530-78-9 | Flufenamic acid

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$10.00	$7.00
1g	98%	in stock	$26.00	$18.00
10g	≥98%	in stock	$30.00	$21.00
25g	>98.0%(T)(HPLC)	in stock	$53.00	$37.00
50g	≥98%	in stock	$87.00	$61.00
100g	≥98%	in stock	$156.00	$109.00
250g	≥98%	in stock	$310.00	$217.00
500g	>98.0%(T)(HPLC)	in stock	$415.00	$291.00

Description

• Catalog Number: AB74240
• Chemical Name: Flufenamic acid
• CAS Number: 530-78-9
• Molecular Formula: C14H10F3NO2
• Molecular Weight: 281.2299
• MDL Number: MFCD00002422
• SMILES: OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F

Computed Properties

• Complexity: 346
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: 5.2

Literature

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  BMC dermatology 20090101

• cAMP-dependent chloride conductance evokes ammonia-induced blebbing in the microglial cell line, BV-2.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101

• Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis.

  PloS one 20090101

• Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia.

  PloS one 20090101

• Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers.

  Molecular cancer 20090101

• Determination of diclofenac on a dysprosium nanowire- modified carbon paste electrode accomplished in a flow injection system by advanced filtering.

  Sensors (Basel, Switzerland) 20090101

• Drug delivery from gold and titanium surfaces using self-assembled monolayers.

  Biomaterials 20081201

• Dopamides, vanillylamides, ethanolamides, and arachidonic acid amides of anti-inflammatory and analgesic drug substances as TRPV1 ligands.

  ChemMedChem 20081201

• Identification of pore residues engaged in determining divalent cationic permeation in transient receptor potential melastatin subtype channel 2.

  The Journal of biological chemistry 20081010

• Validation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of R-flurbiprofen using a single-isomer amino cyclodextrin derivative.

  Journal of chromatography. A 20080919

• Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels.

  Endocrinology 20080901

• P2X7 receptor-Pannexin1 complex: pharmacology and signaling.

  American journal of physiology. Cell physiology 20080901

• Charge compensation for NADPH oxidase activity in microglia in rat brain slices does not involve a proton current.

  The European journal of neuroscience 20080901

• Determination of flurbiprofen enantiomers in plasma using a single-isomer amino cyclodextrin derivative in nonaqueous capillary electrophoresis.

  Electrophoresis 20080901

• Further characterization of cation channels present in the chicken red blood cell membrane.

  Bioelectrochemistry (Amsterdam, Netherlands) 20080801

• Extrinsic fluorescent dyes as tools for protein characterization.

  Pharmaceutical research 20080701

• Metabotropic receptor-activated calcium increases and store-operated calcium influx in mouse Müller cells.

  Investigative ophthalmology & visual science 20080701

• Flufenamic acid affects multiple currents and causes intracellular Ca2+ release in Aplysia bag cell neurons.

  Journal of neurophysiology 20080701

• Hypertonicity-induced cation channels rescue cells from staurosporine-elicited apoptosis.

  Apoptosis : an international journal on programmed cell death 20080701

• Non-selective cation channel blockers: potential use in nervous system basic research and therapeutics.

  Mini reviews in medicinal chemistry 20080701

• Intracellular Ca2+ store depletion induces the formation of macromolecular complexes involving hTRPC1, hTRPC6, the type II IP3 receptor and SERCA3 in human platelets.

  Biochimica et biophysica acta 20080601

• Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes.

  The Journal of physiology 20080515

• ACh-induced depolarization in inner ear artery is generated by activation of a TRP-like non-selective cation conductance and inactivation of a potassium conductance.

  Hearing research 20080501

• The use of reconstructed human epidermis for skin absorption testing: Results of the validation study.

  Alternatives to laboratory animals : ATLA 20080501

• The physicochemical parameters of marker compounds and vehicles for use in in vitro percutaneous absorption studies.

  Alternatives to laboratory animals : ATLA 20080501

• Kisspeptin depolarizes gonadotropin-releasing hormone neurons through activation of TRPC-like cationic channels.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080423

• Stimulated efflux of amino acids and glutathione from cultured hippocampal slices by omission of extracellular calcium: likely involvement of connexin hemichannels.

  The Journal of biological chemistry 20080418

• Development and validation of a screening procedure for the assessment of inhibition using a recombinant enzyme.

  Talanta 20080415

• ATP release by way of connexin 36 hemichannels mediates ischemic tolerance in vitro.

  Biochemical and biophysical research communications 20080328

• H2O 2-stimulated Ca2+ influx via TRPM2 is not the sole determinant of subsequent cell death.

  Pflugers Archiv : European journal of physiology 20080301

• Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB).

  British journal of pharmacology 20080301

• catena-Poly[[bis-[2-(2,3-dimethyl-anilino)benzoato-κO]cadmium(II)]-di-μ-3-pyridylmethanol-κN:O;κO:N].

  Acta crystallographica. Section E, Structure reports online 20080301

• Eupnea of in situ rats persists following blockers of in vitro pacemaker burster activities.

  Respiratory physiology & neurobiology 20080227

• Conception of myeloperoxidase inhibitors derived from flufenamic acid by computational docking and structure modification.

  Bioorganic & medicinal chemistry 20080215

• Simultaneous determination of aceclofenac and its three metabolites in plasma using liquid chromatography-tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20080213

• In-silico model of skin penetration based on experimentally determined input parameters. Part I: experimental determination of partition and diffusion coefficients.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080201

• Allergic contact dermatitis to etofenamate. Cross-reaction to other nonsteroidal anti-inflammatory drugs.

  Contact dermatitis 20080201

• The protective effect of functional connexin43 channels on a human epithelial cell line exposed to oxidative stress.

  Investigative ophthalmology & visual science 20080201

• Multivariate optimisation and validation of a capillary electrophoresis method for the analysis of resveratrol in a nutraceutical.

  Talanta 20080115

• Constitutively active TRPC3 channels regulate basal ganglia output neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080109

• Angiotensin II-stimulated Ca2+ entry mechanisms in afferent arterioles: role of transient receptor potential canonical channels and reverse Na+/Ca2+ exchange.

  American journal of physiology. Renal physiology 20080101

• What role do pacemakers play in the generation of respiratory rhythm?

  Advances in experimental medicine and biology 20080101

• Contribution of pacemaker neurons to respiratory rhythms generation in vitro.

  Advances in experimental medicine and biology 20080101

• Influence of human skin specimens consisting of different skin layers on the result of in vitro permeation experiments.

  Skin pharmacology and physiology 20080101

• Chloride influx provokes lamellipodium formation in microglial cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101

• A Role for the PPARgamma in Cancer Therapy.

  PPAR research 20080101

• Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies.

  PPAR research 20080101

• Peroxisome proliferator-activated receptors in the modulation of the immune/inflammatory response in atherosclerosis.

  PPAR research 20080101

• Potential developmental neurotoxicity of pesticides used in Europe.

  Environmental health : a global access science source 20080101

• Development of selective blockers for Ca²(+)-activated Cl channel using Xenopus laevis oocytes with an improved drug screening strategy.

  Molecular brain 20080101

• Gap junction mediated intercellular metabolite transfer in the cochlea is compromised in connexin30 null mice.

  PloS one 20080101

• Blockade of chloride channels suppresses engulfment of microspheres in the microglial cell line, BV-2.

  Brain research 20071212

• Light-evoked calcium responses of isolated melanopsin-expressing retinal ganglion cells.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20071205

• Low-E probe for (19)F-(1)H NMR of dilute biological solids.

  Journal of magnetic resonance (San Diego, Calif. : 1997) 20071201

• Perspectives on transdermal ultrasound mediated drug delivery.

  International journal of nanomedicine 20071201

• Anti-inflammatory and immune therapy for Alzheimer's disease: current status and future directions.

  Current neuropharmacology 20071201

• Thermodynamic properties of flufenamic and niflumic acids--specific and non-specific interactions in solution and in crystal lattices, mechanism of solvation, partitioning and distribution.

  Journal of pharmaceutical and biomedical analysis 20071130

• Estimation of the transition temperature for an enantiotropic polymorphic system from the transformation kinetics monitored using Raman spectroscopy.

  Journal of pharmaceutical and biomedical analysis 20071130

• New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose.

  Neurochemical research 20071101

• Characteristics of biphasic slow depolarizing and slow hyperpolarizing potential in frog taste cell induced by parasympathetic efferent stimulation.

  Chemical senses 20071101

• Store-operated calcium entry mediates intracellular alkalinization, ERK1/2, and Akt/PKB phosphorylation in bovine neutrophils.

  Journal of leukocyte biology 20071101

• Calcium-dependent fast depolarizing afterpotentials in vasopressin neurons in the rat supraoptic nucleus.

  Journal of neurophysiology 20071101

• Inhibition of the Na+/dicarboxylate cotransporter by anthranilic acid derivatives.

  Molecular pharmacology 20071101

• Extracellular interconversion of nucleotides reveals an ecto-adenylate kinase activity in the rat hippocampus.

  Neurochemical research 20071101

• Effects of ginseng total saponins on pacemaker currents of interstitial cells of Cajal from the small intestine of mice.

  Biological & pharmaceutical bulletin 20071101

• Models for binding cooperativities of inhibitors with transthyretin.

  Archives of biochemistry and biophysics 20071001

• Small-conductance Cl- channels contribute to volume regulation and phagocytosis in microglia.

  The European journal of neuroscience 20071001

• Topical etofenamate to facilitate venipuncture.

  Pediatric emergency care 20071001

• Inhibition of the myeloperoxidase chlorinating activity by non-steroidal anti-inflammatory drugs: flufenamic acid and its 5-chloro-derivative directly interact with a recombinant human myeloperoxidase to inhibit the synthesis of hypochlorous acid.

  European journal of pharmacology 20070910

• Characterization of an oligomeric carbonyl reductase of dog liver: its identity with peroxisomal tetrameric carbonyl reductase.

  Biological & pharmaceutical bulletin 20070901

• Are pacemaker properties required for respiratory rhythm generation in adult turtle brain stems in vitro?

  American journal of physiology. Regulatory, integrative and comparative physiology 20070801

• A novel inhibitor of hypertonicity-induced cation channels in HeLa cells.

  The journal of physiological sciences : JPS 20070801

• Phosphatidylinositol 4,5-bisphosphate regulates inspiratory burst activity in the neonatal mouse preBötzinger complex.

  The Journal of physiology 20070801

• Sex pheromone production in the silkworm, Bombyx mori, is mediated by store-operated Ca2+ channels.

  Bioscience, biotechnology, and biochemistry 20070801

• Medullary pacemaker neurons are essential for both eupnea and gasping in mammals vs. medullary pacemaker neurons are essential for gasping, but not eupnea, in mammals.

  Journal of applied physiology (Bethesda, Md. : 1985) 20070801

• Medullary pacemaker neurons are essential for both eupnea and gasping in mammals vs. medullary pacemaker neurons are essential for gasping, but not eupnea, in mammals.

  Journal of applied physiology (Bethesda, Md. : 1985) 20070801

• Clinical studies with oral lipid based formulations of poorly soluble compounds.

  Therapeutics and clinical risk management 20070801

• Flufenamic acid bi-directionally modulates the transient outward K(+) current in rat cerebellar granule cells.

  The Journal of pharmacology and experimental therapeutics 20070701

• Inspiratory bursts in the preBötzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice.

  The Journal of physiology 20070701

• A calcium-activated nonselective cation conductance underlies the plateau potential in rat substantia nigra GABAergic neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070613

• Basolateral Cl channels in primary airway epithelial cultures.

  American journal of physiology. Lung cellular and molecular physiology 20070601

• Eicosanoid biosynthesis inhibitors increase the susceptibility of Lymantria dispar to nucleopolyhedrovirus LdMNPV.

  Journal of invertebrate pathology 20070601

• Non-steroidal anti-inflammatory drugs increase insulin release from beta cells by inhibiting ATP-sensitive potassium channels.

  British journal of pharmacology 20070601

• Persistent sodium current in preBotzinger neurons is not necessary for respiratory rhythm generation in the neonatal mouse?

  The Journal of physiology 20070601

• Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to cholecystokinin are mediated by a transient receptor potential-like current.

  Molecular and cellular neurosciences 20070601

• Determination of degradation pathways and kinetics of acyl glucuronides by NMR spectroscopy.

  Chemical research in toxicology 20070601

• Glucuronidation of fenamates: kinetic studies using human kidney cortical microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7.

  Biochemical pharmacology 20070515

• First pharmacophore-based identification of androgen receptor down-regulating agents: discovery of potent anti-prostate cancer agents.

  Bioorganic & medicinal chemistry 20070515

• Analysis of slow depolarizing potential in frog taste cell induced by parasympathetic efferent stimulation under hypoxia.

  Chemical senses 20070501

• Endothelin-1 activates a Ca2+-permeable cation channel with TRPC3 and TRPC7 properties in rabbit coronary artery myocytes.

  The Journal of physiology 20070501

• Functionalized magnetic nanoparticles for small-molecule isolation, identification, and quantification.

  Analytical chemistry 20070501

• Effect of selected fluorinated drugs in a 'ringing' gel on rheological behaviour and skin permeation.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070401

• Mechanism of interaction of niflumic acid with heterologously expressed kidney CLC-K chloride channels.

  The Journal of membrane biology 20070401

• Effects of riluzole and flufenamic acid on eupnea and gasping of neonatal mice in vivo.

  Neuroscience letters 20070330

• Gap junction hemichannel-mediated release of glutathione from cultured rat astrocytes.

  Neuroscience letters 20070319

• Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase.

  The Journal of biological chemistry 20070316

• Activity-dependent initiation of a prolonged depolarization in aplysia bag cell neurons: role for a cation channel.

  Journal of neurophysiology 20070301

• Multicommutated flow-through optosensors implemented with photochemically induced fluorescence: determination of flufenamic acid.

  Analytical biochemistry 20070215

• TRPM4, a Ca2+-activated nonselective cation channel in mouse sino-atrial node cells.

  Cardiovascular research 20070201

• Depolarization evoked by acetylcholine in mesenteric arteries of hypertensive rats attenuates endothelium-dependent hyperpolarizing factor.

  Journal of hypertension 20070201

• Antagonist effect of flufenamic acid on TRPM2 cation channels activated by hydrogen peroxide.

  Cell biochemistry and function 20070101

• Overlapping pharmacology of Ca2+-activated Cl- and K+ channels.

  Trends in pharmacological sciences 20070101

• Inhibition of eryptosis and intraerythrocytic growth of Plasmodium falciparum by flufenamic acid.

  Naunyn-Schmiedeberg's archives of pharmacology 20070101

• Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media.

  Archiv der Pharmazie 20070101

• TRPM2.

  Handbook of experimental pharmacology 20070101

• N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker.

  Cardiovascular drug reviews 20070101

• Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain.

  PloS one 20070101

• Screening of gap junction antagonists on dye coupling in the rabbit retina.

  Visual neuroscience 20070101

• [Etofenamate and the analgesic effect in the management of acute pain from spine in the emergency room].

  Acta ortopedica mexicana 20070101

• [Ventricular extrasystole as manifestation of viral myocarditis and myopericarditis in young patients].

  Terapevticheskii arkhiv 20070101

• The pK(a) Distribution of Drugs: Application to Drug Discovery.

  Perspectives in medicinal chemistry 20070101

• Polymeric nanoparticles, nanospheres and nanocapsules, for cutaneous applications.

  Drug target insights 20070101

• Angiotensin II activates two cation conductances with distinct TRPC1 and TRPC6 channel properties in rabbit mesenteric artery myocytes.

  The Journal of physiology 20061201

• Diflunisal stabilizes familial amyloid polyneuropathy-associated transthyretin variant tetramers in serum against dissociation required for amyloidogenesis.

  Neuroscience research 20061201

• Muscarinic control of graded persistent activity in lateral amygdala neurons.

  The European journal of neuroscience 20061201

• Effects of flufenamic acid on fictive locomotion, plateau potentials, calcium channels and NMDA receptors in the lamprey spinal cord.

  Neuropharmacology 20061101

• Non-steroidal anti-inflammatory drugs for heavy bleeding or pain associated with intrauterine-device use.

  The Cochrane database of systematic reviews 20061018

• Additive-induced metastable single crystal of mefenamic acid.

  Pharmaceutical research 20061001

• Functional expression of the TRPM4 cationic current in ventricular cardiomyocytes from spontaneously hypertensive rats.

  Hypertension (Dallas, Tex. : 1979) 20061001

• Comparison of bovine udder skin with human and porcine skin in percutaneous permeation experiments.

  Alternatives to laboratory animals : ATLA 20061001

• Purine release from spinal cord microglia after elevation of calcium by glutamate.

  Molecular pharmacology 20060901

• VEGF activates receptor-operated cation channels in human microvascular endothelial cells.

  Arteriosclerosis, thrombosis, and vascular biology 20060801

• A TRPC-like non-selective cation current activated by alpha 1-adrenoceptors in rat mesenteric artery smooth muscle cells.

  Cell calcium 20060701

• Swelling-activated Cl- channels support Cl- secretion by bovine ciliary epithelium.

  Investigative ophthalmology & visual science 20060601

• TEWL measurements as a routine method for evaluating the integrity of epidermis sheets in static Franz type diffusion cells in vitro. Limitations shown by transport data testing.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• The light-activated signaling pathway in SCN-projecting rat retinal ganglion cells.

  The European journal of neuroscience 20060501

• Norepinephrine differentially modulates different types of respiratory pacemaker and nonpacemaker neurons.

  Journal of neurophysiology 20060401

• Actions of glutamate and ivermectin on the pharyngeal muscle of Ascaridia galli: a comparative study with Caenorhabditis elegans.

  International journal for parasitology 20060401

• Calcium antagonist isradipine-induced calcium influx through nonselective cation channels in human gingival fibroblasts.

  European journal of medical research 20060327

• Gasping activity in vitro: a rhythm dependent on 5-HT2A receptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060308

• Bistable behavior originating in the axon of a crustacean motor neuron.

  Journal of neurophysiology 20060301

• Neuronal chloride accumulation in olfactory epithelium of mice lacking NKCC1.

  Journal of neurophysiology 20060301

• Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily.

  The Journal of pharmacology and experimental therapeutics 20060301

• TRPC3 properties of a native constitutively active Ca2+-permeable cation channel in rabbit ear artery myocytes.

  The Journal of physiology 20060301

• Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.

  Biological & pharmaceutical bulletin 20060301

• Second-order calibration of excitation-emission matrix fluorescence spectra for the determination of N-phenylanthranilic acid derivatives.

  Applied spectroscopy 20060301

• A 'sample-and-hold' pulse-counting integrator as a mechanism for graded memory underlying sensorimotor adaptation.

  Neuron 20060216

• P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060201

• Endogenous hemichannels play a role in the release of ATP from Xenopus oocytes.

  Journal of cellular physiology 20060101

• Activation and inhibition of kidney CLC-K chloride channels by fenamates.

  Molecular pharmacology 20060101

• Diversity of Cl(-) channels.

  Cellular and molecular life sciences : CMLS 20060101

• Influence of nanoencapsulation on human skin transport of flufenamic acid.

  Skin pharmacology and physiology 20060101

• Anti-inflammatory and immunosuppressive drugs and reproduction.

  Arthritis research & therapy 20060101

• Calcium-sensing receptor stimulation induces nonselective cation channel activation in breast cancer cells.

  The Journal of membrane biology 20060101

• Inhibition of hypertonicity-induced cation channels sensitizes HeLa cells to shrinkage-induced apoptosis.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

• New potential anticancer agents based on the anthranilic acid scaffold: synthesis and evaluation of biological activity.

  Journal of medicinal chemistry 20051229

• Fenamates and diltiazem modulate lipid-sensitive mechano-gated 2P domain K(+) channels.

  Pflugers Archiv : European journal of physiology 20051201

• Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer agents.

  Bioorganic & medicinal chemistry letters 20051201

• Effects of inhibitors of nonselective cation channels on the acetylcholine-induced depolarization of circular smooth muscle from the guinea-pig stomach antrum.

  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20051201

• Thiol-containing molecules interact with the myeloperoxidase/H2O2/chloride system to inhibit LDL oxidation.

  Biochemical and biophysical research communications 20051111

• Partial mitochondrial inhibition causes striatal dopamine release suppression and medium spiny neuron depolarization via H2O2 elevation, not ATP depletion.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20051026

• Fluid secretion and the Na+-K+-2Cl- cotransporter in mouse exorbital lacrimal gland.

  American journal of physiology. Cell physiology 20051001

• The role of TRPM channels in cell death.

  Pflugers Archiv : European journal of physiology 20051001

• Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses.

  Current drug targets. CNS and neurological disorders 20051001

• Inhibition study of rabbit liver cytosolic reductases involved in daunorubicin toxication.

  Journal of enzyme inhibition and medicinal chemistry 20051001

• NMDA enhances a depolarization-activated inward current in subthalamic neurons.

  Neuropharmacology 20050901

• Understanding solid-state reactions of organic crystals with density functional theory-based concepts.

  The journal of physical chemistry. A 20050818

• Characterization of a proton-activated, outwardly rectifying anion channel.

  The Journal of physiology 20050815

• The effects of flufenamic acid on spontaneous activity of smooth muscle tissue isolated from the guinea-pig stomach antrum.

  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20050801

• Gain modulation by serotonin in pyramidal neurones of the rat prefrontal cortex.

  The Journal of physiology 20050715

• A quantitative model to evaluate solubility relationship of polymorphs from their thermal properties.

  Pharmaceutical research 20050701

• Mechanisms of Na+ and Ca2+ influx into respiratory neurons during hypoxia.

  Neuropharmacology 20050601

• Gap junction channels reconstituted in two closely apposed lipid bilayers.

  Archives of biochemistry and biophysics 20050401

• UDP-glucuronosyltransferases and clinical drug-drug interactions.

  Pharmacology & therapeutics 20050401

• ATP release through connexin hemichannels in corneal endothelial cells.

  Investigative ophthalmology & visual science 20050401

• Blockade of chloride conductance antagonizes PMA-induced ramification in the murine microglial cell line, BV-2.

  Brain research 20050328

• Comparison of four different in vitro systems to study the reservoir capacity of the stratum corneum.

  Journal of controlled release : official journal of the Controlled Release Society 20050302

• Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice.

  Cell calcium 20050301

• Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes.

  Journal of neurochemistry 20050301

• Dicumarol is a potent reversible inhibitor of gap junctional intercellular communication.

  Archives of biochemistry and biophysics 20050215

• Cyclic nucleotide signaling mediates an odorant-suppressible chloride conductance in lobster olfactory receptor neurons.

  Chemical senses 20050201

• Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050112

• Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: potential antineoplastic agents that work independently of cyclooxygenase isozymes.

  Molecular pharmacology 20050101

• Novel properties of a mouse gamma-aminobutyric acid transporter (GAT4).

  The Journal of membrane biology 20050101

• Application of stable isotope labeled glutathione and rapid scanning mass spectrometers in detecting and characterizing reactive metabolites.

  Rapid communications in mass spectrometry : RCM 20050101

• Compounds exhibiting selective efficacy for different beta subunits of human recombinant gamma-aminobutyric acid A receptors.

  The Journal of pharmacology and experimental therapeutics 20041101

• Analysis of slow hyperpolarizing potentials in frog taste cells induced by glossopharyngeal nerve stimulation.

  Chemical senses 20041001

• Voltage- and Ca2+-dependent burst generation in neuroendocrine Dahlgren cells in the teleost Platichthys flesus.

  Journal of neuroendocrinology 20041001

• Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole.

  Naunyn-Schmiedeberg's archives of pharmacology 20041001

• Flufenamic acid is a pH-dependent antagonist of TRPM2 channels.

  Neuropharmacology 20040901

• Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity.

  Bioorganic & medicinal chemistry 20040801

• Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy.

  The Journal of general physiology 20040801

• Activation of a calcium-activated cation current during epileptiform discharges and its possible role in sustaining seizure-like events in neocortical slices.

  Journal of neurophysiology 20040801

• Analysis of ketorolac and its related impurities by capillary electrochromatography.

  Journal of chromatography. A 20040730

• Synthesis and pharmacological evaluation of amide conjugates of NSAIDs with L-cysteine ethyl ester, combining potent antiinflammatory and antioxidant properties with significantly reduced gastrointestinal toxicity.

  Bioorganic & medicinal chemistry letters 20040716

• Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative.

  The Biochemical journal 20040715

• Substance P induces inward current and regulates pacemaker currents through tachykinin NK1 receptor in cultured interstitial cells of Cajal of murine small intestine.

  European journal of pharmacology 20040708

• Differential contribution of pacemaker properties to the generation of respiratory rhythms during normoxia and hypoxia.

  Neuron 20040708

• Functional characterization of a Ca(2+)-activated non-selective cation channel in human atrial cardiomyocytes.

  The Journal of physiology 20040701

• Effects of various vehicles on the penetration of flufenamic acid into human skin.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20040701

• Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver.

  Biochemical pharmacology 20040601

• Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants.

  Laboratory investigation; a journal of technical methods and pathology 20040501

• Micellar electrokinetic chromatography for the simultaneous determination of ketorolac tromethamine and its impurities. Multivariate optimization and validation.

  Journal of chromatography. A 20040402

• Enzymology of a carbonyl reduction clearance pathway for the HIV integrase inhibitor, S-1360: role of human liver cytosolic aldo-keto reductases.

  Chemico-biological interactions 20040315

• Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.

  The Journal of biological chemistry 20040312

• Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo.

  American journal of physiology. Heart and circulatory physiology 20040301

• Transient receptor potential-like channels mediate metabotropic glutamate receptor EPSCs in rat dopamine neurones.

  The Journal of physiology 20040301

• Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin.

  Cancer research 20040301

• Calcium-dependent subthreshold oscillations determine bursting activity induced by N-methyl-D-aspartate in rat subthalamic neurons in vitro.

  The European journal of neuroscience 20040301

• Mechanism of apoptosis induced by diazoxide, a K+ channel opener, in HepG2 human hepatoma cells.

  Archives of pharmacal research 20040301

• Detergents profoundly affect inhibitor potencies against both cyclo-oxygenase isoforms.

  The Biochemical journal 20040201

• Epigallocatechin-3-gallate increases intracellular [Ca2+] in U87 cells mainly by influx of extracellular Ca2+ and partly by release of intracellular stores.

  Naunyn-Schmiedeberg's archives of pharmacology 20040201

• Amyloidosis: a clinico-pathophysiological synopsis.

  Seminars in cell & developmental biology 20040201

• Astrocytic connectivity in the hippocampus.

  Neuron glia biology 20040201

• Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis.

  BMC musculoskeletal disorders 20040101

• Interactions of benzylpenicillin and non-steroidal anti-inflammatory drugs with the sodium-dependent dicarboxylate transporter NaDC-3.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20040101

• [Comparative clinical multicenter study to evaluate analgesic effectiveness of intramuscular etofenamate and diclofenac in patients with post-surgical pain].

  Cirugia y cirujanos 20040101

• Diclofenac inhibition of sodium currents in rat dorsal root ganglion neurons.

  Brain research 20031128

• Fundamental role of ClC-3 in volume-sensitive Cl- channel function and cell volume regulation in AGS cells.

  American journal of physiology. Gastrointestinal and liver physiology 20031101

• Pharmacological sensitivity of ATP release triggered by photoliberation of inositol-1,4,5-trisphosphate and zero extracellular calcium in brain endothelial cells.

  Journal of cellular physiology 20031101

• In situ monitoring of wet granulation using online X-ray powder diffraction.

  Pharmaceutical research 20031101

• Involvement of transient receptor potential-like channels in responses to mGluR-I activation in midbrain dopamine neurons.

  The European journal of neuroscience 20031001

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  The British journal of ophthalmology 20021201

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  The Journal of physiology 20021201

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  Bioorganic & medicinal chemistry 20020301

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  The Journal of investigative dermatology 20020301

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  Journal of vascular and interventional radiology : JVIR 20020101

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  Toxicologic pathology 20020101

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• Combined contact and photocontact allergic dermatitis to etofenamate in flogoprofen gel.

  American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 20011201

• Comparative study of etofenamate and fentanyl for outpatient extracorporeal shockwave lithotripsy.

  Scandinavian journal of urology and nephrology 20011201

• Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes.

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  The Biochemical journal 20010915

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  Current eye research 20010601

• WY-14,643 and other agonists of the peroxisome proliferator-activated receptor reveal a new mode of action for salicylic acid in soybean disease resistance.

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  Hepatology (Baltimore, Md.) 20010101

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  BMC biochemistry 20010101

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  ALTEX 20010101

• Screening procedure for detection of non-steroidal anti-inflammatory drugs and their metabolites in urine as part of a systematic toxicological analysis procedure for acidic drugs and poisons by gas chromatography-mass spectrometry after extractive methylation.

  Journal of analytical toxicology 20010101

• Etofenamate levels in human serum and synovial fluid following iontophoresis.

  Arzneimittel-Forschung 20010101

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  Microsurgery 20010101

• Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways.

  The Journal of biological chemistry 20000908

• A nonsteroidal anti-inflammatory drug, flufenamic acid, inhibits the expression of the androgen receptor in LNCaP cells.

  Endocrinology 19991101

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  Nature 19990923

• Enhancement of low density lipoprotein catabolism by non-steroidal anti-inflammatory drugs in cultured HepG2 cells.

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• Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs.

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• Evidence for a role for the cyclic adenosine 3',5'-monophosphate/protein kinase-A pathway in regulation of the gonadotropin subunit messenger ribonucleic acids.

  Endocrinology 19931101

• Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates.

  The Journal of general physiology 19930701

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