options for Alzheimer's disease.

  Current genomics 20071201

• The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: signaling pathway.

  American journal of physiology. Heart and circulatory physiology 20071101

• Etoricoxib challenge in patients with chronic urticaria with NSAID intolerance.

  Clinical and experimental dermatology 20071101

• Retrospective analysis of 736 implants inserted without antibiotic therapy.

  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20071101

• Liver transplantation for nonsteroidal anti-inflammatory drug-induced liver failure: nimesulide as the first implicated compound.

  European journal of gastroenterology & hepatology 20071101

• Cyclooxygenase-2 inhibitors demonstrate anti-proliferative effects in oesophageal cancer cells by prostaglandin E(2)-independent mechanisms.

  Cancer letters 20071028

• COX-2 inhibitor nimesulide protects rat heart against oxidative stress by improving endothelial function and enhancing NO production.

  Sheng li xue bao : [Acta physiologica Sinica] 20071025

• Effect of reactive oxygen species scavengers, antiinflammatory drugs, and calcium-channel blockers on carbon dioxide pneumoperitoneum-enhanced adhesions in a laparoscopic mouse model.

  Surgical endoscopy 20071001

• Copper conjugates of nimesulide Schiff bases targeting VEGF, COX and Bcl-2 in pancreatic cancer cells.

  Journal of inorganic biochemistry 20071001

• Efficacy and safety of topical nimesulide in the treatment of knee osteoarthritis.

  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20071001

• [Expression of cyclooxygenase-2 in pterygium and effects of selective cyclooxygenase-2 inhibitor on human pterygium fibroblasts].

  [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20071001

• Inhibition of the myeloperoxidase chlorinating activity by non-steroidal anti-inflammatory drugs: flufenamic acid and its 5-chloro-derivative directly interact with a recombinant human myeloperoxidase to inhibit the synthesis of hypochlorous acid.

  European journal of pharmacology 20070910

• Characterization and compaction behaviour of nimesulide crystal forms.

  International journal of pharmaceutics 20070905

• Rescue therapy by portal infusion of autologous stem cells in a case of drug-induced hepatitis.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20070901

• Nimesulide inhibits crypt epithelial cell proliferation at 6 hours in the small intestine in CD-1 mice.

  Digestive diseases and sciences 20070901

• Efficacy and safety of hydroxychloroquine sulphate in rheumatoid arthritis: a randomized, double-blind, placebo controlled clinical trial--an Indian experience.

  Current medical research and opinion 20070901

• Nimesulide in the treatment of postoperative pain: a double-blind, comparative study in patients undergoing arthroscopic knee surgery.

  The Clinical journal of pain 20070901

• Therapeutic effect of nimesulide on colorectal carcinogenesis in experimental murine ulcerative colitis.

  Journal of gastroenterology and hepatology 20070901

• Comparison of the effect of tromethamine and polyvinylpyrrolidone on dissolution properties and analgesic effect of nimesulide.

  AAPS PharmSciTech 20070901

• [Study on skin toxicology and penetration enhancement of skin absorption of volatile oil extracted from tender branchers of Camellia oleifera].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901

• [The effect of nonsteroidal anti-inflammatory drugs on oxidative/antioxidative balance].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20070901

• Human skin penetration and distribution of nimesulide from hydrophilic gels containing nanocarriers.

  International journal of pharmaceutics 20070816

• Effects of nimesulide on pain and on synovial fluid concentrations of substance P, interleukin-6 and interleukin-8 in patients with knee osteoarthritis: comparison with celecoxib.

  International journal of clinical practice 20070801

• Efficacy of dosing and re-dosing of two oral fixed combinations of indomethacin, prochlorperazine and caffeine compared with oral sumatriptan in the acute treatment of multiple migraine attacks: a double-blind, double-dummy, randomised, parallel group, multicentre study.

  International journal of clinical practice 20070801

• Effect of the NSAID nimesulide on the radical scavenger glutathione S-transferase in patients with osteoarthritis of the knee.

  Current medical research and opinion 20070801

• Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor.

  Cancer research 20070801

• [Cyclooxygenase (COX)-2 expression in a rat duodenoesophageal reflux model and chemoprevention of adenocarcinoma by the selective COX-2 inhibitor nimesulide].

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20070801

• A non-steroidal anti-inflammatory agent provides significant protection during focal ischemic stroke with decreased expression of matrix metalloproteinases.

  Current neurovascular research 20070801

• Nonsteroidal anti-inflammatory drug-induced hepatotoxicity.

  Clinics in liver disease 20070801

• Current treatment options in the management of chronic prostatitis.

  Therapeutics and clinical risk management 20070801

• 4-hydroxy nimesulide effects on mitochondria and HepG2 cells. A comparison with nimesulide.

  European journal of pharmacology 20070702

• Thrombin inhibits migration of human hepatic myofibroblasts.

  American journal of physiology. Gastrointestinal and liver physiology 20070701

• Tolerance to coxibs in patients with intolerance to non-steroidal anti-inflammatory drugs (NSAIDs): a systematic structured review of the literature.

  Archives of dermatological research 20070701

• Survivin is a downstream target and effector of sulindac-sensitive oncogenic Stat3 signalling in head and neck cancer.

  International journal of oral and maxillofacial surgery 20070701

• Supercritical antisolvent precipitation of nimesulide: preliminary experiments.

  Current drug delivery 20070701

• Risk of acute liver injury associated with the use of drugs: a multicentre population survey.

  Alimentary pharmacology & therapeutics 20070615

• STAT3 and COX-2 activation in the guinea-pig brain during fever induced by the Toll-like receptor-3 agonist polyinosinic:polycytidylic acid.

  Cell and tissue research 20070601

• Nimesulide--a new trigger of radiation recall reaction.

  Clinical oncology (Royal College of Radiologists (Great Britain)) 20070601

• Eicosanoid biosynthesis inhibitors increase the susceptibility of Lymantria dispar to nucleopolyhedrovirus LdMNPV.

  Journal of invertebrate pathology 20070601

• Nimesulide alters cell recruitment into mitosis in murine intestinal crypts without influencing the cell production rate.

  Digestive diseases and sciences 20070601

• Nimesulide-induced hepatotoxicity and fatal hepatic failure.

  Singapore medical journal 20070601

• Localization of cyclooxygenase-2 in mice testis and assessment of its possible role through suppressing its expression using nimesulide: a preferential cyclooxygenase-2 inhibitor.

  Prostaglandins, leukotrienes, and essential fatty acids 20070601

• 5-aminosalicylic acid in combination with nimesulide inhibits proliferation of colon carcinoma cells in vitro.

  World journal of gastroenterology 20070528

• Tablet formulation studies on nimesulide and meloxicam-cyclodextrin binary systems.

  AAPS PharmSciTech 20070511

• Physicochemical profile of nimesulide. Exploring the interplay of lipophilicity, solubility and ionization.

  Journal of pharmaceutical and biomedical analysis 20070509

• Localization of cyclooxygenase-2 in mice vas deferens and its effects on fertility upon suppression using nimesulide: a preferential cyclooxygenase-2 inhibitor.

  Toxicology 20070505

• Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats.

  Naunyn-Schmiedeberg's archives of pharmacology 20070501

• Aspirin and COX-2 inhibitor nimesulide potentiate adrenergic contractions of human gastroepiploic artery.

  American journal of hypertension 20070501

• Rat ovulation, implantation and decidualization are severely compromised by COX-2 inhibitors.

  Frontiers in bioscience : a journal and virtual library 20070501

• Synthesis and biological evaluation of selective aromatase expression regulators in breast cancer cells.

  Journal of medicinal chemistry 20070405

• Characterizing new users of NSAIDs before and after rofecoxib withdrawal.

  British journal of clinical pharmacology 20070401

• Pharmacokinetics and bioavailability of nimesulide in goats.

  Journal of veterinary pharmacology and therapeutics 20070401

• Ethanol-mediated oxidative changes in blood lipids and proteins are reversed by aspirin-like drugs.

  Archives of medical research 20070401

• Blockade of p38 mitogen-activated protein kinase pathway ameliorates delayed intestinal transit in burned rats.

  American journal of surgery 20070401

• Increased tumor necrosis factor-alpha and prostaglandin E2 concentrations in the cerebrospinal fluid of rats with inflammatory hyperalgesia: the effects of analgesic drugs.

  Anesthesia and analgesia 20070401

• Inhibition of cAMP-dependent protein kinase A: a novel cyclo-oxygenase-independent effect of non-steroidal anti-inflammatory drugs in adipocytes.

  Autonomic & autacoid pharmacology 20070401

• Interaction between cyclooxygenase (COX)-1- and COX-2-products modulates COX-2 expression in the late phase of acute inflammation.

  European journal of pharmacology 20070322

• Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors.

  Bioorganic & medicinal chemistry 20070315

• Validated high-throughput HPLC assay for nimesulide using a short monolithic column.

  Journal of pharmaceutical and biomedical analysis 20070312

• High-performance liquid chromatography analysis of anti-inflammatory pharmaceuticals with ultraviolet and electrospray-mass spectrometry detection in suspected counterfeit homeopathic medicinal products.

  Journal of pharmaceutical and biomedical analysis 20070312

• Cyclooxygenase-2 mediates the sensitizing effects of systemic IL-1-beta on excitotoxic brain lesions in newborn mice.

  Neurobiology of disease 20070301

• Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol.

  British journal of pharmacology 20070301

• Short-term efficacy of rofecoxib and diclofenac in acute shoulder pain: a placebo-controlled randomized trial.

  PLoS clinical trials 20070301

• Oral and intravenous administration of nimesulide in the horse: rational dosage regimen from pharmacokinetic and pharmacodynamic data.

  Equine veterinary journal 20070301

• The effect of COX-2 inhibitor, nimesulide, on angiogenetic factors in primary endometrial carcinoma cell culture.

  Clinical and experimental medicine 20070301

• Hypoglycaemia in an infant with severe pulmonary hypertension after prenatal exposure to nimesulide: coincidence or side effect?

  Acta paediatrica (Oslo, Norway : 1992) 20070301

• Combination of cyclooxygenase-2 inhibitor and doxorubicin increases the growth inhibition and apoptosis in human hepatocellular carcinoma cells.

  Experimental oncology 20070301

• Protective role ofPhyllanthus niruri against nimesulide induced hepatic damage.

  Indian journal of clinical biochemistry : IJCB 20070301

• Additive interaction of intraperitoneal dexmedetomidine and topical nimesulide, celecoxib, and DFU for antinociception.

  European journal of pharmacology 20070205

• Selective cyclooxygenase-2 inhibitors stimulate glucose transport in L6 myotubes in a protein kinase Cdelta-dependent manner.

  Biochemical pharmacology 20070201

• Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats.

  Journal of neurochemistry 20070201

• Effect of different cyclooxygenase inhibitors on gastric adaptive cytoprotection induced by 20% ethanol.

  Digestive diseases and sciences 20070201

• Modulations in the intestinal disaccharide hydrolases and membrane dynamics: effect of non-steroidal anti-inflammatory drugs aspirin and nimesulide.

  Molecular and cellular biochemistry 20070101

• Ontogeny of chicken ductus arteriosus response to oxygen and vasoconstrictors.

  American journal of physiology. Regulatory, integrative and comparative physiology 20070101

• Co-administration of acetyl-11-keto-beta-boswellic acid, a specific 5-lipoxygenase inhibitor, potentiates the protective effect of COX-2 inhibitors in kainic acid-induced neurotoxicity in mice.

  Pharmacology 20070101

• Pharmacodynamic of cyclooxygenase inhibitors in humans.

  Prostaglandins & other lipid mediators 20070101

• Unaltered hepatic oxidative phosphorylation and mitochondrial permeability transition in wistar rats treated with nimesulide: Relevance for nimesulide toxicity characterization.

  Journal of biochemical and molecular toxicology 20070101

• Amelioration of galactosamine-induced nephrotoxicity by a protein isolated from the leaves of the herb, Cajanus indicus L.

  BMC complementary and alternative medicine 20070101

• Detection of serum histamine-releasing factors in a patient with idiopathic anaphylaxis and multiple drug allergy syndrome.

  Journal of investigational allergology & clinical immunology 20070101

• The role of cyclooxygenase in the feline pulmonary vascular bed.

  American journal of therapeutics 20070101

• Tocolytic effect of a selective FP receptor antagonist in rodent models reveals an innovative approach to the treatment of preterm labor.

  BMC pregnancy and childbirth 20070101

• A translational approach to studying preterm labour.

  BMC pregnancy and childbirth 20070101

• Reduced risk of human lung cancer by selective cyclooxygenase 2 (COX-2) blockade: results of a case control study.

  International journal of biological sciences 20070101

• Retrograde endocannabinoid inhibition of goldfish retinal cones is mediated by 2-arachidonoyl glycerol.

  Visual neuroscience 20070101

• Adenovirus type 5 E1A-induced apoptosis in COX-2-overexpressing breast cancer cells.

  Breast cancer research : BCR 20070101

• Acetaminophen, phenacetin and dipyrone do not modulate pressor responses to arachidonic Acid or to pressor agents.

  Pharmacology 20070101

• Inflammation and breast cancer. Cyclooxygenase/prostaglandin signaling and breast cancer.

  Breast cancer research : BCR 20070101

• Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.

  BMC neuroscience 20070101

• Evaluation of the prevalence and economic burden of adverse drug reactions presenting to the medical emergency department of a tertiary referral centre: a prospective study.

  BMC clinical pharmacology 20070101

• [Comparison of the time to analgetic and anti-inflammatory effect in the treatment of gouty arthritis with nimesulide and sodium diclofenac].

  Terapevticheskii arkhiv 20070101

• Exploring effects of different nonsteroidal antiinflammatory drugs on lipid peroxidation. Part II. 4-HNE profile.

  Acta poloniae pharmaceutica 20070101

• Cross-regulation of iNOS and COX-2 by its products in murine macrophages under stress conditions.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

• Molecular analysis of xenograft models of human cancer cachexia--possibilities for therapeutic intervention.

  Cancer genomics & proteomics 20070101

• Quantitation of nimesulide in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection and its application to a bioequivalence study.

  Arzneimittel-Forschung 20070101

• Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma.

  Prostaglandins, leukotrienes, and essential fatty acids 20070101

• [Nimesulide].

  Terapevticheskii arkhiv 20070101

• Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia.

  Journal of neuroinflammation 20070101

• Intestinal toxicity of non-steroidal anti-inflammatory drugs with differential cyclooxygenase inhibition selectivity.

  Nutricion hospitalaria 20070101

• [Nimesulide spectrophotometric determination in the visible region].

  Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20070101

• Comment on the in vitro and in vivo effects of nimesulide on liver mitochondria.

  Journal of biochemical and molecular toxicology 20070101

• Effect of cyclooxygenase on 'window of implantation' in mouse.

  Prostaglandins, leukotrienes, and essential fatty acids 20070101

• Alterations in the lipid profile and membrane dynamics of rat intestinal brush border membrane induced by different classes of nonsteroidal anti-inflammatory drugs.

  Toxicology mechanisms and methods 20070101

• Nonsteroidal anti-inflammatory drug hypersensitivity in preschool children.

  Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20070101

• Clinical management of adult patients with a history of nonsteroidal anti-inflammatory drug-induced urticaria/angioedema: update.

  Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20070101

• Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: Possible mechanism of action.

  Progress in neuro-psychopharmacology & biological psychiatry 20061230

• Design and synthesis of 3,4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: new lead-agents with analgesic and antipyretic properties.

  Bioorganic & medicinal chemistry 20061201

• Structure-based pharmacophore of COX-2 selective inhibitors and identification of original lead compounds from 3D database searching method.

  European journal of medicinal chemistry 20061201

• Effects of isopropyl palmitate on the skin permeation of drugs.

  Biological & pharmaceutical bulletin 20061101

• Anti-ischemic effects of nimesulide, a cyclooxygenase-2 inhibitor on the ischemic model of rabbit induced by isoproterenol.

  Archives of pharmacal research 20061101

• Acute generalized exanthematous pustulosis induced by nimesulide.

  Dermatology online journal 20061031

• Tolerance to celecoxib in patients with a history of adverse reactions to nonsteroidal anti-inflammatory drugs.

  Swiss medical weekly 20061028

• PGE2 up-regulates EGF-like growth factor biosynthesis in human granulosa cells: new insights into the coordination between PGE2 and LH in ovulation.

  Molecular human reproduction 20061001

• Cyclooxygenase-2 inhibitor, nimesulide, improves radiation treatment against non-small cell lung cancer both in vitro and in vivo.

  Oncology reports 20061001

• The effects of meperidine in the pulmonary vascular bed of the cat.

  Journal of cardiothoracic and vascular anesthesia 20061001

• Bioactivation and hepatotoxicity of nitroaromatic drugs.

  Current drug metabolism 20061001

• Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents.

  Current drug metabolism 20061001

• Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo.

  Indian journal of biochemistry & biophysics 20061001

• Status of mastitis as an emerging disease in improved and periurban dairy farms in India.

  Annals of the New York Academy of Sciences 20061001

• Differential pulse voltammetric determination of nimesulide in pharmaceutical formulation and human serum at glassy carbon electrode modified by cysteic acid/CNTs base on electrochemical oxidation of L-cysteine.

  Journal of pharmaceutical and biomedical analysis 20060918

• The effects of surfactants on the dissolution profiles of poorly water-soluble acidic drugs.

  International journal of pharmaceutics 20060914

• Cyclooxygenase-2 inhibition normalizes arterial blood pressure in CYP1A1-REN2 transgenic rats with inducible ANG II-dependent malignant hypertension.

  American journal of physiology. Renal physiology 20060901

• Cellular and molecular bases of the initiation of fever.

  PLoS biology 20060901

• [The influence of nonsteroidal anti-inflammatory drugs on deaminase adenosine activity].

  Polskie Archiwum Medycyny Wewnetrznej 20060901

• Comparative toxicity studies in birds using nimesulide and diclofenac sodium.

  Environmental toxicology and pharmacology 20060901

• Topical anti-inflammatory activity of 2alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae.

  Bioorganic & medicinal chemistry 20060815

• Nimesulide-induced antipyresis in rats involves both cyclooxygenase-dependent and independent mechanisms.

  European journal of pharmacology 20060814

• Inverse genetic predisposition to colon versus lung carcinogenesis in mouse lines selected based on acute inflammatory responsiveness.

  Carcinogenesis 20060801

• Medication use for pediatric upper respiratory tract infections.

  Fundamental & clinical pharmacology 20060801

• Non-steroidal anti-inflammatory drug-related hepatic damage in France and Spain: analysis from national spontaneous reporting systems.

  Fundamental & clinical pharmacology 20060801

• Use of ketoprofen oral challenges to detect cross-reactors among patients with a history of aspirin-induced urticaria.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060801

• Hepatic disorders in patients treated with COX-2 selective inhibitors or nonselective NSAIDs: a case/noncase analysis of spontaneous reports.

  Clinical therapeutics 20060801

• Current status of the therapeutic uses and actions of the preferential cyclo-oxygenase-2 NSAID, nimesulide.

  Inflammopharmacology 20060801

• Neuroprotective agents for clinical trials in ALS: a systematic assessment.

  Neurology 20060711

• Bradykinin B2 receptor knockout mice are protected from thrombosis by increased nitric oxide and prostacyclin.

  Blood 20060701

• The anti-inflammatory drug, nimesulide (4-nitro-2-phenoxymethane-sulfoanilide), uncouples mitochondria and induces mitochondrial permeability transition in human hepatoma cells: protection by albumin.

  The Journal of pharmacology and experimental therapeutics 20060701

• NSAID use and the risk of hospitalization for first myocardial infarction in the general population: a nationwide case-control study from Finland.

  European heart journal 20060701

• Gastric mucosal cell model for estimating relative gastrointestinal toxicity of non-steroidal anti-inflammatory drugs.

  Prostaglandins, leukotrienes, and essential fatty acids 20060701

• Trypanosoma cruzi infection and/or administration of the nonsteroidal anti-inflammatory nimesulide increase the number of colonic crypts overexpressing metallothioneins in rat colon carcinogenesis.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20060701

• Chamazulene carboxylic acid and matricin: a natural profen and its natural prodrug, identified through similarity to synthetic drug substances.

  Journal of natural products 20060701

• Inhibition of human neuroblastoma in SCID mice by low-dose of selective Cox-2 inhibitor nimesulide.

  Journal of neuro-oncology 20060601

• Steroid therapy for a case of severe drug-induced cholestasis.

  The Annals of pharmacotherapy 20060601

• The diffusion of nimesulide gel into synovial fluid: a comparison between administration routes.

  International journal of clinical pharmacology and therapeutics 20060601

• Nimesulide -- a multifactorial approach to inflammation and pain: scientific and clinical consensus.

  Current medical research and opinion 20060601

• Differential cell adhesion to vocal fold extracellular matrix constituents.

  Matrix biology : journal of the International Society for Matrix Biology 20060501

• Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress.

  Pathophysiology : the official journal of the International Society for Pathophysiology 20060501

• Dual, but not selective, COX-1 and COX-2 inhibitors, attenuate acetic acid-evoked bladder irritation in the anaesthetised female cat.

  British journal of pharmacology 20060501

• The effect of nitric oxide on the production of prostaglandin E2 by hydroxyapatite-stimulated a human osteoblast (HOS) cell line.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• The use of nimesulide and its analogues in cancer chemoprevention.

  Anti-cancer agents in medicinal chemistry 20060501

• Role of cyclooxygenase-2 in myocardial infarction and ischaemia.

  Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20060501

• Roles of cyclooxygenase 2 and microsomal prostaglandin E synthase 1 in rat acid reflux oesophagitis.

  Gut 20060401

• Effect of cyclooxygenase inhibitors on the micturition reflex in rats: correlation with inhibition of cyclooxygenase isozymes.

  BJU international 20060401

• Spectroscopic studies and life time measurements of binding of a bioactive compound to bovine serum albumin and the effects of common ions and other drugs on binding.

  Chemical & pharmaceutical bulletin 20060401

• Effect of cyclooxygenase-2 (COX-2) inhibitors in various animal models (bicuculline, picrotoxin, maximal electroshock-induced convulsions) of epilepsy with possible mechanism of action.

  Indian journal of experimental biology 20060401

• [Nonsteroidal antiinflammatory drugs and nitric oxide].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20060401

• Effect of glutamate receptor antagonists and antirheumatic drugs on proliferation of synoviocytes in vitro.

  European journal of pharmacology 20060327

• The effects of sufentanil in the feline pulmonary vascular bed.

  European journal of pharmacology 20060318

• Contribution of endothelin receptors and cyclooxygenase-derivatives to the altered response of the rabbit renal artery to endothelin-1 in diabetes.

  European journal of pharmacology 20060318

• Nimesulide inhibits lipopolysaccharide-induced production of superoxide anions and nitric oxide and iNOS expression in alveolar macrophages.

  Life sciences 20060306

• TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells.

  Biochemical and biophysical research communications 20060303

• An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies.

  Carcinogenesis 20060301

• Kynurenic acid, an endogenous constituent of rheumatoid arthritis synovial fluid, inhibits proliferation of synoviocytes in vitro.

  Rheumatology international 20060301

• COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals.

  Lung cancer (Amsterdam, Netherlands) 20060301

• Cyclooxygenase-2 (PTGS2) inhibitors augment the rate of hexose transport in L6 myotubes in an insulin- and AMPKalpha-independent manner.

  Diabetologia 20060301

• Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain.

  Pain 20060301

• Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer.

  Cancer research 20060215

• COX inhibitors and breast cancer.

  British journal of cancer 20060213

• A new medium-term rat colon bioassay applying neoplastic lesions as endpoints for detection of carcinogenesis modifiers-validation with known modifiers.

  Cancer letters 20060208

• Renal tubular dysgenesis associated with in utero exposure to Nimuselide.

  Pediatric nephrology (Berlin, Germany) 20060201

• Inhibition of cyclooxygenase as potential novel therapeutic strategy in N141I presenilin-2 familial Alzheimer's disease.

  Molecular psychiatry 20060201

• The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells.

  International journal of molecular medicine 20060201

• Etodolac, a selective cyclooxygenase-2 inhibitor, inhibits liver metastasis of colorectal cancer cells via the suppression of MMP-9 activity.

  International journal of molecular medicine 20060201

• Prostaglandin-H-synthase (PGHS)-1 and -2 microtiter assays for the testing of herbal drugs and in vitro inhibition of PGHS-isoenzyms by polyunsaturated fatty acids from Platycodi radix.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20060201

• Nimesulide-induced hepatic mitochondrial injury in heterozygous Sod2(+/-) mice.

  Free radical biology & medicine 20060201

• Nimesulide oral administration increases the intraocular pressure-lowering effect of latanoprost in patients with primary open-angle glaucoma.

  American journal of ophthalmology 20060201

• Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20060201

• Ocular adverse effects associated with cyclooxygenase-2 inhibitors.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20060201

• Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid.

  Indian journal of experimental biology 20060201

• [Clinical observation on treatment of rheumatoid arthritis with biqi capsule].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20060201

• [The influence of selected nonsteroidal anti-inflammatory drugs on antioxidative enzymes activity].

  Polskie Archiwum Medycyny Wewnetrznej 20060201

• Pityriasis rosea-like adverse reaction: review of the literature and experience of an Italian drug-surveillance center.

  Dermatology online journal 20060127

• Role of Tyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitor interactions in prostaglandin H synthase-2.

  Biochemistry 20060117

• Facilitated column selection in pharmaceutical analyses using a simple column classification system.

  Journal of chromatography. A 20060106

• Simultaneous quantitation of etoricoxib, salicylic acid, valdecoxib, ketoprofen, nimesulide and celecoxib in plasma by high-performance liquid chromatography with UV detection.

  Biomedical chromatography : BMC 20060101

• Differential expression and regulation of cylooxygenases, prostaglandin E synthases and prostacyclin synthase in rat uterus during the peri-implantation period.

  Reproduction (Cambridge, England) 20060101

• COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord.

  BMC neurology 20060101

• Differential modulation of ovine fetal ACTH secretion by PGHS-1 and PGHS-2.

  Neuroendocrinology 20060101

• Adverse reactions induced by NSAIDs and antibacterials: analysis of spontaneous reports from the Sicilian regional database.

  Drug safety 20060101

• Inhibition of NF-kappaB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia.

  Journal of neuroinflammation 20060101

• Anti-inflammatory and immunosuppressive drugs and reproduction.

  Arthritis research & therapy 20060101

• Human pregnancy safety for agents used to treat rheumatoid arthritis: adequacy of available information and strategies for developing post-marketing data.

  Arthritis research & therapy 20060101

• Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression.

  BMC cancer 20060101

• [Functional indices in assessment of gonarthrosis treatment efficacy with structum and chondrolon].

  Terapevticheskii arkhiv 20060101

• Effects of bisphosphonates on prostaglandin E2 and thromboxane B2 production in human whole blood and monocytes stimulated by lipopolysaccharide and A23187.

  Methods and findings in experimental and clinical pharmacology 20060101

• Re: double blind clinical trial comparing the safety and efficacy of nimesulide. (100mg) and diclofenac in osteoarthrosis of the hip and knee joints.

  West African journal of medicine 20060101

• Hyperacute fulminant fungal peritonitis and ascites in a HIV-infected patient with HCV-related, compensated liver cirrhosis. A supportive role for prolonged nimesulide self-administration.

  Enfermedades infecciosas y microbiologia clinica 20060101

• Plasma and synovial fluid concentrations of nimesulide and its main metabolite after a single or repeated oral administration in patients with knee osteoarthritis.

  The Journal of international medical research 20060101

• Bilateral spontaneous hemotympanum: case report.

  Head & face medicine 20060101

• Analysis of the effects of fentanyl in the feline pulmonary vascular bed.

  American journal of therapeutics 20060101

• Effects of non steroidal anti-inflammatory drugs on the antioxidant defense system and the membrane functions in the rat intestine.

  Nutricion hospitalaria 20060101

• Parecoxib is neuroprotective in spontaneously hypertensive rats after transient middle cerebral artery occlusion: a divided treatment response?

  Journal of neuroinflammation 20060101

• Use of nonsteroidal anti-inflammatory drugs in patients with aspirin hypersensitivity : safety of cyclo-oxygenase-2 inhibitors.

  Treatments in respiratory medicine 20060101

• Exploring effects of different nonsteroidal antiinflammatory drugs on malondialdehyde profile.

  Acta poloniae pharmaceutica 20060101

• The endocannabinoid arachidonyl ethanolamide (anandamide) increases pulmonary arterial pressure via cyclooxygenase-2 products in isolated rabbit lungs.

  American journal of physiology. Heart and circulatory physiology 20051201

• A new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide.

  European journal of medicinal chemistry 20051201

• The effect of nimesulide, a selective cyclooxygenase-2 inhibitor, on Ets-1 and Ets-2 expression in head and neck cancer cell lines.

  Head & neck 20051201

• Inhibition of cytotoxicity of cisplatin by cyclooxygenase-2 inhibitor nimesulide in head and neck cancer cell lines.

  Oncology reports 20051201

• Protective effect of cyclooxygenase-2 (COX-2) inhibitors but not non-selective cyclooxygenase (COX)-inhibitors on ethanol withdrawal-induced behavioural changes.

  Addiction biology 20051201

• A pharmacokinetic comparison of three pharmaceutical formulations of nimesulide in healthy volunteers.

  Vojnosanitetski pregled 20051201

• Semisolid topical formulations containing nimesulide-loaded nanocapsules, nanospheres or nanoemulsion: development and rheological characterization.

  Die Pharmazie 20051201

• A woman with rheumatoid arthritis whose condition did not improve during pregnancy.

  Nature clinical practice. Rheumatology 20051201

• Hydrogel stamping of arrays of supported lipid bilayers with various lipid compositions for the screening of drug-membrane and protein-membrane interactions.

  Angewandte Chemie (International ed. in English) 20051021

• Vasoactive prostanoids are generated from arachidonic acid by COX-1 and COX-2 in the mouse.

  American journal of physiology. Heart and circulatory physiology 20051001

• Mitochondrial permeability transition as a source of superoxide anion induced by the nitroaromatic drug nimesulide in vitro.

  Free radical biology & medicine 20051001

• Efficacy of a fixed combination of indomethacin, prochlorperazine, and caffeine in the treatment of episodic tension-type headache: a double-blind, randomized, nimesulide-controlled, parallel group, multicentre trial.

  European journal of neurology 20051001

• [Transient right ventricular hypertrophy in a newborn infant exposed in utero to nimesulide].

  Minerva pediatrica 20051001

• An overview of the recent developments in analytical methodologies for determination of COX-2 inhibitors in bulk drugs, pharmaceuticals and biological matrices.

  Journal of pharmaceutical and biomedical analysis 20050915

• COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites.

  International journal of cancer 20050910

• In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I.

  Bioorganic & medicinal chemistry letters 20050901

• The influence of anti-inflammatory drugs on the proliferation of fibroblast derived from nasal polyps.

  Auris, nasus, larynx 20050901

• Mechanism of interaction of the non-steroidal antiinflammatory drugs meloxicam and nimesulide with serum albumin.

  Journal of pharmaceutical and biomedical analysis 20050901

• Analgesic synergism between intrathecal morphine and cyclooxygenase-2 inhibitors in mice.

  Pharmacology, biochemistry, and behavior 20050901

• Multiple enterocolic perforations and their possible association with prolonged intake of nimesulide: report of two cases.

  Digestive diseases and sciences 20050901

• Protective effects of nimesulide (COX Inhibitor), AKBA (5-LOX Inhibitor), and their combination in aging-associated abnormalities in mice.

  Methods and findings in experimental and clinical pharmacology 20050901

• A questionnaire-based study on prevalence and treatment of headache in young children.

  The journal of headache and pain 20050901

• Symptomatic treatment of migraine in children: a systematic review of medication trials.

  Pediatrics 20050801

• Involvement of endothelial cyclo-oxygenase metabolites in noradrenaline-induced contraction of rat coronary artery.

  Clinical and experimental pharmacology & physiology 20050801

• [The effect of selective cyclooxygenase-2 inhibitor nimesulide on breast cancer induced by dimethylbenzoic acid in rats].

  Zhonghua wai ke za zhi [Chinese journal of surgery] 20050801

• Selection of topically applied non-steroidal anti-inflammatory drugs for oral cancer chemoprevention.

  Oral oncology 20050701

• Comparative gastrointestinal toxicity of selective cyclooxygenase (COX-2) inhibitors.

  Indian journal of experimental biology 20050701

• Long-term use and tolerability of cyclooxygenase-2 inhibitors in patients with analgesic intolerance.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050701

• COX-2-derived prostacyclin modulates vascular remodeling.

  Circulation research 20050624

• The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2.

  Rheumatology international 20050601

• Development and validation of a reversed-phase liquid chromatographic method for separation and simultaneous determination of COX-2 inhibitors in pharmaceuticals and its application to biological fluids.

  Biomedical chromatography : BMC 20050601

• Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by raloxifene, an antiestrogen with anti-androgen action, but not nimesulide, a selective cyclooxygenase-2 inhibitor.

  Carcinogenesis 20050601

• Cyclooxygenase-2 inhibitors attenuate angiotensin II-induced oxidative stress, hypertension, and cardiac hypertrophy in rats.

  Hypertension (Dallas, Tex. : 1979) 20050601

• Oral aspirin challenges in patients with a history of intolerance to single non-steroidal anti-inflammatory drugs.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20050601

• Possible analgesic and anti-inflammatory interactions of aspartame with opioids and NSAIDs.

  Indian journal of experimental biology 20050601

• Comparative study of rules employed for calculation of pediatric drug dosage.

  Journal of applied oral science : revista FOB 20050601

• Nimesulide PLA microspheres as a potential sustained release system for the treatment of inflammatory diseases.

  International journal of pharmaceutics 20050513

• Roles of nitric oxide and prostaglandins in pathogenesis of delayed colonic transit after burn injury in rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20050501

• Safety of celecoxib in patients with adverse reactions to nimesulide.

  Allergy 20050501

• Does reduction of circulating prostaglandin E2 reduce fetal hypothalamic-pituitary-adrenal axis activity?

  Journal of the Society for Gynecologic Investigation 20050501

• Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer.

  The Journal of steroid biochemistry and molecular biology 20050501

• Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.

  Journal of medicinal chemistry 20050407

• Stimulation of protease-activated receptor-2 inhibits airway eosinophilia, hyperresponsiveness and bronchoconstriction in a murine model of allergic inflammation.

  British journal of pharmacology 20050401

• Severe ductal constriction in the third-trimester fetus following maternal self-medication with nimesulide.

  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 20050401

• Design, development and optimization of nimesulide-loaded liposomal systems for topical application.

  Current drug delivery 20050401

• Self-emulsifying pellets prepared by wet granulation in high-shear mixer: influence of formulation variables and preliminary study on the in vitro absorption.

  International journal of pharmaceutics 20050303

• Are prostanoids related to positive inotropism by UTP and ATP?

  Pharmacology 20050301

• A factor analysis for complex systems containing nimesulide.

  Journal of pharmaceutical sciences 20050301

• Augmentation of allergic inflammation in the airways of cyclooxygenase-2-deficient mice.

  Respirology (Carlton, Vic.) 20050301

• COX-2 selective nonsteroidal anti-inflammatory drugs: current status.

  The Journal of the Association of Physicians of India 20050301

• Simultaneous LC determination of tizanidine and rofecoxib in tablets.

  Journal of pharmaceutical and biomedical analysis 20050207

• Nimesulide, a COX-2 inhibitor, does not reduce lesion size or number in a nude mouse model of endometriosis.

  Human reproduction (Oxford, England) 20050201

• In vivo endothelial interaction between ACE and COX inhibitors.

  Prostaglandins, leukotrienes, and essential fatty acids 20050201

• Expression levels of Akt in nimesulide-treated squamous carcinoma cell lines of the head and neck.

  Oncology reports 20050201

• Capillary zone electrophoresis for simultaneous determination of seven nonsteroidal anti-inflammatory drugs in pharmaceuticals.

  Analytical and bioanalytical chemistry 20050201

• Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor.

  Cancer research 20050201

• Safety of celecoxib in patients with adverse skin reactions to acetaminophen (paracetamol) and nimesulide associated or not with common non-steroidal anti-inflammatory drugs.

  European annals of allergy and clinical immunology 20050201

• Rofecoxib for osteoarthritis.

  The Cochrane database of systematic reviews 20050125

• Effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on cardiovascular alterations in endotoxemia.

  Cardiology 20050101

• Subjective impact of osteoarthritis flare-ups on patients' quality of life.

  Health and quality of life outcomes 20050101

• Reversal of LPS-induced central and peripheral hyperalgesia by green tea extract.

  Phytotherapy research : PTR 20050101

• Effect of rofecoxib on antihypertensive effects of candesartan in experimental models of hypertension.

  Methods and findings in experimental and clinical pharmacology 20050101

• The effects of non-steroidal anti-inflammatory drugs (selective and non-selective) on the treatment of periodontal diseases.

  Current pharmaceutical design 20050101

• Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands.

  BMC cancer 20050101

• Detection of nimesulide metabolites in rat plasma and hepatic subcellular fractions by HPLC-UV/DAD and LC-MS/MS studies.

  European journal of drug metabolism and pharmacokinetics 20050101

• Double blind clinical trial comparing the safety and efficacy of nimesulide (100mg) and diclofenac in osteoarthrosis of the hip and knee joints.

  West African journal of medicine 20050101

• Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis.

  Drugs in R&D 20050101

• Pulmonary infiltrates with eosinophilia induced by nimesulide in an asthmatic patient.

  Respiration; international review of thoracic diseases 20050101

• The pathophysiological function of peroxisome proliferator-activated receptor-gamma in lung-related diseases.

  Respiratory research 20050101

• Erosive pustular dermatosis of the scalp: a case report and review of the literature.

  Dermatology (Basel, Switzerland) 20050101

• Serum deprivation and re-addition: effects on cyclooxygenase inhibitor sensitivity in cultured glia.

  Inflammopharmacology 20050101

• Comparative study of anti-inflammatory and ulcerogenic activities of different cyclo-oxygenase inhibitors.

  Inflammopharmacology 20050101

• Nimesulide-induced fixed drug eruption.

  Allergologia et immunopathologia 20050101

• Effect of two non-steroidal anti-inflammatory drugs, aspirin and nimesulide on the D-glucose transport and disaccharide hydrolases in the intestinal brush border membrane.

  Pharmacological reports : PR 20050101

• Transient renal failure in twins with maternal Cox-1/Cox-2 use in pregnancy.

  Irish medical journal 20050101

• Teaching exercise of drug utilization by medical students.

  JNMA; journal of the Nepal Medical Association 20050101

• New aspects of cyclooxygenase-2 inhibition in myocardial infarction and ischaemia.

  Research communications in molecular pathology and pharmacology 20050101

• Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors.

  Journal of medicinal chemistry 20041230

• Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells.

  Cancer gene therapy 20041201

• Pattern of NSAID use in the Italian general population: a questionnaire-based survey.

  European journal of clinical pharmacology 20041201

• Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease.

  The American journal of pathology 20041201

• The selective cyclooxygenase-2 inhibitor nimesulide prevents Helicobacter pylori-associated gastric cancer development in a mouse model.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20041201

• Treatment of de Quervain disease with triamcinolone injection with or without nimesulide. A randomized, double-blind, placebo-controlled trial.

  The Journal of bone and joint surgery. American volume 20041201

• PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology.

  Journal of veterinary pharmacology and therapeutics 20041201

• Effect of nimesulide co-administration on pharmacokinetics of lithium.

  Indian journal of experimental biology 20041201

• Characterisation of nimesulide-betacyclodextrins systems prepared by supercritical fluid impregnation.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20041101

• Nimesulide and indomethacin induce apoptosis in head and neck cancer cells.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20041101

• Plant phenolic 4-coumaric acid protects against intestinal inflammation in rats.

  Scandinavian journal of gastroenterology 20041101

• Docking studies on NSAID/COX-2 isozyme complexes using contact statistics analysis.

  Journal of computer-aided molecular design 20041101

• [Acute hepatitis after use of nimesulide: drug-induced or is there something more? Mononucleosis].

  Praxis 20041020

• Neonatal chronic renal failure associated with maternal ingestion of Nimesulide as analgesic.

  European journal of obstetrics, gynecology, and reproductive biology 20041015

• Synthetic and naturally occurring COX-2 inhibitors suppress proliferation in a human oesophageal adenocarcinoma cell line (OE33) by inducing apoptosis and cell cycle arrest.

  Carcinogenesis 20041001

• Analgesic use in dentistry in a tertiary hospital in western Nepal.

  Pharmacoepidemiology and drug safety 20041001

• Self-reported drug allergy in a general adult Portuguese population.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20041001

• Effect of nimesulide on the serum levels of hyaluronan and stromelysin-1 in patients with osteoarthritis: a pilot study.

  International journal of clinical practice. Supplement 20041001

• How important is the role of the physician in the correct use of a drug? An observational cohort study in general practice.

  International journal of clinical practice. Supplement 20041001

• Isobolographic analysis of the antinociceptive interactions of clonidine with nonsteroidal anti-inflammatory drugs.

  Pharmacological research 20040901

• Arachidonic acid-induced carbon-centered radicals and phospholipid peroxidation in cyclo-oxygenase-2-transfected PC12 cells.

  Journal of neurochemistry 20040901

• Reversal of LPS-induced immobility in mice by green tea polyphenols: possible COX-2 mechanism.

  Phytotherapy research : PTR 20040901

• Formulation design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique.

  AAPS PharmSciTech 20040901

• In vitro comparative assessment of the scavenging activity against three reactive oxygen species of non-steroidal anti-inflammatory drugs from the oxicam and sulfoanilide families.

  European journal of pharmacology 20040802

• Effect of peritonitis on gallbladder smooth muscle contractility in guinea pigs.

  The Journal of surgical research 20040801

• Aspirin and NSAID sensitivity.

  Immunology and allergy clinics of North America 20040801

• PAF is involved in the Mycoplasma arthritidis superantigen-triggering pathway for iNOS and COX-2 expression in murine peritoneal cells.

  Experimental cell research 20040801

• First and second generations of COX-2 selective inhibitors.

  Mini reviews in medicinal chemistry 20040801

• Cyclooxygenase-2 is a possible target of treatment approach in conjunction with photodynamic therapy for various disorders in skin and oral cavity.

  The British journal of dermatology 20040801

• Immune tolerance to drugs. (II).: Long-term tolerability of nimesulide in patients with NSAID hypersensitivity.

  Immunopharmacology and immunotoxicology 20040801

• Lipopolysaccharide-induced paw edema model for detection of cytokine modulating anti-inflammatory agents.

  International immunopharmacology 20040701

• Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus.

  Nature neuroscience 20040701

• Effects of cyclooxygenase 2 inhibitors on biological traits of nasopharyngeal carcinoma cells.

  Acta pharmacologica Sinica 20040701

• Enhanced release of prostaglandin D2 during re-incubation of RAW 264.7 macrophage-like cells after treatment of both lipopolysaccharide and non-steroidal anti-inflammatory drugs.

  Biological & pharmaceutical bulletin 20040701

• Attitudes and concerns of French veterinarians towards pain and analgesia in dogs and cats.

  Veterinary anaesthesia and analgesia 20040701

• [Effect of cyclooxygenase-2 inhibitor, nimesulide, combined with cisplatin on lung cancer].

  Zhongguo fei ai za zhi = Chinese journal of lung cancer 20040620

• Opposing effects of cyclooxygenase-2 selective inhibitors on oxygen-glucose deprivation-induced neurotoxicity.

  European journal of pharmacology 20040616

• Preoptic alpha 1- and alpha 2-noradrenergic agonists induce, respectively, PGE2-independent and PGE2-dependent hyperthermic responses in guinea pigs.

  American journal of physiology. Regulatory, integrative and comparative physiology 20040601

• Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver.

  Biochemical pharmacology 20040601

• Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs.

  American journal of veterinary research 20040601

• Cyclooxygenase-2 inhibitor nimesulide suppresses telomerase activity by blocking Akt/PKB activation in gastric cancer cell line.

  Digestive diseases and sciences 20040601

• Rapid determination of nimesulide in rabbit aqueous humor by liquid chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040525

• Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat.

  Brain research 20040508

• Prescribing habits of general practitioners in the treatment of childhood respiratory-tract infections.

  European journal of clinical pharmacology 20040501

• TNF-alpha hyperpolarizes membrane potential and potentiates the response to nicotinic receptor stimulation in cultured rat myenteric neurones.

  Acta physiologica Scandinavica 20040501

• Headache treatment before and after the consultation of a specialized centre: a pharmacoepidemiology study.

  Cephalalgia : an international journal of headache 20040501

• Regulatory role of vHL/HIF-1alpha in hypoxia-induced VEGF production in hepatic stellate cells.

  Biochemical and biophysical research communications 20040430

• Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice.

  International journal of cancer 20040420

• Comparison of the effects of nimesulide and 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl) phenyl-2(5H)-furanone (DFU) on contractions of isolated pregnant human myometrium.

  European journal of obstetrics, gynecology, and reproductive biology 20040415

• Hydrotropic solubilization of nimesulide for parenteral administration.

  International journal of pharmaceutics 20040415

• The regulation of interleukin-6 secretion by prostanoids and members of the tumor necrosis factor superfamily in fresh villous fragments of term human placenta.

  Journal of the Society for Gynecologic Investigation 20040401

• Nonsteroidal anti-inflammatory drug-induced liver injury: a case-control study in primary care.

  Fundamental & clinical pharmacology 20040401

• Spinal prostaglandin formation and pain perception following thoracotomy: a role for cyclooxygenase-2.

  Chest 20040401

• Comment on efficacy of rofecoxib and nimesulide in controlling post-extraction pain in oral surgery: a randomised comparative study.

  Current medical research and opinion 20040401

• Experience of the use of nimesulide, a cyclo-oxygenase-2 selective prostaglandin synthesis inhibitor, in the prevention of preterm labour in 44 high-risk cases.

  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20040401

• [Nimesulide, a selective cyclooxygenase-2 inhibitor inhibits telomerase activity by blocking activation of PKB in gastric cancer cell line].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20040401

• In vitro nimesulide absorption from different formulations.

  Journal of pharmaceutical sciences 20040301

• Role of cyclooxygenase in ventricular effects of adrenomedullin: is adrenomedullin a double-edged sword in sepsis?

  American journal of physiology. Heart and circulatory physiology 20040301

• Risk factors of adverse drug reaction from non-steroidal anti-inflammatory drugs in Shanghai patients with arthropathy.

  Acta pharmacologica Sinica 20040301

• Physiological induction of transient receptor potential canonical proteins, calcium entry channels, in human myometrium: influence of pregnancy, labor, and interleukin-1 beta.

  The Journal of clinical endocrinology and metabolism 20040301

• Prolonged ECT seizure in a patient taking Nimesulide.

  The journal of ECT 20040301

• The reactions of oxicam and sulfoanilide non steroidal anti-inflammatory drugs with hypochlorous acid: determination of the rate constants with an assay based on the competition with para-aminobenzoic acid chlorination and identification of some oxidation products.

  Free radical research 20040301

• Optimal suppression of thromboxane A(2) formation by aspirin during percutaneous transluminal coronary angioplasty: no additional effect of a selective cyclooxygenase-2 inhibitor.

  Journal of the American College of Cardiology 20040218

• Cyclooxygenase inhibition in patients with coronary artery disease.

  Journal of the American College of Cardiology 20040218

• Identification of Tyr504 as an alternative tyrosyl radical site in human prostaglandin H synthase-2.

  Biochemistry 20040217

• Antimitogenic effects of HDL and APOE mediated by Cox-2-dependent IP activation.

  The Journal of clinical investigation 20040215

• Effect of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of lung tumors and their expression of cyclooxygenase-2 and peroxisome proliferator- activated receptor-gamma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040215

• Comparison of effects of cyclooxygenase inhibitors on myometrial contraction and constriction of ductus arteriosus in rats.

  European journal of pharmacology 20040206

• Detergents profoundly affect inhibitor potencies against both cyclo-oxygenase isoforms.

  The Biochemical journal 20040201

• Nimesulide, a cyclooxygenase-2 preferential inhibitor, impairs renal function in the newborn rabbit.

  Pediatric research 20040201

• In utero exposure to nonsteroidal anti-inflammatory drugs: neonatal renal failure.

  Pediatric nephrology (Berlin, Germany) 20040201

• Evaluation of the Malvern Spraytec with inhalation cell for the measurement of particle size distribution from metered dose inhalers.

  Journal of pharmaceutical sciences 20040201

• Mechanisms of lipopolysaccharide-induced changes in effects of contractile agonists on pregnant rat myometrium.

  American journal of obstetrics and gynecology 20040201

• Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2.

  Immunology and cell biology 20040201

• Safety of selective COX-2 inhibitors in aspirin/nonsteroidal anti-inflammatory drug-intolerant patients: comparison of nimesulide, meloxicam, and rofecoxib.

  The Journal of asthma : official journal of the Association for the Care of Asthma 20040201

• [Nimesulide: a lower risk treatment in rheumatic diseases].

  Vnitrni lekarstvi 20040201

• Amelioration of hippocampal neuronal damage after transient forebrain ischemia in cyclooxygenase-2-deficient mice.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20040101

• Comparison of nonselective cyclo-oxygenase (COX) inhibitor and selective COX-2 inhibitors on preimplantation loss, postimplantation loss and duration of gestation: an experimental study.

  Contraception 20040101

• Efficacy of rofecoxib and nimesulide in controlling postextraction pain in oral surgery: a randomised comparative study.

  Current medical research and opinion 20040101

• Effect of penetration enhancers on in vitro percutaneous penetration of nimesulide through rat skin.

  Die Pharmazie 20040101

• Symptomatic reversible duodenal compression due to iatrogenic retroperitoneal hematoma.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20040101

• The role and interactions of nitric oxide (NO), carbon monoxide (CO), and prostanoids in the pathogenesis of postoperative ileus in rats.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20040101

• Effects of aminoguanidine and cyclooxygenase inhibitors on nitric oxide and prostaglandin production, and nitric oxide synthase and cyclooxygenase expression induced by lipopolysaccharide in the estrogenized rat uterus.

  Neuroimmunomodulation 20040101

• Upper gastrointestinal bleeding associated with the use of NSAIDs: newer versus older agents.

  Drug safety 20040101

• Pain--the enigmatic entity.

  Journal of the Indian Medical Association 20040101

• The effects of nimesulide combined with cisplatin on lung cancer.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101

• Mucoadhesive tablets for buccal administration containing sodium nimesulide.

  Drug delivery 20040101

• Venous thromboembolism in pregnancy. A case report of deep venous thrombosis (DVT) in puerperium.

  Clinical and experimental obstetrics & gynecology 20040101

• [Naiz (nimesulid) in combined treatment of patients with chronic non-bacterial prostatitis with chronic pelvic pain syndrome].

  Urologiia (Moscow, Russia : 1999) 20040101

• [Non-steroidal anti-inflammatory drugs and tramadol in the treatment of osteoarthrosis deformans in patients with arterial hypertension].

  Klinicheskaia meditsina 20040101

• [Hepatotoxicity of nimesulide].

  Gaceta medica de Mexico 20040101

• Anti-inflammatory effects of selective COX-2 inhibitors.

  Polish journal of pharmacology 20040101

• Role of adrenal gland hormones in the mechanism of antiulcer action of nimesulide and ranitidine.

  Polish journal of pharmacology 20040101

• [The effectiveness and safety of nimesulide (nimesile) in patients with gouty arthritis].

  Klinicheskaia meditsina 20040101

• Crystallization of a non-steroidal anti-inflammatory drug from ethanol-water solution in presence of polymers: physicochemical characterization and release behaviour from suppositories.

  Acta poloniae pharmaceutica 20040101

• Effect of nimesulide-a preferential COX-2 inhibitor on arterial blood pressure, compared to ketoprofen.

  Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20040101

• Nimesulide prevents oxidative stress damage following transient forebrain ischemia in the rat hippocampus.

  Research communications in molecular pathology and pharmacology 20040101

• Nimesulide induced bullous fixed drug eruption of the labial mucosa.

  Indian journal of dermatology, venereology and leprology 20040101

• Liquid chromatographic determination of ceterizine hydrochloride and paracetamol in human plasma and pharmaceutical formulations.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031205

• Modulatory effect of cyclooxygenase inhibitors on sildenafil-induced antinociception.

  Pharmacology 20031201

• Determination of repaglinide in pharmaceutical formulations by HPLC with UV detection.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20031201

• Nimesulide and meloxicam are a safe alternative drugs for patients intolerant to nonsteroidal anti-inflammatory drugs.

  European annals of allergy and clinical immunology 20031201

• The risk of upper gastrointestinal bleeding in elderly users of aspirin and other non-steroidal anti-inflammatory drugs: the role of gastroprotective drugs.

  Aging clinical and experimental research 20031201

• [Management of postoperative inflammatory response and pain with nimesulide after cardiac surgery].

  Orvosi hetilap 20031130

• Flow amperometric determination of pharmaceuticals with on-line electrode surface renewal.

  Journal of pharmaceutical and biomedical analysis 20031124

• A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385.

  The Journal of biological chemistry 20031114

• How experimental design can improve the validation process. Studies in pharmaceutical analysis.

  Analytical and bioanalytical chemistry 20031101

• Arachidonic acid cascade inhibitors modulate phorbol ester-induced oxidative stress in female ICR mouse skin: differential roles of 5-lipoxygenase and cyclooxygenase-2 in leukocyte infiltration and activation.

  Free radical biology & medicine 20031101

• Small risk ratios may have strong public health impact.

  BMJ (Clinical research ed.) 20031101

• Inhibition of cyclooxygenase-2 indirectly potentiates antitumor effects of photodynamic therapy in mice.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20031101

• Modification by nimesulide administration of the phagocytic activity of polymorphonuclears of healthy subjects.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20031101

• [Meta-analysis on the effect and adverse reaction on patients with osteoarthritis and rheumatoid arthritis treated with non-steroidal anti-inflammatory drugs].

  Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 20031101

• Role of COX-2 in the enhanced vasoconstrictor effect of arachidonic acid in the diabetic rat kidney.

  Hypertension (Dallas, Tex. : 1979) 20031001

• Suppressive effect of selective cyclooxygenase-2 inhibitor on cytokine release in human neutrophils.

  International immunopharmacology 20031001

• Prostaglandin inhibitors in preterm labour.

  Best practice & research. Clinical obstetrics & gynaecology 20031001

• Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination.

  Biochemical pharmacology 20031001

• Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils.

  Neuroscience research 20031001

• Nimesulide inhibits tumor growth in mice implanted hepatoma: overexpression of Bax over Bcl-2.

  Acta pharmacologica Sinica 20031001

• [Selective COX-2 inhibitor-associated colitis: two case reports].

  Gastroenterologie clinique et biologique 20031001

• Inhibitory effects of selective cyclooxygenase-2 inhibitors, nimesulide and etodolac, on the development of squamous cell dysplasias and carcinomas of the tongue in rats initiated with 4-nitroquinoline 1-oxide.

  Cancer letters 20030925

• Cyclooxygenase-2 (COX-2) inhibitors sensitize tumor cells specifically to death receptor-induced apoptosis independently of COX-2 inhibition.

  Oncogene 20030911

• Partition and location of nimesulide in EPC liposomes: a spectrophotometric and fluorescence study.

  Analytical and bioanalytical chemistry 20030901

• Lipopolysaccharide-induced dopaminergic cell death in rat midbrain slice cultures: role of inducible nitric oxide synthase and protection by indomethacin.

  Journal of neurochemistry 20030901

• Inhibition of neurokinin-1-substance P receptor and prostanoid activity prevents and reverses the development of morphine tolerance in vivo and the morphine-induced increase in CGRP expression in cultured dorsal root ganglion neurons.

  The European journal of neuroscience 20030901

• Evaluation of an aerosolized selective COX-2 inhibitor as a potentiator of doxorubicin in a non-small-cell lung cancer cell line.

  Pharmaceutical research 20030901

• Nimesulide-modified gum karaya solid mixtures: preparation, characterization, and formulation development.

  Drug development and industrial pharmacy 20030901

• Solubility enhancement of Cox-2 inhibitors using various solvent systems.

  AAPS PharmSciTech 20030901

• Nimesulide-induced fulminant hepatitis.

  The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 20030901

• Role of cyclooxygenase-2 in the generation of vasoactive prostanoids in the rat pulmonary and systemic vascular beds.

  Circulation 20030819

• The cyclooxygenase 2-specific nonsteroidal anti-inflammatory drugs celecoxib and nimesulide inhibit androgen receptor activity via induction of c-Jun in prostate cancer cells.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20030801

• IAP Committee for Protection of Child Consumer: statement on safety of nimesulide in children.

  Indian pediatrics 20030801

• Molecular mechanisms involved in the antiproliferative effect of two COX-2 inhibitors, nimesulide and NS-398, on colorectal cancer cell lines.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20030801

• Kikuchi-Fujimoto disease with lateral neck localisation: a case report.

  Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 20030801

• Nimesulide affects antioxidant status during acute lung inflammation in rats.

  Indian journal of biochemistry & biophysics 20030801

• Characterization of a quaternary liquid system improving the bioavailability of poorly water soluble drugs.

  Journal of colloid and interface science 20030715

• PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells.

  Biochemical and biophysical research communications 20030711

• Cohort study of hepatotoxicity associated with nimesulide and other non-steroidal anti-inflammatory drugs.

  BMJ (Clinical research ed.) 20030705

• The effects of non-steroidal anti-inflammatory compounds on human myometrial contractility.

  European journal of obstetrics, gynecology, and reproductive biology 20030701

• Characterization of two labor-induced genes, DSCR1 and TCTE1L, in the pregnant ovine myometrium.

  The Journal of endocrinology 20030701

• Penile Mondor's disease after intensive masturbation in a 31-and a 33-year-old man.

  Thrombosis and haemostasis 20030701

• Differential scanning calorimetry differences in micronized and unmicronized nimesulide uptake processes in biomembrane models.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030701

• Effect of nimesulide on acetic acid- and leukotriene-induced inflammatory bowel disease in rats.

  Prostaglandins & other lipid mediators 20030701

• Inducible brain COX-2 facilitates the recurrence of hippocampal seizures in mouse rapid kindling.

  Prostaglandins & other lipid mediators 20030701

• Expression of cyclooxygenase-2 in primary superficial bladder cancer tissue may predict risk of its recurrence after complete transurethral resection.

  Aktuelle Urologie 20030701

• Mechanisms of angiotensin-converting enzyme inhibitor induced thrombolysis in Wistar rats.

  Thrombosis research 20030615

• Fast separations on monolithic silica columns: method transfer, robustness and column ageing for some case studies.

  Journal of pharmaceutical and biomedical analysis 20030601

• Safety of oral use of nimesulide in children: systematic review of randomized controlled trials.

  Indian pediatrics 20030601

• Rational use of antipyretics.

  Indian pediatrics 20030601

• Study of solid lipid nanoparticles with respect to particle size distribution and drug loading.

  Die Pharmazie 20030601

• Hemicrania horologica ('clock-like hemicrania').

  Neurology 20030527

• Nimesulide inhibits proliferation via induction of apoptosis and cell cycle arrest in human gastric adenocarcinoma cell line.

  World journal of gastroenterology 20030515

• Synergistic effects of nimesulide and 5-fluorouracil on tumor growth and apoptosis in the implanted hepatoma in mice.

  World journal of gastroenterology 20030515

• Anhydramnios and maternal thrombocytopenia after prolonged use of nimesulide.

  European journal of obstetrics, gynecology, and reproductive biology 20030501

• Combinatorial effects of nonsteroidal anti-inflammatory drugs and food constituents on production of prostaglandin E2 and tumor necrosis factor-alpha in RAW264.7 murine macrophages.

  Bioscience, biotechnology, and biochemistry 20030501

• Does nimesulide induce haemolysis in glucose-6-phosphate dehydrogenase deficiency?

  Acta paediatrica (Oslo, Norway : 1992) 20030501

• Effect of selective vs. non-selective cyclo-oxygenase inhibitors on fetal membrane prostaglandin synthesis.

  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20030501

• A cyclooxygenase-2 inhibitor, nimesulide, inhibits postinitiation phase of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters.

  International journal of cancer 20030410

• Do altering in ornithine decarboxylase activity and gene expression contribute to antiproliferative properties of COX inhibitors?

  British journal of cancer 20030407

• Pharmaco-toxicological study of diterpenoids.

  Bioorganic & medicinal chemistry 20030403

• A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401

• Cyclooxygenase-2 inhibition improves macrophage function in melanoma and increases the antineoplastic activity of interferon gamma.

  Annals of surgical oncology 20030401

• Tolerance of nimesulide in NSAID intolerant patients.

  Allergy 20030401

• A double-blind randomized study of fetal side effects during and after the short-term maternal administration of indomethacin, sulindac, and nimesulide for the treatment of preterm labor.

  American journal of obstetrics and gynecology 20030401

• Use of nimesulide in Indian children must be stopped.

  BMJ (Clinical research ed.) 20030329

• Photochemical stability of nimesulide.

  Journal of pharmaceutical and biomedical analysis 20030326

• Nonsteroidal anti-inflammatory drugs in colorectal cancer: from prevention to therapy.

  British journal of cancer 20030324

• Encapsulation of sodium nimesulide and precursors in beta-cyclodextrin.

  Organic & biomolecular chemistry 20030307

• Simultaneous determination of nimesulide and hydroxynimesulide in rat plasma, cerebrospinal fluid and brain by liquid chromatography using solid-phase extraction.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030305

• Prediction of skin penetration using artificial neural network (ANN) modeling.

  Journal of pharmaceutical sciences 20030301

• A 2 1/2-year-old girl with reflex sympathetic dystrophy syndrome (CRPS type I): case report.

  Clinical rehabilitation 20030301

• Processing of nimesulide-PEG 400-PG-PVP solid dispersions: preparation, characterization, and in vitro dissolution.

  Drug development and industrial pharmacy 20030301

• Physicochemical characterization and dissolution properties of nimesulide-cyclodextrin binary systems.

  AAPS PharmSciTech 20030301

• Role of nitric oxide and cyclooxygenase-2 in regulating the renal hemodynamic response to norepinephrine.

  American journal of physiology. Regulatory, integrative and comparative physiology 20030201

• Hippocampal kindling epileptogenesis upregulates neuronal cyclooxygenase-2 expression in neocortex.

  Experimental neurology 20030201

• Nimesulide vs. paracetamol: this trial needs to stand trial.

  Indian pediatrics 20030201

• In vitro release studies on topical gel formulations of nimesulide.

  Die Pharmazie 20030201

• Differential salutary effects of nonselective and selective COX-2 inhibitors in postoperative ileus in rats.

  The Journal of surgical research 20030201

• Acidic nonsteroidal anti-inflammatory drugs inhibit rat brain fatty acid amide hydrolase in a pH-dependent manner.

  Journal of enzyme inhibition and medicinal chemistry 20030201

• Chemoprevention of Helicobacter pylori-associated gastric carcinogenesis in a mouse model: is it possible?

  Journal of biochemistry and molecular biology 20030131

• Drug linked to child deaths is still available in India.

  BMJ (Clinical research ed.) 20030111

• Effect of nimesulide on gastric acid secretion in the mouse stomach in vitro.

  Life sciences 20030110

• The influence of various methods of cold storage of skin on the permeation of melatonin and nimesulide.

  Journal of controlled release : official journal of the Controlled Release Society 20030109

• Neuroinflammatory role of prostaglandins during experimental meningitis: evidence suggestive of an in vivo relationship between nitric oxide and prostaglandins.

  The Journal of pharmacology and experimental therapeutics 20030101

• The selective cyclooxygenase-2 inhibitor nimesulide induces apoptosis in pancreatic cancer cells independent of COX-2.

  Pancreas 20030101

• A COX-2 inhibitor, nimesulide, inhibits chemically-induced rat tongue carcinogenesis through suppression of cell proliferation activity and COX-2 and iNOS expression.

  Histology and histopathology 20030101

• Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation.

  Acta pharmacologica Sinica 20030101

• Effects of selective cyclooxygenase-2 inhibition on gingival tissue levels of prostaglandin E2 and prostaglandin F2alpha and clinical parameters of chronic periodontitis.

  Journal of periodontology 20030101

• [Cyclooxygenase 2 selective antirheumatic analgesics].

  Wiener medizinische Wochenschrift (1946) 20030101

• COX-2: Where are we in 2003? - Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory disease.

  Arthritis research & therapy 20030101

• Development of agglomerated directly compressible diluent consisting of brittle and ductile materials.

  Pharmaceutical development and technology 20030101

• Determination of antioxidant activity of some drugs using high-pressure liquid chromatography.

  Arzneimittel-Forschung 20030101

• Effects of nimesulide on kainate-induced in vitro oxidative damage in rat brain homogenates.

  BMC pharmacology 20030101

• Nimesulide: is it only an anti-inflammatory, analgesic drug?

  Clinical and experimental rheumatology 20030101

• [Nimesil treatment of gouty arthritis].

  Terapevticheskii arkhiv 20030101

• Chronic urticaria with multiple NSAID intolerance: is tramadol always a safe alternative analgesic?

  Journal of investigational allergology & clinical immunology 20030101

• Is fever suppression involved in the etiology of autism and neurodevelopmental disorders?

  BMC pediatrics 20030101

• Nimesulide controversy in India--time to learn.

  Drug safety 20030101

• The role of COX-2 inhibitors in pain modulation.

  Drugs 20030101

• Central components of the analgesic/antihyperalgesic effect of nimesulide: studies in animal models of pain and hyperalgesia.

  Drugs 20030101

• High-throughput proteomics and protein biomarker discovery in an experimental model of inflammatory hyperalgesia: effects of nimesulide.

  Drugs 20030101

• Inhibition of PGE2 production by nimesulide compared with diclofenac in the acutely inflamed joint of patients with arthritis.

  Drugs 20030101

• A randomised, double-blind, clinical trial comparing the efficacy of nimesulide, celecoxib and rofecoxib in osteoarthritis of the knee.

  Drugs 20030101

• Effect of nimesulide, rofecoxib and celecoxib on gastric tissue glutathione level in rats with indomethacin-induced gastric ulcerations.

  Polish journal of pharmacology 20030101

• Genotoxicity of nimesulide in murine bone marrow cells.

  In vivo (Athens, Greece) 20030101

• Suppression by nimesulide of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats.

  Clinical & experimental metastasis 20030101

• Nimesulide: how safe is it?

  The National medical journal of India 20030101

• Comparative evaluation of the effectiveness and tolerability of nimesulide versus rofecoxib taken once a day in the treatment of patients with knee osteoarthritis.

  American journal of therapeutics 20030101

• Pharmacokinetics of the commonly used NSAID: nimesulide by oral administration to healthy Mexican volunteers.

  Proceedings of the Western Pharmacology Society 20030101

• Effect of cyclooxygenase and NO synthase inhibitors administered centrally on antinociceptive action of acetaminophen (Part II).

  Polish journal of pharmacology 20030101

• Risk factors of adverse drug reaction caused by nimesulide in Shanghai patients with osteoarthropathy.

  Drugs under experimental and clinical research 20030101

• Nimesulide-induced acute hepatotoxicity.

  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 20030101

• Hydroalcoholic plant extracts with anti-inflammatory activity.

  Roumanian archives of microbiology and immunology 20030101

• Intramuscular Dipyrone versus Oral Ibuprofen or Nimesulide for Reduction of Fever in the Outpatient Setting.

  Clinical drug investigation 20030101

• Nimesulide versus Ibuprofen for Postoperative Tonsillectomy Pain : A Double-Blind, Randomised, Active Comparator-Controlled Clinical Trial.

  Clinical drug investigation 20030101

• Anti - inflammatory and sedative - hypnotic activity of the methanolic extract of the leaves of mentha arvensis.

  Ancient science of life 20030101

• Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors.

  British journal of pharmacology 20021201

• Induction of apoptosis in rheumatoid synovial fibroblasts by celecoxib, but not by other selective cyclooxygenase 2 inhibitors.

  Arthritis and rheumatism 20021201

• Direct cytotoxicity of non-steroidal anti-inflammatory drugs in acidic media: model study on human erythrocytes with DIDS-inhibited anion exchanger.

  Die Pharmazie 20021201

• Idiosyncratic NSAID drug induced oxidative stress.

  Chemico-biological interactions 20021110

• Spectral and crystallographic study of pyridinic analogues of nimesulide: determination of the active form of methanesulfonamides as COX-2 selective inhibitors.

  Journal of medicinal chemistry 20021107

• Selective cyclooxygenase-2 inhibitors show a differential ability to inhibit proliferation and induce apoptosis of colon adenocarcinoma cells.

  FEBS letters 20021106

• The critical role of mitochondrial energetic impairment in the toxicity of nimesulide to hepatocytes.

  The Journal of pharmacology and experimental therapeutics 20021101

• Inhibition of cyclooxygenase 2 by nimesulide improves cognitive outcome more than motor outcome following diffuse traumatic brain injury in rats.

  Experimental brain research 20021101

• Role of cyclooxygenase-2 in the prolonged regulation of renal function.

  Hypertension (Dallas, Tex. : 1979) 20021101

• Hepatotoxicity associated with nimesulide: data from the Spanish Pharmacovigilance System.

  Clinical pharmacology and therapeutics 20021101

• Colocalization of BAX with BID and VDAC-1 in nimesulide-induced apoptosis of human colon adenocarcinoma COLO 205 cells.

  Anti-cancer drugs 20021101

• Nimesulide-induced severe hemolytic anemia and acute liver failure leading to liver transplantation.

  Scandinavian journal of gastroenterology 20021101

• Antipyretic effect of nimesulide and paracetamol in children.

  Indian pediatrics 20021101

• On the interaction of specific prostaglandin H synthase-2 inhibitors with prostaglandin H synthase-1.

  European journal of pharmacology 20021025

• Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia.

  European journal of pharmacology 20021025

• Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs.

  The Journal of biological chemistry 20021011

• Biomimetic reduction of nimesulide with NaBH4 catalyzed by metalloporphyrins.

  Chemical & pharmaceutical bulletin 20021001

• Comparison between repeat bolus intrathecal morphine and an epidurally delivered bupivacaine and fentanyl combination in the management of post-thoracotomy pain with or without cyclooxygenase inhibition.

  Journal of cardiothoracic and vascular anesthesia 20021001

• Efficacy of nimesulide in pain relief after day care surgery.

  Indian pediatrics 20021001

• Evaluation of efficacy of nizer versus nimesulide tablets in otitis media.

  Journal of the Indian Medical Association 20021001

• Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis.

  Carcinogenesis 20020901

• Localized toxic pustuloderma associated with nimesulide therapy confirmed by patch testing.

  The British journal of dermatology 20020901

• Efficacy of nimesulide in pain relief after day care surgery.

  Indian pediatrics 20020901

• Post-marketing surveillance of nimesulide suspension.

  Indian pediatrics 20020901

• Gateways to Clinical Trials.

  Methods and findings in experimental and clinical pharmacology 20020901

• Do selective cyclo-oxygenase inhibitors eliminate the adverse events associated with nonsteroidal anti-inflammatory drug therapy?

  European journal of gastroenterology & hepatology 20020901

• Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein.

  The Journal of biological chemistry 20020830

• Effects of nimesulide on nitric oxide-induced hyperalgesia in humans--a neurophysiological study.

  European journal of pharmacology 20020830

• Concurrent administration of Docetaxel and Stealth liposomal doxorubicin with radiotherapy in non-small cell lung cancer : excellent tolerance using subcutaneous amifostine for cytoprotection.

  British journal of cancer 20020812

• Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer.

  Head & neck 20020801

• Nimesulide and diclofenac inhibit lipopolysaccharide-induced hypothermia and tumour necrosis factor-alpha elevation in rats.

  Fundamental & clinical pharmacology 20020801

• Modulatory role of cyclooxygenase inhibitors in aging- and scopolamine or lipopolysaccharide-induced cognitive dysfunction in mice.

  Behavioural brain research 20020718

• Cyclooxygenase inhibitors attenuate endothelin ET(B) receptor-mediated contraction in human temporal artery.

  European journal of pharmacology 20020712

• Chromatographic determination of the association constants between nimesulide and native and modified beta-cyclodextrins.

  Journal of pharmaceutical and biomedical analysis 20020701

• Evaluation of inflammatory parameters in physical urticarias and effects of an anti-inflammatory/antiallergic treatment.

  International journal of dermatology 20020701

• Safety of selective cyclooxygenase-2 inhibitor rofecoxib in patients with NSAID-induced cutaneous reactions.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20020701

• Anti-hyperalgesic effects of nimesulide: studies in rats and humans.

  International journal of clinical practice. Supplement 20020701

• Peripheral analgesic sites of action of anti-inflammatory drugs.

  International journal of clinical practice. Supplement 20020701

• Altered gene expression during nimesulide-mediated inhibition of apoptotic death in human chondrocytes.

  International journal of clinical practice. Supplement 20020701

• Effect of nimesulide on metalloproteinases and matrix degradation in osteoarthritis: a pilot clinical study.

  International journal of clinical practice. Supplement 20020701

• Nimesulide and hepatic adverse effects: roles of reactive metabolites and host factors.

  International journal of clinical practice. Supplement 20020701

• In utero ductal closure following near-term maternal self-medication with nimesulide and acetaminophen.

  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20020701

• Novel coupling reagents for the sensitive spectrophotometric determination of nimesulide in pharmaceutical preparations.

  Journal of pharmaceutical and biomedical analysis 20020620

• Effect of nimesulide on proliferation and apoptosis of human hepatoma SMMC-7721 cells.

  World journal of gastroenterology 20020615

• A randomized controlled trial to evaluate the slow-acting symptom-modifying effects of colchicine in osteoarthritis of the knee: a preliminary report.

  Arthritis and rheumatism 20020615

• Modelling partitioning of sparingly soluble drugs in a two-phase liquid system.

  International journal of pharmaceutics 20020604

• The influence of pellet shape and surface properties on the drug release from uncoated and coated pellets.

  International journal of pharmaceutics 20020604

• Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity.

  Journal of neurophysiology 20020601

• Angiotensin II angiogenic effect in vivo involves vascular endothelial growth factor- and inflammation-related pathways.

  Laboratory investigation; a journal of technical methods and pathology 20020601

• Do NSAIDs affect the progression of osteoarthritis?

  Inflammation 20020601

• Effect of cyclooxygenase inhibitors in postoperative ileus: an experimental study.

  Methods and findings in experimental and clinical pharmacology 20020601

• Investigations of new lead structures for the design of novel cyclooxygenase-2 inhibitors.

  European journal of medicinal chemistry 20020601

• Differential effects of cyclooxygenase inhibitors on haloperidol-induced catalepsy.

  Progress in neuro-psychopharmacology & biological psychiatry 20020601

• [Influence of selective cyclooxygenase-2 inhibitor on proliferation of human gastric cancer cells].

  Ai zheng = Aizheng = Chinese journal of cancer 20020601

• Effects of nimesulide and pentoxifylline on decreased contractile responses in rat ileum with peritonitis.

  European journal of pharmacology 20020503

• Modulation of NSAID-induced antinociceptive and anti-inflammatory effects by alpha2-adrenoceptor agonists with gastroprotective effects.

  Life sciences 20020503

• Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity.

  The Journal of pharmacology and experimental therapeutics 20020501

• Benzydamine: an alternative nonsteroidal anti-inflammatory drug in patients with nimesulide-induced urticaria.

  Allergy 20020501

• The role of spinal neuropeptides and prostaglandins in opioid physical dependence.

  British journal of pharmacology 20020501

• Protective role of cyclooxygenase (COX) inhibitors in burn-induced intestinal and liver damage.

  Burns : journal of the International Society for Burn Injuries 20020501

• COX-2 inhibitor (nimesulide) induced acute liver failure.

  Virchows Archiv : an international journal of pathology 20020501

• Comparison of antipyretic effect of nimesulide and paracetamol in children attending a secondary level hospital.

  Indian pediatrics 20020501

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Randomized pilot study of nimesulide treatment in Alzheimer's disease.

  Neurology 20020409

• The MDR phenotype is associated with the expression of COX-2 and iNOS in a human hepatocellular carcinoma cell line.

  Hepatology (Baltimore, Md.) 20020401

• Metabolism of human articular chondrocytes cultured in alginate beads. Longterm effects of interleukin 1beta and nonsteroidal antiinflammatory drugs.

  The Journal of rheumatology 20020401

• Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes.

  Inflammation 20020401

• Non-steroidal anti-inflammatory drugs inhibit epinephrine- and cAMP-mediated lipolysis in isolated rat adipocytes.

  The Journal of pharmacy and pharmacology 20020401

• A randomized, double-blind, multicenter trial of nimesulide-beta-cyclodextrin versus naproxen in patients with osteoarthritis.

  Clinical therapeutics 20020401

• [Subfulminant hepatitis associated with nimesulide treatment requiring liver transplantation].

  Gastroenterologie clinique et biologique 20020401

• A countrywide post-marketing surveillance of nimesulide suspension.

  Indian pediatrics 20020301

• Comparison of the transdermal absorption of nimesulide from three commercially available gel formulations.

  Drug development and industrial pharmacy 20020301

• Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2.

  Acta neuropathologica 20020201

• Nimesulide and acute renal failure caused by oxalate precipitation.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20020201

• N-(3-Phenoxy-4-pyridinio)methanesulfonamidate.

  Acta crystallographica. Section C, Crystal structure communications 20020201

• Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism.

  Arthritis and rheumatism 20020201

• The effect of nimesulide on the indomethacin- and ethanol-induced gastric ulcer in rats.

  Pharmacological research 20020201

• Efficacy of nimesulide in pain relief after day care surgery.

  Indian pediatrics 20020201

• Increased expression of cyclooxygenase-2 protein during rat hepatocarcinogenesis caused by a choline-deficient, L-amino acid-defined diet and chemopreventive efficacy of a specific inhibitor, nimesulide.

  Carcinogenesis 20020201

• Evaluation of isolated case reports on hepatotoxicity.

  European journal of clinical pharmacology 20020201

• Regulation of prostaglandin production in an immortalized human myometrial cell line by cytokines and non-steroidal anti-inflammatory drugs.

  European journal of obstetrics, gynecology, and reproductive biology 20020110

• Possible ranitidine-induced cholestatic jaundice.

  The Annals of pharmacotherapy 20020101

• Antipyretics in children.

  Indian journal of pediatrics 20020101

• Health needs, drug registration and control in less developed countries--the Peruvian case.

  Pharmacoepidemiology and drug safety 20020101

• Fast analgesic activity from recrystallized nimesulide and its solid dispersion.

  Indian journal of physiology and pharmacology 20020101

• [Nimesulide-induced hepatotoxicity].

  Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 20020101

• COX-2 and prostanoid receptors: good targets for chemoprevention.

  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20020101

• Double-blind, placebo-controlled study of the efficacy and tolerability of nimesulide administered orally in acute bronchial asthma.

  American journal of therapeutics 20020101

• Mechanisms of NSAID-induced hepatotoxicity: focus on nimesulide.

  Drug safety 20020101

• [Nimesil effectiveness in rheumatoid arthritis].

  Klinicheskaia meditsina 20020101

• Efficacy and specificity of non-steroidal anti-inflammatory drugs for the inhibition of cytokine-stimulated prostaglandin E(2) secretion by amnion-derived WISH cells.

  Prostaglandins, leukotrienes, and essential fatty acids 20020101

• [Nimesulide (Aulin)--the selective COX-2 inhibitor in the treatment of ENT diseases].

  Otolaryngologia polska = The Polish otolaryngology 20020101

• Nimesulide and melatonin in mammary carcinogenesis prevention in female Sprague-Dawley rats.

  Neoplasma 20020101

• Changes in size of periarthritis calcifications in patients with painful shoulder treated with injectable disodium-clodronate.

  International journal of clinical pharmacology research 20020101

• Effect of nimesulide on the indomethacin- and ibuprofen-induced ulcer in rat gastric tissue.

  Polish journal of pharmacology 20020101

• Extensive fixed drug eruption to nimesulide with cross-sensitivity to sulfonamides in a child.

  Pediatric dermatology 20020101

• Studies in topical application of niosomally entrapped Nimesulide.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20020101

• [Use of nonsteroidal anti-inflammatory drugs in patients with vertebral osteoporotic fractures].

  Reumatismo 20020101

• Chemopreventive effects of nimesulide, a selective cyclooxygenase-2 inhibitor, against PhIP-induced mammary carcinogenesis.

  Advances in experimental medicine and biology 20020101

• A novel embedment-free immunoelectron microscopy technique reveals association of apoptosis-regulating proteins with subcellular structures.

  The Histochemical journal 20020101

• Hypoglycaemia and hypothermia due to nimesulide overdose.

  Archives of disease in childhood 20011201

• Quantification of nimesulide in human plasma by high-performance liquid chromatography/tandem mass spectrometry. Application to bioequivalence studies.

  Journal of mass spectrometry : JMS 20011201

• The effect of alpha-melanocyte stimulating hormone on endotoxin-induced intestinal injury.

  Peptides 20011201

• Cyclo-oxygenase-1/cyclo-oxygenase-2 non selective non-steroidal anti-inflammatory drugs: epidemiology of gastrointestinal events.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20011201

• Lichenoid photodermatitis associated with nimesulide.

  International journal of dermatology 20011201

• Identification of dual cyclooxygenase-eicosanoid oxidoreductase inhibitors: NSAIDs that inhibit PG-LX reductase/LTB(4) dehydrogenase.

  Biochemical and biophysical research communications 20011109

• Effects of nimesulide and its metabolites or manufacturing intermediates on the viability and growth of the human hepatoma HepG2 cell line.

  Life sciences 20011109

• Role of COX-2-derived metabolites in regulation of the renal hemodynamic response to norepinephrine.

  American journal of physiology. Renal physiology 20011101

• Activation of cyclo-oxygenase-2 contributes to motor and cognitive dysfunction following diffuse traumatic brain injury in rats.

  Clinical and experimental pharmacology & physiology 20011101

• Fenamates stimulate BKCa channel osteoblast-like MG-63 cells activity in the human.

  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20011101

• Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.

  Immunopharmacology and immunotoxicology 20011101

• COX-2 inhibitors compared and contrasted.

  Expert opinion on pharmacotherapy 20011101

• CaR-mediated COX-2 expression in primary cultured mTAL cells.

  American journal of physiology. Renal physiology 20011001

• Uterine relaxant effects of cyclooxygenase-2 inhibitors in vitro.

  Obstetrics and gynecology 20011001

• Evaluation of skin sensitization potential of melatonin and nimesulide by murine local lymph node assay.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20011001

• The effects of cervical application of inhibitors of inducible nitric oxide synthase, cyclooxygenase-1, and cyclooxygenase-2 on delivery in rats.

  American journal of obstetrics and gynecology 20011001

• Pathogenetic role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome: therapeutic use of the cyclooxygenase-2 inhibitor nimesulide.

  Clinical pharmacology and therapeutics 20011001

• Double-blind study comparing the long-term efficacy of the COX-2 inhibitor nimesulide and naproxen in patients with osteoarthritis.

  International journal of clinical practice 20011001

• Nicotine-induced contraction in the rat coronary artery: possible involvement of the endothelium, reactive oxygen species and COX-1 metabolites.

  Journal of cardiovascular pharmacology 20011001

• Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut.

  Inflammation 20011001

• Lipopolysaccharide-mediated immobility in mice: reversal by cyclooxygenase enzyme inhibitors.

  Methods and findings in experimental and clinical pharmacology 20011001

• Tolerability to new COX-2 inhibitors in NSAID-sensitive patients with cutaneous reactions.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010901

• Nimesulide-induced acute hepatitis.

  The Annals of pharmacotherapy 20010901

• Cyclooxygenase selectivity of non-steroid anti-inflammatory drugs in humans: ex vivo evaluation.

  European journal of pharmacology 20010824

• Cyclooxygenase-2 mediates the febrile response of mice to interleukin-1beta.

  Brain research 20010810

• Prevention of postoperative adhesion formation in rat uterine horn model by nimesulide: a selective COX-2 inhibitor.

  Human reproduction (Oxford, England) 20010801

• Subcellular redistribution of BAX during apoptosis induced by anticancer drugs.

  Anti-cancer drugs 20010801

• Effects of furocoumarins from Cachrys trifida on some macrophage functions.

  The Journal of pharmacy and pharmacology 20010801

• Tolerability of nimesulide and paracetamol in patients with NSAID-induced urticaria/angioedema.

  Immunopharmacology and immunotoxicology 20010801

• Corneal stimulation of MMP-1, -9 and uPA by platelet-activating factor is mediated by cyclooxygenase-2 metabolites.

  Current eye research 20010801

• Evaluation of efficacy and safety of nimesulide with betacyclodextrin vs nimesulide tablets in osteoarthritis.

  Journal of the Indian Medical Association 20010801

• Rapid and simple high-performance liquid chromatographic determination of nimesulide in human plasma.

  Journal of chromatography. B, Biomedical sciences and applications 20010715

• Drug Points: Cholestatic hepatitis in association with celecoxib.

  BMJ (Clinical research ed.) 20010707

• Hypothermia with nimesulide.

  Indian pediatrics 20010701

• Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria.

  Planta medica 20010701

• Fatal hepatoxicity secondary to nimesulide.

  European journal of clinical pharmacology 20010701

• Role of cysteinyl leukotrienes in nociceptive and inflammatory conditions in experimental animals.

  European journal of pharmacology 20010629

• The uncoupling effect of the nonsteroidal anti-inflammatory drug nimesulide in liver mitochondria from adjuvant-induced arthritic rats.

  Cell biochemistry and function 20010601

• HPTLC determination of nimesulide from pharmaceutical dosage forms.

  Journal of pharmaceutical and biomedical analysis 20010601

• Inhibition of cervical ripening by local application of cyclooxygenase 2 inhibitor.

  American journal of obstetrics and gynecology 20010601

• [Neonatal chronic kidney failure associated with cyclo-oxygenase-2 inhibitors administered during pregnancy].

  Minerva urologica e nefrologica = The Italian journal of urology and nephrology 20010601

• Kupffer cell-derived cyclooxygenase-2 regulates hepatocyte Bcl-2 expression in choledocho-venous fistula rats.

  American journal of physiology. Gastrointestinal and liver physiology 20010501

• Differing mechanisms of inhibition of calcium increases in human uterine myocytes by indomethacin and nimesulide.

  American journal of obstetrics and gynecology 20010501

• Pustular psoriasis of the nails: treatment and long-term follow-up of 46 patients.

  The British journal of dermatology 20010501

• Efficacy of nimesulide alone and in combination with cetirizine in acute allergic rhinitis.

  The Journal of the Association of Physicians of India 20010501

• Nimesulide aggravates kainic acid-induced seizures in the rat.

  Pharmacology & toxicology 20010501

• Nimesulide reduces interleukin-1beta-induced cyclooxygenase-2 gene expression in human synovial fibroblasts.

  Osteoarthritis and cartilage 20010501

• Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve.

  British journal of pharmacology 20010401

• [Nimesulide-induced acute hepatitis].

  Gastroenterologia y hepatologia 20010401

• Drug-induced cholestasis.

  Seminars in gastrointestinal disease 20010401

• The basis of prostaglandin synthesis in coral: molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosa.

  The Journal of biological chemistry 20010309

• Selective inhibition of COX-2 in humans is associated with less gastrointestinal injury: a comparison of nimesulide and naproxen.

  Gut 20010301

• Can a cyclo-oxygenase type-2 selective tocolytic agent avoid the fetal side effects of indomethacin?

  BJOG : an international journal of obstetrics and gynaecology 20010301

• A reduction of tumor necrosis factor-alpha in paw exudate of lipopolysaccharide treated rats by nimesulide.

  Life sciences 20010223

• Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor, nimesulide.

  Cancer research 20010215

• Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2.

  The Journal of pharmacology and experimental therapeutics 20010201

• Resistance to melanoma metastases in mice selected for high acute inflammatory response.

  Carcinogenesis 20010201

• Long-term glucose infusion increases arterial pressure in dogs with cyclooxygenase-2 inhibition.

  Hypertension (Dallas, Tex. : 1979) 20010201

• Inhibitory effect of serine protease inhibitors on neutrophil-mediated endothelial cell injury.

  Journal of leukocyte biology 20010201

• Pharmacokinetic profile and in vitro selective cyclooxygenase-2 inhibition by nimesulide in the dog.

  Journal of veterinary pharmacology and therapeutics 20010201

• A pharmacokinetic/pharmacodynamic approach vs. a dose titration for the determination of a dosage regimen: the case of nimesulide, a Cox-2 selective nonsteroidal anti-inflammatory drug in the dog.

  Journal of veterinary pharmacology and therapeutics 20010201

• Protective role of cyclooxygenase inhibitors in the adverse action of passive cigarette smoking on the initiation of experimental colitis in rats.

  European journal of pharmacology 20010105

• Intrarenal expression and distribution of cyclooxygenase isoforms in rats with experimental heart failure.

  American journal of physiology. Renal physiology 20010101

• Role of PGE(2) in protease-activated receptor-1, -2 and -4 mediated relaxation in the mouse isolated trachea.

  British journal of pharmacology 20010101

• Introduction to 'nimesulide: beyond COX-2'.

  Clinical and experimental rheumatology 20010101

• Inhibition of gastric acid secretion by nimesulide: a possible factor in its gastric tolerability.

  Clinical and experimental rheumatology 20010101

• The role of NSAIDs in psoriatic arthritis: evidence from a controlled study with nimesulide.

  Clinical and experimental rheumatology 20010101

• Nimesulide, a balanced drug for the treatment of osteoarthritis.

  Clinical and experimental rheumatology 20010101

• Differential regulation of interleukin-1 beta-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts.

  Clinical and experimental rheumatology 20010101

• Non-steroidal anti-inflammatory drugs protect against chondrocyte apoptotic death.

  Clinical and experimental rheumatology 20010101

• [Selective cyclooxygenase 2 inhibitors (COX-2)].

  Postepy higieny i medycyny doswiadczalnej 20010101

• [Lithium poisoning and the use of nimesulide].

  Recenti progressi in medicina 20010101

• The ever-emerging anti-inflammatories. Have there been any real advances?

  Journal of physiology, Paris 20010101

• Inhibition of prostaglandin synthesis and its effect on uterine activity during established premature labor in sheep.

  Journal of the Society for Gynecologic Investigation 20010101

• Adverse drug reactions related to the use of NSAIDs with a focus on nimesulide: results of spontaneous reporting from a Northern Italian area.

  Drug safety 20010101

• Risks and benefits of nonsteroidal anti-inflammatory drugs in children: a comparison with paracetamol.

  Paediatric drugs 20010101

• Patient and physician satisfaction with rofecoxib in osteoarthritis: results of the EVA (experience with VIOXX in arthritis) survey.

  Current medical research and opinion 20010101

• NSAID antinociception measured in a chemical and a thermal assay in mice.

  Pain research & management 20010101

• Evaluation of a selective prostaglandin E receptor EP1 antagonist for potential properties in colon carcinogenesis.

  Anticancer research 20010101

• Differential inhibition by nimesulide of the early and late phases of intravenous- and intracerebroventricular-LPS-induced fever in guinea pigs.

  Neuroimmunomodulation 20010101

• Effect of cyclooxygenase and NO synthase inhibitors on antinociceptive action of acetaminophen.

  Polish journal of pharmacology 20010101

• [Toxic hepatitis caused by nimesulide, presentation of a new case and review of the literature].

  Gastroenterologia y hepatologia 20001101

• Involvement of cyclooxygenase 2 in the protective effect of 17beta-estradiol on hypercholesterolemic rabbit aorta.

  Biochemical and biophysical research communications 20000828

• Leukotriene receptor antagonists may prevent NSAID-induced exacerbations in patients with chronic urticaria.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20000801

• Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells.

  Gastroenterology 20000601

• The COX-2 inhibitor nimesulide suppresses superoxide and 8-hydroxy-deoxyguanosine formation, and stimulates apoptosis in mucosa during early colonic inflammation in rats.

  Carcinogenesis 20000501

• The use of nimesulide in patients with acetylsalicylic acid and nonsteroidal anti-inflammatory drug intolerance.

  The Journal of asthma : official journal of the Association for the Care of Asthma 19991201

• Nimesulide-induced hepatitis and acute liver failure.

  The Israel Medical Association journal : IMAJ 19991001

• Risk factors for acetaminophen and nimesulide intolerance in patients with NSAID-induced skin disorders.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 19990601

• Acute cholestatic hepatitis induced by nimesulide.

  Liver 19990401

• Nimesulide-induced acute hepatitis: evidence from six cases.

  Journal of hepatology 19980701

• Portal venous transfusion up-regulates Kupffer cell cyclooxygenase activity: a mechanism of immunosuppression in organ transplantation.

  Transplantation 19970715

• Long-term tolerability of nimesulide and acetaminophen in nonsteroidal antiinflammatory drug-intolerant patients.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 19970701

• Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity.

  Journal of medicinal chemistry 19970314

• Interaction between enoxacin, a new antimicrobial, and nimesulide, a new non-steroidal anti-inflammatory agent in mice.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 19960801