54-42-2 | Idoxuridine

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$13.00	$9.00
5g	98%	in stock	$30.00	$21.00
10g	98%	in stock	$40.00	$28.00

Description

• Catalog Number: AB53099
• Chemical Name: Idoxuridine
• CAS Number: 54-42-2
• Molecular Formula: C9H11IN2O5
• Molecular Weight: 354.0985
• MDL Number: MFCD00134656
• SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1cc(I)c(=O)[nH]c1=O

Computed Properties

• Complexity: 386
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 3
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 2
• XLogP3: -1

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  Seminars in radiation oncology 20011001

• Cytotoxicity of 125I-oestrogen decay in non-oestrogen receptor-expressing human breast cancer cells, MDA-231 and oestrogen receptor-expressing MCF-7 cells.

  International journal of radiation biology 20010901

• Monte Carlo simulations and measurement of DNA damage from x-ray-triggered auger cascades in iododeoxyuridine (IUdR).

  Radiation and environmental biophysics 20010901

• Antiviral drugs: current state of the art.

  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20010801

• Recruitment of mononuclear leucocytes to osteoarthritic human synovial xenografts in the ears of SCID mice.

  Immunology and cell biology 20010801

• Increased glomerular Vwf after kidney irradiation is not due to increased biosynthesis or endothelial cell proliferation.

  Radiation research 20010701

• Laser-induced photo-cross-linking of cisplatin-modified DNA to HMG-domain proteins.

  Biochemistry 20010626

• A flow cytometry technique for measuring chromosome-mediated gene transfer.

  Cytometry 20010601

• Contact dermatitis from topical antiviral drugs.

  Contact dermatitis 20010501

• Chemical modification of 5-[125I]iodo-2'-deoxyuridine toxicity in mammalian cells in vitro.

  International journal of radiation biology 20010501

• [[(18)F]N-(4'-fluorobenzyl)-4-(3-bromophenyl) acetamide for imaging the sigma receptor status of tumors: comparison with [(18)F]FDG, and [(125)I]IUDR.

  Nuclear medicine and biology 20010501

• Phase I trial of sequential administration of raltitrexed (Tomudex) and 5-iodo-2'-deoxyuridine (IdUrd).

  Annals of oncology : official journal of the European Society for Medical Oncology 20010501

• Targets for radiation-induced cell death: when DNA damage doesn't kill.

  Radiation research 20010401

• Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections.

  Clinical microbiology reviews 20010401

• Evidence that postoperative pain is a mediator of the tumor-promoting effects of surgery in rats.

  Pain 20010201

• Is there a future for cell kinetic measurements using IdUrd or BdUrd?

  International journal of radiation oncology, biology, physics 20010201

• Relative biological effectiveness of accumulated 125IdU and 125I-estrogen decays in estrogen receptor-expressing MCF-7 human breast cancer cells.

  Radiation research 20010201

• Preclinical evaluation of locoregional delivery of radiolabeled iododeoxyuridine and thymidylate synthase inhibitor in a hepatoma model.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20010201

• Laser cytometry of human tissues and tumors: proliferation and therapeutic applications.

  Methods in cell biology 20010101

• Antizona and antisperm antibodies in women with endometriosis and/or infertility.

  Fertility and sterility 20010101

• In vitro effects of antiviral agents on human keratocytes.

  Cornea 20010101

• Interventions for herpes simplex virus epithelial keratitis.

  The Cochrane database of systematic reviews 20010101

• Efficient in-vitro transfer of a 60-Mb mammalian artificial chromosome into murine and hamster cells using cationic lipids and dendrimers.

  Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 20010101

• Pert analysis of endogenous retroviruses induced from K-BALB mouse cells treated with 5-iododeoxyuridine: a potential strategy for detection of inducible retroviruses from vaccine cell substrates.

  Developments in biologicals 20010101

• Hypoxia and perfusion measurements in human tumors--initial experience with pimonidazole and IUdR.

  Acta oncologica (Stockholm, Sweden) 20010101

• Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes.

  The Biochemical journal 20001015

• Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase.

  The Journal of biological chemistry 19990618

• Comparison of spontaneous and idoxuridine-induced micronuclei by chromosome painting.

  Mutation research 19990406

• Efficacy of select antivirals against Cryptosporidium parvum in vitro.

  FEMS microbiology letters 19981101

• Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine).

  Journal of intravenous nursing : the official publication of the Intravenous Nurses Society 19980101

• Structure-activity relationship of the affinity of 5-substituted uracil nucleoside analogues for varicella-zoster virus thymidine kinase and their activity against varicella-zoster virus.

  Antiviral research 19970801

• Functional characterization of a recombinant sodium-dependent nucleoside transporter with selectivity for pyrimidine nucleosides (cNT1rat) by transient expression in cultured mammalian cells.

  The Biochemical journal 19960715

• Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6.

  Antiviral research 19951201

• Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: molecular basis for the antiviral activity of unnatural L-beta-nucleosides.

  Biochimie 19950101

• Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.

  Journal of medicinal chemistry 19940916

• Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.

  Journal of medicinal chemistry 19930709

• Metabolism and mode of selective inhibition of human immunodeficiency virus replication by 3'-azido-2',3'-dideoxy-5-iodouridine and 3'-azido-2',3'-dideoxy-5-bromouridine.

  Biochemical pharmacology 19930107

• In vitro antiviral activity of polyoxotungstate (PM-19) and other polyoxometalates against herpes simplex virus.

  Antiviral research 19911201

• The effect of radiosensitizers on radio-immunotherapy, using 131I-labelled anti-CEA antibodies in a human colonic xenograft model.

  International journal of cancer 19910220

• In vitro screening for antiretroviral agents against simian immunodeficiency virus (SIV).

  Antiviral research 19900801

• Phorbol ester-mediated induction of HIV-1 from a chronically infected promonocyte clone: blockade by protein kinase inhibitors and relationship to tat-directed trans-activation.

  Biochemical and biophysical research communications 19900115

• Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.

  Journal of medicinal chemistry 19890801

• Synthesis and antiviral activity of phosphonoacetic and phosphonoformic acid esters of 5-bromo-2'-deoxyuridine and related pyrimidine nucleosides and acyclonucleosides.

  Journal of medicinal chemistry 19890201

• Inhibition of herpes simplex virus infection by tannins and related compounds.

  Antiviral research 19890101

• Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.

  Journal of medicinal chemistry 19880901

• Efficacies of antiherpesvirus nucleosides against two strains of herpes simplex virus type 1 in Vero and human embryo lung fibroblast cells.

  Antimicrobial agents and chemotherapy 19880701

• 2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.

  Journal of medicinal chemistry 19870701

• In vitro and in vivo antiviral activity of 2'-fluorinated arabinosides of 5-(2-haloalkyl)uracil.

  Antiviral research 19870601

• Inhibiting effect of (RS)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine on varicella-zoster virus replication in cell culture.

  Antimicrobial agents and chemotherapy 19870101

• Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.

  Journal of medicinal chemistry 19860701

• Comparison of susceptibilities of varicella-zoster virus and herpes simplex viruses to nucleoside analogs.

  Antimicrobial agents and chemotherapy 19860301

• Interaction of monoclonal antibodies directed against bromodeoxyuridine with pyrimidine bases, nucleosides, and DNA.

  Journal of immunology (Baltimore, Md. : 1950) 19860301

• 5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.

  Journal of medicinal chemistry 19851101

• Selective in vitro and in vivo activities of 5-(2-haloalkyl)pyrimidine nucleoside analogs, particularly 5-(2-chloroethyl)-2'-deoxyuridine, against herpes simplex virus.

  Antimicrobial agents and chemotherapy 19850801

• Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.

  Journal of medicinal chemistry 19850501

• Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines.

  Journal of medicinal chemistry 19841101

• Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine 'acyclic' nucleoside analogues.

  Journal of medicinal chemistry 19841101

• Pyrazolo[4,3-d]pyrimidine nucleosides. Synthesis and antiviral activity of 1-beta-D-ribofuranosyl-3-methyl-6-substituted-7H-pyrazolo[4,3-d]pyr imi din-7-ones.

  Journal of medicinal chemistry 19840801

• In vitro and in vivo antiviral activity of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) and related compounds.

  Antiviral research 19840601

• Strains of varicella-zoster virus resistant to 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil.

  Antimicrobial agents and chemotherapy 19840601

• Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1.

  Journal of medicinal chemistry 19840301

• Antiherpes activity of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil and some other 5-substituted uracil arabinosyl nucleosides in two different cell lines.

  Antiviral research 19830901

• Activity of 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)thymine against herpes simplex virus in cell cultures and rabbit eyes.

  Antimicrobial agents and chemotherapy 19830601

• Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.

  Journal of medicinal chemistry 19830501

• Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].

  Journal of medicinal chemistry 19830401

• Carbocyclic analogues of 5-substituted uracil nucleosides: synthesis and antiviral activity.

  Journal of medicinal chemistry 19830201

• Synthesis of some 5'-amino-2',5'-dideoxy-5-iodouridine derivatives and their antiviral properties against herpes simplex virus.

  Antiviral research 19821201

• Synthesis and antiviral properties of some 2'-deoxy-5-(fluoroalkenyl)uridines.

  Journal of medicinal chemistry 19821101

• A new nucleoside analog, 9-[[2-hydroxy-1-(hydroxymethyl)ethoxyl]methyl]guanine, highly active in vitro against herpes simplex virus types 1 and 2.

  Antimicrobial agents and chemotherapy 19820701

• Efficiency and selectivity of (E)-5-(2-bromovinyl)-2'-deoxyuridine and some other 5-substituted 2'-deoxypyrimidine nucleosides as anti-herpes agents.

  Antiviral research 19820501

• Inhibitory effects of antiherpesviral thymidine analogs against varicella-zoster virus.

  Antimicrobial agents and chemotherapy 19820201

• In vitro susceptibility of varicella-zoster virus to E-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.

  Antimicrobial agents and chemotherapy 19820101

• Antiherpesviral and anticellular effects of 1-beta-D-arabinofuranosyl-E-5-(2-halogenovinyl) uracils.

  Antimicrobial agents and chemotherapy 19810701

• Synthesis and antiherpetic activity of some 4-[(aryloxy)alkyl]pyrazoles.

  Journal of medicinal chemistry 19810601

• Synthesis and antiviral activity of 5-[(cyanomethylene)oxy]-2'-deoxyuridine.

  Journal of medicinal chemistry 19810401

• Antiviral, antitumor, and thymidylate synthetase inhibition studies of 5-substituted styryl derivatives of 2'-deoxyuridine and their 5'-phosphates.

  Biochemical pharmacology 19810301

• Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with adenine arabinoside, 5-ethyldeoxyuridine, 5-iododeoxyuridine, and phosphonoacetic acid against herpes simplex virus types 1 and 2.

  Antimicrobial agents and chemotherapy 19800401

• Synthesis of 5-[(methylthio)methyl]-2'-deoxyuridine, the corresponding sulfoxide and sulfone, and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition.

  Journal of medicinal chemistry 19800301

• In vitro and in vivo resistance of herpes simplex virus to 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine).

  Antimicrobial agents and chemotherapy 19800201

• (E)-5-(2-bromovinyl)-2'-Deoxyuridine in the treatment of experimental herpes simplex keratitis.

  Antimicrobial agents and chemotherapy 19800101

• Antiviral activity of 5-methylthiomethyl-2'-deoxyuridine and other 5-substituted 2'-deoxyuridines.

  Biochemical pharmacology 19791115

• Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice.

  Antimicrobial agents and chemotherapy 19791101

• Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.

  Journal of medicinal chemistry 19791001

• In vitro antiherpesviral activity of 5-alkyl derivatives of 1-beta-D-arabinofuranosyluracil.

  Antimicrobial agents and chemotherapy 19790801

• Effect of 5-iodo-5'-amino-2',5'-dideoxyuridine on varicella-zoster virus in vitro.

  Antimicrobial agents and chemotherapy 19790701

• (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.

  Proceedings of the National Academy of Sciences of the United States of America 19790601

• Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides.

  Journal of medicinal chemistry 19790101

• Effects of nucleoside analogs on Epstein-Barr virus-induced transformation of human umbilical cord leukocytes and Epstein-Barr virus expression in transformed cells.

  Antimicrobial agents and chemotherapy 19790101

• Effect of 9-(2-hydroxyethoxymethyl)guanine on herpesvirus-induced keratitis and iritis in rabbits.

  Antimicrobial agents and chemotherapy 19781201

• Trisodium phosphonoformate, a new antiviral compound.

  Science (New York, N.Y.) 19780901

• 9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group.

  Nature 19780413

• 5-Propyl-2'-deoxyuridine: a specific anti-herpes agent.

  Antimicrobial agents and chemotherapy 19780301

• 5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine.

  Journal of medicinal chemistry 19780201

• Improved synthesis and in vitro antiviral activities of 5-cyanouridine and 5-cyano-2'-deoxyuridine.

  Journal of medicinal chemistry 19770701

• Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.

  Journal of medicinal chemistry 19770601

• Antiviral activity of some beta-diketones. 2. Aryloxy alkyl diketones. In vitro activity against both RNA and DNA viruses.

  Journal of medicinal chemistry 19770601

• Antiviral activities of acyl derivatives of 2,2'-anhydro-1-beta-D-arabinofuranosylcytosine and 1-beta-D-arabinofuranosylcytosine in cell culture.

  Antimicrobial agents and chemotherapy 19770201

• Effect of cytosine, arabinoside, iododeoxyuridine, ethyldeoxyuridine, thiocyanatodeoxyuridine, and ribavirin on tail lesion formation in mice infected with vaccinia virus.

  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19760301

• Antiviral and antimetabolic activities of formycin and its N1-, N2-, 2'-O- and 3'-O-methylated derivatives.

  Biochemical pharmacology 19751001

• Bioassay of alkyl halides and nucleotide base analogs by pulmonary tumor response in strain A mice.

  Cancer research 19750601

• Selective inhibition of herpes simplex virus by 5-amino-2,5-dideoxy-5-iodouridine.

  Journal of virology 19750501

• Taratogenic effects of the pyrimidine analogues 5-iododeoxyuridine and cytosine arabinoside in late fetal mice and rats.

  Teratology 19750201

• Assessment of cytosine arabinoside as an antiviral agent in humans.

  Antimicrobial agents and chemotherapy 19741101

• Herpes simplex virus skin infection in hairless mice: treatment with antiviral compounds.

  Antimicrobial agents and chemotherapy 19740301

• Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola.

  Antimicrobial agents and chemotherapy 19730901

• In vitro effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on deoxyribonucleic acid and ribonucleic acid viruses.

  Antimicrobial agents and chemotherapy 19730201

• The antiviral activity of 9-beta-D-arabinofuranosyladenine (ARA-A).

  Chemotherapia 19680101

• Nucleosides. 3. Studies on 5-methylamino-2'-deoxyuridine as a specific antiherpes agent.

  Journal of medicinal chemistry 19660501