5437-25-2 | 9H-Purine-2,6-dithiol

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$30.00	$21.00
1g	95%	in stock	$89.00	$62.00
5g	95%	in stock	$145.00	$101.00

Description

• Catalog Number: AB54232
• Chemical Name: 9H-Purine-2,6-dithiol
• CAS Number: 5437-25-2
• Molecular Formula: C5H4N4S2
• Molecular Weight: 184.2421
• MDL Number: MFCD00871017
• SMILES: S=c1[nH]c(=S)c2c([nH]1)[nH]cn2

Computed Properties

• Complexity: 217
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 3
• XLogP3: 0.5

Literature

• 2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog.

  Toxicology and applied pharmacology 20120901

• Cell signalling by reactive lipid species: new concepts and molecular mechanisms.

  The Biochemical journal 20120315

• Protection against 2-chloroethyl ethyl sulfide (CEES)-induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway.

  Toxicology and applied pharmacology 20110901

• 2,6-Dithiopurine blocks toxicity and mutagenesis in human skin cells exposed to sulfur mustard analogues, 2-chloroethyl ethyl sulfide and 2-chloroethyl methyl sulfide.

  Chemical research in toxicology 20100315

• Acacia Senegal gum exudate offers protection against cyclophosphamide-induced urinary bladder cytotoxicity.

  Oxidative medicine and cellular longevity 20090101

• Mixed effects of 2,6-dithiopurine against cyclophosphamide mediated bladder and lung toxicity in mice.

  Toxicology 19980116

• Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii.

  Biochemical pharmacology 19951109