528-48-3 | 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one

Packsize	Purity	Availability	Price	Discounted Price
100mg	>96.0%(HPLC)	in stock	$35.00	$24.00
500mg	≥90%	in stock	$101.00	$71.00
1g	>97%(HPLC)powder	in stock	$103.00	$73.00

Description

• Catalog Number: AG24754
• Chemical Name: 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one
• CAS Number: 528-48-3
• Molecular Formula: C15H10O6
• Molecular Weight: 286.2363
• MDL Number: MFCD00006829
• SMILES: Oc1ccc2c(c1)oc(c(c2=O)O)c1ccc(c(c1)O)O

Computed Properties

• Complexity: 459
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 1
• XLogP3: 2

Literature

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  International journal of oncology 20111001

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• Photophysical behavior of fisetin in dimyristoylphosphatidylcholine liposome membrane.

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• Rapid effects of phytoestrogens on human colonic smooth muscle are mediated by oestrogen receptor beta.

  Molecular and cellular endocrinology 20100514

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  The Analyst 20100501

• Lactacidosis modulates glutathione metabolism and oxidative glutamate toxicity.

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• On-line HPLC method for screening of antioxidants against superoxide anion radical from complex mixtures.

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• Apoptosis by dietary agents for prevention and treatment of prostate cancer.

  Endocrine-related cancer 20100301

• The actions of fisetin on glucose metabolism in the rat liver.

  Cell biochemistry and function 20100301

• An in vitro micronucleus assay with size-classified micronucleus counting to discriminate aneugens from clastogens.

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• Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.

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• Antimetastatic potential of fisetin involves inactivation of the PI3K/Akt and JNK signaling pathways with downregulation of MMP-2/9 expressions in prostate cancer PC-3 cells.

  Molecular and cellular biochemistry 20100101

• Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase.

  European journal of medicinal chemistry 20100101

• Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.

  Bioorganic & medicinal chemistry 20100101

• Protection of burn-induced skin injuries by the flavonoid kaempferol.

  BMB reports 20100101

• The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies.

  International journal of cell biology 20100101

• Excess production of Bacillus subtilis quercetin 2,3-dioxygenase affects cell viability in the presence of quercetin.

  Bioscience, biotechnology, and biochemistry 20100101

• Modulation of multidrug resistance p-glycoprotein activity by flavonoids and honokiol in human doxorubicin- resistant sarcoma cells (MES-SA/DX-5): implications for natural sedatives as chemosensitizing agents in cancer therapy.

  Journal of biological regulators and homeostatic agents 20100101

• Fisetin induces apoptosis in Huh-7 cells via downregulation of BIRC8 and Bcl2L2.

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• Apoptotic effects of chrysin in human cancer cell lines.

  International journal of molecular sciences 20100101

• Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells.

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• Electrochemical and density functional theory study on the reactivity of fisetin and its radicals: implications on in vitro antioxidant activity.

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• Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin.

  Genes & nutrition 20091201

• Comparison of extraction methods for the analysis of natural dyes in historical textiles by high-performance liquid chromatography.

  Analytical and bioanalytical chemistry 20091201

• Swiprosin-1 Regulates Cytokine Expression of Human Mast Cell Line HMC-1 through Actin Remodeling.

  Immune network 20091201

• Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB.

  International journal of cancer 20091115

• Involvement of the ERK signaling pathway in fisetin reduces invasion and migration in the human lung cancer cell line A549.

  Journal of agricultural and food chemistry 20091014

• Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha.

  The Journal of biological chemistry 20091002

• The hydroxyflavone, fisetin, suppresses mast cell activation induced by interaction with activated T cell membranes.

  British journal of pharmacology 20091001

• Structure and antioxidant activity of brominated flavonols and flavanones.

  Journal of mass spectrometry : JMS 20091001

• Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay.

  Bioorganic & medicinal chemistry letters 20090815

• Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy.

  Current genomics 20090801

• Potential neuroprotective drugs in cerebral ischemia: new saturated and polyunsaturated lipids coupled to hydrophilic moieties: synthesis and biological activity.

  Journal of medicinal chemistry 20090723

• Phytochemical analysis of young fustic (Cotinus coggygria heartwood) and identification of isolated colourants in historical textiles.

  Analytical and bioanalytical chemistry 20090601

• Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint.

  Carcinogenesis 20090601

• Inhibitory effects of flavonoids on TNF-alpha-induced IL-8 gene expression in HEK 293 cells.

  BMB reports 20090531

• Inhibition of LPS-induced pulmonary inflammation by specific flavonoids.

  Biochemical and biophysical research communications 20090508

• Study on fisetin-aluminium(III) interaction in aqueous buffered solutions by spectroscopy and molecular modeling.

  Journal of inorganic biochemistry 20090501

• Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin.

  American journal of physiology. Gastrointestinal and liver physiology 20090501

• Distribution and major sources of flavonoid intakes in the middle-aged Japanese women.

  Journal of clinical biochemistry and nutrition 20090501

• In vitro antiproliferative characteristics of flavonoids and diazepam on SNU-C4 colorectal adenocarcinoma cells.

  Journal of natural medicines 20090401

• Comparison of intraperitoneal honey and sodium hyaluronate-carboxymethylcellulose (Seprafilm) for the prevention of postoperative intra-abdominal adhesions.

  Clinics (Sao Paulo, Brazil) 20090401

• Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

  Molecular and cellular endocrinology 20090325

• Mechanism of CYP2C9 inhibition by flavones and flavonols.

  Drug metabolism and disposition: the biological fate of chemicals 20090301

• Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models.

  International immunopharmacology 20090301

• Development of an in vitro test system measuring transcriptional downregulatory activities on IL-13.

  Journal of microbiology and biotechnology 20090301

• MS/MS spectral tag-based annotation of non-targeted profile of plant secondary metabolites.

  The Plant journal : for cell and molecular biology 20090201

• A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways.

  Carcinogenesis 20090201

• Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites.

  Journal of agricultural and food chemistry 20090114

• Flavonoid-induced morphological modifications of endothelial cells through microtubule stabilization.

  Nutrition and cancer 20090101

• Synergetic effects of granulocyte-colony stimulating factor and cognitive training on spatial learning and survival of newborn hippocampal neurons.

  PloS one 20090101

• Selective cytotoxic effects on human cancer cell lines of phenolic-rich ethyl-acetate fraction from Rhus verniciflua Stokes.

  The American journal of Chinese medicine 20090101

• Yeast artificial chromosomes employed for random assembly of biosynthetic pathways and production of diverse compounds in Saccharomyces cerevisiae.

  Microbial cell factories 20090101

• Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells.

  Journal of biomedicine & biotechnology 20090101

• Directed therapy for exfoliation syndrome.

  The open ophthalmology journal 20090101

• Directed Therapy: An Approach to the Improved Treatment of Exfoliation syndrome.

  Middle East African journal of ophthalmology 20090101

• MLL leukemia-associated rearrangements in peripheral blood lymphocytes from healthy individuals.

  Genetics and molecular biology 20090101

• Analysis of flavonoids in propolis and Ginkgo biloba by micellar electrokinetic capillary chromatography.

  Journal of agricultural and food chemistry 20081224

• Ultrasound extracted flavonoids from four varieties of Portuguese red grape skins determined by reverse-phase high-performance liquid chromatography with electrochemical detection.

  Analytica chimica acta 20081223

• Establishment of a transgenic yeast screening system for estrogenicity and identification of the anti-estrogenic activity of malachite green.

  Journal of cellular biochemistry 20081215

• Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis.

  British journal of cancer 20081209

• Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid beta protein.

  Neuroscience letters 20081031

• A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice.

  Cancer research 20081015

• Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages.

  Biochimica et biophysica acta 20081001

• Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells.

  Archives of pharmacal research 20081001

• Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells.

  Carcinogenesis 20080901

• Protective effects of epigallocatechin gallate after UV irradiation of cultured human lens epithelial cells.

  Korean journal of ophthalmology : KJO 20080901

• The flavonoid fisetin promotes nerve cell survival from trophic factor withdrawal by enhancement of proteasome activity.

  Archives of biochemistry and biophysics 20080815

• Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells.

  Cancer letters 20080708

• Dietary agents for chemoprevention of prostate cancer.

  Cancer letters 20080708

• Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells.

  Biological & pharmaceutical bulletin 20080701

• Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells.

  Carcinogenesis 20080501

• Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity.

  International immunopharmacology 20080301

• The effect of flavonoid derivatives on doxorubicin transport and metabolism.

  Bioorganic & medicinal chemistry 20080215

• Flavonoids induce HIF-1alpha but impair its nuclear accumulation and activity.

  Free radical biology & medicine 20080215

• Comparative anticancer effects of flavonoids and diazepam in cultured cancer cells.

  Biological & pharmaceutical bulletin 20080201

• Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons.

  Brain research 20080116

• Potentiometric determination of aqueous dissociation constants of flavonols sparingly soluble in water.

  Talanta 20080115

• Flavonoids with DNA strand-scission activity from Rhus javanica var. roxburghiana.

  Fitoterapia 20080101

• [Spectroscopic characterization of binding between human serum albumin and 3,3', 4',7-tetrahydroxyflavone].

  Guang pu xue yu guang pu fen xi = Guang pu 20080101

• The flavonoid, fisetin, inhibits UV radiation-induced oxidative stress and the activation of NF-kappaB and MAPK signaling in human lens epithelial cells.

  Molecular vision 20080101

• Inflammaging as a prodrome to Alzheimer's disease.

  Journal of neuroinflammation 20080101

• Cupric ion reducing antioxidant capacity assay for food antioxidants: vitamins, polyphenolics, and flavonoids in food extracts.

  Methods in molecular biology (Clifton, N.J.) 20080101

• Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans.

  PloS one 20080101

• Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans.

  Archives of toxicology 20071201

• Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.

  Bioorganic & medicinal chemistry 20071201

• Protective effects of epigallocatechin gallate after UV irradiation in cultured human retinal pigment epithelial cells.

  Korean journal of ophthalmology : KJO 20071201

• [Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60].

  Ai zheng = Aizheng = Chinese journal of cancer 20071201

• A novel approach to screening for new neuroprotective compounds for the treatment of stroke.

  Brain research 20071010

• Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071001

• Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase.

  Bioorganic & medicinal chemistry 20071001

• Determination of flavonoid aglycones in several food samples by mixed micellar electrokinetic chromatography.

  Journal of separation science 20071001

• Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells.

  The Journal of nutrition 20071001

• Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II.

  Microbiology (Reading, England) 20071001

• Phosphoprotein levels, MAPK activities and NFkappaB expression are affected by fisetin.

  Journal of enzyme inhibition and medicinal chemistry 20070801

• Inhibitory effects of diesel exhaust components and flavonoids on 20alpha-hydroxysteroid dehydrogenase activity in mouse tissues.

  Journal of enzyme inhibition and medicinal chemistry 20070801

• Structure-activity relationship of flavonoids for inhibition of epidermal growth factor-induced transformation of JB6 Cl 41 cells.

  Molecular carcinogenesis 20070601

• Interaction of flavonoids with red blood cell membrane lipids and proteins: antioxidant and antihemolytic effects.

  International journal of biological macromolecules 20070601

• Flavonoids and related compounds as anti-allergic substances.

  Allergology international : official journal of the Japanese Society of Allergology 20070601

• Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation.

  Molecular pharmacology 20070601

• Interaction of flavonoids and intestinal facilitated glucose transporters.

  Planta medica 20070401

• 3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.

  Bioorganic & medicinal chemistry letters 20070301

• The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation.

  Diabetes 20070301

• Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo.

  Drug metabolism and disposition: the biological fate of chemicals 20070201

• Design and synthesis of compounds that extend yeast replicative lifespan.

  Aging cell 20070201

• Inhibition of the intestinal glucose transporter GLUT2 by flavonoids.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070201

• Anti-inflammatory activity of fisetin in human mast cells (HMC-1).

  Pharmacological research 20070101

• Comparative study of the photophysical behavior of fisetin in homogeneous media and in anionic and cationic reverse micelles media.

  Photochemistry and photobiology 20070101

• Distinctive antioxidant and antiinflammatory effects of flavonols.

  Journal of agricultural and food chemistry 20061227

• Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

  Journal of molecular graphics & modelling 20061101

• A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives.

  Free radical research 20061001

• Zinc neurotoxicity is dependent on intracellular NAD levels and the sirtuin pathway.

  The European journal of neuroscience 20061001

• Study of the complexation of fisetin with cyclodextrins.

  The journal of physical chemistry. A 20060914

• Nutraceutical inhibitors of urokinase: potential applications in prostate cancer prevention and treatment.

  Oncology reports 20060801

• Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death.

  Investigative ophthalmology & visual science 20060701

• Anti-platelet effects of bioactive compounds isolated from the bark of Rhus verniciflua Stokes.

  Journal of ethnopharmacology 20060615

• Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.

  Journal of medicinal chemistry 20060601

• Characteristics and inhibition by flavonoids of 20alpha-hydroxysteroid dehydrogenase activity in mouse tissues.

  Life sciences 20060515

• Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.

  Toxicology in vitro : an international journal published in association with BIBRA 20060301

• Antioxidants from Rabdosia japonica.

  Phytotherapy research : PTR 20060301

• Effect of different flavonoids on collagen synthesis in human fibroblasts.

  Plant foods for human nutrition (Dordrecht, Netherlands) 20060301

• Luteolin, a flavonoid, inhibits AP-1 activation by basophils.

  Biochemical and biophysical research communications 20060203

• Improved cold preservation of kidney tubular cells by means of adding bioflavonoids to organ preservation solutions.

  Transplantation 20060127

• Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines.

  Prostate cancer and prostatic diseases 20060101

• A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets.

  Journal of natural products 20060101

• Luteolin, a flavonoid, inhibits CD40 ligand expression by activated human basophils.

  International archives of allergy and immunology 20060101

• Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.

  Journal of medicinal chemistry 20051201

• Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells.

  Biological & pharmaceutical bulletin 20051201

• Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells.

  Biochimica et biophysica acta 20051130

• Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid.

  Journal of agricultural and food chemistry 20051102

• Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro.

  Archives of pharmacal research 20051101

• Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids.

  Molecular pharmacology 20051001

• Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease.

  Free radical research 20051001

• Properties of normal and glycated human hemoglobin in presence and absence of antioxidant.

  Biochemical and biophysical research communications 20050902

• Dietary flavonoids as intracellular substrates for an erythrocyte trans-plasma membrane oxidoreductase activity.

  The British journal of nutrition 20050901

• Interactions of the plant flavonoid fisetin with macromolecular targets: insights from fluorescence spectroscopic studies.

  Journal of photochemistry and photobiology. B, Biology 20050801

• Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice.

  Biochemical pharmacology 20050715

• Inhibition of P-glycoprotein by natural products in human breast cancer cells.

  Archives of pharmacal research 20050701

• Determination of dissociation constants of flavonoids by capillary electrophoresis.

  Electrophoresis 20050501

• Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids.

  Archives of pharmacal research 20050501

• Chromosomal malsegregation and micronucleus induction in vitro by the DNA topoisomerase II inhibitor fisetin.

  Mutation research 20050404

• A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase.

  Nitric oxide : biology and chemistry 20050301

• Synergistic effects of flavonoids and ascorbate on enhancement in DNA degradation induced by a bleomycin-Fe complex.

  Free radical research 20050301

• Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.

  Journal of medicinal chemistry 20050210

• Evaluation of the antioxidant activity of flavonoids by 'ferric reducing antioxidant power' assay and cyclic voltammetry.

  Biochimica et biophysica acta 20050118

• Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method.

  Journal of agricultural and food chemistry 20041229

• Vascular and anti-oxidant actions of flavonols and flavones.

  Clinical and experimental pharmacology & physiology 20041101

• Oxidation products of quercetin catalyzed by mushroom tyrosinase.

  Bioorganic & medicinal chemistry 20041015

• Extract from Rhus verniciflua Stokes is capable of inhibiting the growth of human lymphoma cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040901

• Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation.

  Journal of neurochemistry 20040901

• Sirtuin activators mimic caloric restriction and delay ageing in metazoans.

  Nature 20040805

• Investigations on the binding and antioxidant properties of the plant flavonoid fisetin in model biomembranes.

  FEBS letters 20040716

• Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils.

  International archives of allergy and immunology 20040601

• Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs.

  Drug metabolism and disposition: the biological fate of chemicals 20040601

• Structural requirements of flavonoids for increment of ocular blood flow in the rabbit and retinal function recovery in rat eyes.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040601

• Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferase.

  Drug metabolism and disposition: the biological fate of chemicals 20040501

• Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport.

  Molecular pharmacology 20040501

• Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake.

  The Journal of biological chemistry 20040109

• Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua.

  Journal of ethnopharmacology 20040101

• Flavonoids induce apoptosis in human leukemia U937 cells through caspase- and caspase-calpain-dependent pathways.

  Nutrition and cancer 20040101

• Some aspects of the in vivo neuroprotective capacity of flavonoids: bioavailability and structure-activity relationship.

  Neurotoxicity research 20040101

• Phenolic compounds and flavonoids as plant growth regulators from fruit and leaf of Vitex rotundifolia.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101

• Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta.

  Life sciences 20031219

• Neuroprotection by flavonoids.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20031201

• Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha.

  Phytotherapy research : PTR 20031201

• Stable free radical scavenging and antiperoxidative properties of resveratrol compared in vitro with some other bioflavonoids.

  Indian journal of biochemistry & biophysics 20031201

• Inhibitory effects of plant-derived flavonoids and phenolic acids on malonaldehyde formation from ethyl arachidonate.

  Journal of agricultural and food chemistry 20031119

• Different antioxidant effects of polyphenols on lipid peroxidation and hydroxyl radicals in the NADPH-, Fe-ascorbate- and Fe-microsomal systems.

  Biochemical pharmacology 20031001

• Free radical scavenging abilities of flavonoids as mechanism of protection against mutagenicity induced by tert-butyl hydroperoxide or cumene hydroperoxide in Salmonella typhimurium TA102.

  Mutation research 20030909

• Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants.

  Naunyn-Schmiedeberg's archives of pharmacology 20030901

• Anti-allergic substances contained in the pollen of Cryptomeria japonica possess diverse effects on the degranulation of RBL-2H3 cells.

  Journal of pharmacological sciences 20030701

• Fisetin, a flavonol, inhibits TH2-type cytokine production by activated human basophils.

  The Journal of allergy and clinical immunology 20030601

• HTS compatible assay for antioxidative agents using primary cultured hepatocytes.

  Assay and drug development technologies 20030601

• Differential effects of quercetin, a natural polyphenolic flavonoid, on L-type calcium current in pituitary tumor (GH3) cells and neuronal NG108-15 cells.

  Journal of cellular physiology 20030501

• Inhibitory effects of some flavonoids on the activity of mushroom tyrosinase.

  Biochemistry. Biokhimiia 20030401

• Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy.

  Journal of agricultural and food chemistry 20030312

• Effects of iridoids on lipoxygenase and hyaluronidase activities and their activation by beta-glucosidase in the presence of amino acids.

  Biological & pharmaceutical bulletin 20030301

• Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action.

  Biochemical pharmacology 20030301

• Flavonoids inhibit myelin phagocytosis by macrophages; a structure-activity relationship study.

  Biochemical pharmacology 20030301

• Effect of flavonoids on MRP1-mediated transport in Panc-1 cells.

  Journal of pharmaceutical sciences 20030201

• Bioflavonoids attenuate renal proximal tubular cell injury during cold preservation in Euro-Collins and University of Wisconsin solutions.

  Kidney international 20030201

• Cell culture protection and in vivo neuroprotective capacity of flavonoids.

  Neurotoxicity research 20030101

• Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.

  Journal of natural products 20021201

• Nitric oxide formation and corresponding relaxation of porcine coronary arteries induced by plant phenols: essential structural features.

  Journal of cardiovascular pharmacology 20021101

• Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells.

  Bioorganic & medicinal chemistry 20021001

• Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1.

  Archives of toxicology 20020601

• Methylation of quercetin and fisetin, flavonoids widely distributed in edible vegetables, fruits and wine, by human liver.

  International journal of clinical pharmacology and therapeutics 20020501

• Rutin-enhanced antibacterial activities of flavonoids against Bacillus cereus and Salmonella enteritidis.

  Bioscience, biotechnology, and biochemistry 20020501

• Structure-activity relationships for inhibition of human 5alpha-reductases by polyphenols.

  Biochemical pharmacology 20020315

• The regioselectivity of glutathione adduct formation with flavonoid quinone/quinone methides is pH-dependent.

  Chemical research in toxicology 20020301

• Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease.

  Biochemical pharmacology 20020115

• Toward the rational design of protein kinase casein kinase-2 inhibitors.

  Pharmacology & therapeutics 20020101

• Evaluation of the clastogenic, DNA intercalative, and topoisomerase II-interactive properties of bioflavonoids in Chinese hamster V79 cells.

  Environmental and molecular mutagenesis 20020101

• Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation.

  International journal of oncology 20010601

• Structure-activity study on the quinone/quinone methide chemistry of flavonoids.

  Chemical research in toxicology 20010401

• Hydroxylations and methylations of quercetin, fisetin, and catechin by Streptomyces griseus.

  Journal of natural products 20010401

• Structure activity relationships for the chemical behaviour and toxicity of electrophilic quinones/quinone methides.

  Advances in experimental medicine and biology 20010101

• Steroid hormone activity of flavonoids and related compounds.

  Breast cancer research and treatment 20000701

• Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines.

  Anticancer research 20000101

• Application of the electrotopological state index to QSAR analysis of flavone derivatives as HIV-1 integrase inhibitors.

  Pharmaceutical research 19961201

• Inhibition of HIV activation in latently infected cells by flavonoid compounds.

  AIDS research and human retroviruses 19960101

• Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds.

  Biochemical pharmacology 19940803

• Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.

  Journal of natural products 19940101

• Flavones are inhibitors of HIV-1 proteinase.

  Biochemical and biophysical research communications 19921030

• Antimicrobial constituents of Gomphrena martiana and Gomphrena boliviana.

  Journal of ethnopharmacology 19920401

• Inhibition of reverse transcriptases by flavonoids.

  Antiviral research 19890901