51866-19-4 | 6-Ethoxy-9h-purin-2-amine

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$97.00	$68.00
5g	95%	in stock	$330.00	$231.00
25g	95%	in stock	$1,240.00	$868.00

Description

• Catalog Number: AG23750
• Chemical Name: 6-Ethoxy-9h-purin-2-amine
• CAS Number: 51866-19-4
• Molecular Formula: C7H9N5O
• Molecular Weight: 179.17925999999997
• MDL Number: MFCD20482033
• SMILES: CCOc1nc(N)nc2c1nc[nH]2
• NSC Number: 37368

Computed Properties

• Complexity: 178
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: 0.1

Literature

• DNA damage and reactive nitrogen species are barriers to Vibrio cholerae colonization of the infant mouse intestine.

  PLoS pathogens 20110201

• Binding of MutS protein to oligonucleotides containing a methylated or an ethylated guanine residue, and correlation with mutation frequency.

  Mutation research 20080402

• Niacin deficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow.

  Mutation research 20071201

• Differences in the rate of repair of O6-alkylguanines in different sequence contexts by O6-alkylguanine-DNA alkyltransferase.

  Chemical research in toxicology 20071201

• Polymorphisms of phase II xenobiotic-metabolizing and DNA repair genes and in vitro N-ethyl-N-nitrosourea-induced O6-ethylguanine levels in human lymphocytes.

  Mutation research 20070305

• Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives.

  Journal of medicinal chemistry 20020801

• Mutagenesis by O(6)-methyl-, O(6)-ethyl-, and O(6)-benzylguanine and O(4)-methylthymine in human cells: effects of O(6)-alkylguanine-DNA alkyltransferase and mismatch repair.

  Chemical research in toxicology 20010701

• In vivo repair of ENU-induced oxygen alkylation damage by the nucleotide excision repair mechanism in Drosophila melanogaster.

  Molecular genetics and genomics : MGG 20010401

• DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance.

  Mutation research 20000401

• Marked differences in the role of O6-alkylguanine in hprt mutagenesis in T-lymphocytes of rats exposed in vivo to ethylmethanesulfonate, N-(2-hydroxyethyl)-N-nitrosourea, or N-ethyl-N-nitrosourea.

  Cancer research 19950501